(57)【特許請求の範囲】
【請求項１】
表１に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型プロスタグランジンＤ合成酵素（ＰＧＤＳ）カルシウム型とグルタチオン（ＧＳＨ）との複合体。
【請求項２】
表２に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳマグネシウム型とグルタチオンとの複合体。
【請求項３】
表３に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２αとの複合体。
【請求項４】
表４に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２αとの複合体。
【請求項５】
表５に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２αとの複合体。
【請求項６】
表６に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２αとの複合体。
【請求項７】
表７に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び1-アミノ-4-{4-[4-クロロ-6-(2-スルホニルフェニルアミノ)-[1,3,5]トリアジン-2-イルメチル]-3-スルホフェニルアミノ}-9,10-ジオキソ-9,10-ジヒドロアンスラセン-2-スルホン酸との複合体。
【請求項８】
表８に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び４−ベンズヒドリルオキシ−１−{３−（１Ｈ−テトラゾール−５−イル）−プロピル}ピペリジンとの複合体。
【請求項９】
表１に示す３次元構造座標を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳカルシウム型とグルタチオンとの複合体の結晶。
【請求項１０】
表２に示す３次元構造座標を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳマグネシウム型とグルタチオンとの複合体の結晶。
【請求項１１】
表３に示す３次元構造座標を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２αとの複合体の結晶。
【請求項１２】
表４に示す３次元構造座標を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２αとの複合体の結晶。
【請求項１３】
表５に示す３次元構造座標を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２αとの複合体の結晶。
【請求項１４】
表６に示す３次元構造座標を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２αとの複合体の結晶。
【請求項１５】
表７に示す３次元構造座標を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及びチバクロンブルー（1-アミノ-4-{4-[4-クロロ-6-(2-スルホニルフェニルアミノ)-[1,3,5]トリアジン-2-イルメチル]-3-スルホフェニルアミノ}-9,10-ジオキソ-9,10-ジヒドロアンスラセン-2-スルホン酸）との複合体の結晶。
【請求項１６】
表８に示す３次元構造座標を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び４−ベンズヒドリルオキシ−１−{３−（１Ｈ−テトラゾール−５−イル）−プロピル}ピペリジンとの複合体の結晶。
【発明の詳細な説明】
【０００１】
【発明の属する技術分野】
本発明はヒト由来造血器型プロスタグランジンＤ合成酵素（以下プロスタグランジンＤ合成酵素をＰＧＤＳと称することがある）の３次元立体構造、及び該３次元立体構造を用いてＰＧＤＳの阻害剤を設計する方法に関する。
【０００２】
【従来の技術】
プロスタグランジンＤ２（ＰＧＤ２）は生体内でプロスタグランジンＨ２（ＰＧＨ２）からＰＧＤＳによって合成される。ＰＧＤＳには２種類の酵素、脳型ＰＧＤＳ及び造血器型ＰＧＤＳが存在する。造血器型ＰＧＤＳは、酵素反応にグルタチオンを絶対的に要求する。一方、脳型ＰＧＤＳはグルタチオン以外の他のチオール試薬の存在下にも酵素反応を示す。
ＰＧＤ２は中枢神経系においては脳型ＰＧＤＳにより合成され、睡眠誘発、体温低下、黄体ホルモン分泌の抑制、痛みや匂いの応答の調節などの作用を有する。また末梢組織では、造血器型ＰＧＤＳにより合成され、肥満細胞から放出されるアレルギー反応のメディエーターとして、末梢血管の拡張、気管支収縮、血小板凝集阻害などの生理作用を有することが知られている。
【０００３】
肥満細胞から放出されるプロスタグランジンD２はアレルギーの伝達物質であることが知られている（Lewis, R. A., Soter, N. A., Diamond, P. T., Austen, K. F., Oates, J. A. & Roberts, L. J. Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. J. Immunol., 129, 1627-1631 (1982).）。プロスタグランジンD2のレセプター蛋白（ＤＰ受容体）のノックアウトマウスは、アレルギー反応が著しく軽減されることが報告されている（Matsuoka, T., Hirata, M., Tanaka, H., Takahashi, Y., Murata, T., Kabashima, K., Sugimito, Y., Kobayashi, T., Ushikubi, F., Aze, Y., Yoshida, N., Honda, Y., Nagai, H. & Narumiya, S. Prostaglandin D2 as a mediator of allergic ashma.  Science, 287, 2013-2017 (2000).）。アレルギー反応に関与するＴｈ２リンパ細胞、好酸球、好塩基球には、もう一つのプロスタグランジンD2レセプター（ＣＲＴＨ２受容体）が存在し、これらの炎症性細胞のケモタキシスを促進する（Hirai, H., Tanaka, K., Yoshie, O., Ogawa, K., Kenmotsu, K., Takamori, Y., Ichimasa, M., Sugamura, K., Nakamura, M., Takano, S., and Nagata, K., Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils and basophils via seven-transmembrane receptor CRTH2, J. Exp. Med., 193, 255-261 (2001))。肥満細胞（Urade, Y., Ujihara, M., Horiguchi, Y., Igarashi, M., Nagata, A., Ikai, K. and Hayaishi, O. Mast cells contain spleen-type prostaglandin D synthase, J. Biol. Chem., 265, 371-375 (1990))、及びヒトＴｈ２リンパ細胞（Tanaka, K., Ogawa, K., Sugamura, K., Nakamura, M., Takano, S. and Nagata, K., Differential production of prostaglandin D2 by human helper T cell subsets, J. Immunol., 164, 2277-2280 (2000))におけるプロスタグランジンD2の合成は造血器型ＰＧＤＳによって行なわれる。
ＰＧＤＳの酵素活性を阻害する化合物を得ることができれば、ＰＧＤ２の合成を制御でき、抗アレルギー薬、睡眠調節薬、抗肥満薬を得ることが可能となる。
【０００４】
近年、タンパク質の立体構造から薬物を設計する試みがなされている。しかしながら現在までヒト由来造血器型ＰＧＤＳの立体構造の決定に成功したものはいなかった。このためヒト由来造血器型ＰＧＤＳの阻害剤をその立体構造から設計することは困難であった。
【０００５】
【発明が解決しようとする課題】
本発明は、ヒト由来造血器型ＰＧＤＳの３次元立体構造を明らかにし、その３次元立体構造を用いてＰＧＤＳの阻害剤を設計する方法を提供することを目的とする。
【０００６】
【課題を解決するための手段】
本発明者は、ヒト由来造血器型ＰＧＤＳ（金属イオンとしてカルシウムイオン（以下「カルシウム型」と言う）又はマグネシウムイオン（以下「マグネシウム型」と言う）を有する）、ＰＧＤＳの補酵素であるグルタチオン（ＧＳＨ）、及びＰＧＤＳの基質であるプロスタグランジンＨ２（ＰＧＨ２）のアナログ又はＰＧＤＳの阻害剤の複合体の結晶を調製することに成功し、次いでＸ線結晶構造解析の手法によりこれら複合体の３次元立体構造を明かにすることに始めて成功した。
【０００７】
本発明は、表１に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳカルシウム型とグルタチオンとの複合体に関する。
【０００８】
本発明は、表２に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳマグネシウム型とグルタチオンとの複合体にも関する。
【０００９】
本発明は、表３に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２α（以下「Ｕ４６」と呼ぶことがある）との複合体にも関する。
Ｕ４６は、式：
【化１】
0004071477.tif 000002
よって表されるＰＧＤＳの基質であるプロスタグランジンＨ２のアナログである。
【００１０】
本発明は、表４に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及びＵ４６との複合体にも関する。
【００１１】
本発明は、表５に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２α（以下「Ｕ４４」と呼ぶことがある）との複合体にも関する。
Ｕ４４は、式：
【化２】
0004071477.tif 000003
によって表されるＰＧＤＳの基質であるプロスタグランジンＨ２のアナログである。
【００１２】
本発明は、表６に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及びＵ４４との複合体にも関する。
【００１３】
本発明は、表７に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及びチバクロンブルー（登録商標）（1-アミノ-4-{4-[4-クロロ-6-(2-スルホ-フェニルアミノ)-[1,3,5]トリアジン-2-イルメチル]-3-スルホ-フェニルアミノ}-9,10-ジオキソ-9,10-ジヒドロ-アントラセン-2-スルホン酸）との複合体にも関する。
チバクロンブルーは、式：
【化３】
0004071477.tif 000004
によって表され、ＰＧＤＳの阻害剤であることが知られている化合物である（Thomson, A. M., Meyer, D. J. & Hayes, J. D. Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase. Biochem. J.,333, 317-325 (1998) ）。
【００１４】
本発明は、表８に示す３次元構造座標によって表される立体構造を有する、配列番号１のアミノ酸配列を有するヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び４−ベンズヒドリルオキシ−１−{３−（１Ｈ−テトラゾール−５−イル）−プロピル}ピペリジン（以下で「ＨＱＬ−７９」と呼ぶことがある）との複合体にも関する。
ＨＱＬ−７９は、式：
【化４】
0004071477.tif 000005
によって表され、抗アレルギー活性を有することが知られている化合物である（Matsushita N, Hizue M, Aritake K, Hayashi K, Takada A, Mitsui K, Hayashi M, Hirotsu I, Kimura Y, Tani T and Nakajima H, Pharmacological studies on the novel antiallergic drug HQL-79: I. Antiallergic and antiasthmatic effects in various experimental models. Japanese Journal of Pharmacology, 78, 1-10 (1998) ）。
【００１５】
本発明は、更に、表１〜８に示される３次元構造座標よりなる群から選択される少なくとも１の３次元構造座標の、ヒト由来造血器型ＰＧＤＳを阻害する化合物の選定における使用に関する。
本発明は、ヒト由来造血器型ＰＧＤＳの阻害剤の選定方法であって、
（ａ）ヒト由来造血器型ＰＧＤＳの活性部位を特徴づける、表１〜８に示される３次元構造座標よりなる群から選択される少なくとも１の３次元構造座標を提供し；
（ｂ）候補化合物の立体構造を提供し；
（ｃ）候補化合物を活性部位に適合させて候補化合物を選択する
ことを含む方法にも関する。
【００１６】
ヒト由来造血器型ＰＧＤＳの活性部位を構成するアミノ酸残基は、Tyr8, Phe9, Asn10, Met11, Arg12, Gly13, Arg14, Ala15, Glu16, Leu17,Trp39, Pro40, Glu41, Ile42, Lys43,Gly49, Lys50, Ile51, Pro52, Ile53,His62, Gln63, Ser64, Leu65,Asp93, Thr94, Leu95, Asp96, Asp97, Phe98, Met99, Ser100, Cys101, Phe102,Phe103, Trp104, Ala105, Glu106, Lys107, Lys108, Gln109, Asp110, Val111, Lys112,Glu113, Gln114, Met115, Phe116,Tyr152, Trp153, Glu154, Ile155, Leu156, Ser157, Thr158, Thr159, Leu160, Leu161, Val162, Phe163,Thr197, Lys198, Leu19である。ＰＧＤＳの活性にはＰＧＤＳタンパク質の外にグルタチオン及び金属イオン（カルシウムイオン又はマグネシウムイオン）が関与する。
「適合させる」とは、上記の活性部位に形状的及びエネルーギー的に適合させることを言い、候補化合物が造血器型ＰＧＤＳの結合部位に結合する際の接触表面積が最大となるような化合物を選択し、さらに候補化合物と造血器型プロスタグランジンＤ合成酵素の結合部位の化学的結合が最大となる化合物を選択する。
【００１７】
好ましい態様では選択された阻害剤をプロスタグランジンＨ2の存在下に造血器型ＰＧＤＳと接触させて阻害効果を確認する。
更に、阻害剤が抗アレルギー活性、睡眠調節活性、及び抗肥満活性よりなる群から選択される少なくとも１の生物学的活性を有するか否かを測定する。
【００１８】
【発明の実施の形態】
（I）ヒト由来造血器型プロスタグランジンＤ合成酵素
ヒト由来造血器型ＰＧＤＳのアミノ酸配列は公知であり、その製造方法も開示されている（特開平９−３２２７７３号公報）。ヒト由来造血器型ＰＧＤＳはヒトの組織から得ることも可能であるが、遺伝子組換え技術により製造するのが便利である。
例えば、ヒト由来造血器型ＰＧＤＳのアミノ酸配列（配列番号１）をコードするｃＤＮＡをＴ７ポリメラーゼ遺伝子のプロモーターのコントロール下に含有する発現プラスミド（ｐＴ７−７ｈＨＰＧＤＳ）を構築し（特開平９−３２２７７３号公報）、該プラスミドで大腸菌ＢＬ２１（ＤＥ３）を改変塩化カルシウム法（Inoue et al., Gene 96, 23-28 (1990)）により形質転換する。発現プラスミド（ｐＴ７−７ｈＨＰＧＤＳ）で形質転換された大腸菌ｐＹＫ１は受託番号、ＦＥＲＭ  ＢＰ−５４８９の下、独立行政法人産業技術総合研究所に寄託されている。形質転換体、大腸菌ｐＹＫ１をＬＢ培地（５０μｇ／ｍｌアンピシリンを含む）にて３７℃で一晩培養した後、ＩＰＴＧ（イソプロピルチオ−β−Ｄ−ガラクトシド）（終濃度０．４ｍＭ）を添加してさらに４〜６時間培養する。
培養終了後、大腸菌を超音波破砕し、遠心分離機により13,000rpm、４℃、15分で沈殿物を取り除く。次に硫安分画を行う。この際、40%から60%の画分を確保し、50mMリン酸ナトリウム緩衝液で透析を行う。Glutathion Sephalose 4Bカラムに展開し、アフィニティークロマトグラフィーにて精製する。
【００１９】
（II）ヒト由来造血器型プロスタグランジンＤ合成酵素複合体の結晶
タンパク質の結晶化は目的のタンパク質の溶液に沈殿剤を添加する、又は溶液量を溶媒の蒸発等により減少させてタンパク質を溶解状態から非溶解状態にする場合にある特定の条件で結晶として析出する性質を利用している。
本発明者はヒト由来造血器型ＰＧＤＳ複合体がハンギングドロップ蒸気拡散法（未発表）により首尾よく結晶化することを見出した。ハンギングドロップ蒸気拡散法とは蛋白質溶液と沈殿剤溶液の混合溶液をガラス板上に表面張力でぶら下げ、より濃い濃度の沈殿剤溶液とともに密閉空間に閉じ込めて、蛋白質の結晶を作成する方法である。蒸気が拡散するので、沈殿剤の濃度が徐々に上昇し、結晶が得られる。。大きい結晶を得る場合には１回目の結晶化で得た０．０１ｍｍ程度の結晶を選び、マクロシ−ディング法（Stura, E. A. & Wilson, L. A. Applications of the streak seeding technique in protein crystallization. J. of Crystal Growth, 110, 270-282 (1991). ）を用いて再度結晶化を行なうことにより、０．３ｘ０．３ｘ１．５ｍｍ程度のＸ線回折実験に最適な結晶を再現性よく得ることができる。
本発明の８つのヒト由来造血器型ＰＧＤＳ複合体の結晶調製の条件を以下に例示する。
【００２０】
（１）ヒト由来造血器型ＰＧＤＳカルシウム型とグルタチオンとの複合体
0004071477.tif 000006
【００２１】
（２）ヒト由来造血器型ＰＧＤＳマグネシウム型とグルタチオンとの複合体
0004071477.tif 000007
【００２２】
（３）ヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２α（Ｕ４６）との複合体
0004071477.tif 000008
【００２３】
（４）ヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２α（Ｕ４６）との複合体
0004071477.tif 000009
【００２４】
（５）ヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２α（Ｕ４４）との複合体
0004071477.tif 000010
【００２５】
（６）ヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２α（Ｕ４４）との複合体
0004071477.tif 000011
【００２６】
（７）ヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及びチバクロンブルー（1-アミノ-4-{4-[4-クロロ-6-(2-スルホ-フェニルアミノ)-[1,3,5]トリアジン-2-イルメチル]-3-スルホ-フェニルアミノ}-9,10-ジオキソ-9,10-ジヒドロ-アントラセン-2-スルホン酸）の複合体
0004071477.tif 000012
【００２７】
（８）ヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び４−ベンズヒドリルオキシ−１−{３−（１Ｈ−テトラゾール−５−イル）−プロピル}ピペリジン（ＨＱＬ−７９）との複合体
0004071477.tif 000013
【００２８】
（III）ヒト由来造血器型プロスタグランジンＤ合成酵素複合体の３次元構造座標
（II)で得られるヒト由来造血器型ＰＧＤＳ複合体の結晶から、Ｘ線結晶構造解析の手法によりこれら複合体の三次元構造を明らかにする。
SPring-8の理研ビームラインBL44XUにおいて、上記（ＩＩ）（１）で得たヒト由来造血器型ＰＧＤＳカルシウム型の水銀誘導体結晶について異常分散効果を考慮に入れたデータ収集を行った。1.009Å、1.04Å、1.10Åの３波長の放射光を使ってデータ収集を行い、パターソン関数の解析から水銀の位置を８ヶ所計算した。これをプログラムMLPHARE（Otwinowski, Z. in Proceedings of CCP4 Study Weekend, Isomorphous Replacement and Anomalous Scattering, edited by Sawyer, L., Issacs, N., and Bailey, S. [Science and Engineering Research Council (England) Daresbury Lab., Warrington, U.K.], pp. 80-86 (1993)）を用いて位置の精密化を行い、酵素の電子密度を得た。グラフィックスワークステーション上で酵素モデルを構築し、精密化プログラムCNS（Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T. & Warren, G. L. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Cryst., D54, 905-921 (1998)を参照.）を用いて、ヒト由来造血器型ＰＧＤＳカルシウム型の酵素モデルを高精度で得た。
その他の構造モデルは、最初に得たカルシウム型のモデルを基に、構造精密化プログラムCNSで、すべて高分解能でモデルを得た。
(II)の（１）〜（８）で調製した結晶について得られた結晶学的データを以下に示す。
【００２９】
0004071477.tif 000014
【００３０】
0004071477.tif 000015
【００３１】
ヒト由来造血器型プロスタグランジンＤ合成酵素（ＰＧＤＳ）カルシウム型とグルタチオンとの複合体の３次元構造座標を表１に、ヒト由来造血器型ＰＧＤＳマグネシウム型とグルタチオンとの複合体の３次元構造座標を表２に、ヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２αとの複合体の３次元構造座標を表３に、ヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２αとの複合体の３次元構造座標を表４に、ヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２αとの複合体の３次元構造座標を表５に、ヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２αとの複合体の３次元構造座標を表６に、ヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及びチバクロンブルーとの複合体の３次元構造座標を表７に、ヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び４−ベンズヒドリルオキシ−１−{３−（１Ｈ−テトラゾール−５−イル）−プロピル}ピペリジンとの複合体の３次元構造座標を表８に示す。
各表はプロテインデータバンク（Protein Data Bank, http://www.rcsb.org/pdb/、アメリカ）所定の書式に従って原子の３次元構造座標を表示している。第１列のＡＴＯＭはタンパク質を構成する原子であることを示し、第２列は蛋白質を構成する１番のアミノ酸から順に、原子ごとに連続してつけた番号であり、第３列は蛋白質を構成する原子の種類を示す。例えば、Ｃα炭素原子はＣＡ，アミド窒素原子はＮ，カルボニル炭素原子はＣ，カルボニル酸素原子はＯと表記される。第４列はアミノ酸の種類を３文字表記法で示す。第５列は分子の種類を示す。第６列はアミノ酸配列における位置番号を示す。第７〜９列は順に３次元構造座標Ｘ，Ｙ，Ｚを示す。第１０列は占有率と呼ばれる項で通常は１である。第１１列は温度因子であり、第１２列は第５列と同様に分子の種類を示す。
【００３２】
（IV）ヒト由来造血器型プロスタグランジンＤ合成酵素複合体の立体構造及び結合部位
（１）ヒト由来造血器型ＰＧＤＳカルシウム型とグルタチオンとの複合体
プロスタグランジンＤ合成酵素はダイマーを形成し、ダイマーの中心にカルシウムイオンが存在する（図１）。カルシウムはグルタチオンの結合に影響しないが、ＰＧＤＳ酵素の反応速度を上昇させる因子である。グルタチオンはＰＧＤＳのTyr8, Arg14, Trp39, Gly49, Lys50, Ile51, Pro52, Gln63, Ser64に結合している。
（２）ヒト由来造血器型ＰＧＤＳマグネシウム型とグルタチオンとの複合体
ダイマーの中心の金属イオンがカルシウムイオンからマグネシウムイオンに変化したことに伴って、金属イオンに配位する水分子の配位構造が大きく変化している。マグネシウムはグルタチオンのＰＧＤＳ酵素に対する親和性を３倍以上上昇させる因子である。
（３）ヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２α（Ｕ４６）との複合体
この複合体では、ダイマーの中心にカルシウムイオンが存在している点は（１）と同一であるが、さらに基質類似物であるU46が結合している。U46はＰＧＤＳのTyr8, Gly13, Arg14, Gln36, Trp104, Gln109, Lys112, Tyr152, Lys198, 及びLeu199,並びに GSHに結合しており、U46のカルボキシル基は、Gln109, Lys112, Lys198のいずれかと水素結合する。U46のC11位の酸素原子はGSHのS原子から4.6Åの距離に位置する。U46のω鎖は基質の結合部位の最も深い部分にあるTyr152にファンデルワールス接触の距離まで近づいている。
（４）ヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２α（Ｕ４６）との複合体
ダイマーの中心にマグネシウムが存在する点で（３）とは異なる。U46のα鎖はGln109, Lys112, Lys198の近傍にいるものの、水素結合はしておらず、ファンデルワールス接触している。U46の11位の酸素原子は水分子を介してGln36と水素結合していた。ω鎖のOH基は回転したArg14と水素結合し、ω鎖はポケットの外に飛び出している。また、U46の溶媒分子である、エーテルがTrp104とU46分子の間の隙間に結合していた。
（５）ヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２α（Ｕ４４）との複合体
基質類似物U44が結合している点で、これまでの（１）〜（４）とは異なっている。カルシウム型の構造では、U44の結合部位は、U46の結合部位と同じであるが、水素結合の様式が異なる。同じカルシウム型であっても、U46とは異なって、α鎖はGln109, Lys112, Lys198のすべてと水素結合し、9位の酸素原子は、Gln36と水分子を介して水素結合していた。ω鎖は３）の構造とは異なり、奥のTyr152からは５Å程度離れている。
（６）ヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２α（Ｕ４４）との複合体
基質類似物Ｕ４４との複合体である点では、（５）と同一であるが、ダイマーの中心に位置する金属イオンがマグネシウムイオンである点で（５）とは異なる。
（７）ヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及びチバクロンブルーの複合体
阻害剤チバクロンブルーとの複合体である点で、これまでの６つの構造とは異なっている。ダイマーの中心金属のイオンはカルシウムイオンである。チバクローンブルーはＰＧＤＳのPhe9, Gly10, Gly13, Arg14, Gln36, Met99, Ser100, Trp104, Glu106, Lys107, Gln109, Lys112, Tyr152, Cys156, Lys198,及び Leu199, 並びにGSHに結合している。
（８）ヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び４−ベンズヒドリルオキシ−１−{３−（１Ｈ−テトラゾール−５−イル）−プロピル}ピペリジン（ＨＱＬ−７９）との複合体
阻害剤ＨＱＬ−７９との複合体である点で(1)から(6)とは異なり、また(7)とは異なる阻害剤が結合している。ダイマーの中心にマグネシウムイオンが結合しており、HQL-79の結合によりインデューストフィット現象が起こって、結晶の空間群がP21からP1に変化している。HQL-79は、ＰＧＤＳのTyr8, Phe9, Arg14, Met99, Phe102, Trp104, Tyr152, Ile155, Thr159, Phe163,及び Leu199, 並びにGSHに結合している。
【００３３】
（V) ヒト由来造血器型プロスタグランジンＤ合成酵素の阻害剤作成のための３次元構造座標の使用
表１〜８に示す３次元構造座標を用いて、ヒト由来造血器型ＰＧＤＳを阻害する化合物を選定することができる。
本発明は、ヒト由来造血器型ＰＧＤＳの阻害剤の選定方法であって、
（ａ）ヒト由来造血器型ＰＧＤＳの活性部位を特徴づける、表１〜８に示される３次元構造座標よりなる群から選択される少なくとも１の３次元構造座標を提供し；
（ｂ）候補化合物の立体構造を提供し；
（ｃ）候補化合物を活性部位に適合させて候補化合物を選択する
ことを含む方法にも関する。
【００３４】
上記のようにヒト造血器型ＰＧＤＳの活性部位を構成するアミノ酸残基は、Tyr8, Phe9, Asn10, Met11, Arg12, Gly13, Arg14, Ala15, Glu16, Leu17,Trp39, Pro40, Glu41, Ile42, Lys43,Gly49, Lys50, Ile51, Pro52, Ile53,His62, Gln63, Ser64, Leu65,Asp93, Thr94, Leu95, Asp96, Asp97, Phe98, Met99, Ser100, Cys101, Phe102,Phe103, Trp104, Ala105, Glu106, Lys107, Lys108, Gln109, Asp110, Val111, Lys112,Glu113, Gln114, Met115, Phe116,Tyr152, Trp153, Glu154, Ile155, Leu156, Ser157, Thr158, Thr159, Leu160, Leu161, Val162, Phe163,Thr197, Lys198, Leu19である。
【００３５】
３次元立体構造情報を基に、市販の化合物を１つずつ、酵素の活性部位への結合が最適な方位で起こるように、エネルギーの最小化を各種プログラムを用いて行う。これを市販の化合物すべてにおいて自動的に行い、自由エネルギーで比較することによって、結合しやすい化合物を選定する。これで得られた化合物を基本骨格とし、更なる安定な誘導体をプログラムによってデザインし、より安定な化合物を合成し、酵素の新規な阻害剤を開発する。
【００３６】
阻害剤の設計を行うにはコンピューターを用いて行なうことが好ましい。この際に用いられるコンピューターは、例えばシリコングラフィックス社によって供給されているワークステーションＩｎｄｉｇｏ２などが好適であるが、これに限定されるものではなく、適当なプログラムが動作するように調整されているコンピューターであればよい。また、コンピューターの記憶媒体にも特に制限はない。設計に用いるプログラムは、例えばモレキュラーシミュレーション社から市販されているコンピューター・プログラムＩｎｓｉｇｈｔ  ＩＩを用いることで達成できる。特に、該目的のために特別に作成されたＩｎｓｉｇｈｔ  ＩＩのモジュールであるＬｕｄｉやＤＯＣＫといったプログラムを単独又は組み合わせて用いることで、より容易に同定、検索、評価又は設計することができる。
【００３７】
阻害剤の設計には、概念的に２つの段階がある。最初の段階は、当業者においてリード化合物と称される薬物設計の出発点となる化合物を見つけだす段階である。次の段階は、そのリード化合物から出発してより活性が優れる、体内動態が優れる、毒性や副作用の少ないなど、医薬品としてより優れた性質を持つ化合物を見いだすリード化合物の最適化の過程である。
【００３８】
本発明が提供するＰＧＤＳ複合体の構造座標を用いてリード化合物を見つけだす段階は、例えば複数の化合物の構造が入力してあるコンピューター中のデータベースを利用して、データベース中の化合物とＰＧＤＳの３次元構造上の相互作用を逐次、視覚的方法によって選別する方法、又はコンピューターにより結合のエネルギーの大きさを逐次計算し、安定にＰＧＤＳと結合する化合物をデータベースの中から探し出す方法などによって達成される。化合物の構造のデータベースは３次元構造座標が決定され入力されていることが望ましいが、低分子化合物の場合には、そのコンフォーメーションは比較的自由に変化されうるし、各コンフォメーションの３次元構造座標を計算で導くことも比較的短時間で可能であるので、３次元構造座標のデータベースでなくてもよい。この場合は、低分子化合物の化学的な共有結合情報をデータベースに入力する。
【００３９】
具体的には、視覚的方法では、まずコンピューターの画面上にＰＧＤＳ複合体を、本発明の構造座標に従って表示する。この際、コンピューターの画面上にクリスタル・アイを用いるなどの３次元表記をしてもよいが、必ずしも３次元表記を用いなくても視覚的な検討は可能である。
【００４０】
考慮すべき化学的相互作用は静電相互作用、疎水性相互作用、水素結合、ファンデルワールス相互作用などである。すなわち、該化合物の３次元空間での構造が、その官能基群においてカルボキシル基、ニトロ基、ハロゲン基などの陰性電荷を帯びやすい基が、ＰＧＤＳのリジン、アルギニン、ヒスチジンといった正電荷を持つアミノ酸残基に相互作用するように、アミノ基、イミノ基、グアニジル基などの陽性電荷を帯びやすい基が、ＰＧＤＳのグルタミン酸、アスパラギン酸といった負電荷を持つアミノ酸残基に相互作用するように、脂肪族基や芳香族基といった疎水性の官能基が、アラニン、ロイシン、イソロイシン、バリン、プロリン、フェニルアラニン、トリプトファン及びメチオニンといった疎水性のアミノ酸残基と相互作用するように、水酸基、アミド基などの水素結合に関与する基が、ＰＧＤＳの主鎖や側鎖部分と水素結合ができるように、更には、該化合物とＰＧＤＳとの結合において立体的な障害が生じないように、また、更には、空隙部分がなるべくできないように空隙部分が充填され、ファンデルワールス相互作用が大きくなるようになど、相互作用に好ましい構造になっているかを総合的に考慮することである。このように、静電相互作用、疎水性相互作用、ファンデルワールス相互作用、水素結合などやその他の因子を、コンピューター画面上で視覚的に総合的に考慮して、最終的に該化合物がリード化合物として適当であるか否かの判断を行う。
【００４１】
コンピューターによるエネルギー評価による方法では、分子力場計算を用いて化合物と、ＰＧＤＳとの結合のエネルギーを求める。その計算をデータベースの中の各化合物に適用し、安定に結合できるリード化合物となりうる化合物を、このデータベースの中から求める。分子力場計算に用いる力場は、プログラムＩｎｓｉｇｈｔ  ＩＩのＤＩＳＣＯＶＥＲモジュールにある、蛋白質に最適化されたＡＭＢＥＲの力場、ＣＶＦＦなどを利用できる。また、Ｉｎｓｉｇｈｔ  ＩＩのＬｕｄｉなどコンピューター・プログラムによっては、蛋白質分子において相互作用するアミノ酸残基の３次元構造座標を与えると、自動的にリード化合物の候補を出力するものもあり、本発明の方法に用いることが可能である。また、視覚的検討と、エネルギーを考慮した検討は厳密に区別されるものではなく、それぞれの手法を適宜に組み合わせて用いることも有用である。
【００４２】
次の段階である、リード化合物の最適化を行う方法は、あらかじめリード化合物が上記の方法で見いだされている場合に、そのリード化合物を更に優れた分子、例えば阻害剤として更に生物活性の高い化合物や、医薬品として経口投与を考えた場合に有利な構造を有する分子などへ最適化する目的で用いられる。リード化合物とＰＧＤＳの化学的結合の実態を明らかにすることによって、リード化合物とＰＧＤＳの相互作用において最適ではない相互作用部位を直接見いだし、その部位に最適な官能基を有する化合物を新たに設計することが可能となり、より最適化された化合物が設計できる。
【００４３】
コンピューターによる視覚的検討の場合は、まず、リード化合物の３次元構造座標と本発明のＰＧＤＳの３次元構造座標を、分子の３次元構造座標を表現するコンピューター・プログラムが動作するコンピューター又はそのコンピューターの記憶媒体に入力して、コンピューター画面上でリード化合物とＰＧＤＳの複合体モデルを表示する。この際、コンピューターの画面上に前述のようなクリスタル・アイを用いるなどの３次元表記をしてもよいが、必ずしも３次元表記を用いなくても視覚的な検討は可能である。そして、リード化合物がＰＧＤＳと更に好ましく相互作用できるように、若しくは相互作用を保持させたまま、より体内動態の優れた化合物へと改変することが、論理的な化合物の設計である。
【００４４】
考慮すべき化学的相互作用はリード化合物を見つけだす場合と同様であり、最終的にリード化合物から、阻害剤としてより好ましい性質を持つ化合物を新たに設計する。
【００４５】
コンピューターによるエネルギー評価による方法では、分子力場計算を用いて、リード化合物から設計された新たな化合物とＰＧＤＳとの結合のエネルギーを求め、該設計の妥当性を判断する。更には、溶媒分子などもモデルに加え、分子動力学法を用いて自由エネルギーを求め、安定に結合できる化合物へ誘導する方法もある。分子力場計算に用いる力場は、プログラムＩｎｓｉｇｈｔ  ＩＩのＤＩＳＣＯＶＥＲモジュールにある、蛋白質に最適化されたＡＭＢＥＲの力場、ＣＶＦＦなどを利用できる。
視覚的検討と、エネルギー評価による方法を適宜に組み合わせて用いてもよい。
【００４６】
以上のようにして造血器型ＰＧＤＳの阻害剤の候補化合物を選択した後、好ましくは該選択した化合物を基質（プロスタグランジンＨ２）存在下に該酵素と接触させて、該化合物の該酵素を阻害する能力を測定する（例えば、Shimizu, T., Yamamoto, S., and Hayaishi, O. (1979). Purification and properties of prostaglandin D synthetase from rat brain. J. Biol. Chem. 254, 5222-5228を参照）。
造血器型ＰＧＤＳの阻害剤は抗アレルギー薬、睡眠調節活性、及び抗肥満薬となり得るのでそれぞれの薬剤としての薬理活性を測定する。
抗アレルギー薬の薬理活性測定方法についてはFugner A, Bechtel W. D., Kuhn, F. J. and Mierau, J. In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneimittelforschung, 38, 1446-1453 (1988). Kamei, C., Izushi, K., Adachi, Y., Shimazawa, M. and Tasaka, K. Inhibitory effect of epinastine on the type II-IV allergic reactions in mice, rats and guinea pigs. Arzneimittelforschung, 41, 1150-1153 (1991)に記載されている。
睡眠調節薬の薬理活性測定方法についてはHuang, Z.-H., Qu, W.-M., Li, W.-D., Mochizuki, T., Eguchi, N., Watanabe, T., Urade, Y. & Hayaishi, O. Arousal effect f orexin A depends on activation of the histaminergic system. Proc. Natl. Acad. Sci. USA, 98, 9965-9970 (2001)に記載されている。抗肥満薬の薬理活性測定方法については、Ikeda H, Taketomi S, Sugiyama Y, Shimura Y, Sohda T, Meguro K & Fujita T. Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals. Arzneimittelforschung, 40, 156-162 (1990)  及びSohda T, Mizuno K, Momose Y, Ikeda H, Fujita T & Meguro K. Studies on antidiabetic agents. 11. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents. J. Med. Chem., 35, 2617-2626 (1992)に記載されている。
【００４７】
【表１】
ヒト由来造血器型ＰＧＤＳカルシウム型とグルタチオンとの複合体の３次元構造座標
ATOM   4966  N   TYR A   8      -2.182  -4.051  33.067  1.00 13.69   A
ATOM   4967  CA  TYR A   8      -0.772  -4.337  33.302  1.00 13.75   A
ATOM   4968  CB  TYR A   8       0.013  -3.029  33.442  1.00 12.77   A
ATOM   4969  CG  TYR A   8       1.519  -3.203  33.467  1.00 11.97   A
ATOM   4970  CD1 TYR A   8       2.186  -3.810  32.407  1.00 11.66   A
ATOM   4971  CE1 TYR A   8       3.576  -3.936  32.403  1.00 11.17   A
ATOM   4972  CD2 TYR A   8       2.279  -2.725  34.535  1.00 11.40   A
ATOM   4973  CE2 TYR A   8       3.666  -2.843  34.545  1.00 11.23   A
ATOM   4974  CZ  TYR A   8       4.307  -3.447  33.475  1.00 11.71   A
ATOM   4975  OH  TYR A   8       5.680  -3.555  33.475  1.00 12.03   A
ATOM   4976  C   TYR A   8      -0.651  -5.143  34.588  1.00 14.05   A
ATOM   4977  O   TYR A   8      -1.650  -5.413  35.253  1.00 14.34   A
ATOM   4978  N   PHE A   9       0.569  -5.539  34.932  1.00 14.40   A
ATOM   4979  CA  PHE A   9       0.793  -6.283  36.165  1.00 15.06   A
ATOM   4980  CB  PHE A   9       2.198  -6.887  36.177  1.00 15.16   A
ATOM   4981  CG  PHE A   9       2.369  -8.046  35.234  1.00 16.21   A
ATOM   4982  CD1 PHE A   9       3.275  -7.974  34.180  1.00 16.15   A
ATOM   4983  CD2 PHE A   9       1.633  -9.214  35.406  1.00 16.28   A
ATOM   4984  CE1 PHE A   9       3.450  -9.050  33.307  1.00 16.56   A
ATOM   4985  CE2 PHE A   9       1.797 -10.299  34.540  1.00 16.94   A
ATOM   4986  CZ  PHE A   9       2.708 -10.215  33.490  1.00 16.76   A
ATOM   4987  C   PHE A   9       0.644  -5.318  37.339  1.00 15.24   A
ATOM   4988  O   PHE A   9       0.482  -4.111  37.139  1.00 14.55   A
ATOM   4989  N   ASN A  10       0.692  -5.847  38.559  1.00 15.45   A
ATOM   4990  CA  ASN A  10       0.577  -5.003  39.742  1.00 15.61   A
ATOM   4991  CB  ASN A  10      -0.020  -5.775  40.925  1.00 16.21   A
ATOM   4992  CG  ASN A  10      -0.106  -4.926  42.189  1.00 16.84   A
ATOM   4993  OD1 ASN A  10      -0.304  -3.707  42.124  1.00 17.30   A
ATOM   4994  ND2 ASN A  10       0.032  -5.566  43.344  1.00 17.59   A
ATOM   4995  C   ASN A  10       1.940  -4.458  40.125  1.00 15.68   A
ATOM   4996  O   ASN A  10       2.594  -4.955  41.040  1.00 15.31   A
ATOM   4997  N   MET A  11       2.371  -3.438  39.396  1.00 15.55   A
ATOM   4998  CA  MET A  11       3.644  -2.784  39.650  1.00 15.24   A
ATOM   4999  CB  MET A  11       4.823  -3.726  39.351  1.00 17.25   A
ATOM   5000  CG  MET A  11       4.880  -4.298  37.949  1.00 19.23   A
ATOM   5001  SD  MET A  11       6.385  -5.318  37.662  1.00 22.67   A
ATOM   5002  CE  MET A  11       5.752  -6.968  37.938  1.00 21.71   A
ATOM   5003  C   MET A  11       3.705  -1.543  38.772  1.00 14.23   A
ATOM   5004  O   MET A  11       2.864  -1.363  37.894  1.00 13.37   A
ATOM   5005  N   ARG A  12       4.671  -0.669  39.031  1.00 13.48   A
ATOM   5006  CA  ARG A  12       4.804   0.537  38.227  1.00 12.43   A
ATOM   5007  CB  ARG A  12       5.841   1.480  38.844  1.00 12.14   A
ATOM   5008  CG  ARG A  12       5.472   1.978  40.246  1.00 12.08   A
ATOM   5009  CD  ARG A  12       6.475   3.012  40.757  1.00 11.93   A
ATOM   5010  NE  ARG A  12       7.833   2.474  40.769  1.00 12.08   A
ATOM   5011  CZ  ARG A  12       8.301   1.623  41.680  1.00 12.27   A
ATOM   5012  NH1 ARG A  12       7.520   1.210  42.671  1.00 12.04   A
ATOM   5013  NH2 ARG A  12       9.550   1.174  41.589  1.00 11.83   A
ATOM   5014  C   ARG A  12       5.232   0.080  36.838  1.00 12.15   A
ATOM   5015  O   ARG A  12       4.517   0.285  35.858  1.00 12.05   A
ATOM   5016  N   GLY A  13       6.393  -0.563  36.770  1.00 12.02   A
ATOM   5017  CA  GLY A  13       6.898  -1.068  35.509  1.00 11.77   A
ATOM   5018  C   GLY A  13       6.769  -0.128  34.328  1.00 11.54   A
ATOM   5019  O   GLY A  13       6.967   1.080  34.449  1.00 11.13   A
ATOM   5020  N   ARG A  14       6.418  -0.702  33.183  1.00 11.75   A
ATOM   5021  CA  ARG A  14       6.277   0.040  31.939  1.00 11.78   A
ATOM   5022  CB  ARG A  14       6.507  -0.912  30.766  1.00 12.75   A
ATOM   5023  CG  ARG A  14       7.908  -1.488  30.767  1.00 14.50   A
ATOM   5024  CD  ARG A  14       8.186  -2.373  29.566  1.00 15.97   A
ATOM   5025  NE  ARG A  14       9.622  -2.433  29.307  1.00 18.20   A
ATOM   5026  CZ  ARG A  14      10.303  -1.488  28.666  1.00 19.33   A
ATOM   5027  NH1 ARG A  14       9.678  -0.413  28.202  1.00 19.36   A
ATOM   5028  NH2 ARG A  14      11.613  -1.603  28.516  1.00 20.58   A
ATOM   5029  C   ARG A  14       4.945   0.753  31.770  1.00 11.74   A
ATOM   5030  O   ARG A  14       4.748   1.488  30.801  1.00 11.56   A
ATOM   5031  N   ALA A  15       4.031   0.548  32.709  1.00 11.10   A
ATOM   5032  CA  ALA A  15       2.728   1.191  32.618  1.00 10.68   A
ATOM   5033  CB  ALA A  15       1.644   0.237  33.111  1.00 10.84   A
ATOM   5034  C   ALA A  15       2.665   2.492  33.400  1.00 10.23   A
ATOM   5035  O   ALA A  15       1.789   3.322  33.157  1.00 10.48   A
ATOM   5036  N   GLU A  16       3.600   2.679  34.327  1.00  9.72   A
ATOM   5037  CA  GLU A  16       3.618   3.870  35.169  1.00  9.10   A
ATOM   5038  CB  GLU A  16       4.808   3.809  36.132  1.00  9.10   A
ATOM   5039  CG  GLU A  16       4.692   4.729  37.336  1.00  9.09   A
ATOM   5040  CD  GLU A  16       3.527   4.369  38.243  1.00  9.08   A
ATOM   5041  OE1 GLU A  16       2.920   3.291  38.061  1.00  9.56   A
ATOM   5042  OE2 GLU A  16       3.218   5.163  39.150  1.00  9.58   A
ATOM   5043  C   GLU A  16       3.646   5.194  34.409  1.00  9.31   A
ATOM   5044  O   GLU A  16       3.032   6.170  34.837  1.00  8.78   A
ATOM   5045  N   ILE A  17       4.361   5.237  33.288  1.00  9.01   A
ATOM   5046  CA  ILE A  17       4.435   6.471  32.517  1.00  8.95   A
ATOM   5047  CB  ILE A  17       5.388   6.335  31.303  1.00  9.06   A
ATOM   5048  CG2 ILE A  17       4.929   5.211  30.385  1.00  8.42   A
ATOM   5049  CG1 ILE A  17       5.449   7.658  30.531  1.00  8.92   A
ATOM   5050  CD1 ILE A  17       5.944   8.827  31.354  1.00  9.68   A
ATOM   5051  C   ILE A  17       3.038   6.861  32.044  1.00  9.27   A
ATOM   5052  O   ILE A  17       2.701   8.044  31.989  1.00  9.18   A
ATOM   5242  N   TRP A  39      -2.568 -14.235  33.625  1.00 32.11   A
ATOM   5243  CA  TRP A  39      -1.844 -13.679  32.486  1.00 31.66   A
ATOM   5244  CB  TRP A  39      -0.384 -13.406  32.876  1.00 30.89   A
ATOM   5245  CG  TRP A  39       0.496 -12.996  31.726  1.00 30.01   A
ATOM   5246  CD2 TRP A  39       0.197 -12.029  30.710  1.00 29.51   A
ATOM   5247  CE2 TRP A  39       1.310 -11.981  29.840  1.00 29.33   A
ATOM   5248  CE3 TRP A  39      -0.901 -11.197  30.449  1.00 29.25   A
ATOM   5249  CD1 TRP A  39       1.741 -13.478  31.440  1.00 29.80   A
ATOM   5250  NE1 TRP A  39       2.237 -12.875  30.308  1.00 29.45   A
ATOM   5251  CZ2 TRP A  39       1.356 -11.136  28.726  1.00 29.02   A
ATOM   5252  CZ3 TRP A  39      -0.854 -10.356  29.340  1.00 28.91   A
ATOM   5253  CH2 TRP A  39       0.269 -10.333  28.493  1.00 28.96   A
ATOM   5254  C   TRP A  39      -1.892 -14.593  31.255  1.00 31.85   A
ATOM   5255  O   TRP A  39      -2.215 -14.142  30.156  1.00 31.82   A
ATOM   5256  N   PRO A  40      -1.571 -15.888  31.424  1.00 31.95   A
ATOM   5257  CD  PRO A  40      -1.187 -16.569  32.675  1.00 32.13   A
ATOM   5258  CA  PRO A  40      -1.586 -16.839  30.306  1.00 32.00   A
ATOM   5259  CB  PRO A  40      -1.477 -18.186  31.007  1.00 32.11   A
ATOM   5260  CG  PRO A  40      -0.591 -17.866  32.170  1.00 31.99   A
ATOM   5261  C   PRO A  40      -2.830 -16.740  29.427  1.00 31.94   A
ATOM   5262  O   PRO A  40      -2.734 -16.751  28.200  1.00 32.11   A
ATOM   5263  N   GLU A  41      -3.995 -16.645  30.060  1.00 31.73   A
ATOM   5264  CA  GLU A  41      -5.258 -16.542  29.338  1.00 31.51   A
ATOM   5265  CB  GLU A  41      -6.433 -16.620  30.319  1.00 32.22   A
ATOM   5266  CG  GLU A  41      -7.807 -16.488  29.668  1.00 33.37   A
ATOM   5267  CD  GLU A  41      -8.272 -17.772  29.001  1.00 34.21   A
ATOM   5268  OE1 GLU A  41      -7.544 -18.301  28.131  1.00 34.63   A
ATOM   5269  OE2 GLU A  41      -9.374 -18.251  29.351  1.00 34.59   A
ATOM   5270  C   GLU A  41      -5.344 -15.236  28.550  1.00 30.86   A
ATOM   5271  O   GLU A  41      -5.612 -15.240  27.347  1.00 30.86   A
ATOM   5272  N   ILE A  42      -5.116 -14.122  29.239  1.00 29.82   A
ATOM   5273  CA  ILE A  42      -5.174 -12.797  28.624  1.00 28.89   A
ATOM   5274  CB  ILE A  42      -4.914 -11.697  29.673  1.00 29.12   A
ATOM   5275  CG2 ILE A  42      -4.936 -10.323  29.011  1.00 29.10   A
ATOM   5276  CG1 ILE A  42      -5.973 -11.780  30.776  1.00 29.24   A
ATOM   5277  CD1 ILE A  42      -5.692 -10.894  31.969  1.00 29.54   A
ATOM   5278  C   ILE A  42      -4.162 -12.637  27.492  1.00 28.04   A
ATOM   5279  O   ILE A  42      -4.476 -12.078  26.442  1.00 27.96   A
ATOM   5280  N   LYS A  43      -2.949 -13.128  27.718  1.00 27.12   A
ATOM   5281  CA  LYS A  43      -1.877 -13.041  26.733  1.00 26.46   A
ATOM   5282  CB  LYS A  43      -0.644 -13.791  27.243  1.00 26.21   A
ATOM   5283  CG  LYS A  43       0.542 -13.791  26.286  1.00 26.04   A
ATOM   5284  CD  LYS A  43       1.639 -14.723  26.785  1.00 25.92   A
ATOM   5285  CE  LYS A  43       2.864 -14.705  25.878  1.00 26.04   A
ATOM   5286  NZ  LYS A  43       3.565 -13.389  25.888  1.00 25.88   A
ATOM   5287  C   LYS A  43      -2.282 -13.599  25.371  1.00 26.05   A
ATOM   5288  O   LYS A  43      -1.989 -13.002  24.333  1.00 25.81   A
ATOM   5328  N   GLY A  49       0.690 -10.284  22.410  1.00 14.48   A
ATOM   5329  CA  GLY A  49       0.907 -10.936  23.690  1.00 14.19   A
ATOM   5330  C   GLY A  49       1.776 -10.250  24.725  1.00 14.00   A
ATOM   5331  O   GLY A  49       2.495 -10.913  25.474  1.00 13.78   A
ATOM   5332  N   LYS A  50       1.702  -8.928  24.792  1.00 13.70   A
ATOM   5333  CA  LYS A  50       2.505  -8.180  25.749  1.00 13.72   A
ATOM   5334  CB  LYS A  50       3.703  -7.544  25.032  1.00 14.43   A
ATOM   5335  CG  LYS A  50       4.612  -8.550  24.344  1.00 15.06   A
ATOM   5336  CD  LYS A  50       5.479  -9.277  25.357  1.00 15.66   A
ATOM   5337  CE  LYS A  50       6.250 -10.411  24.705  1.00 16.36   A
ATOM   5338  NZ  LYS A  50       6.972  -9.943  23.493  1.00 16.93   A
ATOM   5339  C   LYS A  50       1.689  -7.085  26.416  1.00 13.59   A
ATOM   5340  O   LYS A  50       0.670  -6.644  25.888  1.00 13.10   A
ATOM   5341  N   ILE A  51       2.142  -6.661  27.588  1.00 13.34   A
ATOM   5342  CA  ILE A  51       1.484  -5.588  28.305  1.00 13.51   A
ATOM   5343  CB  ILE A  51       0.720  -6.100  29.544  1.00 14.11   A
ATOM   5344  CG2 ILE A  51      -0.628  -6.656  29.113  1.00 14.02   A
ATOM   5345  CG1 ILE A  51       1.563  -7.135  30.299  1.00 14.40   A
ATOM   5346  CD1 ILE A  51       0.909  -7.639  31.571  1.00 15.17   A
ATOM   5347  C   ILE A  51       2.543  -4.578  28.724  1.00 13.35   A
ATOM   5348  O   ILE A  51       3.731  -4.892  28.769  1.00 13.56   A
ATOM   5349  N   PRO A  52       2.122  -3.355  29.061  1.00 13.08   A
ATOM   5350  CD  PRO A  52       3.043  -2.244  29.369  1.00 13.17   A
ATOM   5351  CA  PRO A  52       0.732  -2.892  29.086  1.00 12.94   A
ATOM   5352  CB  PRO A  52       0.838  -1.561  29.813  1.00 12.82   A
ATOM   5353  CG  PRO A  52       2.132  -1.022  29.259  1.00 13.02   A
ATOM   5354  C   PRO A  52       0.017  -2.716  27.749  1.00 12.81   A
ATOM   5355  O   PRO A  52       0.625  -2.677  26.677  1.00 12.35   A
ATOM   5356  N   ILE A  53      -1.300  -2.611  27.846  1.00 12.88   A
ATOM   5357  CA  ILE A  53      -2.140  -2.343  26.697  1.00 13.33   A
ATOM   5358  CB  ILE A  53      -2.916  -3.585  26.200  1.00 13.90   A
ATOM   5359  CG2 ILE A  53      -1.950  -4.591  25.585  1.00 14.50   A
ATOM   5360  CG1 ILE A  53      -3.736  -4.186  27.339  1.00 14.62   A
ATOM   5361  CD1 ILE A  53      -4.703  -5.260  26.878  1.00 15.26   A
ATOM   5362  C   ILE A  53      -3.132  -1.312  27.213  1.00 13.08   A
ATOM   5363  O   ILE A  53      -3.373  -1.222  28.421  1.00 13.05   A
ATOM   5423  N   HIS A  62      -1.221  -0.970  22.034  1.00 11.06   A
ATOM   5424  CA  HIS A  62      -0.137  -1.598  22.788  1.00 10.38   A
ATOM   5425  CB  HIS A  62       0.135  -3.029  22.287  1.00 10.67   A
ATOM   5426  CG  HIS A  62       0.735  -3.103  20.917  1.00 11.13   A
ATOM   5427  CD2 HIS A  62       1.972  -3.468  20.504  1.00 10.67   A
ATOM   5428  ND1 HIS A  62       0.027  -2.801  19.773  1.00 11.52   A
ATOM   5429  CE1 HIS A  62       0.800  -2.978  18.718  1.00 11.13   A
ATOM   5430  NE2 HIS A  62       1.987  -3.383  19.134  1.00 12.00   A
ATOM   5431  C   HIS A  62       1.136  -0.748  22.707  1.00  9.83   A
ATOM   5432  O   HIS A  62       1.162   0.263  22.007  1.00  9.03   A
ATOM   5433  N   GLN A  63       2.169  -1.173  23.436  1.00  9.33   A
ATOM   5434  CA  GLN A  63       3.456  -0.486  23.515  1.00  8.74   A
ATOM   5435  CB  GLN A  63       4.009  -0.166  22.119  1.00  8.90   A
ATOM   5436  CG  GLN A  63       4.690  -1.358  21.414  1.00  8.45   A
ATOM   5437  CD  GLN A  63       6.016  -1.771  22.058  1.00  9.03   A
ATOM   5438  OE1 GLN A  63       6.588  -1.032  22.858  1.00  7.87   A
ATOM   5439  NE2 GLN A  63       6.513  -2.954  21.691  1.00  8.38   A
ATOM   5440  C   GLN A  63       3.316   0.778  24.362  1.00  8.66   A
ATOM   5441  O   GLN A  63       2.739   1.783  23.938  1.00  7.74   A
ATOM   5442  N   SER A  64       3.855   0.704  25.574  1.00  8.31   A
ATOM   5443  CA  SER A  64       3.766   1.789  26.543  1.00  8.33   A
ATOM   5444  CB  SER A  64       4.595   1.446  27.787  1.00  8.01   A
ATOM   5445  OG  SER A  64       5.978   1.416  27.493  1.00  7.87   A
ATOM   5446  C   SER A  64       4.153   3.172  26.040  1.00  8.36   A
ATOM   5447  O   SER A  64       3.435   4.133  26.290  1.00  8.26   A
ATOM   5448  N   LEU A  65       5.274   3.287  25.333  1.00  8.41   A
ATOM   5449  CA  LEU A  65       5.708   4.601  24.866  1.00  8.36   A
ATOM   5450  CB  LEU A  65       7.197   4.568  24.514  1.00  8.81   A
ATOM   5451  CG  LEU A  65       8.082   4.104  25.687  1.00  9.51   A
ATOM   5452  CD1 LEU A  65       9.553   4.275  25.322  1.00 10.70   A
ATOM   5453  CD2 LEU A  65       7.763   4.915  26.941  1.00  9.59   A
ATOM   5454  C   LEU A  65       4.867   5.102  23.691  1.00  8.52   A
ATOM   5455  O   LEU A  65       4.659   6.308  23.540  1.00  8.38   A
ATOM   5662  N   ASP A  93      13.380   7.412  24.678  1.00  8.42   A
ATOM   5663  CA  ASP A  93      13.975   6.203  24.118  1.00  9.01   A
ATOM   5664  CB  ASP A  93      14.076   6.291  22.584  1.00  9.85   A
ATOM   5665  CG  ASP A  93      12.788   5.838  21.886  1.00 11.05   A
ATOM   5666  OD1 ASP A  93      12.750   5.784  20.630  1.00 11.80   A
ATOM   5667  OD2 ASP A  93      11.809   5.531  22.605  1.00 11.10   A
ATOM   5668  C   ASP A  93      15.344   5.869  24.740  1.00  8.95   A
ATOM   5669  O   ASP A  93      15.656   4.696  24.951  1.00  9.47   A
ATOM   5670  N   THR A  94      16.156   6.881  25.036  1.00  8.96   A
ATOM   5671  CA  THR A  94      17.462   6.638  25.661  1.00  8.70   A
ATOM   5672  CB  THR A  94      18.240   7.965  25.849  1.00  9.08   A
ATOM   5673  OG1 THR A  94      18.678   8.430  24.568  1.00  8.81   A
ATOM   5674  CG2 THR A  94      19.462   7.778  26.759  1.00  8.34   A
ATOM   5675  C   THR A  94      17.264   5.948  27.017  1.00  9.09   A
ATOM   5676  O   THR A  94      17.967   4.987  27.347  1.00  8.99   A
ATOM   5677  N   LEU A  95      16.302   6.442  27.792  1.00  8.65   A
ATOM   5678  CA  LEU A  95      15.996   5.867  29.094  1.00  9.14   A
ATOM   5679  CB  LEU A  95      14.965   6.725  29.838  1.00  9.16   A
ATOM   5680  CG  LEU A  95      15.454   8.091  30.320  1.00  9.32   A
ATOM   5681  CD1 LEU A  95      14.308   8.874  30.967  1.00  9.37   A
ATOM   5682  CD2 LEU A  95      16.580   7.876  31.328  1.00  9.77   A
ATOM   5683  C   LEU A  95      15.462   4.452  28.934  1.00  9.18   A
ATOM   5684  O   LEU A  95      15.891   3.539  29.634  1.00  8.68   A
ATOM   5685  N   ASP A  96      14.529   4.272  28.003  1.00  9.39   A
ATOM   5686  CA  ASP A  96      13.950   2.960  27.759  1.00  9.93   A
ATOM   5687  CB  ASP A  96      12.878   3.058  26.668  1.00 11.27   A
ATOM   5688  CG  ASP A  96      12.035   1.796  26.564  1.00 12.51   A
ATOM   5689  OD1 ASP A  96      11.700   1.220  27.616  1.00 14.48   A
ATOM   5690  OD2 ASP A  96      11.698   1.382  25.444  1.00 13.59   A
ATOM   5691  C   ASP A  96      15.051   1.981  27.354  1.00  9.66   A
ATOM   5692  O   ASP A  96      15.094   0.854  27.845  1.00  9.47   A
ATOM   5693  N   ASP A  97      15.951   2.419  26.476  1.00  9.43   A
ATOM   5694  CA  ASP A  97      17.054   1.567  26.034  1.00  9.98   A
ATOM   5695  CB  ASP A  97      18.033   2.334  25.134  1.00  9.49   A
ATOM   5696  CG  ASP A  97      17.466   2.650  23.760  1.00 10.73   A
ATOM   5697  OD1 ASP A  97      18.142   3.390  23.013  1.00 10.05   A
ATOM   5698  OD2 ASP A  97      16.365   2.164  23.425  1.00 10.69   A
ATOM   5699  C   ASP A  97      17.845   1.038  27.230  1.00 10.11   A
ATOM   5700  O   ASP A  97      18.159  -0.150  27.296  1.00 10.03   A
ATOM   5701  N   PHE A  98      18.185   1.923  28.164  1.00 10.63   A
ATOM   5702  CA  PHE A  98      18.965   1.507  29.325  1.00 11.09   A
ATOM   5703  CB  PHE A  98      19.440   2.717  30.134  1.00 11.78   A
ATOM   5704  CG  PHE A  98      20.383   2.358  31.255  1.00 12.44   A
ATOM   5705  CD1 PHE A  98      21.628   1.793  30.983  1.00 12.99   A
ATOM   5706  CD2 PHE A  98      20.016   2.555  32.579  1.00 12.82   A
ATOM   5707  CE1 PHE A  98      22.494   1.425  32.022  1.00 13.35   A
ATOM   5708  CE2 PHE A  98      20.869   2.193  33.623  1.00 13.21   A
ATOM   5709  CZ  PHE A  98      22.109   1.627  33.343  1.00 13.21   A
ATOM   5710  C   PHE A  98      18.181   0.565  30.231  1.00 11.33   A
ATOM   5711  O   PHE A  98      18.683  -0.494  30.616  1.00 11.57   A
ATOM   5712  N   MET A  99      16.951   0.944  30.568  1.00 11.37   A
ATOM   5713  CA  MET A  99      16.125   0.113  31.429  1.00 12.06   A
ATOM   5714  CB  MET A  99      14.782   0.796  31.715  1.00 12.55   A
ATOM   5715  CG  MET A  99      14.894   2.142  32.413  1.00 13.10   A
ATOM   5716  SD  MET A  99      15.806   2.070  33.972  1.00 14.07   A
ATOM   5717  CE  MET A  99      14.630   1.211  35.020  1.00 14.27   A
ATOM   5718  C   MET A  99      15.877  -1.260  30.812  1.00 12.60   A
ATOM   5719  O   MET A  99      15.754  -2.253  31.528  1.00 12.65   A
ATOM   5720  N   SER A 100      15.807  -1.316  29.484  1.00 12.96   A
ATOM   5721  CA  SER A 100      15.567  -2.576  28.784  1.00 13.81   A
ATOM   5722  CB  SER A 100      15.121  -2.302  27.344  1.00 14.23   A
ATOM   5723  OG  SER A 100      13.828  -1.725  27.328  1.00 15.92   A
ATOM   5724  C   SER A 100      16.789  -3.494  28.785  1.00 14.13   A
ATOM   5725  O   SER A 100      16.669  -4.686  28.507  1.00 14.04   A
ATOM   5726  N   CYS A 101      17.959  -2.938  29.097  1.00 14.67   A
ATOM   5727  CA  CYS A 101      19.187  -3.723  29.152  1.00 15.64   A
ATOM   5728  CB  CYS A 101      20.415  -2.812  29.235  1.00 16.10   A
ATOM   5729  SG  CYS A 101      20.893  -2.013  27.701  1.00 17.92   A
ATOM   5730  C   CYS A 101      19.197  -4.670  30.350  1.00 15.85   A
ATOM   5731  O   CYS A 101      19.926  -5.662  30.350  1.00 15.88   A
ATOM   5732  N   PHE A 102      18.404  -4.361  31.373  1.00 15.73   A
ATOM   5733  CA  PHE A 102      18.343  -5.214  32.562  1.00 15.76   A
ATOM   5734  CB  PHE A 102      17.748  -4.462  33.754  1.00 15.27   A
ATOM   5735  CG  PHE A 102      18.613  -3.348  34.258  1.00 15.10   A
ATOM   5736  CD1 PHE A 102      18.642  -2.125  33.600  1.00 14.99   A
ATOM   5737  CD2 PHE A 102      19.414  -3.527  35.380  1.00 14.73   A
ATOM   5738  CE1 PHE A 102      19.457  -1.092  34.050  1.00 15.09   A
ATOM   5739  CE2 PHE A 102      20.237  -2.500  35.841  1.00 14.94   A
ATOM   5740  CZ  PHE A 102      20.256  -1.280  35.174  1.00 14.83   A
ATOM   5741  C   PHE A 102      17.505  -6.455  32.295  1.00 16.19   A
ATOM   5742  O   PHE A 102      16.415  -6.366  31.728  1.00 15.63   A
ATOM   5743  N   PRO A 103      18.009  -7.632  32.699  1.00 16.76   A
ATOM   5744  CD  PRO A 103      19.356  -7.845  33.260  1.00 17.02   A
ATOM   5745  CA  PRO A 103      17.319  -8.914  32.512  1.00 17.47   A
ATOM   5746  CB  PRO A 103      18.456  -9.923  32.609  1.00 17.20   A
ATOM   5747  CG  PRO A 103      19.315  -9.315  33.668  1.00 17.07   A
ATOM   5748  C   PRO A 103      16.246  -9.145  33.577  1.00 18.16   A
ATOM   5749  O   PRO A 103      16.363 -10.043  34.418  1.00 18.22   A
ATOM   5750  N   TRP A 104      15.197  -8.331  33.525  1.00 18.78   A
ATOM   5751  CA  TRP A 104      14.099  -8.414  34.482  1.00 19.84   A
ATOM   5752  CB  TRP A 104      13.017  -7.381  34.141  1.00 18.95   A
ATOM   5753  CG  TRP A 104      13.517  -5.971  34.076  1.00 18.24   A
ATOM   5754  CD2 TRP A 104      13.896  -5.144  35.182  1.00 17.79   A
ATOM   5755  CE2 TRP A 104      14.321  -3.906  34.652  1.00 17.69   A
ATOM   5756  CE3 TRP A 104      13.921  -5.329  36.572  1.00 17.54   A
ATOM   5757  CD1 TRP A 104      13.720  -5.224  32.951  1.00 17.72   A
ATOM   5758  NE1 TRP A 104      14.201  -3.981  33.289  1.00 17.64   A
ATOM   5759  CZ2 TRP A 104      14.765  -2.856  35.463  1.00 17.79   A
ATOM   5760  CZ3 TRP A 104      14.363  -4.282  37.379  1.00 17.58   A
ATOM   5761  CH2 TRP A 104      14.778  -3.064  36.820  1.00 17.48   A
ATOM   5762  C   TRP A 104      13.449  -9.790  34.572  1.00 20.99   A
ATOM   5763  O   TRP A 104      13.031 -10.207  35.650  1.00 21.33   A
ATOM   5764  N   ALA A 105      13.359 -10.493  33.447  1.00 22.46   A
ATOM   5765  CA  ALA A 105      12.720 -11.807  33.434  1.00 23.88   A
ATOM   5766  CB  ALA A 105      11.878 -11.961  32.169  1.00 23.69   A
ATOM   5767  C   ALA A 105      13.685 -12.982  33.565  1.00 24.90   A
ATOM   5768  O   ALA A 105      13.262 -14.136  33.576  1.00 25.13   A
ATOM   5769  N   GLU A 106      14.976 -12.686  33.675  1.00 26.10   A
ATOM   5770  CA  GLU A 106      15.996 -13.721  33.803  1.00 27.43   A
ATOM   5771  CB  GLU A 106      17.388 -13.083  33.790  1.00 27.61   A
ATOM   5772  CG  GLU A 106      18.550 -14.065  33.842  1.00 28.16   A
ATOM   5773  CD  GLU A 106      18.455 -15.144  32.775  1.00 28.35   A
ATOM   5774  OE1 GLU A 106      17.850 -16.200  33.045  1.00 28.68   A
ATOM   5775  OE2 GLU A 106      18.973 -14.931  31.662  1.00 28.90   A
ATOM   5776  C   GLU A 106      15.823 -14.543  35.077  1.00 28.31   A
ATOM   5777  O   GLU A 106      15.898 -14.010  36.185  1.00 28.41   A
ATOM   5778  N   LYS A 107      15.591 -15.842  34.908  1.00 29.48   A
ATOM   5779  CA  LYS A 107      15.420 -16.754  36.038  1.00 30.63   A
ATOM   5780  CB  LYS A 107      14.695 -18.028  35.594  1.00 31.06   A
ATOM   5781  CG  LYS A 107      13.187 -18.016  35.779  1.00 31.97   A
ATOM   5782  CD  LYS A 107      12.495 -17.030  34.864  1.00 32.92   A
ATOM   5783  CE  LYS A 107      10.983 -17.201  34.945  1.00 33.65   A
ATOM   5784  NZ  LYS A 107      10.485 -17.067  36.346  1.00 34.05   A
ATOM   5785  C   LYS A 107      16.775 -17.133  36.630  1.00 31.06   A
ATOM   5786  O   LYS A 107      16.874 -17.465  37.810  1.00 31.19   A
ATOM   5787  N   LYS A 108      17.810 -17.094  35.796  1.00 31.69   A
ATOM   5788  CA  LYS A 108      19.163 -17.421  36.231  1.00 32.35   A
ATOM   5789  CB  LYS A 108      20.082 -17.563  35.017  1.00 32.50   A
ATOM   5790  CG  LYS A 108      19.634 -18.632  34.033  1.00 32.81   A
ATOM   5791  CD  LYS A 108      20.454 -18.602  32.757  1.00 33.35   A
ATOM   5792  CE  LYS A 108      19.977 -19.664  31.777  1.00 33.34   A
ATOM   5793  NZ  LYS A 108      20.660 -19.552  30.454  1.00 33.69   A
ATOM   5794  C   LYS A 108      19.668 -16.305  37.143  1.00 32.68   A
ATOM   5795  O   LYS A 108      20.180 -15.288  36.675  1.00 32.69   A
ATOM   5796  N   GLN A 109      19.518 -16.510  38.447  1.00 33.05   A
ATOM   5797  CA  GLN A 109      19.923 -15.529  39.443  1.00 33.40   A
ATOM   5798  CB  GLN A 109      19.719 -16.101  40.846  1.00 34.05   A
ATOM   5799  CG  GLN A 109      18.943 -15.175  41.763  1.00 34.95   A
ATOM   5800  CD  GLN A 109      17.561 -14.854  41.223  1.00 35.27   A
ATOM   5801  OE1 GLN A 109      16.934 -13.878  41.633  1.00 35.73   A
ATOM   5802  NE2 GLN A 109      17.077 -15.682  40.301  1.00 35.62   A
ATOM   5803  C   GLN A 109      21.360 -15.042  39.293  1.00 33.21   A
ATOM   5804  O   GLN A 109      21.619 -13.842  39.374  1.00 33.28   A
ATOM   5805  N   ASP A 110      22.290 -15.966  39.078  1.00 32.78   A
ATOM   5806  CA  ASP A 110      23.692 -15.597  38.927  1.00 32.30   A
ATOM   5807  CB  ASP A 110      24.569 -16.852  38.841  1.00 32.93   A
ATOM   5808  CG  ASP A 110      24.303 -17.670  37.592  1.00 33.42   A
ATOM   5809  OD1 ASP A 110      23.137 -18.065  37.371  1.00 33.92   A
ATOM   5810  OD2 ASP A 110      25.263 -17.921  36.832  1.00 33.95   A
ATOM   5811  C   ASP A 110      23.891 -14.734  37.684  1.00 31.55   A
ATOM   5812  O   ASP A 110      24.641 -13.759  37.708  1.00 31.47   A
ATOM   5813  N   VAL A 111      23.211 -15.096  36.600  1.00 30.50   A
ATOM   5814  CA  VAL A 111      23.310 -14.352  35.350  1.00 29.55   A
ATOM   5815  CB  VAL A 111      22.661 -15.130  34.188  1.00 29.61   A
ATOM   5816  CG1 VAL A 111      22.743 -14.322  32.907  1.00 29.78   A
ATOM   5817  CG2 VAL A 111      23.353 -16.469  34.017  1.00 29.84   A
ATOM   5818  C   VAL A 111      22.613 -13.000  35.485  1.00 28.61   A
ATOM   5819  O   VAL A 111      23.069 -11.995  34.939  1.00 28.38   A
ATOM   5820  N   LYS A 112      21.509 -12.986  36.224  1.00 27.55   A
ATOM   5821  CA  LYS A 112      20.746 -11.763  36.435  1.00 26.48   A
ATOM   5822  CB  LYS A 112      19.414 -12.083  37.117  1.00 26.47   A
ATOM   5823  CG  LYS A 112      18.452 -10.907  37.177  1.00 25.94   A
ATOM   5824  CD  LYS A 112      17.173 -11.278  37.904  1.00 26.05   A
ATOM   5825  CE  LYS A 112      16.181 -10.125  37.906  1.00 25.77   A
ATOM   5826  NZ  LYS A 112      14.951 -10.457  38.676  1.00 25.64   A
ATOM   5827  C   LYS A 112      21.523 -10.765  37.287  1.00 26.12   A
ATOM   5828  O   LYS A 112      21.631  -9.589  36.941  1.00 25.60   A
ATOM   5829  N   GLU A 113      22.062 -11.243  38.404  1.00 25.24   A
ATOM   5830  CA  GLU A 113      22.818 -10.393  39.314  1.00 25.10   A
ATOM   5831  CB  GLU A 113      23.128 -11.159  40.605  1.00 25.39   A
ATOM   5832  CG  GLU A 113      23.862 -10.347  41.669  1.00 25.63   A
ATOM   5833  CD  GLU A 113      23.026  -9.213  42.248  1.00 25.83   A
ATOM   5834  OE1 GLU A 113      23.522  -8.525  43.170  1.00 25.56   A
ATOM   5835  OE2 GLU A 113      21.880  -9.008  41.786  1.00 25.58   A
ATOM   5836  C   GLU A 113      24.113  -9.891  38.676  1.00 24.67   A
ATOM   5837  O   GLU A 113      24.578  -8.791  38.975  1.00 24.33   A
ATOM   5838  N   GLN A 114      24.689 -10.702  37.796  1.00 24.42   A
ATOM   5839  CA  GLN A 114      25.926 -10.341  37.116  1.00 24.24   A
ATOM   5840  CB  GLN A 114      26.438 -11.538  36.308  1.00 24.91   A
ATOM   5841  CG  GLN A 114      27.868 -11.417  35.789  1.00 25.97   A
ATOM   5842  CD  GLN A 114      28.030 -10.372  34.700  1.00 26.74   A
ATOM   5843  OE1 GLN A 114      27.278 -10.353  33.723  1.00 26.88   A
ATOM   5844  NE2 GLN A 114      29.026  -9.502  34.856  1.00 27.12   A
ATOM   5845  C   GLN A 114      25.685  -9.148  36.193  1.00 23.68   A
ATOM   5846  O   GLN A 114      26.465  -8.194  36.180  1.00 23.45   A
ATOM   5847  N   MET A 115      24.598  -9.196  35.429  1.00 22.98   A
ATOM   5848  CA  MET A 115      24.284  -8.113  34.503  1.00 22.57   A
ATOM   5849  CB  MET A 115      23.229  -8.566  33.489  1.00 24.00   A
ATOM   5850  CG  MET A 115      22.980  -7.560  32.371  1.00 25.61   A
ATOM   5851  SD  MET A 115      24.507  -6.939  31.592  1.00 28.29   A
ATOM   5852  CE  MET A 115      24.966  -8.333  30.583  1.00 27.44   A
ATOM   5853  C   MET A 115      23.815  -6.855  35.228  1.00 21.47   A
ATOM   5854  O   MET A 115      24.191  -5.747  34.851  1.00 20.89   A
ATOM   5855  N   PHE A 116      22.998  -7.025  36.265  1.00 20.55   A
ATOM   5856  CA  PHE A 116      22.515  -5.882  37.033  1.00 19.83   A
ATOM   5857  CB  PHE A 116      21.626  -6.334  38.195  1.00 19.24   A
ATOM   5858  CG  PHE A 116      20.154  -6.260  37.901  1.00 18.22   A
ATOM   5859  CD1 PHE A 116      19.554  -7.163  37.030  1.00 17.96   A
ATOM   5860  CD2 PHE A 116      19.368  -5.284  38.501  1.00 17.91   A
ATOM   5861  CE1 PHE A 116      18.186  -7.096  36.761  1.00 17.74   A
ATOM   5862  CE2 PHE A 116      18.001  -5.205  38.241  1.00 17.75   A
ATOM   5863  CZ  PHE A 116      17.409  -6.114  37.368  1.00 17.62   A
ATOM   5864  C   PHE A 116      23.701  -5.110  37.593  1.00 20.07   A
ATOM   5865  O   PHE A 116      23.789  -3.891  37.450  1.00 19.59   A
ATOM   6152  N   TYR A 152       9.211  10.332  32.716  1.00  8.70   A
ATOM   6153  CA  TYR A 152       9.897   9.070  32.511  1.00  8.91   A
ATOM   6154  CB  TYR A 152      10.120   8.824  31.021  1.00  9.31   A
ATOM   6155  CG  TYR A 152      10.158   7.355  30.660  1.00 10.11   A
ATOM   6156  CD1 TYR A 152       9.197   6.466  31.160  1.00 10.35   A
ATOM   6157  CE1 TYR A 152       9.215   5.109  30.811  1.00 10.49   A
ATOM   6158  CD2 TYR A 152      11.137   6.854  29.804  1.00 10.28   A
ATOM   6159  CE2 TYR A 152      11.160   5.505  29.448  1.00 10.37   A
ATOM   6160  CZ  TYR A 152      10.206   4.642  29.950  1.00 10.60   A
ATOM   6161  OH  TYR A 152      10.245   3.314  29.587  1.00 10.57   A
ATOM   6162  C   TYR A 152      11.211   9.033  33.272  1.00  9.20   A
ATOM   6163  O   TYR A 152      11.622   7.982  33.759  1.00  9.19   A
ATOM   6164  N   TRP A 153      11.869  10.180  33.386  1.00  9.22   A
ATOM   6165  CA  TRP A 153      13.113  10.224  34.135  1.00  9.64   A
ATOM   6166  CB  TRP A 153      13.752  11.613  34.067  1.00 10.03   A
ATOM   6167  CG  TRP A 153      14.748  11.836  35.157  1.00 10.79   A
ATOM   6168  CD2 TRP A 153      15.900  11.033  35.441  1.00 11.30   A
ATOM   6169  CE2 TRP A 153      16.521  11.583  36.585  1.00 11.43   A
ATOM   6170  CE3 TRP A 153      16.467   9.899  34.841  1.00 11.63   A
ATOM   6171  CD1 TRP A 153      14.717  12.816  36.111  1.00 10.88   A
ATOM   6172  NE1 TRP A 153      15.780  12.669  36.974  1.00 11.27   A
ATOM   6173  CZ2 TRP A 153      17.682  11.040  37.142  1.00 11.66   A
ATOM   6174  CZ3 TRP A 153      17.629   9.354  35.398  1.00 12.00   A
ATOM   6175  CH2 TRP A 153      18.221   9.931  36.539  1.00 11.19   A
ATOM   6176  C   TRP A 153      12.836   9.867  35.593  1.00  9.64   A
ATOM   6177  O   TRP A 153      13.518   9.022  36.175  1.00  9.85   A
ATOM   6178  N   GLU A 154      11.827  10.504  36.177  1.00  9.88   A
ATOM   6179  CA  GLU A 154      11.491  10.260  37.570  1.00  9.73   A
ATOM   6180  CB  GLU A 154      10.379  11.222  38.007  1.00 10.24   A
ATOM   6181  CG  GLU A 154      10.187  11.310  39.509  1.00 11.28   A
ATOM   6182  CD  GLU A 154       9.315  10.199  40.035  1.00 11.50   A
ATOM   6183  OE1 GLU A 154       9.291   9.987  41.267  1.00 12.33   A
ATOM   6184  OE2 GLU A 154       8.645   9.543  39.207  1.00 12.17   A
ATOM   6185  C   GLU A 154      11.081   8.802  37.785  1.00  9.53   A
ATOM   6186  O   GLU A 154      11.468   8.180  38.776  1.00  9.12   A
ATOM   6187  N   ILE A 155      10.320   8.257  36.837  1.00  8.98   A
ATOM   6188  CA  ILE A 155       9.870   6.875  36.904  1.00  8.87   A
ATOM   6189  CB  ILE A 155       8.810   6.599  35.815  1.00  8.72   A
ATOM   6190  CG2 ILE A 155       8.550   5.097  35.683  1.00  9.06   A
ATOM   6191  CG1 ILE A 155       7.524   7.354  36.173  1.00  8.74   A
ATOM   6192  CD1 ILE A 155       6.467   7.383  35.064  1.00  8.73   A
ATOM   6193  C   ILE A 155      11.035   5.888  36.782  1.00  9.35   A
ATOM   6194  O   ILE A 155      11.180   4.986  37.609  1.00  9.36   A
ATOM   6195  N   CYS A 156      11.873   6.063  35.766  1.00  9.31   A
ATOM   6196  CA  CYS A 156      13.012   5.175  35.589  1.00 10.15   A
ATOM   6197  CB  CYS A 156      13.734   5.471  34.269  1.00 10.37   A
ATOM   6198  SG  CYS A 156      12.770   5.037  32.774  1.00 11.81   A
ATOM   6199  C   CYS A 156      14.008   5.280  36.741  1.00 10.50   A
ATOM   6200  O   CYS A 156      14.480   4.262  37.247  1.00 10.92   A
ATOM   6201  N   SER A 157      14.325   6.499  37.163  1.00 10.75   A
ATOM   6202  CA  SER A 157      15.291   6.680  38.246  1.00 10.88   A
ATOM   6203  CB  SER A 157      15.633   8.167  38.431  1.00 11.09   A
ATOM   6204  OG  SER A 157      14.501   8.948  38.749  1.00 11.29   A
ATOM   6205  C   SER A 157      14.813   6.073  39.565  1.00 11.31   A
ATOM   6206  O   SER A 157      15.618   5.576  40.357  1.00 11.45   A
ATOM   6207  N   THR A 158      13.506   6.113  39.799  1.00 11.14   A
ATOM   6208  CA  THR A 158      12.932   5.538  41.008  1.00 11.46   A
ATOM   6209  CB  THR A 158      11.396   5.654  40.996  1.00 10.96   A
ATOM   6210  OG1 THR A 158      11.028   7.026  41.168  1.00 11.35   A
ATOM   6211  CG2 THR A 158      10.775   4.806  42.114  1.00 10.93   A
ATOM   6212  C   THR A 158      13.310   4.059  41.104  1.00 11.75   A
ATOM   6213  O   THR A 158      13.749   3.588  42.151  1.00 11.75   A
ATOM   6214  N   THR A 159      13.139   3.328  40.006  1.00 11.91   A
ATOM   6215  CA  THR A 159      13.470   1.910  40.002  1.00 12.52   A
ATOM   6216  CB  THR A 159      12.884   1.205  38.760  1.00 12.63   A
ATOM   6217  OG1 THR A 159      11.455   1.252  38.832  1.00 12.91   A
ATOM   6218  CG2 THR A 159      13.327  -0.263  38.705  1.00 12.73   A
ATOM   6219  C   THR A 159      14.978   1.666  40.084  1.00 12.45   A
ATOM   6220  O   THR A 159      15.424   0.723  40.739  1.00 12.48   A
ATOM   6221  N   LEU A 160      15.767   2.516  39.436  1.00 12.52   A
ATOM   6222  CA  LEU A 160      17.215   2.356  39.490  1.00 12.72   A
ATOM   6223  CB  LEU A 160      17.908   3.355  38.555  1.00 12.33   A
ATOM   6224  CG  LEU A 160      17.690   3.148  37.047  1.00 13.04   A
ATOM   6225  CD1 LEU A 160      18.367   4.267  36.268  1.00 12.38   A
ATOM   6226  CD2 LEU A 160      18.247   1.793  36.629  1.00 12.53   A
ATOM   6227  C   LEU A 160      17.716   2.563  40.922  1.00 12.87   A
ATOM   6228  O   LEU A 160      18.607   1.850  41.380  1.00 13.07   A
ATOM   6229  N   LEU A 161      17.130   3.528  41.628  1.00 13.22   A
ATOM   6230  CA  LEU A 161      17.530   3.828  43.000  1.00 13.77   A
ATOM   6231  CB  LEU A 161      16.833   5.102  43.490  1.00 13.77   A
ATOM   6232  CG  LEU A 161      17.314   6.417  42.863  1.00 13.80   A
ATOM   6233  CD1 LEU A 161      16.371   7.552  43.241  1.00 13.46   A
ATOM   6234  CD2 LEU A 161      18.736   6.723  43.329  1.00 13.49   A
ATOM   6235  C   LEU A 161      17.252   2.684  43.967  1.00 14.34   A
ATOM   6236  O   LEU A 161      17.839   2.619  45.050  1.00 14.37   A
ATOM   6237  N   VAL A 162      16.350   1.792  43.578  1.00 14.42   A
ATOM   6238  CA  VAL A 162      16.019   0.639  44.404  1.00 15.39   A
ATOM   6239  CB  VAL A 162      14.826  -0.146  43.813  1.00 15.43   A
ATOM   6240  CG1 VAL A 162      14.643  -1.467  44.565  1.00 15.56   A
ATOM   6241  CG2 VAL A 162      13.559   0.698  43.910  1.00 15.37   A
ATOM   6242  C   VAL A 162      17.232  -0.289  44.493  1.00 16.01   A
ATOM   6243  O   VAL A 162      17.490  -0.899  45.535  1.00 16.21   A
ATOM   6244  N   PHE A 163      17.982  -0.381  43.399  1.00 16.34   A
ATOM   6245  CA  PHE A 163      19.160  -1.237  43.354  1.00 17.20   A
ATOM   6246  CB  PHE A 163      19.218  -1.999  42.026  1.00 17.31   A
ATOM   6247  CG  PHE A 163      17.979  -2.791  41.729  1.00 18.00   A
ATOM   6248  CD1 PHE A 163      16.865  -2.177  41.173  1.00 18.03   A
ATOM   6249  CD2 PHE A 163      17.917  -4.149  42.029  1.00 18.06   A
ATOM   6250  CE1 PHE A 163      15.704  -2.900  40.922  1.00 18.23   A
ATOM   6251  CE2 PHE A 163      16.757  -4.884  41.782  1.00 18.01   A
ATOM   6252  CZ  PHE A 163      15.649  -4.258  41.227  1.00 18.18   A
ATOM   6253  C   PHE A 163      20.470  -0.482  43.553  1.00 17.48   A
ATOM   6254  O   PHE A 163      21.473  -1.078  43.937  1.00 17.90   A
ATOM   6528  N   THR A 197       4.591  -0.941  45.453  1.00 17.89   A
ATOM   6529  CA  THR A 197       5.221  -2.157  44.953  1.00 17.58   A
ATOM   6530  CB  THR A 197       4.623  -2.571  43.592  1.00 17.29   A
ATOM   6531  OG1 THR A 197       4.796  -1.501  42.652  1.00 17.06   A
ATOM   6532  CG2 THR A 197       3.135  -2.881  43.732  1.00 17.03   A
ATOM   6533  C   THR A 197       6.712  -1.903  44.780  1.00 17.29   A
ATOM   6534  O   THR A 197       7.139  -0.757  44.661  1.00 17.19   A
ATOM   6535  N   LYS A 198       7.507  -2.967  44.775  1.00 17.12   A
ATOM   6536  CA  LYS A 198       8.948  -2.813  44.620  1.00 17.28   A
ATOM   6537  CB  LYS A 198       9.647  -4.168  44.727  1.00 17.40   A
ATOM   6538  CG  LYS A 198      11.159  -4.088  44.582  1.00 17.55   A
ATOM   6539  CD  LYS A 198      11.792  -5.459  44.688  1.00 17.80   A
ATOM   6540  CE  LYS A 198      13.304  -5.355  44.747  1.00 17.96   A
ATOM   6541  NZ  LYS A 198      13.944  -6.692  44.918  1.00 19.01   A
ATOM   6542  C   LYS A 198       9.292  -2.172  43.280  1.00 17.06   A
ATOM   6543  O   LYS A 198       9.996  -1.163  43.225  1.00 16.95   A
ATOM   6544  N   LEU A 199       8.783  -2.762  42.205  1.00 17.25   A
ATOM   6545  CA  LEU A 199       9.049  -2.271  40.860  1.00 17.51   A
ATOM   6546  CB  LEU A 199       9.557  -3.420  39.987  1.00 18.10   A
ATOM   6547  CG  LEU A 199      10.722  -4.239  40.550  1.00 18.31   A
ATOM   6548  CD1 LEU A 199      11.046  -5.365  39.591  1.00 18.98   A
ATOM   6549  CD2 LEU A 199      11.941  -3.350  40.768  1.00 18.60   A
ATOM   6550  C   LEU A 199       7.804  -1.655  40.228  1.00 17.54   A
ATOM   6551  O   LEU A 199       6.789  -1.503  40.943  1.00 17.46   A
ATOM   6552  OXT LEU A 199       7.864  -1.331  39.025  1.00 17.38   A
ATOM   6613  N1  GSH H 200       8.267  -2.783  25.084  1.00 18.14   H
ATOM   6614  CA1 GSH H 200       6.892  -3.012  25.512  1.00 18.05   H
ATOM   6615  C1  GSH H 200       6.253  -1.716  26.049  1.00 17.74   H
ATOM   6616  O11 GSH H 200       6.974  -0.743  26.300  1.00 17.76   H
ATOM   6617  O12 GSH H 200       4.957  -1.770  26.305  1.00 17.69   H
ATOM   6618  CB1 GSH H 200       6.915  -4.033  26.658  1.00 18.51   H
ATOM   6619  CG1 GSH H 200       6.911  -5.492  26.184  1.00 19.29   H
ATOM   6620  CD1 GSH H 200       7.126  -6.355  27.445  1.00 18.72   H
ATOM   6621  OE1 GSH H 200       8.184  -6.947  27.593  1.00 19.64   H
ATOM   6622  N2  GSH H 200       6.110  -6.407  28.322  1.00 18.69   H
ATOM   6623  CA2 GSH H 200       6.216  -7.299  29.489  1.00 18.57   H
ATOM   6624  C2  GSH H 200       5.273  -8.489  29.291  1.00 19.14   H
ATOM   6625  O2  GSH H 200       4.151  -8.358  28.784  1.00 19.07   H
ATOM   6626  CB2 GSH H 200       5.800  -6.596  30.799  1.00 18.29   H
ATOM   6627  SG2 GSH H 200       7.094  -5.503  31.467  1.00 17.57   H
ATOM   6628  N3  GSH H 200       5.713  -9.677  29.767  1.00 19.66   H
ATOM   6629  CA3 GSH H 200       4.866 -10.887  29.805  1.00 20.05   H
ATOM   6630  C3  GSH H 200       5.256 -11.824  28.677  1.00 20.59   H
ATOM   6631  O31 GSH H 200       4.643 -12.911  28.623  1.00 20.61   H
ATOM   6632  O32 GSH H 200       6.164 -11.461  27.881  1.00 20.69   H
ATOM   6633 CA+2 CA2 M 900      12.319   1.399  22.690  1.00 23.39   M
ATOM   6700  OH2 WAT S  68      14.121   2.911  22.047  1.00 14.43   S
ATOM   6701  OH2 WAT S  69      10.382   0.015  22.374  1.00 17.83   S
ATOM   6702  OH2 WAT S  70       6.835   1.587  23.510  1.00 10.00   S
ATOM   6703  OH2 WAT S  71       9.084   0.596  24.637  1.00 20.95   S
ATOM   6704  OH2 WAT S  72       7.464   2.364  29.866  1.00 18.58   S
ATOM   6705  OH2 WAT S  73       6.627   3.292  32.747  1.00 10.51   S
ATOM   6706  OH2 WAT S  74      10.027  -0.425  37.514  1.00 16.92   S
ATOM   6707  OH2 WAT S  75       8.932   1.748  36.205  1.00 14.34   S
ATOM   6708  OH2 WAT S  76       9.214   3.513  38.532  1.00 18.39   S
ATOM   6736  OH2 WAT S 106       8.886  -7.534  20.205  1.00 13.51   S
ATOM   6737  OH2 WAT S 107       3.110  -4.937  22.720  1.00 12.05   S
ATOM   6738  OH2 WAT S 108       0.868  -6.588  23.134  1.00 10.94   S
ATOM   6739  OH2 WAT S 109       5.765  -8.770  20.668  1.00 22.48   S
ATOM   6740  OH2 WAT S 110       7.826  -6.141  22.398  1.00 11.14   S
ATOM   6741  OH2 WAT S 111       5.382  -6.173  21.467  1.00 10.04   S
ATOM   6742  OH2 WAT S 112      13.216  -1.032  21.636  1.00 18.10   S
ATOM   6744  OH2 WAT S 114      17.856  -1.808  25.058  1.00 20.41   S
ATOM   6760  OH2 WAT S 130       3.197 -14.232  20.833  1.00 51.90   S
ATOM   6991  OH2 WAT S 374       1.473   2.207  40.356  1.00 10.67   S
ATOM   6992  OH2 WAT S 375       4.951   1.805  44.037  1.00 15.41   S
ATOM   7014  OH2 WAT S 399      -1.260  -6.795  21.531  1.00 15.82   S
ATOM   7015  OH2 WAT S 400      -2.774  -4.748  20.376  1.00 27.99   S
ATOM   7018  OH2 WAT S 403       2.577   0.177  41.980  1.00 13.62   S
ATOM   7019  OH2 WAT S 404       0.564  -8.538  39.036  1.00 23.05   S
ATOM   7020  OH2 WAT S 405       8.238  -9.999  31.265  1.00 29.66   S
ATOM   7040  OH2 WAT S 426      11.203   0.001  32.951  1.00 36.44   S
ATOM   7041  OH2 WAT S 428      15.066 -17.180  32.416  1.00 31.37   S
ATOM   7042  OH2 WAT S 429      10.965  -7.436  30.782  1.00 46.48   S
ATOM   7053  OH2 WAT S 443      -2.454  -1.326  35.257  1.00  9.90   S
ATOM   7075  OH2 WAT S 476       9.258 -15.961  22.392  1.00 35.74   S
ATOM   7079  OH2 WAT S 484      18.667  -6.199  25.509  1.00 51.86   S
ATOM   7181  OH2 WAT S 609      14.259   0.633  24.144  1.00 13.45   S
ATOM   7185  OH2 WAT S 616       6.184  -5.556  45.296  1.00 23.90   S
ATOM   7186  OH2 WAT S 617       8.234  -7.048  46.247  1.00 26.45   S
ATOM   7201  OH2 WAT S 637       8.943  -7.562  24.594  1.00 21.20   S
ATOM   7202  OH2 WAT S 638      10.718  -9.017  21.394  1.00 20.69   S
ATOM   7203  OH2 WAT S 639       6.772 -12.758  20.621  1.00 31.01   S
ATOM   7204  OH2 WAT S 640       4.298 -12.631  22.679  1.00 44.61   S
ATOM   7205  OH2 WAT S 642      11.438  -5.078  25.419  1.00 41.38   S
ATOM   7215  OH2 WAT S 657       2.956  -3.352  25.272  1.00 13.15   S
ATOM   7232  OH2 WAT S 690      14.369  -9.780  30.964  1.00 44.36   S
ATOM   7233  OH2 WAT S 692      18.178  -7.756  40.325  1.00 19.70   S
ATOM   7235  OH2 WAT S 696       7.112  -5.132  42.047  1.00 21.00   S
ATOM   7237  OH2 WAT S 698       8.595  -7.307  41.589  1.00 30.04   S
ATOM   7238  OH2 WAT S 699      13.321  -7.321  42.140  1.00 27.80   S
ATOM   7240  OH2 WAT S 702      -6.903  -2.845  28.812  1.00 20.55   S
ATOM   7245  OH2 WAT S 707      10.773   3.112  22.561  1.00 18.01   S
ATOM   7249  OH2 WAT S 713      14.133 -12.827  37.720  1.00 37.72   S
ATOM   7257  OH2 WAT S 729       9.660  -4.357  34.020  1.00 40.28   S
ATOM   7260  OH2 WAT S 735      10.625  -2.519  35.392  1.00 46.30   S
ATOM   7291  OH2 WAT S 783       8.130  -9.654  27.367  1.00 21.27   S
ATOM   7318  OH2 WAT S 831       5.332 -11.112  19.145  1.00 24.71   S
ATOM   7333  OH2 WAT S 860      15.591  -0.692  20.940  1.00 38.98   S
ATOM   7334  OH2 WAT S 861      15.057  -5.068  23.204  1.00 45.10   S
ATOM   7336  OH2 WAT S 864      17.064  -8.176  25.940  1.00 41.30   S
ATOM   7368  OH2 WAT S 916       4.717  -6.156  42.468  1.00 32.94   S
ATOM   7371  OH2 WAT S 920      19.610 -12.642  30.175  1.00 31.99   S
ATOM   7386  OH2 WAT S 948      12.372   1.268  20.616  1.00 22.94   S
ATOM   7399  OH2 WAT S 968       7.575 -13.636  26.467  1.00 40.77   S
ATOM   7400  OH2 WAT S 969      13.034 -12.270  21.957  1.00 29.54   S
ATOM   7415  OH2 WAT T   1      13.128  -8.340  38.325  1.00 43.19   T
ATOM   7416  OH2 WAT T   2       9.607  -8.619  44.219  1.00 27.56   T
ATOM   7503  OH2 WAT T  98       3.711  -6.417  45.304  1.00 30.04   T
ATOM   7507  OH2 WAT T 102      -3.417  -7.320  40.850  1.00 33.06   T
ATOM   7602  OH2 WAT T 203      14.604  -1.609  23.500  1.00 40.59   T
ATOM   7612  OH2 WAT T 215       4.850 -13.737  39.498  1.00 42.03   T
ATOM   7613  OH2 WAT T 216       5.093 -14.055  32.065  1.00 39.20   T
ATOM   7616  OH2 WAT T 219      11.030  -2.293  26.081  1.00 37.10   T
ATOM   7619  OH2 WAT T 225       7.449  -9.230  35.544  1.00 45.80   T
ATOM   7620  OH2 WAT T 226      10.479  -7.325  36.925  1.00 40.53   T
ATOM   7632  OH2 WAT T 263      16.989  -4.269  24.857  1.00 37.79   T
ATOM   7633  OH2 WAT T 264      16.818  -0.589  23.119  1.00 33.03   T
ATOM   7634  OH2 WAT T 265      12.877  -2.966  24.468  1.00 44.25   T
ATOM   7637  OH2 WAT T 268      15.829 -10.496  25.604  1.00 39.46   T
ATOM   7638  OH2 WAT T 269      12.401 -18.158  31.715  1.00 28.89   T
ATOM   7669  OH2 WAT T 341       6.084 -13.571  24.399  1.00 44.58   T
ATOM   7670  OH2 WAT T 342      12.132 -14.509  26.051  1.00 36.17   T
ATOM   7723  OH2 WAT T 439      10.138  -4.873  30.054  1.00 32.06   T
【００４８】
【表２】
ヒト由来造血器型ＰＧＤＳマグネシウム型とグルタチオンとの複合体の３次元構造座標
ATOM   4966  N   TYR A   8      24.798  32.294  34.444  1.00 27.67   A
ATOM   4967  CA  TYR A   8      23.375  32.556  34.622  1.00 27.57   A
ATOM   4968  CB  TYR A   8      22.609  31.228  34.679  1.00 26.91   A
ATOM   4969  CG  TYR A   8      21.105  31.363  34.647  1.00 26.02   A
ATOM   4970  CD1 TYR A   8      20.462  31.990  33.580  1.00 25.80   A
ATOM   4971  CE1 TYR A   8      19.075  32.097  33.536  1.00 25.34   A
ATOM   4972  CD2 TYR A   8      20.319  30.843  35.674  1.00 25.72   A
ATOM   4973  CE2 TYR A   8      18.935  30.943  35.642  1.00 25.34   A
ATOM   4974  CZ  TYR A   8      18.315  31.571  34.570  1.00 25.28   A
ATOM   4975  OH  TYR A   8      16.945  31.672  34.539  1.00 24.76   A
ATOM   4976  C   TYR A   8      23.147  33.349  35.907  1.00 28.01   A
ATOM   4977  O   TYR A   8      24.086  33.591  36.667  1.00 28.14   A
ATOM   4978  N   PHE A   9      21.906  33.767  36.140  1.00 28.37   A
ATOM   4979  CA  PHE A   9      21.572  34.518  37.349  1.00 28.74   A
ATOM   4980  CB  PHE A   9      20.161  35.097  37.247  1.00 28.79   A
ATOM   4981  CG  PHE A   9      20.034  36.202  36.236  1.00 29.08   A
ATOM   4982  CD1 PHE A   9      19.031  36.169  35.273  1.00 29.16   A
ATOM   4983  CD2 PHE A   9      20.917  37.276  36.250  1.00 29.06   A
ATOM   4984  CE1 PHE A   9      18.905  37.192  34.335  1.00 29.23   A
ATOM   4985  CE2 PHE A   9      20.800  38.303  35.319  1.00 29.41   A
ATOM   4986  CZ  PHE A   9      19.792  38.260  34.357  1.00 29.36   A
ATOM   4987  C   PHE A   9      21.656  33.583  38.547  1.00 28.97   A
ATOM   4988  O   PHE A   9      21.790  32.369  38.385  1.00 29.03   A
ATOM   4989  N   ASN A  10      21.590  34.145  39.749  1.00 29.09   A
ATOM   4990  CA  ASN A  10      21.650  33.326  40.952  1.00 29.24   A
ATOM   4991  CB  ASN A  10      22.167  34.143  42.140  1.00 29.62   A
ATOM   4992  CG  ASN A  10      22.162  33.350  43.434  1.00 30.03   A
ATOM   4993  OD1 ASN A  10      22.370  32.134  43.432  1.00 30.13   A
ATOM   4994  ND2 ASN A  10      21.936  34.037  44.548  1.00 30.35   A
ATOM   4995  C   ASN A  10      20.276  32.753  41.266  1.00 29.04   A
ATOM   4996  O   ASN A  10      19.516  33.318  42.049  1.00 29.10   A
ATOM   4997  N   MET A  11      19.962  31.627  40.631  1.00 28.94   A
ATOM   4998  CA  MET A  11      18.685  30.942  40.824  1.00 28.66   A
ATOM   4999  CB  MET A  11      17.514  31.854  40.429  1.00 29.86   A
ATOM   5000  CG  MET A  11      17.483  32.272  38.969  1.00 31.35   A
ATOM   5001  SD  MET A  11      16.034  33.301  38.540  1.00 33.72   A
ATOM   5002  CE  MET A  11      16.695  34.947  38.769  1.00 33.16   A
ATOM   5003  C   MET A  11      18.663  29.681  39.972  1.00 27.66   A
ATOM   5004  O   MET A  11      19.541  29.479  39.139  1.00 27.28   A
ATOM   5005  N   ARG A  12      17.674  28.822  40.193  1.00 26.89   A
ATOM   5006  CA  ARG A  12      17.568  27.598  39.410  1.00 25.99   A
ATOM   5007  CB  ARG A  12      16.467  26.700  39.978  1.00 26.19   A
ATOM   5008  CG  ARG A  12      16.714  26.250  41.418  1.00 26.84   A
ATOM   5009  CD  ARG A  12      15.638  25.265  41.874  1.00 26.77   A
ATOM   5010  NE  ARG A  12      14.298  25.835  41.763  1.00 27.30   A
ATOM   5011  CZ  ARG A  12      13.794  26.737  42.598  1.00 27.44   A
ATOM   5012  NH1 ARG A  12      14.518  27.177  43.621  1.00 27.56   A
ATOM   5013  NH2 ARG A  12      12.570  27.209  42.404  1.00 27.81   A
ATOM   5014  C   ARG A  12      17.236  28.011  37.977  1.00 25.35   A
ATOM   5015  O   ARG A  12      18.030  27.800  37.065  1.00 25.01   A
ATOM   5016  N   GLY A  13      16.062  28.607  37.797  1.00 24.64   A
ATOM   5017  CA  GLY A  13      15.645  29.067  36.485  1.00 23.90   A
ATOM   5018  C   GLY A  13      15.900  28.126  35.326  1.00 23.52   A
ATOM   5019  O   GLY A  13      15.728  26.911  35.437  1.00 23.18   A
ATOM   5020  N   ARG A  14      16.333  28.696  34.205  1.00 22.72   A
ATOM   5021  CA  ARG A  14      16.592  27.920  32.998  1.00 22.38   A
ATOM   5022  CB  ARG A  14      16.417  28.824  31.781  1.00 22.47   A
ATOM   5023  CG  ARG A  14      15.004  29.342  31.659  1.00 22.96   A
ATOM   5024  CD  ARG A  14      14.807  30.214  30.443  1.00 23.81   A
ATOM   5025  NE  ARG A  14      13.386  30.325  30.135  1.00 24.80   A
ATOM   5026  CZ  ARG A  14      12.680  29.375  29.529  1.00 25.43   A
ATOM   5027  NH1 ARG A  14      13.267  28.245  29.154  1.00 25.67   A
ATOM   5028  NH2 ARG A  14      11.381  29.547  29.319  1.00 26.33   A
ATOM   5029  C   ARG A  14      17.946  27.221  32.940  1.00 21.87   A
ATOM   5030  O   ARG A  14      18.206  26.450  32.021  1.00 21.54   A
ATOM   5031  N   ALA A  15      18.811  27.474  33.914  1.00 21.26   A
ATOM   5032  CA  ALA A  15      20.109  26.826  33.910  1.00 20.98   A
ATOM   5033  CB  ALA A  15      21.180  27.785  34.416  1.00 21.37   A
ATOM   5034  C   ALA A  15      20.106  25.567  34.761  1.00 20.63   A
ATOM   5035  O   ALA A  15      21.055  24.785  34.724  1.00 20.56   A
ATOM   5036  N   GLU A  16      19.040  25.361  35.524  1.00 20.39   A
ATOM   5037  CA  GLU A  16      18.985  24.198  36.401  1.00 20.26   A
ATOM   5038  CB  GLU A  16      17.739  24.260  37.284  1.00 20.92   A
ATOM   5039  CG  GLU A  16      17.825  23.399  38.537  1.00 21.66   A
ATOM   5040  CD  GLU A  16      19.007  23.757  39.425  1.00 22.12   A
ATOM   5041  OE1 GLU A  16      19.405  24.943  39.461  1.00 22.58   A
ATOM   5042  OE2 GLU A  16      19.537  22.850  40.097  1.00 22.29   A
ATOM   5043  C   GLU A  16      19.030  22.871  35.656  1.00 19.57   A
ATOM   5044  O   GLU A  16      19.665  21.924  36.121  1.00 19.37   A
ATOM   5045  N   ILE A  17      18.371  22.791  34.502  1.00 19.00   A
ATOM   5046  CA  ILE A  17      18.374  21.539  33.749  1.00 18.27   A
ATOM   5047  CB  ILE A  17      17.459  21.621  32.483  1.00 18.13   A
ATOM   5048  CG2 ILE A  17      17.933  22.726  31.549  1.00 17.76   A
ATOM   5049  CG1 ILE A  17      17.431  20.262  31.771  1.00 17.74   A
ATOM   5050  CD1 ILE A  17      16.815  19.144  32.603  1.00 17.40   A
ATOM   5051  C   ILE A  17      19.795  21.141  33.354  1.00 18.40   A
ATOM   5052  O   ILE A  17      20.135  19.956  33.327  1.00 18.19   A
ATOM   5242  N   TRP A  39      24.784  42.507  34.947  1.00 44.42   A
ATOM   5243  CA  TRP A  39      24.103  41.994  33.763  1.00 44.13   A
ATOM   5244  CB  TRP A  39      22.630  41.726  34.082  1.00 44.08   A
ATOM   5245  CG  TRP A  39      21.834  41.243  32.905  1.00 44.04   A
ATOM   5246  CD2 TRP A  39      22.234  40.267  31.932  1.00 43.94   A
ATOM   5247  CE2 TRP A  39      21.162  40.122  31.023  1.00 43.97   A
ATOM   5248  CE3 TRP A  39      23.391  39.500  31.741  1.00 43.89   A
ATOM   5249  CD1 TRP A  39      20.576  41.637  32.555  1.00 44.04   A
ATOM   5250  NE1 TRP A  39      20.166  40.970  31.427  1.00 44.07   A
ATOM   5251  CZ2 TRP A  39      21.212  39.242  29.936  1.00 43.96   A
ATOM   5252  CZ3 TRP A  39      23.442  38.623  30.657  1.00 43.92   A
ATOM   5253  CH2 TRP A  39      22.356  38.503  29.770  1.00 43.91   A
ATOM   5254  C   TRP A  39      24.202  42.927  32.553  1.00 44.00   A
ATOM   5255  O   TRP A  39      24.614  42.507  31.472  1.00 43.93   A
ATOM   5256  N   PRO A  40      23.828  44.207  32.720  1.00 43.84   A
ATOM   5257  CD  PRO A  40      23.435  44.869  33.978  1.00 43.81   A
ATOM   5258  CA  PRO A  40      23.881  45.178  31.622  1.00 43.62   A
ATOM   5259  CB  PRO A  40      23.764  46.516  32.347  1.00 43.72   A
ATOM   5260  CG  PRO A  40      22.860  46.182  33.488  1.00 43.84   A
ATOM   5261  C   PRO A  40      25.141  45.091  30.760  1.00 43.33   A
ATOM   5262  O   PRO A  40      25.059  45.100  29.533  1.00 43.30   A
ATOM   5263  N   GLU A  41      26.301  45.003  31.402  1.00 42.98   A
ATOM   5264  CA  GLU A  41      27.569  44.921  30.681  1.00 42.61   A
ATOM   5265  CB  GLU A  41      28.741  45.127  31.647  1.00 43.08   A
ATOM   5266  CG  GLU A  41      30.113  44.941  31.007  1.00 43.66   A
ATOM   5267  CD  GLU A  41      30.405  45.969  29.924  1.00 44.03   A
ATOM   5268  OE1 GLU A  41      31.411  45.800  29.198  1.00 44.15   A
ATOM   5269  OE2 GLU A  41      29.633  46.946  29.804  1.00 44.31   A
ATOM   5270  C   GLU A  41      27.742  43.593  29.953  1.00 42.03   A
ATOM   5271  O   GLU A  41      28.054  43.560  28.761  1.00 42.06   A
ATOM   5272  N   ILE A  42      27.541  42.501  30.681  1.00 41.22   A
ATOM   5273  CA  ILE A  42      27.682  41.162  30.124  1.00 40.49   A
ATOM   5274  CB  ILE A  42      27.419  40.098  31.209  1.00 40.55   A
ATOM   5275  CG2 ILE A  42      27.600  38.703  30.631  1.00 40.56   A
ATOM   5276  CG1 ILE A  42      28.376  40.319  32.382  1.00 40.56   A
ATOM   5277  CD1 ILE A  42      28.048  39.497  33.608  1.00 40.65   A
ATOM   5278  C   ILE A  42      26.722  40.933  28.959  1.00 39.90   A
ATOM   5279  O   ILE A  42      27.076  40.294  27.971  1.00 39.65   A
ATOM   5280  N   LYS A  43      25.511  41.468  29.083  1.00 39.26   A
ATOM   5281  CA  LYS A  43      24.485  41.321  28.055  1.00 38.70   A
ATOM   5282  CB  LYS A  43      23.218  42.066  28.482  1.00 38.64   A
ATOM   5283  CG  LYS A  43      22.040  41.922  27.529  1.00 38.63   A
ATOM   5284  CD  LYS A  43      20.862  42.769  27.995  1.00 38.51   A
ATOM   5285  CE  LYS A  43      19.702  42.725  27.010  1.00 38.59   A
ATOM   5286  NZ  LYS A  43      19.088  41.374  26.908  1.00 38.47   A
ATOM   5287  C   LYS A  43      24.941  41.821  26.682  1.00 38.32   A
ATOM   5288  O   LYS A  43      24.657  41.195  25.656  1.00 38.07   A
ATOM   5328  N   GLY A  49      22.169  38.393  23.696  1.00 27.72   A
ATOM   5329  CA  GLY A  49      21.892  39.053  24.959  1.00 26.80   A
ATOM   5330  C   GLY A  49      20.981  38.310  25.914  1.00 26.17   A
ATOM   5331  O   GLY A  49      20.163  38.922  26.607  1.00 25.97   A
ATOM   5332  N   LYS A  50      21.123  36.991  25.961  1.00 25.32   A
ATOM   5333  CA  LYS A  50      20.301  36.179  26.845  1.00 24.71   A
ATOM   5334  CB  LYS A  50      19.164  35.522  26.052  1.00 25.17   A
ATOM   5335  CG  LYS A  50      18.256  36.493  25.314  1.00 26.18   A
ATOM   5336  CD  LYS A  50      17.362  37.263  26.267  1.00 26.58   A
ATOM   5337  CE  LYS A  50      16.619  38.387  25.552  1.00 27.00   A
ATOM   5338  NZ  LYS A  50      15.862  37.901  24.367  1.00 27.09   A
ATOM   5339  C   LYS A  50      21.114  35.095  27.527  1.00 24.20   A
ATOM   5340  O   LYS A  50      22.118  34.625  26.994  1.00 23.51   A
ATOM   5341  N   ILE A  51      20.672  34.705  28.716  1.00 23.62   A
ATOM   5342  CA  ILE A  51      21.329  33.642  29.462  1.00 23.69   A
ATOM   5343  CB  ILE A  51      22.023  34.170  30.743  1.00 23.40   A
ATOM   5344  CG2 ILE A  51      23.331  34.852  30.373  1.00 23.31   A
ATOM   5345  CG1 ILE A  51      21.086  35.106  31.510  1.00 23.39   A
ATOM   5346  CD1 ILE A  51      21.696  35.661  32.779  1.00 23.78   A
ATOM   5347  C   ILE A  51      20.270  32.609  29.822  1.00 23.77   A
ATOM   5348  O   ILE A  51      19.074  32.888  29.754  1.00 23.72   A
ATOM   5349  N   PRO A  52      20.697  31.411  30.239  1.00 24.02   A
ATOM   5350  CD  PRO A  52      19.778  30.321  30.607  1.00 24.22   A
ATOM   5351  CA  PRO A  52      22.089  30.979  30.378  1.00 24.24   A
ATOM   5352  CB  PRO A  52      21.958  29.708  31.211  1.00 24.34   A
ATOM   5353  CG  PRO A  52      20.692  29.124  30.659  1.00 24.40   A
ATOM   5354  C   PRO A  52      22.843  30.711  29.082  1.00 24.32   A
ATOM   5355  O   PRO A  52      22.258  30.608  27.999  1.00 24.21   A
ATOM   5356  N   ILE A  53      24.160  30.614  29.214  1.00 24.37   A
ATOM   5357  CA  ILE A  53      25.030  30.287  28.099  1.00 24.60   A
ATOM   5358  CB  ILE A  53      25.771  31.517  27.524  1.00 24.79   A
ATOM   5359  CG2 ILE A  53      24.772  32.471  26.876  1.00 24.74   A
ATOM   5360  CG1 ILE A  53      26.583  32.210  28.623  1.00 24.92   A
ATOM   5361  CD1 ILE A  53      27.597  33.207  28.088  1.00 25.21   A
ATOM   5362  C   ILE A  53      26.051  29.318  28.659  1.00 24.74   A
ATOM   5363  O   ILE A  53      26.312  29.312  29.864  1.00 24.56   A
ATOM   5423  N   HIS A  62      24.282  28.843  23.471  1.00 20.06   A
ATOM   5424  CA  HIS A  62      23.143  29.461  24.151  1.00 19.14   A
ATOM   5425  CB  HIS A  62      22.885  30.885  23.631  1.00 19.13   A
ATOM   5426  CG  HIS A  62      22.437  30.944  22.205  1.00 19.63   A
ATOM   5427  CD2 HIS A  62      21.300  31.421  21.646  1.00 19.62   A
ATOM   5428  ND1 HIS A  62      23.222  30.509  21.159  1.00 20.17   A
ATOM   5429  CE1 HIS A  62      22.592  30.721  20.018  1.00 19.92   A
ATOM   5430  NE2 HIS A  62      21.423  31.275  20.285  1.00 20.10   A
ATOM   5431  C   HIS A  62      21.887  28.607  24.010  1.00 18.09   A
ATOM   5432  O   HIS A  62      21.914  27.591  23.321  1.00 17.56   A
ATOM   5433  N   GLN A  63      20.804  29.046  24.659  1.00 17.49   A
ATOM   5434  CA  GLN A  63      19.512  28.342  24.693  1.00 16.80   A
ATOM   5435  CB  GLN A  63      19.042  27.971  23.285  1.00 17.09   A
ATOM   5436  CG  GLN A  63      18.397  29.137  22.515  1.00 17.33   A
ATOM   5437  CD  GLN A  63      17.113  29.658  23.165  1.00 17.51   A
ATOM   5438  OE1 GLN A  63      16.514  28.993  24.013  1.00 17.71   A
ATOM   5439  NE2 GLN A  63      16.676  30.846  22.750  1.00 18.20   A
ATOM   5440  C   GLN A  63      19.621  27.095  25.575  1.00 16.48   A
ATOM   5441  O   GLN A  63      20.248  26.098  25.202  1.00 15.97   A
ATOM   5442  N   SER A  64      18.983  27.166  26.740  1.00 16.15   A
ATOM   5443  CA  SER A  64      19.038  26.099  27.733  1.00 16.55   A
ATOM   5444  CB  SER A  64      18.163  26.463  28.948  1.00 16.41   A
ATOM   5445  OG  SER A  64      16.780  26.507  28.637  1.00 17.25   A
ATOM   5446  C   SER A  64      18.705  24.688  27.258  1.00 16.42   A
ATOM   5447  O   SER A  64      19.395  23.736  27.625  1.00 16.29   A
ATOM   5448  N   LEU A  65      17.661  24.545  26.449  1.00 16.61   A
ATOM   5449  CA  LEU A  65      17.266  23.221  25.979  1.00 16.62   A
ATOM   5450  CB  LEU A  65      15.803  23.242  25.518  1.00 17.28   A
ATOM   5451  CG  LEU A  65      14.804  23.694  26.599  1.00 17.94   A
ATOM   5452  CD1 LEU A  65      13.381  23.514  26.100  1.00 18.29   A
ATOM   5453  CD2 LEU A  65      15.023  22.904  27.884  1.00 18.01   A
ATOM   5454  C   LEU A  65      18.183  22.699  24.874  1.00 16.53   A
ATOM   5455  O   LEU A  65      18.384  21.484  24.739  1.00 16.69   A
ATOM   5662  N   ASP A  93       9.437  20.470  25.569  1.00 14.02   A
ATOM   5663  CA  ASP A  93       8.852  21.675  24.974  1.00 15.28   A
ATOM   5664  CB  ASP A  93       8.823  21.563  23.440  1.00 16.56   A
ATOM   5665  CG  ASP A  93      10.139  22.002  22.800  1.00 18.16   A
ATOM   5666  OD1 ASP A  93      10.212  22.113  21.549  1.00 19.71   A
ATOM   5667  OD2 ASP A  93      11.116  22.243  23.549  1.00 19.34   A
ATOM   5668  C   ASP A  93       7.457  22.002  25.521  1.00 15.10   A
ATOM   5669  O   ASP A  93       7.103  23.178  25.671  1.00 15.47   A
ATOM   5670  N   THR A  94       6.662  20.973  25.813  1.00 14.79   A
ATOM   5671  CA  THR A  94       5.327  21.184  26.365  1.00 14.62   A
ATOM   5672  CB  THR A  94       4.568  19.838  26.465  1.00 14.82   A
ATOM   5673  OG1 THR A  94       4.196  19.423  25.140  1.00 14.81   A
ATOM   5674  CG2 THR A  94       3.298  19.969  27.309  1.00 15.03   A
ATOM   5675  C   THR A  94       5.475  21.860  27.736  1.00 15.22   A
ATOM   5676  O   THR A  94       4.758  22.805  28.051  1.00 14.83   A
ATOM   5677  N   LEU A  95       6.424  21.390  28.533  1.00 15.45   A
ATOM   5678  CA  LEU A  95       6.664  21.978  29.846  1.00 16.14   A
ATOM   5679  CB  LEU A  95       7.663  21.130  30.630  1.00 16.28   A
ATOM   5680  CG  LEU A  95       7.107  19.798  31.120  1.00 16.61   A
ATOM   5681  CD1 LEU A  95       8.245  18.898  31.594  1.00 16.85   A
ATOM   5682  CD2 LEU A  95       6.103  20.052  32.240  1.00 17.08   A
ATOM   5683  C   LEU A  95       7.215  23.388  29.693  1.00 16.49   A
ATOM   5684  O   LEU A  95       6.745  24.327  30.344  1.00 16.45   A
ATOM   5685  N   ASP A  96       8.208  23.540  28.823  1.00 16.67   A
ATOM   5686  CA  ASP A  96       8.824  24.850  28.621  1.00 17.83   A
ATOM   5687  CB  ASP A  96      10.001  24.736  27.646  1.00 18.40   A
ATOM   5688  CG  ASP A  96      11.004  25.860  27.815  1.00 19.35   A
ATOM   5689  OD1 ASP A  96      11.519  26.027  28.946  1.00 20.31   A
ATOM   5690  OD2 ASP A  96      11.278  26.572  26.827  1.00 19.91   A
ATOM   5691  C   ASP A  96       7.817  25.883  28.119  1.00 18.10   A
ATOM   5692  O   ASP A  96       7.850  27.046  28.536  1.00 17.78   A
ATOM   5693  N   ASP A  97       6.918  25.464  27.230  1.00 18.27   A
ATOM   5694  CA  ASP A  97       5.902  26.376  26.700  1.00 18.83   A
ATOM   5695  CB  ASP A  97       4.957  25.644  25.741  1.00 19.25   A
ATOM   5696  CG  ASP A  97       5.582  25.365  24.386  1.00 20.04   A
ATOM   5697  OD1 ASP A  97       4.980  24.595  23.611  1.00 20.50   A
ATOM   5698  OD2 ASP A  97       6.660  25.914  24.085  1.00 20.61   A
ATOM   5699  C   ASP A  97       5.070  26.968  27.835  1.00 18.89   A
ATOM   5700  O   ASP A  97       4.828  28.175  27.878  1.00 18.39   A
ATOM   5701  N   PHE A  98       4.630  26.107  28.750  1.00 19.13   A
ATOM   5702  CA  PHE A  98       3.814  26.547  29.875  1.00 19.65   A
ATOM   5703  CB  PHE A  98       3.311  25.342  30.686  1.00 20.03   A
ATOM   5704  CG  PHE A  98       2.426  25.718  31.854  1.00 20.47   A
ATOM   5705  CD1 PHE A  98       1.249  26.436  31.650  1.00 20.90   A
ATOM   5706  CD2 PHE A  98       2.794  25.390  33.159  1.00 20.78   A
ATOM   5707  CE1 PHE A  98       0.451  26.827  32.732  1.00 21.07   A
ATOM   5708  CE2 PHE A  98       2.007  25.773  34.246  1.00 21.32   A
ATOM   5709  CZ  PHE A  98       0.837  26.495  34.035  1.00 21.00   A
ATOM   5710  C   PHE A  98       4.598  27.495  30.776  1.00 20.02   A
ATOM   5711  O   PHE A  98       4.125  28.583  31.089  1.00 20.09   A
ATOM   5712  N   MET A  99       5.793  27.090  31.195  1.00 20.31   A
ATOM   5713  CA  MET A  99       6.607  27.937  32.064  1.00 21.46   A
ATOM   5714  CB  MET A  99       7.934  27.249  32.397  1.00 21.92   A
ATOM   5715  CG  MET A  99       7.805  25.906  33.110  1.00 22.64   A
ATOM   5716  SD  MET A  99       6.818  25.981  34.620  1.00 23.36   A
ATOM   5717  CE  MET A  99       7.919  26.938  35.719  1.00 23.75   A
ATOM   5718  C   MET A  99       6.885  29.294  31.416  1.00 21.88   A
ATOM   5719  O   MET A  99       6.921  30.321  32.101  1.00 21.92   A
ATOM   5720  N   SER A 100       7.068  29.297  30.097  1.00 22.34   A
ATOM   5721  CA  SER A 100       7.356  30.530  29.359  1.00 23.09   A
ATOM   5722  CB  SER A 100       7.848  30.196  27.946  1.00 22.97   A
ATOM   5723  OG  SER A 100       9.105  29.535  27.992  1.00 22.88   A
ATOM   5724  C   SER A 100       6.169  31.486  29.280  1.00 23.87   A
ATOM   5725  O   SER A 100       6.337  32.665  28.953  1.00 23.83   A
ATOM   5726  N   CYS A 101       4.973  30.980  29.569  1.00 24.59   A
ATOM   5727  CA  CYS A 101       3.769  31.812  29.551  1.00 25.73   A
ATOM   5728  CB  CYS A 101       2.504  30.950  29.642  1.00 26.18   A
ATOM   5729  SG  CYS A 101       2.072  30.045  28.134  1.00 27.14   A
ATOM   5730  C   CYS A 101       3.764  32.802  30.711  1.00 26.07   A
ATOM   5731  O   CYS A 101       3.164  33.869  30.611  1.00 26.17   A
ATOM   5732  N   PHE A 102       4.424  32.452  31.814  1.00 26.61   A
ATOM   5733  CA  PHE A 102       4.448  33.344  32.969  1.00 27.42   A
ATOM   5734  CB  PHE A 102       4.968  32.621  34.218  1.00 27.19   A
ATOM   5735  CG  PHE A 102       4.090  31.491  34.683  1.00 26.99   A
ATOM   5736  CD1 PHE A 102       4.118  30.261  34.035  1.00 26.96   A
ATOM   5737  CD2 PHE A 102       3.232  31.657  35.769  1.00 27.14   A
ATOM   5738  CE1 PHE A 102       3.308  29.205  34.459  1.00 27.01   A
ATOM   5739  CE2 PHE A 102       2.418  30.609  36.202  1.00 26.99   A
ATOM   5740  CZ  PHE A 102       2.456  29.378  35.542  1.00 27.14   A
ATOM   5741  C   PHE A 102       5.298  34.587  32.719  1.00 27.95   A
ATOM   5742  O   PHE A 102       6.423  34.495  32.237  1.00 27.67   A
ATOM   5743  N   PRO A 103       4.761  35.774  33.045  1.00 28.91   A
ATOM   5744  CD  PRO A 103       3.381  36.039  33.496  1.00 29.00   A
ATOM   5745  CA  PRO A 103       5.496  37.027  32.845  1.00 29.76   A
ATOM   5746  CB  PRO A 103       4.381  38.061  32.792  1.00 29.51   A
ATOM   5747  CG  PRO A 103       3.410  37.534  33.798  1.00 29.21   A
ATOM   5748  C   PRO A 103       6.470  37.276  33.995  1.00 30.76   A
ATOM   5749  O   PRO A 103       6.244  38.155  34.828  1.00 30.85   A
ATOM   5750  N   TRP A 104       7.555  36.508  34.027  1.00 31.83   A
ATOM   5751  CA  TRP A 104       8.551  36.628  35.089  1.00 33.11   A
ATOM   5752  CB  TRP A 104       9.647  35.572  34.917  1.00 32.91   A
ATOM   5753  CG  TRP A 104       9.124  34.178  34.737  1.00 32.96   A
ATOM   5754  CD2 TRP A 104       8.713  33.275  35.772  1.00 32.96   A
ATOM   5755  CE2 TRP A 104       8.269  32.092  35.141  1.00 33.00   A
ATOM   5756  CE3 TRP A 104       8.677  33.351  37.174  1.00 33.00   A
ATOM   5757  CD1 TRP A 104       8.918  33.525  33.555  1.00 32.88   A
ATOM   5758  NE1 TRP A 104       8.405  32.271  33.789  1.00 32.93   A
ATOM   5759  CZ2 TRP A 104       7.792  30.992  35.862  1.00 33.01   A
ATOM   5760  CZ3 TRP A 104       8.201  32.255  37.890  1.00 33.07   A
ATOM   5761  CH2 TRP A 104       7.766  31.093  37.231  1.00 32.98   A
ATOM   5762  C   TRP A 104       9.205  38.003  35.194  1.00 34.03   A
ATOM   5763  O   TRP A 104       9.515  38.460  36.291  1.00 34.18   A
ATOM   5764  N   ALA A 105       9.414  38.657  34.055  1.00 35.15   A
ATOM   5765  CA  ALA A 105      10.052  39.972  34.038  1.00 36.46   A
ATOM   5766  CB  ALA A 105      10.943  40.095  32.804  1.00 36.36   A
ATOM   5767  C   ALA A 105       9.054  41.128  34.075  1.00 37.41   A
ATOM   5768  O   ALA A 105       9.450  42.294  34.080  1.00 37.56   A
ATOM   5769  N   GLU A 106       7.765  40.806  34.101  1.00 38.52   A
ATOM   5770  CA  GLU A 106       6.723  41.828  34.133  1.00 39.67   A
ATOM   5771  CB  GLU A 106       5.344  41.166  34.069  1.00 39.95   A
ATOM   5772  CG  GLU A 106       4.165  42.130  34.045  1.00 40.21   A
ATOM   5773  CD  GLU A 106       4.304  43.209  32.989  1.00 40.48   A
ATOM   5774  OE1 GLU A 106       4.932  44.251  33.276  1.00 40.68   A
ATOM   5775  OE2 GLU A 106       3.796  43.014  31.864  1.00 40.58   A
ATOM   5776  C   GLU A 106       6.819  42.701  35.381  1.00 40.42   A
ATOM   5777  O   GLU A 106       6.609  42.231  36.500  1.00 40.56   A
ATOM   5778  N   LYS A 107       7.136  43.978  35.189  1.00 41.30   A
ATOM   5779  CA  LYS A 107       7.250  44.895  36.315  1.00 42.22   A
ATOM   5780  CB  LYS A 107       8.092  46.110  35.927  1.00 42.33   A
ATOM   5781  CG  LYS A 107       9.587  45.866  36.016  1.00 42.56   A
ATOM   5782  CD  LYS A 107      10.000  45.596  37.457  1.00 42.79   A
ATOM   5783  CE  LYS A 107      11.501  45.396  37.583  1.00 42.86   A
ATOM   5784  NZ  LYS A 107      12.264  46.598  37.132  1.00 43.08   A
ATOM   5785  C   LYS A 107       5.890  45.343  36.831  1.00 42.73   A
ATOM   5786  O   LYS A 107       5.719  45.571  38.030  1.00 42.99   A
ATOM   5787  N   LYS A 108       4.925  45.465  35.927  1.00 43.26   A
ATOM   5788  CA  LYS A 108       3.575  45.875  36.299  1.00 43.78   A
ATOM   5789  CB  LYS A 108       2.734  46.106  35.041  1.00 43.97   A
ATOM   5790  CG  LYS A 108       3.322  47.146  34.099  1.00 44.32   A
ATOM   5791  CD  LYS A 108       2.459  47.357  32.862  1.00 44.57   A
ATOM   5792  CE  LYS A 108       2.469  46.142  31.950  1.00 44.80   A
ATOM   5793  NZ  LYS A 108       1.672  46.386  30.716  1.00 45.09   A
ATOM   5794  C   LYS A 108       2.937  44.793  37.169  1.00 44.07   A
ATOM   5795  O   LYS A 108       2.342  43.841  36.662  1.00 44.03   A
ATOM   5796  N   GLN A 109       3.069  44.954  38.483  1.00 44.42   A
ATOM   5797  CA  GLN A 109       2.535  44.001  39.453  1.00 44.80   A
ATOM   5798  CB  GLN A 109       2.686  44.569  40.870  1.00 45.10   A
ATOM   5799  CG  GLN A 109       2.511  43.547  41.989  1.00 45.66   A
ATOM   5800  CD  GLN A 109       3.703  42.612  42.129  1.00 45.85   A
ATOM   5801  OE1 GLN A 109       3.740  41.763  43.022  1.00 46.01   A
ATOM   5802  NE2 GLN A 109       4.688  42.767  41.247  1.00 46.00   A
ATOM   5803  C   GLN A 109       1.070  43.648  39.197  1.00 44.83   A
ATOM   5804  O   GLN A 109       0.675  42.484  39.288  1.00 44.88   A
ATOM   5805  N   ASP A 110       0.267  44.656  38.876  1.00 44.78   A
ATOM   5806  CA  ASP A 110      -1.153  44.451  38.616  1.00 44.83   A
ATOM   5807  CB  ASP A 110      -1.816  45.784  38.257  1.00 45.28   A
ATOM   5808  CG  ASP A 110      -1.243  46.399  36.992  1.00 45.63   A
ATOM   5809  OD1 ASP A 110      -0.023  46.675  36.958  1.00 45.86   A
ATOM   5810  OD2 ASP A 110      -2.016  46.605  36.030  1.00 46.00   A
ATOM   5811  C   ASP A 110      -1.399  43.437  37.496  1.00 44.67   A
ATOM   5812  O   ASP A 110      -2.296  42.600  37.590  1.00 44.60   A
ATOM   5813  N   VAL A 111      -0.597  43.519  36.439  1.00 44.34   A
ATOM   5814  CA  VAL A 111      -0.730  42.621  35.298  1.00 44.07   A
ATOM   5815  CB  VAL A 111      -0.112  43.254  34.031  1.00 44.24   A
ATOM   5816  CG1 VAL A 111      -0.338  42.352  32.828  1.00 44.21   A
ATOM   5817  CG2 VAL A 111      -0.718  44.628  33.794  1.00 44.30   A
ATOM   5818  C   VAL A 111      -0.058  41.273  35.556  1.00 43.75   A
ATOM   5819  O   VAL A 111      -0.571  40.229  35.157  1.00 43.61   A
ATOM   5820  N   LYS A 112       1.088  41.305  36.227  1.00 43.49   A
ATOM   5821  CA  LYS A 112       1.834  40.093  36.534  1.00 43.29   A
ATOM   5822  CB  LYS A 112       3.161  40.452  37.207  1.00 43.21   A
ATOM   5823  CG  LYS A 112       4.040  39.255  37.531  1.00 43.24   A
ATOM   5824  CD  LYS A 112       5.354  39.686  38.160  1.00 43.22   A
ATOM   5825  CE  LYS A 112       6.284  38.499  38.369  1.00 43.30   A
ATOM   5826  NZ  LYS A 112       7.585  38.911  38.962  1.00 43.09   A
ATOM   5827  C   LYS A 112       1.036  39.159  37.440  1.00 43.21   A
ATOM   5828  O   LYS A 112       0.865  37.976  37.136  1.00 43.01   A
ATOM   5829  N   GLU A 113       0.547  39.703  38.551  1.00 43.11   A
ATOM   5830  CA  GLU A 113      -0.230  38.935  39.521  1.00 42.91   A
ATOM   5831  CB  GLU A 113      -0.676  39.849  40.670  1.00 43.22   A
ATOM   5832  CG  GLU A 113      -1.401  39.138  41.808  1.00 43.46   A
ATOM   5833  CD  GLU A 113      -0.473  38.290  42.660  1.00 43.66   A
ATOM   5834  OE1 GLU A 113      -0.951  37.683  43.644  1.00 43.73   A
ATOM   5835  OE2 GLU A 113       0.738  38.232  42.348  1.00 43.75   A
ATOM   5836  C   GLU A 113      -1.460  38.288  38.884  1.00 42.68   A
ATOM   5837  O   GLU A 113      -1.799  37.142  39.187  1.00 42.56   A
ATOM   5838  N   GLN A 114      -2.121  39.031  38.002  1.00 42.28   A
ATOM   5839  CA  GLN A 114      -3.323  38.552  37.326  1.00 41.94   A
ATOM   5840  CB  GLN A 114      -3.979  39.712  36.568  1.00 42.26   A
ATOM   5841  CG  GLN A 114      -5.404  39.462  36.083  1.00 42.72   A
ATOM   5842  CD  GLN A 114      -5.470  38.624  34.821  1.00 42.97   A
ATOM   5843  OE1 GLN A 114      -4.796  38.918  33.830  1.00 43.14   A
ATOM   5844  NE2 GLN A 114      -6.302  37.584  34.841  1.00 43.11   A
ATOM   5845  C   GLN A 114      -3.030  37.396  36.372  1.00 41.52   A
ATOM   5846  O   GLN A 114      -3.796  36.435  36.294  1.00 41.60   A
ATOM   5847  N   MET A 115      -1.919  37.488  35.648  1.00 40.93   A
ATOM   5848  CA  MET A 115      -1.549  36.439  34.706  1.00 40.35   A
ATOM   5849  CB  MET A 115      -0.437  36.930  33.774  1.00 40.74   A
ATOM   5850  CG  MET A 115      -0.045  35.930  32.692  1.00 41.32   A
ATOM   5851  SD  MET A 115      -1.436  35.356  31.684  1.00 42.13   A
ATOM   5852  CE  MET A 115      -1.186  36.293  30.162  1.00 42.02   A
ATOM   5853  C   MET A 115      -1.105  35.168  35.436  1.00 39.61   A
ATOM   5854  O   MET A 115      -1.398  34.059  34.990  1.00 39.35   A
ATOM   5855  N   PHE A 116      -0.405  35.332  36.556  1.00 38.88   A
ATOM   5856  CA  PHE A 116       0.056  34.188  37.335  1.00 38.26   A
ATOM   5857  CB  PHE A 116       0.942  34.638  38.501  1.00 38.13   A
ATOM   5858  CG  PHE A 116       2.406  34.690  38.170  1.00 37.93   A
ATOM   5859  CD1 PHE A 116       2.893  35.593  37.232  1.00 37.95   A
ATOM   5860  CD2 PHE A 116       3.304  33.838  38.808  1.00 37.87   A
ATOM   5861  CE1 PHE A 116       4.254  35.646  36.930  1.00 37.97   A
ATOM   5862  CE2 PHE A 116       4.665  33.882  38.514  1.00 37.79   A
ATOM   5863  CZ  PHE A 116       5.141  34.789  37.575  1.00 37.96   A
ATOM   5864  C   PHE A 116      -1.114  33.385  37.886  1.00 38.04   A
ATOM   5865  O   PHE A 116      -1.147  32.161  37.769  1.00 37.81   A
ATOM   6152  N   TYR A 152      13.539  17.574  33.797  1.00 16.38   A
ATOM   6153  CA  TYR A 152      12.825  18.812  33.538  1.00 16.80   A
ATOM   6154  CB  TYR A 152      12.658  19.044  32.028  1.00 17.06   A
ATOM   6155  CG  TYR A 152      12.623  20.514  31.669  1.00 17.96   A
ATOM   6156  CD1 TYR A 152      13.677  21.359  32.026  1.00 18.34   A
ATOM   6157  CE1 TYR A 152      13.642  22.720  31.737  1.00 19.38   A
ATOM   6158  CD2 TYR A 152      11.530  21.074  31.003  1.00 17.98   A
ATOM   6159  CE2 TYR A 152      11.491  22.442  30.706  1.00 19.01   A
ATOM   6160  CZ  TYR A 152      12.548  23.256  31.077  1.00 19.24   A
ATOM   6161  OH  TYR A 152      12.517  24.604  30.789  1.00 20.15   A
ATOM   6162  C   TYR A 152      11.470  18.861  34.239  1.00 16.67   A
ATOM   6163  O   TYR A 152      11.031  19.932  34.652  1.00 16.60   A
ATOM   6164  N   TRP A 153      10.804  17.713  34.379  1.00 16.52   A
ATOM   6165  CA  TRP A 153       9.518  17.691  35.071  1.00 16.67   A
ATOM   6166  CB  TRP A 153       8.870  16.299  35.002  1.00 16.89   A
ATOM   6167  CG  TRP A 153       7.851  16.082  36.080  1.00 17.11   A
ATOM   6168  CD2 TRP A 153       6.691  16.883  36.345  1.00 17.34   A
ATOM   6169  CE2 TRP A 153       6.067  16.349  37.496  1.00 17.61   A
ATOM   6170  CE3 TRP A 153       6.122  18.001  35.726  1.00 17.51   A
ATOM   6171  CD1 TRP A 153       7.879  15.120  37.053  1.00 17.56   A
ATOM   6172  NE1 TRP A 153       6.815  15.278  37.906  1.00 17.47   A
ATOM   6173  CZ2 TRP A 153       4.893  16.893  38.038  1.00 17.62   A
ATOM   6174  CZ3 TRP A 153       4.954  18.548  36.264  1.00 17.52   A
ATOM   6175  CH2 TRP A 153       4.352  17.990  37.410  1.00 17.93   A
ATOM   6176  C   TRP A 153       9.719  18.073  36.540  1.00 16.90   A
ATOM   6177  O   TRP A 153       8.963  18.874  37.101  1.00 16.93   A
ATOM   6178  N   GLU A 154      10.746  17.502  37.156  1.00 16.92   A
ATOM   6179  CA  GLU A 154      11.035  17.762  38.561  1.00 17.77   A
ATOM   6180  CB  GLU A 154      12.168  16.846  39.037  1.00 18.50   A
ATOM   6181  CG  GLU A 154      12.341  16.793  40.555  1.00 20.34   A
ATOM   6182  CD  GLU A 154      13.143  17.942  41.115  1.00 21.37   A
ATOM   6183  OE1 GLU A 154      13.106  18.142  42.352  1.00 22.31   A
ATOM   6184  OE2 GLU A 154      13.825  18.645  40.336  1.00 22.41   A
ATOM   6185  C   GLU A 154      11.409  19.223  38.779  1.00 17.80   A
ATOM   6186  O   GLU A 154      10.992  19.841  39.765  1.00 17.40   A
ATOM   6187  N   ILE A 155      12.189  19.766  37.848  1.00 17.91   A
ATOM   6188  CA  ILE A 155      12.632  21.158  37.916  1.00 18.46   A
ATOM   6189  CB  ILE A 155      13.704  21.442  36.837  1.00 18.42   A
ATOM   6190  CG2 ILE A 155      13.999  22.953  36.754  1.00 18.94   A
ATOM   6191  CG1 ILE A 155      14.972  20.643  37.160  1.00 18.56   A
ATOM   6192  CD1 ILE A 155      16.070  20.752  36.113  1.00 17.73   A
ATOM   6193  C   ILE A 155      11.468  22.133  37.748  1.00 18.60   A
ATOM   6194  O   ILE A 155      11.320  23.084  38.527  1.00 18.55   A
ATOM   6195  N   CYS A 156      10.640  21.901  36.734  1.00 18.62   A
ATOM   6196  CA  CYS A 156       9.495  22.768  36.498  1.00 19.08   A
ATOM   6197  CB  CYS A 156       8.808  22.418  35.170  1.00 19.21   A
ATOM   6198  SG  CYS A 156       9.783  22.809  33.694  1.00 20.15   A
ATOM   6199  C   CYS A 156       8.479  22.675  37.633  1.00 18.95   A
ATOM   6200  O   CYS A 156       7.950  23.689  38.082  1.00 19.21   A
ATOM   6201  N   SER A 157       8.210  21.461  38.108  1.00 18.70   A
ATOM   6202  CA  SER A 157       7.229  21.301  39.175  1.00 18.57   A
ATOM   6203  CB  SER A 157       6.890  19.820  39.388  1.00 18.17   A
ATOM   6204  OG  SER A 157       8.042  19.055  39.674  1.00 18.09   A
ATOM   6205  C   SER A 157       7.715  21.933  40.476  1.00 18.73   A
ATOM   6206  O   SER A 157       6.911  22.420  41.269  1.00 18.90   A
ATOM   6207  N   THR A 158       9.025  21.928  40.694  1.00 18.86   A
ATOM   6208  CA  THR A 158       9.586  22.536  41.898  1.00 19.39   A
ATOM   6209  CB  THR A 158      11.124  22.436  41.915  1.00 19.38   A
ATOM   6210  OG1 THR A 158      11.513  21.058  41.992  1.00 19.86   A
ATOM   6211  CG2 THR A 158      11.697  23.181  43.111  1.00 19.72   A
ATOM   6212  C   THR A 158       9.180  24.011  41.953  1.00 19.58   A
ATOM   6213  O   THR A 158       8.727  24.502  42.989  1.00 19.55   A
ATOM   6214  N   THR A 159       9.336  24.714  40.836  1.00 19.71   A
ATOM   6215  CA  THR A 159       8.977  26.129  40.791  1.00 20.16   A
ATOM   6216  CB  THR A 159       9.553  26.810  39.531  1.00 20.13   A
ATOM   6217  OG1 THR A 159      10.981  26.811  39.617  1.00 20.61   A
ATOM   6218  CG2 THR A 159       9.067  28.255  39.425  1.00 20.46   A
ATOM   6219  C   THR A 159       7.468  26.347  40.855  1.00 20.37   A
ATOM   6220  O   THR A 159       6.996  27.261  41.529  1.00 20.42   A
ATOM   6221  N   LEU A 160       6.701  25.509  40.163  1.00 20.18   A
ATOM   6222  CA  LEU A 160       5.258  25.651  40.195  1.00 20.20   A
ATOM   6223  CB  LEU A 160       4.607  24.665  39.229  1.00 20.20   A
ATOM   6224  CG  LEU A 160       4.790  24.985  37.742  1.00 20.36   A
ATOM   6225  CD1 LEU A 160       4.148  23.883  36.919  1.00 20.38   A
ATOM   6226  CD2 LEU A 160       4.171  26.340  37.411  1.00 20.08   A
ATOM   6227  C   LEU A 160       4.720  25.430  41.607  1.00 20.21   A
ATOM   6228  O   LEU A 160       3.812  26.133  42.043  1.00 19.87   A
ATOM   6229  N   LEU A 161       5.290  24.459  42.321  1.00 20.19   A
ATOM   6230  CA  LEU A 161       4.853  24.148  43.686  1.00 20.28   A
ATOM   6231  CB  LEU A 161       5.580  22.902  44.207  1.00 20.48   A
ATOM   6232  CG  LEU A 161       5.015  21.562  43.713  1.00 20.77   A
ATOM   6233  CD1 LEU A 161       6.014  20.435  43.957  1.00 20.74   A
ATOM   6234  CD2 LEU A 161       3.700  21.283  44.419  1.00 20.80   A
ATOM   6235  C   LEU A 161       5.048  25.312  44.655  1.00 20.60   A
ATOM   6236  O   LEU A 161       4.329  25.426  45.651  1.00 20.50   A
ATOM   6237  N   VAL A 162       6.021  26.170  44.364  1.00 20.44   A
ATOM   6238  CA  VAL A 162       6.282  27.335  45.207  1.00 20.53   A
ATOM   6239  CB  VAL A 162       7.546  28.101  44.744  1.00 20.23   A
ATOM   6240  CG1 VAL A 162       7.622  29.466  45.434  1.00 20.06   A
ATOM   6241  CG2 VAL A 162       8.792  27.291  45.050  1.00 19.98   A
ATOM   6242  C   VAL A 162       5.097  28.290  45.150  1.00 21.05   A
ATOM   6243  O   VAL A 162       4.711  28.879  46.160  1.00 21.34   A
ATOM   6244  N   PHE A 163       4.524  28.452  43.963  1.00 21.34   A
ATOM   6245  CA  PHE A 163       3.395  29.356  43.785  1.00 21.75   A
ATOM   6246  CB  PHE A 163       3.517  30.080  42.448  1.00 21.81   A
ATOM   6247  CG  PHE A 163       4.798  30.832  42.290  1.00 22.12   A
ATOM   6248  CD1 PHE A 163       5.912  30.223  41.723  1.00 22.14   A
ATOM   6249  CD2 PHE A 163       4.904  32.147  42.735  1.00 22.21   A
ATOM   6250  CE1 PHE A 163       7.114  30.915  41.598  1.00 22.33   A
ATOM   6251  CE2 PHE A 163       6.103  32.845  42.615  1.00 22.06   A
ATOM   6252  CZ  PHE A 163       7.211  32.232  42.048  1.00 22.23   A
ATOM   6253  C   PHE A 163       2.035  28.679  43.866  1.00 21.93   A
ATOM   6254  O   PHE A 163       1.016  29.351  44.006  1.00 22.09   A
ATOM   6528  N   THR A 197      16.938  29.580  46.456  1.00 42.04   A
ATOM   6529  CA  THR A 197      16.335  30.780  45.882  1.00 42.10   A
ATOM   6530  CB  THR A 197      17.042  31.183  44.574  1.00 41.93   A
ATOM   6531  OG1 THR A 197      17.071  30.063  43.680  1.00 41.66   A
ATOM   6532  CG2 THR A 197      18.466  31.642  44.858  1.00 41.90   A
ATOM   6533  C   THR A 197      14.852  30.565  45.588  1.00 42.37   A
ATOM   6534  O   THR A 197      14.363  29.436  45.631  1.00 42.08   A
ATOM   6535  N   LYS A 198      14.140  31.649  45.288  1.00 42.36   A
ATOM   6536  CA  LYS A 198      12.712  31.566  44.992  1.00 42.71   A
ATOM   6537  CB  LYS A 198      12.052  32.947  45.102  1.00 42.62   A
ATOM   6538  CG  LYS A 198      10.532  32.914  44.946  1.00 42.36   A
ATOM   6539  CD  LYS A 198       9.902  34.305  44.974  1.00 42.26   A
ATOM   6540  CE  LYS A 198      10.279  35.121  43.746  1.00 42.29   A
ATOM   6541  NZ  LYS A 198       9.661  36.480  43.744  1.00 42.09   A
ATOM   6542  C   LYS A 198      12.451  30.995  43.599  1.00 42.44   A
ATOM   6543  O   LYS A 198      11.440  30.331  43.376  1.00 43.10   A
ATOM   6544  N   LEU A 199      13.359  31.257  42.664  1.00 42.38   A
ATOM   6545  CA  LEU A 199      13.208  30.762  41.302  1.00 41.31   A
ATOM   6546  CB  LEU A 199      13.021  31.929  40.328  1.00 41.79   A
ATOM   6547  CG  LEU A 199      11.826  32.851  40.580  1.00 41.74   A
ATOM   6548  CD1 LEU A 199      11.825  33.976  39.562  1.00 41.87   A
ATOM   6549  CD2 LEU A 199      10.537  32.054  40.500  1.00 41.99   A
ATOM   6550  C   LEU A 199      14.415  29.940  40.880  1.00 41.18   A
ATOM   6551  O   LEU A 199      15.357  29.815  41.690  1.00 40.87   A
ATOM   6552  OXT LEU A 199      14.404  29.431  39.740  1.00 40.62   A
ATOM   6613  N1  GSH H 200      14.652  30.753  26.106  1.00 31.06   H
ATOM   6614  CA1 GSH H 200      16.043  30.929  26.532  1.00 30.39   H
ATOM   6615  C1  GSH H 200      16.615  29.624  27.134  1.00 29.87   H
ATOM   6616  O11 GSH H 200      15.850  28.693  27.401  1.00 29.01   H
ATOM   6617  O12 GSH H 200      17.912  29.630  27.407  1.00 29.27   H
ATOM   6618  CB1 GSH H 200      16.079  32.017  27.617  1.00 30.85   H
ATOM   6619  CG1 GSH H 200      16.018  33.443  27.054  1.00 30.90   H
ATOM   6620  CD1 GSH H 200      15.735  34.381  28.252  1.00 30.62   H
ATOM   6621  OE1 GSH H 200      14.695  35.035  28.263  1.00 30.67   H
ATOM   6622  N2  GSH H 200      16.666  34.424  29.226  1.00 30.63   H
ATOM   6623  CA2 GSH H 200      16.479  35.316  30.387  1.00 30.99   H
ATOM   6624  C2  GSH H 200      17.327  36.467  30.245  1.00 31.16   H
ATOM   6625  O2  GSH H 200      18.505  36.372  29.874  1.00 30.98   H
ATOM   6626  CB2 GSH H 200      16.883  34.616  31.709  1.00 30.96   H
ATOM   6627  SG2 GSH H 200      15.567  33.583  32.426  1.00 31.20   H
ATOM   6628  N3  GSH H 200      16.793  37.649  30.634  1.00 31.83   H
ATOM   6629  CA3 GSH H 200      17.595  38.892  30.738  1.00 32.45   H
ATOM   6630  C3  GSH H 200      17.196  39.860  29.638  1.00 32.93   H
ATOM   6631  O31 GSH H 200      17.851  40.926  29.570  1.00 33.18   H
ATOM   6632  O32 GSH H 200      16.268  39.526  28.858  1.00 33.08   H
ATOM   6634 MG+2 MG2 M 902      10.400  26.589  23.001  1.00 23.91   M
ATOM   6641  OH2 WAT S   7      11.530  25.061  23.828  1.00 37.06   S
ATOM   6642  OH2 WAT S   8       9.540  27.210  24.684  1.00 24.57   S
ATOM   6643  OH2 WAT S   9       9.510  28.276  22.036  1.00 26.85   S
ATOM   6644  OH2 WAT S  10      11.074  26.182  21.146  1.00 25.39   S
ATOM   6645  OH2 WAT S  11       8.769  25.220  22.701  1.00 23.15   S
ATOM   6646  OH2 WAT S  12      12.343  27.736  23.214  1.00 21.75   S
ATOM   6655  OH2 WAT S  21      16.153  24.647  33.762  1.00 15.93   S
ATOM   6660  OH2 WAT S  26      22.016  34.735  24.315  1.00 19.54   S
ATOM   6690  OH2 WAT S  56      19.895  31.455  26.292  1.00 20.15   S
ATOM   6722  OH2 WAT S  88      15.099  33.768  23.429  1.00 20.21   S
ATOM   6746  OH2 WAT S 112      13.586  26.219  37.252  1.00 28.05   S
ATOM   6749  OH2 WAT S 115      29.682  31.074  30.423  1.00 32.25   S
ATOM   6757  OH2 WAT S 123      20.931  25.748  41.633  1.00 32.02   S
ATOM   6758  OH2 WAT S 124      17.734  33.757  22.543  1.00 19.10   S
ATOM   6770  OH2 WAT S 136      13.426  24.600  39.459  1.00 28.07   S
ATOM   6774  OH2 WAT S 140      16.050  26.391  24.708  1.00 22.82   S
ATOM   6782  OH2 WAT S 148      14.395  37.589  28.342  1.00 35.97   S
ATOM   6811  OH2 WAT S 177      19.958  32.909  23.887  1.00 18.07   S
ATOM   6829  OH2 WAT S 195      14.106  35.347  25.480  1.00 25.75   S
ATOM   6840  OH2 WAT S 206      14.044  35.490  20.956  1.00 20.11   S
ATOM   6928  OH2 WAT S 294      25.213  29.402  36.456  1.00 21.97   S
ATOM   6929  OH2 WAT S 295       4.780  29.656  25.498  1.00 28.39   S
ATOM   6940  OH2 WAT S 306      11.910  36.992  22.272  1.00 27.44   S
ATOM   7008  OH2 WAT S 374      19.731  28.119  43.144  1.00 34.76   S
ATOM   7079  OH2 WAT S 445       9.001  41.153  37.697  1.00 40.98   S
ATOM   7085  OH2 WAT S 451      14.312  39.335  22.120  1.00 52.27   S
ATOM   7095  OH2 WAT S 461      11.445  36.299  24.804  1.00 39.65   S
ATOM   7123  OH2 WAT S 489      11.366  30.498  26.166  1.00 37.93   S
ATOM   7129  OH2 WAT S 495      16.228  23.406  21.692  1.00 34.70   S
ATOM   7138  OH2 WAT S 504      21.673  36.938  40.112  1.00 39.58   S
ATOM   7140  OH2 WAT S 506       8.186  35.879  39.587  1.00 35.09   S
ATOM   7155  OH2 WAT S 521      17.208  36.485  21.785  1.00 33.85   S
ATOM   7179  OH2 WAT S 545       7.692  39.218  31.544  1.00 38.01   S
ATOM   7184  OH2 WAT S 550      16.301  40.121  43.773  1.00 42.74   S
ATOM   7205  OH2 WAT S 571      16.471  40.729  21.826  1.00 44.98   S
ATOM   7219  OH2 WAT S 585      12.552  26.597  33.929  1.00 43.65   S
ATOM   7229  OH2 WAT S 595      17.756  38.966  20.182  1.00 39.29   S
ATOM   7231  OH2 WAT S 597      13.596  27.392  25.614  1.00 33.67   S
ATOM   7235  OH2 WAT S 601       8.227  29.798  24.106  1.00 42.88   S
ATOM   7250  OH2 WAT S 616      12.430  28.404  38.196  1.00 28.06   S
ATOM   7302  OH2 WAT S 668       8.268  32.489  24.271  1.00 34.58   S
ATOM   7306  OH2 WAT S 672      13.738  43.695  22.850  1.00 40.33   S
ATOM   7350  OH2 WAT S 716      16.122  38.680  37.510  1.00 37.39   S
ATOM   7351  OH2 WAT S 717      12.657  31.864  34.383  1.00 37.30   S
ATOM   7362  OH2 WAT S 728      24.227  34.662  22.649  1.00 33.80   S
ATOM   7363  OH2 WAT S 729      25.788  32.632  21.734  1.00 31.91   S
ATOM   7398  OH2 WAT S 764      15.402  25.563  30.917  1.00 22.67   S
ATOM   7399  OH2 WAT S 765      13.051  32.782  31.072  1.00 31.89   S
ATOM   7400  OH2 WAT S 766      10.600  32.486  30.037  1.00 38.06   S
ATOM   7453  OH2 WAT S 818      10.407  33.035  26.315  1.00 34.27   S
ATOM   7454  OH2 WAT S 819       4.103  39.433  24.839  1.00 35.58   S
ATOM   7455  OH2 WAT S 820       8.800  40.482  25.686  1.00 38.38   S
ATOM   7466  OH2 WAT S 831      22.905  42.140  23.725  1.00 34.87   S
ATOM   7523  OH2 WAT S 890      11.498  40.681  41.811  1.00 34.74   S
ATOM   7533  OH2 WAT S 901      21.231  36.504  45.050  1.00 40.93   S
ATOM   7540  OH2 WAT S 908      16.196  42.111  32.687  1.00 37.19   S
ATOM   7588  OH2 WAT S1234      13.747  22.487  22.995  1.00 32.97   S
【００４９】
【表３】
ヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２α（Ｕ４６）との複合体の３次元構造座標
ATOM   4966  N   TYR A   8      -2.271  -4.196  32.836  1.00 14.93   A
ATOM   4967  CA  TYR A   8      -0.858  -4.474  33.097  1.00 15.12   A
ATOM   4968  CB  TYR A   8      -0.097  -3.155  33.272  1.00 14.72   A
ATOM   4969  CG  TYR A   8       1.411  -3.302  33.334  1.00 14.32   A
ATOM   4970  CD1 TYR A   8       2.128  -3.846  32.262  1.00 13.92   A
ATOM   4971  CE1 TYR A   8       3.518  -3.985  32.321  1.00 13.52   A
ATOM   4972  CD2 TYR A   8       2.125  -2.898  34.469  1.00 14.03   A
ATOM   4973  CE2 TYR A   8       3.508  -3.032  34.539  1.00 13.52   A
ATOM   4974  CZ  TYR A   8       4.199  -3.577  33.461  1.00 13.52   A
ATOM   4975  OH  TYR A   8       5.563  -3.718  33.529  1.00 13.03   A
ATOM   4976  C   TYR A   8      -0.758  -5.293  34.384  1.00 15.52   A
ATOM   4977  O   TYR A   8      -1.775  -5.603  35.002  1.00 15.35   A
ATOM   4978  N   PHE A   9       0.460  -5.652  34.782  1.00 15.96   A
ATOM   4979  CA  PHE A   9       0.654  -6.400  36.021  1.00 16.41   A
ATOM   4980  CB  PHE A   9       2.049  -7.029  36.071  1.00 16.62   A
ATOM   4981  CG  PHE A   9       2.240  -8.149  35.092  1.00 17.03   A
ATOM   4982  CD1 PHE A   9       3.165  -8.035  34.055  1.00 17.22   A
ATOM   4983  CD2 PHE A   9       1.497  -9.322  35.209  1.00 17.29   A
ATOM   4984  CE1 PHE A   9       3.352  -9.072  33.143  1.00 17.28   A
ATOM   4985  CE2 PHE A   9       1.671 -10.371  34.304  1.00 17.39   A
ATOM   4986  CZ  PHE A   9       2.603 -10.245  33.267  1.00 17.64   A
ATOM   4987  C   PHE A   9       0.495  -5.427  37.187  1.00 16.51   A
ATOM   4988  O   PHE A   9       0.380  -4.220  36.975  1.00 16.43   A
ATOM   4989  N   ASN A  10       0.485  -5.951  38.410  1.00 16.68   A
ATOM   4990  CA  ASN A  10       0.345  -5.114  39.595  1.00 17.13   A
ATOM   4991  CB  ASN A  10      -0.235  -5.911  40.765  1.00 17.62   A
ATOM   4992  CG  ASN A  10      -0.251  -5.111  42.053  1.00 18.18   A
ATOM   4993  OD1 ASN A  10      -0.602  -3.927  42.060  1.00 18.91   A
ATOM   4994  ND2 ASN A  10       0.120  -5.751  43.151  1.00 18.74   A
ATOM   4995  C   ASN A  10       1.695  -4.539  39.996  1.00 17.08   A
ATOM   4996  O   ASN A  10       2.278  -4.934  41.002  1.00 17.04   A
ATOM   4997  N   MET A  11       2.189  -3.607  39.189  1.00 16.98   A
ATOM   4998  CA  MET A  11       3.467  -2.962  39.448  1.00 16.70   A
ATOM   4999  CB  MET A  11       4.626  -3.927  39.141  1.00 17.68   A
ATOM   5000  CG  MET A  11       4.630  -4.530  37.748  1.00 18.92   A
ATOM   5001  SD  MET A  11       6.178  -5.456  37.353  1.00 20.84   A
ATOM   5002  CE  MET A  11       5.595  -7.137  37.373  1.00 19.96   A
ATOM   5003  C   MET A  11       3.561  -1.708  38.587  1.00 15.92   A
ATOM   5004  O   MET A  11       2.740  -1.512  37.702  1.00 15.49   A
ATOM   5005  N   ARG A  12       4.531  -0.842  38.872  1.00 15.17   A
ATOM   5006  CA  ARG A  12       4.697   0.372  38.084  1.00 14.70   A
ATOM   5007  CB  ARG A  12       5.759   1.285  38.704  1.00 14.69   A
ATOM   5008  CG  ARG A  12       5.418   1.777  40.110  1.00 15.00   A
ATOM   5009  CD  ARG A  12       6.413   2.825  40.594  1.00 14.97   A
ATOM   5010  NE  ARG A  12       7.785   2.323  40.634  1.00 15.22   A
ATOM   5011  CZ  ARG A  12       8.265   1.490  41.556  1.00 15.45   A
ATOM   5012  NH1 ARG A  12       7.485   1.052  42.536  1.00 15.40   A
ATOM   5013  NH2 ARG A  12       9.533   1.096  41.502  1.00 15.26   A
ATOM   5014  C   ARG A  12       5.136  -0.069  36.695  1.00 14.31   A
ATOM   5015  O   ARG A  12       4.432   0.147  35.710  1.00 13.90   A
ATOM   5016  N   GLY A  13       6.301  -0.708  36.639  1.00 13.97   A
ATOM   5017  CA  GLY A  13       6.837  -1.202  35.388  1.00 13.65   A
ATOM   5018  C   GLY A  13       6.705  -0.260  34.207  1.00 13.50   A
ATOM   5019  O   GLY A  13       6.938   0.941  34.321  1.00 13.35   A
ATOM   5020  N   ARG A  14       6.309  -0.816  33.070  1.00 13.31   A
ATOM   5021  CA  ARG A  14       6.179  -0.047  31.848  1.00 13.30   A
ATOM   5022  CB  ARG A  14       6.431  -0.959  30.650  1.00 14.32   A
ATOM   5023  CG  ARG A  14       7.877  -1.395  30.542  1.00 16.00   A
ATOM   5024  CD  ARG A  14       8.117  -2.259  29.325  1.00 17.28   A
ATOM   5025  NE  ARG A  14       9.532  -2.265  28.979  1.00 18.88   A
ATOM   5026  CZ  ARG A  14      10.134  -1.329  28.246  1.00 19.26   A
ATOM   5027  NH1 ARG A  14       9.444  -0.304  27.762  1.00 19.28   A
ATOM   5028  NH2 ARG A  14      11.442  -1.408  28.014  1.00 20.21   A
ATOM   5029  C   ARG A  14       4.859   0.689  31.669  1.00 12.77   A
ATOM   5030  O   ARG A  14       4.696   1.435  30.710  1.00 12.75   A
ATOM   5031  N   ALA A  15       3.920   0.496  32.590  1.00 12.21   A
ATOM   5032  CA  ALA A  15       2.624   1.159  32.493  1.00 11.48   A
ATOM   5033  CB  ALA A  15       1.531   0.245  33.019  1.00 11.52   A
ATOM   5034  C   ALA A  15       2.596   2.464  33.261  1.00 10.95   A
ATOM   5035  O   ALA A  15       1.780   3.352  32.977  1.00 10.86   A
ATOM   5036  N   GLU A  16       3.490   2.580  34.238  1.00 10.32   A
ATOM   5037  CA  GLU A  16       3.546   3.771  35.087  1.00  9.76   A
ATOM   5038  CB  GLU A  16       4.748   3.677  36.036  1.00  9.29   A
ATOM   5039  CG  GLU A  16       4.648   4.565  37.277  1.00  8.91   A
ATOM   5040  CD  GLU A  16       3.485   4.192  38.189  1.00  8.41   A
ATOM   5041  OE1 GLU A  16       2.858   3.134  37.983  1.00  8.43   A
ATOM   5042  OE2 GLU A  16       3.199   4.960  39.125  1.00  8.51   A
ATOM   5043  C   GLU A  16       3.590   5.084  34.303  1.00  9.64   A
ATOM   5044  O   GLU A  16       2.999   6.071  34.730  1.00  9.63   A
ATOM   5045  N   ILE A  17       4.287   5.096  33.166  1.00  9.45   A
ATOM   5046  CA  ILE A  17       4.377   6.312  32.368  1.00  9.29   A
ATOM   5047  CB  ILE A  17       5.333   6.139  31.150  1.00  9.25   A
ATOM   5048  CG2 ILE A  17       4.867   5.015  30.251  1.00  9.64   A
ATOM   5049  CG1 ILE A  17       5.413   7.442  30.358  1.00  9.55   A
ATOM   5050  CD1 ILE A  17       5.988   8.596  31.168  1.00  9.78   A
ATOM   5051  C   ILE A  17       2.984   6.717  31.892  1.00  9.19   A
ATOM   5052  O   ILE A  17       2.648   7.897  31.845  1.00  8.98   A
ATOM   5242  N   TRP A  39      -2.591 -14.181  33.457  1.00 37.71   A
ATOM   5243  CA  TRP A  39      -1.830 -13.655  32.329  1.00 37.46   A
ATOM   5244  CB  TRP A  39      -0.376 -13.394  32.737  1.00 37.38   A
ATOM   5245  CG  TRP A  39       0.495 -12.956  31.594  1.00 37.31   A
ATOM   5246  CD2 TRP A  39       0.174 -11.987  30.583  1.00 37.22   A
ATOM   5247  CE2 TRP A  39       1.277 -11.918  29.704  1.00 37.19   A
ATOM   5248  CE3 TRP A  39      -0.940 -11.171  30.336  1.00 37.22   A
ATOM   5249  CD1 TRP A  39       1.745 -13.416  31.295  1.00 37.27   A
ATOM   5250  NE1 TRP A  39       2.220 -12.801  30.160  1.00 37.23   A
ATOM   5251  CZ2 TRP A  39       1.300 -11.068  28.594  1.00 37.19   A
ATOM   5252  CZ3 TRP A  39      -0.916 -10.323  29.230  1.00 37.17   A
ATOM   5253  CH2 TRP A  39       0.198 -10.281  28.374  1.00 37.16   A
ATOM   5254  C   TRP A  39      -1.866 -14.602  31.124  1.00 37.40   A
ATOM   5255  O   TRP A  39      -2.138 -14.177  30.003  1.00 37.29   A
ATOM   5256  N   PRO A  40      -1.597 -15.901  31.342  1.00 37.35   A
ATOM   5257  CD  PRO A  40      -1.235 -16.548  32.616  1.00 37.43   A
ATOM   5258  CA  PRO A  40      -1.605 -16.881  30.251  1.00 37.26   A
ATOM   5259  CB  PRO A  40      -1.489 -18.212  30.987  1.00 37.31   A
ATOM   5260  CG  PRO A  40      -0.618 -17.854  32.153  1.00 37.40   A
ATOM   5261  C   PRO A  40      -2.843 -16.817  29.363  1.00 37.11   A
ATOM   5262  O   PRO A  40      -2.739 -16.888  28.139  1.00 37.23   A
ATOM   5263  N   GLU A  41      -4.011 -16.677  29.981  1.00 36.89   A
ATOM   5264  CA  GLU A  41      -5.265 -16.614  29.236  1.00 36.63   A
ATOM   5265  CB  GLU A  41      -6.457 -16.755  30.188  1.00 37.02   A
ATOM   5266  CG  GLU A  41      -7.757 -17.156  29.501  1.00 37.64   A
ATOM   5267  CD  GLU A  41      -7.734 -18.601  29.023  1.00 38.10   A
ATOM   5268  OE1 GLU A  41      -8.709 -19.033  28.364  1.00 38.32   A
ATOM   5269  OE2 GLU A  41      -6.741 -19.307  29.311  1.00 38.26   A
ATOM   5270  C   GLU A  41      -5.381 -15.297  28.474  1.00 36.10   A
ATOM   5271  O   GLU A  41      -5.703 -15.281  27.285  1.00 36.26   A
ATOM   5272  N   ILE A  42      -5.120 -14.194  29.166  1.00 35.28   A
ATOM   5273  CA  ILE A  42      -5.204 -12.874  28.553  1.00 34.47   A
ATOM   5274  CB  ILE A  42      -4.980 -11.773  29.597  1.00 34.57   A
ATOM   5275  CG2 ILE A  42      -5.152 -10.406  28.953  1.00 34.48   A
ATOM   5276  CG1 ILE A  42      -5.968 -11.952  30.750  1.00 34.54   A
ATOM   5277  CD1 ILE A  42      -5.687 -11.076  31.944  1.00 34.74   A
ATOM   5278  C   ILE A  42      -4.173 -12.715  27.441  1.00 33.83   A
ATOM   5279  O   ILE A  42      -4.466 -12.161  26.384  1.00 33.69   A
ATOM   5280  N   LYS A  43      -2.968 -13.213  27.691  1.00 33.07   A
ATOM   5281  CA  LYS A  43      -1.879 -13.133  26.729  1.00 32.30   A
ATOM   5282  CB  LYS A  43      -0.664 -13.899  27.258  1.00 32.18   A
ATOM   5283  CG  LYS A  43       0.536 -13.883  26.324  1.00 32.18   A
ATOM   5284  CD  LYS A  43       1.622 -14.833  26.798  1.00 32.02   A
ATOM   5285  CE  LYS A  43       2.795 -14.865  25.831  1.00 31.99   A
ATOM   5286  NZ  LYS A  43       3.484 -13.542  25.723  1.00 31.70   A
ATOM   5287  C   LYS A  43      -2.267 -13.674  25.354  1.00 31.74   A
ATOM   5288  O   LYS A  43      -2.038 -13.022  24.333  1.00 31.67   A
ATOM   5328  N   GLY A  49       0.717 -10.483  22.236  1.00 21.45   A
ATOM   5329  CA  GLY A  49       0.900 -11.142  23.516  1.00 20.85   A
ATOM   5330  C   GLY A  49       1.735 -10.433  24.567  1.00 20.53   A
ATOM   5331  O   GLY A  49       2.506 -11.072  25.276  1.00 20.53   A
ATOM   5332  N   LYS A  50       1.590  -9.120  24.688  1.00 20.06   A
ATOM   5333  CA  LYS A  50       2.354  -8.390  25.686  1.00 19.66   A
ATOM   5334  CB  LYS A  50       3.683  -7.916  25.085  1.00 19.97   A
ATOM   5335  CG  LYS A  50       4.636  -9.061  24.812  1.00 20.63   A
ATOM   5336  CD  LYS A  50       5.846  -8.644  24.024  1.00 21.03   A
ATOM   5337  CE  LYS A  50       6.699  -9.864  23.706  1.00 21.10   A
ATOM   5338  NZ  LYS A  50       5.873 -10.927  23.044  1.00 21.21   A
ATOM   5339  C   LYS A  50       1.601  -7.206  26.271  1.00 19.21   A
ATOM   5340  O   LYS A  50       0.713  -6.633  25.636  1.00 18.74   A
ATOM   5341  N   ILE A  51       1.963  -6.852  27.497  1.00 18.42   A
ATOM   5342  CA  ILE A  51       1.354  -5.720  28.162  1.00 18.05   A
ATOM   5343  CB  ILE A  51       0.574  -6.149  29.414  1.00 18.14   A
ATOM   5344  CG2 ILE A  51      -0.755  -6.739  29.010  1.00 17.97   A
ATOM   5345  CG1 ILE A  51       1.404  -7.128  30.246  1.00 18.34   A
ATOM   5346  CD1 ILE A  51       0.681  -7.613  31.494  1.00 18.26   A
ATOM   5347  C   ILE A  51       2.424  -4.699  28.538  1.00 17.67   A
ATOM   5348  O   ILE A  51       3.618  -5.012  28.572  1.00 17.72   A
ATOM   5349  N   PRO A  52       2.002  -3.473  28.874  1.00 17.15   A
ATOM   5350  CD  PRO A  52       2.906  -2.369  29.239  1.00 17.33   A
ATOM   5351  CA  PRO A  52       0.610  -3.021  28.909  1.00 16.82   A
ATOM   5352  CB  PRO A  52       0.703  -1.736  29.713  1.00 16.81   A
ATOM   5353  CG  PRO A  52       1.968  -1.159  29.205  1.00 16.96   A
ATOM   5354  C   PRO A  52      -0.093  -2.777  27.584  1.00 16.60   A
ATOM   5355  O   PRO A  52       0.526  -2.674  26.526  1.00 16.29   A
ATOM   5356  N   ILE A  53      -1.411  -2.678  27.672  1.00 16.36   A
ATOM   5357  CA  ILE A  53      -2.233  -2.361  26.522  1.00 16.17   A
ATOM   5358  CB  ILE A  53      -2.992  -3.587  25.980  1.00 16.14   A
ATOM   5359  CG2 ILE A  53      -2.000  -4.620  25.440  1.00 16.39   A
ATOM   5360  CG1 ILE A  53      -3.875  -4.184  27.071  1.00 16.34   A
ATOM   5361  CD1 ILE A  53      -4.859  -5.218  26.544  1.00 16.22   A
ATOM   5362  C   ILE A  53      -3.235  -1.325  27.015  1.00 15.98   A
ATOM   5363  O   ILE A  53      -3.563  -1.277  28.202  1.00 15.70   A
ATOM   5423  N   HIS A  62      -1.249  -1.093  22.011  1.00 11.78   A
ATOM   5424  CA  HIS A  62      -0.158  -1.730  22.757  1.00 11.13   A
ATOM   5425  CB  HIS A  62       0.120  -3.150  22.240  1.00 11.01   A
ATOM   5426  CG  HIS A  62       0.673  -3.202  20.848  1.00 10.84   A
ATOM   5427  CD2 HIS A  62       1.903  -3.533  20.392  1.00 10.56   A
ATOM   5428  ND1 HIS A  62      -0.087  -2.926  19.732  1.00 10.84   A
ATOM   5429  CE1 HIS A  62       0.650  -3.090  18.648  1.00 10.55   A
ATOM   5430  NE2 HIS A  62       1.861  -3.458  19.021  1.00 10.75   A
ATOM   5431  C   HIS A  62       1.112  -0.882  22.665  1.00 10.62   A
ATOM   5432  O   HIS A  62       1.118   0.155  21.996  1.00 10.80   A
ATOM   5433  N   GLN A  63       2.176  -1.337  23.332  1.00 10.07   A
ATOM   5434  CA  GLN A  63       3.465  -0.641  23.377  1.00  9.39   A
ATOM   5435  CB  GLN A  63       3.957  -0.289  21.969  1.00  9.20   A
ATOM   5436  CG  GLN A  63       4.702  -1.417  21.248  1.00  8.99   A
ATOM   5437  CD  GLN A  63       5.911  -1.932  22.027  1.00  8.95   A
ATOM   5438  OE1 GLN A  63       6.481  -1.220  22.858  1.00  8.52   A
ATOM   5439  NE2 GLN A  63       6.315  -3.165  21.745  1.00  8.76   A
ATOM   5440  C   GLN A  63       3.324   0.618  24.223  1.00  8.90   A
ATOM   5441  O   GLN A  63       2.781   1.629  23.769  1.00  9.08   A
ATOM   5442  N   SER A  64       3.830   0.554  25.452  1.00  8.48   A
ATOM   5443  CA  SER A  64       3.708   1.668  26.396  1.00  8.06   A
ATOM   5444  CB  SER A  64       4.440   1.342  27.706  1.00  7.67   A
ATOM   5445  OG  SER A  64       5.839   1.246  27.528  1.00  8.18   A
ATOM   5446  C   SER A  64       4.143   3.045  25.902  1.00  7.75   A
ATOM   5447  O   SER A  64       3.447   4.032  26.141  1.00  7.74   A
ATOM   5448  N   LEU A  65       5.284   3.126  25.225  1.00  7.75   A
ATOM   5449  CA  LEU A  65       5.754   4.424  24.752  1.00  7.47   A
ATOM   5450  CB  LEU A  65       7.224   4.346  24.359  1.00  7.66   A
ATOM   5451  CG  LEU A  65       8.162   3.849  25.461  1.00  7.74   A
ATOM   5452  CD1 LEU A  65       9.591   4.192  25.062  1.00  7.25   A
ATOM   5453  CD2 LEU A  65       7.820   4.516  26.812  1.00  7.33   A
ATOM   5454  C   LEU A  65       4.928   4.945  23.586  1.00  7.33   A
ATOM   5455  O   LEU A  65       4.768   6.151  23.426  1.00  7.33   A
ATOM   5662  N   ASP A  93      13.523   7.274  24.597  1.00  7.43   A
ATOM   5663  CA  ASP A  93      14.133   6.074  24.039  1.00  7.59   A
ATOM   5664  CB  ASP A  93      14.267   6.190  22.520  1.00  7.58   A
ATOM   5665  CG  ASP A  93      12.964   5.867  21.793  1.00  7.82   A
ATOM   5666  OD1 ASP A  93      12.977   5.837  20.550  1.00  8.49   A
ATOM   5667  OD2 ASP A  93      11.937   5.640  22.466  1.00  7.73   A
ATOM   5668  C   ASP A  93      15.494   5.763  24.674  1.00  7.65   A
ATOM   5669  O   ASP A  93      15.839   4.597  24.858  1.00  8.00   A
ATOM   5670  N   THR A  94      16.259   6.800  25.009  1.00  7.91   A
ATOM   5671  CA  THR A  94      17.561   6.608  25.646  1.00  8.08   A
ATOM   5672  CB  THR A  94      18.281   7.963  25.879  1.00  8.13   A
ATOM   5673  OG1 THR A  94      18.619   8.547  24.617  1.00  8.31   A
ATOM   5674  CG2 THR A  94      19.557   7.772  26.701  1.00  8.08   A
ATOM   5675  C   THR A  94      17.361   5.905  26.993  1.00  8.54   A
ATOM   5676  O   THR A  94      18.046   4.925  27.308  1.00  8.42   A
ATOM   5677  N   LEU A  95      16.424   6.410  27.788  1.00  8.76   A
ATOM   5678  CA  LEU A  95      16.137   5.804  29.079  1.00  9.53   A
ATOM   5679  CB  LEU A  95      15.107   6.642  29.851  1.00  9.33   A
ATOM   5680  CG  LEU A  95      15.647   7.972  30.383  1.00  9.50   A
ATOM   5681  CD1 LEU A  95      14.517   8.827  30.949  1.00  9.22   A
ATOM   5682  CD2 LEU A  95      16.694   7.684  31.453  1.00  9.41   A
ATOM   5683  C   LEU A  95      15.618   4.377  28.879  1.00  9.79   A
ATOM   5684  O   LEU A  95      16.055   3.460  29.566  1.00  9.96   A
ATOM   5685  N   ASP A  96      14.709   4.200  27.920  1.00 10.44   A
ATOM   5686  CA  ASP A  96      14.123   2.896  27.626  1.00 11.05   A
ATOM   5687  CB  ASP A  96      13.062   3.027  26.529  1.00 11.36   A
ATOM   5688  CG  ASP A  96      12.107   1.841  26.499  1.00 11.78   A
ATOM   5689  OD1 ASP A  96      11.640   1.431  27.579  1.00 12.41   A
ATOM   5690  OD2 ASP A  96      11.806   1.334  25.409  1.00 12.03   A
ATOM   5691  C   ASP A  96      15.182   1.876  27.201  1.00 11.34   A
ATOM   5692  O   ASP A  96      15.169   0.734  27.650  1.00 11.33   A
ATOM   5693  N   ASP A  97      16.092   2.294  26.329  1.00 11.73   A
ATOM   5694  CA  ASP A  97      17.154   1.412  25.875  1.00 12.14   A
ATOM   5695  CB  ASP A  97      18.136   2.154  24.963  1.00 11.82   A
ATOM   5696  CG  ASP A  97      17.599   2.373  23.544  1.00 11.92   A
ATOM   5697  OD1 ASP A  97      18.280   3.083  22.784  1.00 11.78   A
ATOM   5698  OD2 ASP A  97      16.524   1.840  23.187  1.00 11.79   A
ATOM   5699  C   ASP A  97      17.924   0.865  27.084  1.00 12.59   A
ATOM   5700  O   ASP A  97      18.228  -0.326  27.150  1.00 12.62   A
ATOM   5701  N   PHE A  98      18.242   1.731  28.041  1.00 13.02   A
ATOM   5702  CA  PHE A  98      18.992   1.296  29.219  1.00 13.80   A
ATOM   5703  CB  PHE A  98      19.449   2.500  30.047  1.00 13.80   A
ATOM   5704  CG  PHE A  98      20.332   2.127  31.203  1.00 14.07   A
ATOM   5705  CD1 PHE A  98      21.550   1.488  30.990  1.00 14.20   A
ATOM   5706  CD2 PHE A  98      19.937   2.391  32.507  1.00 14.15   A
ATOM   5707  CE1 PHE A  98      22.358   1.115  32.064  1.00 14.32   A
ATOM   5708  CE2 PHE A  98      20.736   2.022  33.583  1.00 14.28   A
ATOM   5709  CZ  PHE A  98      21.948   1.384  33.361  1.00 14.12   A
ATOM   5710  C   PHE A  98      18.209   0.335  30.112  1.00 14.33   A
ATOM   5711  O   PHE A  98      18.705  -0.739  30.467  1.00 14.62   A
ATOM   5712  N   MET A  99      16.992   0.722  30.482  1.00 14.73   A
ATOM   5713  CA  MET A  99      16.158  -0.120  31.329  1.00 15.34   A
ATOM   5714  CB  MET A  99      14.798   0.546  31.574  1.00 15.08   A
ATOM   5715  CG  MET A  99      14.878   1.932  32.202  1.00 14.94   A
ATOM   5716  SD  MET A  99      15.699   1.910  33.803  1.00 14.67   A
ATOM   5717  CE  MET A  99      14.395   1.275  34.807  1.00 14.69   A
ATOM   5718  C   MET A  99      15.938  -1.489  30.691  1.00 16.11   A
ATOM   5719  O   MET A  99      15.882  -2.504  31.387  1.00 15.98   A
ATOM   5720  N   SER A 100      15.811  -1.516  29.366  1.00 16.74   A
ATOM   5721  CA  SER A 100      15.576  -2.767  28.656  1.00 17.44   A
ATOM   5722  CB  SER A 100      15.116  -2.479  27.225  1.00 17.47   A
ATOM   5723  OG  SER A 100      13.823  -1.884  27.234  1.00 17.51   A
ATOM   5724  C   SER A 100      16.797  -3.681  28.656  1.00 18.04   A
ATOM   5725  O   SER A 100      16.674  -4.888  28.436  1.00 18.07   A
ATOM   5726  N   CYS A 101      17.972  -3.111  28.912  1.00 18.65   A
ATOM   5727  CA  CYS A 101      19.196  -3.905  28.964  1.00 19.36   A
ATOM   5728  CB  CYS A 101      20.428  -3.006  29.108  1.00 19.22   A
ATOM   5729  SG  CYS A 101      20.898  -2.082  27.630  1.00 20.13   A
ATOM   5730  C   CYS A 101      19.167  -4.889  30.134  1.00 19.75   A
ATOM   5731  O   CYS A 101      19.772  -5.950  30.059  1.00 19.91   A
ATOM   5732  N   PHE A 102      18.482  -4.533  31.218  1.00 20.31   A
ATOM   5733  CA  PHE A 102      18.410  -5.420  32.376  1.00 21.09   A
ATOM   5734  CB  PHE A 102      17.826  -4.693  33.594  1.00 20.83   A
ATOM   5735  CG  PHE A 102      18.672  -3.551  34.087  1.00 20.72   A
ATOM   5736  CD1 PHE A 102      18.775  -2.376  33.344  1.00 20.56   A
ATOM   5737  CD2 PHE A 102      19.374  -3.652  35.290  1.00 20.64   A
ATOM   5738  CE1 PHE A 102      19.565  -1.313  33.788  1.00 20.64   A
ATOM   5739  CE2 PHE A 102      20.170  -2.597  35.750  1.00 20.52   A
ATOM   5740  CZ  PHE A 102      20.267  -1.423  34.996  1.00 20.66   A
ATOM   5741  C   PHE A 102      17.554  -6.645  32.060  1.00 21.79   A
ATOM   5742  O   PHE A 102      16.490  -6.525  31.456  1.00 21.62   A
ATOM   5743  N   PRO A 103      18.024  -7.844  32.450  1.00 22.58   A
ATOM   5744  CD  PRO A 103      19.392  -8.117  32.928  1.00 22.84   A
ATOM   5745  CA  PRO A 103      17.297  -9.098  32.211  1.00 23.41   A
ATOM   5746  CB  PRO A 103      18.415 -10.133  32.185  1.00 23.19   A
ATOM   5747  CG  PRO A 103      19.353  -9.611  33.222  1.00 23.10   A
ATOM   5748  C   PRO A 103      16.272  -9.366  33.321  1.00 24.25   A
ATOM   5749  O   PRO A 103      16.459 -10.248  34.160  1.00 24.19   A
ATOM   5750  N   TRP A 104      15.191  -8.594  33.313  1.00 25.16   A
ATOM   5751  CA  TRP A 104      14.142  -8.722  34.313  1.00 26.25   A
ATOM   5752  CB  TRP A 104      13.049  -7.673  34.072  1.00 25.95   A
ATOM   5753  CG  TRP A 104      13.551  -6.261  33.946  1.00 25.64   A
ATOM   5754  CD2 TRP A 104      13.907  -5.375  35.016  1.00 25.47   A
ATOM   5755  CE2 TRP A 104      14.332  -4.162  34.429  1.00 25.40   A
ATOM   5756  CE3 TRP A 104      13.909  -5.488  36.412  1.00 25.27   A
ATOM   5757  CD1 TRP A 104      13.770  -5.568  32.788  1.00 25.58   A
ATOM   5758  NE1 TRP A 104      14.237  -4.307  33.070  1.00 25.45   A
ATOM   5759  CZ2 TRP A 104      14.757  -3.067  35.193  1.00 25.38   A
ATOM   5760  CZ3 TRP A 104      14.331  -4.398  37.173  1.00 25.16   A
ATOM   5761  CH2 TRP A 104      14.749  -3.205  36.560  1.00 25.21   A
ATOM   5762  C   TRP A 104      13.511 -10.115  34.334  1.00 27.21   A
ATOM   5763  O   TRP A 104      13.078 -10.597  35.383  1.00 27.22   A
ATOM   5764  N   ALA A 105      13.472 -10.763  33.175  1.00 28.32   A
ATOM   5765  CA  ALA A 105      12.872 -12.087  33.058  1.00 29.49   A
ATOM   5766  CB  ALA A 105      12.207 -12.226  31.697  1.00 29.48   A
ATOM   5767  C   ALA A 105      13.853 -13.233  33.270  1.00 30.44   A
ATOM   5768  O   ALA A 105      13.445 -14.391  33.354  1.00 30.58   A
ATOM   5769  N   GLU A 106      15.140 -12.917  33.369  1.00 31.43   A
ATOM   5770  CA  GLU A 106      16.147 -13.954  33.552  1.00 32.55   A
ATOM   5771  CB  GLU A 106      17.545 -13.338  33.620  1.00 32.51   A
ATOM   5772  CG  GLU A 106      18.634 -14.386  33.634  1.00 32.51   A
ATOM   5773  CD  GLU A 106      18.498 -15.352  32.472  1.00 32.54   A
ATOM   5774  OE1 GLU A 106      18.761 -16.555  32.662  1.00 32.34   A
ATOM   5775  OE2 GLU A 106      18.129 -14.905  31.365  1.00 32.59   A
ATOM   5776  C   GLU A 106      15.913 -14.809  34.791  1.00 33.37   A
ATOM   5777  O   GLU A 106      15.830 -14.294  35.908  1.00 33.46   A
ATOM   5778  N   LYS A 107      15.813 -16.121  34.588  1.00 34.40   A
ATOM   5779  CA  LYS A 107      15.592 -17.048  35.695  1.00 35.40   A
ATOM   5780  CB  LYS A 107      14.830 -18.287  35.212  1.00 35.45   A
ATOM   5781  CG  LYS A 107      13.486 -17.992  34.553  1.00 35.72   A
ATOM   5782  CD  LYS A 107      12.523 -17.293  35.497  1.00 35.84   A
ATOM   5783  CE  LYS A 107      12.103 -18.197  36.639  1.00 36.12   A
ATOM   5784  NZ  LYS A 107      11.273 -17.459  37.636  1.00 36.20   A
ATOM   5785  C   LYS A 107      16.915 -17.471  36.336  1.00 36.00   A
ATOM   5786  O   LYS A 107      16.947 -17.902  37.490  1.00 36.10   A
ATOM   5787  N   LYS A 108      18.003 -17.346  35.584  1.00 36.66   A
ATOM   5788  CA  LYS A 108      19.325 -17.698  36.088  1.00 37.40   A
ATOM   5789  CB  LYS A 108      20.295 -17.894  34.923  1.00 37.54   A
ATOM   5790  CG  LYS A 108      19.855 -18.959  33.941  1.00 37.73   A
ATOM   5791  CD  LYS A 108      20.783 -19.026  32.748  1.00 37.95   A
ATOM   5792  CE  LYS A 108      20.335 -20.101  31.781  1.00 38.07   A
ATOM   5793  NZ  LYS A 108      21.226 -20.180  30.593  1.00 38.35   A
ATOM   5794  C   LYS A 108      19.824 -16.576  36.992  1.00 37.85   A
ATOM   5795  O   LYS A 108      20.361 -15.575  36.514  1.00 37.87   A
ATOM   5796  N   GLN A 109      19.650 -16.751  38.298  1.00 38.38   A
ATOM   5797  CA  GLN A 109      20.057 -15.742  39.274  1.00 38.89   A
ATOM   5798  CB  GLN A 109      19.893 -16.287  40.696  1.00 39.27   A
ATOM   5799  CG  GLN A 109      19.103 -15.372  41.621  1.00 39.77   A
ATOM   5800  CD  GLN A 109      17.631 -15.280  41.236  1.00 40.04   A
ATOM   5801  OE1 GLN A 109      16.878 -14.472  41.791  1.00 40.13   A
ATOM   5802  NE2 GLN A 109      17.214 -16.116  40.287  1.00 40.11   A
ATOM   5803  C   GLN A 109      21.491 -15.264  39.081  1.00 38.96   A
ATOM   5804  O   GLN A 109      21.755 -14.061  39.052  1.00 39.02   A
ATOM   5805  N   ASP A 110      22.413 -16.211  38.951  1.00 39.02   A
ATOM   5806  CA  ASP A 110      23.826 -15.890  38.773  1.00 39.02   A
ATOM   5807  CB  ASP A 110      24.631 -17.178  38.608  1.00 39.32   A
ATOM   5808  CG  ASP A 110      24.226 -17.956  37.375  1.00 39.50   A
ATOM   5809  OD1 ASP A 110      23.005 -18.097  37.141  1.00 39.58   A
ATOM   5810  OD2 ASP A 110      25.124 -18.429  36.648  1.00 39.67   A
ATOM   5811  C   ASP A 110      24.061 -14.977  37.571  1.00 38.89   A
ATOM   5812  O   ASP A 110      24.802 -13.999  37.663  1.00 38.88   A
ATOM   5813  N   VAL A 111      23.433 -15.302  36.445  1.00 38.64   A
ATOM   5814  CA  VAL A 111      23.581 -14.507  35.231  1.00 38.36   A
ATOM   5815  CB  VAL A 111      23.054 -15.270  34.001  1.00 38.38   A
ATOM   5816  CG1 VAL A 111      23.198 -14.412  32.753  1.00 38.34   A
ATOM   5817  CG2 VAL A 111      23.812 -16.573  33.842  1.00 38.44   A
ATOM   5818  C   VAL A 111      22.829 -13.183  35.349  1.00 38.10   A
ATOM   5819  O   VAL A 111      23.297 -12.145  34.880  1.00 37.99   A
ATOM   5820  N   LYS A 112      21.663 -13.229  35.980  1.00 37.84   A
ATOM   5821  CA  LYS A 112      20.851 -12.036  36.163  1.00 37.63   A
ATOM   5822  CB  LYS A 112      19.477 -12.414  36.719  1.00 37.62   A
ATOM   5823  CG  LYS A 112      18.545 -11.233  36.904  1.00 37.60   A
ATOM   5824  CD  LYS A 112      17.185 -11.663  37.410  1.00 37.64   A
ATOM   5825  CE  LYS A 112      16.284 -10.457  37.615  1.00 37.70   A
ATOM   5826  NZ  LYS A 112      14.951 -10.845  38.142  1.00 37.88   A
ATOM   5827  C   LYS A 112      21.538 -11.050  37.105  1.00 37.48   A
ATOM   5828  O   LYS A 112      21.554  -9.846  36.850  1.00 37.36   A
ATOM   5829  N   GLU A 113      22.112 -11.565  38.189  1.00 37.26   A
ATOM   5830  CA  GLU A 113      22.796 -10.723  39.166  1.00 37.10   A
ATOM   5831  CB  GLU A 113      23.143 -11.537  40.420  1.00 37.36   A
ATOM   5832  CG  GLU A 113      23.579 -10.692  41.622  1.00 37.69   A
ATOM   5833  CD  GLU A 113      22.449  -9.851  42.207  1.00 37.86   A
ATOM   5834  OE1 GLU A 113      22.711  -9.076  43.157  1.00 37.95   A
ATOM   5835  OE2 GLU A 113      21.301  -9.970  41.723  1.00 37.89   A
ATOM   5836  C   GLU A 113      24.070 -10.117  38.573  1.00 36.80   A
ATOM   5837  O   GLU A 113      24.378  -8.949  38.808  1.00 36.69   A
ATOM   5838  N   GLN A 114      24.804 -10.914  37.803  1.00 36.47   A
ATOM   5839  CA  GLN A 114      26.037 -10.448  37.181  1.00 36.17   A
ATOM   5840  CB  GLN A 114      26.775 -11.622  36.527  1.00 36.48   A
ATOM   5841  CG  GLN A 114      27.387 -12.597  37.525  1.00 37.03   A
ATOM   5842  CD  GLN A 114      27.971 -13.841  36.869  1.00 37.38   A
ATOM   5843  OE1 GLN A 114      28.847 -13.752  36.005  1.00 37.53   A
ATOM   5844  NE2 GLN A 114      27.487 -15.012  37.282  1.00 37.45   A
ATOM   5845  C   GLN A 114      25.768  -9.359  36.148  1.00 35.76   A
ATOM   5846  O   GLN A 114      26.582  -8.452  35.963  1.00 35.71   A
ATOM   5847  N   MET A 115      24.622  -9.447  35.481  1.00 35.26   A
ATOM   5848  CA  MET A 115      24.253  -8.459  34.474  1.00 34.74   A
ATOM   5849  CB  MET A 115      23.147  -9.006  33.573  1.00 35.14   A
ATOM   5850  CG  MET A 115      22.929  -8.183  32.322  1.00 35.72   A
ATOM   5851  SD  MET A 115      24.425  -8.101  31.312  1.00 36.85   A
ATOM   5852  CE  MET A 115      25.020  -6.470  31.691  1.00 36.19   A
ATOM   5853  C   MET A 115      23.792  -7.164  35.137  1.00 34.07   A
ATOM   5854  O   MET A 115      24.214  -6.079  34.745  1.00 34.00   A
ATOM   5855  N   PHE A 116      22.926  -7.280  36.140  1.00 33.41   A
ATOM   5856  CA  PHE A 116      22.437  -6.104  36.856  1.00 32.72   A
ATOM   5857  CB  PHE A 116      21.485  -6.507  37.982  1.00 32.41   A
ATOM   5858  CG  PHE A 116      20.039  -6.520  37.583  1.00 32.03   A
ATOM   5859  CD1 PHE A 116      19.574  -7.415  36.627  1.00 31.76   A
ATOM   5860  CD2 PHE A 116      19.140  -5.630  38.164  1.00 31.87   A
ATOM   5861  CE1 PHE A 116      18.235  -7.426  36.257  1.00 31.75   A
ATOM   5862  CE2 PHE A 116      17.798  -5.632  37.801  1.00 31.79   A
ATOM   5863  CZ  PHE A 116      17.343  -6.532  36.845  1.00 31.63   A
ATOM   5864  C   PHE A 116      23.618  -5.353  37.452  1.00 32.46   A
ATOM   5865  O   PHE A 116      23.775  -4.147  37.253  1.00 32.41   A
ATOM   6152  N   TYR A 152       9.234  10.144  32.617  1.00  9.71   A
ATOM   6153  CA  TYR A 152       9.916   8.878  32.397  1.00  9.80   A
ATOM   6154  CB  TYR A 152      10.132   8.650  30.901  1.00  9.99   A
ATOM   6155  CG  TYR A 152      10.202   7.183  30.526  1.00 10.38   A
ATOM   6156  CD1 TYR A 152       9.213   6.281  30.944  1.00 10.55   A
ATOM   6157  CE1 TYR A 152       9.267   4.928  30.581  1.00 10.77   A
ATOM   6158  CD2 TYR A 152      11.243   6.698  29.742  1.00 10.42   A
ATOM   6159  CE2 TYR A 152      11.308   5.353  29.375  1.00 10.66   A
ATOM   6160  CZ  TYR A 152      10.325   4.477  29.792  1.00 10.74   A
ATOM   6161  OH  TYR A 152      10.393   3.156  29.410  1.00 10.82   A
ATOM   6162  C   TYR A 152      11.245   8.820  33.157  1.00  9.88   A
ATOM   6163  O   TYR A 152      11.655   7.755  33.621  1.00  9.73   A
ATOM   6164  N   TRP A 153      11.907   9.965  33.296  1.00  9.89   A
ATOM   6165  CA  TRP A 153      13.158  10.012  34.036  1.00 10.03   A
ATOM   6166  CB  TRP A 153      13.808  11.398  33.925  1.00 10.21   A
ATOM   6167  CG  TRP A 153      14.774  11.688  35.031  1.00 10.40   A
ATOM   6168  CD2 TRP A 153      15.930  10.920  35.389  1.00 10.68   A
ATOM   6169  CE2 TRP A 153      16.491  11.521  36.539  1.00 10.78   A
ATOM   6170  CE3 TRP A 153      16.544   9.783  34.853  1.00 10.67   A
ATOM   6171  CD1 TRP A 153      14.688  12.696  35.943  1.00 10.44   A
ATOM   6172  NE1 TRP A 153      15.714  12.603  36.854  1.00 10.64   A
ATOM   6173  CZ2 TRP A 153      17.637  11.018  37.167  1.00 10.84   A
ATOM   6174  CZ3 TRP A 153      17.689   9.282  35.478  1.00 10.82   A
ATOM   6175  CH2 TRP A 153      18.220   9.902  36.623  1.00 10.64   A
ATOM   6176  C   TRP A 153      12.893   9.676  35.502  1.00 10.03   A
ATOM   6177  O   TRP A 153      13.602   8.861  36.098  1.00 10.17   A
ATOM   6178  N   GLU A 154      11.869  10.295  36.078  1.00 10.10   A
ATOM   6179  CA  GLU A 154      11.524  10.048  37.474  1.00 10.17   A
ATOM   6180  CB  GLU A 154      10.403  11.001  37.919  1.00 10.10   A
ATOM   6181  CG  GLU A 154      10.138  11.016  39.422  1.00  9.74   A
ATOM   6182  CD  GLU A 154       9.268   9.858  39.879  1.00  9.86   A
ATOM   6183  OE1 GLU A 154       9.252   9.560  41.095  1.00  9.89   A
ATOM   6184  OE2 GLU A 154       8.588   9.247  39.027  1.00  9.57   A
ATOM   6185  C   GLU A 154      11.095   8.587  37.641  1.00 10.51   A
ATOM   6186  O   GLU A 154      11.481   7.927  38.608  1.00 10.53   A
ATOM   6187  N   ILE A 155      10.321   8.079  36.683  1.00 10.63   A
ATOM   6188  CA  ILE A 155       9.855   6.700  36.739  1.00 10.71   A
ATOM   6189  CB  ILE A 155       8.823   6.430  35.625  1.00 10.90   A
ATOM   6190  CG2 ILE A 155       8.485   4.944  35.555  1.00 10.77   A
ATOM   6191  CG1 ILE A 155       7.559   7.254  35.908  1.00 10.69   A
ATOM   6192  CD1 ILE A 155       6.531   7.198  34.810  1.00 10.76   A
ATOM   6193  C   ILE A 155      11.013   5.710  36.641  1.00 10.99   A
ATOM   6194  O   ILE A 155      11.147   4.802  37.475  1.00 10.97   A
ATOM   6195  N   CYS A 156      11.863   5.902  35.638  1.00 11.08   A
ATOM   6196  CA  CYS A 156      13.017   5.030  35.434  1.00 11.24   A
ATOM   6197  CB  CYS A 156      13.719   5.390  34.120  1.00 11.05   A
ATOM   6198  SG  CYS A 156      12.789   4.896  32.650  1.00 11.30   A
ATOM   6199  C   CYS A 156      14.018   5.108  36.583  1.00 11.50   A
ATOM   6200  O   CYS A 156      14.495   4.078  37.065  1.00 11.70   A
ATOM   6201  N   SER A 157      14.334   6.325  37.019  1.00 11.70   A
ATOM   6202  CA  SER A 157      15.289   6.512  38.105  1.00 12.05   A
ATOM   6203  CB  SER A 157      15.615   7.997  38.287  1.00 11.74   A
ATOM   6204  OG  SER A 157      14.494   8.732  38.739  1.00 11.48   A
ATOM   6205  C   SER A 157      14.789   5.924  39.424  1.00 12.41   A
ATOM   6206  O   SER A 157      15.585   5.500  40.266  1.00 12.70   A
ATOM   6207  N   THR A 158      13.475   5.905  39.612  1.00 12.70   A
ATOM   6208  CA  THR A 158      12.913   5.341  40.829  1.00 13.05   A
ATOM   6209  CB  THR A 158      11.379   5.466  40.853  1.00 13.03   A
ATOM   6210  OG1 THR A 158      11.014   6.842  41.007  1.00 12.82   A
ATOM   6211  CG2 THR A 158      10.791   4.659  42.011  1.00 12.99   A
ATOM   6212  C   THR A 158      13.284   3.863  40.939  1.00 13.54   A
ATOM   6213  O   THR A 158      13.754   3.407  41.981  1.00 13.26   A
ATOM   6214  N   THR A 159      13.068   3.113  39.863  1.00 14.14   A
ATOM   6215  CA  THR A 159      13.397   1.694  39.872  1.00 14.95   A
ATOM   6216  CB  THR A 159      12.878   0.995  38.597  1.00 15.00   A
ATOM   6217  OG1 THR A 159      11.445   1.015  38.607  1.00 15.26   A
ATOM   6218  CG2 THR A 159      13.356  -0.459  38.537  1.00 15.00   A
ATOM   6219  C   THR A 159      14.901   1.459  40.021  1.00 15.25   A
ATOM   6220  O   THR A 159      15.324   0.580  40.775  1.00 15.54   A
ATOM   6221  N   LEU A 160      15.709   2.249  39.323  1.00 15.71   A
ATOM   6222  CA  LEU A 160      17.158   2.105  39.410  1.00 16.22   A
ATOM   6223  CB  LEU A 160      17.851   3.066  38.437  1.00 16.17   A
ATOM   6224  CG  LEU A 160      17.681   2.778  36.940  1.00 16.23   A
ATOM   6225  CD1 LEU A 160      18.193   3.966  36.137  1.00 16.43   A
ATOM   6226  CD2 LEU A 160      18.413   1.502  36.548  1.00 15.89   A
ATOM   6227  C   LEU A 160      17.653   2.366  40.831  1.00 16.63   A
ATOM   6228  O   LEU A 160      18.557   1.683  41.316  1.00 16.60   A
ATOM   6229  N   LEU A 161      17.059   3.356  41.493  1.00 16.97   A
ATOM   6230  CA  LEU A 161      17.445   3.695  42.858  1.00 17.42   A
ATOM   6231  CB  LEU A 161      16.733   4.972  43.316  1.00 16.98   A
ATOM   6232  CG  LEU A 161      17.249   6.288  42.728  1.00 16.98   A
ATOM   6233  CD1 LEU A 161      16.334   7.429  43.147  1.00 16.61   A
ATOM   6234  CD2 LEU A 161      18.682   6.546  43.201  1.00 16.65   A
ATOM   6235  C   LEU A 161      17.132   2.548  43.818  1.00 17.85   A
ATOM   6236  O   LEU A 161      17.722   2.449  44.895  1.00 18.15   A
ATOM   6237  N   VAL A 162      16.196   1.691  43.428  1.00 17.99   A
ATOM   6238  CA  VAL A 162      15.831   0.548  44.245  1.00 18.31   A
ATOM   6239  CB  VAL A 162      14.611  -0.199  43.647  1.00 18.37   A
ATOM   6240  CG1 VAL A 162      14.406  -1.530  44.354  1.00 18.47   A
ATOM   6241  CG2 VAL A 162      13.356   0.660  43.788  1.00 18.42   A
ATOM   6242  C   VAL A 162      17.015  -0.418  44.340  1.00 18.61   A
ATOM   6243  O   VAL A 162      17.236  -1.048  45.378  1.00 18.71   A
ATOM   6244  N   PHE A 163      17.781  -0.520  43.257  1.00 18.71   A
ATOM   6245  CA  PHE A 163      18.938  -1.409  43.209  1.00 18.91   A
ATOM   6246  CB  PHE A 163      18.999  -2.128  41.852  1.00 18.88   A
ATOM   6247  CG  PHE A 163      17.789  -2.965  41.558  1.00 18.73   A
ATOM   6248  CD1 PHE A 163      16.734  -2.448  40.822  1.00 18.63   A
ATOM   6249  CD2 PHE A 163      17.678  -4.254  42.067  1.00 18.63   A
ATOM   6250  CE1 PHE A 163      15.584  -3.198  40.599  1.00 18.60   A
ATOM   6251  CE2 PHE A 163      16.529  -5.011  41.847  1.00 18.56   A
ATOM   6252  CZ  PHE A 163      15.483  -4.480  41.114  1.00 18.40   A
ATOM   6253  C   PHE A 163      20.262  -0.692  43.468  1.00 19.04   A
ATOM   6254  O   PHE A 163      21.251  -1.326  43.832  1.00 18.99   A
ATOM   6528  N   THR A 197       4.484  -1.111  45.252  1.00 22.77   A
ATOM   6529  CA  THR A 197       5.126  -2.297  44.695  1.00 22.69   A
ATOM   6530  CB  THR A 197       4.568  -2.649  43.296  1.00 22.64   A
ATOM   6531  OG1 THR A 197       4.713  -1.524  42.419  1.00 22.39   A
ATOM   6532  CG2 THR A 197       3.096  -3.040  43.393  1.00 22.49   A
ATOM   6533  C   THR A 197       6.627  -2.062  44.583  1.00 22.75   A
ATOM   6534  O   THR A 197       7.087  -0.922  44.636  1.00 22.48   A
ATOM   6535  N   LYS A 198       7.390  -3.139  44.428  1.00 22.84   A
ATOM   6536  CA  LYS A 198       8.835  -3.014  44.305  1.00 23.15   A
ATOM   6537  CB  LYS A 198       9.503  -4.385  44.446  1.00 23.45   A
ATOM   6538  CG  LYS A 198      11.027  -4.339  44.481  1.00 23.89   A
ATOM   6539  CD  LYS A 198      11.617  -5.719  44.748  1.00 24.34   A
ATOM   6540  CE  LYS A 198      13.135  -5.669  44.905  1.00 24.64   A
ATOM   6541  NZ  LYS A 198      13.715  -7.011  45.224  1.00 24.86   A
ATOM   6542  C   LYS A 198       9.201  -2.391  42.960  1.00 23.13   A
ATOM   6543  O   LYS A 198       9.917  -1.393  42.909  1.00 23.17   A
ATOM   6544  N   LEU A 199       8.706  -2.980  41.876  1.00 23.24   A
ATOM   6545  CA  LEU A 199       8.989  -2.475  40.537  1.00 23.52   A
ATOM   6546  CB  LEU A 199       9.571  -3.588  39.652  1.00 23.79   A
ATOM   6547  CG  LEU A 199      10.941  -4.180  40.010  1.00 24.11   A
ATOM   6548  CD1 LEU A 199      11.934  -3.056  40.302  1.00 24.28   A
ATOM   6549  CD2 LEU A 199      10.810  -5.078  41.220  1.00 24.55   A
ATOM   6550  C   LEU A 199       7.739  -1.894  39.871  1.00 23.53   A
ATOM   6551  O   LEU A 199       6.704  -1.767  40.557  1.00 23.60   A
ATOM   6552  OXT LEU A 199       7.807  -1.566  38.669  1.00 23.55   A
ATOM   6688  N1  GSH H 200       8.305  -2.844  24.998  1.00 20.97   H
ATOM   6689  CA1 GSH H 200       6.911  -3.081  25.371  1.00 20.94   H
ATOM   6690  C1  GSH H 200       6.240  -1.805  25.930  1.00 20.69   H
ATOM   6691  O11 GSH H 200       6.937  -0.824  26.213  1.00 20.48   H
ATOM   6692  O12 GSH H 200       4.943  -1.894  26.178  1.00 20.60   H
ATOM   6693  CB1 GSH H 200       6.878  -4.158  26.465  1.00 21.02   H
ATOM   6694  CG1 GSH H 200       7.003  -5.588  25.927  1.00 21.34   H
ATOM   6695  CD1 GSH H 200       7.105  -6.535  27.153  1.00 21.26   H
ATOM   6696  OE1 GSH H 200       7.995  -7.376  27.180  1.00 21.54   H
ATOM   6697  N2  GSH H 200       6.151  -6.418  28.106  1.00 21.27   H
ATOM   6698  CA2 GSH H 200       6.171  -7.317  29.280  1.00 21.32   H
ATOM   6699  C2  GSH H 200       5.234  -8.508  29.053  1.00 21.45   H
ATOM   6700  O2  GSH H 200       4.092  -8.371  28.603  1.00 21.33   H
ATOM   6701  CB2 GSH H 200       5.676  -6.608  30.562  1.00 21.16   H
ATOM   6702  SG2 GSH H 200       6.895  -5.457  31.266  1.00 20.43   H
ATOM   6703  N3  GSH H 200       5.687  -9.697  29.521  1.00 21.62   H
ATOM   6704  CA3 GSH H 200       4.848 -10.902  29.598  1.00 21.77   H
ATOM   6705  C3  GSH H 200       5.235 -11.857  28.486  1.00 22.03   H
ATOM   6706  O31 GSH H 200       4.505 -12.857  28.339  1.00 22.01   H
ATOM   6707  O32 GSH H 200       6.217 -11.556  27.749  1.00 22.31   H
ATOM   6708  C1  U46 X 201      10.418  -9.029  32.023  1.00 34.62   X
ATOM   6709  C2  U46 X 201       9.663 -10.080  32.823  1.00 34.77   X
ATOM   6710  C3  U46 X 201       9.043  -9.215  33.968  1.00 34.58   X
ATOM   6711  C4  U46 X 201       8.603  -7.944  33.186  1.00 34.52   X
ATOM   6712  C5  U46 X 201       9.105  -8.297  31.751  1.00 34.55   X
ATOM   6713  O6  U46 X 201       8.305  -9.318  31.150  1.00 34.69   X
ATOM   6714  C7  U46 X 201       8.626 -10.560  31.780  1.00 34.71   X
ATOM   6715  C14 U46 X 201       9.215  -6.627  33.663  1.00 33.95   X
ATOM   6716  C16 U46 X 201       8.636  -5.646  34.388  1.00 33.42   X
ATOM   6717  C18 U46 X 201       9.270  -4.351  34.859  1.00 33.17   X
ATOM   6718  C20 U46 X 201       9.952  -3.549  33.738  1.00 33.13   X
ATOM   6719  C21 U46 X 201      10.163  -2.068  34.122  1.00 33.29   X
ATOM   6720  C24 U46 X 201      10.959  -1.283  33.062  1.00 33.44   X
ATOM   6721  C27 U46 X 201      10.626   0.219  33.069  1.00 33.39   X
ATOM   6722  C30 U46 X 201      10.896   0.871  31.709  1.00 33.48   X
ATOM   6723  O36 U46 X 201      10.227  -4.658  35.841  1.00 33.24   X
ATOM   6724  C39 U46 X 201       7.877  -9.902  34.751  1.00 34.95   X
ATOM   6725  C41 U46 X 201       8.032  -9.785  36.257  1.00 35.34   X
ATOM   6726  C44 U46 X 201       8.610 -10.654  37.130  1.00 35.62   X
ATOM   6727  C46 U46 X 201       9.261 -11.994  36.823  1.00 35.69   X
ATOM   6728  C48 U46 X 201      10.726 -12.086  37.288  1.00 35.70   X
ATOM   6729  C51 U46 X 201      11.026 -13.433  37.990  1.00 35.67   X
ATOM   6730  C54 U46 X 201      12.522 -13.820  37.936  1.00 35.71   X
ATOM   6731  O57 U46 X 201      12.742 -14.998  38.563  1.00 35.58   X
ATOM   6732  O58 U46 X 201      13.394 -13.172  37.412  1.00 35.68   X
ATOM   6734 CA+2 CA2 M 902      12.234   1.221  22.856  1.00 26.18   M
ATOM   6797  OH2 WAT S  66       8.810  -7.551  20.104  1.00 14.22   S
ATOM   6798  OH2 WAT S  67      10.805  -8.913  21.442  1.00 18.79   S
ATOM   6799  OH2 WAT S  68       7.756  -6.308  22.319  1.00 11.88   S
ATOM   6800  OH2 WAT S  69       5.816  -8.813  20.585  1.00 16.62   S
ATOM   6801  OH2 WAT S  70       5.092  -6.137  21.429  1.00  8.34   S
ATOM   6802  OH2 WAT S  71       5.256 -11.109  19.213  1.00 14.67   S
ATOM   6803  OH2 WAT S  72       3.023  -5.015  22.562  1.00  5.39   S
ATOM   6804  OH2 WAT S  73       0.826  -6.659  23.058  1.00 10.24   S
ATOM   6805  OH2 WAT S  74       2.776  -3.513  24.834  1.00 13.89   S
ATOM   6806  OH2 WAT S  75      11.519  -4.838  25.573  1.00 37.60   S
ATOM   6807  OH2 WAT S  76       8.072  -9.994  27.106  1.00 23.21   S
ATOM   6808  OH2 WAT S  77      17.600  -2.336  25.194  1.00 29.44   S
ATOM   6955  OH2 WAT S 228      -2.665  -1.375  34.872  1.00 12.13   S
ATOM   6956  OH2 WAT S 229       0.635  -8.538  38.751  1.00 19.36   S
ATOM   6957  OH2 WAT S 230       9.165  -7.382  41.775  1.00 33.05   S
ATOM   6958  OH2 WAT S 231       1.469   2.057  40.259  1.00 10.55   S
ATOM   6959  OH2 WAT S 232       2.424  -0.150  41.673  1.00  7.92   S
ATOM   6960  OH2 WAT S 233       4.681   1.576  43.702  1.00 20.75   S
ATOM   6961  OH2 WAT S 234       9.069   3.394  38.480  1.00 10.13   S
ATOM   6962  OH2 WAT S 235       8.873   1.530  36.291  1.00 19.33   S
ATOM   6963  OH2 WAT S 236       9.962  -0.719  37.350  1.00  9.21   S
ATOM   6964  OH2 WAT S 237       6.538   3.283  32.602  1.00  4.33   S
ATOM   6966  OH2 WAT S 239       6.866  -5.224  41.878  1.00 15.47   S
ATOM   7098  OH2 WAT S 376      -2.658  -5.119  20.477  1.00 32.13   S
ATOM   7100  OH2 WAT S 378       9.041   5.776  21.830  1.00 29.33   S
ATOM   7101  OH2 WAT S 379      16.468  -6.279  25.400  1.00 37.77   S
ATOM   7102  OH2 WAT S 380      11.532  -7.763  23.742  1.00 26.56   S
ATOM   7103  OH2 WAT S 381      20.121  -7.464  24.596  1.00 31.37   S
ATOM   7206  OH2 WAT S 487      -6.959  -2.973  28.857  1.00 26.99   S
ATOM   7220  OH2 WAT S 502      19.741 -12.637  30.102  1.00 30.06   S
ATOM   7228  OH2 WAT S 511      10.932   3.058  22.095  1.00 23.73   S
ATOM   7252  OH2 WAT S 537      14.068   2.624  22.159  1.00 17.19   S
ATOM   7253  OH2 WAT S 538      10.354  -0.297  22.259  1.00 23.05   S
ATOM   7254  OH2 WAT S 539      14.359   0.199  23.830  1.00 17.88   S
ATOM   7255  OH2 WAT S 540      13.565  -1.416  21.690  1.00 21.98   S
ATOM   7256  OH2 WAT S 541      14.359  -2.488  23.994  1.00 24.68   S
ATOM   7257  OH2 WAT S 542       6.700   1.457  23.387  1.00  7.45   S
ATOM   7260  OH2 WAT S 545       6.810   4.437  20.115  1.00  9.33   S
ATOM   7262  OH2 WAT S 548       7.372   2.188  29.676  1.00 13.81   S
ATOM   7263  OH2 WAT S 551      12.593   1.210  20.664  1.00 23.28   S
ATOM   7279  OH2 WAT S 568       9.152  -7.664  24.541  1.00 28.73   S
ATOM   7330  OH2 WAT S 621      -0.052  -8.417  43.049  1.00 41.72   S
ATOM   7331  OH2 WAT S 622       4.610  -6.488  42.101  1.00 39.75   S
ATOM   7334  OH2 WAT S 625      -5.505 -11.363  37.210  1.00 32.13   S
ATOM   7365  OH2 WAT S 659      12.799 -12.693  21.817  1.00 29.74   S
ATOM   7419  OH2 WAT S 719       3.738  -8.441  39.590  1.00 44.76   S
ATOM   7420  OH2 WAT S 720      -3.644  -7.487  40.846  1.00 28.21   S
ATOM   7421  OH2 WAT S 721       9.250   0.354  24.552  1.00 31.35   S
ATOM   7469  OH2 WAT S 779      13.344 -12.993  24.338  1.00 33.74   S
ATOM   7478  OH2 WAT S 797       9.999  -4.902  29.944  1.00 42.20   S
【００５０】
【表４】
ヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−メタノエポキシプロスタグランジンＦ２α（Ｕ４６）との複合体の３次元構造座標
ATOM   4966  N   TYR A   8      52.373  40.696  69.223  1.00  5.08   A
ATOM   4967  CA  TYR A   8      50.981  40.835  69.625  1.00  5.19   A
ATOM   4968  CB  TYR A   8      50.387  42.136  69.066  1.00  5.85   A
ATOM   4969  CG  TYR A   8      49.055  42.515  69.678  1.00  5.32   A
ATOM   4970  CD1 TYR A   8      48.943  42.758  71.047  1.00  5.34   A
ATOM   4971  CE1 TYR A   8      47.727  43.124  71.619  1.00  5.53   A
ATOM   4972  CD2 TYR A   8      47.908  42.646  68.889  1.00  5.77   A
ATOM   4973  CE2 TYR A   8      46.685  43.014  69.451  1.00  5.46   A
ATOM   4974  CZ  TYR A   8      46.604  43.251  70.815  1.00  5.16   A
ATOM   4975  OH  TYR A   8      45.399  43.630  71.365  1.00  5.90   A
ATOM   4976  C   TYR A   8      50.221  39.643  69.062  1.00  5.81   A
ATOM   4977  O   TYR A   8      50.803  38.783  68.405  1.00  6.16   A
ATOM   4978  N   PHE A   9      48.928  39.581  69.347  1.00  6.65   A
ATOM   4979  CA  PHE A   9      48.090  38.518  68.812  1.00  7.22   A
ATOM   4980  CB  PHE A   9      46.752  38.461  69.556  1.00 10.27   A
ATOM   4981  CG  PHE A   9      46.868  38.040  70.993  1.00 10.70   A
ATOM   4982  CD1 PHE A   9      46.584  38.935  72.021  1.00 13.85   A
ATOM   4983  CD2 PHE A   9      47.254  36.744  71.320  1.00 12.21   A
ATOM   4984  CE1 PHE A   9      46.683  38.540  73.355  1.00 15.04   A
ATOM   4985  CE2 PHE A   9      47.356  36.343  72.650  1.00 13.46   A
ATOM   4986  CZ  PHE A   9      47.070  37.242  73.668  1.00 14.40   A
ATOM   4987  C   PHE A   9      47.811  38.860  67.350  1.00  6.45   A
ATOM   4988  O   PHE A   9      48.173  39.943  66.873  1.00  6.51   A
ATOM   4989  N   ASN A  10      47.178  37.938  66.632  1.00  7.20   A
ATOM   4990  CA  ASN A  10      46.822  38.209  65.248  1.00  7.50   A
ATOM   4991  CB  ASN A  10      46.676  36.915  64.445  1.00  8.81   A
ATOM   4992  CG  ASN A  10      46.265  37.172  63.010  1.00 10.65   A
ATOM   4993  OD1 ASN A  10      46.628  38.191  62.423  1.00  9.77   A
ATOM   4994  ND2 ASN A  10      45.515  36.240  62.430  1.00 12.72   A
ATOM   4995  C   ASN A  10      45.489  38.952  65.305  1.00  7.31   A
ATOM   4996  O   ASN A  10      44.425  38.386  65.058  1.00  7.42   A
ATOM   4997  N   MET A  11      45.573  40.228  65.668  1.00  6.93   A
ATOM   4998  CA  MET A  11      44.424  41.120  65.791  1.00  6.61   A
ATOM   4999  CB  MET A  11      43.816  41.082  67.202  1.00  9.76   A
ATOM   5000  CG  MET A  11      43.251  39.768  67.703  1.00 12.58   A
ATOM   5001  SD  MET A  11      42.429  40.034  69.312  1.00 16.46   A
ATOM   5002  CE  MET A  11      43.822  40.416  70.355  1.00 18.60   A
ATOM   5003  C   MET A  11      44.958  42.529  65.612  1.00  4.89   A
ATOM   5004  O   MET A  11      46.165  42.765  65.730  1.00  5.10   A
ATOM   5005  N   ARG A  12      44.065  43.471  65.333  1.00  4.88   A
ATOM   5006  CA  ARG A  12      44.481  44.863  65.248  1.00  4.58   A
ATOM   5007  CB  ARG A  12      43.377  45.722  64.630  1.00  4.90   A
ATOM   5008  CG  ARG A  12      43.101  45.396  63.166  1.00  4.93   A
ATOM   5009  CD  ARG A  12      42.125  46.404  62.550  1.00  5.92   A
ATOM   5010  NE  ARG A  12      40.874  46.486  63.301  1.00  5.59   A
ATOM   5011  CZ  ARG A  12      39.925  45.558  63.273  1.00  6.68   A
ATOM   5012  NH1 ARG A  12      40.073  44.477  62.519  1.00  6.84   A
ATOM   5013  NH2 ARG A  12      38.841  45.699  64.025  1.00  7.34   A
ATOM   5014  C   ARG A  12      44.716  45.251  66.711  1.00  4.87   A
ATOM   5015  O   ARG A  12      45.835  45.568  67.112  1.00  5.24   A
ATOM   5016  N   GLY A  13      43.647  45.193  67.500  1.00  5.06   A
ATOM   5017  CA  GLY A  13      43.722  45.495  68.916  1.00  4.83   A
ATOM   5018  C   GLY A  13      44.620  46.641  69.327  1.00  4.65   A
ATOM   5019  O   GLY A  13      44.611  47.717  68.718  1.00  5.04   A
ATOM   5020  N   ARG A  14      45.404  46.397  70.373  1.00  4.18   A
ATOM   5021  CA  ARG A  14      46.305  47.398  70.929  1.00  5.36   A
ATOM   5022  CB  ARG A  14      46.573  47.085  72.401  1.00  5.09   A
ATOM   5023  CG  ARG A  14      45.315  47.228  73.252  1.00  5.96   A
ATOM   5024  CD  ARG A  14      45.594  46.965  74.727  1.00  8.03   A
ATOM   5025  NE  ARG A  14      44.524  47.502  75.570  1.00 10.77   A
ATOM   5026  CZ  ARG A  14      43.670  46.772  76.281  1.00 12.04   A
ATOM   5027  NH1 ARG A  14      43.742  45.449  76.268  1.00 13.88   A
ATOM   5028  NH2 ARG A  14      42.740  47.372  77.011  1.00 15.99   A
ATOM   5029  C   ARG A  14      47.618  47.571  70.188  1.00  4.92   A
ATOM   5030  O   ARG A  14      48.394  48.465  70.509  1.00  6.47   A
ATOM   5031  N   ALA A  15      47.878  46.728  69.199  1.00  4.71   A
ATOM   5032  CA  ALA A  15      49.111  46.864  68.439  1.00  4.73   A
ATOM   5033  CB  ALA A  15      49.617  45.491  68.020  1.00  7.01   A
ATOM   5034  C   ALA A  15      48.907  47.729  67.203  1.00  4.72   A
ATOM   5035  O   ALA A  15      49.867  48.277  66.661  1.00  4.50   A
ATOM   5036  N   GLU A  16      47.656  47.882  66.775  1.00  4.21   A
ATOM   5037  CA  GLU A  16      47.386  48.606  65.542  1.00  4.17   A
ATOM   5038  CB  GLU A  16      45.888  48.555  65.220  1.00  4.19   A
ATOM   5039  CG  GLU A  16      45.564  48.801  63.741  1.00  5.10   A
ATOM   5040  CD  GLU A  16      46.069  47.700  62.804  1.00  5.24   A
ATOM   5041  OE1 GLU A  16      46.619  46.682  63.283  1.00  5.72   A
ATOM   5042  OE2 GLU A  16      45.907  47.864  61.575  1.00  5.89   A
ATOM   5043  C   GLU A  16      47.904  50.034  65.463  1.00  4.67   A
ATOM   5044  O   GLU A  16      48.364  50.459  64.404  1.00  4.75   A
ATOM   5045  N   ILE A  17      47.859  50.776  66.566  1.00  4.26   A
ATOM   5046  CA  ILE A  17      48.351  52.146  66.529  1.00  4.04   A
ATOM   5047  CB  ILE A  17      48.092  52.876  67.889  1.00  5.08   A
ATOM   5048  CG2 ILE A  17      48.797  52.165  69.029  1.00  5.12   A
ATOM   5049  CG1 ILE A  17      48.539  54.337  67.794  1.00  4.72   A
ATOM   5050  CD1 ILE A  17      47.815  55.138  66.720  1.00  6.77   A
ATOM   5051  C   ILE A  17      49.841  52.150  66.158  1.00  4.37   A
ATOM   5052  O   ILE A  17      50.301  53.003  65.394  1.00  5.08   A
ATOM   5242  N   TRP A  39      50.877  31.481  73.859  1.00 14.53   A
ATOM   5243  CA  TRP A  39      50.756  32.520  74.879  1.00 13.46   A
ATOM   5244  CB  TRP A  39      49.282  32.747  75.231  1.00 13.58   A
ATOM   5245  CG  TRP A  39      49.060  33.765  76.321  1.00 12.94   A
ATOM   5246  CD2 TRP A  39      49.582  35.102  76.384  1.00 12.06   A
ATOM   5247  CE2 TRP A  39      49.128  35.671  77.593  1.00 12.15   A
ATOM   5248  CE3 TRP A  39      50.392  35.874  75.537  1.00 10.40   A
ATOM   5249  CD1 TRP A  39      48.328  33.591  77.460  1.00 13.75   A
ATOM   5250  NE1 TRP A  39      48.365  34.728  78.230  1.00 13.97   A
ATOM   5251  CZ2 TRP A  39      49.454  36.974  77.981  1.00 11.46   A
ATOM   5252  CZ3 TRP A  39      50.717  37.176  75.926  1.00 10.56   A
ATOM   5253  CH2 TRP A  39      50.247  37.709  77.137  1.00 10.60   A
ATOM   5254  C   TRP A  39      51.564  32.262  76.156  1.00 14.42   A
ATOM   5255  O   TRP A  39      52.316  33.127  76.592  1.00 13.42   A
ATOM   5256  N   PRO A  40      51.424  31.076  76.774  1.00 13.83   A
ATOM   5257  CD  PRO A  40      50.509  29.950  76.512  1.00 15.37   A
ATOM   5258  CA  PRO A  40      52.202  30.843  77.995  1.00 13.84   A
ATOM   5259  CB  PRO A  40      51.885  29.388  78.329  1.00 14.82   A
ATOM   5260  CG  PRO A  40      50.467  29.254  77.861  1.00 15.27   A
ATOM   5261  C   PRO A  40      53.697  31.089  77.809  1.00 14.02   A
ATOM   5262  O   PRO A  40      54.342  31.712  78.656  1.00 14.68   A
ATOM   5263  N   GLU A  41      54.245  30.606  76.700  1.00 14.37   A
ATOM   5264  CA  GLU A  41      55.664  30.784  76.422  1.00 15.32   A
ATOM   5265  CB  GLU A  41      56.079  29.953  75.205  1.00 18.64   A
ATOM   5266  CG  GLU A  41      54.940  29.199  74.548  1.00 25.28   A
ATOM   5267  CD  GLU A  41      55.423  28.170  73.548  1.00 27.49   A
ATOM   5268  OE1 GLU A  41      56.616  28.201  73.183  1.00 29.60   A
ATOM   5269  OE2 GLU A  41      54.608  27.334  73.116  1.00 30.19   A
ATOM   5270  C   GLU A  41      56.005  32.253  76.188  1.00 13.50   A
ATOM   5271  O   GLU A  41      56.988  32.761  76.723  1.00 15.87   A
ATOM   5272  N   ILE A  42      55.190  32.931  75.388  1.00 12.31   A
ATOM   5273  CA  ILE A  42      55.413  34.342  75.095  1.00 12.42   A
ATOM   5274  CB  ILE A  42      54.407  34.852  74.031  1.00 12.64   A
ATOM   5275  CG2 ILE A  42      54.485  36.374  73.916  1.00 12.49   A
ATOM   5276  CG1 ILE A  42      54.697  34.197  72.677  1.00 14.88   A
ATOM   5277  CD1 ILE A  42      56.018  34.607  72.054  1.00 16.40   A
ATOM   5278  C   ILE A  42      55.276  35.196  76.358  1.00 10.62   A
ATOM   5279  O   ILE A  42      56.111  36.063  76.625  1.00 11.25   A
ATOM   5280  N   LYS A  43      54.228  34.941  77.131  1.00 11.00   A
ATOM   5281  CA  LYS A  43      53.969  35.697  78.351  1.00 10.64   A
ATOM   5282  CB  LYS A  43      52.722  35.144  79.052  1.00  9.83   A
ATOM   5283  CG  LYS A  43      52.292  35.936  80.279  1.00 10.83   A
ATOM   5284  CD  LYS A  43      51.053  35.326  80.910  1.00 12.63   A
ATOM   5285  CE  LYS A  43      50.652  36.051  82.183  1.00 14.51   A
ATOM   5286  NZ  LYS A  43      49.477  35.397  82.820  1.00 14.93   A
ATOM   5287  C   LYS A  43      55.143  35.703  79.323  1.00 12.13   A
ATOM   5288  O   LYS A  43      55.384  36.699  80.005  1.00 12.18   A
ATOM   5328  N   GLY A  49      53.610  40.833  81.753  1.00  7.16   A
ATOM   5329  CA  GLY A  49      52.668  39.832  81.287  1.00  8.61   A
ATOM   5330  C   GLY A  49      51.654  40.290  80.260  1.00  6.93   A
ATOM   5331  O   GLY A  49      50.653  39.608  80.038  1.00  7.98   A
ATOM   5332  N   LYS A  50      51.907  41.429  79.619  1.00  6.55   A
ATOM   5333  CA  LYS A  50      50.976  41.949  78.625  1.00  6.43   A
ATOM   5334  CB  LYS A  50      50.305  43.240  79.120  1.00  7.04   A
ATOM   5335  CG  LYS A  50      49.749  43.196  80.530  1.00  9.59   A
ATOM   5336  CD  LYS A  50      48.616  42.198  80.672  1.00 11.11   A
ATOM   5337  CE  LYS A  50      48.089  42.190  82.097  1.00 15.13   A
ATOM   5338  NZ  LYS A  50      49.205  42.086  83.079  1.00 17.69   A
ATOM   5339  C   LYS A  50      51.641  42.272  77.300  1.00  5.28   A
ATOM   5340  O   LYS A  50      52.846  42.538  77.232  1.00  5.40   A
ATOM   5341  N   ILE A  51      50.837  42.241  76.247  1.00  4.98   A
ATOM   5342  CA  ILE A  51      51.300  42.612  74.923  1.00  5.31   A
ATOM   5343  CB  ILE A  51      51.297  41.414  73.929  1.00  6.08   A
ATOM   5344  CG2 ILE A  51      52.577  40.606  74.121  1.00  7.61   A
ATOM   5345  CG1 ILE A  51      50.044  40.552  74.104  1.00  7.83   A
ATOM   5346  CD1 ILE A  51      49.971  39.380  73.132  1.00 11.35   A
ATOM   5347  C   ILE A  51      50.350  43.716  74.449  1.00  4.83   A
ATOM   5348  O   ILE A  51      49.228  43.847  74.929  1.00  5.85   A
ATOM   5349  N   PRO A  52      50.778  44.515  73.461  1.00  4.61   A
ATOM   5350  CD  PRO A  52      50.013  45.710  73.057  1.00  4.91   A
ATOM   5351  CA  PRO A  52      52.047  44.434  72.746  1.00  4.74   A
ATOM   5352  CB  PRO A  52      51.803  45.352  71.556  1.00  5.22   A
ATOM   5353  CG  PRO A  52      51.008  46.472  72.190  1.00  6.07   A
ATOM   5354  C   PRO A  52      53.327  44.841  73.456  1.00  5.16   A
ATOM   5355  O   PRO A  52      53.326  45.548  74.469  1.00  4.84   A
ATOM   5356  N   ILE A  53      54.423  44.329  72.909  1.00  4.77   A
ATOM   5357  CA  ILE A  53      55.747  44.742  73.323  1.00  4.63   A
ATOM   5358  CB  ILE A  53      56.576  43.680  74.116  1.00  5.58   A
ATOM   5359  CG2 ILE A  53      55.986  43.498  75.498  1.00  6.57   A
ATOM   5360  CG1 ILE A  53      56.711  42.376  73.332  1.00  6.10   A
ATOM   5361  CD1 ILE A  53      57.853  41.501  73.831  1.00  8.86   A
ATOM   5362  C   ILE A  53      56.439  45.024  71.998  1.00  4.92   A
ATOM   5363  O   ILE A  53      56.056  44.484  70.951  1.00  4.78   A
ATOM   5423  N   HIS A  62      57.230  48.257  76.387  1.00  5.48   A
ATOM   5424  CA  HIS A  62      55.869  47.762  76.529  1.00  5.13   A
ATOM   5425  CB  HIS A  62      55.742  46.832  77.744  1.00  5.58   A
ATOM   5426  CG  HIS A  62      55.930  47.514  79.060  1.00  4.58   A
ATOM   5427  CD2 HIS A  62      57.037  48.000  79.664  1.00  5.33   A
ATOM   5428  ND1 HIS A  62      54.877  47.778  79.911  1.00  5.59   A
ATOM   5429  CE1 HIS A  62      55.333  48.400  80.982  1.00  5.03   A
ATOM   5430  NE2 HIS A  62      56.639  48.549  80.860  1.00  6.03   A
ATOM   5431  C   HIS A  62      54.925  48.962  76.626  1.00  4.66   A
ATOM   5432  O   HIS A  62      55.386  50.105  76.654  1.00  5.51   A
ATOM   5433  N   GLN A  63      53.619  48.684  76.647  1.00  4.29   A
ATOM   5434  CA  GLN A  63      52.542  49.684  76.704  1.00  4.47   A
ATOM   5435  CB  GLN A  63      52.799  50.722  77.803  1.00  5.14   A
ATOM   5436  CG  GLN A  63      52.408  50.230  79.196  1.00  5.62   A
ATOM   5437  CD  GLN A  63      50.906  50.052  79.366  1.00  5.35   A
ATOM   5438  OE1 GLN A  63      50.112  50.483  78.523  1.00  4.91   A
ATOM   5439  NE2 GLN A  63      50.508  49.434  80.474  1.00  5.54   A
ATOM   5440  C   GLN A  63      52.378  50.337  75.335  1.00  4.53   A
ATOM   5441  O   GLN A  63      53.197  51.150  74.908  1.00  4.75   A
ATOM   5442  N   SER A  64      51.298  49.970  74.652  1.00  4.47   A
ATOM   5443  CA  SER A  64      51.049  50.446  73.299  1.00  5.16   A
ATOM   5444  CB  SER A  64      49.693  49.935  72.796  1.00  4.88   A
ATOM   5445  OG  SER A  64      48.605  50.551  73.460  1.00  5.68   A
ATOM   5446  C   SER A  64      51.149  51.942  73.054  1.00  4.97   A
ATOM   5447  O   SER A  64      51.742  52.366  72.062  1.00  5.10   A
ATOM   5448  N   LEU A  65      50.583  52.749  73.943  1.00  4.29   A
ATOM   5449  CA  LEU A  65      50.616  54.189  73.744  1.00  4.24   A
ATOM   5450  CB  LEU A  65      49.468  54.843  74.514  1.00  5.94   A
ATOM   5451  CG  LEU A  65      48.110  54.218  74.171  1.00  6.96   A
ATOM   5452  CD1 LEU A  65      47.017  54.953  74.937  1.00  9.08   A
ATOM   5453  CD2 LEU A  65      47.857  54.274  72.666  1.00  8.54   A
ATOM   5454  C   LEU A  65      51.962  54.802  74.114  1.00  4.91   A
ATOM   5455  O   LEU A  65      52.360  55.817  73.544  1.00  5.28   A
ATOM   5662  N   ASP A  93      44.344  59.210  75.556  1.00  4.56   A
ATOM   5663  CA  ASP A  93      43.975  58.590  76.829  1.00  4.81   A
ATOM   5664  CB  ASP A  93      44.674  59.281  78.008  1.00  5.82   A
ATOM   5665  CG  ASP A  93      46.052  58.688  78.299  1.00  6.27   A
ATOM   5666  OD1 ASP A  93      46.654  59.050  79.336  1.00  8.17   A
ATOM   5667  OD2 ASP A  93      46.534  57.858  77.497  1.00  6.94   A
ATOM   5668  C   ASP A  93      42.455  58.581  77.031  1.00  4.64   A
ATOM   5669  O   ASP A  93      41.914  57.667  77.647  1.00  5.45   A
ATOM   5670  N   THR A  94      41.760  59.589  76.513  1.00  4.84   A
ATOM   5671  CA  THR A  94      40.307  59.616  76.642  1.00  5.76   A
ATOM   5672  CB  THR A  94      39.745  60.972  76.166  1.00  6.34   A
ATOM   5673  OG1 THR A  94      40.156  61.992  77.086  1.00  7.42   A
ATOM   5674  CG2 THR A  94      38.223  60.943  76.110  1.00  8.19   A
ATOM   5675  C   THR A  94      39.718  58.460  75.825  1.00  6.13   A
ATOM   5676  O   THR A  94      38.803  57.764  76.276  1.00  6.09   A
ATOM   5677  N   LEU A  95      40.253  58.247  74.628  1.00  4.62   A
ATOM   5678  CA  LEU A  95      39.788  57.153  73.785  1.00  5.06   A
ATOM   5679  CB  LEU A  95      40.426  57.233  72.400  1.00  5.92   A
ATOM   5680  CG  LEU A  95      39.966  58.395  71.519  1.00  6.51   A
ATOM   5681  CD1 LEU A  95      40.809  58.448  70.253  1.00  7.81   A
ATOM   5682  CD2 LEU A  95      38.495  58.215  71.174  1.00  8.77   A
ATOM   5683  C   LEU A  95      40.143  55.819  74.423  1.00  4.85   A
ATOM   5684  O   LEU A  95      39.321  54.907  74.480  1.00  5.32   A
ATOM   5685  N   ASP A  96      41.373  55.711  74.912  1.00  5.08   A
ATOM   5686  CA  ASP A  96      41.830  54.472  75.524  1.00  4.86   A
ATOM   5687  CB  ASP A  96      43.328  54.556  75.817  1.00  5.00   A
ATOM   5688  CG  ASP A  96      43.975  53.191  75.916  1.00  6.28   A
ATOM   5689  OD1 ASP A  96      43.865  52.415  74.945  1.00  7.24   A
ATOM   5690  OD2 ASP A  96      44.593  52.896  76.958  1.00  8.87   A
ATOM   5691  C   ASP A  96      41.056  54.146  76.797  1.00  5.03   A
ATOM   5692  O   ASP A  96      40.784  52.978  77.082  1.00  5.59   A
ATOM   5693  N   ASP A  97      40.702  55.173  77.564  1.00  5.23   A
ATOM   5694  CA  ASP A  97      39.926  54.974  78.784  1.00  5.46   A
ATOM   5695  CB  ASP A  97      39.585  56.317  79.436  1.00  6.58   A
ATOM   5696  CG  ASP A  97      40.721  56.890  80.261  1.00  6.62   A
ATOM   5697  OD1 ASP A  97      40.597  58.061  80.677  1.00  7.17   A
ATOM   5698  OD2 ASP A  97      41.721  56.185  80.504  1.00  7.79   A
ATOM   5699  C   ASP A  97      38.621  54.269  78.426  1.00  6.00   A
ATOM   5700  O   ASP A  97      38.207  53.322  79.100  1.00  6.84   A
ATOM   5701  N   PHE A  98      37.969  54.732  77.364  1.00  5.70   A
ATOM   5702  CA  PHE A  98      36.712  54.122  76.964  1.00  5.97   A
ATOM   5703  CB  PHE A  98      36.013  54.962  75.898  1.00  6.49   A
ATOM   5704  CG  PHE A  98      34.603  54.532  75.635  1.00  7.36   A
ATOM   5705  CD1 PHE A  98      33.662  54.547  76.659  1.00  9.72   A
ATOM   5706  CD2 PHE A  98      34.217  54.088  74.379  1.00  7.45   A
ATOM   5707  CE1 PHE A  98      32.354  54.123  76.434  1.00 10.12   A
ATOM   5708  CE2 PHE A  98      32.911  53.662  74.140  1.00  9.08   A
ATOM   5709  CZ  PHE A  98      31.979  53.680  75.172  1.00  9.33   A
ATOM   5710  C   PHE A  98      36.906  52.698  76.452  1.00  6.08   A
ATOM   5711  O   PHE A  98      36.168  51.789  76.839  1.00  6.41   A
ATOM   5712  N   MET A  99      37.896  52.490  75.589  1.00  6.17   A
ATOM   5713  CA  MET A  99      38.146  51.152  75.062  1.00  5.91   A
ATOM   5714  CB  MET A  99      39.330  51.155  74.091  1.00  7.58   A
ATOM   5715  CG  MET A  99      39.159  52.043  72.860  1.00  7.35   A
ATOM   5716  SD  MET A  99      37.673  51.709  71.886  1.00  7.56   A
ATOM   5717  CE  MET A  99      38.136  50.177  71.036  1.00  9.56   A
ATOM   5718  C   MET A  99      38.439  50.178  76.198  1.00  6.10   A
ATOM   5719  O   MET A  99      38.060  49.005  76.139  1.00  7.35   A
ATOM   5720  N   SER A 100      39.108  50.671  77.236  1.00  6.09   A
ATOM   5721  CA  SER A 100      39.465  49.839  78.382  1.00  8.79   A
ATOM   5722  CB  SER A 100      40.533  50.546  79.220  1.00  9.54   A
ATOM   5723  OG  SER A 100      41.722  50.717  78.466  1.00 15.41   A
ATOM   5724  C   SER A 100      38.279  49.449  79.266  1.00  9.77   A
ATOM   5725  O   SER A 100      38.415  48.591  80.142  1.00 12.78   A
ATOM   5726  N   CYS A 101      37.123  50.067  79.033  1.00  9.75   A
ATOM   5727  CA  CYS A 101      35.920  49.764  79.808  1.00 11.59   A
ATOM   5728  CB  CYS A 101      34.892  50.892  79.680  1.00 12.49   A
ATOM   5729  SG  CYS A 101      35.263  52.370  80.617  1.00 15.69   A
ATOM   5730  C   CYS A 101      35.260  48.469  79.351  1.00 10.47   A
ATOM   5731  O   CYS A 101      34.497  47.857  80.100  1.00 12.82   A
ATOM   5732  N   PHE A 102      35.542  48.063  78.119  1.00 10.24   A
ATOM   5733  CA  PHE A 102      34.941  46.855  77.571  1.00 10.36   A
ATOM   5734  CB  PHE A 102      35.009  46.877  76.045  1.00 10.28   A
ATOM   5735  CG  PHE A 102      34.151  47.936  75.420  1.00  8.84   A
ATOM   5736  CD1 PHE A 102      34.567  49.263  75.386  1.00  9.33   A
ATOM   5737  CD2 PHE A 102      32.910  47.609  74.884  1.00  9.36   A
ATOM   5738  CE1 PHE A 102      33.756  50.251  74.829  1.00  8.74   A
ATOM   5739  CE2 PHE A 102      32.092  48.586  74.325  1.00  9.38   A
ATOM   5740  CZ  PHE A 102      32.516  49.911  74.297  1.00  7.96   A
ATOM   5741  C   PHE A 102      35.581  45.577  78.097  1.00 11.75   A
ATOM   5742  O   PHE A 102      36.801  45.487  78.213  1.00 12.38   A
ATOM   5743  N   PRO A 103      34.755  44.566  78.420  1.00 12.10   A
ATOM   5744  CD  PRO A 103      33.282  44.633  78.463  1.00 12.55   A
ATOM   5745  CA  PRO A 103      35.232  43.278  78.937  1.00 13.72   A
ATOM   5746  CB  PRO A 103      34.005  42.730  79.650  1.00 14.58   A
ATOM   5747  CG  PRO A 103      32.898  43.194  78.758  1.00 13.49   A
ATOM   5748  C   PRO A 103      35.709  42.361  77.815  1.00 14.61   A
ATOM   5749  O   PRO A 103      35.101  41.325  77.544  1.00 15.36   A
ATOM   5750  N   TRP A 104      36.804  42.744  77.171  1.00 14.45   A
ATOM   5751  CA  TRP A 104      37.352  41.968  76.068  1.00 15.73   A
ATOM   5752  CB  TRP A 104      38.617  42.634  75.529  1.00 15.71   A
ATOM   5753  CG  TRP A 104      38.438  44.071  75.158  1.00 13.26   A
ATOM   5754  CD2 TRP A 104      37.817  44.572  73.972  1.00 13.03   A
ATOM   5755  CE2 TRP A 104      37.825  45.981  74.063  1.00 11.27   A
ATOM   5756  CE3 TRP A 104      37.242  43.965  72.848  1.00 12.96   A
ATOM   5757  CD1 TRP A 104      38.797  45.163  75.895  1.00 12.87   A
ATOM   5758  NE1 TRP A 104      38.433  46.315  75.242  1.00 11.57   A
ATOM   5759  CZ2 TRP A 104      37.288  46.796  73.060  1.00 13.14   A
ATOM   5760  CZ3 TRP A 104      36.707  44.776  71.853  1.00 13.80   A
ATOM   5761  CH2 TRP A 104      36.731  46.176  71.970  1.00 14.33   A
ATOM   5762  C   TRP A 104      37.670  40.516  76.424  1.00 17.38   A
ATOM   5763  O   TRP A 104      37.534  39.628  75.591  1.00 18.27   A
ATOM   5764  N   ALA A 105      38.088  40.265  77.658  1.00 18.99   A
ATOM   5765  CA  ALA A 105      38.443  38.907  78.053  1.00 21.60   A
ATOM   5766  CB  ALA A 105      39.670  38.942  78.956  1.00 21.34   A
ATOM   5767  C   ALA A 105      37.330  38.111  78.726  1.00 23.19   A
ATOM   5768  O   ALA A 105      37.545  36.968  79.130  1.00 23.27   A
ATOM   5769  N   GLU A 106      36.144  38.700  78.843  1.00 24.01   A
ATOM   5770  CA  GLU A 106      35.028  38.009  79.480  1.00 25.35   A
ATOM   5771  CB  GLU A 106      33.773  38.884  79.457  1.00 25.81   A
ATOM   5772  CG  GLU A 106      32.545  38.207  80.053  1.00 26.97   A
ATOM   5773  CD  GLU A 106      32.799  37.651  81.443  1.00 27.81   A
ATOM   5774  OE1 GLU A 106      33.119  38.441  82.356  1.00 28.08   A
ATOM   5775  OE2 GLU A 106      32.681  36.419  81.620  1.00 28.82   A
ATOM   5776  C   GLU A 106      34.735  36.666  78.819  1.00 25.88   A
ATOM   5777  O   GLU A 106      34.530  36.582  77.609  1.00 25.18   A
ATOM   5778  N   LYS A 107      34.713  35.618  79.637  1.00 27.20   A
ATOM   5779  CA  LYS A 107      34.462  34.255  79.179  1.00 28.80   A
ATOM   5780  CB  LYS A 107      34.794  33.252  80.292  1.00 29.93   A
ATOM   5781  CG  LYS A 107      36.017  33.600  81.132  1.00 31.92   A
ATOM   5782  CD  LYS A 107      35.769  34.840  81.986  1.00 33.29   A
ATOM   5783  CE  LYS A 107      36.998  35.235  82.776  1.00 35.16   A
ATOM   5784  NZ  LYS A 107      36.888  36.631  83.286  1.00 36.27   A
ATOM   5785  C   LYS A 107      33.000  34.085  78.779  1.00 28.48   A
ATOM   5786  O   LYS A 107      32.693  33.623  77.681  1.00 29.44   A
ATOM   5787  N   LYS A 108      32.107  34.456  79.690  1.00 28.29   A
ATOM   5788  CA  LYS A 108      30.671  34.350  79.462  1.00 28.16   A
ATOM   5789  CB  LYS A 108      29.920  34.648  80.761  1.00 29.14   A
ATOM   5790  CG  LYS A 108      30.297  33.723  81.911  1.00 30.38   A
ATOM   5791  CD  LYS A 108      29.548  34.069  83.188  1.00 32.02   A
ATOM   5792  CE  LYS A 108      29.946  35.439  83.720  1.00 33.28   A
ATOM   5793  NZ  LYS A 108      31.394  35.501  84.063  1.00 34.77   A
ATOM   5794  C   LYS A 108      30.227  35.311  78.364  1.00 27.82   A
ATOM   5795  O   LYS A 108      30.147  36.521  78.576  1.00 26.75   A
ATOM   5796  N   GLN A 109      29.932  34.759  77.191  1.00 27.48   A
ATOM   5797  CA  GLN A 109      29.510  35.559  76.046  1.00 27.67   A
ATOM   5798  CB  GLN A 109      29.326  34.662  74.820  1.00 29.61   A
ATOM   5799  CG  GLN A 109      30.615  34.010  74.345  1.00 32.22   A
ATOM   5800  CD  GLN A 109      31.706  35.024  74.043  1.00 33.48   A
ATOM   5801  OE1 GLN A 109      31.559  35.869  73.161  1.00 35.21   A
ATOM   5802  NE2 GLN A 109      32.808  34.943  74.779  1.00 33.63   A
ATOM   5803  C   GLN A 109      28.238  36.362  76.290  1.00 26.71   A
ATOM   5804  O   GLN A 109      28.121  37.497  75.833  1.00 25.25   A
ATOM   5805  N   ASP A 110      27.284  35.774  77.004  1.00 26.14   A
ATOM   5806  CA  ASP A 110      26.030  36.459  77.293  1.00 25.81   A
ATOM   5807  CB  ASP A 110      25.071  35.516  78.031  1.00 28.34   A
ATOM   5808  CG  ASP A 110      25.701  34.879  79.254  1.00 30.43   A
ATOM   5809  OD1 ASP A 110      25.955  35.597  80.242  1.00 31.82   A
ATOM   5810  OD2 ASP A 110      25.945  33.654  79.226  1.00 33.72   A
ATOM   5811  C   ASP A 110      26.275  37.722  78.115  1.00 24.06   A
ATOM   5812  O   ASP A 110      25.718  38.781  77.823  1.00 23.68   A
ATOM   5813  N   VAL A 111      27.117  37.610  79.138  1.00 22.43   A
ATOM   5814  CA  VAL A 111      27.433  38.748  79.994  1.00 20.34   A
ATOM   5815  CB  VAL A 111      28.257  38.311  81.226  1.00 21.27   A
ATOM   5816  CG1 VAL A 111      28.620  39.523  82.070  1.00 22.02   A
ATOM   5817  CG2 VAL A 111      27.464  37.313  82.053  1.00 22.25   A
ATOM   5818  C   VAL A 111      28.240  39.778  79.215  1.00 18.84   A
ATOM   5819  O   VAL A 111      28.005  40.980  79.309  1.00 17.77   A
ATOM   5820  N   LYS A 112      29.195  39.292  78.442  1.00 17.36   A
ATOM   5821  CA  LYS A 112      30.048  40.154  77.650  1.00 16.73   A
ATOM   5822  CB  LYS A 112      31.037  39.287  76.919  1.00 17.64   A
ATOM   5823  CG  LYS A 112      32.075  40.014  76.182  1.00 18.95   A
ATOM   5824  CD  LYS A 112      32.954  38.942  75.717  1.00 21.64   A
ATOM   5825  CE  LYS A 112      34.038  39.471  74.948  1.00 22.51   A
ATOM   5826  NZ  LYS A 112      34.561  38.318  74.176  1.00 25.51   A
ATOM   5827  C   LYS A 112      29.242  40.977  76.656  1.00 15.52   A
ATOM   5828  O   LYS A 112      29.410  42.192  76.550  1.00 13.43   A
ATOM   5829  N   GLU A 113      28.366  40.298  75.925  1.00 14.92   A
ATOM   5830  CA  GLU A 113      27.520  40.947  74.938  1.00 15.67   A
ATOM   5831  CB  GLU A 113      26.626  39.904  74.271  1.00 18.01   A
ATOM   5832  CG  GLU A 113      25.680  40.492  73.263  1.00 23.31   A
ATOM   5833  CD  GLU A 113      24.799  39.452  72.598  1.00 25.74   A
ATOM   5834  OE1 GLU A 113      25.338  38.456  72.073  1.00 27.13   A
ATOM   5835  OE2 GLU A 113      23.565  39.642  72.587  1.00 28.97   A
ATOM   5836  C   GLU A 113      26.659  42.036  75.575  1.00 14.49   A
ATOM   5837  O   GLU A 113      26.556  43.148  75.053  1.00 13.30   A
ATOM   5838  N   GLN A 114      26.046  41.709  76.708  1.00 14.04   A
ATOM   5839  CA  GLN A 114      25.196  42.657  77.418  1.00 14.13   A
ATOM   5840  CB  GLN A 114      24.622  42.011  78.685  1.00 15.69   A
ATOM   5841  CG  GLN A 114      23.799  42.961  79.545  1.00 18.28   A
ATOM   5842  CD  GLN A 114      22.512  43.407  78.874  1.00 19.74   A
ATOM   5843  OE1 GLN A 114      21.856  44.344  79.330  1.00 23.56   A
ATOM   5844  NE2 GLN A 114      22.140  42.733  77.792  1.00 21.05   A
ATOM   5845  C   GLN A 114      25.966  43.920  77.793  1.00 13.10   A
ATOM   5846  O   GLN A 114      25.486  45.033  77.583  1.00 12.07   A
ATOM   5847  N   MET A 115      27.161  43.744  78.347  1.00 12.86   A
ATOM   5848  CA  MET A 115      27.986  44.876  78.750  1.00 11.47   A
ATOM   5849  CB  MET A 115      29.219  44.375  79.516  1.00 14.17   A
ATOM   5850  CG  MET A 115      30.295  45.433  79.785  1.00 19.50   A
ATOM   5851  SD  MET A 115      31.315  45.040  81.253  1.00 26.29   A
ATOM   5852  CE  MET A 115      31.200  46.546  82.323  1.00 25.88   A
ATOM   5853  C   MET A 115      28.398  45.721  77.546  1.00 10.85   A
ATOM   5854  O   MET A 115      28.364  46.951  77.602  1.00 10.44   A
ATOM   5855  N   PHE A 116      28.786  45.063  76.458  1.00 10.25   A
ATOM   5856  CA  PHE A 116      29.172  45.783  75.249  1.00  9.42   A
ATOM   5857  CB  PHE A 116      29.552  44.810  74.126  1.00  9.27   A
ATOM   5858  CG  PHE A 116      31.026  44.519  74.038  1.00 11.09   A
ATOM   5859  CD1 PHE A 116      31.687  43.865  75.070  1.00 10.32   A
ATOM   5860  CD2 PHE A 116      31.749  44.897  72.912  1.00 12.11   A
ATOM   5861  CE1 PHE A 116      33.053  43.589  74.985  1.00 12.71   A
ATOM   5862  CE2 PHE A 116      33.113  44.629  72.814  1.00 11.83   A
ATOM   5863  CZ  PHE A 116      33.766  43.972  73.853  1.00 11.75   A
ATOM   5864  C   PHE A 116      28.013  46.652  74.772  1.00  7.94   A
ATOM   5865  O   PHE A 116      28.193  47.826  74.460  1.00  8.19   A
ATOM   6152  N   TYR A 152      44.548  57.094  66.166  1.00  5.28   A
ATOM   6153  CA  TYR A 152      43.884  56.348  67.225  1.00  4.93   A
ATOM   6154  CB  TYR A 152      44.409  56.744  68.612  1.00  5.14   A
ATOM   6155  CG  TYR A 152      44.300  55.605  69.611  1.00  5.38   A
ATOM   6156  CD1 TYR A 152      44.726  54.319  69.273  1.00  6.68   A
ATOM   6157  CE1 TYR A 152      44.646  53.268  70.177  1.00  6.58   A
ATOM   6158  CD2 TYR A 152      43.784  55.806  70.888  1.00  4.95   A
ATOM   6159  CE2 TYR A 152      43.702  54.755  71.804  1.00  4.84   A
ATOM   6160  CZ  TYR A 152      44.136  53.492  71.439  1.00  5.18   A
ATOM   6161  OH  TYR A 152      44.081  52.443  72.330  1.00  6.87   A
ATOM   6162  C   TYR A 152      42.372  56.492  67.156  1.00  5.08   A
ATOM   6163  O   TYR A 152      41.647  55.557  67.485  1.00  5.51   A
ATOM   6164  N   TRP A 153      41.884  57.656  66.736  1.00  5.39   A
ATOM   6165  CA  TRP A 153      40.442  57.818  66.600  1.00  5.76   A
ATOM   6166  CB  TRP A 153      40.073  59.242  66.171  1.00  5.97   A
ATOM   6167  CG  TRP A 153      38.665  59.325  65.648  1.00  5.87   A
ATOM   6168  CD2 TRP A 153      37.471  58.920  66.332  1.00  5.91   A
ATOM   6169  CE2 TRP A 153      36.396  59.086  65.429  1.00  5.96   A
ATOM   6170  CE3 TRP A 153      37.207  58.420  67.615  1.00  6.22   A
ATOM   6171  CD1 TRP A 153      38.274  59.723  64.399  1.00  7.17   A
ATOM   6172  NE1 TRP A 153      36.912  59.582  64.261  1.00  7.77   A
ATOM   6173  CZ2 TRP A 153      35.072  58.781  65.772  1.00  6.91   A
ATOM   6174  CZ3 TRP A 153      35.886  58.116  67.956  1.00  7.15   A
ATOM   6175  CH2 TRP A 153      34.839  58.294  67.032  1.00  7.76   A
ATOM   6176  C   TRP A 153      39.930  56.835  65.546  1.00  5.37   A
ATOM   6177  O   TRP A 153      38.934  56.144  65.756  1.00  5.17   A
ATOM   6178  N   GLU A 154      40.611  56.772  64.406  1.00  5.96   A
ATOM   6179  CA  GLU A 154      40.176  55.877  63.343  1.00  5.72   A
ATOM   6180  CB  GLU A 154      41.009  56.110  62.079  1.00  6.13   A
ATOM   6181  CG  GLU A 154      40.449  55.429  60.833  1.00  6.44   A
ATOM   6182  CD  GLU A 154      40.878  53.979  60.703  1.00  6.70   A
ATOM   6183  OE1 GLU A 154      40.229  53.235  59.938  1.00  8.97   A
ATOM   6184  OE2 GLU A 154      41.876  53.586  61.345  1.00  8.06   A
ATOM   6185  C   GLU A 154      40.247  54.414  63.774  1.00  5.12   A
ATOM   6186  O   GLU A 154      39.355  53.625  63.467  1.00  6.20   A
ATOM   6187  N   ILE A 155      41.305  54.059  64.497  1.00  5.18   A
ATOM   6188  CA  ILE A 155      41.489  52.696  64.975  1.00  4.86   A
ATOM   6189  CB  ILE A 155      42.901  52.549  65.580  1.00  5.47   A
ATOM   6190  CG2 ILE A 155      42.987  51.319  66.475  1.00  6.67   A
ATOM   6191  CG1 ILE A 155      43.925  52.501  64.440  1.00  5.20   A
ATOM   6192  CD1 ILE A 155      45.357  52.705  64.879  1.00  6.49   A
ATOM   6193  C   ILE A 155      40.413  52.296  65.987  1.00  5.58   A
ATOM   6194  O   ILE A 155      39.780  51.247  65.851  1.00  5.20   A
ATOM   6195  N   CYS A 156      40.196  53.136  66.992  1.00  4.65   A
ATOM   6196  CA  CYS A 156      39.190  52.838  68.007  1.00  5.13   A
ATOM   6197  CB  CYS A 156      39.216  53.888  69.121  1.00  5.71   A
ATOM   6198  SG  CYS A 156      40.667  53.829  70.192  1.00  6.49   A
ATOM   6199  C   CYS A 156      37.789  52.779  67.420  1.00  5.66   A
ATOM   6200  O   CYS A 156      37.026  51.855  67.710  1.00  6.21   A
ATOM   6201  N   SER A 157      37.448  53.766  66.594  1.00  6.00   A
ATOM   6202  CA  SER A 157      36.114  53.797  66.009  1.00  5.99   A
ATOM   6203  CB  SER A 157      35.843  55.146  65.317  1.00  6.89   A
ATOM   6204  OG  SER A 157      36.766  55.420  64.282  1.00  6.66   A
ATOM   6205  C   SER A 157      35.868  52.633  65.053  1.00  6.25   A
ATOM   6206  O   SER A 157      34.746  52.146  64.952  1.00  6.68   A
ATOM   6207  N   THR A 158      36.902  52.170  64.358  1.00  6.04   A
ATOM   6208  CA  THR A 158      36.717  51.043  63.452  1.00  6.77   A
ATOM   6209  CB  THR A 158      38.027  50.693  62.720  1.00  7.66   A
ATOM   6210  OG1 THR A 158      38.194  51.589  61.617  1.00  8.90   A
ATOM   6211  CG2 THR A 158      38.004  49.253  62.214  1.00  8.99   A
ATOM   6212  C   THR A 158      36.219  49.827  64.225  1.00  7.46   A
ATOM   6213  O   THR A 158      35.299  49.137  63.792  1.00  7.44   A
ATOM   6214  N   THR A 159      36.813  49.572  65.380  1.00  6.82   A
ATOM   6215  CA  THR A 159      36.400  48.428  66.174  1.00  8.47   A
ATOM   6216  CB  THR A 159      37.480  48.070  67.201  1.00  8.32   A
ATOM   6217  OG1 THR A 159      38.641  47.615  66.494  1.00  9.56   A
ATOM   6218  CG2 THR A 159      37.005  46.971  68.140  1.00  8.90   A
ATOM   6219  C   THR A 159      35.049  48.651  66.849  1.00  7.49   A
ATOM   6220  O   THR A 159      34.222  47.740  66.900  1.00  8.33   A
ATOM   6221  N   LEU A 160      34.804  49.857  67.354  1.00  6.78   A
ATOM   6222  CA  LEU A 160      33.519  50.125  67.988  1.00  6.38   A
ATOM   6223  CB  LEU A 160      33.498  51.531  68.588  1.00  6.84   A
ATOM   6224  CG  LEU A 160      34.480  51.773  69.736  1.00  8.63   A
ATOM   6225  CD1 LEU A 160      34.360  53.209  70.217  1.00 11.20   A
ATOM   6226  CD2 LEU A 160      34.194  50.799  70.871  1.00 11.27   A
ATOM   6227  C   LEU A 160      32.384  49.979  66.974  1.00  7.24   A
ATOM   6228  O   LEU A 160      31.300  49.503  67.311  1.00  7.48   A
ATOM   6229  N   LEU A 161      32.642  50.383  65.733  1.00  6.66   A
ATOM   6230  CA  LEU A 161      31.641  50.297  64.673  1.00  8.42   A
ATOM   6231  CB  LEU A 161      32.156  50.972  63.403  1.00  9.08   A
ATOM   6232  CG  LEU A 161      32.054  52.499  63.404  1.00  8.17   A
ATOM   6233  CD1 LEU A 161      32.903  53.074  62.283  1.00  9.90   A
ATOM   6234  CD2 LEU A 161      30.594  52.915  63.251  1.00  9.54   A
ATOM   6235  C   LEU A 161      31.232  48.862  64.366  1.00  8.60   A
ATOM   6236  O   LEU A 161      30.132  48.619  63.874  1.00  9.07   A
ATOM   6237  N   VAL A 162      32.116  47.914  64.652  1.00  8.54   A
ATOM   6238  CA  VAL A 162      31.806  46.511  64.421  1.00 10.19   A
ATOM   6239  CB  VAL A 162      33.025  45.605  64.724  1.00  9.33   A
ATOM   6240  CG1 VAL A 162      32.617  44.139  64.661  1.00 12.54   A
ATOM   6241  CG2 VAL A 162      34.147  45.883  63.735  1.00 10.70   A
ATOM   6242  C   VAL A 162      30.656  46.102  65.337  1.00 10.61   A
ATOM   6243  O   VAL A 162      29.756  45.367  64.933  1.00 12.29   A
ATOM   6244  N   PHE A 163      30.685  46.593  66.574  1.00  9.62   A
ATOM   6245  CA  PHE A 163      29.657  46.250  67.550  1.00  9.97   A
ATOM   6246  CB  PHE A 163      30.284  46.124  68.940  1.00 10.40   A
ATOM   6247  CG  PHE A 163      31.388  45.111  69.010  1.00 13.43   A
ATOM   6248  CD1 PHE A 163      32.699  45.461  68.698  1.00 14.97   A
ATOM   6249  CD2 PHE A 163      31.112  43.796  69.360  1.00 16.10   A
ATOM   6250  CE1 PHE A 163      33.718  44.511  68.735  1.00 16.79   A
ATOM   6251  CE2 PHE A 163      32.118  42.846  69.398  1.00 17.88   A
ATOM   6252  CZ  PHE A 163      33.428  43.199  69.086  1.00 18.31   A
ATOM   6253  C   PHE A 163      28.476  47.214  67.605  1.00  9.96   A
ATOM   6254  O   PHE A 163      27.414  46.865  68.116  1.00 10.98   A
ATOM   6528  N   THR A 197      41.100  40.642  60.451  1.00  6.55   A
ATOM   6529  CA  THR A 197      40.708  40.042  61.711  1.00  6.54   A
ATOM   6530  CB  THR A 197      41.867  40.118  62.727  1.00  7.01   A
ATOM   6531  OG1 THR A 197      42.283  41.481  62.890  1.00  6.91   A
ATOM   6532  CG2 THR A 197      43.048  39.300  62.229  1.00  7.77   A
ATOM   6533  C   THR A 197      39.489  40.776  62.251  1.00  6.16   A
ATOM   6534  O   THR A 197      39.252  41.929  61.910  1.00  7.50   A
ATOM   6535  N   LYS A 198      38.708  40.110  63.091  1.00  7.12   A
ATOM   6536  CA  LYS A 198      37.522  40.742  63.647  1.00  7.25   A
ATOM   6537  CB  LYS A 198      36.729  39.729  64.481  1.00  9.37   A
ATOM   6538  CG  LYS A 198      35.536  40.316  65.222  1.00 12.51   A
ATOM   6539  CD  LYS A 198      34.529  40.978  64.294  1.00 16.24   A
ATOM   6540  CE  LYS A 198      33.878  39.974  63.358  1.00 16.57   A
ATOM   6541  NZ  LYS A 198      32.726  40.573  62.615  1.00 16.81   A
ATOM   6542  C   LYS A 198      37.910  41.945  64.507  1.00  7.23   A
ATOM   6543  O   LYS A 198      37.377  43.043  64.331  1.00  8.34   A
ATOM   6544  N   LEU A 199      38.853  41.729  65.419  1.00  7.65   A
ATOM   6545  CA  LEU A 199      39.316  42.775  66.325  1.00  7.68   A
ATOM   6546  CB  LEU A 199      39.247  42.283  67.772  1.00 10.39   A
ATOM   6547  CG  LEU A 199      37.902  41.731  68.242  1.00 12.70   A
ATOM   6548  CD1 LEU A 199      38.057  41.197  69.652  1.00 15.45   A
ATOM   6549  CD2 LEU A 199      36.837  42.817  68.182  1.00 14.13   A
ATOM   6550  C   LEU A 199      40.735  43.235  66.028  1.00  7.07   A
ATOM   6551  OT1 LEU A 199      41.384  42.659  65.131  1.00  7.11   A
ATOM   6552  OT2 LEU A 199      41.186  44.168  66.721  1.00  8.05   A
ATOM   6613  N1  GSH H 200      47.240  49.426  78.365  1.00  5.76   H
ATOM   6614  CA1 GSH H 200      48.071  48.329  77.882  1.00  6.49   H
ATOM   6615  C1  GSH H 200      48.552  48.593  76.433  1.00  5.96   H
ATOM   6616  O11 GSH H 200      47.961  49.446  75.764  1.00  6.16   H
ATOM   6617  O12 GSH H 200      49.623  47.939  76.023  1.00  5.89   H
ATOM   6618  CB1 GSH H 200      47.193  47.058  77.940  1.00  7.07   H
ATOM   6619  CG1 GSH H 200      47.971  45.743  77.668  1.00  7.43   H
ATOM   6620  CD1 GSH H 200      46.947  44.584  77.671  1.00  7.37   H
ATOM   6621  OE1 GSH H 200      46.223  44.381  78.652  1.00  7.91   H
ATOM   6622  N2  GSH H 200      47.074  43.729  76.649  1.00  6.87   H
ATOM   6623  CA2 GSH H 200      46.310  42.477  76.623  1.00  6.95   H
ATOM   6624  C2  GSH H 200      47.130  41.349  77.273  1.00  8.08   H
ATOM   6625  O2  GSH H 200      48.345  41.290  77.178  1.00  8.04   H
ATOM   6626  CB2 GSH H 200      46.025  42.056  75.164  1.00  7.00   H
ATOM   6627  SG2 GSH H 200      44.867  43.164  74.287  1.00  8.63   H
ATOM   6628  N3  GSH H 200      46.473  40.585  78.154  1.00 10.11   H
ATOM   6629  CA3 GSH H 200      47.063  39.404  78.824  1.00 12.26   H
ATOM   6630  C3  GSH H 200      46.455  39.280  80.221  1.00 14.36   H
ATOM   6631  O31 GSH H 200      46.823  38.312  80.902  1.00 17.27   H
ATOM   6632  O32 GSH H 200      45.621  40.144  80.600  1.00 17.25   H
ATOM   6677  OH2 WAT S   1      45.932  55.216  78.140  1.00 11.00   S
ATOM   6678  OH2 WAT S   2      44.001  53.704  79.474  1.00  8.61   S
ATOM   6679  OH2 WAT S   3      45.044  54.147  82.027  1.00  9.47   S
ATOM   6680  OH2 WAT S   4      47.066  56.184  80.641  1.00 11.51   S
ATOM   6681  OH2 WAT S   5      44.400  56.542  80.238  1.00  6.66   S
ATOM   6682  OH2 WAT S   6      46.942  53.261  80.035  1.00  7.38   S
ATOM   6689  OH2 WAT S  13      44.802  42.314  61.828  1.00  6.00   S
ATOM   6692  OH2 WAT S  16      46.602  44.435  61.593  1.00  6.08   S
ATOM   6693  OH2 WAT S  17      51.844  46.380  76.801  1.00  5.53   S
ATOM   6694  OH2 WAT S  18      46.016  50.205  68.769  1.00  4.93   S
ATOM   6697  OH2 WAT S  21      46.289  50.659  71.607  1.00  6.24   S
ATOM   6699  OH2 WAT S  23      51.226  46.303  81.832  1.00  7.26   S
ATOM   6701  OH2 WAT S  25      49.891  52.595  76.855  1.00  6.35   S
ATOM   6702  OH2 WAT S  26      52.165  42.023  65.879  1.00  6.86   S
ATOM   6703  OH2 WAT S  27      54.167  43.535  79.506  1.00  6.85   S
ATOM   6714  OH2 WAT S  38      47.233  52.192  77.524  1.00  8.27   S
ATOM   6718  OH2 WAT S  42      48.563  46.768  84.725  1.00  8.57   S
ATOM   6719  OH2 WAT S  43      58.660  41.683  70.327  1.00  7.93   S
ATOM   6733  OH2 WAT S  57      48.526  46.955  81.917  1.00  7.89   S
ATOM   6748  OH2 WAT S  72      39.916  39.195  66.189  1.00 12.20   S
ATOM   6762  OH2 WAT S  88      52.225  56.098  78.210  1.00 11.05   S
ATOM   6783  OH2 WAT S 109      41.879  49.920  62.315  1.00  9.83   S
ATOM   6784  OH2 WAT S 110      41.843  43.595  60.246  1.00  7.19   S
ATOM   6788  OH2 WAT S 114      50.291  44.524  83.978  1.00 11.55   S
ATOM   6791  OH2 WAT S 117      45.204  49.983  75.259  1.00 11.59   S
ATOM   6794  OH2 WAT S 121      36.093  43.586  61.844  1.00 10.06   S
ATOM   6812  OH2 WAT S 140      46.502  35.525  67.908  1.00 16.03   S
ATOM   6818  OH2 WAT S 146      46.548  45.276  81.207  1.00 11.87   S
ATOM   6848  OH2 WAT S 177      47.305  35.643  80.850  1.00 15.13   S
ATOM   6851  OH2 WAT S 180      42.393  49.873  82.928  1.00 14.77   S
ATOM   6888  OH2 WAT S 219      49.260  57.057  77.605  1.00 11.44   S
ATOM   6894  OH2 WAT S 225      39.600  37.346  63.532  1.00 14.35   S
ATOM   6908  OH2 WAT S 239      44.676  42.614  80.064  1.00 17.81   S
ATOM   6923  OH2 WAT S 256      51.755  42.823  85.972  1.00 15.23   S
ATOM   6936  OH2 WAT S 269      43.744  50.995  80.612  1.00 22.66   S
ATOM   6977  OH2 WAT S 310      41.854  37.441  65.183  1.00 14.71   S
ATOM   6988  OH2 WAT S 321      52.715  31.754  68.251  1.00 25.02   S
ATOM   7004  OH2 WAT S 338      47.955  36.940  60.191  1.00 23.06   S
ATOM   7020  OH2 WAT S 356      52.697  38.727  84.915  1.00 25.89   S
ATOM   7035  OH2 WAT S 371      52.695  46.000  79.504  1.00  6.20   S
ATOM   7044  OH2 WAT S 380      45.939  45.946  85.168  1.00 15.59   S
ATOM   7069  OH2 WAT S 409      58.139  37.692  70.855  1.00 19.42   S
ATOM   7121  OH2 WAT S 463      44.454  49.864  78.620  1.00 17.85   S
ATOM   7141  OH2 WAT S 486      38.783  46.154  59.815  1.00 18.01   S
ATOM   7185  OH2 WAT S 533      55.398  32.865  68.634  1.00 26.34   S
ATOM   7218  OH2 WAT S 568      39.362  52.746  81.658  1.00 20.82   S
ATOM   7276  OH2 WAT S 630      54.033  36.951  83.283  1.00 30.87   S
ATOM   7291  OH2 WAT S 647      59.120  37.414  73.286  1.00 30.13   S
ATOM   7297  OH2 WAT S 653      43.339  48.112  81.026  1.00 26.20   S
ATOM   7315  OH2 WAT S 677      41.879  54.425  82.374  1.00 22.86   S
ATOM   7345  OH2 WAT S 707      49.594  41.237  85.951  1.00 26.42   S
ATOM   7396  OH2 WAT S 760      33.326  48.774  82.446  1.00 41.01   S
ATOM   7397  OH2 WAT S 761      44.428  46.156  82.727  1.00 21.46   S
ATOM   7432  OH2 WAT S 798      37.760  35.933  64.870  1.00 24.86   S
ATOM   7447  OH2 WAT S 815      44.586  33.922  63.810  1.00 27.17   S
ATOM   7451  OH2 WAT S 819      42.590  49.990  76.103  1.00 37.29   S
ATOM   7491  OH2 WAT S 865      49.313  34.257  64.053  1.00 23.25   S
ATOM   7551  OH2 WAT S 936      38.403  45.727  86.224  1.00 34.77   S
ATOM   7559  OH2 WAT S 947      39.267  36.269  81.440  1.00 35.93   S
ATOM   7562  OH2 WAT S 950      46.311  34.424  83.694  1.00 37.47   S
ATOM   7566  OH2 WAT S 954      49.354  35.076  61.559  1.00 34.30   S
ATOM   7573  OH2 WAT S 962      41.074  48.947  64.727  1.00  6.62   S
ATOM   7576  OH2 WAT S 965      42.360  48.144  66.991  1.00  8.16   S
ATOM   7580  OH2 WAT S 969      40.070  46.736  70.359  1.00 15.63   S
ATOM   7581  OH2 WAT S 970      40.472  46.466  67.816  1.00 11.14   S
ATOM   7584  OH2 WAT S 974      46.488  28.447  69.078  1.00 22.47   S
ATOM   7664  OH2 WAT S1104      49.140  39.068  82.273  1.00 19.35   S
ATOM   7673  OH2 WAT S1117      49.385  36.341  85.538  1.00 28.59   S
ATOM   7675  OH2 WAT S1119      41.071  46.806  79.458  1.00 26.70   S
ATOM   7676  OH2 WAT S1120      38.224  37.620  67.988  1.00 32.98   S
ATOM   7678  OH2 WAT S1123      41.996  35.058  66.930  1.00 32.93   S
ATOM   7683  OH2 WAT S1129      47.152  42.956  85.367  1.00 37.94   S
ATOM   7722  OH2 WAT S1180      36.068  36.649  75.341  1.00 43.94   S
ATOM   7732  OH2 WAT S1191      42.482  52.407  81.689  1.00 21.38   S
ATOM   7733  OH2 WAT S1192      39.535  50.355  82.874  1.00 32.24   S
ATOM   7737  OH2 WAT S1196      50.213  38.953  84.774  1.00 27.44   S
ATOM   7843  OH2 WAT S1339      35.818  45.711  82.635  1.00 44.01   S
ATOM   7853  OH2 WAT S1354      46.962  39.117  87.092  1.00 36.93   S
ATOM   7874  OH2 WAT S1383      32.545  41.137  82.654  1.00 33.68   S
ATOM   7884  OH2 WAT S1401      45.736  37.693  83.360  1.00 44.69   S
ATOM   7926  OH2 WAT S1447      45.667  30.953  67.849  1.00 35.68   S
ATOM   7927  OH2 WAT S1448      55.702  38.128  82.442  1.00 36.01   S
ATOM   7948  OH2 WAT S1474      44.404  43.677  86.488  1.00 42.40   S
ATOM   7952  OH2 WAT S1480      40.448  40.603  87.707  1.00 38.53   S
ATOM   7954  OH2 WAT S1482      48.226  42.042  87.524  1.00 41.24   S
ATOM   7996  OH2 WAT S1530      41.155  35.723  62.708  1.00 35.51   S
ATOM   8019  OH2 WAT S1558      44.128  34.781  68.900  1.00 42.94   S
ATOM   8020  OH2 WAT S1559      43.571  35.946  71.823  1.00 42.74   S
ATOM   8127  C1  U46 X 201      41.871  38.419  75.254  1.00 41.44   X
ATOM   8128  C2  U46 X 201      40.838  38.243  74.213  1.00 41.53   X
ATOM   8129  C3  U46 X 201      40.546  39.776  73.818  1.00 41.45   X
ATOM   8130  C4  U46 X 201      42.010  40.338  73.856  1.00 41.07   X
ATOM   8131  C5  U46 X 201      42.792  39.065  74.274  1.00 41.56   X
ATOM   8132  O6  U46 X 201      42.922  38.036  73.307  1.00 41.32   X
ATOM   8133  C7  U46 X 201      41.676  37.405  73.215  1.00 41.76   X
ATOM   8134  C14 U46 X 201      42.399  41.346  74.949  1.00 40.61   X
ATOM   8135  C16 U46 X 201      41.701  42.023  75.922  1.00 40.28   X
ATOM   8136  C18 U46 X 201      42.762  42.478  76.971  1.00 40.54   X
ATOM   8137  C20 U46 X 201      42.973  41.118  77.340  1.00 40.10   X
ATOM   8138  C21 U46 X 201      43.792  40.318  78.232  1.00 39.99   X
ATOM   8139  C24 U46 X 201      43.404  38.935  77.644  1.00 40.60   X
ATOM   8140  C27 U46 X 201      43.941  37.551  78.094  1.00 41.02   X
ATOM   8141  C30 U46 X 201      43.168  36.476  77.301  1.00 41.85   X
ATOM   8142  O36 U46 X 201      42.312  43.249  77.943  1.00 40.95   X
ATOM   8143  C39 U46 X 201      39.913  39.986  72.481  1.00 41.80   X
ATOM   8144  C41 U46 X 201      38.932  38.921  72.298  1.00 42.50   X
ATOM   8145  C44 U46 X 201      37.645  38.825  72.466  1.00 43.42   X
ATOM   8146  C46 U46 X 201      36.596  39.762  72.916  1.00 43.47   X
ATOM   8147  C48 U46 X 201      35.496  39.760  71.872  1.00 44.38   X
ATOM   8148  C51 U46 X 201      34.385  40.531  72.463  1.00 45.27   X
ATOM   8149  C54 U46 X 201      33.109  40.654  71.681  1.00 45.90   X
ATOM   8150  O57 U46 X 201      32.181  41.256  72.479  1.00 46.00   X
ATOM   8151  O58 U46 X 201      32.887  40.235  70.603  1.00 46.55   X
【００５１】
【表５】
ヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２α（Ｕ４４）との複合体の３次元構造座標
ATOM   4966  N   TYR A   8      24.336  32.545  34.593  1.00 23.71   A
ATOM   4967  CA  TYR A   8      22.908  32.784  34.729  1.00 23.39   A
ATOM   4968  CB  TYR A   8      22.170  31.441  34.781  1.00 22.82   A
ATOM   4969  CG  TYR A   8      20.663  31.544  34.721  1.00 22.10   A
ATOM   4970  CD1 TYR A   8      20.024  32.094  33.606  1.00 21.74   A
ATOM   4971  CE1 TYR A   8      18.634  32.184  33.541  1.00 21.38   A
ATOM   4972  CD2 TYR A   8      19.872  31.084  35.777  1.00 21.64   A
ATOM   4973  CE2 TYR A   8      18.481  31.170  35.723  1.00 21.52   A
ATOM   4974  CZ  TYR A   8      17.872  31.721  34.602  1.00 21.33   A
ATOM   4975  OH  TYR A   8      16.504  31.801  34.542  1.00 21.12   A
ATOM   4976  C   TYR A   8      22.659  33.572  36.016  1.00 23.34   A
ATOM   4977  O   TYR A   8      23.597  33.866  36.755  1.00 23.65   A
ATOM   4978  N   PHE A   9      21.402  33.921  36.273  1.00 23.18   A
ATOM   4979  CA  PHE A   9      21.042  34.657  37.478  1.00 23.08   A
ATOM   4980  CB  PHE A   9      19.635  35.237  37.348  1.00 23.27   A
ATOM   4981  CG  PHE A   9      19.527  36.344  36.342  1.00 23.76   A
ATOM   4982  CD1 PHE A   9      18.642  36.248  35.273  1.00 23.77   A
ATOM   4983  CD2 PHE A   9      20.298  37.494  36.471  1.00 24.01   A
ATOM   4984  CE1 PHE A   9      18.524  37.286  34.346  1.00 24.05   A
ATOM   4985  CE2 PHE A   9      20.190  38.535  35.552  1.00 24.19   A
ATOM   4986  CZ  PHE A   9      19.300  38.431  34.488  1.00 24.13   A
ATOM   4987  C   PHE A   9      21.085  33.712  38.666  1.00 22.94   A
ATOM   4988  O   PHE A   9      21.182  32.497  38.491  1.00 22.79   A
ATOM   4989  N   ASN A  10      21.014  34.263  39.873  1.00 22.88   A
ATOM   4990  CA  ASN A  10      21.039  33.427  41.064  1.00 22.79   A
ATOM   4991  CB  ASN A  10      21.504  34.217  42.288  1.00 22.91   A
ATOM   4992  CG  ASN A  10      21.505  33.369  43.546  1.00 22.98   A
ATOM   4993  OD1 ASN A  10      21.877  32.191  43.508  1.00 22.82   A
ATOM   4994  ND2 ASN A  10      21.091  33.957  44.666  1.00 23.07   A
ATOM   4995  C   ASN A  10      19.674  32.817  41.345  1.00 22.64   A
ATOM   4996  O   ASN A  10      18.942  33.272  42.225  1.00 22.44   A
ATOM   4997  N   MET A  11      19.340  31.785  40.576  1.00 22.50   A
ATOM   4998  CA  MET A  11      18.080  31.070  40.723  1.00 22.24   A
ATOM   4999  CB  MET A  11      16.895  31.982  40.360  1.00 23.52   A
ATOM   5000  CG  MET A  11      17.007  32.727  39.047  1.00 24.37   A
ATOM   5001  SD  MET A  11      15.802  34.129  38.850  1.00 26.46   A
ATOM   5002  CE  MET A  11      16.836  35.517  39.396  1.00 25.81   A
ATOM   5003  C   MET A  11      18.090  29.814  39.857  1.00 21.50   A
ATOM   5004  O   MET A  11      18.967  29.645  39.006  1.00 21.28   A
ATOM   5005  N   ARG A  12      17.141  28.916  40.107  1.00 20.53   A
ATOM   5006  CA  ARG A  12      17.043  27.684  39.339  1.00 19.59   A
ATOM   5007  CB  ARG A  12      15.934  26.791  39.911  1.00 19.37   A
ATOM   5008  CG  ARG A  12      16.161  26.371  41.367  1.00 19.34   A
ATOM   5009  CD  ARG A  12      15.131  25.327  41.823  1.00 18.54   A
ATOM   5010  NE  ARG A  12      13.767  25.844  41.732  1.00 18.63   A
ATOM   5011  CZ  ARG A  12      13.276  26.789  42.524  1.00 18.61   A
ATOM   5012  NH1 ARG A  12      14.038  27.316  43.477  1.00 18.60   A
ATOM   5013  NH2 ARG A  12      12.033  27.219  42.354  1.00 18.16   A
ATOM   5014  C   ARG A  12      16.720  28.094  37.909  1.00 19.15   A
ATOM   5015  O   ARG A  12      17.536  27.922  37.003  1.00 18.76   A
ATOM   5016  N   GLY A  13      15.531  28.659  37.729  1.00 18.65   A
ATOM   5017  CA  GLY A  13      15.102  29.119  36.421  1.00 18.28   A
ATOM   5018  C   GLY A  13      15.414  28.194  35.262  1.00 18.14   A
ATOM   5019  O   GLY A  13      15.277  26.972  35.366  1.00 17.63   A
ATOM   5020  N   ARG A  14      15.863  28.793  34.162  1.00 17.96   A
ATOM   5021  CA  ARG A  14      16.177  28.069  32.933  1.00 18.29   A
ATOM   5022  CB  ARG A  14      16.047  29.022  31.738  1.00 18.89   A
ATOM   5023  CG  ARG A  14      14.666  29.644  31.606  1.00 19.92   A
ATOM   5024  CD  ARG A  14      14.549  30.514  30.365  1.00 21.37   A
ATOM   5025  NE  ARG A  14      13.164  30.648  29.917  1.00 22.61   A
ATOM   5026  CZ  ARG A  14      12.361  31.673  30.191  1.00 23.60   A
ATOM   5027  NH1 ARG A  14      11.110  31.677  29.727  1.00 24.26   A
ATOM   5028  NH2 ARG A  14      12.799  32.701  30.906  1.00 23.64   A
ATOM   5029  C   ARG A  14      17.552  27.412  32.912  1.00 18.18   A
ATOM   5030  O   ARG A  14      17.885  26.703  31.970  1.00 18.06   A
ATOM   5031  N   ALA A  15      18.355  27.634  33.943  1.00 18.06   A
ATOM   5032  CA  ALA A  15      19.680  27.027  33.964  1.00 18.18   A
ATOM   5033  CB  ALA A  15      20.689  27.991  34.579  1.00 18.24   A
ATOM   5034  C   ALA A  15      19.694  25.710  34.735  1.00 18.01   A
ATOM   5035  O   ALA A  15      20.576  24.875  34.541  1.00 17.87   A
ATOM   5036  N   GLU A  16      18.712  25.520  35.607  1.00 18.14   A
ATOM   5037  CA  GLU A  16      18.671  24.313  36.426  1.00 17.94   A
ATOM   5038  CB  GLU A  16      17.412  24.314  37.295  1.00 18.23   A
ATOM   5039  CG  GLU A  16      17.518  23.451  38.545  1.00 18.77   A
ATOM   5040  CD  GLU A  16      18.639  23.897  39.478  1.00 19.23   A
ATOM   5041  OE1 GLU A  16      19.109  25.046  39.354  1.00 19.68   A
ATOM   5042  OE2 GLU A  16      19.043  23.099  40.349  1.00 19.82   A
ATOM   5043  C   GLU A  16      18.774  22.991  35.653  1.00 17.71   A
ATOM   5044  O   GLU A  16      19.443  22.063  36.102  1.00 17.63   A
ATOM   5045  N   ILE A  17      18.124  22.900  34.497  1.00 17.52   A
ATOM   5046  CA  ILE A  17      18.176  21.667  33.715  1.00 17.48   A
ATOM   5047  CB  ILE A  17      17.312  21.776  32.436  1.00 17.22   A
ATOM   5048  CG2 ILE A  17      17.790  22.941  31.585  1.00 17.01   A
ATOM   5049  CG1 ILE A  17      17.366  20.462  31.652  1.00 17.08   A
ATOM   5050  CD1 ILE A  17      16.797  19.262  32.406  1.00 17.66   A
ATOM   5051  C   ILE A  17      19.611  21.316  33.330  1.00 17.59   A
ATOM   5052  O   ILE A  17      19.977  20.143  33.255  1.00 17.72   A
ATOM   5242  N   TRP A  39      24.145  42.736  35.174  1.00 42.17   A
ATOM   5243  CA  TRP A  39      23.529  42.160  33.983  1.00 41.90   A
ATOM   5244  CB  TRP A  39      22.062  41.812  34.261  1.00 41.67   A
ATOM   5245  CG  TRP A  39      21.310  41.341  33.047  1.00 41.34   A
ATOM   5246  CD2 TRP A  39      21.735  40.353  32.097  1.00 41.24   A
ATOM   5247  CE2 TRP A  39      20.708  40.233  31.133  1.00 41.24   A
ATOM   5248  CE3 TRP A  39      22.881  39.559  31.967  1.00 41.17   A
ATOM   5249  CD1 TRP A  39      20.082  41.765  32.632  1.00 41.33   A
ATOM   5250  NE1 TRP A  39      19.713  41.106  31.484  1.00 41.21   A
ATOM   5251  CZ2 TRP A  39      20.794  39.348  30.051  1.00 41.18   A
ATOM   5252  CZ3 TRP A  39      22.967  38.678  30.891  1.00 41.18   A
ATOM   5253  CH2 TRP A  39      21.927  38.582  29.947  1.00 41.22   A
ATOM   5254  C   TRP A  39      23.610  43.095  32.774  1.00 41.82   A
ATOM   5255  O   TRP A  39      23.990  42.678  31.681  1.00 41.83   A
ATOM   5256  N   PRO A  40      23.253  44.376  32.956  1.00 41.74   A
ATOM   5257  CD  PRO A  40      22.790  45.032  34.194  1.00 41.72   A
ATOM   5258  CA  PRO A  40      23.299  45.335  31.850  1.00 41.61   A
ATOM   5259  CB  PRO A  40      23.085  46.672  32.553  1.00 41.71   A
ATOM   5260  CG  PRO A  40      22.158  46.304  33.670  1.00 41.78   A
ATOM   5261  C   PRO A  40      24.598  45.298  31.047  1.00 41.46   A
ATOM   5262  O   PRO A  40      24.571  45.278  29.818  1.00 41.46   A
ATOM   5263  N   GLU A  41      25.731  45.284  31.742  1.00 41.23   A
ATOM   5264  CA  GLU A  41      27.030  45.262  31.079  1.00 41.03   A
ATOM   5265  CB  GLU A  41      28.147  45.542  32.088  1.00 41.50   A
ATOM   5266  CG  GLU A  41      27.983  46.835  32.868  1.00 42.28   A
ATOM   5267  CD  GLU A  41      26.844  46.776  33.870  1.00 42.66   A
ATOM   5268  OE1 GLU A  41      26.899  45.926  34.783  1.00 42.97   A
ATOM   5269  OE2 GLU A  41      25.895  47.579  33.746  1.00 43.13   A
ATOM   5270  C   GLU A  41      27.301  43.929  30.391  1.00 40.57   A
ATOM   5271  O   GLU A  41      27.795  43.889  29.265  1.00 40.56   A
ATOM   5272  N   ILE A  42      26.977  42.839  31.078  1.00 39.94   A
ATOM   5273  CA  ILE A  42      27.193  41.499  30.547  1.00 39.34   A
ATOM   5274  CB  ILE A  42      26.899  40.434  31.624  1.00 39.29   A
ATOM   5275  CG2 ILE A  42      27.163  39.043  31.071  1.00 39.27   A
ATOM   5276  CG1 ILE A  42      27.776  40.691  32.851  1.00 39.26   A
ATOM   5277  CD1 ILE A  42      27.446  39.819  34.036  1.00 39.48   A
ATOM   5278  C   ILE A  42      26.316  41.223  29.332  1.00 38.87   A
ATOM   5279  O   ILE A  42      26.780  40.678  28.331  1.00 38.77   A
ATOM   5280  N   LYS A  43      25.047  41.605  29.434  1.00 38.49   A
ATOM   5281  CA  LYS A  43      24.077  41.404  28.363  1.00 38.12   A
ATOM   5282  CB  LYS A  43      22.759  42.086  28.722  1.00 38.17   A
ATOM   5283  CG  LYS A  43      21.711  41.995  27.630  1.00 38.16   A
ATOM   5284  CD  LYS A  43      20.457  42.760  28.004  1.00 38.30   A
ATOM   5285  CE  LYS A  43      19.412  42.658  26.909  1.00 38.35   A
ATOM   5286  NZ  LYS A  43      18.211  43.462  27.231  1.00 38.78   A
ATOM   5287  C   LYS A  43      24.555  41.940  27.021  1.00 37.94   A
ATOM   5288  O   LYS A  43      24.300  41.345  25.973  1.00 37.89   A
ATOM   5328  N   GLY A  49      22.030  38.588  23.868  1.00 27.57   A
ATOM   5329  CA  GLY A  49      21.714  39.214  25.141  1.00 26.68   A
ATOM   5330  C   GLY A  49      20.783  38.447  26.055  1.00 26.11   A
ATOM   5331  O   GLY A  49      19.969  39.047  26.759  1.00 26.15   A
ATOM   5332  N   LYS A  50      20.902  37.124  26.055  1.00 25.32   A
ATOM   5333  CA  LYS A  50      20.058  36.286  26.899  1.00 24.83   A
ATOM   5334  CB  LYS A  50      18.987  35.584  26.055  1.00 25.06   A
ATOM   5335  CG  LYS A  50      18.013  36.530  25.374  1.00 25.51   A
ATOM   5336  CD  LYS A  50      17.150  37.251  26.398  1.00 25.84   A
ATOM   5337  CE  LYS A  50      16.263  38.306  25.752  1.00 26.47   A
ATOM   5338  NZ  LYS A  50      15.382  37.745  24.694  1.00 26.77   A
ATOM   5339  C   LYS A  50      20.879  35.240  27.634  1.00 24.41   A
ATOM   5340  O   LYS A  50      21.944  34.833  27.172  1.00 24.16   A
ATOM   5341  N   ILE A  51      20.383  34.825  28.794  1.00 23.98   A
ATOM   5342  CA  ILE A  51      21.045  33.800  29.586  1.00 23.81   A
ATOM   5343  CB  ILE A  51      21.654  34.373  30.889  1.00 23.59   A
ATOM   5344  CG2 ILE A  51      22.946  35.101  30.569  1.00 23.66   A
ATOM   5345  CG1 ILE A  51      20.647  35.286  31.588  1.00 23.56   A
ATOM   5346  CD1 ILE A  51      21.166  35.889  32.865  1.00 24.20   A
ATOM   5347  C   ILE A  51      20.012  32.737  29.925  1.00 23.69   A
ATOM   5348  O   ILE A  51      18.812  32.984  29.833  1.00 23.80   A
ATOM   5349  N   PRO A  52      20.461  31.545  30.341  1.00 23.80   A
ATOM   5350  CD  PRO A  52      19.562  30.408  30.617  1.00 23.80   A
ATOM   5351  CA  PRO A  52      21.862  31.148  30.517  1.00 23.83   A
ATOM   5352  CB  PRO A  52      21.744  29.860  31.315  1.00 23.75   A
ATOM   5353  CG  PRO A  52      20.522  29.241  30.696  1.00 23.82   A
ATOM   5354  C   PRO A  52      22.657  30.935  29.234  1.00 24.05   A
ATOM   5355  O   PRO A  52      22.107  30.869  28.132  1.00 23.56   A
ATOM   5356  N   ILE A  53      23.969  30.831  29.405  1.00 24.37   A
ATOM   5357  CA  ILE A  53      24.883  30.580  28.305  1.00 24.89   A
ATOM   5358  CB  ILE A  53      25.598  31.865  27.845  1.00 25.02   A
ATOM   5359  CG2 ILE A  53      24.582  32.851  27.265  1.00 25.04   A
ATOM   5360  CG1 ILE A  53      26.353  32.488  29.018  1.00 25.09   A
ATOM   5361  CD1 ILE A  53      27.139  33.725  28.651  1.00 25.71   A
ATOM   5362  C   ILE A  53      25.920  29.600  28.830  1.00 25.23   A
ATOM   5363  O   ILE A  53      26.251  29.620  30.017  1.00 25.22   A
ATOM   5423  N   HIS A  62      24.143  29.233  23.623  1.00 22.53   A
ATOM   5424  CA  HIS A  62      22.973  29.778  24.304  1.00 21.30   A
ATOM   5425  CB  HIS A  62      22.641  31.181  23.777  1.00 21.36   A
ATOM   5426  CG  HIS A  62      22.241  31.212  22.334  1.00 21.08   A
ATOM   5427  CD2 HIS A  62      21.074  31.557  21.739  1.00 20.76   A
ATOM   5428  ND1 HIS A  62      23.112  30.897  21.314  1.00 21.06   A
ATOM   5429  CE1 HIS A  62      22.502  31.050  20.152  1.00 20.77   A
ATOM   5430  NE2 HIS A  62      21.264  31.449  20.382  1.00 21.11   A
ATOM   5431  C   HIS A  62      21.754  28.875  24.145  1.00 20.50   A
ATOM   5432  O   HIS A  62      21.812  27.856  23.457  1.00 20.45   A
ATOM   5433  N   GLN A  63      20.653  29.279  24.776  1.00 19.38   A
ATOM   5434  CA  GLN A  63      19.395  28.531  24.759  1.00 18.32   A
ATOM   5435  CB  GLN A  63      19.006  28.135  23.327  1.00 18.21   A
ATOM   5436  CG  GLN A  63      18.351  29.257  22.523  1.00 17.55   A
ATOM   5437  CD  GLN A  63      17.052  29.748  23.159  1.00 17.51   A
ATOM   5438  OE1 GLN A  63      16.447  29.061  23.990  1.00 16.96   A
ATOM   5439  NE2 GLN A  63      16.614  30.932  22.760  1.00 16.64   A
ATOM   5440  C   GLN A  63      19.548  27.295  25.640  1.00 17.51   A
ATOM   5441  O   GLN A  63      20.204  26.326  25.262  1.00 17.52   A
ATOM   5442  N   SER A  64      18.922  27.343  26.810  1.00 16.62   A
ATOM   5443  CA  SER A  64      19.005  26.266  27.787  1.00 16.23   A
ATOM   5444  CB  SER A  64      18.109  26.580  28.994  1.00 15.75   A
ATOM   5445  OG  SER A  64      16.739  26.636  28.636  1.00 16.02   A
ATOM   5446  C   SER A  64      18.690  24.871  27.264  1.00 16.04   A
ATOM   5447  O   SER A  64      19.416  23.927  27.561  1.00 15.93   A
ATOM   5448  N   LEU A  65      17.623  24.736  26.484  1.00 15.93   A
ATOM   5449  CA  LEU A  65      17.243  23.426  25.969  1.00 16.08   A
ATOM   5450  CB  LEU A  65      15.781  23.445  25.509  1.00 16.21   A
ATOM   5451  CG  LEU A  65      14.757  23.960  26.532  1.00 16.82   A
ATOM   5452  CD1 LEU A  65      13.348  23.839  25.954  1.00 17.04   A
ATOM   5453  CD2 LEU A  65      14.862  23.156  27.831  1.00 16.97   A
ATOM   5454  C   LEU A  65      18.168  22.953  24.846  1.00 16.25   A
ATOM   5455  O   LEU A  65      18.403  21.753  24.693  1.00 16.15   A
ATOM   5662  N   ASP A  93       9.463  20.540  25.416  1.00 15.24   A
ATOM   5663  CA  ASP A  93       8.886  21.742  24.818  1.00 15.43   A
ATOM   5664  CB  ASP A  93       8.800  21.598  23.289  1.00 16.54   A
ATOM   5665  CG  ASP A  93      10.083  22.013  22.578  1.00 17.29   A
ATOM   5666  OD1 ASP A  93      10.162  21.833  21.338  1.00 18.80   A
ATOM   5667  OD2 ASP A  93      11.014  22.527  23.240  1.00 17.97   A
ATOM   5668  C   ASP A  93       7.496  22.053  25.388  1.00 15.31   A
ATOM   5669  O   ASP A  93       7.138  23.220  25.568  1.00 15.25   A
ATOM   5670  N   THR A  94       6.707  21.016  25.658  1.00 15.02   A
ATOM   5671  CA  THR A  94       5.371  21.207  26.224  1.00 15.27   A
ATOM   5672  CB  THR A  94       4.640  19.861  26.399  1.00 15.32   A
ATOM   5673  OG1 THR A  94       4.193  19.397  25.118  1.00 16.10   A
ATOM   5674  CG2 THR A  94       3.432  20.011  27.323  1.00 15.76   A
ATOM   5675  C   THR A  94       5.483  21.895  27.584  1.00 15.32   A
ATOM   5676  O   THR A  94       4.756  22.843  27.878  1.00 14.89   A
ATOM   5677  N   LEU A  95       6.406  21.408  28.407  1.00 15.54   A
ATOM   5678  CA  LEU A  95       6.615  21.982  29.732  1.00 16.01   A
ATOM   5679  CB  LEU A  95       7.593  21.115  30.535  1.00 16.19   A
ATOM   5680  CG  LEU A  95       7.089  19.738  30.998  1.00 16.12   A
ATOM   5681  CD1 LEU A  95       8.230  18.966  31.648  1.00 16.47   A
ATOM   5682  CD2 LEU A  95       5.934  19.903  31.975  1.00 16.46   A
ATOM   5683  C   LEU A  95       7.167  23.402  29.590  1.00 16.45   A
ATOM   5684  O   LEU A  95       6.744  24.320  30.296  1.00 16.19   A
ATOM   5685  N   ASP A  96       8.112  23.576  28.667  1.00 16.83   A
ATOM   5686  CA  ASP A  96       8.718  24.886  28.435  1.00 17.42   A
ATOM   5687  CB  ASP A  96       9.834  24.776  27.388  1.00 17.70   A
ATOM   5688  CG  ASP A  96      10.761  25.977  27.397  1.00 18.24   A
ATOM   5689  OD1 ASP A  96      11.259  26.318  28.496  1.00 19.16   A
ATOM   5690  OD2 ASP A  96      11.004  26.566  26.314  1.00 17.96   A
ATOM   5691  C   ASP A  96       7.670  25.906  27.982  1.00 17.76   A
ATOM   5692  O   ASP A  96       7.707  27.074  28.383  1.00 17.65   A
ATOM   5693  N   ASP A  97       6.741  25.463  27.140  1.00 18.16   A
ATOM   5694  CA  ASP A  97       5.672  26.328  26.642  1.00 18.58   A
ATOM   5695  CB  ASP A  97       4.759  25.559  25.681  1.00 18.77   A
ATOM   5696  CG  ASP A  97       5.388  25.333  24.313  1.00 19.31   A
ATOM   5697  OD1 ASP A  97       4.838  24.515  23.539  1.00 19.60   A
ATOM   5698  OD2 ASP A  97       6.420  25.973  24.007  1.00 19.36   A
ATOM   5699  C   ASP A  97       4.820  26.880  27.786  1.00 18.77   A
ATOM   5700  O   ASP A  97       4.480  28.063  27.799  1.00 18.43   A
ATOM   5701  N   PHE A  98       4.473  26.017  28.738  1.00 18.98   A
ATOM   5702  CA  PHE A  98       3.644  26.427  29.865  1.00 19.59   A
ATOM   5703  CB  PHE A  98       3.170  25.208  30.662  1.00 19.85   A
ATOM   5704  CG  PHE A  98       2.225  25.554  31.787  1.00 20.49   A
ATOM   5705  CD1 PHE A  98       1.002  26.164  31.520  1.00 20.75   A
ATOM   5706  CD2 PHE A  98       2.561  25.279  33.110  1.00 21.00   A
ATOM   5707  CE1 PHE A  98       0.126  26.496  32.557  1.00 21.20   A
ATOM   5708  CE2 PHE A  98       1.690  25.608  34.156  1.00 20.81   A
ATOM   5709  CZ  PHE A  98       0.473  26.216  33.876  1.00 21.25   A
ATOM   5710  C   PHE A  98       4.382  27.373  30.798  1.00 19.70   A
ATOM   5711  O   PHE A  98       3.849  28.407  31.193  1.00 19.84   A
ATOM   5712  N   MET A  99       5.610  27.010  31.148  1.00 19.93   A
ATOM   5713  CA  MET A  99       6.422  27.834  32.038  1.00 20.62   A
ATOM   5714  CB  MET A  99       7.759  27.150  32.323  1.00 20.56   A
ATOM   5715  CG  MET A  99       7.642  25.794  32.999  1.00 20.77   A
ATOM   5716  SD  MET A  99       6.765  25.897  34.599  1.00 20.94   A
ATOM   5717  CE  MET A  99       7.971  26.856  35.571  1.00 21.40   A
ATOM   5718  C   MET A  99       6.684  29.200  31.418  1.00 21.19   A
ATOM   5719  O   MET A  99       6.770  30.205  32.123  1.00 20.97   A
ATOM   5720  N   SER A 100       6.817  29.232  30.094  1.00 21.87   A
ATOM   5721  CA  SER A 100       7.088  30.480  29.391  1.00 22.86   A
ATOM   5722  CB  SER A 100       7.626  30.190  27.986  1.00 22.52   A
ATOM   5723  OG  SER A 100       8.932  29.641  28.064  1.00 23.15   A
ATOM   5724  C   SER A 100       5.874  31.400  29.310  1.00 23.42   A
ATOM   5725  O   SER A 100       5.999  32.570  28.944  1.00 23.43   A
ATOM   5726  N   CYS A 101       4.705  30.871  29.656  1.00 24.43   A
ATOM   5727  CA  CYS A 101       3.470  31.649  29.642  1.00 25.43   A
ATOM   5728  CB  CYS A 101       2.246  30.732  29.736  1.00 25.71   A
ATOM   5729  SG  CYS A 101       1.749  29.932  28.189  1.00 27.17   A
ATOM   5730  C   CYS A 101       3.427  32.631  30.806  1.00 25.95   A
ATOM   5731  O   CYS A 101       2.818  33.695  30.704  1.00 25.87   A
ATOM   5732  N   PHE A 102       4.060  32.272  31.919  1.00 26.64   A
ATOM   5733  CA  PHE A 102       4.055  33.150  33.084  1.00 27.61   A
ATOM   5734  CB  PHE A 102       4.567  32.416  34.328  1.00 27.12   A
ATOM   5735  CG  PHE A 102       3.679  31.293  34.780  1.00 26.71   A
ATOM   5736  CD1 PHE A 102       3.627  30.100  34.067  1.00 26.53   A
ATOM   5737  CD2 PHE A 102       2.904  31.422  35.930  1.00 26.49   A
ATOM   5738  CE1 PHE A 102       2.814  29.047  34.495  1.00 26.51   A
ATOM   5739  CE2 PHE A 102       2.089  30.378  36.366  1.00 26.35   A
ATOM   5740  CZ  PHE A 102       2.044  29.187  35.648  1.00 26.32   A
ATOM   5741  C   PHE A 102       4.896  34.401  32.862  1.00 28.66   A
ATOM   5742  O   PHE A 102       6.020  34.328  32.366  1.00 28.59   A
ATOM   5743  N   PRO A 103       4.353  35.572  33.228  1.00 29.73   A
ATOM   5744  CD  PRO A 103       2.973  35.797  33.697  1.00 29.81   A
ATOM   5745  CA  PRO A 103       5.059  36.846  33.070  1.00 30.81   A
ATOM   5746  CB  PRO A 103       3.927  37.865  33.132  1.00 30.54   A
ATOM   5747  CG  PRO A 103       3.012  37.251  34.137  1.00 30.22   A
ATOM   5748  C   PRO A 103       6.087  37.050  34.183  1.00 31.87   A
ATOM   5749  O   PRO A 103       5.896  37.883  35.069  1.00 31.89   A
ATOM   5750  N   TRP A 104       7.173  36.284  34.134  1.00 33.14   A
ATOM   5751  CA  TRP A 104       8.218  36.373  35.147  1.00 34.59   A
ATOM   5752  CB  TRP A 104       9.315  35.340  34.874  1.00 34.65   A
ATOM   5753  CG  TRP A 104       8.796  33.949  34.643  1.00 34.60   A
ATOM   5754  CD2 TRP A 104       8.342  33.023  35.639  1.00 34.60   A
ATOM   5755  CE2 TRP A 104       7.930  31.852  34.965  1.00 34.60   A
ATOM   5756  CE3 TRP A 104       8.243  33.068  37.038  1.00 34.59   A
ATOM   5757  CD1 TRP A 104       8.644  33.320  33.440  1.00 34.55   A
ATOM   5758  NE1 TRP A 104       8.126  32.060  33.624  1.00 34.48   A
ATOM   5759  CZ2 TRP A 104       7.427  30.736  35.641  1.00 34.52   A
ATOM   5760  CZ3 TRP A 104       7.743  31.959  37.709  1.00 34.54   A
ATOM   5761  CH2 TRP A 104       7.341  30.809  37.009  1.00 34.78   A
ATOM   5762  C   TRP A 104       8.837  37.765  35.207  1.00 35.65   A
ATOM   5763  O   TRP A 104       9.139  38.270  36.286  1.00 35.74   A
ATOM   5764  N   ALA A 105       9.024  38.379  34.044  1.00 37.02   A
ATOM   5765  CA  ALA A 105       9.612  39.712  33.960  1.00 38.45   A
ATOM   5766  CB  ALA A 105      10.630  39.762  32.826  1.00 38.40   A
ATOM   5767  C   ALA A 105       8.541  40.776  33.743  1.00 39.42   A
ATOM   5768  O   ALA A 105       8.562  41.497  32.744  1.00 39.67   A
ATOM   5769  N   GLU A 106       7.604  40.871  34.677  1.00 40.55   A
ATOM   5770  CA  GLU A 106       6.536  41.854  34.566  1.00 41.69   A
ATOM   5771  CB  GLU A 106       5.178  41.152  34.484  1.00 41.79   A
ATOM   5772  CG  GLU A 106       3.996  42.101  34.385  1.00 42.04   A
ATOM   5773  CD  GLU A 106       4.119  43.062  33.219  1.00 42.17   A
ATOM   5774  OE1 GLU A 106       4.135  42.600  32.059  1.00 42.24   A
ATOM   5775  OE2 GLU A 106       4.207  44.282  33.461  1.00 42.30   A
ATOM   5776  C   GLU A 106       6.549  42.817  35.745  1.00 42.38   A
ATOM   5777  O   GLU A 106       6.252  42.433  36.877  1.00 42.50   A
ATOM   5778  N   LYS A 107       6.902  44.071  35.471  1.00 43.32   A
ATOM   5779  CA  LYS A 107       6.949  45.105  36.498  1.00 44.17   A
ATOM   5780  CB  LYS A 107       7.501  46.408  35.916  1.00 44.38   A
ATOM   5781  CG  LYS A 107       9.001  46.575  36.067  1.00 44.83   A
ATOM   5782  CD  LYS A 107       9.773  45.472  35.376  1.00 45.12   A
ATOM   5783  CE  LYS A 107      11.261  45.611  35.654  1.00 45.28   A
ATOM   5784  NZ  LYS A 107      11.534  45.551  37.119  1.00 45.38   A
ATOM   5785  C   LYS A 107       5.573  45.364  37.100  1.00 44.67   A
ATOM   5786  O   LYS A 107       5.431  45.477  38.318  1.00 44.70   A
ATOM   5787  N   LYS A 108       4.563  45.460  36.240  1.00 45.16   A
ATOM   5788  CA  LYS A 108       3.197  45.701  36.688  1.00 45.71   A
ATOM   5789  CB  LYS A 108       2.268  45.869  35.483  1.00 45.85   A
ATOM   5790  CG  LYS A 108       2.686  46.978  34.531  1.00 46.17   A
ATOM   5791  CD  LYS A 108       1.639  47.224  33.455  1.00 46.42   A
ATOM   5792  CE  LYS A 108       1.458  46.017  32.549  1.00 46.68   A
ATOM   5793  NZ  LYS A 108       0.371  46.242  31.554  1.00 46.81   A
ATOM   5794  C   LYS A 108       2.731  44.533  37.551  1.00 46.00   A
ATOM   5795  O   LYS A 108       2.296  43.501  37.038  1.00 45.89   A
ATOM   5796  N   GLN A 109       2.825  44.704  38.865  1.00 46.38   A
ATOM   5797  CA  GLN A 109       2.438  43.660  39.809  1.00 46.76   A
ATOM   5798  CB  GLN A 109       2.710  44.125  41.242  1.00 47.02   A
ATOM   5799  CG  GLN A 109       4.150  44.545  41.500  1.00 47.38   A
ATOM   5800  CD  GLN A 109       5.148  43.428  41.243  1.00 47.66   A
ATOM   5801  OE1 GLN A 109       5.062  42.353  41.842  1.00 47.81   A
ATOM   5802  NE2 GLN A 109       6.105  43.679  40.350  1.00 47.68   A
ATOM   5803  C   GLN A 109       0.977  43.252  39.674  1.00 46.90   A
ATOM   5804  O   GLN A 109       0.627  42.091  39.890  1.00 46.97   A
ATOM   5805  N   ASP A 110       0.127  44.209  39.315  1.00 47.00   A
ATOM   5806  CA  ASP A 110      -1.301  43.948  39.159  1.00 47.06   A
ATOM   5807  CB  ASP A 110      -2.046  45.251  38.853  1.00 47.31   A
ATOM   5808  CG  ASP A 110      -1.945  46.256  39.982  1.00 47.59   A
ATOM   5809  OD1 ASP A 110      -2.246  45.881  41.136  1.00 47.70   A
ATOM   5810  OD2 ASP A 110      -1.571  47.419  39.717  1.00 47.82   A
ATOM   5811  C   ASP A 110      -1.584  42.926  38.063  1.00 46.90   A
ATOM   5812  O   ASP A 110      -2.203  41.891  38.314  1.00 46.87   A
ATOM   5813  N   VAL A 111      -1.127  43.220  36.850  1.00 46.72   A
ATOM   5814  CA  VAL A 111      -1.338  42.326  35.719  1.00 46.57   A
ATOM   5815  CB  VAL A 111      -0.918  42.999  34.391  1.00 46.71   A
ATOM   5816  CG1 VAL A 111       0.588  43.192  34.357  1.00 46.96   A
ATOM   5817  CG2 VAL A 111      -1.378  42.160  33.213  1.00 46.81   A
ATOM   5818  C   VAL A 111      -0.550  41.029  35.894  1.00 46.33   A
ATOM   5819  O   VAL A 111      -0.967  39.970  35.426  1.00 46.33   A
ATOM   5820  N   LYS A 112       0.588  41.117  36.573  1.00 45.98   A
ATOM   5821  CA  LYS A 112       1.427  39.949  36.810  1.00 45.58   A
ATOM   5822  CB  LYS A 112       2.772  40.383  37.397  1.00 45.70   A
ATOM   5823  CG  LYS A 112       3.753  39.245  37.630  1.00 45.79   A
ATOM   5824  CD  LYS A 112       5.070  39.765  38.187  1.00 45.95   A
ATOM   5825  CE  LYS A 112       6.087  38.646  38.340  1.00 45.99   A
ATOM   5826  NZ  LYS A 112       5.582  37.571  39.237  1.00 46.23   A
ATOM   5827  C   LYS A 112       0.732  38.985  37.768  1.00 45.31   A
ATOM   5828  O   LYS A 112       0.597  37.793  37.481  1.00 45.18   A
ATOM   5829  N   GLU A 113       0.290  39.515  38.904  1.00 44.80   A
ATOM   5830  CA  GLU A 113      -0.390  38.718  39.920  1.00 44.37   A
ATOM   5831  CB  GLU A 113      -0.817  39.615  41.089  1.00 44.56   A
ATOM   5832  CG  GLU A 113      -1.246  38.872  42.346  1.00 44.72   A
ATOM   5833  CD  GLU A 113      -0.069  38.326  43.135  1.00 44.84   A
ATOM   5834  OE1 GLU A 113       0.653  37.451  42.611  1.00 44.74   A
ATOM   5835  OE2 GLU A 113       0.138  38.780  44.281  1.00 44.95   A
ATOM   5836  C   GLU A 113      -1.620  38.044  39.316  1.00 43.91   A
ATOM   5837  O   GLU A 113      -1.907  36.878  39.594  1.00 43.88   A
ATOM   5838  N   GLN A 114      -2.343  38.789  38.486  1.00 43.23   A
ATOM   5839  CA  GLN A 114      -3.545  38.276  37.843  1.00 42.55   A
ATOM   5840  CB  GLN A 114      -4.243  39.392  37.063  1.00 43.01   A
ATOM   5841  CG  GLN A 114      -5.502  38.952  36.330  1.00 43.48   A
ATOM   5842  CD  GLN A 114      -6.660  38.643  37.266  1.00 43.87   A
ATOM   5843  OE1 GLN A 114      -7.716  38.182  36.831  1.00 44.27   A
ATOM   5844  NE2 GLN A 114      -6.469  38.902  38.556  1.00 44.00   A
ATOM   5845  C   GLN A 114      -3.241  37.115  36.902  1.00 41.82   A
ATOM   5846  O   GLN A 114      -3.862  36.058  36.993  1.00 41.68   A
ATOM   5847  N   MET A 115      -2.287  37.318  35.999  1.00 40.95   A
ATOM   5848  CA  MET A 115      -1.914  36.286  35.039  1.00 40.08   A
ATOM   5849  CB  MET A 115      -0.823  36.806  34.096  1.00 40.62   A
ATOM   5850  CG  MET A 115      -1.283  37.947  33.197  1.00 41.32   A
ATOM   5851  SD  MET A 115      -0.084  38.396  31.912  1.00 42.25   A
ATOM   5852  CE  MET A 115       0.892  39.641  32.771  1.00 42.06   A
ATOM   5853  C   MET A 115      -1.451  34.995  35.711  1.00 39.18   A
ATOM   5854  O   MET A 115      -1.750  33.899  35.233  1.00 38.94   A
ATOM   5855  N   PHE A 116      -0.723  35.120  36.817  1.00 38.04   A
ATOM   5856  CA  PHE A 116      -0.246  33.943  37.535  1.00 37.08   A
ATOM   5857  CB  PHE A 116       0.632  34.347  38.725  1.00 36.65   A
ATOM   5858  CG  PHE A 116       2.104  34.250  38.453  1.00 36.16   A
ATOM   5859  CD1 PHE A 116       2.707  35.072  37.509  1.00 36.15   A
ATOM   5860  CD2 PHE A 116       2.887  33.323  39.130  1.00 36.09   A
ATOM   5861  CE1 PHE A 116       4.070  34.970  37.241  1.00 36.00   A
ATOM   5862  CE2 PHE A 116       4.250  33.213  38.870  1.00 36.03   A
ATOM   5863  CZ  PHE A 116       4.841  34.038  37.923  1.00 36.03   A
ATOM   5864  C   PHE A 116      -1.406  33.087  38.033  1.00 36.66   A
ATOM   5865  O   PHE A 116      -1.454  31.882  37.782  1.00 36.40   A
ATOM   6152  N   TYR A 152      13.399  17.626  33.588  1.00 17.13   A
ATOM   6153  CA  TYR A 152      12.704  18.883  33.352  1.00 16.94   A
ATOM   6154  CB  TYR A 152      12.549  19.144  31.854  1.00 17.23   A
ATOM   6155  CG  TYR A 152      12.463  20.619  31.522  1.00 17.59   A
ATOM   6156  CD1 TYR A 152      13.414  21.519  32.010  1.00 17.83   A
ATOM   6157  CE1 TYR A 152      13.368  22.871  31.673  1.00 18.02   A
ATOM   6158  CD2 TYR A 152      11.459  21.111  30.693  1.00 17.66   A
ATOM   6159  CE2 TYR A 152      11.407  22.460  30.349  1.00 17.94   A
ATOM   6160  CZ  TYR A 152      12.363  23.331  30.837  1.00 18.06   A
ATOM   6161  OH  TYR A 152      12.339  24.652  30.461  1.00 18.13   A
ATOM   6162  C   TYR A 152      11.342  18.931  34.031  1.00 17.03   A
ATOM   6163  O   TYR A 152      10.893  19.996  34.459  1.00 16.79   A
ATOM   6164  N   TRP A 153      10.684  17.780  34.127  1.00 16.68   A
ATOM   6165  CA  TRP A 153       9.391  17.714  34.782  1.00 16.70   A
ATOM   6166  CB  TRP A 153       8.792  16.311  34.662  1.00 17.07   A
ATOM   6167  CG  TRP A 153       7.822  16.001  35.761  1.00 18.05   A
ATOM   6168  CD2 TRP A 153       6.615  16.708  36.066  1.00 18.42   A
ATOM   6169  CE2 TRP A 153       6.049  16.095  37.206  1.00 18.78   A
ATOM   6170  CE3 TRP A 153       5.956  17.800  35.488  1.00 18.93   A
ATOM   6171  CD1 TRP A 153       7.936  15.014  36.699  1.00 18.52   A
ATOM   6172  NE1 TRP A 153       6.874  15.065  37.570  1.00 18.65   A
ATOM   6173  CZ2 TRP A 153       4.852  16.540  37.781  1.00 18.98   A
ATOM   6174  CZ3 TRP A 153       4.761  18.245  36.063  1.00 19.09   A
ATOM   6175  CH2 TRP A 153       4.225  17.613  37.198  1.00 18.95   A
ATOM   6176  C   TRP A 153       9.578  18.055  36.253  1.00 16.19   A
ATOM   6177  O   TRP A 153       8.844  18.868  36.804  1.00 16.11   A
ATOM   6178  N   GLU A 154      10.571  17.429  36.879  1.00 15.99   A
ATOM   6179  CA  GLU A 154      10.850  17.652  38.301  1.00 15.99   A
ATOM   6180  CB  GLU A 154      11.985  16.725  38.759  1.00 16.41   A
ATOM   6181  CG  GLU A 154      12.159  16.644  40.282  1.00 17.45   A
ATOM   6182  CD  GLU A 154      12.954  17.795  40.864  1.00 17.87   A
ATOM   6183  OE1 GLU A 154      12.895  18.000  42.103  1.00 18.47   A
ATOM   6184  OE2 GLU A 154      13.648  18.489  40.093  1.00 18.04   A
ATOM   6185  C   GLU A 154      11.208  19.112  38.564  1.00 15.58   A
ATOM   6186  O   GLU A 154      10.793  19.697  39.568  1.00 15.32   A
ATOM   6187  N   ILE A 155      11.973  19.694  37.647  1.00 14.97   A
ATOM   6188  CA  ILE A 155      12.391  21.088  37.747  1.00 14.96   A
ATOM   6189  CB  ILE A 155      13.460  21.401  36.665  1.00 14.64   A
ATOM   6190  CG2 ILE A 155      13.621  22.906  36.479  1.00 14.51   A
ATOM   6191  CG1 ILE A 155      14.779  20.722  37.054  1.00 14.76   A
ATOM   6192  CD1 ILE A 155      15.871  20.787  35.989  1.00 14.27   A
ATOM   6193  C   ILE A 155      11.207  22.044  37.609  1.00 15.18   A
ATOM   6194  O   ILE A 155      11.032  22.952  38.425  1.00 15.10   A
ATOM   6195  N   CYS A 156      10.394  21.840  36.574  1.00 15.13   A
ATOM   6196  CA  CYS A 156       9.225  22.688  36.351  1.00 15.67   A
ATOM   6197  CB  CYS A 156       8.573  22.365  34.998  1.00 15.61   A
ATOM   6198  SG  CYS A 156       9.519  22.879  33.537  1.00 16.74   A
ATOM   6199  C   CYS A 156       8.175  22.557  37.462  1.00 15.81   A
ATOM   6200  O   CYS A 156       7.612  23.558  37.904  1.00 15.91   A
ATOM   6201  N   SER A 157       7.904  21.331  37.905  1.00 15.84   A
ATOM   6202  CA  SER A 157       6.908  21.113  38.954  1.00 16.04   A
ATOM   6203  CB  SER A 157       6.614  19.614  39.117  1.00 15.82   A
ATOM   6204  OG  SER A 157       7.799  18.879  39.353  1.00 15.23   A
ATOM   6205  C   SER A 157       7.375  21.713  40.279  1.00 16.34   A
ATOM   6206  O   SER A 157       6.566  22.205  41.075  1.00 16.25   A
ATOM   6207  N   THR A 158       8.681  21.678  40.519  1.00 16.57   A
ATOM   6208  CA  THR A 158       9.218  22.252  41.750  1.00 17.18   A
ATOM   6209  CB  THR A 158      10.756  22.149  41.796  1.00 17.24   A
ATOM   6210  OG1 THR A 158      11.129  20.790  42.058  1.00 17.94   A
ATOM   6211  CG2 THR A 158      11.324  23.039  42.895  1.00 17.40   A
ATOM   6212  C   THR A 158       8.807  23.721  41.862  1.00 17.28   A
ATOM   6213  O   THR A 158       8.266  24.154  42.884  1.00 17.37   A
ATOM   6214  N   THR A 159       9.056  24.484  40.805  1.00 17.51   A
ATOM   6215  CA  THR A 159       8.705  25.900  40.790  1.00 17.92   A
ATOM   6216  CB  THR A 159       9.303  26.594  39.543  1.00 17.65   A
ATOM   6217  OG1 THR A 159      10.730  26.596  39.653  1.00 17.96   A
ATOM   6218  CG2 THR A 159       8.812  28.033  39.421  1.00 18.36   A
ATOM   6219  C   THR A 159       7.193  26.107  40.836  1.00 17.91   A
ATOM   6220  O   THR A 159       6.702  26.981  41.554  1.00 18.18   A
ATOM   6221  N   LEU A 160       6.446  25.307  40.084  1.00 18.04   A
ATOM   6222  CA  LEU A 160       4.995  25.448  40.098  1.00 18.10   A
ATOM   6223  CB  LEU A 160       4.350  24.485  39.102  1.00 18.30   A
ATOM   6224  CG  LEU A 160       4.599  24.829  37.627  1.00 18.44   A
ATOM   6225  CD1 LEU A 160       3.998  23.744  36.741  1.00 18.61   A
ATOM   6226  CD2 LEU A 160       3.995  26.185  37.298  1.00 18.31   A
ATOM   6227  C   LEU A 160       4.445  25.190  41.500  1.00 18.29   A
ATOM   6228  O   LEU A 160       3.524  25.874  41.939  1.00 18.04   A
ATOM   6229  N   LEU A 161       5.014  24.209  42.199  1.00 18.58   A
ATOM   6230  CA  LEU A 161       4.562  23.867  43.554  1.00 18.65   A
ATOM   6231  CB  LEU A 161       5.288  22.617  44.061  1.00 18.76   A
ATOM   6232  CG  LEU A 161       4.830  21.269  43.494  1.00 18.94   A
ATOM   6233  CD1 LEU A 161       5.881  20.206  43.761  1.00 18.87   A
ATOM   6234  CD2 LEU A 161       3.494  20.881  44.115  1.00 18.81   A
ATOM   6235  C   LEU A 161       4.769  25.009  44.545  1.00 18.70   A
ATOM   6236  O   LEU A 161       4.100  25.078  45.580  1.00 18.70   A
ATOM   6237  N   VAL A 162       5.713  25.892  44.242  1.00 18.91   A
ATOM   6238  CA  VAL A 162       5.982  27.038  45.111  1.00 19.05   A
ATOM   6239  CB  VAL A 162       7.268  27.775  44.679  1.00 18.98   A
ATOM   6240  CG1 VAL A 162       7.376  29.108  45.403  1.00 19.21   A
ATOM   6241  CG2 VAL A 162       8.485  26.911  44.990  1.00 18.86   A
ATOM   6242  C   VAL A 162       4.807  28.012  45.079  1.00 19.45   A
ATOM   6243  O   VAL A 162       4.496  28.669  46.076  1.00 19.46   A
ATOM   6244  N   PHE A 163       4.144  28.096  43.932  1.00 19.57   A
ATOM   6245  CA  PHE A 163       3.013  28.998  43.797  1.00 20.03   A
ATOM   6246  CB  PHE A 163       3.087  29.734  42.458  1.00 20.31   A
ATOM   6247  CG  PHE A 163       4.337  30.550  42.291  1.00 20.50   A
ATOM   6248  CD1 PHE A 163       5.466  29.999  41.696  1.00 20.62   A
ATOM   6249  CD2 PHE A 163       4.403  31.856  42.771  1.00 20.68   A
ATOM   6250  CE1 PHE A 163       6.644  30.732  41.581  1.00 20.55   A
ATOM   6251  CE2 PHE A 163       5.578  32.598  42.661  1.00 20.66   A
ATOM   6252  CZ  PHE A 163       6.701  32.032  42.064  1.00 20.63   A
ATOM   6253  C   PHE A 163       1.669  28.302  43.933  1.00 20.28   A
ATOM   6254  O   PHE A 163       0.664  28.948  44.218  1.00 20.48   A
ATOM   6528  N   THR A 197      16.338  29.399  46.423  1.00 26.20   A
ATOM   6529  CA  THR A 197      15.751  30.609  45.863  1.00 25.74   A
ATOM   6530  CB  THR A 197      16.490  31.036  44.577  1.00 25.61   A
ATOM   6531  OG1 THR A 197      16.472  29.955  43.637  1.00 25.05   A
ATOM   6532  CG2 THR A 197      17.930  31.404  44.885  1.00 25.60   A
ATOM   6533  C   THR A 197      14.275  30.422  45.534  1.00 25.48   A
ATOM   6534  O   THR A 197      13.779  29.297  45.478  1.00 25.55   A
ATOM   6535  N   LYS A 198      13.579  31.533  45.321  1.00 25.39   A
ATOM   6536  CA  LYS A 198      12.158  31.503  44.987  1.00 25.33   A
ATOM   6537  CB  LYS A 198      11.588  32.923  44.977  1.00 25.43   A
ATOM   6538  CG  LYS A 198      10.103  32.992  44.646  1.00 25.92   A
ATOM   6539  CD  LYS A 198       9.614  34.427  44.597  1.00 26.17   A
ATOM   6540  CE  LYS A 198       8.186  34.502  44.089  1.00 26.49   A
ATOM   6541  NZ  LYS A 198       7.712  35.915  43.956  1.00 26.69   A
ATOM   6542  C   LYS A 198      11.943  30.855  43.621  1.00 25.18   A
ATOM   6543  O   LYS A 198      11.110  29.962  43.473  1.00 24.95   A
ATOM   6544  N   LEU A 199      12.699  31.313  42.628  1.00 25.13   A
ATOM   6545  CA  LEU A 199      12.595  30.781  41.270  1.00 25.12   A
ATOM   6546  CB  LEU A 199      12.408  31.930  40.275  1.00 25.36   A
ATOM   6547  CG  LEU A 199      10.969  32.324  39.926  1.00 25.73   A
ATOM   6548  CD1 LEU A 199      10.105  32.362  41.171  1.00 25.91   A
ATOM   6549  CD2 LEU A 199      10.981  33.665  39.212  1.00 25.98   A
ATOM   6550  C   LEU A 199      13.812  29.952  40.870  1.00 25.09   A
ATOM   6551  O   LEU A 199      14.823  29.989  41.603  1.00 24.71   A
ATOM   6552  OXT LEU A 199      13.742  29.281  39.817  1.00 24.81   A
ATOM   6613  N1  GSH H 200      14.696  30.844  25.962  1.00 23.65   H
ATOM   6614  CA1 GSH H 200      16.039  31.001  26.524  1.00 23.55   H
ATOM   6615  C1  GSH H 200      16.542  29.694  27.171  1.00 23.17   H
ATOM   6616  O11 GSH H 200      15.739  28.768  27.396  1.00 22.46   H
ATOM   6617  O12 GSH H 200      17.802  29.693  27.562  1.00 22.86   H
ATOM   6618  CB1 GSH H 200      15.985  32.066  27.622  1.00 23.81   H
ATOM   6619  CG1 GSH H 200      15.892  33.498  27.090  1.00 24.34   H
ATOM   6620  CD1 GSH H 200      15.490  34.394  28.280  1.00 23.98   H
ATOM   6621  OE1 GSH H 200      14.442  35.015  28.215  1.00 24.41   H
ATOM   6622  N2  GSH H 200      16.359  34.466  29.315  1.00 24.28   H
ATOM   6623  CA2 GSH H 200      16.110  35.405  30.441  1.00 24.46   H
ATOM   6624  C2  GSH H 200      16.959  36.558  30.276  1.00 24.90   H
ATOM   6625  O2  GSH H 200      18.145  36.447  29.952  1.00 24.83   H
ATOM   6626  CB2 GSH H 200      16.495  34.762  31.809  1.00 24.14   H
ATOM   6627  SG2 GSH H 200      15.212  33.684  32.529  1.00 23.62   H
ATOM   6628  N3  GSH H 200      16.418  37.764  30.605  1.00 25.69   H
ATOM   6629  CA3 GSH H 200      17.234  39.007  30.688  1.00 26.56   H
ATOM   6630  C3  GSH H 200      16.858  39.970  29.572  1.00 27.05   H
ATOM   6631  O31 GSH H 200      17.544  41.013  29.478  1.00 27.21   H
ATOM   6632  O32 GSH H 200      15.926  39.647  28.800  1.00 27.38   H
ATOM   6708  C1  U44 X 201      12.551  37.412  34.770  1.00 51.36   X
ATOM   6709  C2  U44 X 201      12.942  38.049  36.088  1.00 51.45   X
ATOM   6710  C3  U44 X 201      13.074  36.818  37.021  1.00 51.46   X
ATOM   6711  C4  U44 X 201      13.773  35.785  36.065  1.00 51.25   X
ATOM   6712  C5  U44 X 201      13.862  36.633  34.758  1.00 51.32   X
ATOM   6713  C7  U44 X 201      14.906  37.744  34.890  1.00 51.38   X
ATOM   6714  O6  U44 X 201      14.219  38.627  35.787  1.00 51.43   X
ATOM   6715  C14 U44 X 201      13.023  34.496  35.785  1.00 50.82   X
ATOM   6716  C16 U44 X 201      13.358  33.226  36.116  1.00 50.17   X
ATOM   6717  C18 U44 X 201      12.548  31.983  35.806  1.00 49.75   X
ATOM   6718  C20 U44 X 201      12.422  31.711  34.291  1.00 49.34   X
ATOM   6719  C21 U44 X 201      11.452  30.558  33.949  1.00 48.88   X
ATOM   6720  C24 U44 X 201      12.111  29.171  34.031  1.00 48.50   X
ATOM   6721  C27 U44 X 201      11.176  28.042  33.569  1.00 48.26   X
ATOM   6722  C30 U44 X 201      11.730  26.655  33.911  1.00 47.93   X
ATOM   6723  O36 U44 X 201      11.255  32.146  36.348  1.00 49.97   X
ATOM   6724  C39 U44 X 201      13.871  37.120  38.326  1.00 51.81   X
ATOM   6725  C41 U44 X 201      13.309  36.423  39.545  1.00 52.19   X
ATOM   6726  C44 U44 X 201      12.673  36.957  40.612  1.00 52.52   X
ATOM   6727  C46 U44 X 201      12.354  38.413  40.860  1.00 52.74   X
ATOM   6728  C48 U44 X 201      11.089  38.600  41.702  1.00 52.91   X
ATOM   6729  C51 U44 X 201      10.411  39.953  41.420  1.00 53.03   X
ATOM   6730  C54 U44 X 201       8.878  39.832  41.396  1.00 53.12   X
ATOM   6731  O57 U44 X 201       8.298  41.019  41.144  1.00 53.23   X
ATOM   6732  O58 U44 X 201       8.266  38.823  41.572  1.00 53.07   X
ATOM   6734 CA+2 CA2 M 901       9.824  26.883  22.168  1.00 37.63   M
ATOM   6747  OH2 WAT S  53      10.720  26.574  23.734  1.00 13.42   S
ATOM   6748  OH2 WAT S  54       8.700  27.621  24.867  1.00 30.29   S
ATOM   6749  OH2 WAT S  55      11.193  25.711  20.926  1.00 38.39   S
ATOM   6750  OH2 WAT S  56       8.649  29.181  22.554  1.00 40.32   S
ATOM   6751  OH2 WAT S  57       8.686  24.965  22.598  1.00 24.31   S
ATOM   6753  OH2 WAT S  59      12.609  27.997  22.910  1.00 26.01   S
ATOM   6754  OH2 WAT S  60      16.147  26.525  24.446  1.00 13.92   S
ATOM   6805  OH2 WAT S 119      15.889  24.704  33.708  1.00 12.20   S
ATOM   6817  OH2 WAT S 131      21.842  34.840  24.519  1.00 17.76   S
ATOM   6831  OH2 WAT S 145      13.761  25.970  37.415  1.00 14.51   S
ATOM   6838  OH2 WAT S 152      19.797  31.378  26.404  1.00 15.01   S
ATOM   6840  OH2 WAT S 154      17.705  34.244  22.558  1.00 19.55   S
ATOM   6862  OH2 WAT S 176      15.045  34.087  23.449  1.00 22.78   S
ATOM   6865  OH2 WAT S 179      24.231  27.246  21.186  1.00 17.23   S
ATOM   6868  OH2 WAT S 182      15.019  25.681  30.985  1.00 20.42   S
ATOM   6880  OH2 WAT S 194      18.957  28.395  43.148  1.00 25.25   S
ATOM   6884  OH2 WAT S 198      29.524  31.402  30.656  1.00 21.38   S
ATOM   6891  OH2 WAT S 205      12.982  24.357  39.397  1.00 27.06   S
ATOM   6911  OH2 WAT S 225      20.243  26.057  41.600  1.00 17.45   S
ATOM   6915  OH2 WAT S 229      13.072  28.340  28.775  1.00 23.00   S
ATOM   6920  OH2 WAT S 234      14.180  35.687  21.027  1.00 19.10   S
ATOM   6925  OH2 WAT S 239      16.432  26.840  45.110  1.00 20.16   S
ATOM   6963  OH2 WAT S 277       9.688  38.330  46.556  1.00 22.33   S
ATOM   6971  OH2 WAT S 285      14.267  37.710  28.281  1.00 27.08   S
ATOM   6979  OH2 WAT S 293      14.265  21.922  40.759  1.00 26.98   S
ATOM   7003  OH2 WAT S 318      14.285  33.826  42.961  1.00 21.76   S
ATOM   7004  OH2 WAT S 319      18.057  40.943  23.782  1.00 35.39   S
ATOM   7031  OH2 WAT S 349      17.934  35.785  45.678  1.00 28.45   S
ATOM   7060  OH2 WAT S 383      19.852  33.145  23.977  1.00 20.17   S
ATOM   7071  OH2 WAT S 394      11.887  37.040  22.324  1.00 21.27   S
ATOM   7083  OH2 WAT S 407      13.826  35.564  25.333  1.00 32.89   S
ATOM   7091  OH2 WAT S 415      12.313  24.839  23.220  1.00 28.21   S
ATOM   7128  OH2 WAT S 454       4.663  29.761  25.692  1.00 33.93   S
ATOM   7130  OH2 WAT S 456      21.062  36.900  40.187  1.00 38.49   S
ATOM   7141  OH2 WAT S 467      16.347  39.603  43.840  1.00 38.49   S
ATOM   7172  OH2 WAT S 501      16.867  34.824  43.591  1.00 33.65   S
ATOM   7178  OH2 WAT S 508      13.919  42.210  21.359  1.00 42.62   S
ATOM   7203  OH2 WAT S 535      24.768  29.671  36.812  1.00 21.16   S
ATOM   7278  OH2 WAT S 624       9.448  41.034  37.745  1.00 45.08   S
ATOM   7311  OH2 WAT S 661      10.417  43.064  40.521  1.00 48.24   S
ATOM   7338  OH2 WAT S 690       4.520  39.297  24.898  1.00 35.89   S
ATOM   7357  OH2 WAT S 710      11.398  29.430  37.336  1.00 55.44   S
ATOM   7372  OH2 WAT S 725      29.681  36.478  31.530  1.00 46.34   S
ATOM   7377  OH2 WAT S 730      22.836  45.124  25.173  1.00 37.85   S
ATOM   7421  OH2 WAT S 777       9.127  46.643  25.394  1.00 40.66   S
ATOM   7479  OH2 WAT S 842      17.602  38.997  20.277  1.00 32.58   S
ATOM   7534  OH2 WAT S 900      16.041  43.445  43.323  1.00 38.46   S
ATOM   7540  OH2 WAT S 906      21.141  36.590  45.196  1.00 37.28   S
ATOM   7541  OH2 WAT S 907      25.332  34.472  44.401  1.00 47.03   S
ATOM   7551  OH2 WAT S 917      16.854  44.879  23.884  1.00 42.35   S
ATOM   7554  OH2 WAT S 920       8.757  33.269  28.017  1.00 43.49   S
ATOM   7647  OH2 WAT T  22      14.573  42.133  41.410  1.00 38.47   T
ATOM   7652  OH2 WAT T  27      19.585  45.803  29.005  1.00 44.65   T
ATOM   7655  OH2 WAT T  30      17.572  36.979  22.241  1.00 37.46   T
ATOM   7658  OH2 WAT T  35       6.940  39.912  44.003  1.00 34.76   T
【００５２】
【表６】
ヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び９，１１−ジデオキシ−９α，１１α−エポキシメタノプロスタグランジンＦ２α（Ｕ４４）との複合体の３次元構造座標
ATOM   4966  N   TYR A   8   -24.963   2.816  34.571  1.00 17.22  A  N
ATOM   4967  CA  TYR A   8   -23.542   2.548  34.744  1.00 17.23  A  C
ATOM   4968  CB  TYR A   8   -22.782   3.882  34.816  1.00 18.03  A  C
ATOM   4969  CG  TYR A   8   -21.275   3.759  34.770  1.00 16.45  A  C
ATOM   4970  CD1 TYR A   8   -20.632   3.243  33.642  1.00 15.64  A  C
ATOM   4971  CE1 TYR A   8   -19.248   3.117  33.595  1.00 15.32  A  C
ATOM   4972  CD2 TYR A   8   -20.491   4.152  35.854  1.00 15.73  A  C
ATOM   4973  CE2 TYR A   8   -19.101   4.032  35.821  1.00 16.61  A  C
ATOM   4974  CZ  TYR A   8   -18.486   3.511  34.688  1.00 15.90  A  C
ATOM   4975  OH  TYR A   8   -17.116   3.369  34.652  1.00 14.22  A  O
ATOM   4976  C   TYR A   8   -23.334   1.757  36.033  1.00 18.22  A  C
ATOM   4977  O   TYR A   8   -24.286   1.500  36.765  1.00 18.88  A  O
ATOM   4978  N   PHE A   9   -22.090   1.365  36.297  1.00 19.45  A  N
ATOM   4979  CA  PHE A   9   -21.755   0.631  37.511  1.00 18.46  A  C
ATOM   4980  CB  PHE A   9   -20.326   0.086  37.442  1.00 20.61  A  C
ATOM   4981  CG  PHE A   9   -20.127  -0.989  36.416  1.00 21.63  A  C
ATOM   4982  CD1 PHE A   9   -19.215  -0.817  35.380  1.00 23.34  A  C
ATOM   4983  CD2 PHE A   9   -20.830  -2.184  36.497  1.00 23.29  A  C
ATOM   4984  CE1 PHE A   9   -19.003  -1.824  34.439  1.00 23.36  A  C
ATOM   4985  CE2 PHE A   9   -20.627  -3.197  35.564  1.00 23.79  A  C
ATOM   4986  CZ  PHE A   9   -19.710  -3.016  34.531  1.00 24.43  A  C
ATOM   4987  C   PHE A   9   -21.844   1.610  38.669  1.00 19.26  A  C
ATOM   4988  O   PHE A   9   -22.025   2.812  38.457  1.00 18.28  A  O
ATOM   4989  N   ASN A  10   -21.720   1.102  39.892  1.00 19.26  A  N
ATOM   4990  CA  ASN A  10   -21.768   1.967  41.062  1.00 20.39  A  C
ATOM   4991  CB  ASN A  10   -22.307   1.229  42.289  1.00 19.56  A  C
ATOM   4992  CG  ASN A  10   -22.172   2.053  43.558  1.00 20.32  A  C
ATOM   4993  OD1 ASN A  10   -22.514   3.239  43.580  1.00 20.34  A  O
ATOM   4994  ND2 ASN A  10   -21.675   1.432  44.618  1.00 19.12  A  N
ATOM   4995  C   ASN A  10   -20.382   2.503  41.374  1.00 20.96  A  C
ATOM   4996  O   ASN A  10   -19.672   1.971  42.228  1.00 20.75  A  O
ATOM   4997  N   MET A  11   -19.998   3.547  40.651  1.00 21.28  A  N
ATOM   4998  CA  MET A  11   -18.712   4.202  40.837  1.00 21.14  A  C
ATOM   4999  CB  MET A  11   -17.558   3.255  40.479  1.00 24.46  A  C
ATOM   5000  CG  MET A  11   -17.593   2.644  39.097  1.00 28.37  A  C
ATOM   5001  SD  MET A  11   -16.405   1.269  38.962  1.00 31.57  A  S
ATOM   5002  CE  MET A  11   -17.463  -0.102  39.381  1.00 33.95  A  C
ATOM   5003  C   MET A  11   -18.690   5.449  39.971  1.00 17.84  A  C
ATOM   5004  O   MET A  11   -19.542   5.614  39.102  1.00 17.49  A  O
ATOM   5005  N   ARG A  12   -17.747   6.346  40.230  1.00 15.79  A  N
ATOM   5006  CA  ARG A  12   -17.652   7.567  39.440  1.00 14.18  A  C
ATOM   5007  CB  ARG A  12   -16.607   8.512  40.040  1.00 13.02  A  C
ATOM   5008  CG  ARG A  12   -16.888   8.917  41.491  1.00 15.40  A  C
ATOM   5009  CD  ARG A  12   -15.857   9.928  41.986  1.00 14.27  A  C
ATOM   5010  NE  ARG A  12   -14.488   9.425  41.848  1.00 15.20  A  N
ATOM   5011  CZ  ARG A  12   -13.945   8.494  42.627  1.00 14.91  A  C
ATOM   5012  NH1 ARG A  12   -14.649   7.957  43.613  1.00 15.94  A  N
ATOM   5013  NH2 ARG A  12   -12.700   8.094  42.416  1.00 14.17  A  N
ATOM   5014  C   ARG A  12   -17.258   7.170  38.020  1.00 14.06  A  C
ATOM   5015  O   ARG A  12   -18.014   7.373  37.076  1.00 12.72  A  O
ATOM   5016  N   GLY A  13   -16.067   6.598  37.889  1.00 13.50  A  N
ATOM   5017  CA  GLY A  13   -15.581   6.151  36.598  1.00 13.43  A  C
ATOM   5018  C   GLY A  13   -15.880   7.031  35.397  1.00 11.86  A  C
ATOM   5019  O   GLY A  13   -15.654   8.240  35.420  1.00 10.45  A  O
ATOM   5020  N   ARG A  14   -16.398   6.406  34.343  1.00 11.37  A  N
ATOM   5021  CA  ARG A  14   -16.708   7.100  33.096  1.00 12.46  A  C
ATOM   5022  CB  ARG A  14   -16.606   6.111  31.928  1.00 11.33  A  C
ATOM   5023  CG  ARG A  14   -15.177   5.691  31.628  1.00 13.46  A  C
ATOM   5024  CD  ARG A  14   -15.077   4.572  30.606  1.00 17.48  A  C
ATOM   5025  NE  ARG A  14   -13.738   4.519  30.019  1.00 20.64  A  N
ATOM   5026  CZ  ARG A  14   -12.890   3.499  30.132  1.00 22.84  A  C
ATOM   5027  NH1 ARG A  14   -13.224   2.410  30.817  1.00 23.14  A  N
ATOM   5028  NH2 ARG A  14   -11.696   3.575  29.559  1.00 23.88  A  N
ATOM   5029  C   ARG A  14   -18.058   7.809  33.049  1.00 11.90  A  C
ATOM   5030  O   ARG A  14   -18.353   8.511  32.087  1.00 12.49  A  O
ATOM   5031  N   ALA A  15   -18.871   7.637  34.084  1.00 12.15  A  N
ATOM   5032  CA  ALA A  15   -20.190   8.263  34.118  1.00 12.60  A  C
ATOM   5033  CB  ALA A  15   -21.206   7.305  34.762  1.00 13.45  A  C
ATOM   5034  C   ALA A  15   -20.199   9.592  34.866  1.00 11.68  A  C
ATOM   5035  O   ALA A  15   -21.085  10.423  34.658  1.00 11.89  A  O
ATOM   5036  N   GLU A  16   -19.209   9.795  35.727  1.00 13.81  A  N
ATOM   5037  CA  GLU A  16   -19.141  11.007  36.534  1.00 13.28  A  C
ATOM   5038  CB  GLU A  16   -17.877  10.986  37.399  1.00 12.67  A  C
ATOM   5039  CG  GLU A  16   -17.971  11.841  38.672  1.00 13.36  A  C
ATOM   5040  CD  GLU A  16   -19.146  11.457  39.575  1.00 13.41  A  C
ATOM   5041  OE1 GLU A  16   -19.695  10.345  39.422  1.00 12.47  A  O
ATOM   5042  OE2 GLU A  16   -19.512  12.266  40.452  1.00 14.67  A  O
ATOM   5043  C   GLU A  16   -19.216  12.314  35.748  1.00 13.25  A  C
ATOM   5044  O   GLU A  16   -19.903  13.245  36.167  1.00 11.55  A  O
ATOM   5045  N   ILE A  17   -18.521  12.393  34.614  1.00 12.65  A  N
ATOM   5046  CA  ILE A  17   -18.549  13.621  33.823  1.00 12.45  A  C
ATOM   5047  CB  ILE A  17   -17.659  13.507  32.548  1.00 11.09  A  C
ATOM   5048  CG2 ILE A  17   -18.158  12.384  31.642  1.00  9.92  A  C
ATOM   5049  CG1 ILE A  17   -17.663  14.836  31.790  1.00 11.02  A  C
ATOM   5050  CD1 ILE A  17   -17.127  16.025  32.594  1.00 13.12  A  C
ATOM   5051  C   ILE A  17   -19.981  13.984  33.430  1.00 12.64  A  C
ATOM   5052  O   ILE A  17   -20.348  15.155  33.421  1.00 13.53  A  O
ATOM   5242  N   TRP A  39   -24.802  -7.318  35.073  1.00 35.03  A  N
ATOM   5243  CA  TRP A  39   -24.074  -6.905  33.874  1.00 33.95  A  C
ATOM   5244  CB  TRP A  39   -22.586  -6.705  34.193  1.00 30.71  A  C
ATOM   5245  CG  TRP A  39   -21.787  -6.208  33.021  1.00 27.71  A  C
ATOM   5246  CD2 TRP A  39   -22.182  -5.206  32.072  1.00 26.24  A  C
ATOM   5247  CE2 TRP A  39   -21.134  -5.085  31.130  1.00 27.24  A  C
ATOM   5248  CE3 TRP A  39   -23.319  -4.401  31.925  1.00 25.00  A  C
ATOM   5249  CD1 TRP A  39   -20.549  -6.637  32.630  1.00 28.16  A  C
ATOM   5250  NE1 TRP A  39   -20.152  -5.969  31.493  1.00 28.63  A  N
ATOM   5251  CZ2 TRP A  39   -21.191  -4.191  30.054  1.00 26.14  A  C
ATOM   5252  CZ3 TRP A  39   -23.377  -3.511  30.850  1.00 24.88  A  C
ATOM   5253  CH2 TRP A  39   -22.318  -3.416  29.931  1.00 25.30  A  C
ATOM   5254  C   TRP A  39   -24.217  -7.861  32.683  1.00 34.33  A  C
ATOM   5255  O   TRP A  39   -24.633  -7.451  31.600  1.00 34.30  A  O
ATOM   5256  N   PRO A  40   -23.880  -9.149  32.869  1.00 35.19  A  N
ATOM   5257  CD  PRO A  40   -23.513  -9.824  34.128  1.00 35.28  A  C
ATOM   5258  CA  PRO A  40   -23.985 -10.120  31.775  1.00 35.54  A  C
ATOM   5259  CB  PRO A  40   -23.906 -11.460  32.499  1.00 36.12  A  C
ATOM   5260  CG  PRO A  40   -22.984 -11.156  33.638  1.00 36.50  A  C
ATOM   5261  C   PRO A  40   -25.259  -9.985  30.946  1.00 35.56  A  C
ATOM   5262  O   PRO A  40   -25.200  -9.824  29.727  1.00 36.61  A  O
ATOM   5263  N   GLU A  41   -26.406 -10.043  31.614  1.00 34.82  A  N
ATOM   5264  CA  GLU A  41   -27.693  -9.942  30.935  1.00 35.20  A  C
ATOM   5265  CB  GLU A  41   -28.833 -10.189  31.931  1.00 37.14  A  C
ATOM   5266  CG  GLU A  41   -30.221 -10.044  31.328  1.00 41.54  A  C
ATOM   5267  CD  GLU A  41   -30.489 -11.046  30.219  1.00 44.14  A  C
ATOM   5268  OE1 GLU A  41   -31.529 -10.915  29.536  1.00 46.32  A  O
ATOM   5269  OE2 GLU A  41   -29.665 -11.967  30.030  1.00 45.36  A  O
ATOM   5270  C   GLU A  41   -27.911  -8.603  30.237  1.00 33.75  A  C
ATOM   5271  O   GLU A  41   -28.460  -8.553  29.135  1.00 34.40  A  O
ATOM   5272  N   ILE A  42   -27.483  -7.521  30.880  1.00 31.53  A  N
ATOM   5273  CA  ILE A  42   -27.648  -6.181  30.322  1.00 28.99  A  C
ATOM   5274  CB  ILE A  42   -27.401  -5.106  31.402  1.00 28.48  A  C
ATOM   5275  CG2 ILE A  42   -27.689  -3.721  30.833  1.00 27.91  A  C
ATOM   5276  CG1 ILE A  42   -28.304  -5.369  32.608  1.00 27.61  A  C
ATOM   5277  CD1 ILE A  42   -27.975  -4.530  33.821  1.00 29.35  A  C
ATOM   5278  C   ILE A  42   -26.709  -5.926  29.143  1.00 27.64  A  C
ATOM   5279  O   ILE A  42   -27.114  -5.355  28.129  1.00 27.10  A  O
ATOM   5280  N   LYS A  43   -25.459  -6.353  29.283  1.00 26.84  A  N
ATOM   5281  CA  LYS A  43   -24.457  -6.173  28.237  1.00 27.71  A  C
ATOM   5282  CB  LYS A  43   -23.160  -6.886  28.629  1.00 26.22  A  C
ATOM   5283  CG  LYS A  43   -22.062  -6.814  27.579  1.00 23.72  A  C
ATOM   5284  CD  LYS A  43   -20.871  -7.669  27.981  1.00 22.67  A  C
ATOM   5285  CE  LYS A  43   -19.747  -7.576  26.965  1.00 23.33  A  C
ATOM   5286  NZ  LYS A  43   -19.134  -6.217  26.936  1.00 21.56  A  N
ATOM   5287  C   LYS A  43   -24.940  -6.708  26.893  1.00 28.75  A  C
ATOM   5288  O   LYS A  43   -24.719  -6.090  25.852  1.00 28.75  A  O
ATOM   5328  N   GLY A  49   -22.268  -3.248  23.763  1.00 15.23  A  N
ATOM   5329  CA  GLY A  49   -21.927  -3.903  25.015  1.00 15.04  A  C
ATOM   5330  C   GLY A  49   -21.064  -3.144  26.005  1.00 15.33  A  C
ATOM   5331  O   GLY A  49   -20.313  -3.754  26.768  1.00 15.11  A  O
ATOM   5332  N   LYS A  50   -21.169  -1.821  26.007  1.00 13.57  A  N
ATOM   5333  CA  LYS A  50   -20.380  -1.008  26.926  1.00 14.57  A  C
ATOM   5334  CB  LYS A  50   -19.259  -0.274  26.173  1.00 15.57  A  C
ATOM   5335  CG  LYS A  50   -18.310  -1.166  25.391  1.00 18.60  A  C
ATOM   5336  CD  LYS A  50   -17.505  -2.069  26.308  1.00 21.95  A  C
ATOM   5337  CE  LYS A  50   -16.603  -2.992  25.504  1.00 24.43  A  C
ATOM   5338  NZ  LYS A  50   -15.681  -2.218  24.631  1.00 25.99  A  N
ATOM   5339  C   LYS A  50   -21.246   0.030  27.625  1.00 14.42  A  C
ATOM   5340  O   LYS A  50   -22.253   0.488  27.081  1.00 14.19  A  O
ATOM   5341  N   ILE A  51   -20.848   0.394  28.840  1.00 14.37  A  N
ATOM   5342  CA  ILE A  51   -21.553   1.416  29.597  1.00 14.74  A  C
ATOM   5343  CB  ILE A  51   -22.203   0.840  30.876  1.00 15.30  A  C
ATOM   5344  CG2 ILE A  51   -23.403  -0.008  30.497  1.00 17.79  A  C
ATOM   5345  CG1 ILE A  51   -21.187   0.020  31.675  1.00 15.08  A  C
ATOM   5346  CD1 ILE A  51   -21.764  -0.585  32.950  1.00 15.84  A  C
ATOM   5347  C   ILE A  51   -20.526   2.490  29.949  1.00 14.66  A  C
ATOM   5348  O   ILE A  51   -19.324   2.232  29.931  1.00 16.06  A  O
ATOM   5349  N   PRO A  52   -20.982   3.700  30.299  1.00 15.26  A  N
ATOM   5350  CD  PRO A  52   -20.083   4.841  30.562  1.00 16.04  A  C
ATOM   5351  CA  PRO A  52   -22.379   4.124  30.396  1.00 15.40  A  C
ATOM   5352  CB  PRO A  52   -22.276   5.409  31.197  1.00 15.83  A  C
ATOM   5353  CG  PRO A  52   -21.045   6.024  30.593  1.00 15.77  A  C
ATOM   5354  C   PRO A  52   -23.101   4.365  29.080  1.00 16.83  A  C
ATOM   5355  O   PRO A  52   -22.492   4.484  28.015  1.00 14.90  A  O
ATOM   5356  N   ILE A  53   -24.420   4.438  29.188  1.00 17.77  A  N
ATOM   5357  CA  ILE A  53   -25.288   4.730  28.067  1.00 18.90  A  C
ATOM   5358  CB  ILE A  53   -26.045   3.483  27.563  1.00 20.61  A  C
ATOM   5359  CG2 ILE A  53   -25.054   2.435  27.075  1.00 20.84  A  C
ATOM   5360  CG1 ILE A  53   -26.938   2.928  28.675  1.00 21.82  A  C
ATOM   5361  CD1 ILE A  53   -27.891   1.842  28.211  1.00 24.03  A  C
ATOM   5362  C   ILE A  53   -26.286   5.708  28.662  1.00 18.88  A  C
ATOM   5363  O   ILE A  53   -26.494   5.722  29.878  1.00 18.43  A  O
ATOM   5423  N   HIS A  62   -24.373   6.192  23.498  1.00 15.70  A  N
ATOM   5424  CA  HIS A  62   -23.236   5.561  24.160  1.00 15.77  A  C
ATOM   5425  CB  HIS A  62   -22.957   4.167  23.568  1.00 15.57  A  C
ATOM   5426  CG  HIS A  62   -22.517   4.179  22.134  1.00 14.35  A  C
ATOM   5427  CD2 HIS A  62   -21.358   3.778  21.556  1.00 15.17  A  C
ATOM   5428  ND1 HIS A  62   -23.332   4.598  21.104  1.00 17.10  A  N
ATOM   5429  CE1 HIS A  62   -22.697   4.451  19.953  1.00 14.96  A  C
ATOM   5430  NE2 HIS A  62   -21.498   3.955  20.200  1.00 15.48  A  N
ATOM   5431  C   HIS A  62   -21.988   6.437  24.080  1.00 14.50  A  C
ATOM   5432  O   HIS A  62   -22.007   7.489  23.442  1.00 13.29  A  O
ATOM   5433  N   GLN A  63   -20.913   5.997  24.734  1.00 13.87  A  N
ATOM   5434  CA  GLN A  63   -19.654   6.740  24.764  1.00 12.90  A  C
ATOM   5435  CB  GLN A  63   -19.224   7.137  23.345  1.00 12.53  A  C
ATOM   5436  CG  GLN A  63   -18.581   6.001  22.545  1.00 11.52  A  C
ATOM   5437  CD  GLN A  63   -17.268   5.533  23.160  1.00 12.20  A  C
ATOM   5438  OE1 GLN A  63   -16.730   6.176  24.062  1.00 10.43  A  O
ATOM   5439  NE2 GLN A  63   -16.741   4.421  22.664  1.00  9.56  A  N
ATOM   5440  C   GLN A  63   -19.805   7.976  25.653  1.00 13.56  A  C
ATOM   5441  O   GLN A  63   -20.476   8.947  25.289  1.00 14.92  A  O
ATOM   5442  N   SER A  64   -19.167   7.924  26.817  1.00 10.97  A  N
ATOM   5443  CA  SER A  64   -19.236   8.993  27.807  1.00 10.05  A  C
ATOM   5444  CB  SER A  64   -18.322   8.658  28.995  1.00  9.89  A  C
ATOM   5445  OG  SER A  64   -16.955   8.727  28.627  1.00  8.82  A  O
ATOM   5446  C   SER A  64   -18.932  10.411  27.323  1.00  8.80  A  C
ATOM   5447  O   SER A  64   -19.674  11.339  27.636  1.00  9.79  A  O
ATOM   5448  N   LEU A  65   -17.853  10.586  26.565  1.00  8.85  A  N
ATOM   5449  CA  LEU A  65   -17.483  11.917  26.091  1.00  8.19  A  C
ATOM   5450  CB  LEU A  65   -16.009  11.933  25.671  1.00  7.83  A  C
ATOM   5451  CG  LEU A  65   -15.054  11.409  26.757  1.00 11.60  A  C
ATOM   5452  CD1 LEU A  65   -13.618  11.479  26.253  1.00 11.43  A  C
ATOM   5453  CD2 LEU A  65   -15.220  12.226  28.041  1.00  8.48  A  C
ATOM   5454  C   LEU A  65   -18.374  12.419  24.956  1.00 10.81  A  C
ATOM   5455  O   LEU A  65   -18.539  13.627  24.779  1.00 11.65  A  O
ATOM   5662  N   ASP A  93    -9.664  14.664  25.566  1.00  7.26  A  N
ATOM   5663  CA  ASP A  93    -9.071  13.449  25.009  1.00  6.80  A  C
ATOM   5664  CB  ASP A  93    -9.016  13.526  23.476  1.00  7.94  A  C
ATOM   5665  CG  ASP A  93   -10.318  13.092  22.823  1.00  9.46  A  C
ATOM   5666  OD1 ASP A  93   -10.361  12.988  21.577  1.00 10.43  A  O
ATOM   5667  OD2 ASP A  93   -11.302  12.855  23.556  1.00  6.66  A  O
ATOM   5668  C   ASP A  93    -7.678  13.144  25.562  1.00  8.24  A  C
ATOM   5669  O   ASP A  93    -7.325  11.979  25.751  1.00  8.03  A  O
ATOM   5670  N   THR A  94    -6.879  14.179  25.808  1.00  7.87  A  N
ATOM   5671  CA  THR A  94    -5.541  13.973  26.354  1.00  7.89  A  C
ATOM   5672  CB  THR A  94    -4.753  15.305  26.444  1.00  8.49  A  C
ATOM   5673  OG1 THR A  94    -4.329  15.693  25.125  1.00  8.47  A  O
ATOM   5674  CG2 THR A  94    -3.520  15.155  27.342  1.00  8.64  A  C
ATOM   5675  C   THR A  94    -5.679  13.342  27.740  1.00  8.60  A  C
ATOM   5676  O   THR A  94    -4.912  12.455  28.110  1.00  8.25  A  O
ATOM   5677  N   LEU A  95    -6.669  13.797  28.499  1.00  8.02  A  N
ATOM   5678  CA  LEU A  95    -6.905  13.248  29.826  1.00  7.48  A  C
ATOM   5679  CB  LEU A  95    -7.884  14.135  30.606  1.00  6.39  A  C
ATOM   5680  CG  LEU A  95    -7.345  15.483  31.102  1.00  6.45  A  C
ATOM   5681  CD1 LEU A  95    -8.480  16.323  31.676  1.00  7.27  A  C
ATOM   5682  CD2 LEU A  95    -6.270  15.244  32.156  1.00  8.71  A  C
ATOM   5683  C   LEU A  95    -7.464  11.829  29.700  1.00  8.84  A  C
ATOM   5684  O   LEU A  95    -7.013  10.921  30.394  1.00  6.72  A  O
ATOM   5685  N   ASP A  96    -8.426  11.639  28.794  1.00  9.13  A  N
ATOM   5686  CA  ASP A  96    -9.042  10.328  28.600  1.00  8.40  A  C
ATOM   5687  CB  ASP A  96   -10.213  10.421  27.614  1.00  9.89  A  C
ATOM   5688  CG  ASP A  96   -11.200   9.271  27.768  1.00  8.95  A  C
ATOM   5689  OD1 ASP A  96   -11.674   9.046  28.903  1.00 11.48  A  O
ATOM   5690  OD2 ASP A  96   -11.515   8.599  26.761  1.00  8.48  A  O
ATOM   5691  C   ASP A  96    -8.029   9.294  28.113  1.00 11.25  A  C
ATOM   5692  O   ASP A  96    -8.083   8.129  28.516  1.00 11.68  A  O
ATOM   5693  N   ASP A  97    -7.107   9.714  27.249  1.00 10.40  A  N
ATOM   5694  CA  ASP A  97    -6.074   8.815  26.748  1.00 10.66  A  C
ATOM   5695  CB  ASP A  97    -5.108   9.552  25.815  1.00  9.42  A  C
ATOM   5696  CG  ASP A  97    -5.684   9.804  24.429  1.00 10.69  A  C
ATOM   5697  OD1 ASP A  97    -5.100  10.644  23.708  1.00  8.34  A  O
ATOM   5698  OD2 ASP A  97    -6.693   9.166  24.050  1.00  9.39  A  O
ATOM   5699  C   ASP A  97    -5.266   8.241  27.914  1.00 10.28  A  C
ATOM   5700  O   ASP A  97    -5.013   7.039  27.972  1.00  9.67  A  O
ATOM   5701  N   PHE A  98    -4.856   9.106  28.839  1.00 11.06  A  N
ATOM   5702  CA  PHE A  98    -4.057   8.667  29.984  1.00 13.17  A  C
ATOM   5703  CB  PHE A  98    -3.508   9.871  30.767  1.00 12.79  A  C
ATOM   5704  CG  PHE A  98    -2.540   9.487  31.861  1.00 14.46  A  C
ATOM   5705  CD1 PHE A  98    -1.365   8.800  31.558  1.00 14.40  A  C
ATOM   5706  CD2 PHE A  98    -2.817   9.781  33.191  1.00 15.98  A  C
ATOM   5707  CE1 PHE A  98    -0.480   8.409  32.568  1.00 17.26  A  C
ATOM   5708  CE2 PHE A  98    -1.938   9.394  34.214  1.00 16.31  A  C
ATOM   5709  CZ  PHE A  98    -0.769   8.706  33.899  1.00 14.31  A  C
ATOM   5710  C   PHE A  98    -4.828   7.754  30.935  1.00 14.11  A  C
ATOM   5711  O   PHE A  98    -4.308   6.731  31.381  1.00 14.82  A  O
ATOM   5712  N   MET A  99    -6.063   8.125  31.252  1.00 14.73  A  N
ATOM   5713  CA  MET A  99    -6.886   7.318  32.149  1.00 14.22  A  C
ATOM   5714  CB  MET A  99    -8.225   8.013  32.420  1.00 15.31  A  C
ATOM   5715  CG  MET A  99    -8.121   9.374  33.109  1.00 15.68  A  C
ATOM   5716  SD  MET A  99    -7.267   9.310  34.694  1.00 15.84  A  S
ATOM   5717  CE  MET A  99    -8.515   8.541  35.722  1.00 16.08  A  C
ATOM   5718  C   MET A  99    -7.150   5.939  31.548  1.00 16.86  A  C
ATOM   5719  O   MET A  99    -7.220   4.939  32.267  1.00 14.67  A  O
ATOM   5720  N   SER A 100    -7.292   5.892  30.225  1.00 16.11  A  N
ATOM   5721  CA  SER A 100    -7.561   4.641  29.523  1.00 16.96  A  C
ATOM   5722  CB  SER A 100    -8.084   4.936  28.115  1.00 16.86  A  C
ATOM   5723  OG  SER A 100    -9.356   5.556  28.184  1.00 16.40  A  O
ATOM   5724  C   SER A 100    -6.350   3.717  29.442  1.00 19.01  A  C
ATOM   5725  O   SER A 100    -6.489   2.528  29.149  1.00 19.47  A  O
ATOM   5726  N   CYS A 101    -5.166   4.262  29.697  1.00 20.58  A  N
ATOM   5727  CA  CYS A 101    -3.944   3.464  29.665  1.00 23.67  A  C
ATOM   5728  CB  CYS A 101    -2.707   4.368  29.693  1.00 26.07  A  C
ATOM   5729  SG  CYS A 101    -2.263   5.097  28.099  1.00 30.40  A  S
ATOM   5730  C   CYS A 101    -3.876   2.484  30.836  1.00 23.47  A  C
ATOM   5731  O   CYS A 101    -3.257   1.426  30.729  1.00 24.00  A  O
ATOM   5732  N   PHE A 102    -4.504   2.833  31.953  1.00 23.47  A  N
ATOM   5733  CA  PHE A 102    -4.485   1.955  33.117  1.00 24.57  A  C
ATOM   5734  CB  PHE A 102    -5.012   2.681  34.360  1.00 22.30  A  C
ATOM   5735  CG  PHE A 102    -4.128   3.798  34.832  1.00 21.46  A  C
ATOM   5736  CD1 PHE A 102    -4.099   5.014  34.158  1.00 20.64  A  C
ATOM   5737  CD2 PHE A 102    -3.313   3.631  35.949  1.00 20.02  A  C
ATOM   5738  CE1 PHE A 102    -3.267   6.055  34.590  1.00 21.12  A  C
ATOM   5739  CE2 PHE A 102    -2.480   4.662  36.387  1.00 20.36  A  C
ATOM   5740  CZ  PHE A 102    -2.458   5.875  35.705  1.00 18.32  A  C
ATOM   5741  C   PHE A 102    -5.313   0.698  32.881  1.00 25.48  A  C
ATOM   5742  O   PHE A 102    -6.423   0.765  32.358  1.00 25.08  A  O
ATOM   5743  N   PRO A 103    -4.773  -0.471  33.259  1.00 27.90  A  N
ATOM   5744  CD  PRO A 103    -3.398  -0.682  33.750  1.00 27.31  A  C
ATOM   5745  CA  PRO A 103    -5.466  -1.751  33.090  1.00 29.68  A  C
ATOM   5746  CB  PRO A 103    -4.323  -2.753  33.124  1.00 28.70  A  C
ATOM   5747  CG  PRO A 103    -3.410  -2.145  34.142  1.00 28.84  A  C
ATOM   5748  C   PRO A 103    -6.471  -1.975  34.220  1.00 31.64  A  C
ATOM   5749  O   PRO A 103    -6.208  -2.740  35.150  1.00 32.46  A  O
ATOM   5750  N   TRP A 104    -7.619  -1.308  34.132  1.00 33.14  A  N
ATOM   5751  CA  TRP A 104    -8.652  -1.416  35.157  1.00 34.92  A  C
ATOM   5752  CB  TRP A 104    -9.740  -0.360  34.936  1.00 34.59  A  C
ATOM   5753  CG  TRP A 104    -9.223   1.041  34.784  1.00 33.67  A  C
ATOM   5754  CD2 TRP A 104    -8.909   1.959  35.838  1.00 32.46  A  C
ATOM   5755  CE2 TRP A 104    -8.451   3.149  35.233  1.00 33.36  A  C
ATOM   5756  CE3 TRP A 104    -8.970   1.891  37.237  1.00 32.51  A  C
ATOM   5757  CD1 TRP A 104    -8.949   1.692  33.615  1.00 33.31  A  C
ATOM   5758  NE1 TRP A 104    -8.486   2.960  33.876  1.00 33.69  A  N
ATOM   5759  CZ2 TRP A 104    -8.057   4.265  35.980  1.00 33.19  A  C
ATOM   5760  CZ3 TRP A 104    -8.577   3.002  37.979  1.00 31.26  A  C
ATOM   5761  CH2 TRP A 104    -8.127   4.171  37.347  1.00 32.36  A  C
ATOM   5762  C   TRP A 104    -9.314  -2.787  35.225  1.00 36.55  A  C
ATOM   5763  O   TRP A 104    -9.542  -3.317  36.312  1.00 36.03  A  O
ATOM   5764  N   ALA A 105    -9.629  -3.353  34.064  1.00 39.05  A  N
ATOM   5765  CA  ALA A 105   -10.285  -4.657  34.001  1.00 41.04  A  C
ATOM   5766  CB  ALA A 105   -11.224  -4.709  32.801  1.00 41.47  A  C
ATOM   5767  C   ALA A 105    -9.293  -5.812  33.936  1.00 42.49  A  C
ATOM   5768  O   ALA A 105    -9.615  -6.891  33.436  1.00 43.00  A  O
ATOM   5769  N   GLU A 106    -8.087  -5.583  34.443  1.00 43.51  A  N
ATOM   5770  CA  GLU A 106    -7.055  -6.610  34.442  1.00 44.47  A  C
ATOM   5771  CB  GLU A 106    -5.669  -5.960  34.381  1.00 44.70  A  C
ATOM   5772  CG  GLU A 106    -4.502  -6.940  34.373  1.00 45.21  A  C
ATOM   5773  CD  GLU A 106    -4.626  -7.993  33.289  1.00 46.80  A  C
ATOM   5774  OE1 GLU A 106    -5.375  -8.974  33.490  1.00 47.31  A  O
ATOM   5775  OE2 GLU A 106    -3.982  -7.837  32.230  1.00 46.33  A  O
ATOM   5776  C   GLU A 106    -7.170  -7.483  35.688  1.00 44.69  A  C
ATOM   5777  O   GLU A 106    -7.174  -6.980  36.812  1.00 43.85  A  O
ATOM   5778  N   LYS A 107    -7.275  -8.791  35.477  1.00 46.22  A  N
ATOM   5779  CA  LYS A 107    -7.386  -9.744  36.576  1.00 47.90  A  C
ATOM   5780  CB  LYS A 107    -8.160 -10.985  36.124  1.00 48.02  A  C
ATOM   5781  CG  LYS A 107    -9.649 -10.743  35.925  1.00 48.88  A  C
ATOM   5782  CD  LYS A 107   -10.315 -10.333  37.233  1.00 49.71  A  C
ATOM   5783  CE  LYS A 107   -11.799 -10.060  37.043  1.00 50.86  A  C
ATOM   5784  NZ  LYS A 107   -12.534 -11.251  36.534  1.00 51.17  A  N
ATOM   5785  C   LYS A 107    -6.010 -10.148  37.096  1.00 48.88  A  C
ATOM   5786  O   LYS A 107    -5.847 -10.426  38.284  1.00 49.63  A  O
ATOM   5787  N   LYS A 108    -5.025 -10.179  36.204  1.00 49.39  A  N
ATOM   5788  CA  LYS A 108    -3.662 -10.534  36.584  1.00 50.95  A  C
ATOM   5789  CB  LYS A 108    -2.780 -10.649  35.338  1.00 50.92  A  C
ATOM   5790  CG  LYS A 108    -3.244 -11.706  34.349  1.00 51.30  A  C
ATOM   5791  CD  LYS A 108    -2.370 -11.744  33.100  1.00 51.21  A  C
ATOM   5792  CE  LYS A 108    -2.474 -10.450  32.306  1.00 51.88  A  C
ATOM   5793  NZ  LYS A 108    -1.733 -10.517  31.015  1.00 51.47  A  N
ATOM   5794  C   LYS A 108    -3.115  -9.452  37.514  1.00 51.93  A  C
ATOM   5795  O   LYS A 108    -2.605  -8.428  37.057  1.00 52.21  A  O
ATOM   5796  N   GLN A 109    -3.228  -9.687  38.818  1.00 53.19  A  N
ATOM   5797  CA  GLN A 109    -2.770  -8.734  39.827  1.00 54.34  A  C
ATOM   5798  CB  GLN A 109    -3.029  -9.293  41.229  1.00 55.53  A  C
ATOM   5799  CG  GLN A 109    -2.808  -8.292  42.359  1.00 57.97  A  C
ATOM   5800  CD  GLN A 109    -3.896  -7.230  42.433  1.00 59.38  A  C
ATOM   5801  OE1 GLN A 109    -3.833  -6.318  43.260  1.00 60.01  A  O
ATOM   5802  NE2 GLN A 109    -4.903  -7.349  41.572  1.00 59.24  A  N
ATOM   5803  C   GLN A 109    -1.291  -8.372  39.689  1.00 53.97  A  C
ATOM   5804  O   GLN A 109    -0.900  -7.231  39.939  1.00 54.03  A  O
ATOM   5805  N   ASP A 110    -0.473  -9.344  39.296  1.00 53.79  A  N
ATOM   5806  CA  ASP A 110     0.961  -9.120  39.136  1.00 53.28  A  C
ATOM   5807  CB  ASP A 110     1.687 -10.460  38.967  1.00 54.50  A  C
ATOM   5808  CG  ASP A 110     1.180 -11.256  37.777  1.00 56.41  A  C
ATOM   5809  OD1 ASP A 110    -0.040 -11.516  37.708  1.00 57.39  A  O
ATOM   5810  OD2 ASP A 110     2.005 -11.626  36.913  1.00 57.49  A  O
ATOM   5811  C   ASP A 110     1.276  -8.203  37.956  1.00 52.12  A  C
ATOM   5812  O   ASP A 110     2.309  -7.532  37.939  1.00 52.35  A  O
ATOM   5813  N   VAL A 111     0.381  -8.173  36.975  1.00 50.53  A  N
ATOM   5814  CA  VAL A 111     0.565  -7.340  35.792  1.00 48.09  A  C
ATOM   5815  CB  VAL A 111    -0.020  -8.032  34.541  1.00 47.90  A  C
ATOM   5816  CG1 VAL A 111     0.175  -7.153  33.313  1.00 47.07  A  C
ATOM   5817  CG2 VAL A 111     0.649  -9.382  34.343  1.00 46.18  A  C
ATOM   5818  C   VAL A 111    -0.106  -5.980  35.973  1.00 47.23  A  C
ATOM   5819  O   VAL A 111     0.392  -4.959  35.497  1.00 46.02  A  O
ATOM   5820  N   LYS A 112    -1.237  -5.974  36.670  1.00 46.23  A  N
ATOM   5821  CA  LYS A 112    -1.981  -4.746  36.918  1.00 45.70  A  C
ATOM   5822  CB  LYS A 112    -3.328  -5.076  37.563  1.00 45.91  A  C
ATOM   5823  CG  LYS A 112    -4.205  -3.866  37.828  1.00 47.00  A  C
ATOM   5824  CD  LYS A 112    -5.587  -4.288  38.294  1.00 46.65  A  C
ATOM   5825  CE  LYS A 112    -6.505  -3.093  38.472  1.00 47.06  A  C
ATOM   5826  NZ  LYS A 112    -7.882  -3.530  38.822  1.00 47.01  A  N
ATOM   5827  C   LYS A 112    -1.197  -3.793  37.815  1.00 45.36  A  C
ATOM   5828  O   LYS A 112    -1.044  -2.611  37.499  1.00 43.76  A  O
ATOM   5829  N   GLU A 113    -0.700  -4.316  38.931  1.00 45.30  A  N
ATOM   5830  CA  GLU A 113     0.065  -3.520  39.885  1.00 45.81  A  C
ATOM   5831  CB  GLU A 113     0.434  -4.377  41.100  1.00 46.58  A  C
ATOM   5832  CG  GLU A 113     0.985  -3.602  42.292  1.00 46.95  A  C
ATOM   5833  CD  GLU A 113    -0.079  -2.797  43.024  1.00 47.25  A  C
ATOM   5834  OE1 GLU A 113     0.232  -2.252  44.104  1.00 47.79  A  O
ATOM   5835  OE2 GLU A 113    -1.222  -2.708  42.526  1.00 46.47  A  O
ATOM   5836  C   GLU A 113     1.335  -2.963  39.244  1.00 45.70  A  C
ATOM   5837  O   GLU A 113     1.734  -1.832  39.520  1.00 45.29  A  O
ATOM   5838  N   GLN A 114     1.961  -3.764  38.386  1.00 45.03  A  N
ATOM   5839  CA  GLN A 114     3.188  -3.364  37.703  1.00 44.59  A  C
ATOM   5840  CB  GLN A 114     3.757  -4.554  36.919  1.00 46.95  A  C
ATOM   5841  CG  GLN A 114     5.090  -4.301  36.224  1.00 49.65  A  C
ATOM   5842  CD  GLN A 114     4.949  -3.515  34.933  1.00 51.80  A  C
ATOM   5843  OE1 GLN A 114     4.223  -3.920  34.024  1.00 54.22  A  O
ATOM   5844  NE2 GLN A 114     5.650  -2.389  34.842  1.00 52.38  A  N
ATOM   5845  C   GLN A 114     2.956  -2.179  36.767  1.00 43.31  A  C
ATOM   5846  O   GLN A 114     3.720  -1.214  36.778  1.00 43.59  A  O
ATOM   5847  N   MET A 115     1.902  -2.252  35.960  1.00 40.98  A  N
ATOM   5848  CA  MET A 115     1.586  -1.175  35.026  1.00 38.92  A  C
ATOM   5849  CB  MET A 115     0.543  -1.646  34.006  1.00 40.82  A  C
ATOM   5850  CG  MET A 115     0.066  -0.553  33.052  1.00 43.23  A  C
ATOM   5851  SD  MET A 115     1.400   0.229  32.107  1.00 46.86  A  S
ATOM   5852  CE  MET A 115     0.903  -0.150  30.414  1.00 46.99  A  C
ATOM   5853  C   MET A 115     1.080   0.073  35.750  1.00 36.12  A  C
ATOM   5854  O   MET A 115     1.414   1.195  35.366  1.00 34.59  A  O
ATOM   5855  N   PHE A 116     0.277  -0.124  36.793  1.00 33.79  A  N
ATOM   5856  CA  PHE A 116    -0.260   0.997  37.563  1.00 31.55  A  C
ATOM   5857  CB  PHE A 116    -1.101   0.496  38.740  1.00 29.74  A  C
ATOM   5858  CG  PHE A 116    -2.580   0.648  38.544  1.00 26.92  A  C
ATOM   5859  CD1 PHE A 116    -3.277  -0.205  37.697  1.00 26.13  A  C
ATOM   5860  CD2 PHE A 116    -3.280   1.647  39.214  1.00 25.49  A  C
ATOM   5861  CE1 PHE A 116    -4.652  -0.069  37.520  1.00 25.62  A  C
ATOM   5862  CE2 PHE A 116    -4.655   1.795  39.045  1.00 24.62  A  C
ATOM   5863  CZ  PHE A 116    -5.343   0.935  38.196  1.00 25.52  A  C
ATOM   5864  C   PHE A 116     0.852   1.885  38.108  1.00 31.56  A  C
ATOM   5865  O   PHE A 116     0.850   3.100  37.905  1.00 29.53  A  O
ATOM   6152  N   TYR A 152   -13.728  17.655  33.722  1.00  8.61  A  N
ATOM   6153  CA  TYR A 152   -13.021  16.402  33.504  1.00  9.79  A  C
ATOM   6154  CB  TYR A 152   -12.841  16.120  32.003  1.00  7.44  A  C
ATOM   6155  CG  TYR A 152   -12.799  14.634  31.704  1.00  8.27  A  C
ATOM   6156  CD1 TYR A 152   -13.773  13.778  32.225  1.00  8.38  A  C
ATOM   6157  CE1 TYR A 152   -13.742  12.403  31.973  1.00 10.32  A  C
ATOM   6158  CD2 TYR A 152   -11.791  14.080  30.919  1.00  5.95  A  C
ATOM   6159  CE2 TYR A 152   -11.751  12.704  30.659  1.00  8.41  A  C
ATOM   6160  CZ  TYR A 152   -12.729  11.873  31.191  1.00  8.47  A  C
ATOM   6161  OH  TYR A 152   -12.695  10.517  30.951  1.00  9.30  A  O
ATOM   6162  C   TYR A 152   -11.671  16.387  34.209  1.00 10.81  A  C
ATOM   6163  O   TYR A 152   -11.237  15.344  34.695  1.00 13.37  A  O
ATOM   6164  N   TRP A 153   -11.002  17.536  34.274  1.00 11.77  A  N
ATOM   6165  CA  TRP A 153    -9.715  17.589  34.964  1.00 12.66  A  C
ATOM   6166  CB  TRP A 153    -9.082  18.981  34.855  1.00 13.54  A  C
ATOM   6167  CG  TRP A 153    -8.073  19.251  35.950  1.00 13.64  A  C
ATOM   6168  CD2 TRP A 153    -6.880  18.503  36.230  1.00 12.79  A  C
ATOM   6169  CE2 TRP A 153    -6.280  19.084  37.372  1.00 13.87  A  C
ATOM   6170  CE3 TRP A 153    -6.260  17.400  35.629  1.00 14.97  A  C
ATOM   6171  CD1 TRP A 153    -8.143  20.228  36.906  1.00 14.04  A  C
ATOM   6172  NE1 TRP A 153    -7.071  20.132  37.763  1.00 14.10  A  N
ATOM   6173  CZ2 TRP A 153    -5.088  18.596  37.927  1.00 12.50  A  C
ATOM   6174  CZ3 TRP A 153    -5.072  16.914  36.183  1.00 14.36  A  C
ATOM   6175  CH2 TRP A 153    -4.502  17.516  37.321  1.00 14.19  A  C
ATOM   6176  C   TRP A 153    -9.878  17.232  36.441  1.00 11.85  A  C
ATOM   6177  O   TRP A 153    -9.107  16.434  36.981  1.00 12.51  A  O
ATOM   6178  N   GLU A 154   -10.883  17.817  37.089  1.00 11.73  A  N
ATOM   6179  CA  GLU A 154   -11.134  17.564  38.512  1.00 10.94  A  C
ATOM   6180  CB  GLU A 154   -12.231  18.510  39.027  1.00 11.59  A  C
ATOM   6181  CG  GLU A 154   -12.404  18.521  40.546  1.00 11.01  A  C
ATOM   6182  CD  GLU A 154   -13.332  17.431  41.059  1.00 16.21  A  C
ATOM   6183  OE1 GLU A 154   -13.328  17.170  42.284  1.00 14.24  A  O
ATOM   6184  OE2 GLU A 154   -14.078  16.842  40.248  1.00 16.08  A  O
ATOM   6185  C   GLU A 154   -11.536  16.108  38.739  1.00 11.33  A  C
ATOM   6186  O   GLU A 154   -11.134  15.477  39.725  1.00 11.71  A  O
ATOM   6187  N   ILE A 155   -12.327  15.580  37.815  1.00 10.60  A  N
ATOM   6188  CA  ILE A 155   -12.790  14.200  37.880  1.00 10.68  A  C
ATOM   6189  CB  ILE A 155   -13.847  13.951  36.774  1.00 10.77  A  C
ATOM   6190  CG2 ILE A 155   -14.071  12.459  36.564  1.00 11.39  A  C
ATOM   6191  CG1 ILE A 155   -15.148  14.671  37.154  1.00 12.20  A  C
ATOM   6192  CD1 ILE A 155   -16.192  14.711  36.048  1.00  9.68  A  C
ATOM   6193  C   ILE A 155   -11.630  13.210  37.750  1.00 11.46  A  C
ATOM   6194  O   ILE A 155   -11.493  12.292  38.567  1.00 12.61  A  O
ATOM   6195  N   CYS A 156   -10.789  13.402  36.735  1.00 10.83  A  N
ATOM   6196  CA  CYS A 156    -9.642  12.524  36.514  1.00 10.78  A  C
ATOM   6197  CB  CYS A 156    -8.964  12.856  35.179  1.00 12.57  A  C
ATOM   6198  SG  CYS A 156    -9.924  12.424  33.698  1.00 11.44  A  S
ATOM   6199  C   CYS A 156    -8.610  12.617  37.642  1.00 11.39  A  C
ATOM   6200  O   CYS A 156    -8.078  11.600  38.090  1.00 10.94  A  O
ATOM   6201  N   SER A 157    -8.327  13.836  38.096  1.00 10.71  A  N
ATOM   6202  CA  SER A 157    -7.348  14.035  39.160  1.00 11.64  A  C
ATOM   6203  CB  SER A 157    -7.005  15.526  39.312  1.00  8.14  A  C
ATOM   6204  OG  SER A 157    -8.149  16.309  39.581  1.00  8.71  A  O
ATOM   6205  C   SER A 157    -7.815  13.463  40.493  1.00 11.79  A  C
ATOM   6206  O   SER A 157    -7.000  12.976  41.280  1.00 12.03  A  O
ATOM   6207  N   THR A 158    -9.119  13.521  40.750  1.00 10.51  A  N
ATOM   6208  CA  THR A 158    -9.650  12.979  41.996  1.00 12.25  A  C
ATOM   6209  CB  THR A 158   -11.188  13.142  42.086  1.00 12.13  A  C
ATOM   6210  OG1 THR A 158   -11.512  14.507  42.379  1.00 11.92  A  O
ATOM   6211  CG2 THR A 158   -11.758  12.251  43.180  1.00 12.89  A  C
ATOM   6212  C   THR A 158    -9.303  11.497  42.089  1.00 12.30  A  C
ATOM   6213  O   THR A 158    -8.873  11.015  43.135  1.00 13.28  A  O
ATOM   6214  N   THR A 159    -9.484  10.778  40.986  1.00 11.79  A  N
ATOM   6215  CA  THR A 159    -9.189   9.352  40.949  1.00 12.60  A  C
ATOM   6216  CB  THR A 159    -9.777   8.713  39.671  1.00 12.94  A  C
ATOM   6217  OG1 THR A 159   -11.207   8.818  39.711  1.00 13.88  A  O
ATOM   6218  CG2 THR A 159    -9.383   7.243  39.570  1.00 13.31  A  C
ATOM   6219  C   THR A 159    -7.683   9.073  41.028  1.00 12.97  A  C
ATOM   6220  O   THR A 159    -7.242   8.210  41.792  1.00 13.33  A  O
ATOM   6221  N   LEU A 160    -6.891   9.801  40.247  1.00 11.91  A  N
ATOM   6222  CA  LEU A 160    -5.449   9.602  40.272  1.00 11.99  A  C
ATOM   6223  CB  LEU A 160    -4.767  10.506  39.243  1.00 11.62  A  C
ATOM   6224  CG  LEU A 160    -5.052  10.201  37.764  1.00 10.47  A  C
ATOM   6225  CD1 LEU A 160    -4.377  11.244  36.896  1.00 11.07  A  C
ATOM   6226  CD2 LEU A 160    -4.547   8.806  37.399  1.00  9.49  A  C
ATOM   6227  C   LEU A 160    -4.869   9.862  41.667  1.00 13.79  A  C
ATOM   6228  O   LEU A 160    -3.954   9.157  42.101  1.00 12.53  A  O
ATOM   6229  N   LEU A 161    -5.408  10.863  42.364  1.00 13.03  A  N
ATOM   6230  CA  LEU A 161    -4.938  11.210  43.703  1.00 13.25  A  C
ATOM   6231  CB  LEU A 161    -5.638  12.476  44.209  1.00 13.43  A  C
ATOM   6232  CG  LEU A 161    -5.137  13.820  43.672  1.00 14.45  A  C
ATOM   6233  CD1 LEU A 161    -6.127  14.924  44.045  1.00 11.48  A  C
ATOM   6234  CD2 LEU A 161    -3.751  14.118  44.237  1.00 13.53  A  C
ATOM   6235  C   LEU A 161    -5.145  10.080  44.704  1.00 15.09  A  C
ATOM   6236  O   LEU A 161    -4.415   9.979  45.691  1.00 16.09  A  O
ATOM   6237  N   VAL A 162    -6.143   9.238  44.459  1.00 14.39  A  N
ATOM   6238  CA  VAL A 162    -6.411   8.116  45.344  1.00 14.43  A  C
ATOM   6239  CB  VAL A 162    -7.700   7.366  44.938  1.00 15.83  A  C
ATOM   6240  CG1 VAL A 162    -7.769   6.019  45.655  1.00 11.08  A  C
ATOM   6241  CG2 VAL A 162    -8.925   8.207  45.287  1.00 14.62  A  C
ATOM   6242  C   VAL A 162    -5.242   7.140  45.304  1.00 15.52  A  C
ATOM   6243  O   VAL A 162    -4.861   6.579  46.329  1.00 16.41  A  O
ATOM   6244  N   PHE A 163    -4.667   6.951  44.119  1.00 14.68  A  N
ATOM   6245  CA  PHE A 163    -3.543   6.036  43.955  1.00 15.48  A  C
ATOM   6246  CB  PHE A 163    -3.660   5.286  42.624  1.00 16.17  A  C
ATOM   6247  CG  PHE A 163    -4.915   4.476  42.498  1.00 17.77  A  C
ATOM   6248  CD1 PHE A 163    -6.066   5.026  41.934  1.00 18.11  A  C
ATOM   6249  CD2 PHE A 163    -4.962   3.172  42.978  1.00 17.18  A  C
ATOM   6250  CE1 PHE A 163    -7.243   4.284  41.852  1.00 18.08  A  C
ATOM   6251  CE2 PHE A 163    -6.134   2.422  42.901  1.00 17.00  A  C
ATOM   6252  CZ  PHE A 163    -7.277   2.981  42.338  1.00 18.37  A  C
ATOM   6253  C   PHE A 163    -2.179   6.714  44.041  1.00 15.57  A  C
ATOM   6254  O   PHE A 163    -1.164   6.044  44.214  1.00 16.24  A  O
ATOM   6528  N   THR A 197   -17.099   5.832  46.606  1.00 22.13  A  N
ATOM   6529  CA  THR A 197   -16.501   4.631  46.037  1.00 20.93  A  C
ATOM   6530  CB  THR A 197   -17.228   4.228  44.740  1.00 20.53  A  C
ATOM   6531  OG1 THR A 197   -17.165   5.313  43.801  1.00 19.47  A  O
ATOM   6532  CG2 THR A 197   -18.687   3.904  45.031  1.00 19.28  A  C
ATOM   6533  C   THR A 197   -15.022   4.835  45.726  1.00 19.70  A  C
ATOM   6534  O   THR A 197   -14.532   5.964  45.709  1.00 19.73  A  O
ATOM   6535  N   LYS A 198   -14.320   3.734  45.480  1.00 18.70  A  N
ATOM   6536  CA  LYS A 198   -12.895   3.773  45.164  1.00 20.70  A  C
ATOM   6537  CB  LYS A 198   -12.321   2.354  45.158  1.00 20.27  A  C
ATOM   6538  CG  LYS A 198   -10.822   2.287  44.939  1.00 21.83  A  C
ATOM   6539  CD  LYS A 198   -10.393   0.877  44.552  1.00 24.28  A  C
ATOM   6540  CE  LYS A 198    -8.880   0.756  44.464  1.00 25.89  A  C
ATOM   6541  NZ  LYS A 198    -8.481  -0.584  43.937  1.00 28.24  A  N
ATOM   6542  C   LYS A 198   -12.646   4.419  43.800  1.00 21.33  A  C
ATOM   6543  O   LYS A 198   -11.809   5.317  43.664  1.00 20.34  A  O
ATOM   6544  N   LEU A 199   -13.377   3.949  42.793  1.00 21.84  A  N
ATOM   6545  CA  LEU A 199   -13.245   4.469  41.436  1.00 21.69  A  C
ATOM   6546  CB  LEU A 199   -12.977   3.321  40.459  1.00 23.94  A  C
ATOM   6547  CG  LEU A 199   -11.787   2.419  40.793  1.00 25.29  A  C
ATOM   6548  CD1 LEU A 199   -11.612   1.374  39.698  1.00 25.62  A  C
ATOM   6549  CD2 LEU A 199   -10.528   3.263  40.927  1.00 25.82  A  C
ATOM   6550  C   LEU A 199   -14.497   5.220  41.004  1.00 21.61  A  C
ATOM   6551  OT1 LEU A 199   -15.506   5.171  41.740  1.00 20.08  A  O
ATOM   6552  OT2 LEU A 199   -14.454   5.846  39.923  1.00 21.69  A  O
ATOM   6613  N1  GSH H 200   -14.550   5.015  25.946  1.00 13.63  H  N
ATOM   6614  CA1 GSH H 200   -15.807   4.471  26.450  1.00 13.25  H  C
ATOM   6615  C1  GSH H 200   -16.630   5.539  27.221  1.00 12.75  H  C
ATOM   6616  O11 GSH H 200   -16.085   6.603  27.529  1.00 12.96  H  O
ATOM   6617  O12 GSH H 200   -17.891   5.250  27.492  1.00 15.28  H  O
ATOM   6618  CB1 GSH H 200   -15.460   3.288  27.375  1.00 13.02  H  C
ATOM   6619  CG1 GSH H 200   -16.582   2.234  27.492  1.00 13.79  H  C
ATOM   6620  CD1 GSH H 200   -16.071   1.156  28.480  1.00 15.77  H  C
ATOM   6621  OE1 GSH H 200   -15.102   0.436  28.187  1.00 15.88  H  O
ATOM   6622  N2  GSH H 200   -16.842   0.986  29.567  1.00 14.96  H  N
ATOM   6623  CA2 GSH H 200   -16.537  -0.058  30.558  1.00 16.29  H  C
ATOM   6624  C2  GSH H 200   -17.470  -1.253  30.341  1.00 17.28  H  C
ATOM   6625  O2  GSH H 200   -18.558  -1.130  29.767  1.00 15.17  H  O
ATOM   6626  CB2 GSH H 200   -16.864   0.452  31.977  1.00 16.12  H  C
ATOM   6627  SG2 GSH H 200   -15.601   1.558  32.669  1.00 16.79  H  S
ATOM   6628  N3  GSH H 200   -16.899  -2.457  30.507  1.00 19.59  H  N
ATOM   6629  CA3 GSH H 200   -17.689  -3.694  30.640  1.00 20.55  H  C
ATOM   6630  C3  GSH H 200   -17.281  -4.655  29.543  1.00 22.53  H  C
ATOM   6631  O31 GSH H 200   -17.861  -5.761  29.526  1.00 20.65  H  O
ATOM   6632  O32 GSH H 200   -16.398  -4.285  28.728  1.00 22.35  H  O
ATOM   6708  C1  U44 X 201   -13.533  -1.851  34.292  1.00 70.39  X  C
ATOM   6709  C2  U44 X 201   -13.257  -2.563  35.604  1.00 70.70  X  C
ATOM   6710  C3  U44 X 201   -12.903  -1.371  36.540  1.00 70.14  X  C
ATOM   6711  C4  U44 X 201   -13.965  -0.313  36.092  1.00 69.11  X  C
ATOM   6712  C5  U44 X 201   -14.677  -1.086  34.944  1.00 69.81  X  C
ATOM   6713  C7  U44 X 201   -15.544  -2.216  35.493  1.00 70.48  X  C
ATOM   6714  O6  U44 X 201   -14.532  -3.138  35.915  1.00 70.45  X  O
ATOM   6715  C14 U44 X 201   -13.413   1.005  35.576  1.00 66.59  X  C
ATOM   6716  C16 U44 X 201   -13.394   2.213  36.191  1.00 62.13  X  C
ATOM   6717  C18 U44 X 201   -12.818   3.501  35.639  1.00 58.63  X  C
ATOM   6718  C20 U44 X 201   -12.819   3.574  34.090  1.00 55.24  X  C
ATOM   6719  C21 U44 X 201   -11.964   4.730  33.525  1.00 50.86  X  C
ATOM   6720  C24 U44 X 201   -12.612   6.108  33.730  1.00 48.35  X  C
ATOM   6721  C27 U44 X 201   -11.669   7.268  33.392  1.00 45.75  X  C
ATOM   6722  C30 U44 X 201   -12.193   8.608  33.921  1.00 40.82  X  C
ATOM   6723  O36 U44 X 201   -11.498   3.620  36.106  1.00 60.26  X  O
ATOM   6724  C39 U44 X 201   -12.884  -1.741  38.072  1.00 70.91  X  C
ATOM   6725  C41 U44 X 201   -14.205  -1.601  38.816  1.00 72.25  X  C
ATOM   6726  C44 U44 X 201   -14.430  -1.700  40.146  1.00 73.15  X  C
ATOM   6727  C46 U44 X 201   -13.410  -1.976  41.224  1.00 73.77  X  C
ATOM   6728  C48 U44 X 201   -13.173  -3.470  41.449  1.00 74.30  X  C
ATOM   6729  C51 U44 X 201   -11.671  -3.799  41.522  1.00 74.31  X  C
ATOM   6730  C54 U44 X 201   -11.421  -5.228  42.015  1.00 74.04  X  C
ATOM   6731  O57 U44 X 201   -10.109  -5.499  42.071  1.00 74.59  X  O
ATOM   6732  O58 U44 X 201   -12.270  -6.010  42.314  1.00 73.77  X  O
ATOM   6734 MG+2 MG2 M 902   -10.576   8.691  23.110  1.00 14.30      M
MG+2
ATOM   6741  OH2 WAT S   7   -12.220  10.128  23.608  1.00 19.80  S  O
ATOM   6742  OH2 WAT S   8    -9.999   7.991  24.913  1.00 16.06  S  O
ATOM   6743  OH2 WAT S   9    -9.577   7.058  22.052  1.00  9.47  S  O
ATOM   6744  OH2 WAT S  10   -11.304   9.428  21.145  1.00 20.89  S  O
ATOM   6745  OH2 WAT S  11    -8.905   9.998  22.706  1.00  6.56  S  O
ATOM   6746  OH2 WAT S  12   -12.342   7.553  23.132  1.00  5.11  S  O
ATOM   6755  OH2 WAT S  21   -16.321  10.562  33.715  1.00 12.00  S  O
ATOM   6760  OH2 WAT S  26   -22.235   0.646  24.380  1.00  8.59  S  O
ATOM   6790  OH2 WAT S  56   -19.949   3.890  26.386  1.00 14.06  S  O
ATOM   6822  OH2 WAT S  88   -15.088   1.355  23.422  1.00 11.11  S  O
ATOM   6845  OH2 WAT S 112   -14.218   9.379  37.460  1.00 10.60  S  O
ATOM   6848  OH2 WAT S 115   -30.009   4.031  30.556  1.00 20.47  S  O
ATOM   6856  OH2 WAT S 123   -21.028   9.378  41.645  1.00 13.15  S  O
ATOM   6857  OH2 WAT S 124   -17.894   1.227  22.644  1.00 11.10  S  O
ATOM   6869  OH2 WAT S 136   -13.700  11.068  39.668  1.00 12.06  S  O
ATOM   6873  OH2 WAT S 140   -16.131   8.790  24.586  1.00 10.01  S  O
ATOM   6881  OH2 WAT S 148   -14.575  -2.288  28.277  1.00 24.82  S  O
ATOM   6908  OH2 WAT S 177   -20.137   2.340  24.117  1.00  8.16  S  O
ATOM   6925  OH2 WAT S 195   -14.246  -0.057  25.568  1.00 26.38  S  O
ATOM   6936  OH2 WAT S 206   -14.383  -0.255  21.039  1.00 21.10  S  O
ATOM   7014  OH2 WAT S 294   -25.323   5.733  36.748  1.00 14.27  S  O
ATOM   7015  OH2 WAT S 295    -5.015   5.528  25.654  1.00 25.26  S  O
ATOM   7026  OH2 WAT S 306   -12.125  -1.788  22.440  1.00 16.05  S  O
ATOM   7091  OH2 WAT S 374   -19.550   6.899  43.308  1.00 15.60  S  O
ATOM   7153  OH2 WAT S 445   -10.080  -6.158  38.144  1.00 40.05  S  O
ATOM   7166  OH2 WAT S 461   -11.181  -0.389  24.993  1.00 32.17  S  O
ATOM   7189  OH2 WAT S 489   -11.757   5.269  27.058  1.00 17.40  S  O
ATOM   7201  OH2 WAT S 504   -21.955  -1.663  40.073  1.00 22.05  S  O
ATOM   7212  OH2 WAT S 521   -17.307  -1.765  21.966  1.00 22.00  S  O
ATOM   7233  OH2 WAT S 545    -7.572  -3.899  31.498  1.00 31.88  S  O
ATOM   7238  OH2 WAT S 550   -16.631  -4.218  44.114  1.00 28.79  S  O
ATOM   7255  OH2 WAT S 571   -16.386  -5.314  21.770  1.00 19.46  S  O
ATOM   7274  OH2 WAT S 595   -17.930  -3.842  20.217  1.00 18.12  S  O
ATOM   7276  OH2 WAT S 597   -13.769   7.885  25.487  1.00 10.50  S  O
ATOM   7288  OH2 WAT S 616   -12.729   7.435  38.117  1.00 23.58  S  O
ATOM   7322  OH2 WAT S 668    -8.910   2.771  24.376  1.00 47.74  S  O
ATOM   7353  OH2 WAT S 728   -24.717   0.462  23.216  1.00 26.35  S  O
ATOM   7375  OH2 WAT S 764   -15.374   9.583  31.111  1.00 11.02  S  O
ATOM   7389  OH2 WAT S 820    -9.060  -6.376  26.123  1.00 42.71  S  O
ATOM   7396  OH2 WAT S 831   -23.318  -6.716  23.568  1.00 37.58  S  O
ATOM   7426  OH2 WAT S 901   -21.607  -1.120  45.347  1.00 32.16  S  O
ATOM   7495  OH2 WAT S1295   -10.054   5.104  25.040  1.00 30.17  S  O
ATOM   7535  OH2 WAT S1341   -11.308  -8.312  40.840  1.00 33.98  S  O
ATOM   7536  OH2 WAT S1342   -18.306  -0.785  45.664  1.00 23.47  S  O
ATOM   7548  OH2 WAT S1355   -11.195   6.225  36.412  1.00 22.59  S  O
ATOM   7552  OH2 WAT S1361   -19.290  -9.723  41.426  1.00 33.42  S  O
ATOM   7553  OH2 WAT S1362   -20.599  -6.591  22.350  1.00 29.05  S  O
ATOM   7559  OH2 WAT S1368    -9.450   1.544  29.448  1.00 32.22  S  O
ATOM   7560  OH2 WAT S1369    -6.410  -0.567  29.306  1.00 38.08  S  O
ATOM   7566  OH2 WAT S1376   -14.934  13.298  41.070  1.00 13.87  S  O
ATOM   7569  OH2 WAT S1380   -17.170   8.649  45.004  1.00 13.87  S  O
ATOM   7585  OH2 WAT S1398   -13.501   6.967  29.029  1.00 12.91  S  O
ATOM   7586  OH2 WAT S1399   -11.476  -0.026  31.088  1.00 30.86  S  O
ATOM   7591  OH2 WAT S1407   -15.761  -4.514  39.356  1.00 51.81  S  O
ATOM   7592  OH2 WAT S1408   -15.589  -5.579  35.465  1.00 42.90  S  O
ATOM   7593  OH2 WAT S1409    -7.748  -3.886  41.337  1.00 28.05  S  O
ATOM   7681  OH2 WAT S1560   -14.609   1.320  43.058  1.00 31.74  S  O
ATOM   7688  OH2 WAT S1571   -18.720  -5.226  24.140  1.00 37.27  S  O
ATOM   7724  OH2 WAT S1614    -7.499   6.183  23.535  1.00 42.36  S  O
ATOM   7745  OH2 WAT S1636    -9.600  -1.548  39.202  1.00 43.85  S  O
【００５３】
【表７】
ヒト由来造血器型ＰＧＤＳカルシウム型と、グルタチオン及びチバクロンブルーとの複合体の３次元構造座標
ATOM   1690  N   TYR A   8      -2.882 -27.583  10.962  1.00  8.07   A
ATOM   1691  CA  TYR A   8      -2.803 -26.193  11.399  1.00  8.37   A
ATOM   1692  CB  TYR A   8      -1.457 -25.586  10.986  1.00  8.12   A
ATOM   1693  CG  TYR A   8      -1.151 -24.248  11.627  1.00  8.19   A
ATOM   1694  CD1 TYR A   8      -1.019 -24.131  13.013  1.00  7.49   A
ATOM   1695  CE1 TYR A   8      -0.726 -22.906  13.605  1.00  7.97   A
ATOM   1696  CD2 TYR A   8      -0.983 -23.099  10.850  1.00  8.28   A
ATOM   1697  CE2 TYR A   8      -0.688 -21.869  11.438  1.00  7.81   A
ATOM   1698  CZ  TYR A   8      -0.562 -21.783  12.811  1.00  8.21   A
ATOM   1699  OH  TYR A   8      -0.268 -20.575  13.381  1.00  8.12   A
ATOM   1700  C   TYR A   8      -3.932 -25.418  10.728  1.00  8.79   A
ATOM   1701  O   TYR A   8      -4.689 -25.979   9.943  1.00  8.57   A
ATOM   1702  N   PHE A   9      -4.047 -24.134  11.051  1.00  9.51   A
ATOM   1703  CA  PHE A   9      -5.069 -23.291  10.446  1.00 10.44   A
ATOM   1704  CB  PHE A   9      -5.179 -21.963  11.191  1.00 10.48   A
ATOM   1705  CG  PHE A   9      -5.739 -22.092  12.572  1.00 11.15   A
ATOM   1706  CD1 PHE A   9      -5.022 -21.633  13.672  1.00 11.38   A
ATOM   1707  CD2 PHE A   9      -6.976 -22.684  12.776  1.00 10.92   A
ATOM   1708  CE1 PHE A   9      -5.539 -21.768  14.960  1.00 11.88   A
ATOM   1709  CE2 PHE A   9      -7.497 -22.823  14.052  1.00 11.75   A
ATOM   1710  CZ  PHE A   9      -6.778 -22.364  15.148  1.00 11.23   A
ATOM   1711  C   PHE A   9      -4.654 -23.010   9.011  1.00 11.01   A
ATOM   1712  O   PHE A   9      -3.567 -23.405   8.584  1.00 10.55   A
ATOM   1713  N   ASN A  10      -5.518 -22.325   8.269  1.00 11.11   A
ATOM   1714  CA  ASN A  10      -5.204 -21.977   6.887  1.00 11.58   A
ATOM   1715  CB  ASN A  10      -6.481 -21.836   6.048  1.00 11.02   A
ATOM   1716  CG  ASN A  10      -6.192 -21.414   4.615  1.00 12.05   A
ATOM   1717  OD1 ASN A  10      -5.142 -21.747   4.049  1.00 11.74   A
ATOM   1718  ND2 ASN A  10      -7.130 -20.690   4.012  1.00 12.36   A
ATOM   1719  C   ASN A  10      -4.439 -20.655   6.889  1.00 11.87   A
ATOM   1720  O   ASN A  10      -4.998 -19.591   6.618  1.00 11.89   A
ATOM   1721  N   MET A  11      -3.163 -20.732   7.252  1.00 12.14   A
ATOM   1722  CA  MET A  11      -2.281 -19.570   7.276  1.00 12.22   A
ATOM   1723  CB  MET A  11      -2.681 -18.571   8.391  1.00 13.94   A
ATOM   1724  CG  MET A  11      -2.627 -19.064   9.826  1.00 16.67   A
ATOM   1725  SD  MET A  11      -3.026 -17.743  11.102  1.00 19.82   A
ATOM   1726  CE  MET A  11      -4.782 -17.673  10.947  1.00 19.20   A
ATOM   1727  C   MET A  11      -0.849 -20.065   7.455  1.00 11.51   A
ATOM   1728  O   MET A  11      -0.619 -21.250   7.759  1.00 10.85   A
ATOM   1729  N   ARG A  12       0.109 -19.180   7.208  1.00  9.73   A
ATOM   1730  CA  ARG A  12       1.508 -19.544   7.373  1.00  9.30   A
ATOM   1731  CB  ARG A  12       2.419 -18.405   6.880  1.00  9.27   A
ATOM   1732  CG  ARG A  12       2.249 -18.071   5.381  1.00  9.28   A
ATOM   1733  CD  ARG A  12       3.317 -17.072   4.886  1.00  9.18   A
ATOM   1734  NE  ARG A  12       3.265 -15.815   5.625  1.00  9.17   A
ATOM   1735  CZ  ARG A  12       2.303 -14.905   5.491  1.00  9.26   A
ATOM   1736  NH1 ARG A  12       1.311 -15.106   4.633  1.00  9.26   A
ATOM   1737  NH2 ARG A  12       2.320 -13.806   6.230  1.00  7.97   A
ATOM   1738  C   ARG A  12       1.692 -19.802   8.868  1.00  8.69   A
ATOM   1739  O   ARG A  12       1.922 -20.936   9.294  1.00  7.11   A
ATOM   1740  N   GLY A  13       1.568 -18.742   9.660  1.00  8.23   A
ATOM   1741  CA  GLY A  13       1.686 -18.879  11.102  1.00  8.26   A
ATOM   1742  C   GLY A  13       2.843 -19.731  11.591  1.00  7.95   A
ATOM   1743  O   GLY A  13       3.942 -19.685  11.038  1.00  8.28   A
ATOM   1744  N   ARG A  14       2.587 -20.533  12.620  1.00  8.33   A
ATOM   1745  CA  ARG A  14       3.623 -21.374  13.210  1.00  8.64   A
ATOM   1746  CB  ARG A  14       3.284 -21.628  14.676  1.00 10.55   A
ATOM   1747  CG  ARG A  14       3.169 -20.337  15.470  1.00 14.00   A
ATOM   1748  CD  ARG A  14       2.974 -20.601  16.955  1.00 16.89   A
ATOM   1749  NE  ARG A  14       4.069 -20.046  17.745  1.00 20.03   A
ATOM   1750  CZ  ARG A  14       5.312 -20.519  17.739  1.00 20.80   A
ATOM   1751  NH1 ARG A  14       5.629 -21.561  16.988  1.00 22.98   A
ATOM   1752  NH2 ARG A  14       6.242 -19.951  18.482  1.00 21.79   A
ATOM   1753  C   ARG A  14       3.894 -22.686  12.500  1.00  8.02   A
ATOM   1754  O   ARG A  14       4.787 -23.438  12.888  1.00  7.13   A
ATOM   1755  N   ALA A  15       3.136 -22.958  11.445  1.00  7.13   A
ATOM   1756  CA  ALA A  15       3.330 -24.197  10.706  1.00  6.67   A
ATOM   1757  CB  ALA A  15       1.987 -24.747  10.262  1.00  6.00   A
ATOM   1758  C   ALA A  15       4.221 -23.975   9.497  1.00  6.29   A
ATOM   1759  O   ALA A  15       4.765 -24.925   8.934  1.00  6.25   A
ATOM   1760  N   GLU A  16       4.383 -22.714   9.106  1.00  6.29   A
ATOM   1761  CA  GLU A  16       5.176 -22.402   7.915  1.00  5.84   A
ATOM   1762  CB  GLU A  16       5.209 -20.890   7.678  1.00  4.97   A
ATOM   1763  CG  GLU A  16       5.524 -20.485   6.235  1.00  5.83   A
ATOM   1764  CD  GLU A  16       4.520 -21.037   5.205  1.00  6.62   A
ATOM   1765  OE1 GLU A  16       3.472 -21.597   5.601  1.00  6.92   A
ATOM   1766  OE2 GLU A  16       4.782 -20.883   3.984  1.00  6.47   A
ATOM   1767  C   GLU A  16       6.597 -22.952   7.940  1.00  5.58   A
ATOM   1768  O   GLU A  16       7.085 -23.435   6.912  1.00  6.05   A
ATOM   1769  N   ILE A  17       7.260 -22.890   9.095  1.00  5.19   A
ATOM   1770  CA  ILE A  17       8.631 -23.382   9.203  1.00  5.07   A
ATOM   1771  CB  ILE A  17       9.222 -23.154  10.658  1.00  4.92   A
ATOM   1772  CG2 ILE A  17       8.396 -23.885  11.716  1.00  4.41   A
ATOM   1773  CG1 ILE A  17      10.668 -23.634  10.717  1.00  4.64   A
ATOM   1774  CD1 ILE A  17      11.531 -23.053   9.616  1.00  5.86   A
ATOM   1775  C   ILE A  17       8.676 -24.858   8.805  1.00  4.81   A
ATOM   1776  O   ILE A  17       9.588 -25.305   8.103  1.00  4.95   A
ATOM   1966  N   TRP A  39     -11.923 -26.095  14.978  1.00 32.28   A
ATOM   1967  CA  TRP A  39     -10.853 -26.045  15.967  1.00 32.36   A
ATOM   1968  CB  TRP A  39     -10.353 -24.604  16.130  1.00 32.57   A
ATOM   1969  CG  TRP A  39      -9.352 -24.410  17.236  1.00 32.92   A
ATOM   1970  CD2 TRP A  39      -8.212 -25.232  17.526  1.00 33.08   A
ATOM   1971  CE2 TRP A  39      -7.565 -24.666  18.648  1.00 33.25   A
ATOM   1972  CE3 TRP A  39      -7.676 -26.392  16.950  1.00 33.06   A
ATOM   1973  CD1 TRP A  39      -9.345 -23.408  18.164  1.00 33.31   A
ATOM   1974  NE1 TRP A  39      -8.277 -23.554  19.015  1.00 32.95   A
ATOM   1975  CZ2 TRP A  39      -6.407 -25.220  19.208  1.00 33.30   A
ATOM   1976  CZ3 TRP A  39      -6.522 -26.944  17.508  1.00 33.28   A
ATOM   1977  CH2 TRP A  39      -5.902 -26.353  18.627  1.00 33.07   A
ATOM   1978  C   TRP A  39     -11.305 -26.596  17.323  1.00 32.24   A
ATOM   1979  O   TRP A  39     -10.653 -27.471  17.891  1.00 31.88   A
ATOM   1980  N   PRO A  40     -12.437 -26.098  17.850  1.00 32.29   A
ATOM   1981  CD  PRO A  40     -13.335 -25.084  17.264  1.00 32.39   A
ATOM   1982  CA  PRO A  40     -12.953 -26.557  19.147  1.00 32.22   A
ATOM   1983  CB  PRO A  40     -14.347 -25.943  19.198  1.00 32.41   A
ATOM   1984  CG  PRO A  40     -14.155 -24.651  18.462  1.00 32.65   A
ATOM   1985  C   PRO A  40     -12.975 -28.077  19.343  1.00 31.96   A
ATOM   1986  O   PRO A  40     -12.489 -28.579  20.355  1.00 31.96   A
ATOM   1987  N   GLU A  41     -13.527 -28.810  18.382  1.00 31.78   A
ATOM   1988  CA  GLU A  41     -13.599 -30.263  18.503  1.00 31.71   A
ATOM   1989  CB  GLU A  41     -14.590 -30.831  17.477  1.00 32.59   A
ATOM   1990  CG  GLU A  41     -16.039 -30.398  17.728  1.00 34.12   A
ATOM   1991  CD  GLU A  41     -17.008 -30.864  16.651  1.00 34.74   A
ATOM   1992  OE1 GLU A  41     -18.136 -30.324  16.602  1.00 35.16   A
ATOM   1993  OE2 GLU A  41     -16.650 -31.762  15.859  1.00 35.71   A
ATOM   1994  C   GLU A  41     -12.248 -30.965  18.374  1.00 31.20   A
ATOM   1995  O   GLU A  41     -12.026 -32.006  18.994  1.00 31.36   A
ATOM   1996  N   ILE A  42     -11.341 -30.402  17.581  1.00 30.36   A
ATOM   1997  CA  ILE A  42     -10.024 -31.008  17.404  1.00 29.44   A
ATOM   1998  CB  ILE A  42      -9.329 -30.477  16.132  1.00 29.45   A
ATOM   1999  CG2 ILE A  42      -7.893 -30.971  16.070  1.00 29.10   A
ATOM   2000  CG1 ILE A  42     -10.098 -30.946  14.896  1.00 29.17   A
ATOM   2001  CD1 ILE A  42      -9.533 -30.435  13.587  1.00 29.41   A
ATOM   2002  C   ILE A  42      -9.133 -30.743  18.614  1.00 29.13   A
ATOM   2003  O   ILE A  42      -8.395 -31.621  19.064  1.00 28.94   A
ATOM   2004  N   LYS A  43      -9.215 -29.527  19.140  1.00 28.55   A
ATOM   2005  CA  LYS A  43      -8.427 -29.129  20.294  1.00 28.30   A
ATOM   2006  CB  LYS A  43      -8.860 -27.739  20.757  1.00 28.78   A
ATOM   2007  CG  LYS A  43      -8.047 -27.185  21.911  1.00 29.29   A
ATOM   2008  CD  LYS A  43      -8.485 -25.778  22.266  1.00 29.95   A
ATOM   2009  CE  LYS A  43      -7.585 -25.184  23.332  1.00 30.31   A
ATOM   2010  NZ  LYS A  43      -7.992 -23.795  23.662  1.00 31.39   A
ATOM   2011  C   LYS A  43      -8.554 -30.120  21.452  1.00 27.83   A
ATOM   2012  O   LYS A  43      -7.565 -30.471  22.088  1.00 27.33   A
ATOM   2052  N   GLY A  49      -3.879 -29.189  23.684  1.00 18.08   A
ATOM   2053  CA  GLY A  49      -4.819 -28.316  23.011  1.00 17.77   A
ATOM   2054  C   GLY A  49      -4.205 -27.233  22.144  1.00 17.36   A
ATOM   2055  O   GLY A  49      -4.742 -26.134  22.055  1.00 17.62   A
ATOM   2056  N   LYS A  50      -3.087 -27.533  21.492  1.00 16.57   A
ATOM   2057  CA  LYS A  50      -2.444 -26.544  20.635  1.00 15.44   A
ATOM   2058  CB  LYS A  50      -1.252 -25.901  21.357  1.00 16.66   A
ATOM   2059  CG  LYS A  50      -1.576 -25.229  22.697  1.00 19.15   A
ATOM   2060  CD  LYS A  50      -2.571 -24.078  22.546  1.00 20.62   A
ATOM   2061  CE  LYS A  50      -2.752 -23.310  23.863  1.00 22.03   A
ATOM   2062  NZ  LYS A  50      -1.454 -22.751  24.383  1.00 23.09   A
ATOM   2063  C   LYS A  50      -1.962 -27.136  19.308  1.00 14.12   A
ATOM   2064  O   LYS A  50      -1.634 -28.319  19.214  1.00 12.86   A
ATOM   2065  N   ILE A  51      -1.935 -26.300  18.280  1.00 12.71   A
ATOM   2066  CA  ILE A  51      -1.442 -26.709  16.976  1.00 11.10   A
ATOM   2067  CB  ILE A  51      -2.556 -26.696  15.904  1.00 11.18   A
ATOM   2068  CG2 ILE A  51      -3.365 -27.995  15.981  1.00  9.64   A
ATOM   2069  CG1 ILE A  51      -3.448 -25.464  16.085  1.00 11.01   A
ATOM   2070  CD1 ILE A  51      -4.506 -25.325  15.031  1.00 11.08   A
ATOM   2071  C   ILE A  51      -0.361 -25.690  16.641  1.00 11.44   A
ATOM   2072  O   ILE A  51      -0.312 -24.616  17.240  1.00 11.87   A
ATOM   2073  N   PRO A  52       0.490 -25.983  15.651  1.00 10.86   A
ATOM   2074  CD  PRO A  52       1.653 -25.134  15.342  1.00 10.26   A
ATOM   2075  CA  PRO A  52       0.506 -27.193  14.826  1.00  9.60   A
ATOM   2076  CB  PRO A  52       1.479 -26.827  13.715  1.00 10.27   A
ATOM   2077  CG  PRO A  52       2.505 -26.052  14.470  1.00 10.74   A
ATOM   2078  C   PRO A  52       0.917 -28.512  15.473  1.00  9.74   A
ATOM   2079  O   PRO A  52       1.654 -28.551  16.457  1.00  9.94   A
ATOM   2080  N   ILE A  53       0.429 -29.595  14.890  1.00  9.16   A
ATOM   2081  CA  ILE A  53       0.802 -30.928  15.316  1.00  9.11   A
ATOM   2082  CB  ILE A  53      -0.356 -31.724  15.961  1.00  9.49   A
ATOM   2083  CG2 ILE A  53      -0.587 -31.248  17.399  1.00  9.33   A
ATOM   2084  CG1 ILE A  53      -1.625 -31.588  15.116  1.00 10.59   A
ATOM   2085  CD1 ILE A  53      -2.661 -32.627  15.451  1.00 10.74   A
ATOM   2086  C   ILE A  53       1.209 -31.624  14.028  1.00  8.87   A
ATOM   2087  O   ILE A  53       0.795 -31.217  12.937  1.00  8.80   A
ATOM   2147  N   HIS A  62       4.066 -32.477  18.677  1.00  7.17   A
ATOM   2148  CA  HIS A  62       3.585 -31.113  18.831  1.00  7.13   A
ATOM   2149  CB  HIS A  62       2.587 -30.991  20.005  1.00  6.95   A
ATOM   2150  CG  HIS A  62       3.182 -31.270  21.350  1.00  7.27   A
ATOM   2151  CD2 HIS A  62       3.456 -30.449  22.392  1.00  6.74   A
ATOM   2152  ND1 HIS A  62       3.557 -32.535  21.750  1.00  7.14   A
ATOM   2153  CE1 HIS A  62       4.030 -32.482  22.982  1.00  7.45   A
ATOM   2154  NE2 HIS A  62       3.981 -31.228  23.394  1.00  7.97   A
ATOM   2155  C   HIS A  62       4.749 -30.134  19.018  1.00  6.81   A
ATOM   2156  O   HIS A  62       5.903 -30.550  19.138  1.00  6.11   A
ATOM   2157  N   GLN A  63       4.416 -28.840  19.036  1.00  6.34   A
ATOM   2158  CA  GLN A  63       5.371 -27.738  19.167  1.00  6.36   A
ATOM   2159  CB  GLN A  63       6.378 -27.990  20.295  1.00  6.62   A
ATOM   2160  CG  GLN A  63       5.846 -27.668  21.677  1.00  6.95   A
ATOM   2161  CD  GLN A  63       5.456 -26.197  21.848  1.00  7.39   A
ATOM   2162  OE1 GLN A  63       5.840 -25.338  21.058  1.00  7.03   A
ATOM   2163  NE2 GLN A  63       4.702 -25.909  22.906  1.00  7.11   A
ATOM   2164  C   GLN A  63       6.108 -27.532  17.848  1.00  6.58   A
ATOM   2165  O   GLN A  63       6.976 -28.325  17.460  1.00  5.65   A
ATOM   2166  N   SER A  64       5.756 -26.451  17.163  1.00  7.01   A
ATOM   2167  CA  SER A  64       6.327 -26.156  15.858  1.00  7.60   A
ATOM   2168  CB  SER A  64       5.830 -24.788  15.369  1.00  7.93   A
ATOM   2169  OG  SER A  64       6.500 -23.724  16.016  1.00 10.49   A
ATOM   2170  C   SER A  64       7.853 -26.230  15.726  1.00  7.47   A
ATOM   2171  O   SER A  64       8.355 -26.838  14.778  1.00  8.15   A
ATOM   2172  N   LEU A  65       8.590 -25.625  16.659  1.00  7.41   A
ATOM   2173  CA  LEU A  65      10.057 -25.630  16.588  1.00  6.62   A
ATOM   2174  CB  LEU A  65      10.635 -24.537  17.507  1.00  6.26   A
ATOM   2175  CG  LEU A  65      10.102 -23.122  17.220  1.00  6.77   A
ATOM   2176  CD1 LEU A  65      10.889 -22.083  18.008  1.00  7.45   A
ATOM   2177  CD2 LEU A  65      10.218 -22.826  15.727  1.00  6.34   A
ATOM   2178  C   LEU A  65      10.650 -26.997  16.928  1.00  6.30   A
ATOM   2179  O   LEU A  65      11.690 -27.382  16.393  1.00  5.38   A
ATOM   2386  N   ASP A  93      15.188 -19.341  18.472  1.00  6.02   A
ATOM   2387  CA  ASP A  93      14.502 -18.945  19.704  1.00  6.44   A
ATOM   2388  CB  ASP A  93      15.115 -19.629  20.926  1.00  6.17   A
ATOM   2389  CG  ASP A  93      14.656 -21.070  21.084  1.00  6.96   A
ATOM   2390  OD1 ASP A  93      15.143 -21.748  22.016  1.00  8.03   A
ATOM   2391  OD2 ASP A  93      13.816 -21.527  20.286  1.00  7.18   A
ATOM   2392  C   ASP A  93      14.500 -17.427  19.910  1.00  6.65   A
ATOM   2393  O   ASP A  93      13.550 -16.869  20.470  1.00  6.96   A
ATOM   2394  N   THR A  94      15.558 -16.761  19.467  1.00  6.46   A
ATOM   2395  CA  THR A  94      15.605 -15.312  19.606  1.00  7.09   A
ATOM   2396  CB  THR A  94      16.967 -14.767  19.156  1.00  7.44   A
ATOM   2397  OG1 THR A  94      17.958 -15.187  20.105  1.00  8.81   A
ATOM   2398  CG2 THR A  94      16.960 -13.229  19.084  1.00  8.28   A
ATOM   2399  C   THR A  94      14.457 -14.732  18.760  1.00  6.91   A
ATOM   2400  O   THR A  94      13.724 -13.845  19.206  1.00  7.60   A
ATOM   2401  N   LEU A  95      14.271 -15.265  17.559  1.00  6.06   A
ATOM   2402  CA  LEU A  95      13.195 -14.795  16.687  1.00  6.05   A
ATOM   2403  CB  LEU A  95      13.322 -15.419  15.294  1.00  5.72   A
ATOM   2404  CG  LEU A  95      14.587 -15.000  14.533  1.00  6.19   A
ATOM   2405  CD1 LEU A  95      14.726 -15.828  13.269  1.00  5.14   A
ATOM   2406  CD2 LEU A  95      14.531 -13.509  14.208  1.00  6.20   A
ATOM   2407  C   LEU A  95      11.835 -15.144  17.289  1.00  6.40   A
ATOM   2408  O   LEU A  95      10.930 -14.310  17.332  1.00  6.49   A
ATOM   2409  N   ASP A  96      11.705 -16.367  17.788  1.00  6.39   A
ATOM   2410  CA  ASP A  96      10.448 -16.806  18.378  1.00  7.84   A
ATOM   2411  CB  ASP A  96      10.531 -18.280  18.762  1.00  7.75   A
ATOM   2412  CG  ASP A  96       9.190 -18.956  18.699  1.00  7.99   A
ATOM   2413  OD1 ASP A  96       8.526 -18.824  17.650  1.00  8.64   A
ATOM   2414  OD2 ASP A  96       8.805 -19.612  19.685  1.00  7.98   A
ATOM   2415  C   ASP A  96      10.059 -15.970  19.601  1.00  8.25   A
ATOM   2416  O   ASP A  96       8.886 -15.648  19.787  1.00  8.44   A
ATOM   2417  N   ASP A  97      11.049 -15.622  20.422  1.00  8.47   A
ATOM   2418  CA  ASP A  97      10.810 -14.799  21.601  1.00  9.21   A
ATOM   2419  CB  ASP A  97      12.129 -14.473  22.322  1.00  9.43   A
ATOM   2420  CG  ASP A  97      12.692 -15.652  23.121  1.00 10.37   A
ATOM   2421  OD1 ASP A  97      13.867 -15.570  23.540  1.00 10.72   A
ATOM   2422  OD2 ASP A  97      11.974 -16.651  23.342  1.00 11.19   A
ATOM   2423  C   ASP A  97      10.145 -13.487  21.161  1.00  9.58   A
ATOM   2424  O   ASP A  97       9.120 -13.097  21.709  1.00  9.77   A
ATOM   2425  N   PHE A  98      10.726 -12.812  20.172  1.00  9.72   A
ATOM   2426  CA  PHE A  98      10.162 -11.551  19.712  1.00  9.93   A
ATOM   2427  CB  PHE A  98      11.082 -10.888  18.683  1.00 10.00   A
ATOM   2428  CG  PHE A  98      10.641  -9.507  18.285  1.00 10.18   A
ATOM   2429  CD1 PHE A  98      10.605  -8.476  19.222  1.00 10.49   A
ATOM   2430  CD2 PHE A  98      10.236  -9.246  16.979  1.00 10.06   A
ATOM   2431  CE1 PHE A  98      10.164  -7.197  18.861  1.00 10.61   A
ATOM   2432  CE2 PHE A  98       9.798  -7.979  16.612  1.00 10.38   A
ATOM   2433  CZ  PHE A  98       9.762  -6.954  17.551  1.00 10.19   A
ATOM   2434  C   PHE A  98       8.754 -11.721  19.126  1.00 10.12   A
ATOM   2435  O   PHE A  98       7.838 -10.967  19.459  1.00  9.57   A
ATOM   2436  N   MET A  99       8.572 -12.723  18.273  1.00 10.66   A
ATOM   2437  CA  MET A  99       7.266 -12.956  17.675  1.00 11.35   A
ATOM   2438  CB  MET A  99       7.319 -14.137  16.697  1.00 11.47   A
ATOM   2439  CG  MET A  99       8.239 -13.935  15.491  1.00 11.14   A
ATOM   2440  SD  MET A  99       7.912 -12.430  14.557  1.00 11.29   A
ATOM   2441  CE  MET A  99       6.373 -12.849  13.740  1.00 10.00   A
ATOM   2442  C   MET A  99       6.198 -13.223  18.745  1.00 12.00   A
ATOM   2443  O   MET A  99       5.052 -12.804  18.596  1.00 12.28   A
ATOM   2444  N   SER A 100       6.562 -13.909  19.823  1.00 12.46   A
ATOM   2445  CA  SER A 100       5.579 -14.189  20.865  1.00 13.62   A
ATOM   2446  CB  SER A 100       6.092 -15.288  21.808  1.00 13.99   A
ATOM   2447  OG  SER A 100       6.241 -16.513  21.108  1.00 15.53   A
ATOM   2448  C   SER A 100       5.181 -12.942  21.666  1.00 13.94   A
ATOM   2449  O   SER A 100       4.196 -12.971  22.400  1.00 14.47   A
ATOM   2450  N   CYS A 101       5.935 -11.853  21.520  1.00 14.58   A
ATOM   2451  CA  CYS A 101       5.634 -10.596  22.222  1.00 15.68   A
ATOM   2452  CB  CYS A 101       6.759  -9.571  22.047  1.00 16.12   A
ATOM   2453  SG  CYS A 101       8.291  -9.874  22.933  1.00 20.40   A
ATOM   2454  C   CYS A 101       4.362  -9.950  21.693  1.00 15.48   A
ATOM   2455  O   CYS A 101       3.715  -9.184  22.404  1.00 15.75   A
ATOM   2456  N   PHE A 102       4.012 -10.245  20.445  1.00 15.64   A
ATOM   2457  CA  PHE A 102       2.825  -9.646  19.849  1.00 15.94   A
ATOM   2458  CB  PHE A 102       2.898  -9.712  18.321  1.00 14.57   A
ATOM   2459  CG  PHE A 102       4.035  -8.929  17.734  1.00 13.99   A
ATOM   2460  CD1 PHE A 102       5.336  -9.428  17.770  1.00 12.96   A
ATOM   2461  CD2 PHE A 102       3.812  -7.684  17.158  1.00 13.28   A
ATOM   2462  CE1 PHE A 102       6.393  -8.701  17.243  1.00 12.46   A
ATOM   2463  CE2 PHE A 102       4.865  -6.949  16.628  1.00 13.41   A
ATOM   2464  CZ  PHE A 102       6.159  -7.459  16.671  1.00 12.82   A
ATOM   2465  C   PHE A 102       1.529 -10.290  20.321  1.00 16.74   A
ATOM   2466  O   PHE A 102       1.422 -11.517  20.399  1.00 16.41   A
ATOM   2467  N   PRO A 103       0.523  -9.460  20.642  1.00 17.53   A
ATOM   2468  CD  PRO A 103       0.599  -7.989  20.671  1.00 17.55   A
ATOM   2469  CA  PRO A 103      -0.791  -9.916  21.112  1.00 18.81   A
ATOM   2470  CB  PRO A 103      -1.372  -8.658  21.748  1.00 18.35   A
ATOM   2471  CG  PRO A 103      -0.855  -7.591  20.841  1.00 17.64   A
ATOM   2472  C   PRO A 103      -1.646 -10.424  19.954  1.00 19.69   A
ATOM   2473  O   PRO A 103      -2.663  -9.827  19.613  1.00 20.09   A
ATOM   2474  N   TRP A 104      -1.221 -11.527  19.353  1.00 21.16   A
ATOM   2475  CA  TRP A 104      -1.925 -12.097  18.215  1.00 22.57   A
ATOM   2476  CB  TRP A 104      -1.215 -13.364  17.740  1.00 22.05   A
ATOM   2477  CG  TRP A 104       0.208 -13.135  17.325  1.00 22.03   A
ATOM   2478  CD2 TRP A 104       0.666 -12.577  16.085  1.00 22.05   A
ATOM   2479  CE2 TRP A 104       2.076 -12.530  16.144  1.00 22.03   A
ATOM   2480  CE3 TRP A 104       0.022 -12.110  14.931  1.00 21.92   A
ATOM   2481  CD1 TRP A 104       1.324 -13.393  18.060  1.00 21.72   A
ATOM   2482  NE1 TRP A 104       2.449 -13.036  17.360  1.00 21.99   A
ATOM   2483  CZ2 TRP A 104       2.856 -12.037  15.092  1.00 22.09   A
ATOM   2484  CZ3 TRP A 104       0.799 -11.618  13.883  1.00 22.10   A
ATOM   2485  CH2 TRP A 104       2.199 -11.587  13.973  1.00 22.21   A
ATOM   2486  C   TRP A 104      -3.398 -12.404  18.462  1.00 23.87   A
ATOM   2487  O   TRP A 104      -4.227 -12.208  17.580  1.00 23.92   A
ATOM   2488  N   ALA A 105      -3.725 -12.880  19.658  1.00 25.71   A
ATOM   2489  CA  ALA A 105      -5.110 -13.223  19.973  1.00 27.71   A
ATOM   2490  CB  ALA A 105      -5.161 -14.573  20.686  1.00 27.28   A
ATOM   2491  C   ALA A 105      -5.827 -12.168  20.814  1.00 28.94   A
ATOM   2492  O   ALA A 105      -6.594 -12.503  21.714  1.00 29.77   A
ATOM   2493  N   GLU A 106      -5.580 -10.897  20.527  1.00 30.28   A
ATOM   2494  CA  GLU A 106      -6.227  -9.825  21.272  1.00 31.40   A
ATOM   2495  CB  GLU A 106      -5.290  -8.622  21.389  1.00 31.69   A
ATOM   2496  CG  GLU A 106      -5.919  -7.415  22.061  1.00 32.04   A
ATOM   2497  CD  GLU A 106      -6.531  -7.755  23.407  1.00 32.68   A
ATOM   2498  OE1 GLU A 106      -5.780  -8.147  24.328  1.00 33.12   A
ATOM   2499  OE2 GLU A 106      -7.767  -7.636  23.540  1.00 32.39   A
ATOM   2500  C   GLU A 106      -7.529  -9.410  20.589  1.00 32.24   A
ATOM   2501  O   GLU A 106      -7.526  -8.979  19.433  1.00 31.93   A
ATOM   2502  N   LYS A 107      -8.640  -9.545  21.309  1.00 33.40   A
ATOM   2503  CA  LYS A 107      -9.951  -9.194  20.768  1.00 34.44   A
ATOM   2504  CB  LYS A 107     -11.064  -9.645  21.726  1.00 35.12   A
ATOM   2505  CG  LYS A 107     -11.028 -11.140  22.042  1.00 36.21   A
ATOM   2506  CD  LYS A 107     -12.355 -11.678  22.594  1.00 36.94   A
ATOM   2507  CE  LYS A 107     -12.840 -10.921  23.833  1.00 37.48   A
ATOM   2508  NZ  LYS A 107     -13.493  -9.618  23.499  1.00 37.90   A
ATOM   2509  C   LYS A 107     -10.082  -7.702  20.472  1.00 34.49   A
ATOM   2510  O   LYS A 107     -10.542  -7.319  19.396  1.00 34.58   A
ATOM   2511  N   LYS A 108      -9.683  -6.860  21.421  1.00 34.77   A
ATOM   2512  CA  LYS A 108      -9.755  -5.416  21.208  1.00 34.85   A
ATOM   2513  CB  LYS A 108      -9.397  -4.654  22.488  1.00 35.43   A
ATOM   2514  CG  LYS A 108     -10.511  -4.602  23.526  1.00 36.43   A
ATOM   2515  CD  LYS A 108     -10.639  -5.902  24.298  1.00 37.04   A
ATOM   2516  CE  LYS A 108      -9.476  -6.082  25.262  1.00 37.43   A
ATOM   2517  NZ  LYS A 108      -9.527  -7.411  25.947  1.00 37.89   A
ATOM   2518  C   LYS A 108      -8.796  -5.016  20.088  1.00 34.70   A
ATOM   2519  O   LYS A 108      -7.578  -5.103  20.239  1.00 34.50   A
ATOM   2520  N   GLN A 109      -9.359  -4.575  18.968  1.00 34.41   A
ATOM   2521  CA  GLN A 109      -8.575  -4.174  17.806  1.00 34.31   A
ATOM   2522  CB  GLN A 109      -9.511  -3.809  16.651  1.00 35.11   A
ATOM   2523  CG  GLN A 109      -8.806  -3.584  15.327  1.00 36.38   A
ATOM   2524  CD  GLN A 109      -8.007  -4.800  14.893  1.00 37.34   A
ATOM   2525  OE1 GLN A 109      -8.525  -5.922  14.858  1.00 37.88   A
ATOM   2526  NE2 GLN A 109      -6.737  -4.586  14.560  1.00 37.71   A
ATOM   2527  C   GLN A 109      -7.632  -3.006  18.082  1.00 33.82   A
ATOM   2528  O   GLN A 109      -6.437  -3.086  17.802  1.00 33.77   A
ATOM   2529  N   ASP A 110      -8.178  -1.921  18.621  1.00 33.24   A
ATOM   2530  CA  ASP A 110      -7.393  -0.731  18.926  1.00 32.17   A
ATOM   2531  CB  ASP A 110      -8.290   0.339  19.561  1.00 33.29   A
ATOM   2532  CG  ASP A 110      -9.147  -0.208  20.689  1.00 34.12   A
ATOM   2533  OD1 ASP A 110      -8.607  -0.469  21.785  1.00 34.82   A
ATOM   2534  OD2 ASP A 110     -10.365  -0.383  20.474  1.00 35.05   A
ATOM   2535  C   ASP A 110      -6.217  -1.045  19.845  1.00 30.99   A
ATOM   2536  O   ASP A 110      -5.103  -0.561  19.626  1.00 30.41   A
ATOM   2537  N   VAL A 111      -6.469  -1.852  20.870  1.00 29.43   A
ATOM   2538  CA  VAL A 111      -5.430  -2.236  21.815  1.00 28.27   A
ATOM   2539  CB  VAL A 111      -6.010  -3.086  22.964  1.00 28.68   A
ATOM   2540  CG1 VAL A 111      -4.891  -3.532  23.899  1.00 28.43   A
ATOM   2541  CG2 VAL A 111      -7.061  -2.285  23.718  1.00 28.82   A
ATOM   2542  C   VAL A 111      -4.373  -3.061  21.089  1.00 27.11   A
ATOM   2543  O   VAL A 111      -3.176  -2.848  21.258  1.00 26.42   A
ATOM   2544  N   LYS A 112      -4.832  -4.005  20.276  1.00 26.09   A
ATOM   2545  CA  LYS A 112      -3.936  -4.866  19.518  1.00 25.03   A
ATOM   2546  CB  LYS A 112      -4.754  -5.880  18.717  1.00 25.17   A
ATOM   2547  CG  LYS A 112      -3.932  -6.879  17.927  1.00 25.45   A
ATOM   2548  CD  LYS A 112      -4.832  -7.932  17.297  1.00 25.91   A
ATOM   2549  CE  LYS A 112      -4.021  -8.973  16.535  1.00 26.40   A
ATOM   2550  NZ  LYS A 112      -4.889 -10.025  15.934  1.00 26.69   A
ATOM   2551  C   LYS A 112      -3.055  -4.044  18.580  1.00 24.09   A
ATOM   2552  O   LYS A 112      -1.832  -4.200  18.567  1.00 23.73   A
ATOM   2553  N   GLU A 113      -3.685  -3.161  17.810  1.00 22.88   A
ATOM   2554  CA  GLU A 113      -2.980  -2.314  16.853  1.00 22.08   A
ATOM   2555  CB  GLU A 113      -3.993  -1.498  16.036  1.00 23.03   A
ATOM   2556  CG  GLU A 113      -3.394  -0.676  14.915  1.00 24.94   A
ATOM   2557  CD  GLU A 113      -4.453  -0.101  13.976  1.00 26.15   A
ATOM   2558  OE1 GLU A 113      -5.181  -0.894  13.332  1.00 26.50   A
ATOM   2559  OE2 GLU A 113      -4.556   1.142  13.881  1.00 27.05   A
ATOM   2560  C   GLU A 113      -1.973  -1.383  17.532  1.00 20.78   A
ATOM   2561  O   GLU A 113      -0.874  -1.162  17.022  1.00 19.80   A
ATOM   2562  N   GLN A 114      -2.345  -0.839  18.684  1.00 19.79   A
ATOM   2563  CA  GLN A 114      -1.450   0.047  19.406  1.00 19.27   A
ATOM   2564  CB  GLN A 114      -2.154   0.632  20.634  1.00 20.01   A
ATOM   2565  CG  GLN A 114      -1.301   1.615  21.423  1.00 21.19   A
ATOM   2566  CD  GLN A 114      -0.997   2.890  20.650  1.00 22.15   A
ATOM   2567  OE1 GLN A 114      -0.144   3.681  21.059  1.00 23.10   A
ATOM   2568  NE2 GLN A 114      -1.699   3.102  19.536  1.00 21.70   A
ATOM   2569  C   GLN A 114      -0.188  -0.709  19.838  1.00 18.22   A
ATOM   2570  O   GLN A 114       0.927  -0.242  19.604  1.00 17.80   A
ATOM   2571  N   MET A 115      -0.365  -1.877  20.452  1.00 17.56   A
ATOM   2572  CA  MET A 115       0.769  -2.676  20.908  1.00 17.24   A
ATOM   2573  CB  MET A 115       0.290  -3.905  21.693  1.00 19.31   A
ATOM   2574  CG  MET A 115       1.431  -4.735  22.269  1.00 21.86   A
ATOM   2575  SD  MET A 115       0.923  -5.795  23.655  1.00 26.35   A
ATOM   2576  CE  MET A 115       0.941  -4.589  25.027  1.00 25.28   A
ATOM   2577  C   MET A 115       1.655  -3.122  19.744  1.00 15.84   A
ATOM   2578  O   MET A 115       2.882  -3.125  19.860  1.00 15.55   A
ATOM   2579  N   PHE A 116       1.035  -3.509  18.632  1.00 14.07   A
ATOM   2580  CA  PHE A 116       1.786  -3.928  17.452  1.00 13.26   A
ATOM   2581  CB  PHE A 116       0.845  -4.301  16.300  1.00 12.53   A
ATOM   2582  CG  PHE A 116       0.588  -5.775  16.176  1.00 12.20   A
ATOM   2583  CD1 PHE A 116      -0.130  -6.453  17.154  1.00 12.43   A
ATOM   2584  CD2 PHE A 116       1.076  -6.489  15.089  1.00 12.72   A
ATOM   2585  CE1 PHE A 116      -0.360  -7.817  17.052  1.00 12.44   A
ATOM   2586  CE2 PHE A 116       0.851  -7.864  14.974  1.00 12.31   A
ATOM   2587  CZ  PHE A 116       0.131  -8.526  15.960  1.00 12.74   A
ATOM   2588  C   PHE A 116       2.677  -2.775  17.002  1.00 12.47   A
ATOM   2589  O   PHE A 116       3.870  -2.948  16.773  1.00 12.52   A
ATOM   2876  N   TYR A 152      13.612 -19.507   9.014  1.00  7.45   A
ATOM   2877  CA  TYR A 152      12.780 -18.882  10.032  1.00  7.80   A
ATOM   2878  CB  TYR A 152      13.127 -19.416  11.419  1.00  7.71   A
ATOM   2879  CG  TYR A 152      11.963 -19.316  12.386  1.00  8.94   A
ATOM   2880  CD1 TYR A 152      10.717 -19.858  12.063  1.00  9.56   A
ATOM   2881  CE1 TYR A 152       9.649 -19.802  12.961  1.00  9.81   A
ATOM   2882  CD2 TYR A 152      12.110 -18.706  13.630  1.00  9.51   A
ATOM   2883  CE2 TYR A 152      11.050 -18.642  14.534  1.00  9.37   A
ATOM   2884  CZ  TYR A 152       9.828 -19.197  14.191  1.00 10.01   A
ATOM   2885  OH  TYR A 152       8.787 -19.193  15.101  1.00 10.22   A
ATOM   2886  C   TYR A 152      12.871 -17.368  10.032  1.00  7.80   A
ATOM   2887  O   TYR A 152      11.906 -16.685  10.363  1.00  7.64   A
ATOM   2888  N   TRP A 153      14.037 -16.848   9.671  1.00  7.83   A
ATOM   2889  CA  TRP A 153      14.217 -15.409   9.615  1.00  8.29   A
ATOM   2890  CB  TRP A 153      15.675 -15.058   9.323  1.00  8.19   A
ATOM   2891  CG  TRP A 153      15.826 -13.715   8.694  1.00  8.54   A
ATOM   2892  CD2 TRP A 153      15.414 -12.464   9.247  1.00  8.88   A
ATOM   2893  CE2 TRP A 153      15.716 -11.467   8.299  1.00  8.91   A
ATOM   2894  CE3 TRP A 153      14.816 -12.087  10.458  1.00  9.75   A
ATOM   2895  CD1 TRP A 153      16.348 -13.438   7.466  1.00  8.71   A
ATOM   2896  NE1 TRP A 153      16.285 -12.087   7.219  1.00  9.04   A
ATOM   2897  CZ2 TRP A 153      15.440 -10.111   8.519  1.00  9.95   A
ATOM   2898  CZ3 TRP A 153      14.541 -10.734  10.676  1.00  9.92   A
ATOM   2899  CH2 TRP A 153      14.855  -9.766   9.708  1.00  9.14   A
ATOM   2900  C   TRP A 153      13.336 -14.871   8.493  1.00  8.23   A
ATOM   2901  O   TRP A 153      12.676 -13.852   8.647  1.00  8.77   A
ATOM   2902  N   GLU A 154      13.336 -15.572   7.364  1.00  8.71   A
ATOM   2903  CA  GLU A 154      12.547 -15.159   6.204  1.00  8.50   A
ATOM   2904  CB  GLU A 154      12.862 -16.034   4.995  1.00  8.57   A
ATOM   2905  CG  GLU A 154      12.336 -15.455   3.679  1.00  9.53   A
ATOM   2906  CD  GLU A 154      10.920 -15.883   3.350  1.00  8.58   A
ATOM   2907  OE1 GLU A 154      10.337 -15.318   2.400  1.00  9.21   A
ATOM   2908  OE2 GLU A 154      10.397 -16.785   4.019  1.00  8.79   A
ATOM   2909  C   GLU A 154      11.064 -15.205   6.496  1.00  8.22   A
ATOM   2910  O   GLU A 154      10.310 -14.309   6.102  1.00  8.84   A
ATOM   2911  N   ILE A 155      10.650 -16.258   7.191  1.00  7.89   A
ATOM   2912  CA  ILE A 155       9.254 -16.444   7.547  1.00  6.85   A
ATOM   2913  CB  ILE A 155       9.041 -17.887   8.105  1.00  7.23   A
ATOM   2914  CG2 ILE A 155       7.742 -17.975   8.898  1.00  6.59   A
ATOM   2915  CG1 ILE A 155       9.067 -18.893   6.939  1.00  7.31   A
ATOM   2916  CD1 ILE A 155       9.155 -20.382   7.343  1.00  5.54   A
ATOM   2917  C   ILE A 155       8.816 -15.378   8.568  1.00  7.33   A
ATOM   2918  O   ILE A 155       7.801 -14.702   8.375  1.00  6.57   A
ATOM   2919  N   CYS A 156       9.601 -15.196   9.628  1.00  7.49   A
ATOM   2920  CA  CYS A 156       9.245 -14.209  10.638  1.00  7.46   A
ATOM   2921  CB  CYS A 156      10.227 -14.252  11.818  1.00  7.91   A
ATOM   2922  SG  CYS A 156      10.226 -15.769  12.755  1.00  8.41   A
ATOM   2923  C   CYS A 156       9.230 -12.799  10.029  1.00  7.56   A
ATOM   2924  O   CYS A 156       8.238 -12.075  10.148  1.00  7.15   A
ATOM   2925  N   SER A 157      10.296 -12.427   9.319  1.00  7.31   A
ATOM   2926  CA  SER A 157      10.345 -11.095   8.733  1.00  7.15   A
ATOM   2927  CB  SER A 157      11.739 -10.802   8.137  1.00  6.90   A
ATOM   2928  OG  SER A 157      12.045 -11.626   7.027  1.00  5.72   A
ATOM   2929  C   SER A 157       9.226 -10.893   7.706  1.00  7.42   A
ATOM   2930  O   SER A 157       8.700  -9.793   7.591  1.00  7.72   A
ATOM   2931  N   THR A 158       8.831 -11.938   6.980  1.00  7.58   A
ATOM   2932  CA  THR A 158       7.744 -11.762   6.012  1.00  8.17   A
ATOM   2933  CB  THR A 158       7.434 -13.070   5.248  1.00  8.62   A
ATOM   2934  OG1 THR A 158       8.325 -13.172   4.128  1.00  9.05   A
ATOM   2935  CG2 THR A 158       5.989 -13.090   4.742  1.00  8.43   A
ATOM   2936  C   THR A 158       6.491 -11.257   6.733  1.00  8.44   A
ATOM   2937  O   THR A 158       5.843 -10.317   6.278  1.00  7.98   A
ATOM   2938  N   THR A 159       6.178 -11.848   7.881  1.00  8.66   A
ATOM   2939  CA  THR A 159       5.008 -11.421   8.630  1.00  9.74   A
ATOM   2940  CB  THR A 159       4.661 -12.441   9.728  1.00 11.00   A
ATOM   2941  OG1 THR A 159       4.147 -13.633   9.113  1.00 11.94   A
ATOM   2942  CG2 THR A 159       3.603 -11.874  10.663  1.00 11.12   A
ATOM   2943  C   THR A 159       5.136 -10.016   9.248  1.00  9.29   A
ATOM   2944  O   THR A 159       4.201  -9.222   9.163  1.00  9.32   A
ATOM   2945  N   LEU A 160       6.287  -9.707   9.850  1.00  9.10   A
ATOM   2946  CA  LEU A 160       6.509  -8.394  10.464  1.00  8.76   A
ATOM   2947  CB  LEU A 160       7.887  -8.342  11.143  1.00  8.08   A
ATOM   2948  CG  LEU A 160       8.152  -9.296  12.318  1.00  8.40   A
ATOM   2949  CD1 LEU A 160       9.616  -9.250  12.706  1.00  7.66   A
ATOM   2950  CD2 LEU A 160       7.259  -8.925  13.491  1.00  7.69   A
ATOM   2951  C   LEU A 160       6.424  -7.279   9.417  1.00  8.80   A
ATOM   2952  O   LEU A 160       5.912  -6.192   9.691  1.00  8.81   A
ATOM   2953  N   LEU A 161       6.946  -7.553   8.226  1.00  9.13   A
ATOM   2954  CA  LEU A 161       6.921  -6.586   7.131  1.00  9.84   A
ATOM   2955  CB  LEU A 161       7.637  -7.159   5.905  1.00  9.15   A
ATOM   2956  CG  LEU A 161       9.144  -6.881   5.882  1.00  9.55   A
ATOM   2957  CD1 LEU A 161       9.822  -7.612   4.700  1.00  9.05   A
ATOM   2958  CD2 LEU A 161       9.351  -5.388   5.757  1.00  8.83   A
ATOM   2959  C   LEU A 161       5.495  -6.184   6.768  1.00 10.43   A
ATOM   2960  O   LEU A 161       5.262  -5.090   6.249  1.00 10.78   A
ATOM   2961  N   VAL A 162       4.542  -7.068   7.055  1.00 10.57   A
ATOM   2962  CA  VAL A 162       3.137  -6.794   6.776  1.00 11.31   A
ATOM   2963  CB  VAL A 162       2.244  -8.045   7.041  1.00 11.09   A
ATOM   2964  CG1 VAL A 162       0.770  -7.682   6.916  1.00 12.11   A
ATOM   2965  CG2 VAL A 162       2.585  -9.147   6.047  1.00 11.31   A
ATOM   2966  C   VAL A 162       2.660  -5.648   7.662  1.00 11.94   A
ATOM   2967  O   VAL A 162       1.909  -4.789   7.214  1.00 12.85   A
ATOM   2968  N   PHE A 163       3.104  -5.622   8.916  1.00 12.19   A
ATOM   2969  CA  PHE A 163       2.681  -4.561   9.825  1.00 12.54   A
ATOM   2970  CB  PHE A 163       2.500  -5.112  11.239  1.00 13.07   A
ATOM   2971  CG  PHE A 163       1.527  -6.248  11.321  1.00 14.49   A
ATOM   2972  CD1 PHE A 163       1.959  -7.555  11.156  1.00 14.30   A
ATOM   2973  CD2 PHE A 163       0.168  -6.007  11.532  1.00 14.47   A
ATOM   2974  CE1 PHE A 163       1.058  -8.618  11.197  1.00 15.26   A
ATOM   2975  CE2 PHE A 163      -0.743  -7.061  11.574  1.00 15.43   A
ATOM   2976  CZ  PHE A 163      -0.297  -8.371  11.406  1.00 14.83   A
ATOM   2977  C   PHE A 163       3.625  -3.362   9.868  1.00 12.48   A
ATOM   2978  O   PHE A 163       3.233  -2.280  10.305  1.00 12.19   A
ATOM   3252  N   THR A 197      -2.372 -16.130   2.207  1.00  8.89   A
ATOM   3253  CA  THR A 197      -3.090 -15.716   3.399  1.00  9.12   A
ATOM   3254  CB  THR A 197      -3.159 -16.854   4.438  1.00  8.54   A
ATOM   3255  OG1 THR A 197      -1.826 -17.241   4.803  1.00  7.22   A
ATOM   3256  CG2 THR A 197      -3.891 -18.055   3.859  1.00  8.20   A
ATOM   3257  C   THR A 197      -2.349 -14.557   4.045  1.00 10.07   A
ATOM   3258  O   THR A 197      -1.153 -14.380   3.829  1.00  9.98   A
ATOM   3259  N   LYS A 198      -3.063 -13.756   4.821  1.00 11.83   A
ATOM   3260  CA  LYS A 198      -2.431 -12.648   5.525  1.00 14.16   A
ATOM   3261  CB  LYS A 198      -3.407 -11.497   5.746  1.00 14.77   A
ATOM   3262  CG  LYS A 198      -2.803 -10.367   6.571  1.00 16.50   A
ATOM   3263  CD  LYS A 198      -3.868  -9.483   7.196  1.00 17.64   A
ATOM   3264  CE  LYS A 198      -3.217  -8.361   8.008  1.00 18.15   A
ATOM   3265  NZ  LYS A 198      -4.215  -7.462   8.646  1.00 18.92   A
ATOM   3266  C   LYS A 198      -2.042 -13.213   6.882  1.00 15.13   A
ATOM   3267  O   LYS A 198      -2.869 -13.236   7.788  1.00 17.31   A
ATOM   3268  N   LEU A 199      -0.803 -13.670   7.005  1.00 14.65   A
ATOM   3269  CA  LEU A 199      -0.257 -14.254   8.234  1.00 13.81   A
ATOM   3270  CB  LEU A 199      -1.137 -13.966   9.468  1.00 15.00   A
ATOM   3271  CG  LEU A 199      -1.354 -12.517   9.953  1.00 15.52   A
ATOM   3272  CD1 LEU A 199      -2.352 -12.514  11.110  1.00 15.65   A
ATOM   3273  CD2 LEU A 199      -0.032 -11.901  10.400  1.00 16.55   A
ATOM   3274  C   LEU A 199      -0.078 -15.770   8.070  1.00 13.40   A
ATOM   3275  O   LEU A 199       0.673 -16.360   8.862  1.00 12.28   A
ATOM   3276  OXT LEU A 199      -0.695 -16.347   7.147  1.00 12.25   A
ATOM   6573  N1  GSH F 200       4.240 -22.620  20.817  1.00 44.60   F
ATOM   6574  CA1 GSH F 200       3.413 -23.575  20.073  1.00 44.99   F
ATOM   6575  C1  GSH F 200       4.146 -24.142  18.822  1.00 44.16   F
ATOM   6576  O11 GSH F 200       5.277 -23.724  18.545  1.00 44.01   F
ATOM   6577  O12 GSH F 200       3.502 -25.050  18.113  1.00 43.49   F
ATOM   6578  CB1 GSH F 200       2.101 -22.895  19.661  1.00 45.74   F
ATOM   6579  CG1 GSH F 200       1.180 -22.538  20.853  1.00 46.69   F
ATOM   6580  CD1 GSH F 200       0.010 -21.712  20.254  1.00 47.11   F
ATOM   6581  OE1 GSH F 200      -0.142 -20.530  20.586  1.00 47.97   F
ATOM   6582  N2  GSH F 200      -0.754 -22.340  19.334  1.00 47.00   F
ATOM   6583  CA2 GSH F 200      -1.817 -21.594  18.641  1.00 46.63   F
ATOM   6584  C2  GSH F 200      -3.172 -22.214  18.985  1.00 46.78   F
ATOM   6585  O2  GSH F 200      -3.381 -23.428  18.891  1.00 46.26   F
ATOM   6586  CB2 GSH F 200      -1.659 -21.704  17.108  1.00 46.61   F
ATOM   6587  SG2 GSH F 200      -0.726 -20.334  16.354  1.00 45.55   F
ATOM   6588  N3  GSH F 200      -4.138 -21.341  19.347  1.00 47.03   F
ATOM   6589  CA3 GSH F 200      -5.549 -21.727  19.555  1.00 47.63   F
ATOM   6590  C3  GSH F 200      -5.805 -21.983  21.029  1.00 47.96   F
ATOM   6591  O31 GSH F 200      -6.963 -22.325  21.339  1.00 48.33   F
ATOM   6592  O32 GSH F 200      -4.849 -21.855  21.833  1.00 48.13   F
ATOM   6684  C1  CBD V 201       1.320 -16.944  18.446  1.00 55.65   V
ATOM   6685  SA  CBD V 201       0.790 -17.122  20.115  1.00 56.02   V
ATOM   6686  O1A CBD V 201       1.575 -18.205  20.799  1.00 55.76   V
ATOM   6687  O2A CBD V 201      -0.636 -17.464  19.966  1.00 55.91   V
ATOM   6688  O3A CBD V 201       1.221 -15.829  20.717  1.00 55.92   V
ATOM   6689  C2  CBD V 201       2.711 -17.027  18.129  1.00 55.38   V
ATOM   6690  N2  CBD V 201       3.702 -17.265  19.274  1.00 55.19   V
ATOM   6691  C3  CBD V 201       3.112 -16.894  16.760  1.00 55.20   V
ATOM   6692  C4  CBD V 201       4.532 -16.974  16.323  1.00 54.93   V
ATOM   6693  O4  CBD V 201       5.374 -17.167  17.212  1.00 55.39   V
ATOM   6694  C5  CBD V 201       5.017 -16.849  14.925  1.00 54.45   V
ATOM   6695  C6  CBD V 201       6.495 -16.945  14.509  1.00 54.14   V
ATOM   6696  C7  CBD V 201       6.812 -16.806  13.140  1.00 53.94   V
ATOM   6697  C8  CBD V 201       5.803 -16.585  12.172  1.00 53.98   V
ATOM   6698  C9  CBD V 201       4.432 -16.493  12.529  1.00 54.22   V
ATOM   6699  C10 CBD V 201       4.023 -16.624  13.897  1.00 54.48   V
ATOM   6700  C11 CBD V 201       2.621 -16.543  14.333  1.00 54.89   V
ATOM   6701  O11 CBD V 201       1.771 -16.353  13.468  1.00 54.55   V
ATOM   6702  C12 CBD V 201       2.094 -16.666  15.725  1.00 55.45   V
ATOM   6703  C13 CBD V 201       0.676 -16.584  16.095  1.00 56.18   V
ATOM   6704  C14 CBD V 201       0.298 -16.725  17.474  1.00 55.98   V
ATOM   6705  NB  CBD V 201      -0.387 -16.360  15.063  1.00 57.55   V
ATOM   6706  CB1 CBD V 201      -4.096 -17.069  15.898  1.00 61.45   V
ATOM   6707  SB  CBD V 201      -5.117 -18.384  16.588  1.00 62.03   V
ATOM   6708  O1B CBD V 201      -5.591 -17.837  17.918  1.00 62.06   V
ATOM   6709  O2B CBD V 201      -4.217 -19.550  16.781  1.00 62.13   V
ATOM   6710  O3B CBD V 201      -6.221 -18.727  15.629  1.00 61.84   V
ATOM   6711  CB2 CBD V 201      -4.648 -15.806  15.457  1.00 61.61   V
ATOM   6712  CB3 CBD V 201      -3.798 -14.783  14.909  1.00 60.85   V
ATOM   6713  CB4 CBD V 201      -2.415 -14.973  14.785  1.00 59.79   V
ATOM   6714  CB5 CBD V 201      -1.838 -16.208  15.214  1.00 59.24   V
ATOM   6715  CB6 CBD V 201      -2.667 -17.266  15.769  1.00 60.28   V
ATOM   6716  NC  CBD V 201      -6.100 -15.699  15.626  1.00 62.61   V
ATOM   6717  NC1 CBD V 201      -7.272 -13.869  16.843  1.00 64.01   V
ATOM   6718  CC2 CBD V 201      -7.958 -12.677  16.830  1.00 64.30   V
ATOM   6719  XCL CBD V 201      -8.536 -11.955  18.433  1.00 64.97   V
ATOM   6720  NC3 CBD V 201      -8.179 -12.086  15.587  1.00 64.60   V
ATOM   6721  CC4 CBD V 201      -7.742 -12.647  14.411  1.00 64.72   V
ATOM   6722  NC5 CBD V 201      -7.067 -13.826  14.459  1.00 64.27   V
ATOM   6723  CC6 CBD V 201      -6.835 -14.427  15.666  1.00 63.60   V
ATOM   6724  ND  CBD V 201      -7.999 -11.990  13.118  1.00 65.16   V
ATOM   6725  CD1 CBD V 201      -6.460 -11.914  11.166  1.00 65.80   V
ATOM   6726  SD  CBD V 201      -5.663 -10.543  12.000  1.00 66.14   V
ATOM   6727  O1D CBD V 201      -4.963 -11.035  13.249  1.00 66.20   V
ATOM   6728  O2D CBD V 201      -6.740  -9.533  12.229  1.00 66.14   V
ATOM   6729  O3D CBD V 201      -4.469  -9.967  11.283  1.00 66.06   V
ATOM   6730  CD2 CBD V 201      -7.612 -12.553  11.819  1.00 65.58   V
ATOM   6731  CD3 CBD V 201      -8.282 -13.667  11.168  1.00 65.50   V
ATOM   6732  CD4 CBD V 201      -7.820 -14.138   9.898  1.00 65.62   V
ATOM   6733  CD5 CBD V 201      -6.689 -13.516   9.253  1.00 65.58   V
ATOM   6734  CD6 CBD V 201      -6.009 -12.418   9.867  1.00 65.66   V
ATOM   6736 CA+2 CA2 M 902      10.668 -20.783  23.896  1.00 51.04   M
ATOM   6737  OH2 WAT S   1       1.351 -21.691   3.667  1.00  7.98   S
ATOM   6739  OH2 WAT S   3      -1.239 -27.422   7.740  1.00  3.33   S
ATOM   6740  OH2 WAT S   4       8.134 -25.070  19.531  1.00  9.51   S
ATOM   6743  OH2 WAT S   7       6.599 -20.828  11.162  1.00  4.11   S
ATOM   6747  OH2 WAT S  11       5.286 -16.048   7.235  1.00  3.73   S
ATOM   6751  OH2 WAT S  15       6.780 -21.479  14.227  1.00  6.02   S
ATOM   6758  OH2 WAT S  22       0.702 -16.833   2.360  1.00  8.75   S
ATOM   6760  OH2 WAT S  24       7.629 -15.477   2.582  1.00  9.74   S
ATOM   6761  OH2 WAT S  25      -2.129 -33.873  12.001  1.00  6.94   S
ATOM   6772  OH2 WAT S  36       0.027 -13.756   1.035  1.00 15.53   S
ATOM   6773  OH2 WAT S  37       2.414 -15.170  10.370  1.00 10.38   S
ATOM   6777  OH2 WAT S  42       9.861 -20.611  21.788  1.00 19.36   S
ATOM   6782  OH2 WAT S  47      -0.738 -19.696   3.763  1.00  7.26   S
ATOM   6786  OH2 WAT S  51      -8.079 -21.562   9.291  1.00 11.54   S
ATOM   6798  OH2 WAT S  63      11.971 -27.063  20.805  1.00 13.89   S
ATOM   6799  OH2 WAT S  64      -6.746 -29.289   4.136  1.00 17.17   S
ATOM   6806  OH2 WAT S  71       2.082 -27.303  18.951  1.00  6.50   S
ATOM   6808  OH2 WAT S  73       6.370 -34.029  20.049  1.00  7.66   S
ATOM   6833  OH2 WAT S  98      -0.925 -29.526  21.487  1.00  8.88   S
ATOM   6873  OH2 WAT S 138      12.612 -27.001  23.449  1.00 21.34   S
ATOM   6881  OH2 WAT S 146       1.862 -24.047  27.300  1.00 13.69   S
ATOM   6900  OH2 WAT S 165       8.353 -19.515  24.914  1.00 21.77   S
ATOM   6940  OH2 WAT S 205      -5.859 -14.566   5.222  1.00 13.11   S
ATOM   6972  OH2 WAT S 237      -2.575 -19.558  21.111  1.00 44.73   S
ATOM   6992  OH2 WAT S 257      -8.895 -24.364   5.325  1.00 26.95   S
ATOM   6996  OH2 WAT S 261       4.413 -17.589  25.511  1.00 30.40   S
ATOM   7000  OH2 WAT S 265      -5.639 -28.605  26.537  1.00 35.00   S
ATOM   7015  OH2 WAT S 280      -6.647 -16.720   1.613  1.00 29.73   S
ATOM   7031  OH2 WAT S 296      13.593 -19.947  25.168  1.00 25.03   S
ATOM   7053  OH2 WAT S 318       6.658 -19.330  21.220  1.00 29.42   S
ATOM   7057  OH2 WAT S 322       7.702 -22.083  20.657  1.00 26.23   S
ATOM   7060  OH2 WAT S 325      13.812 -24.922  22.589  1.00 25.62   S
ATOM   7066  OH2 WAT S 331      -3.023 -35.741  20.966  1.00 51.90   S
ATOM   7071  OH2 WAT S 336       8.646 -22.439  23.070  1.00 32.36   S
ATOM   7117  OH2 WAT S 383      -7.864 -19.607  18.001  1.00 49.01   S
ATOM   7119  OH2 WAT S 385      12.122 -19.312  22.304  1.00 36.04   S
ATOM   7149  OH2 WAT S 415       4.500 -17.354   9.500  1.00 17.11   S
ATOM   7151  OH2 WAT S 417       3.003 -10.979   2.789  1.00  8.57   S
ATOM   7161  OH2 WAT S 427       1.666 -28.319  21.869  1.00  9.23   S
ATOM   7173  OH2 WAT S 439       1.707 -26.590  23.994  1.00 20.49   S
ATOM   7175  OH2 WAT S 441      -7.142 -12.553   6.181  1.00 27.77   S
ATOM   7217  OH2 WAT S 483      -1.287 -25.245  26.731  1.00 38.16   S
ATOM   7239  OH2 WAT S 505       8.962 -18.324  22.747  1.00 40.69   S
ATOM   7269  OH2 WAT S 535      -8.231 -19.382  10.779  1.00 39.27   S
ATOM   7291  OH2 WAT S 557      -7.790 -15.423   3.534  1.00 48.88   S
ATOM   7294  OH2 WAT S 560      -6.131 -17.042   6.655  1.00 28.01   S
ATOM   7305  OH2 WAT S 571      -5.344 -20.658  29.405  1.00 33.64   S
ATOM   7319  OH2 WAT S 585      -8.529 -10.641  23.648  1.00 36.23   S
ATOM   7335  OH2 WAT S 601      13.245 -24.342  20.045  1.00 20.43   S
ATOM   7341  OH2 WAT S 607      15.091 -23.061  18.509  1.00 28.00   S
ATOM   7342  OH2 WAT S 608       2.114 -23.889  24.521  1.00 24.13   S
ATOM   7354  OH2 WAT S 620      -5.822 -33.782  12.796  1.00 39.40   S
ATOM   7412  OH2 WAT S 679      -4.210 -15.053   7.903  1.00  7.85   S
ATOM   7416  OH2 WAT S 683     -11.812 -20.860  17.588  1.00 35.78   S
ATOM   7418  OH2 WAT S 685      -5.319 -36.445  17.400  1.00 36.65   S
ATOM   7432  OH2 WAT S 701       0.414 -10.954   3.856  1.00  3.57   S
ATOM   7433  OH2 WAT S 702       3.171 -13.470   2.015  1.00 31.21   S
ATOM   7518  OH2 WAT S 792      -6.880 -19.345   1.064  1.00 28.83   S
ATOM   7544  OH2 WAT S 818     -14.589 -21.459  10.093  1.00 28.52   S
ATOM   7546  OH2 WAT S 820     -15.291 -27.899  16.026  1.00 38.45   S
ATOM   7576  OH2 WAT S 850       4.135 -19.875  21.107  1.00 51.02   S
ATOM   7581  OH2 WAT S 855       5.075 -11.173  29.078  1.00 44.63   S
ATOM   7582  OH2 WAT S 856      -1.969 -27.093  28.386  1.00 36.21   S
ATOM   7590  OH2 WAT S 864       1.742  -9.916  24.316  1.00 49.81   S
ATOM   7591  OH2 WAT S 865       6.598 -16.698   4.969  1.00 27.41   S
【００５４】
【表８】
ヒト由来造血器型ＰＧＤＳマグネシウム型と、グルタチオン及び４−ベンズヒドリルオキシ−１−{３−（１Ｈ−テトラゾール−５−イル）−プロピル}ピペリジンとの複合体の３次元構造座標
ATOM   4966  N   TYR A   8      17.463  -2.741  10.967  1.00  2.30   A
ATOM   4967  CA  TYR A   8      16.069  -2.648  11.384  1.00  2.27   A
ATOM   4968  CB  TYR A   8      15.463  -1.311  10.947  1.00  1.93   A
ATOM   4969  CG  TYR A   8      14.123  -1.007  11.579  1.00  1.75   A
ATOM   4970  CD1 TYR A   8      13.996  -0.888  12.962  1.00  1.76   A
ATOM   4971  CE1 TYR A   8      12.771  -0.568  13.551  1.00  1.82   A
ATOM   4972  CD2 TYR A   8      12.987  -0.803  10.792  1.00  1.81   A
ATOM   4973  CE2 TYR A   8      11.762  -0.479  11.366  1.00  2.19   A
ATOM   4974  CZ  TYR A   8      11.658  -0.360  12.748  1.00  1.84   A
ATOM   4975  OH  TYR A   8      10.456  -0.003  13.318  1.00  2.39   A
ATOM   4976  C   TYR A   8      15.320  -3.786  10.709  1.00  2.74   A
ATOM   4977  O   TYR A   8      15.902  -4.543   9.939  1.00  2.59   A
ATOM   4978  N   PHE A   9      14.033  -3.916  11.011  1.00  3.54   A
ATOM   4979  CA  PHE A   9      13.216  -4.945  10.378  1.00  4.12   A
ATOM   4980  CB  PHE A   9      11.873  -5.079  11.102  1.00  4.53   A
ATOM   4981  CG  PHE A   9      11.981  -5.579  12.511  1.00  4.71   A
ATOM   4982  CD1 PHE A   9      11.552  -4.791  13.577  1.00  5.32   A
ATOM   4983  CD2 PHE A   9      12.499  -6.844  12.777  1.00  5.02   A
ATOM   4984  CE1 PHE A   9      11.639  -5.256  14.889  1.00  5.60   A
ATOM   4985  CE2 PHE A   9      12.589  -7.316  14.085  1.00  5.47   A
ATOM   4986  CZ  PHE A   9      12.158  -6.521  15.142  1.00  5.95   A
ATOM   4987  C   PHE A   9      12.946  -4.517   8.936  1.00  4.36   A
ATOM   4988  O   PHE A   9      13.277  -3.398   8.532  1.00  4.11   A
ATOM   4989  N   ASN A  10      12.354  -5.405   8.146  1.00  4.68   A
ATOM   4990  CA  ASN A  10      12.026  -5.046   6.778  1.00  5.42   A
ATOM   4991  CB  ASN A  10      11.933  -6.278   5.880  1.00  5.82   A
ATOM   4992  CG  ASN A  10      11.502  -5.933   4.465  1.00  6.24   A
ATOM   4993  OD1 ASN A  10      11.787  -4.841   3.954  1.00  6.66   A
ATOM   4994  ND2 ASN A  10      10.822  -6.869   3.814  1.00  7.65   A
ATOM   4995  C   ASN A  10      10.694  -4.319   6.813  1.00  5.70   A
ATOM   4996  O   ASN A  10       9.636  -4.892   6.537  1.00  5.50   A
ATOM   4997  N   MET A  11      10.763  -3.054   7.208  1.00  6.01   A
ATOM   4998  CA  MET A  11       9.597  -2.189   7.287  1.00  6.18   A
ATOM   4999  CB  MET A  11       8.725  -2.548   8.500  1.00  9.09   A
ATOM   5000  CG  MET A  11       9.416  -2.585   9.840  1.00 11.64   A
ATOM   5001  SD  MET A  11       8.242  -3.077  11.159  1.00 15.13   A
ATOM   5002  CE  MET A  11       8.390  -4.861  11.133  1.00 14.75   A
ATOM   5003  C   MET A  11      10.072  -0.749   7.378  1.00  5.10   A
ATOM   5004  O   MET A  11      11.250  -0.502   7.633  1.00  4.65   A
ATOM   5005  N   ARG A  12       9.168   0.193   7.132  1.00  4.17   A
ATOM   5006  CA  ARG A  12       9.518   1.607   7.220  1.00  3.48   A
ATOM   5007  CB  ARG A  12       8.395   2.484   6.640  1.00  3.58   A
ATOM   5008  CG  ARG A  12       8.129   2.254   5.147  1.00  4.20   A
ATOM   5009  CD  ARG A  12       7.130   3.273   4.574  1.00  4.87   A
ATOM   5010  NE  ARG A  12       5.888   3.302   5.344  1.00  5.23   A
ATOM   5011  CZ  ARG A  12       4.941   2.372   5.278  1.00  5.80   A
ATOM   5012  NH1 ARG A  12       5.080   1.336   4.466  1.00  5.95   A
ATOM   5013  NH2 ARG A  12       3.865   2.465   6.052  1.00  5.74   A
ATOM   5014  C   ARG A  12       9.725   1.891   8.704  1.00  2.96   A
ATOM   5015  O   ARG A  12      10.844   2.170   9.144  1.00  2.74   A
ATOM   5016  N   GLY A  13       8.639   1.808   9.466  1.00  2.56   A
ATOM   5017  CA  GLY A  13       8.697   2.009  10.904  1.00  2.19   A
ATOM   5018  C   GLY A  13       9.591   3.120  11.415  1.00  2.22   A
ATOM   5019  O   GLY A  13       9.625   4.212  10.850  1.00  2.01   A
ATOM   5020  N   ARG A  14      10.321   2.833  12.489  1.00  2.32   A
ATOM   5021  CA  ARG A  14      11.192   3.823  13.108  1.00  2.60   A
ATOM   5022  CB  ARG A  14      11.457   3.436  14.570  1.00  2.99   A
ATOM   5023  CG  ARG A  14      10.223   3.584  15.442  1.00  4.04   A
ATOM   5024  CD  ARG A  14      10.492   3.265  16.906  1.00  5.12   A
ATOM   5025  NE  ARG A  14       9.320   3.584  17.718  1.00  6.44   A
ATOM   5026  CZ  ARG A  14       8.960   4.815  18.073  1.00  7.09   A
ATOM   5027  NH1 ARG A  14       9.688   5.867  17.709  1.00  7.50   A
ATOM   5028  NH2 ARG A  14       7.841   4.998  18.765  1.00  7.96   A
ATOM   5029  C   ARG A  14      12.510   4.077  12.392  1.00  2.41   A
ATOM   5030  O   ARG A  14      13.238   4.997  12.750  1.00  2.83   A
ATOM   5031  N   ALA A  15      12.822   3.277  11.378  1.00  2.21   A
ATOM   5032  CA  ALA A  15      14.068   3.484  10.648  1.00  1.80   A
ATOM   5033  CB  ALA A  15      14.627   2.144  10.156  1.00  2.27   A
ATOM   5034  C   ALA A  15      13.858   4.405   9.458  1.00  1.82   A
ATOM   5035  O   ALA A  15      14.815   4.976   8.938  1.00  1.57   A
ATOM   5036  N   GLU A  16      12.610   4.575   9.033  1.00  1.93   A
ATOM   5037  CA  GLU A  16      12.359   5.372   7.840  1.00  1.94   A
ATOM   5038  CB  GLU A  16      10.870   5.346   7.482  1.00  2.14   A
ATOM   5039  CG  GLU A  16      10.579   5.687   6.016  1.00  2.49   A
ATOM   5040  CD  GLU A  16      11.126   4.665   5.011  1.00  3.04   A
ATOM   5041  OE1 GLU A  16      11.667   3.615   5.422  1.00  3.42   A
ATOM   5042  OE2 GLU A  16      11.008   4.916   3.793  1.00  3.55   A
ATOM   5043  C   GLU A  16      12.875   6.801   7.878  1.00  1.89   A
ATOM   5044  O   GLU A  16      13.356   7.302   6.866  1.00  1.73   A
ATOM   5045  N   ILE A  17      12.807   7.460   9.030  1.00  1.19   A
ATOM   5046  CA  ILE A  17      13.306   8.825   9.107  1.00  1.35   A
ATOM   5047  CB  ILE A  17      13.031   9.454  10.510  1.00  1.50   A
ATOM   5048  CG2 ILE A  17      13.702   8.649  11.614  1.00  1.52   A
ATOM   5049  CG1 ILE A  17      13.514  10.909  10.532  1.00  1.26   A
ATOM   5050  CD1 ILE A  17      12.833  11.795   9.501  1.00  1.74   A
ATOM   5051  C   ILE A  17      14.807   8.856   8.760  1.00  1.44   A
ATOM   5052  O   ILE A  17      15.275   9.775   8.079  1.00  2.26   A
ATOM   5242  N   TRP A  39      16.279 -11.644  14.583  1.00 11.83   A
ATOM   5243  CA  TRP A  39      16.330 -10.580  15.586  1.00 11.41   A
ATOM   5244  CB  TRP A  39      14.938  -9.947  15.714  1.00 10.48   A
ATOM   5245  CG  TRP A  39      14.752  -8.981  16.856  1.00  9.62   A
ATOM   5246  CD2 TRP A  39      15.630  -7.913  17.256  1.00  9.22   A
ATOM   5247  CE2 TRP A  39      15.022  -7.269  18.356  1.00  9.06   A
ATOM   5248  CE3 TRP A  39      16.865  -7.439  16.793  1.00  8.94   A
ATOM   5249  CD1 TRP A  39      13.687  -8.935  17.705  1.00  9.52   A
ATOM   5250  NE1 TRP A  39      13.842  -7.915  18.607  1.00  9.30   A
ATOM   5251  CZ2 TRP A  39      15.608  -6.173  19.005  1.00  8.71   A
ATOM   5252  CZ3 TRP A  39      17.450  -6.345  17.442  1.00  8.93   A
ATOM   5253  CH2 TRP A  39      16.817  -5.729  18.536  1.00  8.40   A
ATOM   5254  C   TRP A  39      16.848 -11.032  16.960  1.00 11.66   A
ATOM   5255  O   TRP A  39      17.710 -10.382  17.547  1.00 11.72   A
ATOM   5256  N   PRO A  40      16.337 -12.156  17.487  1.00 12.01   A
ATOM   5257  CD  PRO A  40      15.261 -13.023  16.971  1.00 12.11   A
ATOM   5258  CA  PRO A  40      16.795 -12.629  18.799  1.00 12.31   A
ATOM   5259  CB  PRO A  40      16.171 -14.016  18.894  1.00 12.32   A
ATOM   5260  CG  PRO A  40      14.862 -13.816  18.203  1.00 12.38   A
ATOM   5261  C   PRO A  40      18.308 -12.656  19.023  1.00 12.59   A
ATOM   5262  O   PRO A  40      18.799 -12.163  20.042  1.00 12.72   A
ATOM   5263  N   GLU A  41      19.053 -13.223  18.081  1.00 12.84   A
ATOM   5264  CA  GLU A  41      20.500 -13.309  18.231  1.00 13.09   A
ATOM   5265  CB  GLU A  41      21.054 -14.364  17.270  1.00 14.07   A
ATOM   5266  CG  GLU A  41      20.459 -15.745  17.544  1.00 15.68   A
ATOM   5267  CD  GLU A  41      20.995 -16.831  16.634  1.00 16.54   A
ATOM   5268  OE1 GLU A  41      20.297 -17.854  16.473  1.00 17.39   A
ATOM   5269  OE2 GLU A  41      22.109 -16.677  16.088  1.00 17.54   A
ATOM   5270  C   GLU A  41      21.229 -11.972  18.074  1.00 12.61   A
ATOM   5271  O   GLU A  41      22.373 -11.827  18.506  1.00 12.75   A
ATOM   5272  N   ILE A  42      20.566 -10.995  17.467  1.00 11.99   A
ATOM   5273  CA  ILE A  42      21.160  -9.673  17.307  1.00 11.37   A
ATOM   5274  CB  ILE A  42      20.596  -8.939  16.065  1.00 11.34   A
ATOM   5275  CG2 ILE A  42      20.978  -7.464  16.105  1.00 11.36   A
ATOM   5276  CG1 ILE A  42      21.128  -9.596  14.788  1.00 11.71   A
ATOM   5277  CD1 ILE A  42      20.546  -9.013  13.510  1.00 11.80   A
ATOM   5278  C   ILE A  42      20.819  -8.870  18.561  1.00 11.10   A
ATOM   5279  O   ILE A  42      21.665  -8.178  19.123  1.00 10.73   A
ATOM   5280  N   LYS A  43      19.571  -8.996  19.000  1.00 10.69   A
ATOM   5281  CA  LYS A  43      19.075  -8.292  20.176  1.00 11.07   A
ATOM   5282  CB  LYS A  43      17.665  -8.788  20.506  1.00 10.56   A
ATOM   5283  CG  LYS A  43      17.027  -8.164  21.737  1.00 10.22   A
ATOM   5284  CD  LYS A  43      15.654  -8.770  21.969  1.00 10.10   A
ATOM   5285  CE  LYS A  43      14.982  -8.200  23.204  1.00  9.67   A
ATOM   5286  NZ  LYS A  43      14.601  -6.767  23.037  1.00  9.62   A
ATOM   5287  C   LYS A  43      19.986  -8.462  21.391  1.00 11.41   A
ATOM   5288  O   LYS A  43      20.292  -7.495  22.089  1.00 11.31   A
ATOM   5328  N   GLY A  49      18.949  -3.542  23.669  1.00  8.96   A
ATOM   5329  CA  GLY A  49      18.093  -4.495  22.982  1.00  8.21   A
ATOM   5330  C   GLY A  49      16.991  -3.983  22.078  1.00  7.54   A
ATOM   5331  O   GLY A  49      15.959  -4.642  21.937  1.00  7.64   A
ATOM   5332  N   LYS A  50      17.203  -2.832  21.444  1.00  6.95   A
ATOM   5333  CA  LYS A  50      16.197  -2.263  20.554  1.00  6.45   A
ATOM   5334  CB  LYS A  50      15.528  -1.042  21.199  1.00  7.37   A
ATOM   5335  CG  LYS A  50      14.831  -1.283  22.528  1.00  9.43   A
ATOM   5336  CD  LYS A  50      13.634  -2.197  22.385  1.00 10.69   A
ATOM   5337  CE  LYS A  50      12.660  -2.004  23.550  1.00 11.86   A
ATOM   5338  NZ  LYS A  50      13.354  -1.838  24.858  1.00 12.34   A
ATOM   5339  C   LYS A  50      16.803  -1.810  19.233  1.00  5.62   A
ATOM   5340  O   LYS A  50      17.999  -1.515  19.152  1.00  4.99   A
ATOM   5341  N   ILE A  51      15.968  -1.766  18.198  1.00  4.81   A
ATOM   5342  CA  ILE A  51      16.386  -1.277  16.892  1.00  4.23   A
ATOM   5343  CB  ILE A  51      16.427  -2.400  15.821  1.00  4.50   A
ATOM   5344  CG2 ILE A  51      17.736  -3.173  15.951  1.00  4.04   A
ATOM   5345  CG1 ILE A  51      15.214  -3.320  15.954  1.00  4.67   A
ATOM   5346  CD1 ILE A  51      15.125  -4.353  14.851  1.00  5.01   A
ATOM   5347  C   ILE A  51      15.403  -0.173  16.503  1.00  3.91   A
ATOM   5348  O   ILE A  51      14.295  -0.096  17.037  1.00  3.85   A
ATOM   5349  N   PRO A  52      15.769   0.677  15.540  1.00  3.47   A
ATOM   5350  CD  PRO A  52      14.929   1.849  15.221  1.00  3.53   A
ATOM   5351  CA  PRO A  52      17.011   0.704  14.767  1.00  3.15   A
ATOM   5352  CB  PRO A  52      16.712   1.735  13.687  1.00  3.26   A
ATOM   5353  CG  PRO A  52      15.878   2.741  14.442  1.00  3.38   A
ATOM   5354  C   PRO A  52      18.294   1.063  15.490  1.00  3.11   A
ATOM   5355  O   PRO A  52      18.288   1.690  16.547  1.00  3.03   A
ATOM   5356  N   ILE A  53      19.394   0.632  14.887  1.00  3.27   A
ATOM   5357  CA  ILE A  53      20.723   0.974  15.351  1.00  3.18   A
ATOM   5358  CB  ILE A  53      21.495  -0.199  16.021  1.00  3.72   A
ATOM   5359  CG2 ILE A  53      20.858  -0.553  17.356  1.00  4.09   A
ATOM   5360  CG1 ILE A  53      21.596  -1.386  15.064  1.00  4.16   A
ATOM   5361  CD1 ILE A  53      22.466  -2.510  15.594  1.00  5.20   A
ATOM   5362  C   ILE A  53      21.453   1.369  14.074  1.00  3.15   A
ATOM   5363  O   ILE A  53      21.090   0.928  12.978  1.00  2.64   A
ATOM   5423  N   HIS A  62      22.206   4.210  18.799  1.00  3.50   A
ATOM   5424  CA  HIS A  62      20.835   3.722  18.927  1.00  2.95   A
ATOM   5425  CB  HIS A  62      20.705   2.722  20.090  1.00  3.26   A
ATOM   5426  CG  HIS A  62      20.931   3.318  21.445  1.00  3.82   A
ATOM   5427  CD2 HIS A  62      22.047   3.813  22.031  1.00  3.92   A
ATOM   5428  ND1 HIS A  62      19.923   3.438  22.376  1.00  4.07   A
ATOM   5429  CE1 HIS A  62      20.406   3.984  23.478  1.00  3.93   A
ATOM   5430  NE2 HIS A  62      21.692   4.222  23.295  1.00  4.38   A
ATOM   5431  C   HIS A  62      19.890   4.910  19.100  1.00  2.81   A
ATOM   5432  O   HIS A  62      20.342   6.050  19.215  1.00  2.85   A
ATOM   5433  N   GLN A  63      18.586   4.624  19.094  1.00  2.56   A
ATOM   5434  CA  GLN A  63      17.501   5.612  19.201  1.00  2.38   A
ATOM   5435  CB  GLN A  63      17.730   6.586  20.366  1.00  2.32   A
ATOM   5436  CG  GLN A  63      17.350   6.000  21.730  1.00  2.96   A
ATOM   5437  CD  GLN A  63      15.851   5.823  21.898  1.00  3.14   A
ATOM   5438  OE1 GLN A  63      15.063   6.295  21.081  1.00  3.72   A
ATOM   5439  NE2 GLN A  63      15.449   5.151  22.971  1.00  3.70   A
ATOM   5440  C   GLN A  63      17.348   6.359  17.878  1.00  2.37   A
ATOM   5441  O   GLN A  63      18.164   7.212  17.516  1.00  2.00   A
ATOM   5442  N   SER A  64      16.279   6.028  17.160  1.00  2.43   A
ATOM   5443  CA  SER A  64      16.037   6.600  15.841  1.00  2.49   A
ATOM   5444  CB  SER A  64      14.678   6.132  15.296  1.00  2.81   A
ATOM   5445  OG  SER A  64      13.591   6.666  16.036  1.00  3.28   A
ATOM   5446  C   SER A  64      16.138   8.113  15.705  1.00  2.23   A
ATOM   5447  O   SER A  64      16.742   8.603  14.750  1.00  2.28   A
ATOM   5448  N   LEU A  65      15.553   8.854  16.639  1.00  2.47   A
ATOM   5449  CA  LEU A  65      15.581  10.307  16.548  1.00  2.69   A
ATOM   5450  CB  LEU A  65      14.465  10.899  17.409  1.00  3.06   A
ATOM   5451  CG  LEU A  65      13.100  10.321  17.010  1.00  3.16   A
ATOM   5452  CD1 LEU A  65      11.993  10.980  17.835  1.00  4.12   A
ATOM   5453  CD2 LEU A  65      12.854  10.538  15.522  1.00  3.74   A
ATOM   5454  C   LEU A  65      16.935  10.886  16.925  1.00  2.92   A
ATOM   5455  O   LEU A  65      17.330  11.935  16.411  1.00  3.32   A
ATOM   5662  N   ASP A  93       9.345  15.416  18.542  1.00  3.67   A
ATOM   5663  CA  ASP A  93       8.972  14.730  19.781  1.00  3.91   A
ATOM   5664  CB  ASP A  93       9.654  15.361  20.997  1.00  5.09   A
ATOM   5665  CG  ASP A  93      11.041  14.797  21.243  1.00  6.18   A
ATOM   5666  OD1 ASP A  93      11.674  15.203  22.246  1.00  7.93   A
ATOM   5667  OD2 ASP A  93      11.495  13.945  20.442  1.00  7.01   A
ATOM   5668  C   ASP A  93       7.462  14.714  19.985  1.00  3.61   A
ATOM   5669  O   ASP A  93       6.926  13.766  20.539  1.00  3.01   A
ATOM   5670  N   THR A  94       6.776  15.762  19.540  1.00  3.46   A
ATOM   5671  CA  THR A  94       5.325  15.808  19.676  1.00  3.57   A
ATOM   5672  CB  THR A  94       4.792  17.195  19.258  1.00  3.73   A
ATOM   5673  OG1 THR A  94       5.167  18.152  20.257  1.00  4.06   A
ATOM   5674  CG2 THR A  94       3.273  17.186  19.101  1.00  3.88   A
ATOM   5675  C   THR A  94       4.721  14.702  18.811  1.00  3.74   A
ATOM   5676  O   THR A  94       3.789  14.001  19.223  1.00  3.84   A
ATOM   5677  N   LEU A  95       5.268  14.520  17.618  1.00  3.30   A
ATOM   5678  CA  LEU A  95       4.766  13.475  16.740  1.00  3.42   A
ATOM   5679  CB  LEU A  95       5.377  13.609  15.346  1.00  3.94   A
ATOM   5680  CG  LEU A  95       4.919  14.812  14.518  1.00  4.38   A
ATOM   5681  CD1 LEU A  95       5.763  14.924  13.245  1.00  4.83   A
ATOM   5682  CD2 LEU A  95       3.444  14.650  14.184  1.00  5.05   A
ATOM   5683  C   LEU A  95       5.117  12.113  17.323  1.00  3.25   A
ATOM   5684  O   LEU A  95       4.275  11.217  17.397  1.00  3.09   A
ATOM   5685  N   ASP A  96       6.364  11.960  17.756  1.00  3.25   A
ATOM   5686  CA  ASP A  96       6.796  10.687  18.305  1.00  3.69   A
ATOM   5687  CB  ASP A  96       8.301  10.702  18.585  1.00  4.27   A
ATOM   5688  CG  ASP A  96       8.891   9.305  18.644  1.00  4.99   A
ATOM   5689  OD1 ASP A  96       8.774   8.574  17.637  1.00  6.02   A
ATOM   5690  OD2 ASP A  96       9.478   8.933  19.684  1.00  6.06   A
ATOM   5691  C   ASP A  96       6.038  10.316  19.573  1.00  3.81   A
ATOM   5692  O   ASP A  96       5.791   9.137  19.819  1.00  3.60   A
ATOM   5693  N   ASP A  97       5.677  11.315  20.377  1.00  3.85   A
ATOM   5694  CA  ASP A  97       4.924  11.062  21.608  1.00  4.32   A
ATOM   5695  CB  ASP A  97       4.600  12.377  22.332  1.00  5.15   A
ATOM   5696  CG  ASP A  97       5.754  12.898  23.172  1.00  5.96   A
ATOM   5697  OD1 ASP A  97       5.657  14.053  23.647  1.00  6.78   A
ATOM   5698  OD2 ASP A  97       6.748  12.163  23.377  1.00  6.61   A
ATOM   5699  C   ASP A  97       3.614  10.355  21.261  1.00  4.57   A
ATOM   5700  O   ASP A  97       3.214   9.403  21.931  1.00  4.45   A
ATOM   5701  N   PHE A  98       2.947  10.823  20.210  1.00  4.32   A
ATOM   5702  CA  PHE A  98       1.680  10.219  19.809  1.00  4.70   A
ATOM   5703  CB  PHE A  98       0.956  11.086  18.778  1.00  5.18   A
ATOM   5704  CG  PHE A  98      -0.415  10.574  18.423  1.00  5.70   A
ATOM   5705  CD1 PHE A  98      -1.420  10.518  19.385  1.00  6.58   A
ATOM   5706  CD2 PHE A  98      -0.690  10.107  17.144  1.00  6.14   A
ATOM   5707  CE1 PHE A  98      -2.681  10.001  19.077  1.00  6.93   A
ATOM   5708  CE2 PHE A  98      -1.950   9.587  16.825  1.00  6.50   A
ATOM   5709  CZ  PHE A  98      -2.945   9.534  17.798  1.00  6.64   A
ATOM   5710  C   PHE A  98       1.876   8.825  19.232  1.00  4.66   A
ATOM   5711  O   PHE A  98       1.147   7.896  19.574  1.00  4.59   A
ATOM   5712  N   MET A  99       2.857   8.678  18.352  1.00  4.84   A
ATOM   5713  CA  MET A  99       3.117   7.377  17.749  1.00  5.40   A
ATOM   5714  CB  MET A  99       4.299   7.464  16.777  1.00  5.46   A
ATOM   5715  CG  MET A  99       4.123   8.469  15.638  1.00  5.83   A
ATOM   5716  SD  MET A  99       2.682   8.141  14.594  1.00  6.06   A
ATOM   5717  CE  MET A  99       3.312   6.790  13.572  1.00  6.22   A
ATOM   5718  C   MET A  99       3.420   6.339  18.832  1.00  6.00   A
ATOM   5719  O   MET A  99       2.994   5.188  18.739  1.00  6.05   A
ATOM   5720  N   SER A 100       4.143   6.759  19.866  1.00  6.83   A
ATOM   5721  CA  SER A 100       4.523   5.860  20.951  1.00  8.20   A
ATOM   5722  CB  SER A 100       5.628   6.516  21.790  1.00  7.84   A
ATOM   5723  OG  SER A 100       6.767   6.802  20.987  1.00  8.21   A
ATOM   5724  C   SER A 100       3.367   5.412  21.854  1.00  9.33   A
ATOM   5725  O   SER A 100       3.524   4.476  22.646  1.00  9.63   A
ATOM   5726  N   CYS A 101       2.211   6.062  21.721  1.00 10.45   A
ATOM   5727  CA  CYS A 101       1.029   5.738  22.528  1.00 12.16   A
ATOM   5728  CB  CYS A 101      -0.005   6.870  22.455  1.00 12.99   A
ATOM   5729  SG  CYS A 101       0.391   8.383  23.352  1.00 16.33   A
ATOM   5730  C   CYS A 101       0.334   4.450  22.106  1.00 12.31   A
ATOM   5731  O   CYS A 101      -0.382   3.836  22.900  1.00 12.62   A
ATOM   5732  N   PHE A 102       0.526   4.044  20.857  1.00 12.65   A
ATOM   5733  CA  PHE A 102      -0.137   2.843  20.368  1.00 13.00   A
ATOM   5734  CB  PHE A 102      -0.054   2.787  18.844  1.00 12.20   A
ATOM   5735  CG  PHE A 102      -0.888   3.838  18.165  1.00 11.64   A
ATOM   5736  CD1 PHE A 102      -0.514   5.179  18.211  1.00 11.24   A
ATOM   5737  CD2 PHE A 102      -2.065   3.493  17.507  1.00 11.38   A
ATOM   5738  CE1 PHE A 102      -1.297   6.164  17.610  1.00 11.11   A
ATOM   5739  CE2 PHE A 102      -2.858   4.468  16.902  1.00 11.06   A
ATOM   5740  CZ  PHE A 102      -2.474   5.809  16.953  1.00 10.93   A
ATOM   5741  C   PHE A 102       0.382   1.557  20.998  1.00 13.83   A
ATOM   5742  O   PHE A 102       1.580   1.275  20.975  1.00 13.59   A
ATOM   5743  N   PRO A 103      -0.537   0.762  21.579  1.00 14.74   A
ATOM   5744  CD  PRO A 103      -1.976   1.093  21.609  1.00 14.92   A
ATOM   5745  CA  PRO A 103      -0.297  -0.516  22.259  1.00 15.72   A
ATOM   5746  CB  PRO A 103      -1.578  -0.707  23.061  1.00 15.57   A
ATOM   5747  CG  PRO A 103      -2.608  -0.199  22.114  1.00 15.22   A
ATOM   5748  C   PRO A 103      -0.008  -1.711  21.354  1.00 16.75   A
ATOM   5749  O   PRO A 103      -0.814  -2.639  21.265  1.00 16.71   A
ATOM   5750  N   TRP A 104       1.146  -1.693  20.697  1.00 17.88   A
ATOM   5751  CA  TRP A 104       1.527  -2.786  19.812  1.00 19.32   A
ATOM   5752  CB  TRP A 104       2.792  -2.423  19.032  1.00 18.89   A
ATOM   5753  CG  TRP A 104       2.548  -1.458  17.925  1.00 18.58   A
ATOM   5754  CD2 TRP A 104       2.010  -1.762  16.635  1.00 18.48   A
ATOM   5755  CE2 TRP A 104       1.931  -0.548  15.918  1.00 18.52   A
ATOM   5756  CE3 TRP A 104       1.584  -2.944  16.015  1.00 18.55   A
ATOM   5757  CD1 TRP A 104       2.767  -0.110  17.942  1.00 18.43   A
ATOM   5758  NE1 TRP A 104       2.400   0.444  16.739  1.00 18.43   A
ATOM   5759  CZ2 TRP A 104       1.443  -0.481  14.610  1.00 18.51   A
ATOM   5760  CZ3 TRP A 104       1.099  -2.877  14.712  1.00 18.61   A
ATOM   5761  CH2 TRP A 104       1.033  -1.651  14.026  1.00 18.57   A
ATOM   5762  C   TRP A 104       1.756  -4.094  20.562  1.00 20.48   A
ATOM   5763  O   TRP A 104       1.734  -5.170  19.964  1.00 20.69   A
ATOM   5764  N   ALA A 105       1.965  -4.000  21.870  1.00 21.92   A
ATOM   5765  CA  ALA A 105       2.214  -5.182  22.688  1.00 23.42   A
ATOM   5766  CB  ALA A 105       3.036  -4.796  23.914  1.00 23.28   A
ATOM   5767  C   ALA A 105       0.943  -5.910  23.120  1.00 24.45   A
ATOM   5768  O   ALA A 105       1.013  -6.976  23.732  1.00 24.65   A
ATOM   5769  N   GLU A 106      -0.217  -5.342  22.802  1.00 25.65   A
ATOM   5770  CA  GLU A 106      -1.485  -5.962  23.174  1.00 26.85   A
ATOM   5771  CB  GLU A 106      -2.660  -5.132  22.655  1.00 27.04   A
ATOM   5772  CG  GLU A 106      -4.013  -5.813  22.819  1.00 27.53   A
ATOM   5773  CD  GLU A 106      -4.291  -6.224  24.252  1.00 27.76   A
ATOM   5774  OE1 GLU A 106      -4.226  -5.354  25.146  1.00 27.91   A
ATOM   5775  OE2 GLU A 106      -4.580  -7.417  24.484  1.00 28.01   A
ATOM   5776  C   GLU A 106      -1.599  -7.391  22.649  1.00 27.52   A
ATOM   5777  O   GLU A 106      -1.223  -7.680  21.512  1.00 27.83   A
ATOM   5778  N   LYS A 107      -2.130  -8.275  23.487  1.00 28.30   A
ATOM   5779  CA  LYS A 107      -2.300  -9.682  23.139  1.00 28.87   A
ATOM   5780  CB  LYS A 107      -2.444 -10.514  24.414  1.00 29.16   A
ATOM   5781  CG  LYS A 107      -1.271 -10.395  25.373  1.00 29.57   A
ATOM   5782  CD  LYS A 107       0.009 -10.925  24.750  1.00 29.90   A
ATOM   5783  CE  LYS A 107       1.156 -10.889  25.748  1.00 30.13   A
ATOM   5784  NZ  LYS A 107       0.857 -11.708  26.956  1.00 30.43   A
ATOM   5785  C   LYS A 107      -3.509  -9.927  22.241  1.00 29.12   A
ATOM   5786  O   LYS A 107      -3.376 -10.446  21.132  1.00 29.28   A
ATOM   5787  N   LYS A 108      -4.689  -9.560  22.729  1.00 29.38   A
ATOM   5788  CA  LYS A 108      -5.921  -9.745  21.972  1.00 29.63   A
ATOM   5789  CB  LYS A 108      -7.134  -9.496  22.872  1.00 30.00   A
ATOM   5790  CG  LYS A 108      -7.169 -10.367  24.123  1.00 30.56   A
ATOM   5791  CD  LYS A 108      -8.456 -10.178  24.922  1.00 30.98   A
ATOM   5792  CE  LYS A 108      -9.673 -10.768  24.211  1.00 31.33   A
ATOM   5793  NZ  LYS A 108      -9.995 -10.085  22.924  1.00 31.67   A
ATOM   5794  C   LYS A 108      -5.969  -8.806  20.773  1.00 29.56   A
ATOM   5795  O   LYS A 108      -6.053  -7.588  20.929  1.00 29.53   A
ATOM   5796  N   GLN A 109      -5.912  -9.380  19.575  1.00 29.46   A
ATOM   5797  CA  GLN A 109      -5.950  -8.594  18.348  1.00 29.31   A
ATOM   5798  CB  GLN A 109      -5.908  -9.519  17.130  1.00 29.60   A
ATOM   5799  CG  GLN A 109      -5.886  -8.795  15.788  1.00 30.07   A
ATOM   5800  CD  GLN A 109      -4.671  -7.898  15.624  1.00 30.20   A
ATOM   5801  OE1 GLN A 109      -3.531  -8.347  15.745  1.00 30.51   A
ATOM   5802  NE2 GLN A 109      -4.911  -6.623  15.341  1.00 30.44   A
ATOM   5803  C   GLN A 109      -7.213  -7.740  18.306  1.00 29.07   A
ATOM   5804  O   GLN A 109      -7.197  -6.614  17.808  1.00 29.12   A
ATOM   5805  N   ASP A 110      -8.304  -8.281  18.838  1.00 28.67   A
ATOM   5806  CA  ASP A 110      -9.582  -7.576  18.871  1.00 28.20   A
ATOM   5807  CB  ASP A 110     -10.662  -8.464  19.494  1.00 28.84   A
ATOM   5808  CG  ASP A 110     -10.698  -9.855  18.892  1.00 29.35   A
ATOM   5809  OD1 ASP A 110     -11.510 -10.681  19.362  1.00 29.82   A
ATOM   5810  OD2 ASP A 110      -9.918 -10.126  17.954  1.00 29.79   A
ATOM   5811  C   ASP A 110      -9.450  -6.303  19.700  1.00 27.49   A
ATOM   5812  O   ASP A 110      -9.794  -5.210  19.248  1.00 27.41   A
ATOM   5813  N   VAL A 111      -8.952  -6.466  20.921  1.00 26.54   A
ATOM   5814  CA  VAL A 111      -8.765  -5.352  21.844  1.00 25.62   A
ATOM   5815  CB  VAL A 111      -8.261  -5.852  23.214  1.00 25.70   A
ATOM   5816  CG1 VAL A 111      -8.118  -4.687  24.176  1.00 25.75   A
ATOM   5817  CG2 VAL A 111      -9.220  -6.892  23.769  1.00 25.72   A
ATOM   5818  C   VAL A 111      -7.751  -4.361  21.288  1.00 24.87   A
ATOM   5819  O   VAL A 111      -7.890  -3.150  21.457  1.00 24.76   A
ATOM   5820  N   LYS A 112      -6.733  -4.893  20.623  1.00 23.93   A
ATOM   5821  CA  LYS A 112      -5.679  -4.082  20.034  1.00 22.97   A
ATOM   5822  CB  LYS A 112      -4.645  -4.995  19.376  1.00 23.32   A
ATOM   5823  CG  LYS A 112      -3.397  -4.302  18.873  1.00 23.86   A
ATOM   5824  CD  LYS A 112      -2.432  -5.333  18.305  1.00 24.32   A
ATOM   5825  CE  LYS A 112      -1.157  -4.697  17.788  1.00 24.73   A
ATOM   5826  NZ  LYS A 112      -0.215  -5.733  17.271  1.00 25.05   A
ATOM   5827  C   LYS A 112      -6.259  -3.114  19.007  1.00 22.11   A
ATOM   5828  O   LYS A 112      -5.962  -1.920  19.031  1.00 21.79   A
ATOM   5829  N   GLU A 113      -7.092  -3.636  18.111  1.00 21.14   A
ATOM   5830  CA  GLU A 113      -7.715  -2.815  17.079  1.00 20.14   A
ATOM   5831  CB  GLU A 113      -8.529  -3.690  16.119  1.00 20.72   A
ATOM   5832  CG  GLU A 113      -7.713  -4.763  15.412  1.00 21.85   A
ATOM   5833  CD  GLU A 113      -8.491  -5.456  14.303  1.00 22.40   A
ATOM   5834  OE1 GLU A 113      -7.956  -6.422  13.717  1.00 22.88   A
ATOM   5835  OE2 GLU A 113      -9.632  -5.032  14.010  1.00 23.04   A
ATOM   5836  C   GLU A 113      -8.623  -1.766  17.712  1.00 19.20   A
ATOM   5837  O   GLU A 113      -8.699  -0.632  17.240  1.00 18.59   A
ATOM   5838  N   GLN A 114      -9.313  -2.157  18.780  1.00 18.24   A
ATOM   5839  CA  GLN A 114     -10.211  -1.252  19.492  1.00 17.58   A
ATOM   5840  CB  GLN A 114     -10.867  -1.989  20.665  1.00 18.40   A
ATOM   5841  CG  GLN A 114     -11.701  -1.110  21.590  1.00 19.72   A
ATOM   5842  CD  GLN A 114     -12.983  -0.617  20.951  1.00 20.35   A
ATOM   5843  OE1 GLN A 114     -13.741   0.141  21.560  1.00 21.36   A
ATOM   5844  NE2 GLN A 114     -13.238  -1.045  19.721  1.00 21.11   A
ATOM   5845  C   GLN A 114      -9.433  -0.044  20.011  1.00 16.47   A
ATOM   5846  O   GLN A 114      -9.841   1.101  19.822  1.00 15.90   A
ATOM   5847  N   MET A 115      -8.306  -0.308  20.664  1.00 15.39   A
ATOM   5848  CA  MET A 115      -7.469   0.754  21.215  1.00 14.42   A
ATOM   5849  CB  MET A 115      -6.325   0.146  22.022  1.00 15.54   A
ATOM   5850  CG  MET A 115      -6.800  -0.675  23.205  1.00 16.96   A
ATOM   5851  SD  MET A 115      -5.448  -1.470  24.079  1.00 18.84   A
ATOM   5852  CE  MET A 115      -5.262  -2.923  23.139  1.00 18.77   A
ATOM   5853  C   MET A 115      -6.912   1.655  20.117  1.00 13.19   A
ATOM   5854  O   MET A 115      -6.872   2.877  20.267  1.00 12.74   A
ATOM   5855  N   PHE A 116      -6.476   1.050  19.017  1.00 11.78   A
ATOM   5856  CA  PHE A 116      -5.947   1.813  17.890  1.00 10.59   A
ATOM   5857  CB  PHE A 116      -5.490   0.870  16.773  1.00 10.36   A
ATOM   5858  CG  PHE A 116      -4.061   0.413  16.901  1.00 10.46   A
ATOM   5859  CD1 PHE A 116      -3.595  -0.162  18.081  1.00 10.57   A
ATOM   5860  CD2 PHE A 116      -3.180   0.559  15.836  1.00 10.60   A
ATOM   5861  CE1 PHE A 116      -2.264  -0.584  18.196  1.00 10.91   A
ATOM   5862  CE2 PHE A 116      -1.850   0.140  15.940  1.00 10.80   A
ATOM   5863  CZ  PHE A 116      -1.395  -0.431  17.123  1.00 10.66   A
ATOM   5864  C   PHE A 116      -7.028   2.746  17.352  1.00  9.91   A
ATOM   5865  O   PHE A 116      -6.784   3.926  17.107  1.00  9.44   A
ATOM   6152  N   TYR A 152       9.540  13.762   9.073  1.00  2.77   A
ATOM   6153  CA  TYR A 152       8.881  12.942  10.085  1.00  2.75   A
ATOM   6154  CB  TYR A 152       9.375  13.285  11.493  1.00  2.46   A
ATOM   6155  CG  TYR A 152       9.275  12.107  12.439  1.00  2.52   A
ATOM   6156  CD1 TYR A 152       9.745  10.850  12.057  1.00  2.65   A
ATOM   6157  CE1 TYR A 152       9.704   9.767  12.931  1.00  2.76   A
ATOM   6158  CD2 TYR A 152       8.749  12.251  13.727  1.00  2.68   A
ATOM   6159  CE2 TYR A 152       8.700  11.166  14.614  1.00  2.62   A
ATOM   6160  CZ  TYR A 152       9.187   9.928  14.206  1.00  2.82   A
ATOM   6161  OH  TYR A 152       9.200   8.848  15.069  1.00  3.50   A
ATOM   6162  C   TYR A 152       7.367  13.051  10.016  1.00  2.91   A
ATOM   6163  O   TYR A 152       6.660  12.070  10.255  1.00  2.96   A
ATOM   6164  N   TRP A 153       6.863  14.237   9.696  1.00  3.18   A
ATOM   6165  CA  TRP A 153       5.424  14.392   9.562  1.00  3.43   A
ATOM   6166  CB  TRP A 153       5.044  15.839   9.240  1.00  3.92   A
ATOM   6167  CG  TRP A 153       3.631  15.957   8.702  1.00  4.79   A
ATOM   6168  CD2 TRP A 153       2.425  15.511   9.340  1.00  5.21   A
ATOM   6169  CE2 TRP A 153       1.359  15.767   8.446  1.00  5.55   A
ATOM   6170  CE3 TRP A 153       2.141  14.917  10.578  1.00  5.42   A
ATOM   6171  CD1 TRP A 153       3.256  16.454   7.485  1.00  5.26   A
ATOM   6172  NE1 TRP A 153       1.894  16.341   7.324  1.00  5.61   A
ATOM   6173  CZ2 TRP A 153       0.029  15.449   8.749  1.00  5.49   A
ATOM   6174  CZ3 TRP A 153       0.812  14.599  10.880  1.00  5.68   A
ATOM   6175  CH2 TRP A 153      -0.223  14.868   9.967  1.00  5.61   A
ATOM   6176  C   TRP A 153       4.929  13.497   8.428  1.00  3.45   A
ATOM   6177  O   TRP A 153       3.935  12.797   8.576  1.00  3.37   A
ATOM   6178  N   GLU A 154       5.618  13.518   7.291  1.00  3.56   A
ATOM   6179  CA  GLU A 154       5.176  12.711   6.162  1.00  3.71   A
ATOM   6180  CB  GLU A 154       5.999  13.035   4.908  1.00  4.32   A
ATOM   6181  CG  GLU A 154       5.412  12.438   3.622  1.00  5.29   A
ATOM   6182  CD  GLU A 154       5.831  11.001   3.395  1.00  6.03   A
ATOM   6183  OE1 GLU A 154       5.164  10.291   2.610  1.00  7.04   A
ATOM   6184  OE2 GLU A 154       6.840  10.587   3.991  1.00  6.58   A
ATOM   6185  C   GLU A 154       5.242  11.218   6.467  1.00  3.29   A
ATOM   6186  O   GLU A 154       4.349  10.463   6.092  1.00  3.50   A
ATOM   6187  N   ILE A 155       6.290  10.801   7.166  1.00  3.02   A
ATOM   6188  CA  ILE A 155       6.466   9.397   7.520  1.00  3.13   A
ATOM   6189  CB  ILE A 155       7.888   9.182   8.105  1.00  2.70   A
ATOM   6190  CG2 ILE A 155       7.991   7.836   8.827  1.00  2.70   A
ATOM   6191  CG1 ILE A 155       8.912   9.275   6.974  1.00  2.60   A
ATOM   6192  CD1 ILE A 155      10.341   9.455   7.455  1.00  2.55   A
ATOM   6193  C   ILE A 155       5.393   8.931   8.509  1.00  3.34   A
ATOM   6194  O   ILE A 155       4.757   7.888   8.304  1.00  3.01   A
ATOM   6195  N   CYS A 156       5.178   9.708   9.570  1.00  3.50   A
ATOM   6196  CA  CYS A 156       4.176   9.345  10.570  1.00  4.03   A
ATOM   6197  CB  CYS A 156       4.227  10.298  11.771  1.00  4.29   A
ATOM   6198  SG  CYS A 156       5.678  10.099  12.840  1.00  5.23   A
ATOM   6199  C   CYS A 156       2.767   9.339   9.989  1.00  4.27   A
ATOM   6200  O   CYS A 156       2.009   8.390  10.199  1.00  4.23   A
ATOM   6201  N   SER A 157       2.419  10.391   9.254  1.00  4.32   A
ATOM   6202  CA  SER A 157       1.085  10.469   8.668  1.00  4.75   A
ATOM   6203  CB  SER A 157       0.838  11.865   8.072  1.00  5.10   A
ATOM   6204  OG  SER A 157       1.761  12.194   7.047  1.00  5.43   A
ATOM   6205  C   SER A 157       0.852   9.369   7.631  1.00  4.95   A
ATOM   6206  O   SER A 157      -0.264   8.874   7.487  1.00  4.57   A
ATOM   6207  N   THR A 158       1.898   8.963   6.920  1.00  5.02   A
ATOM   6208  CA  THR A 158       1.731   7.901   5.937  1.00  5.46   A
ATOM   6209  CB  THR A 158       3.044   7.623   5.168  1.00  5.08   A
ATOM   6210  OG1 THR A 158       3.223   8.638   4.175  1.00  6.03   A
ATOM   6211  CG2 THR A 158       3.002   6.255   4.484  1.00  5.35   A
ATOM   6212  C   THR A 158       1.257   6.624   6.623  1.00  5.78   A
ATOM   6213  O   THR A 158       0.330   5.963   6.153  1.00  6.22   A
ATOM   6214  N   THR A 159       1.868   6.273   7.749  1.00  6.08   A
ATOM   6215  CA  THR A 159       1.439   5.056   8.416  1.00  6.86   A
ATOM   6216  CB  THR A 159       2.511   4.534   9.380  1.00  7.60   A
ATOM   6217  OG1 THR A 159       3.698   4.230   8.633  1.00  8.88   A
ATOM   6218  CG2 THR A 159       2.029   3.261  10.065  1.00  8.45   A
ATOM   6219  C   THR A 159       0.102   5.219   9.141  1.00  6.36   A
ATOM   6220  O   THR A 159      -0.716   4.304   9.136  1.00  6.28   A
ATOM   6221  N   LEU A 160      -0.139   6.378   9.749  1.00  6.36   A
ATOM   6222  CA  LEU A 160      -1.416   6.583  10.433  1.00  6.28   A
ATOM   6223  CB  LEU A 160      -1.442   7.938  11.145  1.00  6.43   A
ATOM   6224  CG  LEU A 160      -0.494   8.064  12.344  1.00  6.55   A
ATOM   6225  CD1 LEU A 160      -0.635   9.446  12.969  1.00  6.99   A
ATOM   6226  CD2 LEU A 160      -0.815   6.977  13.369  1.00  6.80   A
ATOM   6227  C   LEU A 160      -2.567   6.505   9.428  1.00  6.52   A
ATOM   6228  O   LEU A 160      -3.635   5.979   9.744  1.00  6.37   A
ATOM   6229  N   LEU A 161      -2.344   7.026   8.224  1.00  6.39   A
ATOM   6230  CA  LEU A 161      -3.369   7.006   7.178  1.00  6.80   A
ATOM   6231  CB  LEU A 161      -2.881   7.764   5.941  1.00  6.77   A
ATOM   6232  CG  LEU A 161      -2.994   9.287   6.026  1.00  6.85   A
ATOM   6233  CD1 LEU A 161      -2.211   9.934   4.893  1.00  6.96   A
ATOM   6234  CD2 LEU A 161      -4.468   9.686   5.967  1.00  6.94   A
ATOM   6235  C   LEU A 161      -3.770   5.589   6.785  1.00  6.97   A
ATOM   6236  O   LEU A 161      -4.869   5.370   6.272  1.00  7.11   A
ATOM   6237  N   VAL A 162      -2.884   4.627   7.015  1.00  7.20   A
ATOM   6238  CA  VAL A 162      -3.199   3.240   6.692  1.00  7.82   A
ATOM   6239  CB  VAL A 162      -1.963   2.317   6.867  1.00  7.65   A
ATOM   6240  CG1 VAL A 162      -2.372   0.853   6.720  1.00  8.05   A
ATOM   6241  CG2 VAL A 162      -0.905   2.673   5.830  1.00  7.94   A
ATOM   6242  C   VAL A 162      -4.308   2.760   7.620  1.00  8.18   A
ATOM   6243  O   VAL A 162      -5.197   2.014   7.205  1.00  8.53   A
ATOM   6244  N   PHE A 163      -4.257   3.204   8.875  1.00  8.35   A
ATOM   6245  CA  PHE A 163      -5.251   2.813   9.871  1.00  8.79   A
ATOM   6246  CB  PHE A 163      -4.612   2.753  11.263  1.00  9.22   A
ATOM   6247  CG  PHE A 163      -3.511   1.746  11.376  1.00 10.12   A
ATOM   6248  CD1 PHE A 163      -2.201   2.083  11.058  1.00 10.55   A
ATOM   6249  CD2 PHE A 163      -3.792   0.440  11.773  1.00 10.59   A
ATOM   6250  CE1 PHE A 163      -1.186   1.129  11.135  1.00 10.94   A
ATOM   6251  CE2 PHE A 163      -2.787  -0.515  11.850  1.00 11.22   A
ATOM   6252  CZ  PHE A 163      -1.481  -0.169  11.530  1.00 11.03   A
ATOM   6253  C   PHE A 163      -6.454   3.745   9.920  1.00  8.73   A
ATOM   6254  O   PHE A 163      -7.541   3.341  10.333  1.00  9.27   A
ATOM   6528  N   THR A 197       6.261  -2.354   2.065  1.00  5.54   A
ATOM   6529  CA  THR A 197       5.873  -3.026   3.294  1.00  6.03   A
ATOM   6530  CB  THR A 197       7.027  -2.988   4.330  1.00  6.06   A
ATOM   6531  OG1 THR A 197       7.395  -1.626   4.585  1.00  6.14   A
ATOM   6532  CG2 THR A 197       8.251  -3.733   3.796  1.00  6.10   A
ATOM   6533  C   THR A 197       4.634  -2.343   3.865  1.00  6.45   A
ATOM   6534  O   THR A 197       4.355  -1.181   3.559  1.00  6.41   A
ATOM   6535  N   LYS A 198       3.889  -3.065   4.691  1.00  7.24   A
ATOM   6536  CA  LYS A 198       2.679  -2.512   5.272  1.00  7.84   A
ATOM   6537  CB  LYS A 198       1.929  -3.596   6.046  1.00  8.50   A
ATOM   6538  CG  LYS A 198       0.529  -3.190   6.464  1.00  9.42   A
ATOM   6539  CD  LYS A 198      -0.346  -3.015   5.237  1.00 10.37   A
ATOM   6540  CE  LYS A 198      -1.794  -2.809   5.616  1.00 10.74   A
ATOM   6541  NZ  LYS A 198      -2.644  -2.633   4.407  1.00 11.54   A
ATOM   6542  C   LYS A 198       2.996  -1.350   6.203  1.00  7.94   A
ATOM   6543  O   LYS A 198       2.420  -0.263   6.082  1.00  8.01   A
ATOM   6544  N   LEU A 199       3.929  -1.589   7.119  1.00  8.20   A
ATOM   6545  CA  LEU A 199       4.335  -0.592   8.101  1.00  8.16   A
ATOM   6546  CB  LEU A 199       4.199  -1.180   9.510  1.00  8.84   A
ATOM   6547  CG  LEU A 199       2.859  -1.852   9.827  1.00  9.23   A
ATOM   6548  CD1 LEU A 199       2.923  -2.499  11.203  1.00  9.71   A
ATOM   6549  CD2 LEU A 199       1.739  -0.827   9.745  1.00  9.80   A
ATOM   6550  C   LEU A 199       5.775  -0.130   7.882  1.00  8.13   A
ATOM   6551  OT1 LEU A 199       6.440  -0.652   6.959  1.00  7.55   A
ATOM   6552  OT2 LEU A 199       6.216   0.753   8.649  1.00  8.21   A
ATOM   6613  N1  GSH H   4      12.088   5.233  20.820  1.00  7.13   H
ATOM   6614  CA1 GSH H   4      12.962   4.197  20.254  1.00  7.03   H
ATOM   6615  C1  GSH H   4      13.457   4.588  18.834  1.00  6.55   H
ATOM   6616  O11 GSH H   4      12.879   5.504  18.242  1.00  6.42   H
ATOM   6617  O12 GSH H   4      14.524   3.959  18.368  1.00  5.57   H
ATOM   6618  CB1 GSH H   4      12.145   2.885  20.215  1.00  7.92   H
ATOM   6619  CG1 GSH H   4      13.006   1.603  20.044  1.00  8.47   H
ATOM   6620  CD1 GSH H   4      12.022   0.396  19.925  1.00  9.25   H
ATOM   6621  OE1 GSH H   4      11.170   0.182  20.803  1.00  9.64   H
ATOM   6622  N2  GSH H   4      12.250  -0.419  18.881  1.00  9.52   H
ATOM   6623  CA2 GSH H   4      11.428  -1.623  18.662  1.00 10.30   H
ATOM   6624  C2  GSH H   4      12.205  -2.870  19.063  1.00 10.93   H
ATOM   6625  O2  GSH H   4      13.436  -2.897  19.121  1.00  9.41   H
ATOM   6626  CB2 GSH H   4      11.161  -1.836  17.165  1.00 10.45   H
ATOM   6627  SG2 GSH H   4      10.101  -0.583  16.421  1.00 11.44   H
ATOM   6628  N3  GSH H   4      11.453  -3.878  19.521  1.00 12.52   H
ATOM   6629  CA3 GSH H   4      11.906  -5.282  19.488  1.00 13.88   H
ATOM   6630  C3  GSH H   4      12.200  -5.722  20.899  1.00 14.49   H
ATOM   6631  O31 GSH H   4      12.672  -6.865  21.036  1.00 15.15   H
ATOM   6632  O32 GSH H   4      12.014  -4.897  21.826  1.00 15.40   H
ATOM   6675 MG+2 MG2 M 901      10.564  10.708  23.002  1.00  6.47   M
ATOM   6761  C1  HQL X 201       0.783   3.731  14.700  1.00 14.62   X
ATOM   6762  C2  HQL X 201       1.692   4.118  15.845  1.00 14.59   X
ATOM   6763  C3  HQL X 201       3.106   3.797  15.836  1.00 14.55   X
ATOM   6764  C4  HQL X 201       3.711   3.097  14.685  1.00 14.90   X
ATOM   6765  C5  HQL X 201       5.187   2.827  14.734  1.00 15.13   X
ATOM   6766  O1  HQL X 201       5.430   1.582  13.989  1.00 16.49   X
ATOM   6767  C6  HQL X 201       6.385   0.713  14.568  1.00 18.14   X
ATOM   6768  C7  HQL X 201       5.869   0.071  16.022  1.00 18.91   X
ATOM   6769  C8  HQL X 201       5.795  -1.443  16.083  1.00 19.93   X
ATOM   6770  N1  HQL X 201       5.334  -2.091  14.799  1.00 20.61   X
ATOM   6771  C9  HQL X 201       5.405  -3.554  15.187  1.00 21.81   X
ATOM   6772  C10 HQL X 201       5.034  -4.554  14.080  1.00 23.26   X
ATOM   6773  C11 HQL X 201       5.181  -5.967  14.572  1.00 24.56   X
ATOM   6774  C12 HQL X 201       4.877  -6.836  13.391  1.00 25.39   X
ATOM   6775  N2  HQL X 201       3.772  -6.819  12.624  1.00 25.84   X
ATOM   6776  N3  HQL X 201       3.922  -7.729  11.695  1.00 26.13   X
ATOM   6777  N4  HQL X 201       5.093  -8.318  11.859  1.00 26.09   X
ATOM   6778  N5  HQL X 201       5.695  -7.787  12.893  1.00 25.73   X
ATOM   6779  C13 HQL X 201       6.228  -1.740  13.566  1.00 19.90   X
ATOM   6780  C14 HQL X 201       6.591  -0.245  13.299  1.00 18.75   X
ATOM   6781  C15 HQL X 201       5.994   4.025  14.243  1.00 14.57   X
ATOM   6782  C16 HQL X 201       6.642   4.886  15.312  1.00 14.43   X
ATOM   6783  C17 HQL X 201       7.411   6.102  14.925  1.00 14.09   X
ATOM   6784  C18 HQL X 201       7.560   6.480  13.475  1.00 14.22   X
ATOM   6785  C19 HQL X 201       6.931   5.623  12.396  1.00 14.18   X
ATOM   6786  C20 HQL X 201       6.151   4.410  12.778  1.00 14.33   X
ATOM   6787  C21 HQL X 201       2.813   2.674  13.498  1.00 14.91   X
ATOM   6788  C22 HQL X 201       1.353   2.988  13.530  1.00 14.88   X
ATOM   6790  OH2 WAT S   2      14.771   8.489  19.484  1.00  5.47   S
ATOM   6791  OH2 WAT S   3      11.680   1.507   3.580  1.00  5.07   S
ATOM   6794  OH2 WAT S   6      16.764   2.346  18.953  1.00  6.31   S
ATOM   6797  OH2 WAT S   9      10.902   6.761  11.193  1.00  3.72   S
ATOM   6802  OH2 WAT S  14      17.269  -1.249   7.632  1.00  5.08   S
ATOM   6804  OH2 WAT S  16      19.130  -0.458  21.382  1.00  6.03   S
ATOM   6807  OH2 WAT S  19       9.886  -0.690   3.622  1.00  4.46   S
ATOM   6809  OH2 WAT S  21      11.248   7.004  14.090  1.00  4.99   S
ATOM   6814  OH2 WAT S  26      23.738  -1.909  12.157  1.00  5.26   S
ATOM   6818  OH2 WAT S  30      17.625   1.909  21.799  1.00  6.78   S
ATOM   6824  OH2 WAT S  36      16.161   2.164  24.178  1.00  8.59   S
ATOM   6825  OH2 WAT S  37       6.016   5.686   6.917  1.00  8.02   S
ATOM   6834  OH2 WAT S  46       6.979   0.708   2.055  1.00  6.31   S
ATOM   6838  OH2 WAT S  50      12.098   8.108  20.192  1.00  7.43   S
ATOM   6851  OH2 WAT S  63       5.327   2.748   9.978  1.00 10.75   S
ATOM   6862  OH2 WAT S  74       7.157   4.594   9.351  1.00  8.69   S
ATOM   6875  OH2 WAT S  87      13.436   2.712  24.346  1.00 11.43   S
ATOM   6881  OH2 WAT S  93      13.465   2.511  27.281  1.00  8.49   S
ATOM   6917  OH2 WAT S 129       4.790  -5.831   4.947  1.00 16.22   S
ATOM   6923  OH2 WAT S 135      11.522  -7.922   8.942  1.00 14.58   S
ATOM   6927  OH2 WAT S 139       7.332   5.571  25.452  1.00 13.15   S
ATOM   6931  OH2 WAT S 144       4.347   8.725  24.399  1.00 18.59   S
ATOM   6936  OH2 WAT S 149      21.684  -0.730  22.365  1.00 19.24   S
ATOM   6940  OH2 WAT S 153       6.829   6.961   4.592  1.00 11.46   S
ATOM   6994  OH2 WAT S 207       9.472   5.801  21.506  1.00 15.51   S
ATOM   6997  OH2 WAT S 210       5.042  -4.149   7.833  1.00 13.78   S
ATOM   7091  OH2 WAT S 304       3.700   2.599  19.458  1.00 18.38   S
ATOM   7143  OH2 WAT S 356       4.462   6.079  25.441  1.00 21.81   S
ATOM   7153  OH2 WAT S 366      14.674  -8.789   5.088  1.00 25.86   S
ATOM   7162  OH2 WAT S 375      14.316  13.133  20.343  1.00 19.71   S
ATOM   7174  OH2 WAT S 387       8.250   1.189  18.665  1.00 24.62   S
ATOM   7183  OH2 WAT S 396      20.328  -6.928  24.875  1.00 32.42   S
ATOM   7223  OH2 WAT S 436      22.932  -6.039  12.661  1.00 30.30   S
ATOM   7226  OH2 WAT S 439      10.226 -11.668   9.025  1.00 26.07   S
ATOM   7227  OH2 WAT S 440      10.828   1.782  27.468  1.00 17.99   S
ATOM   7231  OH2 WAT S 444      11.916 -14.217  16.326  1.00 26.35   S
ATOM   7244  OH2 WAT S 457      16.265  -1.371  28.167  1.00 34.60   S
ATOM   7281  OH2 WAT S 494       7.021  -5.903   6.732  1.00 25.70   S
ATOM   7290  OH2 WAT S 503      11.401   0.940  23.577  1.00 22.25   S
ATOM   7313  OH2 WAT S 526      15.359   0.458  26.169  1.00 23.29   S
ATOM   7325  OH2 WAT S 538      11.588  -8.884  22.349  1.00 25.83   S
ATOM   7341  OH2 WAT S 554      10.740  -8.906  19.123  1.00 36.43   S
ATOM   7365  OH2 WAT S 578       9.748  -2.511  21.886  1.00 32.74   S
ATOM   7428  OH2 WAT S 641       9.454  12.503  23.240  1.00  7.54   S
ATOM   7429  OH2 WAT S 642       9.887   9.966  24.786  1.00 10.81   S
ATOM   7430  OH2 WAT S 643      12.091  11.779  23.976  1.00 13.97   S
ATOM   7431  OH2 WAT S 644      11.037  11.297  21.097  1.00 12.32   S
ATOM   7432  OH2 WAT S 645       8.928   9.669  22.178  1.00  9.54   S
ATOM   7433  OH2 WAT S 646      11.790   9.079  22.827  1.00  8.22   S
ATOM   7445  OH2 WAT S 658       8.377   3.747  23.391  1.00 28.44   S
ATOM   7448  OH2 WAT S 661      10.331  -0.751  28.752  1.00 36.87   S
ATOM   7449  OH2 WAT S 662      11.270  -5.110  29.771  1.00 27.40   S
ATOM   7473  OH2 WAT S 686       6.297  -7.443   3.798  1.00 34.15   S
ATOM   7482  OH2 WAT S 695       2.766  -7.409   6.323  1.00 31.70   S
ATOM   7483  OH2 WAT S 696       3.236  -5.622   9.446  1.00 30.92   S
ATOM   7490  OH2 WAT S 703       7.547   8.295  24.274  1.00 13.98   S
ATOM   7498  OH2 WAT S 711      23.720   0.535  21.093  1.00 33.19   S
ATOM   7518  OH2 WAT S 731      11.607 -11.967  17.559  1.00 29.38   S
ATOM   7606  OH2 WAT S 819      13.230  -5.747  25.483  1.00 31.58   S
ATOM   7607  OH2 WAT S 820      15.415  -8.549  26.956  1.00 34.91   S
ATOM   7646  OH2 WAT S 859      19.195  -6.110  26.916  1.00 43.51   S
ATOM   7663  OH2 WAT S 876       9.450  -8.128  10.745  1.00 28.17   S
ATOM   7664  OH2 WAT S 877       6.964  -8.045   9.036  1.00 32.76   S
ATOM   7677  OH2 WAT S 890      -4.103  -2.947  14.907  1.00 31.94   S
ATOM   7685  OH2 WAT S 898       0.382  -6.331  13.311  1.00 40.22   S
ATOM   7703  OH2 WAT S 916      12.503 -10.886  20.792  1.00 32.79   S
ATOM   7726  OH2 WAT S 939       9.361   1.904  25.025  1.00 24.74   S
ATOM   7733  OH2 WAT S 946       6.220  10.170  25.032  1.00 33.80   S
ATOM   7801  OH2 WAT S1014       9.686  -9.232   5.261  1.00 31.69   S
ATOM   7802  OH2 WAT S1015       3.009  -1.511  23.142  1.00 36.99   S
ATOM   7825  OH2 WAT S1038      12.443  -8.837  27.155  1.00 37.43   S
ATOM   7836  OH2 WAT S1049       2.595   0.473  29.257  1.00 34.46   S
ATOM   7879  OH2 WAT S1092       8.471  -3.139  15.245  1.00 24.42   S
ATOM   7889  OH2 WAT S1102       8.537  -5.669  15.531  1.00 33.36   S
ATOM   7890  OH2 WAT S1103       9.120  -7.616  16.968  1.00 37.15   S
ATOM   7932  OH2 WAT S1147       2.722   0.246  25.232  1.00 38.87   S
ATOM   7933  OH2 WAT S1148       1.715   2.322  24.218  1.00 34.69   S
ATOM   7946  OH2 WAT S1161      12.929  -1.852  29.410  1.00 40.70   S
ATOM   8049  OH2 WAT S1264       5.506  -4.229  21.028  1.00 36.38   S
ATOM   8050  OH2 WAT S1265       7.355  -0.482  24.373  1.00 39.74   S
ATOM   8051  OH2 WAT S1266       5.564  -1.958  27.066  1.00 38.45   S
ATOM   8054  OH2 WAT S1269       1.047  -2.647  28.146  1.00 39.12   S
【００５５】
【配列表】
0004071477.tif 000016
0004071477.tif 000017
【図面の簡単な説明】
【図１】  ヒト由来プロスタグランジンＤ合成酵素（ＰＧＤＳ）（カルシウム型）とグルタチオンとの複合体の３次元立体構造。ＰＧＤＳはダイマーを形成し、ダイマーの中心に金属イオンサイトがある。
【図２】  ＰＧＤＳのモノマー構造を横から見たもの。
【図３】  図２と全く同じ方位から見たＰＧＤＳの表面構造を示す。
【図４】  カルシウム型ＰＧＤＳ、グルタチオン、及びＵ４６の複合体の表面構造の拡大図である。Ｕ４６のシクロペンタン環の酸素原子は、グルタチオンと水素結合している。
【図５】  カルシウム型ＰＧＤＳ、グルタチオン、及びＵ４４の複合体の立体構造を示す。基質類似物Ｕ４６のα鎖の周りには、塩基性のアミノ酸残基である、Lys107、Lys112、Lys198が取り囲んでおり、α鎖との間に水素結合が見られた。マグネシウム型でもほぼ同様の複合体構造が得られている。
【図６】  マグネシウム型ＰＧＤＳ、グルタチオン、及びＵ４６の複合体の立体構造を示す。
【図１】
0004071477.tif 000018
【図２】
0004071477.tif 000019
【図３】
0004071477.tif 000020
【図４】
0004071477.tif 000021
【図５】
0004071477.tif 000022
【図６】
0004071477.tif 000023