【手続補正書】
【提出日】平成18年5月2日(2006.5.2)
【手続補正１】
【補正対象書類名】明細書
【補正対象項目名】０００５
【補正方法】変更
【補正の内容】
【０００５】
薬剤の半減期および分布を伸ばすため、血清アルブミンへ薬剤をコンジュゲート（ｃｏｎｊｕｇａｔｅ）することも知られている。最近、ＨＳＡ−ＣＤ４およびＨＳＡ−Ｃｕ，Ｚｎ−スーパーオキシドディスムターゼのごときキメラアルブミン分子が、半減期および分布を増加させるため、およびこれらの潜在的タンパク質治療剤の免疫原性を減少させるために、利用されてきた。
【特許文献１】米国特許第６，１７７，５４２号明細書
【特許文献２】米国特許第５，１１６，９４４号明細書
【特許文献３】米国特許第５，２２３，４０９号明細書
【特許文献４】米国特許第５，５３８，８９７号明細書
【特許文献５】米国特許第５，７６７，２４３号明細書
【特許文献６】米国特許第５，７８０，５９４号明細書
【特許文献７】米国特許出願公開第２００２／００１９３５０号明細書
【特許文献８】米国特許出願公開第２００２／０１４６７５０号明細書
【特許文献９】米国特許出願公開第２００２／０１６４６６７号明細書
【特許文献１０】米国特許出願公開第２００２／００１９３５０号明細書
【特許文献１１】米国特許出願公開第２００３／００６９３９５号明細書
【特許文献１２】米国特許出願公開第２００４／０００９５３４号明細書
【特許文献１３】国際公開第００／３７５０１号パンフレット
【特許文献１４】欧州特許出願公開第０３９５９１８号明細書
【特許文献１５】国際公開第９１／０１７４３号パンフレット
【特許文献１６】国際公開第９２／１２２３６号パンフレット
【特許文献１７】国際公開第０３／０７４００５号パンフレット
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【非特許文献２】Arakawa, T. and Kita, Y., “Stabilizing Effects of Caprylate and acetyltryptophanate on Heat-Induced Aggregation of Bovine Serum Albumin”, Biochim. Biophy. Acta, 2000, 1479, p. 32-36
【非特許文献３】Akerstrom et al., “Definition of IgG- and Albumin-binding Regions of Streptococcal Protein G”, Journal of Biological Chemistry, 1987, 262 (28), p. 13388-13391
【非特許文献４】Burger et al., “Pre-Clinical Evaluation of a Methotrexate-Albumin Conjugate (MTX-HSA) in Human Tumor Xenografts in vivo”, International Journal of Cancer, 2001, 92, p. 718-724
【非特許文献５】Chhabra et al., “Appraisal of New Variants of Dde Amine Protecting Group for Solid Phase Peptide Synthesis”, Tetrahedron Lett., 1998, 39, p. 1603-1606
【非特許文献６】Cheruvallath, V. et al., “The Effect of Octanoic Acid on the Binding of the Enantiomers of Ibuprofen and Naproxen to Human Serum Albumin:  A Chromatographic Implication”, Pharm. Res., 1996, 13, p. 173-178
【非特許文献７】Hollon, T., “HGS Targets Patent-Expiring Drugs”, Nat. Biotechnol., 2000, 28, p. 1238-1239
【非特許文献８】Kobayashi, K. et al., “The Developmentl of Recombinant Human Serum Albumin”, Ther. Apher, 1998, 2, p. 257-262
【非特許文献９】Kragh-Hansen, U., “Octanoate Binding to the Indole- and Benzodiazepine Binding Region of Human Serum Albumin”, Biochem. J., 1991, 273, p. 641-644
【非特許文献１０】Luik, A. et al., “Study of Human Serum Albumin Structure by Dynamic Light Scattering: Two Types of Reactions Under Different pH and Interaction with Physiologically Active Compounds”, Spectrochim. Acta. Part A, 1998, 54, p. 1503-1507
【非特許文献１１】Mahany, T. et al., “Studies on the Affinity Chromatography of Serum Albumins from Human and Animal Plasmas”, Camp. Biochem. Physiol., 1981, 68B, p. 319-323
【非特許文献１２】Merrifield, R., “Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide”, J. Am. Chem. Sot., 1963, 85, p. 2149-2154
【非特許文献１３】Norde, W. and Giacomelli, C., “BSA Structural Changes During Homomolecular Exchange Between the Adsorbed and the Dissolved States”, J. Biotechnol., 2000, 79, p. 259-268
【非特許文献１４】Pingali, A. et al., “Peptides as Affinity Surfaces for Protein Purification”, J. Mol. Recognit., 1996, 9, p. 426-432
【非特許文献１５】Ross, P. et al., “Thermal Stability of Human Albumin Measured by Differential Scanning Calorimetry”, Vox Sang, 1984, 47, p. 19-27
【非特許文献１６】Saeed, M. et al., “Blood Pool MR Contrast Agents for Cardiovascular Imaging”, J. Magn. Reson. Imaging, 2000, 12, p. 890-898
【非特許文献１７】Sato et al., “Development of Mammalian Serum Albumin Affinity Purification Media by Phage Display”, Biotechnol. Prog., 2002, 18, p. 182-192
【非特許文献１８】Seabold, J., “Radionuclide Venography and Labeled Platelets in Deep Venous Thrombosis”, Semin. Nucl. Med., 2001, 31, p. 124-128
【非特許文献１９】Shani, M. et al., “Expression of Human Serum Albumin in the Milk of Transgenic Mice”, Transgenic Res., 1992, 1, p. 195-208
【非特許文献２０】Shrake, A. et al., “Thermanl Stability of Human Albumin Measured by Differential Scanning Calorimetry”, Vox Sang., 1984, 47, p. 7-18
【非特許文献２１】Sijmons, P. et al., “Production of Correctly Processed Human Serum Albumin in Transgenic Plants”, Biotechnology, 1990, 8, p. 217-221
【非特許文献２２】Szekerke, M. et al., “A New Approach to the Study of the Contribution of Peptide Carriers to Antitumor Actibity: Binding of the Peptide Moiety to Human Serum Albumin”, FEBS Letters, 1974, 44, p. 160-163
【非特許文献２３】Yeh, P. et al., “Design of Yeast-Secreted Albumin Derivatives for Human Therapy: Biological and Antiviral Properties of a Serum Albumin-CD4 Genetic Conjugate”, Proc Natl. Acad. Sci. USA, 1992, 89, p. 1904-1908
【非特許文献２４】Yousif et al., “Staphylococcal Neutral Phosphatase: A Highly Catatonic Molecule with Binding Properties for Immunoglobulin”, APMIS, 1994, 102, p. 891-900
【非特許文献２５】Venerando et al., “Interactions of Ganglioside GMI with Human and Fetal Calf Sera Formation of Ganglioside-Serum Albumin Complexes”, Biochimica et Biophysica Acta, 1982, 692, p. 18-26