【手続補正書】
【提出日】平成17年9月9日(2005.9.9)
【手続補正１】
【補正対象書類名】明細書
【補正対象項目名】０１６４
【補正方法】変更
【補正の内容】
【０１６４】
その他の態様
本明細書で言及したすべての出版物および特許出願は、個々の独立した出版物または特許出願が、具体的および個別に参照として組み入れられる同じ程度で参照として本明細書に組み入れられる。本発明は、本発明の特定の態様について記載されているが、さらなる変更が可能であることが理解され、またこの出願は、一般に、本発明の原理に従う、本発明の任意の変形形態、使用、または応用を含むことを意図し、本発明が関する当技術分野の既知の実行法または慣行に含まれる本発明の開示からの逸脱が含まれ、また、上文に記載された本質的特徴に応用されうることが理解され、添付の特許請求の範囲に従う。
【図面の簡単な説明】
【図１】  前立腺特異的なcDNAライブラリーの複数のクローンの例示的なリバースノーザン分析を示す。
【図２】  複数の組織の例示的なノーザンブロットを示す。
【図３】  前立腺組織およびLNCaP細胞から単離された12個のクローンのヌクレオチド配列（配列番号：1〜12）を示す表である。
【図４Ａ】  STMP1遺伝子の構造を示す略図である。
【図４Ｂ】  STMP1のイントロン境界配列を含むヌクレオチド配列（配列番号：13）、および推定アミノ酸配列（配列番号：14）を示す。
【図４Ｃ】  STMP1のエキソンおよび3'UTRのヌクレオチド配列を示す（配列番号：15〜21）。
【図４Ｄ】  STMP1のORFのヌクレオチド配列を示す（配列番号：22）。
【図４Ｅ】  STMP1のcDNA配列（配列番号：23）、および推定アミノ酸配列（配列番号：14）を示す。
【図４Ｆ】  STMP1 ORF2のエキソンおよび3'UTRのヌクレオチド配列（配列番号：17〜20および24〜26）を示す。
【図４Ｇ】  STMP1 ORF2のORFのヌクレオチド配列（配列番号：27）を示す。
【図４Ｈ】  STMP1 ORF2のcDNA配列（配列番号：28）、および推定アミノ酸配列（配列番号：29）を示す。
【図４Ｉ】  STMP1 ORF3のエキソンおよび3'UTRのヌクレオチド配列（配列番号：17〜19および24〜26）を示す。
【図４Ｊ】  STMP1 ORF3のORFのヌクレオチド配列（配列番号：30）を示す。
【図４Ｋ】  STMP1 ORF3のcDNA配列（配列番号：31）、および推定アミノ酸配列（配列番号：32）を示す。
【図４Ｌ】  STMP2のcDNA配列（配列番号：33）、および推定アミノ酸配列（配列番号：34）を示す。
【図４Ｍ】  STMP3のcDNA配列（配列番号：35）、および推定アミノ酸配列（配列番号：36）を示す。
【図５】  STMP1（配列番号：14）の配列とSTEAP（配列番号：37、アクセッション番号AF186249）、および2つのEST（アクセッション番号BAA91839およびBAB15559；それぞれ配列番号：38および39）との配列アラインメントを示す。
【図６】  図6Aは、STMP1またはG3PDHのcDNAをプローブとして、複数の組織のノーザンブロットを示す。図6Bは、アンドロゲン応答性の前立腺癌細胞系LNCaP、およびCWR22ヒト前立腺癌異種移植片モデルにおける、STMP1およびPSAをプローブとしたノーザンブロットである。図6Cは、LNCaP、PC-3、およびDU-145の細胞系、ならびにCWR22Rヒト前立腺癌異種移植片モデルにおける、STMP1およびNKX3Aをプローブとしたノーザンブロットである。
【図７Ａ】  GFP-STMP1で一過的にトランスフェクトしたCOS-1細胞の蛍光顕微鏡画像を示す。
【図７Ｂ】  GFP-STMP1で一過的にトランスフェクトし、ゴルジマーカーに対する抗体で標識したCOS-1細胞の蛍光顕微鏡画像を示す。
【図８】  GFP-STMP1で一過的にトランスフェクトし、生細胞を共焦点顕微鏡で観察したCOS-1細胞の蛍光顕微鏡画像を示す。
【図９】  GFP-STMP1で一過的にトランスフェクトし、初期エンドソームマーカーに対する抗体で標識したCOS-1細胞の蛍光顕微鏡画像を示す。
【図１０】  SSH9遺伝子の構造およびSSH9遺伝子から転写された2種のmRNAを示す略図である。
【図１１Ａ】  SSH9のcDNA（配列番号：40）および推定アミノ酸配列（配列番号：41）を示す。
【図１１Ｂ】  SSH9の推定プロモーター配列（配列番号：42）を示す。
【図１１Ｃ】  SSH9の推定イントロン-エキソン境界（配列番号：43〜50）を示す。
【図１２】  図12Aは、アンドロゲン応答性の前立腺癌細胞系LNCaP細胞において、およびCWR22ヒト前立腺癌異種移植片モデルにおいて、SSH9をプローブとしたノーザンブロットである。図12Bは、LNCaP、PC-3、およびDU-145の細胞系、ならびにCWR22Rヒト前立腺癌異種移植片モデルにおいて、SSH9をプローブとしたノーザンブロットである。図12Cは、SSH9またはGAPDHのcDNAをプローブとした、複数の組織のノーザンブロットである。
【図１３】  PSL22遺伝子構造を示す略図である。
【図１４Ａ】  PSL22のORFのヌクレオチド配列（配列番号：51）を示す。
【図１４Ｂ】  PSL22のcDNA配列（配列番号：52）および推定アミノ酸配列（配列番号：53）を示す。
【図１４Ｃ】  PSL22のTATAプロモーターおよび転写開始部位、エキソン、ならびに5'および3'のUTRのヌクレオチド配列を示す（配列番号：54〜70）。
【図１５】  PSL22（RhoBP）（配列番号：53）の、EST NP032190（mRhoph）、AF132025（dRhoph）、およびBAB23615（配列番号：71〜73）との配列アラインメントを示す。
【図１６】  図１６Ａは、LNCaP、PC-3、およびDU-145細胞系、ならびにCWR22R ヒト前立腺癌異種移植片モデルにおける、PSL22をプローブとしたノーザンブロットである。図１６Ｂは、PSL22のcDNAをプローブとした、複数の組織のノーザンブロットである。
【配列表】
SEQUENCE LISTING
<110> SAATCIOGLU, FAHRI
<120> NOVEL PROSTATE-SPECIFIC OR TESTIS-SPECIFIC 
NUCLEIC ACID MOLECULES, POLYPEPTIDES, AND
DIAGNOSTIC AND THERAPEUTIC METHODS
<130> CE-A0228
<140> JP 2001-571877     
<141> 2001-03-23  
<150> US 60/191,929       
<151> 2000-03-24  
<160> 73
<170> FastSEQ for Windows Version 4.0
<210> 1
<211> 349
<212> DNA
<213> Homo sapiens
<400> 1
actaatgtga ggaaacaaac atgttcaggc ctgaacattt ccggtgctga ctcggcctta 60
aacgtttgtg ccataatgga aaatatctat ctatctgttc tcaaatcctg tttttctcat 120
agtgtaaact cacatttgat gtgtttttat gaaggaaagt aaccaagaaa cctctaggaa 180
ttaggaaaaa aagaactttt ttgaggtgtg ttactatact gctgtaagtt atttattata 240
taaagtattg taaatagaaa tagtgttgag atatgaaata tggctatttt taatggtgac 300
aattatagac ttttaggtca ctattaaatt ggggttacct atatccagt             349
<210> 2
<211> 251
<212> DNA
<213> Homo sapiens
<400> 2
acacatccat cattgtgaaa tctcttttcc aacaaacgtc ctcttaatga gcacaattca 60
ttaaaatctt tggggactaa gctacgaaca aagttcaact aaactaccta ctgacttcaa 120
aaggaacata tacccaccac gtgtggtagc tcatgactgt aatcccagca ctttgggagg 180
ctgaggcagg aggatcacct gagcccagga gttccagacc agcctaagca acatgccaag 240
accctgtatg t                                                      251
<210> 3
<211> 51
<212> DNA
<213> Homo sapiens
<400> 3
acaaagacac ccttgtyccc cgggcaaggt cctccagcta caagggggcc a          51
<210> 4
<211> 149
<212> DNA
<213> Homo sapiens
<220> 
<221> misc_feature   
<222> 3
<223> n = A,T,C or G
<400> 4
ccnyacattg tcacagagag gctccaggct taaagttgac ctgcgtagaa agcaagaatg 60
aattgttgga ggaagtaagg agggcgattg aataaagact tttagcagct gggccagctg 120
aaccatccca acccttcaaa tccccttgt                                   149
<210> 5
<211> 261
<212> DNA
<213> Homo sapiens
<400> 5
accctaactg aacccatttc agccactcag attgataggg tggaaaagac agggcaggtg 60
gtagcagctg tgaagaaaag aggaaagcag aagggtggcc tataatctac aggcatgtag 120
agaggactac ataggcctct gttctttgcc ctcaggagcc cccttcctgt cccttggact 180
cagaatggat ccttccagca cacatggccc aacactgaga gtgcaggaag catgggtagg 240
ggcctcctgc tgctggtatg t                                           261
<210> 6
<211> 121
<212> DNA
<213> Homo sapiens
<220> 
<221> misc_feature   
<222> 4, 7, 13, 22, 24, 29, 30, 34, 36, 40, 46, 111, 112
<223> n = A,T,C or G
<400> 6
agtntgnggg ganttgaggg cngntacgnn aaangntggn ctactntaga tgctgctcga 60
gcggccgcca gtgtgatgga tacaagcttt cttttttttt tttattttcg nntttttttt 120
c                                                                 121
<210> 7
<211> 93
<212> DNA
<213> Homo sapiens
<400> 7
actcagtagg gactgagcac taaatgctta ttttaaaaga aatgtaaaga gcagaaagca 60
attcaggcta ccctgccttt tgtgctggct agt                              93
<210> 8
<211> 169
<212> DNA
<213> Homo sapiens
<400> 8
acacttaaaa tagttaatgt gatacatttt atgttacatg tattttgccc actgaaaaaa 60
taaaaatata taaacacaca gcaaatgatg accaggcctt tgaagaaagc ttataaaaca 120
aaattaagaa gcctggctac agagcgagac tctgtctcaa aaaaaaaaa             169
<210> 9
<211> 262
<212> DNA
<213> Homo sapiens
<400> 9
actttacaag catgaaggat attagggtaa gtggctaatt ataaatctac tctagagaca 60
tataatcata cagattattc ataaaatttt tcagtgctgt ccttccacat ttaattgcat 120
tttgctcaaa ctgtagaatg ccctacattc cccccacccc aatttgctat ttccttatta 180
aaatagaaaa ttataggcaa gatacaatta tatgcgttcc tcttcctgaa attataacat 240
ttctaaactt acccacgtag gt                                          262
<210> 10
<211> 175
<212> DNA
<213> Homo sapiens
<400> 10
acaggttggc ccttcaccta gttgactcag ccctcgatag tctagagccc accccctcct 60
caggaactca agagctcagc atttataatg agcagttggt aatgagttgc cctatgtgct 120
tgtcgcaagc agtcacagag atgagcccta ttacttgata ttcaggaaca aaggt      175
<210> 11
<211> 331
<212> DNA
<213> Homo sapiens
<400> 11
acatccaagc cttcctctgc gtgagagcaa aggctttgct catcagccag ccagtcttgt 60
tactatctgg ctacttttta aggttaaaaa ataaaaggca gtttctttgc tctgcaggcg 120
gcaaggcagg aggcgcaggc ctcttcattg ttcacatgtc acaggaggag gctctgagca 180
aaggccactg gcaagttagg gcaacaccaa gaaggctctg cggagagact ccctgtgggt 240
tgggggsctg gcaggaacgg tgcctgtgga ctgtttatgg tctgtccagt tgaggcttgg 300
taaacccaag taaagtgtta aaaacctcag t                                331
<210> 12
<211> 170
<212> DNA
<213> Homo sapiens
<400> 12
acgactcatc cacctccggc tgaagctcca ggagctgaag gaccccaatg aggatgagcc 60
aaacatccga gtgctccttg agcaccgctt ttacaaggag aagagcaaga gcgtcaagca 120
gacctgtgac aagtgtaaca ccatcatctg ggggctcatt cagacctggt            170
<210> 13
<211> 1720
<212> DNA
<213> Homo sapiens
<400> 13
acgcggggga tccagcttgg gtaggcgggg aagcagctgg agtgcgaccg ctacggcagc 60
caccctgcaa ccgccagtcg gaggtgcact agagctaagg gcaagtcctg aggttgggcc 120
caggagaaag aaggcaagga gacattgtcc caggtaggat ctaggatatt cttggtgatc 180
ttggaagtgt ccgtatcatg gaatcaatct ctatgatggg aagccctaag agccttagtg 240
aaacttgttt acctaatggc ataaatggta tcaaagatgc aaggaaggtc actgtaggtg 300
tgattggaag tggagatttt gccaaatcct tgaccattcg acttattaga tgcggctatc 360
atgtggtcat aggaagtaga aatcctaagt ttgcttctga attttttcct catgtggtag 420
atgtcactca tcatgaagat gctctcacaa aaacaaatat aatatttgtt gctatacaca 480
gagaacatta tacctccctg tgggacctga gacatctgct tgtgggtaaa atcctgattg 540
atgtgagcaa taacatgagg ataaaccagt acccagaatc caatgctgaa tatttggctt 600
cattattccc agattctttg attgtcaaag gatttaatgt tgtctcagct tgggcacttc 660
agttaggacc taaggatgcc agccggcagg tatgacaggt ttatatatgc agcaacaata 720
ttcaagcgcg acaacaggtt attgaacttg cccgccagtt gaatttcatt cccattgact 780
tgggatcctt atcatcagcc agagagattg aaaatttacc cctacgactc tttactttct 840
ggagagggcc agtggtggta gctataagct tggccacatt ttttttcctt tattcctttg 900
tcagagatgt gattcatcca tatgctagaa accaacagag tgacttttac aaaattccta 960
tagagattgt gaataaaacc ttacctatag ttgccattac tttgctctcc ctagtatacc 1020
ttgcaggtct tctggcagct gcttatcaac tttattacgg caccaagtat aggagatttc 1080
caccttggtt ggaaacctgg ttacagtgta gaaaacagct tggattacta agttttttct 1140
tcgctatggt ccatgttgcc tacagcctct gcttaccgat gagaaggtca gagagatatt 1200
tgtttctcaa catggcttat cagcaggtac tttaggttca tgcaaatatt gaaaactctt 1260
ggaatgagga agaagtttgg agaattgaaa tgtatatctc ctttggcata atgagccttg 1320
gcttactttc cctcctggca gtcacttcta tcccttcagt gagcaatgcc ttaaactgga 1380
gagaattcag ttttattcag gtatgccaat ctacacttgg atatgtcgct ctgctcataa 1440
gtactttcca tgttttaatt tatggatgga aacgagcttt tgaggaagag tactacagat 1500
tttatacacc accaaacttt gttcttgctc ttgttttgcc ctcaattgta attctgggta 1560
agattatttt attccttcca tgtataagcc gaaagctaaa acgaattaaa aaaggctggg 1620
aaaagagcca atttctggaa gaaggtattg gaggaacaat tcctcatgtc tccccggaga 1680
gggtcacagt aatgtgatga taaatggtgt tcacagctgc                       1720
<210> 14
<211> 490
<212> PRT
<213> Homo sapiens
<400> 14
Met Glu Ser Ile Ser Met Met Gly Ser Pro Lys Ser Leu Ser Glu Thr
1               5                  10                  15      
Cys Leu Pro Asn Gly Ile Asn Gly Ile Lys Asp Ala Arg Lys Val Thr
20                  25                  30          
Val Gly Val Ile Gly Ser Gly Asp Phe Ala Lys Ser Leu Thr Ile Arg
35                  40                  45              
Leu Ile Arg Cys Gly Tyr His Val Val Ile Gly Ser Arg Asn Pro Lys
50                  55                  60                  
Phe Ala Ser Glu Phe Phe Pro His Val Val Asp Val Thr His His Glu
65                  70                  75                  80  
Asp Ala Leu Thr Lys Thr Asn Ile Ile Phe Val Ala Ile His Arg Glu
85                  90                  95      
His Tyr Thr Ser Leu Trp Asp Leu Arg His Leu Leu Val Gly Lys Ile
100                 105                 110         
Leu Ile Asp Val Ser Asn Asn Met Arg Ile Asn Gln Tyr Pro Glu Ser
115                 120                 125             
Asn Ala Glu Tyr Leu Ala Ser Leu Phe Pro Asp Ser Leu Ile Val Lys
130                 135                 140                 
Gly Phe Asn Val Val Ser Ala Trp Ala Leu Gln Leu Gly Pro Lys Asp
145                 150                 155                 160 
Ala Ser Arg Gln Val Tyr Ile Cys Ser Asn Asn Ile Gln Ala Arg Gln
165                 170                 175     
Gln Val Ile Glu Leu Ala Arg Gln Leu Asn Phe Ile Pro Ile Asp Leu
180                 185                 190         
Gly Ser Leu Ser Ser Ala Arg Glu Ile Glu Asn Leu Pro Leu Arg Leu
195                 200                 205             
Phe Thr Phe Trp Arg Gly Pro Val Val Val Ala Ile Ser Leu Ala Thr
210                 215                 220                 
Phe Phe Phe Leu Tyr Ser Phe Val Arg Asp Val Ile His Pro Tyr Ala
225                 230                 235                 240 
Arg Asn Gln Gln Ser Asp Phe Tyr Lys Ile Pro Ile Glu Ile Val Asn
245                 250                 255     
Lys Thr Leu Pro Ile Val Ala Ile Thr Leu Leu Ser Leu Val Tyr Leu
260                 265                 270         
Ala Gly Leu Leu Ala Ala Ala Tyr Gln Leu Tyr Tyr Gly Thr Lys Tyr
275                 280                 285             
Arg Arg Phe Pro Pro Trp Leu Glu Thr Trp Leu Gln Cys Arg Lys Gln
290                 295                 300                 
Leu Gly Leu Leu Ser Phe Phe Phe Ala Met Val His Val Ala Tyr Ser
305                 310                 315                 320 
Leu Cys Leu Pro Met Arg Arg Ser Glu Arg Tyr Leu Phe Leu Asn Met
325                 330                 335     
Ala Tyr Gln Gln Val His Ala Asn Ile Glu Asn Ser Trp Asn Glu Glu
340                 345                 350         
Glu Val Trp Arg Ile Glu Met Tyr Ile Ser Phe Gly Ile Met Ser Leu
355                 360                 365             
Gly Leu Leu Ser Leu Leu Ala Val Thr Ser Ile Pro Ser Val Ser Asn
370                 375                 380                 
Ala Leu Asn Trp Arg Glu Phe Ser Phe Ile Gln Ser Thr Leu Gly Tyr
385                 390                 395                 400 
Val Ala Leu Leu Ile Ser Thr Phe His Val Leu Ile Tyr Gly Trp Lys
405                 410                 415     
Arg Ala Phe Glu Glu Glu Tyr Tyr Arg Phe Tyr Thr Pro Pro Asn Phe
420                 425                 430         
Val Leu Ala Leu Val Leu Pro Ser Ile Val Ile Leu Gly Lys Ile Ile
435                 440                 445             
Leu Phe Leu Pro Cys Ile Ser Arg Lys Leu Lys Arg Ile Lys Lys Gly
450                 455                 460                 
Trp Glu Lys Ser Gln Phe Leu Glu Glu Gly Ile Gly Gly Thr Ile Pro
465                 470                 475                 480 
His Val Ser Pro Glu Arg Val Thr Val Met
485                 490 
<210> 15
<211> 83
<212> DNA
<213> Homo sapiens
<400> 15
acgcggggga tccagcttgg gtaggcgggg aagcagctgg agtgcgaccg ctacggcagc 60
caccctgcaa ccgccagtcg gag                                         83
<210> 16
<211> 61
<212> DNA
<213> Homo sapiens
<400> 16
agctaagggc aagtcctgag gttgggccca ggagaaagaa ggcaaggaga cattgtccca 60
g                                                                 61
<210> 17
<211> 525
<212> DNA
<213> Homo sapiens
<400> 17
gatattcttg gtgatcttgg aagtgtccgt atcatggaat caatctctat gatgggaagc 60
cctaagagcc ttagtgaaac ttttttacct aatggcataa atggtatcaa agatgcaagg 120
aaggtcactg taggtgtgat tggaagtgga gattttgcca aatccttgac cattcgactt 180
attagatgcg gctatcatgt ggtcatagga agtagaaatc ctaagtttgc ttctgaattt 240
tttcctcatg tggtagatgt cactcatcat gaagatgctc tcacaaaaac aaatataata 300
tttgttgcta tacacagaga acattatacc tccctgtggg acctgagaca tctgcttgtg 360
ggtaaaatcc tgattgatgt gagcaataac atgaggataa accagtaccc agaatccaat 420
gctgaatatt tggcttcatt attcccagat tctttgattg tcaaaggatt taatgttgtc 480
tcagcttggg cacttcagtt aggacctaag gatgccagcc ggcag                 525
<210> 18
<211> 528
<212> DNA
<213> Homo sapiens
<400> 18
gtttatatat gcagcaacaa tattcaagcg cgacaacagg ttattgaact tgcccgccag 60
ttgaatttca ttcccattga cttgggatcc ttatcatcag ccagagagat tgaaaattta 120
cccctacgac tctttactct ctggagaggg ccagtggtgg tagctataag cttggccaca 180
ttttttttcc tttattcctt tgtcagagat gtgattcatc catatgctag aaaccaacag 240
agtgactttt acaaaattcc tatagagatt gtgaataaaa ccttacctat agttgccatt 300
actttgctct ccctagtata cctcgcaggt cttctggcag ctgcttatca actttattac 360
ggcaccaagt ataggagatt tccaccttgg ttggaaacct ggttacagtg tagaaaacag 420
cttggattac taagtttttt cttcgctatg gtccatgttg cctacagcct ctgcttaccg 480
atgagaaggt cagagagata tttgtttctc aacatggctt atcagcag              528
<210> 19
<211> 165
<212> DNA
<213> Homo sapiens
<400> 19
gttcatgcaa atattgaaaa ctcttggaat gaggaagaag tttggagaat tgaaatgtat 60
atctcctttg gcataatgag ccttggctta ctttccctcc tggcagtcac ttctatccct 120
tcagtgagca atgctttaaa ctggagagaa ttcagtttta ttcag                 165
<210> 20
<211> 148
<212> DNA
<213> Homo sapiens
<400> 20
tctacacttg gatatgtcgc tctgctcata agtactttcc atgttttaat ttatggatgg 60
aaacgagctt ttgaggaaga gtactacaga ttttatacac caccaaactt tgttcttgct 120
cttgttttgc cctcaattgt aattctgg                                    148
<210> 21
<211> 2381
<212> DNA
<213> Homo sapiens
<400> 21
gtaagattat tttattcctt ccatgtataa gccgaaagct aaaacgaatt aaaaaaggct 60
gggaaaagag ccaatttctg gaagaaggta ttggaggaac aattcctcat gtctccccgg 120
agagggtcac agtaatgtga tgataaatgg tgttcacagc tgccatataa agttctactc 180
atgccattat ttttatgact tctacgttca gttacaagta tgctgtcaaa ttatcgtggg 240
ttgaaacttg ttaaatgaga tttcaactga cttagtgata gagttttctt caagttaatt 300
ttcacaaatg tcatgtttgc caatatgaat ttttctagtc aacatattat tgtaatttag 360
gtatgttttg ttttgttttg cacaactgta accctgttgt tactttatat ttcataatca 420
gacaaaaata cttacagtta ataatataga tataatgtta aaaacaattt gcaaaccagc 480
agaattttaa gcttttaaaa taattcaatg gatatacatt tttttctgaa gattaagatt 540
ttaattattc aacttaaaaa gtagaaatgc attattatac atttttttaa gaaaggacac 600
gttatgttag catctaggta aggctgcatg atagcattcc tatatttctc tcataaaata 660
ggatttgaag gatgaaatta attgtatgaa gcaatgtgat tatatgaaga gacacaaatt 720
aaaaagacaa attaaacctg aaattatatt taaaatatat ttgagacatg aaatacatac 780
tgataataca tacctcatga aagattttat tctttattgt gttacagagc agtttcattt 840
tcatattaat atactgatca ggaagaggat tcagtaacat ttggcttcca aaactgctat 900
ctctaatacg gtaccaatcc taggaactgt atactagttc ctacttagaa caaaagtatc 960
aagtttgcac acaagtaatc tgccagctga cctttgtcgc accttaacca gtcaccactt 1020
gctatggtat aggattatac tgatgttctt tgagggattc tgatgtgcta ggcatggttc 1080
taagtacttt acttgtatta tcccatttaa tacttagaac aaccccgtga gataagtagt 1140
tattatcctc attttacaca tgagggaccg aaggatagaa aagttatttt tcaaaggtct 1200
tgcagttaat aaatggcaga gtgagcattc aagtccaggt agtcatattc cagaggccac 1260
ggttttaacc actaggctct agagctcccg ccgcgcccct atgcattatg ttcacaatgc 1320
caatctagat gcttcctctt ttgtataaag tcactgacat tctttagagt gggttgggtg 1380
catccaaaaa tgtataaaaa tattattata ataaacttat tactgcttgt agggtaattc 1440
acagttactt accctattct tgcttggaac atgagcctgg agacccatgg cagtccatat 1500
gcctccctat gcagtgaagg gccctagcag tgttaacaaa ttgctgagat cccacggagt 1560
ctttcaaaaa tctctgtaga gttagtcttc tccttttctc ttcctgagaa gttctcctgc 1620
ctgcataacc attcattagg gagtacttta caagcatgaa ggatattagg gtaagtggct 1680
aattataaat ctactctaga gacatataat catacagatt attcataaaa tttttcagtg 1740
ctgtccttcc acatttaatt gcattttgct caaactgtag aatgccctac attcccccca 1800
ccccaatttg ctatttcctt attaaaatag aaaattatag gcaagataca attatatgcg 1860
ttcctcttcc tgaaattata acatttctaa acttacccac gtagggacta ctgaatccaa 1920
ctgccaacaa taaaaagact tttatttagt agaggctacc tttcccccca gtgactcttt 1980
ttctacaact gccttgtcag tttggtaatt cacttatgat tttctaatgt tctcttggtg 2040
aattttatta tcttggaccc tctttttttt tttttttaaa gacagagtct tgctctgtca 2100
cccattgctc tcgtttgggc aacaagagtg aaactcttgt ctcaaaaaaa aaaaaaaatg 2160
aggtttaaga cagttttgtc attactggtg ggatctggtc acacaagata gcattaaacg 2220
tgacatggca cataaaattg gttaaaaaat tttgtttttt aattgcgtaa tgtaaaagcc 2280
caacaaacac tttatgcaag attggaatgt atcttcaaat tcagatttaa taaacatgta 2340
aagatcctct gtaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                     2381
<210> 22
<211> 4329
<212> DNA
<213> Homo sapiens
<400> 22
acgcggggga tccagcttgg gtaggcgggg aagcagctgg agtgcgaccg ctacggcagc 60
caccctgcaa ccgccagtcg gagagctaag ggcaagtcct gaggttgggc ccaggagaaa 120
gaaggcaagg agacattgtc ccaggatatt cttggtgatc ttggaagtgt ccgtatcatg 180
gaatcaatct ctatgatggg aagccctaag agccttagtg aaacttgttt acctaatggc 240
ataaatggta tcaaagatgc aaggaaggtc actgtaggtg tgattggaag tggagatttt 300
gccaaatcct tgaccattcg acttattaga tgcggctatc atgtggtcat aggaagtaga 360
aatcctaagt ttgcttctga attttttcct catgtggtag atgtcactca tcatgaagat 420
gctctcacaa aaacaaatat aatatttgtt gctatacaca gagaacatta tacctccctg 480
tgggacctga gacatctgct tgtgggtaaa atcctgattg atgtgagcaa taacatgagg 540
ataaaccagt acccagaatc caatgctgaa tatttggctt cattattccc agattctttg 600
attgtcaaag gatttaatgt tgtctcagct tgggcacttc agttaggacc taaggatgcc 660
agccggcagg tttatatatg cagcaacaat attcaagcgc gacaacaggt tattgaactt 720
gcccgccagt tgaatttcat tcccattgac ttgggatcct tatcatcagc cagagagatt 780
gaaaatttac ccctacgact ctttactttc tggagagggc cagtggtggt agctataagc 840
ttggccacat tttttttcct ttattccttt gtcagagatg tgattcatcc atatgctaga 900
aaccaacaga gtgactttta caaaattcct atagagattg tgaataaaac cttacctata 960
gttgccatta ctttgctctc cctagtatac cttgcaggtc ttctggcagc tgcttatcaa 1020
ctttattacg gcaccaagta taggagattt ccaccttggt tggaaacctg gttacagtgt 1080
agaaaacagc ttggattact aagttttttc ttcgctatgg tccatgttgc ctacagcctc 1140
tgcttaccga tgagaaggtc agagagatat ttgtttctca acatggctta tcagcaggtt 1200
catgcaaata ttgaaaactc ttggaatgag gaagaagttt ggagaattga aatgtatatc 1260
tcctttggca taatgagcct tggcttactt tccctcctgg cagtcacttc tatcccttca 1320
gtgagcaatg ccttaaactg gagagaattc agttttattc agtctacact tggatatgtc 1380
gctctgctca taagtacttt ccatgtttta atttatggat ggaaacgagc ttttgaggaa 1440
gagtactaca gattttatac accaccaaac tttgttcttg ctcttgtttt gccctcaatt 1500
gtaattctgg gtaagattat tttattcctt ccatgtataa gccgaaagct aaaacgaatt 1560
aaaaaaggct gggaaaagag ccaatttctg gaagaaggta ttggaggaac aattcctcat 1620
gtctccccgg agagggtcac agtaatgtga tgataaatgg tgttcacagc tgccatataa 1680
agttctactc atgccattat ttttatgact tctacgttca gttacaagta tgctgtcaaa 1740
ttatcgtggg ttgaaacttg ttaaatgaga tttcaactga cttagtgata gagttttctt 1800
caagttaatt ttcacaaatg tcatgtttgc caatatgaat ttttctagtc aacatattat 1860
tgtaatttag gtatgttttg ttttgttttg cacaactgta accctgttgt tactttatat 1920
ttcataatca gacaaaaata cttacagtta ataatataga tataatgtta aaaacaattt 1980
gcaaaccagc agaattttaa gcttttaaaa taattcaatg gatatacatt tttttctgaa 2040
gattaagatt ttaattattc aacttaaaaa gtagaaatgc attattatac atttttttaa 2100
gaaaggacac gttatgttag catctaggta aggctgcatg atagcattcc tatatttctc 2160
tcataaaata ggatttgaag gatgaaatta attgtatgaa gcaatgtgat tatatgaaga 2220
gacacaaatt aaaaagacaa attaaacctg aaattatatt taaaatatat ttgagacatg 2280
aaatacatac tgataataca tacctcatga aagattttat tctttattgt gttacagagc 2340
agtttcattt tcatattaat atactgatca ggaagaggat tcagtaacat ttggcttcca 2400
aaactgctat ctctaatacg gtaccaatcc taggaactgt atactagttc ctacttagaa 2460
caaaagtatc aagtttgcac acaagtaatc tgccagctga cctttgtcgc accttaacca 2520
gtcaccactt gctatggtat aggattatac tgatgttctt tgagggattc tgatgtgcta 2580
ggcatggttc taagtacttt acttgtatta tcccatttaa tacttagaac aaccccgtga 2640
gataagtagt tattatcctc attttacaca tgagggaccg aaggatagaa aagttatttt 2700
tcaaaggtct tgcagttaat aaatggcaga gtgagcattc aagtccaggt agtcatattc 2760
cagaggccac ggttttaacc actaggctct agagctcccg ccgcgcccct atgcattatg 2820
ttcacaatgc caatctagat gcttcctctt ttgtataaag tcactgacat tctttagagt 2880
gggttgggtg catccaaaaa tgtataaaaa tattattata ataaacttat tactgcttgt 2940
agggtaattc acagttactt accctattct tgcttggaac atgagcctgg agacccatgg 3000
cagtccatat gcctccctat gcagtgaagg gccctagcag tgttaacaaa ttgctgagat 3060
cccacggagt ctttcaaaaa tctctgtaga gttagtcttc tccttttctc ttcctgagaa 3120
gttctcctgc ctgcataacc attcattagg gagtacttta caagcatgaa ggatattagg 3180
gtaagtggct aattataaat ctactctaga gacatataat catacagatt attcataaaa 3240
tttttcagtg ctgtccttcc acatttaatt gcattttgct caaactgtag aatgccctac 3300
attcccccca ccccaatttg ctatttcctt attaaaaatg tataaaaata ttattataat 3360
aaacttatta ctgcttgtag ggtaattcac agttacttac cctattcttg cttggaacat 3420
gagcctggag acccatggca gtccatatgc ctccctatgc agtgaagggc cctagcagtg 3480
ttaacaaatt gctgagatcc cacggagtct ttcaaaaatc tctgtagagt tagtcttctc 3540
cttttctctt cctgagaagt tctcctgcct gcataaccat tcattaggga gtactttaca 3600
agcatgaagg atattagggt aagtggctaa ttataaatct actctagaga catataatca 3660
tacagattat tcataaaatt tttcagtgct gtccttccac atttaattgc attttgctca 3720
aactgtagaa tgccctacat tccccccacc ccaatttgct atttccttat taaaatagaa 3780
aattataggc aagatacaat tatatgcgtt cctcttcctg aaattataac atttctaaac 3840
ttacccacgt agggactact gaatccaact gccaacaata aaaagacttt tatttagtag 3900
aggctacctt tccccccagt gactcttttt ctacaactgc cttgtcagtt tggtaattca 3960
cttatgattt tctaatgttc tcttggtgaa ttttattatc ttggaccctc tttttttttt 4020
tttttaaaga cagagtcttg ctctgtcacc cattgctctc gtttgggcaa caagagtgaa 4080
actcttgtct caaaaaaaaa aaaaaatgag gtttaagaca gttttgtcat tactggtggg 4140
atctggtcac acaagatagc attaaacgtg acatggcaca taaaattggt taaaaaattt 4200
tgttttttaa ttgcgtaatg taaaagccca acaaacactt tatgcaagat tggaatgtat 4260
cttcaaattc agatttaata aacatgtaaa gatcctctgt aaaaaaaaaa aaaaaaaaaa 4320
aaaaaaaaa                                                         4329
<210> 23
<211> 1680
<212> DNA
<213> Homo sapiens
<400> 23
acgcggggga tccagcttgg gtaggcgggg aagcagctgg agtgcgaccg ctacggcagc 60
caccctgcaa ccgccagtcg gagagctaag ggcaagtcct gaggttgggc ccaggagaaa 120
gaaggcaagg agacattgtc ccaggatatt cttggtgatc ttggaagtgt ccgtatcatg 180
gaatcaatct ctatgatggg aagccctaag agccttagtg aaacttgttt acctaatggc 240
ataaatggta tcaaagatgc aaggaaggtc actgtaggtg tgattggaag tggagatttt 300
gccaaatcct tgaccattcg acttattaga tgcggctatc atgtggtcat aggaagtaga 360
aatcctaagt ttgcttctga attttttcct catgtggtag atgtcactca tcatgaagat 420
gctctcacaa aaacaaatat aatatttgtt gctatacaca gagaacatta tacctccctg 480
tgggacctga gacatctgct tgtgggtaaa atcctgattg atgtgagcaa taacatgagg 540
ataaaccagt acccagaatc caatgctgaa tatttggctt cattattccc agattctttg 600
attgtcaaag gatttaatgt tgtctcagct tgggcacttc agttaggacc taaggatgcc 660
agccggcagg tttatatatg cagcaacaat attcaagcgc gacaacaggt tattgaactt 720
gcccgccagt tgaatttcat tcccattgac ttgggatcct tatcatcagc cagagagatt 780
gaaaatttac ccctacgact ctttactttc tggagagggc cagtggtggt agctataagc 840
ttggccacat tttttttcct ttattccttt gtcagagatg tgattcatcc atatgctaga 900
aaccaacaga gtgactttta caaaattcct atagagattg tgaataaaac cttacctata 960
gttgccatta ctttgctctc cctagtatac cttgcaggtc ttctggcagc tgcttatcaa 1020
ctttattacg gcaccaagta taggagattt ccaccttggt tggaaacctg gttacagtgt 1080
agaaaacagc ttggattact aagttttttc ttcgctatgg tccatgttgc ctacagcctc 1140
tgcttaccga tgagaaggtc agagagatat ttgtttctca acatggctta tcagcaggtt 1200
catgcaaata ttgaaaactc ttggaatgag gaagaagttt ggagaattga aatgtatatc 1260
tcctttggca taatgagcct tggcttactt tccctcctgg cagtcacttc tatcccttca 1320
gtgagcaatg ccttaaactg gagagaattc agttttattc agtctacact tggatatgtc 1380
gctctgctca taagtacttt ccatgtttta atttatggat ggaaacgagc ttttgaggaa 1440
gagtactaca gattttatac accaccaaac tttgttcttg ctcttgtttt gccctcaatt 1500
gtaattctgg gtaagattat tttattcctt ccatgtataa gccgaaagct aaaacgaatt 1560
aaaaaaggct gggaaaagag ccaatttctg gaagaaggta ttggaggaac aattcctcat 1620
gtctccccgg agagggtcac agtaatgtga tgataaatgg tgttcacagc tgccatataa 1680
<210> 24
<211> 75
<212> DNA
<213> Homo sapiens
<400> 24
gatccagctt gggtaggcgg ggaagcagct ggagtgcgac cgccgcggca gccaccctgc 60
aaccgccagt cggag                                                  75
<210> 25
<211> 79
<212> DNA
<213> Homo sapiens
<400> 25
agagctaagg gcaagtcctg aggttgggcc caggagaaag aaggcaagga gacattgtcc 60
caggtaggat gtgtcccag                                              79
<210> 26
<211> 718
<212> DNA
<213> Homo sapiens
<400> 26
atcttttgca gctttgcaga tacccagact gagctggaac tggaatttgt cttcctattg 60
actctacttc tttaaaagcg gctgcccatt acattcctca gctgtccttg cagttaggtg 120
tacatgtgac tgagtgttgg ccagtgagat gaagtctcct caaaggaagg cagcatgtgt 180
cctttttcat cccttcatct tgctgctggg attgtggata taacaggagc cctggcagct 240
gtctccagag gatcaaagcc acacccaaag agtaaggcag attagagacc agaaagacct 300
tgactacttc cctacttcca ctgctttttc ctgcatttaa gccattgtaa atctgggtgt 360
gttacatgaa gtgaaaatta attctttctg cccttcagtt ctttatcctg ataccattta 420
acactgtctg aattaactag actgcaataa ttctttcttt tgaaagcttt taaaggataa 480
tgtgcaattc acattaaaat tgattttcca ttgtcaatta gttatactca ttttcctgcc 540
ttgatctttc attagatatt ttgtatctgc ttggaatata ttatcttctt tttaactgtg 600
taattggtaa ttactaaaac tctgtaatct ccaaaatatt gctatcaaat tacacaccat 660
gttttctatc attctcatag atctgcctta taaacattta aataaaaagt actattta   718
<210> 27
<211> 2238
<212> DNA
<213> Homo sapiens
<400> 27
gatccagctt gggtaggcgg ggaagcagct ggagtgcgac cgccgcggca gccaccctgc 60
aaccgccagt cggagagagc taagggcaag tcctgaggtt gggcccagga gaaagaaggc 120
aaggagacat tgtcccaggt aggatgtgtc ccaggatatt cttggtgatc ttggaagtgt 180
ccgtatcatg gaatcaatct ctatgatggg aagccctaag agccttagtg aaactttttt 240
acctaatggc ataaatggta tcaaagatgc aaggaaggtc actgtaggtg tgattggaag 300
tggagatttt gccaaatcct tgaccattcg acttattaga tgcggctatc atgtggtcat 360
aggaagtaga aatcctaagt ttgcttctga attttttcct catgtggtag atgtcactca 420
tcatgaagat gctctcacaa aaacaaatat aatatttgtt gctatacaca gagaacatta 480
tacctccctg tgggacctga gacatctgct tgtgggtaaa atcctgattg atgtgagcaa 540
taacatgagg ataaaccagt acccagaatc caatgctgaa tatttggctt cattattccc 600
agattctttg attgtcaaag gatttaatgt tgtctcagct tgggcacttc agttaggacc 660
taaggatgcc agccggcagg tttatatatg cagcaacaat attcaagcgc gacaacaggt 720
tattgaactt gcccgccagt tgaatttcat tcccattgac ttgggatcct tatcatcagc 780
cagagagatt gaaaatttac ccctacgact ctttactctc tggagagggc cagtggtggt 840
agctataagc ttggccacat tttttttcct ttattccttt gtcagagatg tgattcatcc 900
atatgctaga aaccaacaga gtgactttta caaaattcct atagagattg tgaataaaac 960
cttacctata gttgccatta ctttgctctc cctagtatac ctcgcaggtc ttctggcagc 1020
tgcttatcaa ctttattacg gcaccaagta taggagattt ccaccttggt tggaaacctg 1080
gttacagtgt agaaaacagc ttggattact aagttttttc ttcgctatgg tccatgttgc 1140
ctacagcctc tgcttaccga tgagaaggtc agagagatat ttgtttctca acatggctta 1200
tcagcaggtt catgcaaata ttgaaaactc ttggaatgag gaagaagttt ggagaattga 1260
aatgtatatc tcctttggca taatgagcct tggcttactt tccctcctgg cagtcacttc 1320
tatcccttca gtgagcaatg ctttaaactg gagagaattc agttttattc agtctacact 1380
tggatatgtc gctctgctca taagtacttt ccatgtttta atttatggat ggaaacgagc 1440
ttttgaggaa gagtactaca gattttatac accaccaaac tttgttcttg ctcttgtttt 1500
gccctcaatt gtaattctgg atcttttgca gctttgcaga tacccagact gagctggaac 1560
tggaatttgt cttcctattg actctacttc tttaaaagcg gctgcccatt acattcctca 1620
gctgtccttg cagttaggtg tacatgtgac tgagtgttgg ccagtgagat gaagtctcct 1680
caaaggaagg cagcatgtgt cctttttcat cccttcatct tgctgctggg attgtggata 1740
taacaggagc cctggcagct gtctccagag gatcaaagcc acacccaaag agtaaggcag 1800
attagagacc agaaagacct tgactacttc cctacttcca ctgctttttc ctgcatttaa 1860
gccattgtaa atctgggtgt gttacatgaa gtgaaaatta attctttctg cccttcagtt 1920
ctttatcctg ataccattta acactgtctg aattaactag actgcaataa ttctttcttt 1980
tgaaagcttt taaaggataa tgtgcaattc acattaaaat tgattttcca ttgtcaatta 2040
gttatactca ttttcctgcc ttgatctttc attagatatt ttgtatctgc ttggaatata 2100
ttatcttctt tttaactgtg taattggtaa ttactaaaac tctgtaatct ccaaaatatt 2160
gctatcaaat tacacaccat gttttctatc attctcatag atctgcctta taaacattta 2220
aataaaaagt actattta                                               2238
<210> 28
<211> 1561
<212> DNA
<213> Homo sapiens
<400> 28
gatccagctt gggtaggcgg ggaagcagct ggagtgcgac cgccgcggca gccaccctgc 60
aaccgccagt cggagagagc taagggcaag tcctgaggtt gggcccagga gaaagaaggc 120
aaggagacat tgtcccaggt aggatgtgtc ccaggatatt cttggtgatc ttggaagtgt 180
ccgtatcatg gaatcaatct ctatgatggg aagccctaag agccttagtg aaacttgttt 240
acctaatggc ataaatggta tcaaagatgc aaggaaggtc actgtaggtg tgattggaag 300
tggagatttt gccaaatcct tgaccattcg acttattaga tgcggctatc atgtggtcat 360
aggaagtaga aatcctaagt ttgcttctga attttttcct catgtggtag atgtcactca 420
tcatgaagat gctctcacaa aaacaaatat aatatttgtt gctatacaca gagaacatta 480
tacctccctg tgggacctga gacatctgct tgtgggtaaa atcctgattg atgtgagcaa 540
taacatgagg ataaaccagt acccagaatc caatgctgaa tatttggctt cattattccc 600
agattctttg attgtcaaag gatttaatgt tgtctcagct tgggcacttc agttaggacc 660
taaggatgcc agccggcagg tttatatatg cagcaacaat attcaagcgc gacaacaggt 720
tattgaactt gcccgccagt tgaatttcat tcccattgac ttgggatcct tatcatcagc 780
cagagagatt gaaaatttac ccctacgact ctttactctc tggagagggc cagtggtggt 840
agctataagc ttggccacat tttttttcct ttattccttt gtcagagatg tgattcatcc 900
atatgctaga aaccaacaga gtgactttta caaaattcct atagagattg tgaataaaac 960
cttacctata gttgccatta ctttgctctc cctagtatac ctcgcaggtc ttctggcagc 1020
tgcttatcaa ctttattacg gcaccaagta taggagattt ccaccttggt tggaaacctg 1080
gttacagtgt agaaaacagc ttggattact aagttttttc ttcgctatgg tccatgttgc 1140
ctacagcctc tgcttaccga tgagaaggtc agagagatat ttgtttctca acatggctta 1200
tcagcaggtt catgcaaata ttgaaaactc ttggaatgag gaagaagttt ggagaattga 1260
aatgtatatc tcctttggca taatgagcct tggcttactt tccctcctgg cagtcacttc 1320
tatcccttca gtgagcaatg ctttaaactg gagagaattc agttttattc agtctacact 1380
tggatatgtc gctctgctca taagtacttt ccatgtttta atttatggat ggaaacgagc 1440
ttttgaggaa gagtactaca gattttatac accaccaaac tttgttcttg ctcttgtttt 1500
gccctcaatt gtaattctgg atcttttgca gctttgcaga tacccagact gagctggaac 1560
t                                                                 1561
<210> 29
<211> 454
<212> PRT
<213> Homo sapiens
<400> 29
Met Glu Ser Ile Ser Met Met Gly Ser Pro Lys Ser Leu Ser Glu Thr
1               5                  10                  15      
Cys Leu Pro Asn Gly Ile Asn Gly Ile Lys Asp Ala Arg Lys Val Thr
20                  25                  30          
Val Gly Val Ile Gly Ser Gly Asp Phe Ala Lys Ser Leu Thr Ile Arg
35                  40                  45              
Leu Ile Arg Cys Gly Tyr His Val Val Ile Gly Ser Arg Asn Pro Lys
50                  55                  60                  
Phe Ala Ser Glu Phe Phe Pro His Val Val Asp Val Thr His His Glu
65                  70                  75                  80  
Asp Ala Leu Thr Lys Thr Asn Ile Ile Phe Val Ala Ile His Arg Glu
85                  90                  95      
His Tyr Thr Ser Leu Trp Asp Leu Arg His Leu Leu Val Gly Lys Ile
100                 105                 110         
Leu Ile Asp Val Ser Asn Asn Met Arg Ile Asn Gln Tyr Pro Glu Ser
115                 120                 125             
Asn Ala Glu Tyr Leu Ala Ser Leu Phe Pro Asp Ser Leu Ile Val Lys
130                 135                 140                 
Gly Phe Asn Val Val Ser Ala Trp Ala Leu Gln Leu Gly Pro Lys Asp
145                 150                 155                 160 
Ala Ser Arg Gln Val Tyr Ile Cys Ser Asn Asn Ile Gln Ala Arg Gln
165                 170                 175     
Gln Val Ile Glu Leu Ala Arg Gln Leu Asn Phe Ile Pro Ile Asp Leu
180                 185                 190         
Gly Ser Leu Ser Ser Ala Arg Glu Ile Glu Asn Leu Pro Leu Arg Leu
195                 200                 205             
Phe Thr Leu Trp Arg Gly Pro Val Val Val Ala Ile Ser Leu Ala Thr
210                 215                 220                 
Phe Phe Phe Leu Tyr Ser Phe Val Arg Asp Val Ile His Pro Tyr Ala
225                 230                 235                 240 
Arg Asn Gln Gln Ser Asp Phe Tyr Lys Ile Pro Ile Glu Ile Val Asn
245                 250                 255     
Lys Thr Leu Pro Ile Val Ala Ile Thr Leu Leu Ser Leu Val Tyr Leu
260                 265                 270         
Ala Gly Leu Leu Ala Ala Ala Tyr Gln Leu Tyr Tyr Gly Thr Lys Tyr
275                 280                 285             
Arg Arg Phe Pro Pro Trp Leu Glu Thr Trp Leu Gln Cys Arg Lys Gln
290                 295                 300                 
Leu Gly Leu Leu Ser Phe Phe Phe Ala Met Val His Val Ala Tyr Ser
305                 310                 315                 320 
Leu Cys Leu Pro Met Arg Arg Ser Glu Arg Tyr Leu Phe Leu Asn Met
325                 330                 335     
Ala Tyr Gln Gln Val His Ala Asn Ile Glu Asn Ser Trp Asn Glu Glu
340                 345                 350         
Glu Val Trp Arg Ile Glu Met Tyr Ile Ser Phe Gly Ile Met Ser Leu
355                 360                 365             
Gly Leu Leu Ser Leu Leu Ala Val Thr Ser Ile Pro Ser Val Ser Asn
370                 375                 380                 
Ala Leu Asn Trp Arg Glu Phe Ser Phe Ile Gln Ser Thr Leu Gly Tyr
385                 390                 395                 400 
Val Ala Leu Leu Ile Ser Thr Phe His Val Leu Ile Tyr Gly Trp Lys
405                 410                 415     
Arg Ala Phe Glu Glu Glu Tyr Tyr Arg Phe Tyr Thr Pro Pro Asn Phe
420                 425                 430         
Val Leu Ala Leu Val Leu Pro Ser Ile Val Ile Leu Asp Leu Leu Gln
435                 440                 445             
Leu Cys Arg Tyr Pro Asp
450                 
<210> 30
<211> 2102
<212> DNA
<213> Homo sapiens
<400> 30
ggatccagct tgggtaggcg gggaagcagc tggagtgcga ccgctacggc agccaccctg 60
caaccgccag tcggagagct aagggcaagt cctgaggttg ggcccaggag aaagaaggca 120
aggagacatt gtcccaggat attcttggtg atcttggaag tgtccgtatc atggaatcaa 180
tctctatgat gggaagccct aagagcctta gtgaaacttg tttacctaat ggcataaatg 240
gtatcaaaga tgcaaggaag gtcactgtag gtgtgattgg aagtggagat tttgccaaat 300
ccttgaccat tcgacttatt agatgcggct atcatgtggt cataggaagt agaaatccta 360
agtttgcttc tgaatttttt cctcatgtgg tagatgtcac tcatcatgaa gatgctctca 420
caaaaacaaa tataatattt gttgctatac acagagaaca ttatacctcc ctgtgggacc 480
tgagacatct gcttgtgggt aaaatcctga ttgatgtgag caataacatg aggataaacc 540
agtacccaga atccaatgct gaatatttgg cttcattatt cccagattct ttgattgtca 600
aaggatttaa tgttgtctca gcttgggcac ttcagttagg acctaaggat gccagccggc 660
aggtttatat atgcagcaac aatattcaag cgcgacaaca ggttattgaa cttgcccgcc 720
agttgaattt cattcccatt gacttgggat ccttatcatc agccagagag attgaaaatt 780
tacccctacg actctttact ttctggagag ggccagtggt ggtagctata agcttggcca 840
catttttttt cctttattcc tttgtcagag atgtgattca tccatatgct agaaaccaac 900
agagtgactt ttacaaaatt cctatagaga ttgtgaataa aaccttacct atagttgcca 960
ttactttgct ctccctagta taccttgcag gtcttctggc agctgcttat caactttatt 1020
acggcaccaa gtataggaga tttccacctt ggttggaaac ctggttacag tgtagaaaac 1080
agcttggatt actaagtttt ttcttcgcta tggtccatgt tgcctacagc ctctgcttac 1140
cgatgagaag gtcagagaga tatttgtttc tcaacatggc ttatcagcag gttcatgcaa 1200
atattgaaaa ctcttggaat gaggaagaag tttggagaat tgaaatgtat atctcctttg 1260
gcataatgag ccttggctta ctttccctcc tggcagtcac ttctatccct tcggtgagca 1320
atgctttaaa ctggagagaa ttcagtttta ttcagatctt ttgcagcttt gcagataccc 1380
agactgagct ggaactggaa tttgtcttcc tattgactct acttctttaa aagcggctgc 1440
ccattacatt cctcagctgt ccttgcagtt aggtgtacat gtgactgagt gttggccagt 1500
gagatgaagt ctcctcaaag gaaggcagca tgtgtccttt ttcatccctt catcttgctg 1560
ctgggattgt ggatataaca ggagccctgg cagctgctcc agaggatcaa agccacaccc 1620
aaagagtaag gcagattaga gaccagaaag accttgacta cttccctact tccactgctt 1680
tttcctgcat ttaagccatt gtaaatctgg gtgtgttaca tgaagtgaaa attaattctt 1740
tctgcccttc agttctttat cctgatacca tttaacactg tctgaattaa ctagactgca 1800
ataattcttt cttttgaaag cttttaaagg ataatgtgca attcacatta aaattgattt 1860
tccattgtca attagttata ctcattttcc tgccttgatc tttcattaga tattttgtat 1920
ctgcttggaa tatattatct tctttttaac tgtgtaattg gtaattacta aaactctgta 1980
atctccaaaa tattgctatc aaattacaca ccatgttttc tatcattctc atagatctgc 2040
cttataaaca tttaaataaa aagtactatt taccaaaaaa aaaaaaaaaa aaaaaaaaaa 2100
aa                                                                2102
<210> 31
<211> 2102
<212> DNA
<213> Homo sapiens
<400> 31
ggatccagct tgggtaggcg gggaagcagc tggagtgcga ccgctacggc agccaccctg 60
caaccgccag tcggagagct aagggcaagt cctgaggttg ggcccaggag aaagaaggca 120
aggagacatt gtcccaggat attcttggtg atcttggaag tgtccgtatc atggaatcaa 180
tctctatgat gggaagccct aagagcctta gtgaaacttg tttacctaat ggcataaatg 240
gtatcaaaga tgcaaggaag gtcactgtag gtgtgattgg aagtggagat tttgccaaat 300
ccttgaccat tcgacttatt agatgcggct atcatgtggt cataggaagt agaaatccta 360
agtttgcttc tgaatttttt cctcatgtgg tagatgtcac tcatcatgaa gatgctctca 420
caaaaacaaa tataatattt gttgctatac acagagaaca ttatacctcc ctgtgggacc 480
tgagacatct gcttgtgggt aaaatcctga ttgatgtgag caataacatg aggataaacc 540
agtacccaga atccaatgct gaatatttgg cttcattatt cccagattct ttgattgtca 600
aaggatttaa tgttgtctca gcttgggcac ttcagttagg acctaaggat gccagccggc 660
aggtttatat atgcagcaac aatattcaag cgcgacaaca ggttattgaa cttgcccgcc 720
agttgaattt cattcccatt gacttgggat ccttatcatc agccagagag attgaaaatt 780
tacccctacg actctttact ttctggagag ggccagtggt ggtagctata agcttggcca 840
catttttttt cctttattcc tttgtcagag atgtgattca tccatatgct agaaaccaac 900
agagtgactt ttacaaaatt cctatagaga ttgtgaataa aaccttacct atagttgcca 960
ttactttgct ctccctagta taccttgcag gtcttctggc agctgcttat caactttatt 1020
acggcaccaa gtataggaga tttccacctt ggttggaaac ctggttacag tgtagaaaac 1080
agcttggatt actaagtttt ttcttcgcta tggtccatgt tgcctacagc ctctgcttac 1140
cgatgagaag gtcagagaga tatttgtttc tcaacatggc ttatcagcag gttcatgcaa 1200
atattgaaaa ctcttggaat gaggaagaag tttggagaat tgaaatgtat atctcctttg 1260
gcataatgag ccttggctta ctttccctcc tggcagtcac ttctatccct tcggtgagca 1320
atgctttaaa ctggagagaa ttcagtttta ttcagatctt ttgcagcttt gcagataccc 1380
agactgagct ggaactggaa tttgtcttcc tattgactct acttctttaa aagcggctgc 1440
ccattacatt cctcagctgt ccttgcagtt aggtgtacat gtgactgagt gttggccagt 1500
gagatgaagt ctcctcaaag gaaggcagca tgtgtccttt ttcatccctt catcttgctg 1560
ctgggattgt ggatataaca ggagccctgg cagctgctcc agaggatcaa agccacaccc 1620
aaagagtaag gcagattaga gaccagaaag accttgacta cttccctact tccactgctt 1680
tttcctgcat ttaagccatt gtaaatctgg gtgtgttaca tgaagtgaaa attaattctt 1740
tctgcccttc agttctttat cctgatacca tttaacactg tctgaattaa ctagactgca 1800
ataattcttt cttttgaaag cttttaaagg ataatgtgca attcacatta aaattgattt 1860
tccattgtca attagttata ctcattttcc tgccttgatc tttcattaga tattttgtat 1920
ctgcttggaa tatattatct tctttttaac tgtgtaattg gtaattacta aaactctgta 1980
atctccaaaa tattgctatc aaattacaca ccatgttttc tatcattctc atagatctgc 2040
cttataaaca tttaaataaa aagtactatt taccaaaaaa aaaaaaaaaa aaaaaaaaaa 2100
aa                                                                2102
<210> 32
<211> 419
<212> PRT
<213> Homo sapiens
<400> 32
Met Glu Ser Ile Ser Met Met Gly Ser Pro Lys Ser Leu Ser Glu Thr
1               5                  10                  15      
Cys Leu Pro Asn Gly Ile Asn Gly Ile Lys Asp Ala Arg Lys Val Thr
20                  25                  30          
Val Gly Val Ile Gly Ser Gly Asp Phe Ala Lys Ser Leu Thr Ile Arg
35                  40                  45              
Leu Ile Arg Cys Gly Tyr His Val Val Ile Gly Ser Arg Asn Pro Lys
50                  55                  60                  
Phe Ala Ser Glu Phe Phe Pro His Val Val Asp Val Thr His His Glu
65                  70                  75                  80  
Asp Ala Leu Thr Lys Thr Asn Ile Ile Phe Val Ala Ile His Arg Glu
85                  90                  95      
His Tyr Thr Ser Leu Trp Asp Leu Arg His Leu Leu Val Gly Lys Ile
100                 105                 110         
Leu Ile Asp Val Ser Asn Asn Met Arg Ile Asn Gln Tyr Pro Glu Ser
115                 120                 125             
Asn Ala Glu Tyr Leu Ala Ser Leu Phe Pro Asp Ser Leu Ile Val Lys
130                 135                 140                 
Gly Phe Asn Val Val Ser Ala Trp Ala Leu Gln Leu Gly Pro Lys Asp
145                 150                 155                 160 
Ala Ser Arg Gln Val Tyr Ile Cys Ser Asn Asn Ile Gln Ala Arg Gln
165                 170                 175     
Gln Val Ile Glu Leu Ala Arg Gln Leu Asn Phe Ile Pro Ile Asp Leu
180                 185                 190         
Gly Ser Leu Ser Ser Ala Arg Glu Ile Glu Asn Leu Pro Leu Arg Leu
195                 200                 205             
Phe Thr Phe Trp Arg Gly Pro Val Val Val Ala Ile Ser Leu Ala Thr
210                 215                 220                 
Phe Phe Phe Leu Tyr Ser Phe Val Arg Asp Val Ile His Pro Tyr Ala
225                 230                 235                 240 
Arg Asn Gln Gln Ser Asp Phe Tyr Lys Ile Pro Ile Glu Ile Val Asn
245                 250                 255     
Lys Thr Leu Pro Ile Val Ala Ile Thr Leu Leu Ser Leu Val Tyr Leu
260                 265                 270         
Ala Gly Leu Leu Ala Ala Ala Tyr Gln Leu Tyr Tyr Gly Thr Lys Tyr
275                 280                 285             
Arg Arg Phe Pro Pro Trp Leu Glu Thr Trp Leu Gln Cys Arg Lys Gln
290                 295                 300                 
Leu Gly Leu Leu Ser Phe Phe Phe Ala Met Val His Val Ala Tyr Ser
305                 310                 315                 320 
Leu Cys Leu Pro Met Arg Arg Ser Glu Arg Tyr Leu Phe Leu Asn Met
325                 330                 335     
Ala Tyr Gln Gln Val His Ala Asn Ile Glu Asn Ser Trp Asn Glu Glu
340                 345                 350         
Glu Val Trp Arg Ile Glu Met Tyr Ile Ser Phe Gly Ile Met Ser Leu
355                 360                 365             
Gly Leu Leu Ser Leu Leu Ala Val Thr Ser Ile Pro Ser Val Ser Asn
370                 375                 380                 
Ala Leu Asn Trp Arg Glu Phe Ser Phe Ile Gln Ile Phe Cys Ser Phe
385                 390                 395                 400 
Ala Asp Thr Gln Thr Glu Leu Glu Leu Glu Phe Val Phe Leu Leu Thr
405                 410                 415     
Leu Leu Leu
<210> 33
<211> 1396
<212> DNA
<213> Homo sapiens
<400> 33
acagatctat ggagaaaact tgtatagatg cacttcctct tactatgaat tcttcagaaa 60
agcaagagac tgtatgtatt tttggaactg gtgattttgg aagatcactg ggattgaaaa 120
tgctccagtg tggttattct gttgtttttg gaagtcgaaa cccccagaag accaccctac 180
tgcccagtgg tgcagaagtc ttgagctatt cagaagcagc caagaagtct gacatcataa 240
tcatagcaat ccacagagag cattatgatt ttctcacaga attaactgag gttctcaatg 300
gaaaaatatt ggtagacatc agcaacaacc tcaaaatcaa tcaatatcca gaatctaatg 360
cagagtacct tgctcatttg gtgccaggag cccacgtggt aaaagcattt aacaccatct 420
cagcctgggc tctccagtca ggagcactgg atgcaagtcg gcaggtgttt gtgtgtggaa 480
atgacagcaa agccaagcaa agagtgatgg atattgttcg taatcttgga cttactccaa 540
tggatcaagg atcactcatg gcagccaaag aaattgaaaa gtaccccctg cagctatttc 600
caatgtggag gttccccttc tatttgtctg ctgtgctgtg tgtcttcttg tttttctatt 660
gtgttataag agacgtaatc tacccttatg tttatgaaaa gaaagataat acatttcgta 720
tggctatttc cattccaaat cgtatctttc caataacagc acttacactg cttgctttgg 780
tttacctccc tggtgttatt gctgccattc tacaactgta ccgaggcaca aaataccgtc 840
gattcccaga ctggcttgac cactggatgc tttgccgaaa gcagcttggc ttggtagctc 900
tgggatttgc cttccttcat gtcctctaca cacttgtgat tcctattcga tattatgtac 960
gatggagatt gggaaactta accgttaccc aggcaatacc caagaaggag aatccattta 1020
gcacctcctc agcctggctc agtgattcat atgtggcttt gggaatactt gggttttttc 1080
tgtttgtact cttgggaatc acttctttgc catctgttag caatgcagtc aactggagag 1140
agttccgatt tgtccagtcc aaactgggtt atttgaccct gatcttgtgt acagcccaca 1200
ccctggtgta cggtgggaag agattcctca gcccttcaaa tctcagatgg tatcttcctg 1260
cagcctacgt gttagggctt atcattcctt gcactgtgct ggtgatcaag tttgtcctaa 1320
tcatgccatg tgtagacaac acccttacaa ggatccgcca gggctgggaa aggaactcaa 1380
aacactagct cgaggt                                                 1396
<210> 34
<211> 459
<212> PRT
<213> Homo sapiens
<220> 
<221> VARIANT        
<222> 122
<223> Xaa = Ala or Thr
<221> VARIANT        
<222> 331
<223> Xaa = Pro or Leu
<400> 34
Met Glu Lys Thr Cys Ile Asp Ala Leu Pro Leu Thr Met Asn Ser Ser
1               5                  10                  15      
Glu Lys Gln Glu Thr Val Cys Ile Phe Gly Thr Gly Asp Phe Gly Arg
20                  25                  30          
Ser Leu Gly Leu Lys Met Leu Gln Cys Gly Tyr Ser Val Val Phe Gly
35                  40                  45              
Ser Arg Asn Pro Gln Lys Thr Thr Leu Leu Pro Ser Gly Ala Glu Val
50                  55                  60                  
Leu Ser Tyr Ser Glu Ala Ala Lys Lys Ser Asp Ile Ile Ile Ile Ala
65                  70                  75                  80  
Ile His Arg Glu His Tyr Asp Phe Leu Thr Glu Leu Thr Glu Val Leu
85                  90                  95      
Asn Gly Lys Ile Leu Val Asp Ile Ser Asn Asn Leu Lys Ile Asn Gln
100                 105                 110         
Tyr Pro Glu Ser Asn Ala Glu Tyr Leu Xaa His Leu Val Pro Gly Ala
115                 120                 125             
His Val Val Lys Ala Phe Asn Thr Ile Ser Ala Trp Ala Leu Gln Ser
130                 135                 140                 
Gly Ala Leu Asp Ala Ser Arg Gln Val Phe Val Cys Gly Asn Asp Ser
145                 150                 155                 160 
Lys Ala Lys Gln Arg Val Met Asp Ile Val Arg Asn Leu Gly Leu Thr
165                 170                 175     
Pro Met Asp Gln Gly Ser Leu Met Ala Ala Lys Glu Ile Glu Lys Tyr
180                 185                 190         
Pro Leu Gln Leu Phe Pro Met Trp Arg Phe Pro Phe Tyr Leu Ser Ala
195                 200                 205             
Val Leu Cys Val Phe Leu Phe Phe Tyr Cys Val Ile Arg Asp Val Ile
210                 215                 220                 
Tyr Pro Tyr Val Tyr Glu Lys Lys Asp Asn Thr Phe Arg Met Ala Ile
225                 230                 235                 240 
Ser Ile Pro Asn Arg Ile Phe Pro Ile Thr Ala Leu Thr Leu Leu Ala
245                 250                 255     
Leu Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Leu Gln Leu Tyr Arg
260                 265                 270         
Gly Thr Lys Tyr Arg Arg Phe Pro Asp Trp Leu Asp His Trp Met Leu
275                 280                 285             
Cys Arg Lys Gln Leu Gly Leu Val Ala Leu Gly Phe Ala Phe Leu His
290                 295                 300                 
Val Leu Tyr Thr Leu Val Ile Pro Ile Arg Tyr Tyr Val Arg Trp Arg
305                 310                 315                 320 
Leu Gly Asn Leu Thr Val Thr Gln Ala Ile Xaa Lys Lys Glu Asn Pro
325                 330                 335     
Phe Ser Thr Ser Ser Ala Trp Leu Ser Asp Ser Tyr Val Ala Leu Gly
340                 345                 350         
Ile Leu Gly Phe Phe Leu Phe Val Leu Leu Gly Ile Thr Ser Leu Pro
355                 360                 365             
Ser Val Ser Asn Ala Val Asn Trp Arg Glu Phe Arg Phe Val Gln Ser
370                 375                 380                 
Lys Leu Gly Tyr Leu Thr Leu Ile Leu Cys Thr Ala His Thr Leu Val
385                 390                 395                 400 
Tyr Gly Gly Lys Arg Phe Leu Ser Pro Ser Asn Leu Arg Trp Tyr Leu
405                 410                 415     
Pro Ala Ala Tyr Val Leu Gly Leu Ile Ile Pro Cys Thr Val Leu Val
420                 425                 430         
Ile Lys Phe Val Leu Ile Met Pro Cys Val Asp Asn Thr Leu Thr Arg
435                 440                 445             
Ile Arg Gln Gly Trp Glu Arg Asn Ser Lys His
450                 455                 
<210> 35
<211> 3910
<212> DNA
<213> Homo sapiens
<400> 35
acccttcgcc gcggaccttc agctgccgcg gtcgctccga gcggcgggcc gcagaggttc 60
aagcgattct cctgcttcag cctccggagt agctgggatt acaggcacgt gccaacacac 120
ccagccacca aaatgccaga agagatggac aagccactga tcagcctcca cctggtggac 180
agcgatagta gccttgccaa ggtccccgat gaggccccca aagtgggcat cctgggtagc 240
ggggactttg cccgctccct ggccacacgc ctggtgggct ctggcttcaa agtggtggtg 300
gggagccgca accccaaacg cacagccagg ctgtatccct cagcggccca agtgactttc 360
caagaggagg cagtgagctc cccggaggtc atctttgtgg ctgtgttccg ggagcactac 420
tcttcactgt gcagtctcag tgaccagctg gcgggcaaga tcctggtgga tgtgagcaac 480
cctacagagc aagagcacct tcagcatcgt gagtccaatg ctgagtacct ggcctccctc 540
ttccccactt gcacagtggt caaggccttc aatgtcatct ctgcctggac cctgcaggct 600
ggcccaaggg atggtaacag gcaggtgccc atctgcggtg accagccaga agccaagcgt 660
gctgtctcgg agatggcgct cgccatgggc ttcatgcccg tggacatggg atccctggcg 720
tcagcctggg aggtggaggc catgcccctg cgcctcctcc cggcctggaa ggtgcccacc 780
ctgctggccc tggggctctt cgtctgcttc tatgcctaca acttcgtccg ggacgttctg 840
cagccctatg tgcaggaaag ccagaacaag ttcttcaagc tgcccgtgtc cgtggtcaac 900
accacactgc cgtgcgtggc ctacgtgctg ctgtcactcg tgtacttgcc cggcgtgctg 960
gcggctgccc tgcagctgcg gcgcggcacc aagtaccagc gcttccccga ctggctggac 1020
cactggctac agcaccgcaa gcagatcggg ctgctcagct tcttctgcgc cgccctgcac 1080
gccctctaca gcttctgctt gccgctgcgc cgcgcccacc gctacgacct ggtcaacctg 1140
gcagtcaagc aggtcttggc caacaagagc cacctctggg tggaggagga ggtctggcgg 1200
atggagatct acctctccct gggagtgctg gccctcggca cgttgtccct gctggccgtg 1260
acctcactgc cgtccattgc aaactcgctc aactggaggg agttcagctt cgttcagtcc 1320
tcactgggct ttgtggccct cgtgctgagc acactgcaca cgctcaccta cggctggacc 1380
cgcgccttcg aggagagccg ctacaagttc tacctgcctc ccaccttcac gctcacgctg 1440
ctggtgccct gcgtcgtcat cctggccaaa gccctgtttc tcctgccctg catcagccgc 1500
agactcgcca ggatccggag aggctgggag agggagagca ccatcaagtt cacgctgccc 1560
acagaccacg ccctggccga gaagacgagc cacgtatgag gtgcctgccc tgggctctgg 1620
accccgggca cacgagggac ggtgccctga gcccgttagg ttttcttttc ttggtggtgc 1680
aaagtggtat aactgtgtgc aaataggagg tttgaggtcc aaattcctgg gactcaaatg 1740
tatgcagtac tattcagaat gatatacaca catatgtgta tatgtattta catatattcc 1800
acatatataa caggatttgc aattatacat agctagctaa aaagttgggt ctctgagatt 1860
tcaacttgta gatttaaaaa caagtgccgt acgttaagag aagagcagat catgctattg 1920
tgacatttgc agagatatac acacactttt tgtacagaag aggcttgtgc tgtggtgggt 1980
tcgatttatc cctgcccacc ccatccccac aacttccctt ttgctacttc cccaaggctc 2040
ttgcagagct agggctctga aggggaggga aggcaacggc tctgcccaga gccatccctg 2100
gagcatgtga gcagcggctg gtctcttccc tccacctggg gcagcagcag gaggcctggg 2160
ggggaggaaa atcaggcagt cggcctggag tctgtgcctg gtcctttgcc cggtggtggg 2220
aggatggagg gattgggctg aagctgctcc acctcatcct tgctgagtgg gggagacatt 2280
ttccctgaaa gtcagaagtc accatagagc ctgcaaatgg atcctcctgt gagagtgacg 2340
tcacctcctt tccagagcca ttagtgagcc tggcttggga acaagtgtaa tttccttccc 2400
tcctttaacc tggcgatgag cgtcctttaa accactgtgc cttctcaccc tttccatctt 2460
cagtttgaac gactcccagg aaggcctaga gcagaccctt tagaaatcag cccaaggggg 2520
agagcaagag aaaacactct agggagtaaa gctccccggg cgtcagagtt gagccctgcc 2580
tgggctgaag gactgtcttc acgaagtcag tcctgaggaa aaatattggg gactccaaat 2640
gtcctctggc agaggaccca gaaaaccaca ctggctccaa cttcctcctc atggggcatt 2700
acacttcaaa acagtgggga gcaacttttc caccaaagct acaaacctaa aatgctgctg 2760
ccccaaagca caagagggaa gagcaccgcc ggggccacag gacgtctgtc ctccagtcac 2820
aggccatcct tgctgctccc tactgactct agcttacttc ccctgtgaag aaacaggtgt 2880
tctcggctga gcccccaacc ctctgcagaa ccaggttgat ctgccacaga aaaagcatct 2940
ttgaagacaa agagggtgag gtcttcatga gtctcctggg cccaaagcca tcttctgatg 3000
gaaggaagag agtagggcca gtgaaggctg cccagagaga atgtcacaga tgaggctgcc 3060
cctgccccct ccccgccagg gaggtttcat gagctcatgt ctatgcagca cataagggtt 3120
cttcagtgaa aagcaggaga agagcccact gcaaggatag ctcattaggc acatgaccga 3180
tgcagggaag gccatgccgg ggaagctctt cctgcaggta ttttccatct gctgtgccaa 3240
ggctgagcgg cagaaacttg tctcataaat tggcactgat ggagcatcag ctgtggccca 3300
cagagagcct tgctgagaag ggggcaggta aagcagagat tttagcattg ccttggcata 3360
acaagggccc atcgattccc tactaatgag aggcagggag agcatgggca atggagaccc 3420
accaatgatc cccaaccccg gtgggtactg gctgcctgcc ctgggccagg gaatggctcc 3480
ttataccaaa gatgctggca catagcagaa cccagtgcac gtcctcccct tcccacccac 3540
ctctggctga aggtgctcaa gagggaagca attataaggt gggtggcagg agggaacagg 3600
tgccacctgc tggacaatca cacgaaaggc aggcgggctg tgtactgggc cctgactgtg 3660
cgtccactgc tgtcttccct acctcaccag gctactggca gcagcatccc gagagcacat 3720
catctccaca gcctggtaaa ttccatgtgc ctctgggtac aaaagtgcct caacgacatg 3780
ctctggaaat cccaaatgcc acagtctgag gttgatatct aaaatctatg ccttcaaaag 3840
agtctctgtt tttttttttt aacctggtag acggtataaa agcagtgcaa ataaacacct 3900
aaccttctgc                                                        3910
<210> 36
<211> 488
<212> PRT
<213> Homo sapiens
<400> 36
Met Pro Glu Glu Met Asp Lys Pro Leu Ile Ser Leu His Leu Val Asp
1               5                  10                  15      
Ser Asp Ser Ser Leu Ala Lys Val Pro Asp Glu Ala Pro Lys Val Gly
20                  25                  30          
Ile Leu Gly Ser Gly Asp Phe Ala Arg Ser Leu Ala Thr Arg Leu Val
35                  40                  45              
Gly Ser Gly Phe Lys Val Val Val Gly Ser Arg Asn Pro Lys Arg Thr
50                  55                  60                  
Ala Arg Leu Tyr Pro Ser Ala Ala Gln Val Thr Phe Gln Glu Glu Ala
65                  70                  75                  80  
Val Ser Ser Pro Glu Val Ile Phe Val Ala Val Phe Arg Glu His Tyr
85                  90                  95      
Ser Ser Leu Cys Ser Leu Ser Asp Gln Leu Ala Gly Lys Ile Leu Val
100                 105                 110         
Asp Val Ser Asn Pro Thr Glu Gln Glu His Leu Gln His Arg Glu Ser
115                 120                 125             
Asn Ala Glu Tyr Leu Ala Ser Leu Phe Pro Thr Cys Thr Val Val Lys
130                 135                 140                 
Ala Phe Asn Val Ile Ser Ala Trp Thr Leu Gln Ala Gly Pro Arg Asp
145                 150                 155                 160 
Gly Asn Arg Gln Val Pro Ile Cys Gly Asp Gln Pro Glu Ala Lys Arg
165                 170                 175     
Ala Val Ser Glu Met Ala Leu Ala Met Gly Phe Met Pro Val Asp Met
180                 185                 190         
Gly Ser Leu Ala Ser Ala Trp Glu Val Glu Ala Met Pro Leu Arg Leu
195                 200                 205             
Leu Pro Ala Trp Lys Val Pro Thr Leu Leu Ala Leu Gly Leu Phe Val
210                 215                 220                 
Cys Phe Tyr Ala Tyr Asn Phe Val Arg Asp Val Leu Gln Pro Tyr Val
225                 230                 235                 240 
Gln Glu Ser Gln Asn Lys Phe Phe Lys Leu Pro Val Ser Val Val Asn
245                 250                 255     
Thr Thr Leu Pro Cys Val Ala Tyr Val Leu Leu Ser Leu Val Tyr Leu
260                 265                 270         
Pro Gly Val Leu Ala Ala Ala Leu Gln Leu Arg Arg Gly Thr Lys Tyr
275                 280                 285             
Gln Arg Phe Pro Asp Trp Leu Asp His Trp Leu Gln His Arg Lys Gln
290                 295                 300                 
Ile Gly Leu Leu Ser Phe Phe Cys Ala Ala Leu His Ala Leu Tyr Ser
305                 310                 315                 320 
Phe Cys Leu Pro Leu Arg Arg Ala His Arg Tyr Asp Leu Val Asn Leu
325                 330                 335     
Ala Val Lys Gln Val Leu Ala Asn Lys Ser His Leu Trp Val Glu Glu
340                 345                 350         
Glu Val Trp Arg Met Glu Ile Tyr Leu Ser Leu Gly Val Leu Ala Leu
355                 360                 365             
Gly Thr Leu Ser Leu Leu Ala Val Thr Ser Leu Pro Ser Ile Ala Asn
370                 375                 380                 
Ser Leu Asn Trp Arg Glu Phe Ser Phe Val Gln Ser Ser Leu Gly Phe
385                 390                 395                 400 
Val Ala Leu Val Leu Ser Thr Leu His Thr Leu Thr Tyr Gly Trp Thr
405                 410                 415     
Arg Ala Phe Glu Glu Ser Arg Tyr Lys Phe Tyr Leu Pro Pro Thr Phe
420                 425                 430         
Thr Leu Thr Leu Leu Val Pro Cys Val Val Ile Leu Ala Lys Ala Leu
435                 440                 445             
Phe Leu Leu Pro Cys Ile Ser Arg Arg Leu Ala Arg Ile Arg Arg Gly
450                 455                 460                 
Trp Glu Arg Glu Ser Thr Ile Lys Phe Thr Leu Pro Thr Asp His Ala
465                 470                 475                 480 
Leu Ala Glu Lys Thr Ser His Val
485             
<210> 37
<211> 339
<212> PRT
<213> Homo sapiens
<400> 37
Met Glu Ser Arg Lys Asp Ile Thr Asn Gln Glu Glu Leu Trp Lys Met
1               5                  10                  15      
Lys Pro Arg Arg Asn Leu Glu Glu Asp Asp Tyr Leu His Lys Asp Thr
20                  25                  30          
Gly Glu Thr Ser Met Leu Lys Arg Pro Val Leu Leu His Leu His Gln
35                  40                  45              
Thr Ala His Ala Asp Glu Phe Asp Cys Pro Ser Glu Leu Gln His Thr
50                  55                  60                  
Gln Glu Leu Phe Pro Gln Trp His Leu Pro Ile Lys Ile Ala Ala Ile
65                  70                  75                  80  
Ile Ala Ser Leu Thr Phe Leu Tyr Thr Leu Leu Arg Glu Val Ile His
85                  90                  95      
Pro Leu Ala Thr Ser His Gln Gln Tyr Phe Tyr Lys Ile Pro Ile Leu
100                 105                 110         
Val Ile Asn Lys Val Leu Pro Met Val Ser Ile Thr Leu Leu Ala Leu
115                 120                 125             
Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Val Gln Leu His Asn Gly
130                 135                 140                 
Thr Lys Tyr Lys Lys Phe Pro His Trp Leu Asp Lys Trp Met Leu Thr
145                 150                 155                 160 
Arg Lys Gln Phe Gly Leu Leu Ser Phe Phe Phe Ala Val Leu His Ala
165                 170                 175     
Ile Tyr Ser Leu Ser Tyr Pro Met Arg Arg Ser Tyr Arg Tyr Lys Leu
180                 185                 190         
Leu Asn Trp Ala Tyr Gln Gln Val Gln Gln Asn Lys Glu Asp Ala Trp
195                 200                 205             
Ile Glu His Asp Val Trp Arg Met Glu Ile Tyr Val Ser Leu Gly Ile
210                 215                 220                 
Val Gly Leu Ala Ile Leu Ala Leu Leu Ala Val Thr Ser Ile Pro Ser
225                 230                 235                 240 
Val Ser Asp Ser Leu Thr Trp Arg Glu Phe His Tyr Ile Gln Ser Lys
245                 250                 255     
Leu Gly Ile Val Ser Leu Leu Leu Gly Thr Ile His Ala Leu Ile Phe
260                 265                 270         
Ala Trp Asn Lys Trp Ile Asp Ile Lys Gln Phe Val Trp Tyr Thr Pro
275                 280                 285             
Pro Thr Phe Met Ile Ala Val Phe Leu Pro Ile Val Val Leu Ile Phe
290                 295                 300                 
Lys Ser Ile Leu Phe Leu Pro Cys Leu Arg Lys Lys Ile Leu Lys Ile
305                 310                 315                 320 
Arg His Gly Trp Glu Asp Val Thr Lys Ile Asn Lys Thr Glu Ile Cys
325                 330                 335     
Ser Gln Leu
<210> 38
<211> 488
<212> PRT
<213> Homo sapiens
<400> 38
Met Pro Glu Glu Met Asp Lys Pro Leu Ile Ser Leu His Leu Val Asp
1               5                  10                  15      
Ser Asp Ser Ser Leu Ala Lys Val Pro Asp Glu Ala Pro Lys Val Gly
20                  25                  30          
Ile Leu Gly Ser Gly Asp Phe Ala Arg Ser Leu Ala Thr Arg Leu Val
35                  40                  45              
Gly Ser Gly Phe Lys Val Val Val Gly Ser Arg Asn Pro Lys Arg Thr
50                  55                  60                  
Ala Arg Leu Tyr Pro Ser Ala Ala Gln Val Thr Phe Gln Glu Glu Ala
65                  70                  75                  80  
Val Ser Ser Pro Glu Val Ile Phe Val Ala Val Phe Arg Glu His Tyr
85                  90                  95      
Ser Ser Leu Cys Ser Leu Ser Asp Gln Leu Ala Gly Lys Ile Leu Val
100                 105                 110         
Asp Val Ser Asn Pro Thr Glu Gln Glu His Leu Gln His Arg Glu Ser
115                 120                 125             
Asn Ala Glu Tyr Leu Ala Ser Leu Phe Pro Thr Cys Thr Val Val Lys
130                 135                 140                 
Ala Phe Asn Val Ile Ser Ala Trp Thr Leu Gln Ala Gly Pro Arg Asp
145                 150                 155                 160 
Gly Asn Arg Gln Val Pro Ile Cys Gly Asp Gln Pro Glu Ala Lys Arg
165                 170                 175     
Ala Val Ser Glu Met Ala Leu Ala Met Gly Phe Met Pro Val Asp Met
180                 185                 190         
Gly Ser Leu Ala Ser Ala Trp Glu Val Glu Ala Met Pro Leu Arg Leu
195                 200                 205             
Leu Pro Ala Trp Lys Val Pro Thr Leu Leu Ala Leu Gly Leu Phe Val
210                 215                 220                 
Cys Phe Tyr Ala Tyr Asn Phe Val Arg Asp Val Leu Gln Pro Tyr Val
225                 230                 235                 240 
Gln Glu Ser Gln Asn Lys Phe Phe Lys Leu Pro Val Ser Val Val Asn
245                 250                 255     
Thr Thr Leu Pro Cys Val Ala Tyr Val Leu Leu Ser Leu Val Tyr Leu
260                 265                 270         
Pro Gly Val Leu Ala Ala Ala Leu Gln Leu Arg Arg Gly Thr Lys Tyr
275                 280                 285             
Gln Arg Phe Pro Asp Trp Leu Asp His Trp Leu Gln His Arg Lys Gln
290                 295                 300                 
Ile Gly Leu Leu Ser Phe Phe Cys Ala Ala Leu His Ala Leu Tyr Ser
305                 310                 315                 320 
Phe Cys Leu Pro Leu Arg Arg Ala His Arg Tyr Asp Leu Val Asn Leu
325                 330                 335     
Ala Val Lys Gln Val Leu Ala Asn Lys Ser His Leu Trp Val Glu Glu
340                 345                 350         
Glu Val Trp Arg Met Glu Ile Tyr Leu Ser Leu Gly Val Leu Ala Leu
355                 360                 365             
Gly Thr Leu Ser Leu Leu Ala Val Thr Ser Leu Pro Ser Ile Ala Asn
370                 375                 380                 
Ser Leu Asn Trp Arg Glu Phe Ser Phe Val Gln Ser Ser Leu Gly Phe
385                 390                 395                 400 
Val Ala Leu Val Leu Ser Thr Leu His Thr Leu Thr Tyr Gly Trp Thr
405                 410                 415     
Arg Ala Phe Glu Glu Ser Arg Tyr Lys Phe Tyr Leu Pro Pro Thr Phe
420                 425                 430         
Thr Leu Thr Leu Leu Val Pro Cys Val Val Ile Leu Ala Lys Ala Leu
435                 440                 445             
Phe Leu Leu Pro Cys Ile Ser Arg Arg Leu Ala Arg Ile Arg Arg Gly
450                 455                 460                 
Trp Glu Arg Glu Ser Thr Ile Lys Phe Thr Leu Pro Thr Asp His Ala
465                 470                 475                 480 
Leu Ala Glu Lys Thr Ser His Val
485             
<210> 39
<211> 283
<212> PRT
<213> Homo sapiens
<400> 39
Met Glu Lys Thr Cys Ile Asp Ala Leu Pro Leu Thr Met Asn Ser Ser
1               5                  10                  15      
Glu Lys Gln Glu Thr Val Cys Ile Phe Gly Thr Gly Asp Phe Gly Arg
20                  25                  30          
Ser Leu Gly Leu Lys Met Leu Gln Cys Gly Tyr Ser Val Val Phe Gly
35                  40                  45              
Ser Arg Asn Pro Gln Lys Thr Thr Leu Leu Pro Ser Gly Ala Glu Val
50                  55                  60                  
Leu Ser Tyr Ser Glu Ala Ala Lys Lys Ser Asp Ile Ile Ile Ile Ala
65                  70                  75                  80  
Ile His Arg Glu His Tyr Asp Phe Leu Thr Glu Leu Thr Glu Val Leu
85                  90                  95      
Asn Gly Lys Ile Leu Val Asp Ile Ser Asn Asn Leu Lys Ile Asn Gln
100                 105                 110         
Tyr Pro Glu Ser Asn Ala Glu Tyr Leu Ala His Leu Val Pro Gly Ala
115                 120                 125             
His Val Val Lys Ala Phe Asn Thr Ile Ser Ala Trp Ala Leu Gln Ser
130                 135                 140                 
Gly Ala Leu Asp Ala Ser Arg Gln Val Phe Val Cys Gly Asn Asp Ser
145                 150                 155                 160 
Lys Ala Lys Gln Arg Val Met Asp Ile Val Arg Asn Leu Gly Leu Thr
165                 170                 175     
Pro Met Asp Gln Gly Ser Leu Met Ala Ala Lys Glu Ile Glu Lys Tyr
180                 185                 190         
Pro Leu Gln Leu Phe Pro Met Trp Arg Phe Pro Phe Tyr Leu Ser Ala
195                 200                 205             
Val Leu Cys Val Phe Leu Phe Phe Tyr Cys Val Ile Arg Asp Val Ile
210                 215                 220                 
Tyr Pro Tyr Val Tyr Glu Lys Lys Asp Asn Thr Phe Arg Met Ala Ile
225                 230                 235                 240 
Ser Ile Pro Asn Arg Ile Phe Pro Ile Thr Ala Pro Tyr Thr Ala Cys
245                 250                 255     
Phe Gly Leu Pro Pro Trp Cys Tyr Cys Cys His Ser Thr Thr Val Pro
260                 265                 270         
Arg His Lys Ile Pro Ser Ile Pro Arg Leu Ala
275                 280             
<210> 40
<211> 1461
<212> DNA
<213> Homo sapiens
<400> 40
agcggcggct cctgcagcgg tggtcggctg ttgggtgtgg agtttcccag cgcccctcgg 60
gtccgaccct ttgagcgttc tgctccggcg ccagcctacc tcgctcctcg gcgccatgac 120
cacaaccacc accttcaagg gagtcgaccc caacagcagg aatagctccc gagttttgcg 180
gcctccaggt ggtggatcca atttttcatt aggttttgat gaaccaacag aacaacctgt 240
gaggaagaac aaaatggcct ctaatatctt tgggacacct gaagaaaatc aagcttcttg 300
ggccaagtca gcaggtgcca agtctagtgg tggcagggaa gacttggagt catctggact 360
gcagagaagg aactcctctg aagcaagctc cggagacttc ttagatctga agggagaagg 420
tgatattcat gaaaatgtgg acacagactt gccaggcagc ctggggcaga gtgaagagaa 480
gcccgtgcct gctgcgcctg tgcccagccc ggtggccccg gccccagtgc catccagaag 540
aaatccccct ggcggcaagt ccagcctcgt cttgggttag ctctgactgt cctgaacgct 600
gtcgttctgt ctgtttcctc catgcttgtg aactgcacaa cttgagcctg actgtacatc 660
tcttggattt gtttcattaa aaagaagcac tttatgtact gctgtctttt ttttttttct 720
tttgaagaac aggtttctct ctgtccttga ctcttgggtc tgtgggccat ggcatgagtg 780
ttttctagta gtagattgga gggaaagctt tgtgacactt agtactgtgt ttttaagaag 840
aaataatttg gttccagatg tgttagagga tcttttgtac tgaggttttt aacactttac 900
ttgggtttac caagcctcaa ctggacagac cataaacagt ccacaggcac cgttcctgcc 960
aggccccaac ccacagggag tctctccgca gagccttctt ggtgttgccc taacttgcca 1020
gtggcctttg ctcagagcct cctcctgtga catgtgaaca atgaagaggc ctgcgcctcc 1080
tgccttgccg cctgcaaagc aaagaaactg ccttttattt tttaacctta aaaagtagcc 1140
agatagtaac aagactggct ggctgatgag caaagccttt gctctcacgc agaggaaggc 1200
ttggatgtac aatgaaactg cctggaacta aaagcagtga agcaagggag gcaatcacac 1260
tgaagcgggt cttcctccag gaacggggtc ccacaggcgt gttgttttaa ataacctgat 1320
gctgtgtgca tgatgctggt gcttgaccat gaaaggaaag tctcatcctt aaaatgtgtt 1380
gtacttcaca atcctggact gttgcttcaa gtaaacaata tccacattct aaaaaaaaaa 1440
aaaaaaaaaa aaaaaaaaaa a                                           1461
<210> 41
<211> 154
<212> PRT
<213> Homo sapiens
<400> 41
Met Thr Thr Thr Thr Thr Phe Lys Gly Val Asp Pro Asn Ser Arg Asn
1               5                  10                  15      
Ser Ser Arg Val Leu Arg Pro Pro Gly Gly Gly Ser Asn Phe Ser Leu
20                  25                  30          
Gly Phe Asp Glu Pro Thr Glu Gln Pro Val Arg Lys Asn Lys Met Ala
35                  40                  45              
Ser Asn Ile Phe Gly Thr Pro Glu Glu Asn Gln Ala Ser Trp Ala Lys
50                  55                  60                  
Ser Ala Gly Ala Lys Ser Ser Gly Gly Arg Glu Asp Leu Glu Ser Ser
65                  70                  75                  80  
Gly Leu Gln Arg Arg Asn Ser Ser Glu Ala Ser Ser Gly Asp Phe Leu
85                  90                  95      
Asp Leu Lys Gly Glu Gly Asp Ile His Glu Asn Val Asp Thr Asp Leu
100                 105                 110         
Pro Gly Ser Leu Gly Gln Ser Glu Glu Lys Pro Val Pro Ala Ala Pro
115                 120                 125             
Val Pro Ser Pro Val Ala Pro Ala Pro Val Pro Ser Arg Arg Asn Pro
130                 135                 140                 
Pro Gly Gly Lys Ser Ser Leu Val Leu Gly
145                 150                 
<210> 42
<211> 50
<212> DNA
<213> Homo sapiens
<400> 42
tgaaaaccct ataaaggcgt cgatcggccg gacaggcggc agcggcggct            50
<210> 43
<211> 28
<212> DNA
<213> Homo sapiens
<400> 43
catgaccaca accaccacct tcaaggga                                    28
<210> 44
<211> 28
<212> DNA
<213> Homo sapiens
<400> 44
tgccattatt tgcagagttt tgcggcct                                    28
<210> 45
<211> 28
<212> DNA
<213> Homo sapiens
<400> 45
aaatcaagct tcttgggcca agtcagca                                    28
<210> 46
<211> 28
<212> DNA
<213> Homo sapiens
<400> 46
tattttgatt tttaggtgcc aagtctag                                    28
<210> 47
<211> 28
<212> DNA
<213> Homo sapiens
<400> 47
cttagatctg aaggtcagtg tgacagca                                    28
<210> 48
<211> 22
<212> DNA
<213> Homo sapiens
<400> 48
ttttttcttt tctagggaga ag                                          22
<210> 49
<211> 27
<212> DNA
<213> Homo sapiens
<400> 49
gtgatattca tggtaagtac ttctgaa                                     27
<210> 50
<211> 28
<212> DNA
<213> Homo sapiens
<400> 50
tccctgtttt catagaaaat gtggacac                                    28
<210> 51
<211> 3526
<212> DNA
<213> Homo sapiens
<400> 51
atgaccgacg cgctgttgcc cgcggccccc cagccgctgg agaaggagaa cgacggctac 60
tttcggaagg gctgtaatcc ccttgcacaa accggccgga gtaaattgca gaatcaaaga 120
gctgctttga atcagcagat cctgaaagcc gtgcggatga ggaccggagc ggaaaacctt 180
ctgaaagtgg ccacaaactc aaaggtgcgg gagcaagtgc ggctggagct gagcttcgtc 240
aactcagacc tgcagatgct caaggaagag ctggaggggc tgaacatctc ggtgggcgtc 300
tatcagaaca cagaggaggc atttacgatt cccctgattc ctcttggcct gaaggaaacg 360
aaagacgtcg actttgcagt cgtcctcaag gattttatcc tggaacatta cagtgaagat 420
ggctatttat atgaagatga aattgcagat cttatggatc tgagacaagc ttgtcggacg 480
cctagccggg atgaggccgg ggtggaactg ctgatgacat acttcatcca gctgggcttt 540
gtcgagagtc gattcttccc gcccacacgg cagatgggac tcctgttcac ctggtatgac 600
tctctcactg gggttccggt cagccagcag aacctgctgc tggagaaggc cagtgtcctg 660
ttcaacactg gggccctcta cacccagatt gggacccggt gcgatcggca gacgcaggct 720
gggctggaga gtgccataga tgcctttcag agagccgcag gggttttaaa ttacctgaaa 780
gacacattta cccatactcc aagttacgac atgagccctg ccatgctcag cgtgctcgtc 840
aaaatgatgc ttgcacaagc ccaagaaagc gtgtttgaga aaatcagcct tcctgggatc 900
cggaatgaat tcttcatgct ggtgaaggtg gctcaggagg ctgctaaggt gggagaggtc 960
taccaacagc tacacgcagc catgagccag gcgccggtga aagagaacat cccctactcc 1020
tgggccagct tagcctgcgt gaaggcccac cactacgcgg ccctggccca ctacttcact 1080
gccatcctcc tcatcgacca ccaggtgaag ccaggcacgg atctggacca ccaggagaag 1140
tgcctgtccc agctctacga ccacatgcca gaggggctga cacccttggc cacactgaag 1200
aatgatcagc agcgccgaca gctggggaag tcccacttgc gcagagccat ggctcatcac 1260
gaggagtcgg tgcgggaggc gagcctctgc aagaagctgc ggagcattga ggtgctacag 1320
aaggtgctgt gtgccgcaca ggaacgctcc cggctcacgt acgcccagca ccaggaggag 1380
gatgacctgc tgaacctgat cgacgccccc agtgttgttg ctaaaactga gcaagaggtt 1440
gacattatat tgccccagtt ctccaagctg acagtcacgg acttcttcca gaagctgggc 1500
cccttatctg tgttttcggc taacaagcgg tggacgcctc ctcgaagcat ccgcttcact 1560
gcagaagaag gggacttggg gttcaccttg agagggaacg cccccgttca ggttcacttc 1620
ctggatcctt actgctctgc ctcggtggca ggagcccggg aaggagatta tattgtctcc 1680
attcagcttg tggattgtaa gtggctgacg ctgagtgagg ttatgaagct gctgaagagc 1740
tttggcgagg acgagatcga gatgaaagtc gtgagcctcc tggactccac atcatccatg 1800
cataataaga gtgccacata ctccgtggga atgcagaaaa cgtactccat gatctgctta 1860
gccattgatg atgacgacaa aactgataaa accaagaaaa tctccaagaa gctttccttc 1920
ctgagttggg gcaccaacaa gaacagacag aagtcagcca gcaccttgtg cctcccatcg 1980
gtcggggctg cacggcctca ggtcaagaag aagctgccct cccctttcag ccttctcaac 2040
tcagacagtt cttggtacta atgtgaggaa acaaacatgt tcaggccccg aacatttccg 2100
gtgctgactc ggccttaaac gtttgtgcca taatggaaaa tatctatcta tctgttctca 2160
aatcctgttt ttctcatagt gtaaactcac atttgatgtg tttttatgaa ggaaagtaac 2220
caagaaacct ctaggaatta gtgaaaaaag aacttttttg aggtgtgtta ctatactgct 2280
gtaagttatt tattatataa agtattgtaa atagaatagt gttgaagata tgaaatatgg 2340
ctatttttaa tggtgacaat tatgactttt agtcactatt aaattggggt tacctatatc 2400
agtacaattt gtagttgttt ccaggtttgg ctaataatca ttccttaacc tagaattcag 2460
atgatcctgg aattaaggca ggtcagagga ctgtaatgat agaattaaat tagtgtcact 2520
aaaaactgtc ccaaagtgct gcttcctaat aggaattcat taacctaaaa caagatgtta 2580
ctattatatc gatagactat gaatgctatt tctagaaaaa gtctagtgcc aaatttgtct 2640
tattaaataa aaacaatgta ggagcagctt ttcttctagt ttgatgtcat ttaagaatta 2700
ctaacacagt ggcagtgtta gatgaagatg ctgtctacaa ggtagataat atactgtttg 2760
atactcaaaa catttttcat tttgtttaaa gtagaagtta cataattcta tattttaagt 2820
cttgggtaaa aaagtagttt tacattttat aaagtaaaga tgtaaatgat tcaggtttaa 2880
agctctattt gacttccttt ttttgtttga gatagcgtct tgctgtgttg cccaggctgg 2940
agtgcagtgg tgtgatctca gctcagtgca acctccgccc cctgggatca agcgattctc 3000
ctacctcagc ctcccaaata gctgggacta caaggtgccc tccagcatgc ctggctgatt 3060
tttgtatttt tagttgaggt gaggtttcac catgttggcc aggcgggttt cgaaatcctg 3120
acctcaaatg atccacccac ctcagcctcc caaagtgctg ggattacagg catgagccac 3180
cacaaccgtc ccactatttt actttttaaa atgacattcc tactgattga tttttatctt 3240
gctataagtt cgatgacacc gtgaatctaa taaggttcac tgttgacaca gtacaagtta 3300
catagctaaa atacatagca ttgaagacta attttaagga ttgacaagag tttattttct 3360
attgtgcaat atcttaaagg aagcaaccac ctttgggaaa gtgtatctgc tgctcctagg 3420
gccatgcttg tatacatatt taaataaaca tattcattta cccgaaaaaa aaaaaaaaaa 3480
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                3526
<210> 52
<211> 2100
<212> DNA
<213> Homo sapiens
<400> 52
atgaccgacg cgctgttgcc cgcggccccc cagccgctgg agaaggagaa cgacggctac 60
tttcggaagg gctgtaatcc ccttgcacaa accggccgga gtaaattgca gaatcaaaga 120
gctgctttga atcagcagat cctgaaagcc gtgcggatga ggaccggagc ggaaaacctt 180
ctgaaagtgg ccacaaactc aaaggtgcgg gagcaagtgc ggctggagct gagcttcgtc 240
aactcagacc tgcagatgct caaggaagag ctggaggggc tgaacatctc ggtgggcgtc 300
tatcagaaca cagaggaggc atttacgatt cccctgattc ctcttggcct gaaggaaacg 360
aaagacgtcg actttgcagt cgtcctcaag gattttatcc tggaacatta cagtgaagat 420
ggctatttat atgaagatga aattgcagat cttatggatc tgagacaagc ttgtcggacg 480
cctagccggg atgaggccgg ggtggaactg ctgatgacat acttcatcca gctgggcttt 540
gtcgagagtc gattcttccc gcccacacgg cagatgggac tcctgttcac ctggtatgac 600
tctctcactg gggttccggt cagccagcag aacctgctgc tggagaaggc cagtgtcctg 660
ttcaacactg gggccctcta cacccagatt gggacccggt gcgatcggca gacgcaggct 720
gggctggaga gtgccataga tgcctttcag agagccgcag gggttttaaa ttacctgaaa 780
gacacattta cccatactcc aagttacgac atgagccctg ccatgctcag cgtgctcgtc 840
aaaatgatgc ttgcacaagc ccaagaaagc gtgtttgaga aaatcagcct tcctgggatc 900
cggaatgaat tcttcatgct ggtgaaggtg gctcaggagg ctgctaaggt gggagaggtc 960
taccaacagc tacacgcagc catgagccag gcgccggtga aagagaacat cccctactcc 1020
tgggccagct tagcctgcgt gaaggcccac cactacgcgg ccctggccca ctacttcact 1080
gccatcctcc tcatcgacca ccaggtgaag ccaggcacgg atctggacca ccaggagaag 1140
tgcctgtccc agctctacga ccacatgcca gaggggctga cacccttggc cacactgaag 1200
aatgatcagc agcgccgaca gctggggaag tcccacttgc gcagagccat ggctcatcac 1260
gaggagtcgg tgcgggaggc gagcctctgc aagaagctgc ggagcattga ggtgctacag 1320
aaggtgctgt gtgccgcaca ggaacgctcc cggctcacgt acgcccagca ccaggaggag 1380
gatgacctgc tgaacctgat cgacgccccc agtgttgttg ctaaaactga gcaagaggtt 1440
gacattatat tgccccagtt ctccaagctg acagtcacgg acttcttcca gaagctgggc 1500
cccttatctg tgttttcggc taacaagcgg tggacgcctc ctcgaagcat ccgcttcact 1560
gcagaagaag gggacttggg gttcaccttg agagggaacg cccccgttca ggttcacttc 1620
ctggatcctt actgctctgc ctcggtggca ggagcccggg aaggagatta tattgtctcc 1680
attcagcttg tggattgtaa gtggctgacg ctgagtgagg ttatgaagct gctgaagagc 1740
tttggcgagg acgagatcga gatgaaagtc gtgagcctcc tggactccac atcatccatg 1800
cataataaga gtgccacata ctccgtggga atgcagaaaa cgtactccat gatctgctta 1860
gccattgatg atgacgacaa aactgataaa accaagaaaa tctccaagaa gctttccttc 1920
ctgagttggg gcaccaacaa gaacagacag aagtcagcca gcaccttgtg cctcccatcg 1980
gtcggggctg cacggcctca ggtcaagaag aagctgccct cccctttcag ccttctcaac 2040
tcagacagtt cttggtacta atgtgaggaa acaaacatgt tcaggccccg aacatttccg 2100
<210> 53
<211> 686
<212> PRT
<213> Homo sapiens
<400> 53
Met Thr Asp Ala Leu Leu Pro Ala Ala Pro Gln Pro Leu Glu Lys Glu
1               5                  10                  15      
Asn Asp Gly Tyr Phe Arg Lys Gly Cys Asn Pro Leu Ala Gln Thr Gly
20                  25                  30          
Arg Ser Lys Leu Gln Asn Gln Arg Ala Ala Leu Asn Gln Gln Ile Leu
35                  40                  45              
Lys Ala Val Arg Met Arg Thr Gly Ala Glu Asn Leu Leu Lys Val Ala
50                  55                  60                  
Thr Asn Ser Lys Val Arg Glu Gln Val Arg Leu Glu Leu Ser Phe Val
65                  70                  75                  80  
Asn Ser Asp Leu Gln Met Leu Lys Glu Glu Leu Glu Gly Leu Asn Ile
85                  90                  95      
Ser Val Gly Val Tyr Gln Asn Thr Glu Glu Ala Phe Thr Ile Pro Leu
100                 105                 110         
Ile Pro Leu Gly Leu Lys Glu Thr Lys Asp Val Asp Phe Ala Val Val
115                 120                 125             
Leu Lys Asp Phe Ile Leu Glu His Tyr Ser Glu Asp Gly Tyr Leu Tyr
130                 135                 140                 
Glu Asp Glu Ile Ala Asp Leu Met Asp Leu Arg Gln Ala Cys Arg Thr
145                 150                 155                 160 
Pro Ser Arg Asp Glu Ala Gly Val Glu Leu Leu Met Thr Tyr Phe Ile
165                 170                 175     
Gln Leu Gly Phe Val Glu Ser Arg Phe Phe Pro Pro Thr Arg Gln Met
180                 185                 190         
Gly Leu Leu Phe Thr Trp Tyr Asp Ser Leu Thr Gly Val Pro Val Ser
195                 200                 205             
Gln Gln Asn Leu Leu Leu Glu Lys Ala Ser Val Leu Phe Asn Thr Gly
210                 215                 220                 
Ala Leu Tyr Thr Gln Ile Gly Thr Arg Cys Asp Arg Gln Thr Gln Ala
225                 230                 235                 240 
Gly Leu Glu Ser Ala Ile Asp Ala Phe Gln Arg Ala Ala Gly Val Leu
245                 250                 255     
Asn Tyr Leu Lys Asp Thr Phe Thr His Thr Pro Ser Tyr Asp Met Ser
260                 265                 270         
Pro Ala Met Leu Ser Val Leu Val Lys Met Met Leu Ala Gln Ala Gln
275                 280                 285             
Glu Ser Val Phe Glu Lys Ile Ser Leu Pro Gly Ile Arg Asn Glu Phe
290                 295                 300                 
Phe Met Leu Val Lys Val Ala Gln Glu Ala Ala Lys Val Gly Glu Val
305                 310                 315                 320 
Tyr Gln Gln Leu His Ala Ala Met Ser Gln Ala Pro Val Lys Glu Asn
325                 330                 335     
Ile Pro Tyr Ser Trp Ala Ser Leu Ala Cys Val Lys Ala His His Tyr
340                 345                 350         
Ala Ala Leu Ala His Tyr Phe Thr Ala Ile Leu Leu Ile Asp His Gln
355                 360                 365             
Val Lys Pro Gly Thr Asp Leu Asp His Gln Glu Lys Cys Leu Ser Gln
370                 375                 380                 
Leu Tyr Asp His Met Pro Glu Gly Leu Thr Pro Leu Ala Thr Leu Lys
385                 390                 395                 400 
Asn Asp Gln Gln Arg Arg Gln Leu Gly Lys Ser His Leu Arg Arg Ala
405                 410                 415     
Met Ala His His Glu Glu Ser Val Arg Glu Ala Ser Leu Cys Lys Lys
420                 425                 430         
Leu Arg Ser Ile Glu Val Leu Gln Lys Val Leu Cys Ala Ala Gln Glu
435                 440                 445             
Arg Ser Arg Leu Thr Tyr Ala Gln His Gln Glu Glu Asp Asp Leu Leu
450                 455                 460                 
Asn Leu Ile Asp Ala Pro Ser Val Val Ala Lys Thr Glu Gln Glu Val
465                 470                 475                 480 
Asp Ile Ile Leu Pro Gln Phe Ser Lys Leu Thr Val Thr Asp Phe Phe
485                 490                 495     
Gln Lys Leu Gly Pro Leu Ser Val Phe Ser Ala Asn Lys Arg Trp Thr
500                 505                 510         
Pro Pro Arg Ser Ile Arg Phe Thr Ala Glu Glu Gly Asp Leu Gly Phe
515                 520                 525             
Thr Leu Arg Gly Asn Ala Pro Val Gln Val His Phe Leu Asp Pro Tyr
530                 535                 540                 
Cys Ser Ala Ser Val Ala Gly Ala Arg Glu Gly Asp Tyr Ile Val Ser
545                 550                 555                 560 
Ile Gln Leu Val Asp Cys Lys Trp Leu Thr Leu Ser Glu Val Met Lys
565                 570                 575     
Leu Leu Lys Ser Phe Gly Glu Asp Glu Ile Glu Met Lys Val Val Ser
580                 585                 590         
Leu Leu Asp Ser Thr Ser Ser Met His Asn Lys Ser Ala Thr Tyr Ser
595                 600                 605             
Val Gly Met Gln Lys Thr Tyr Ser Met Ile Cys Leu Ala Ile Asp Asp
610                 615                 620                 
Asp Asp Lys Thr Asp Lys Thr Lys Lys Ile Ser Lys Lys Leu Ser Phe
625                 630                 635                 640 
Leu Ser Trp Gly Thr Asn Lys Asn Arg Gln Lys Ser Ala Ser Thr Leu
645                 650                 655     
Cys Leu Pro Ser Val Gly Ala Ala Arg Pro Gln Val Lys Lys Lys Leu
660                 665                 670         
Pro Ser Pro Phe Ser Leu Leu Asn Ser Asp Ser Ser Trp Tyr
675                 680                 685     
<210> 54
<211> 50
<212> DNA
<213> Homo sapiens
<400> 54
aaaaaaaata aataaaaagg ccgggcgcgt tggcccgcgc ctgcagcccc            50
<210> 55
<211> 869
<212> DNA
<213> Homo sapiens
<400> 55
tgctacttgg gaggctgagg ctggagcatc gcttgatcct gggaggtcga ggctgcaaag 60
agtcgagatc gcaacactgc tctccagcct gggcgacaga gcgaggtccc atctcttaaa 120
aaaaagaact gtgctcaagg acatctgccg tgtctggggc gcaaaacccc tcctggtccc 180
ctctctcagg gcagtccgcg agcccagcgg atcccactcg tctttgcagc gcggacaggg 240
aatcggctga gttgatccca tgccaacaag cccgagtagt ccgggcaagg cgctcggcgg 300
ggcagtcaac gctccctccg ccatgggctc ccctcttggg aaaagctttt ccaaaccgcc 360
gggcccaggg cccagagctc ccgccgcgcc ctcgacgtgg cgtcgagtct ggccccttcc 420
cccgcggcgc acgggcttca cccaggaggg acgcgcctgg atccacgcct tcctcactga 480
ctccccgggc tccagggcag ggtgcaggtc cacagccagg gcttcgctgc ggcccctgag 540
accccagtgc ctttcctgcg ctctcgcggc actcgcaaag ttgagtcagc cacgacgccc 600
acagacaacc ccgaggcgcc gcgcccaggg cgcagctctc cgggtgacga gcgcctcaag 660
gggcgcgggt tcggggcccg cgacggggcg gggcgcgtct ccagggctcc agtgctcggc 720
ctcaggcggg gctagaaggg ccgcgggacg gggtgggagt ggaggggcgg ggaagggcgg 780
ggacaggggc ggggccgcac gtcctctcgg gccagcctca gccgccgcgc ctcagtccgc 840
cgtccgccct ccgcgcccgc gccgctagc                                   869
<210> 56
<211> 69
<212> DNA
<213> Homo sapiens
<400> 56
atgaccgacg cgctgttgcc cgcggccccc cagccgctgg agaaggagaa cgacggctac 60
tttcggaag                                                         69
<210> 57
<211> 117
<212> DNA
<213> Homo sapiens
<400> 57
ggctgtaatc cccttgcaca aaccggccgg agtaaattgc agaatcaaag agctgctttg 60
aatcagcaga tcctgaaagc cgtgcggatg aggaccggag cggaaaacct tctgaaa    117
<210> 58
<211> 129
<212> DNA
<213> Homo sapiens
<400> 58
gtggccacaa actcaaaggt gcgggagcaa gtgcggctgg agctgagctt cgtcaactca 60
gacctgcaga tgctcaagga agagctggag gggctgaaca tctcggtggg cgtctatcag 120
aacacagag                                                         129
<210> 59
<211> 75
<212> DNA
<213> Homo sapiens
<400> 59
gaggcattta cgattcccct gattcctctt ggcctgaagg aaacgaaaga cgtcgacttt 60
gcagtcgtcc tcaag                                                  75
<210> 60
<211> 79
<212> DNA
<213> Homo sapiens
<400> 60
gattttatcc tggaacatta cagtgaagat ggctatttat atgaagatga aattgcagat 60
cttatggatc tgagacaag                                              79
<210> 61
<211> 124
<212> DNA
<213> Homo sapiens
<400> 61
cttgtcggac gcctagccgg gatgaggccg gggtggaact gctgatgaca tacttcatcc 60
agctgggctt tgtcgagagt cgattcttcc cgcccacacg gcagatggga ctcctgttca 120
cctg                                                              124
<210> 62
<211> 167
<212> DNA
<213> Homo sapiens
<400> 62
gtatgactct ctcactgggg ttccggtcag ccagcagaac ctgctgctgg agaaggccag 60
tgtcctgttc aacactgggg ccctctacac ccagattggg acccggtgcg atcggcagac 120
gcaggctggg ctggagagtg ccatagatgc ctttcagaga gccgcag               167
<210> 63
<211> 188
<212> DNA
<213> Homo sapiens
<400> 63
gggttttaaa ttacctgaaa gacacattta cccatactcc aagttacgac atgagccctg 60
ccatgctcag cgtgctcgtc aaaatgatgc ttgcacaagc ccaagaaagc gtgtttgaga 120
aaatcagcct tcctgggatc cggaatgaat tcttcatgct ggtgaaggtg gctcaggagg 180
ctgctaag                                                          188
<210> 64
<211> 156
<212> DNA
<213> Homo sapiens
<400> 64
gtgggagagg tctaccaaca gctacacgca gccatgagcc aggcgccggt gaaagagaac 60
atcccctact cctgggccag cttagcctgc gtgaaggccc accactacgc ggccctggcc 120
cactacttca ctgccatcct cctcatcgac caccag                           156
<210> 65
<211> 120
<212> DNA
<213> Homo sapiens
<400> 65
gtgaagccag gcacggatct ggaccaccag gagaagtgcc tgtcccagct ctacgaccac 60
atgccagagg ggctgacacc cttggccaca ctgaagaatg atcagcagcg ccgacagctg 120
<210> 66
<211> 196
<212> DNA
<213> Homo sapiens
<400> 66
gggaagtccc acttgcgcag agccatggct catcacgagg agtcggtgcg ggaggcgagc 60
ctctgcaaga agctgcggag cattgaggtg ctacagaagg tgctgtgtgc cgcacaggaa 120
cgctcccggc tcacgtacgc ccagcaccag gaggaggatg acctgctgaa cctgatcgac 180
gcccccagtg ttgttg                                                 196
<210> 67
<211> 77
<212> DNA
<213> Homo sapiens
<400> 67
ctaaaactga gcaagaggtt gacattatat tgccccagtt ctccaagctg acagtcacgg 60
acttcttcca gaagctg                                                77
<210> 68
<211> 147
<212> DNA
<213> Homo sapiens
<400> 68
ggccccttat ctgtgttttc ggctaacaag cggtggacgc ctcctcgaag catccgcttc 60
actgcagaag aaggggactt ggggttcacc ttgagaggga acgcccccgt tcaggttcac 120
ttcctggatc cttactgctc tgcctcg                                     147
<210> 69
<211> 156
<212> DNA
<213> Homo sapiens
<400> 69
gtggcaggag cccgggaagg agattatatt gtctccattc agcttgtgga ttgtaagtgg 60
ctgacgctga gtgaggttat gaagctgctg aagagctttg gcgaggacga gatcgagatg 120
aaagtcgtga gcctcctgga ctccacatca tccatg                           156
<210> 70
<211> 1726
<212> DNA
<213> Homo sapiens
<400> 70
cataataaga gtgccacata ctccgtggga atgcagaaaa cgtactccat gatctgctta 60
gccattgatg atgacgacaa aactgataaa accaagaaaa tctccaagaa gctttccttc 120
ctgagttggg gcaccaacaa gaacagacag aagtcagcca gcaccttgtg cctcccatcg 180
gtcggggctg cacggcctca ggtcaagaag aagctgccct cccctttcag ccttctcaac 240
tcagacagtt cttggtacta atgtgaggaa acaaacatgt tcaggccccg aacatttccg 300
gtgctgactc ggccttaaac gtttgtgcca taatggaaaa tatctatcta tctgttctca 360
aatcctgttt ttctcatagt gtaaactcac atttgatgtg tttttatgaa ggaaagtaac 420
caagaaacct ctaggaatta gtgaaaaaag aacttttttg aggtgtgtta ctatactgct 480
gtaagttatt tattatataa agtattgtaa atagaatagt gttgaagata tgaaatatgg 540
ctatttttaa tggtgacaat tatgactttt agtcactatt aaattggggt tacctatatc 600
agtacaattt gtagttgttt ccaggtttgg ctaataatca ttccttaacc tagaattcag 660
atgatcctgg aattaaggca ggtcagagga ctgtaatgat agaattaaat tagtgtcact 720
aaaaactgtc ccaaagtgct gcttcctaat aggaattcat taacctaaaa caagatgtta 780
ctattatatc gatagactat gaatgctatt tctagaaaaa gtctagtgcc aaatttgtct 840
tattaaataa aaacaatgta ggagcagctt ttcttctagt ttgatgtcat ttaagaatta 900
ctaacacagt ggcagtgtta gatgaagatg ctgtctacaa ggtagataat atactgtttg 960
atactcaaaa catttttcat tttgtttaaa gtagaagtta cataattcta tattttaagt 1020
cttgggtaaa aaagtagttt tacattttat aaagtaaaga tgtaaatgat tcaggtttaa 1080
agctctattt gacttccttt ttttgtttga gatagcgtct tgctgtgttg cccaggctgg 1140
agtgcagtgg tgtgatctca gctcagtgca acctccgccc cctgggatca agcgattctc 1200
ctacctcagc ctcccaaata gctgggacta caaggtgccc tccagcatgc ctggctgatt 1260
tttgtatttt tagttgaggt gaggtttcac catgttggcc aggcgggttt cgaaatcctg 1320
acctcaaatg atccacccac ctcagcctcc caaagtgctg ggattacagg catgagccac 1380
cacaaccgtc ccactatttt actttttaaa atgacattcc tactgattga tttttatctt 1440
gctataagtt cgatgacacc gtgaatctaa taaggttcac tgttgacaca gtacaagtta 1500
catagctaaa atacatagca ttgaagacta attttaagga ttgacaagag tttattttct 1560
attgtgcaat atcttaaagg aagcaaccac ctttgggaaa gtgtatctgc tgctcctagg 1620
gccatgcttg tatacatatt taaataaaca tattcattta cccgaaaaaa aaaaaaaaaa 1680
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                1726
<210> 71
<211> 643
<212> PRT
<213> Mus musculus
<400> 71
Met Ile Leu Glu Glu Arg Pro Asp Gly Gln Gly Thr Gly Glu Glu Ser
1               5                  10                  15      
Ser Arg Pro Gln Asp Asp Gly Ser Ile Arg Lys Gly Tyr Gly Ser Phe
20                  25                  30          
Val Gln Asn Gln Pro Gly Gln Leu Gln Ser His Arg Ala Arg Leu His
35                  40                  45              
Gln Gln Ile Ser Lys Glu Leu Arg Met Arg Thr Gly Ala Glu Asn Leu
50                  55                  60                  
Tyr Arg Ala Thr Ser Asn Thr Trp Val Arg Glu Thr Val Ala Leu Glu
65                  70                  75                  80  
Leu Ser Tyr Val Asn Ser Asn Leu Gln Leu Leu Lys Glu Glu Leu Ala
85                  90                  95      
Glu Leu Ser Thr Ser Val Asp Val Asp Gln Pro Glu Gly Glu Gly Ile
100                 105                 110         
Thr Ile Pro Met Ile Pro Leu Gly Leu Lys Glu Thr Lys Glu Leu Asp
115                 120                 125             
Trp Ala Thr Pro Leu Lys Glu Leu Ile Ser Glu His Phe Gly Glu Asp
130                 135                 140                 
Gly Thr Ser Phe Glu Thr Glu Ile Gln Glu Leu Glu Asp Leu Arg Gln
145                 150                 155                 160 
Ala Thr Arg Thr Pro Ser Arg Asp Glu Ala Gly Leu Asp Leu Leu Ala
165                 170                 175     
Ala Tyr Tyr Ser Gln Leu Cys Phe Leu Asp Ala Arg Phe Phe Ser Pro
180                 185                 190         
Ser Arg Ser Pro Gly Leu Leu Phe His Trp Tyr Asp Ser Leu Thr Gly
195                 200                 205             
Val Pro Ala Gln Gln Arg Ala Leu Ala Phe Glu Lys Gly Ser Val Leu
210                 215                 220                 
Phe Asn Ile Gly Ala Leu His Thr Gln Ile Gly Ala Arg Gln Asp Cys
225                 230                 235                 240 
Ser Cys Thr Glu Gly Thr Asn His Ala Ala Glu Ala Phe Gln Arg Ala
245                 250                 255     
Ala Gly Ala Phe Arg Leu Leu Arg Glu Asn Phe Ser His Ala Pro Ser
260                 265                 270         
Pro Asp Met Ser Ala Ala Ser Leu Ser Met Leu Glu Gln Leu Met Ile
275                 280                 285             
Ala Gln Ala Gln Glu Cys Ile Phe Lys Gly Leu Leu Leu Pro Ala Ser
290                 295                 300                 
Ala Thr Pro Asp Ile Cys Pro Asp Gln Leu Gln Leu Ala Gln Glu Ala
305                 310                 315                 320 
Ala Gln Val Ala Thr Glu Tyr Gly Leu Val His Arg Ala Met Ala Gln
325                 330                 335     
Pro Pro Val Arg Asp Tyr Leu Pro Ala Ser Trp Thr Asn Leu Ala His
340                 345                 350         
Val Lys Ala Glu His Phe Cys Ala Leu Ala His Tyr His Ala Ala Met
355                 360                 365             
Ala Leu Cys Glu Ser His Pro Ala Lys Gly Glu Leu Ala Arg Gln Glu
370                 375                 380                 
His Val Phe Gln Pro Ser Thr Pro His Glu Pro Leu Gly Pro Thr Leu
385                 390                 395                 400 
Pro Gln His Pro Glu Asp Arg Arg Lys Leu Ala Lys Ala His Leu Lys
405                 410                 415     
Arg Ala Ile Leu Gly Gln Glu Glu Ala Leu Arg Leu His Thr Leu Cys
420                 425                 430         
Arg Val Leu Arg Lys Val Asp Leu Leu Gln Val Val Val Thr Gln Ala
435                 440                 445             
Leu Arg Arg Ser Leu Ala Lys Tyr Ser Gln Leu Glu Arg Glu Asp Asp
450                 455                 460                 
Phe Phe Glu Ala Thr Glu Ala Pro Asp Ile Gln Pro Lys Thr His Gln
465                 470                 475                 480 
Thr Pro Glu Gly Pro Leu Ser Val Phe Ser Thr Lys Asn Arg Trp Gln
485                 490                 495     
Leu Val Gly Pro Val His Met Thr Arg Gly Glu Gly Gly Phe Gly Phe
500                 505                 510         
Thr Leu Arg Gly Asp Ser Pro Val Leu Ile Ala Ala Val Val Pro Gly
515                 520                 525             
Gly Gln Ala Glu Ser Ala Gly Leu Lys Glu Gly Asp Tyr Ile Val Ser
530                 535                 540                 
Val Asn Gly Gln Pro Cys Lys Trp Trp Lys His Leu Glu Val Val Thr
545                 550                 555                 560 
Gln Leu Arg Ser Met Gly Glu Glu Gly Val Ser Leu Gln Val Val Ser
565                 570                 575     
Leu Leu Pro Ser Pro Glu Pro Arg Gly Thr Gly Pro Arg Arg Ala Ala
580                 585                 590         
Leu Leu Trp Asn Gln Arg Glu Cys Gly Phe Glu Thr Pro Met Pro Thr
595                 600                 605             
Arg Thr Arg Pro Trp Pro Ile Leu Gly Trp Ser Arg Lys Asn Lys Gln
610                 615                 620                 
Gly Lys Thr Gly Ser His Pro Asp Pro Cys Thr Asn Arg Asn Cys Val
625                 630                 635                 640 
Thr Cys Pro
<210> 72
<211> 718
<212> PRT
<213> Drosophila melanogaster
<400> 72
Met Asp Glu Lys Glu His Glu Leu Ser Thr Arg Val Val Lys Asn Glu
1               5                  10                  15      
Glu Asn Glu Asp Asp Glu Lys Leu Asn Glu Leu Ser Phe Cys Phe Val
20                  25                  30          
Arg Gly Ser Asp Pro Arg Ala Ala Thr Cys Arg Ser Lys Leu Gln Asn
35                  40                  45              
Arg Arg Cys Lys Leu Asn Lys Glu Ile Asn Lys Glu Leu Arg Leu Arg
50                  55                  60                  
Ala Gly Ala Glu Asn Leu Tyr Lys Ala Thr Ser Asn Arg Lys Leu Arg
65                  70                  75                  80  
Asp Thr Val Ala Leu Glu Leu Ser Phe Val Asn Ser Asn Leu Gln Leu
85                  90                  95      
Leu Lys Glu Gln Leu Ala Glu Leu Asn Ser Ser Val Glu Ile Tyr Gln
100                 105                 110         
Ser Glu Ser His Asn Gly Ile Met Pro Met Ile Pro Leu Gly Leu Lys
115                 120                 125             
Glu Thr Lys Glu Ile Asn Phe Met Glu Pro Phe Ser Asp Phe Ile Leu
130                 135                 140                 
Glu His Tyr Ser Glu Glu Pro Ser Met Tyr Ile Asp Ala Ile Ala Asp
145                 150                 155                 160 
Met Thr Asp Thr Arg Gln Ala Ser Lys Thr Pro Ser Arg Asp Ala Leu
165                 170                 175     
Gly Val Ala Leu Leu Phe Arg Tyr Tyr Asn Thr Leu Tyr Tyr Val Glu
180                 185                 190         
Arg Arg Phe Phe Pro Pro Asp Arg Asn Leu Gly Val Tyr Phe Glu Trp
195                 200                 205             
Tyr Asp Ser Leu Thr Gly Val Pro Ser Cys Gln Arg Thr Ile Ala Phe
210                 215                 220                 
Glu Lys Ala Cys Thr Leu Phe Asn Leu Gly Gly Ile Tyr Thr Gln Ile
225                 230                 235                 240 
Gly Ala Arg His Asp Arg Thr Thr Glu Arg Gly Leu Asp Leu Ala Val
245                 250                 255     
Asp Ser Phe Leu Arg Ala Ala Gly Val Phe Arg His Ile Tyr Asp Thr
260                 265                 270         
Phe Thr Asn Ala Pro Ser Met Asp Leu Lys Pro Gln Val Leu Asp Val
275                 280                 285             
Leu Val Ser Leu Met Leu Ser Gln Ala Arg Glu Cys Leu Phe Glu Lys
290                 295                 300                 
Leu Gln Leu Gln Ile Glu Ala Met Ser His Asp Cys Gln Ala Phe Arg
305                 310                 315                 320 
Asp Leu Ala Gly Glu Ala Ala Gln Ile Ser His Glu Tyr Asn Glu Met
325                 330                 335     
His Lys Asn Ile Gln Ala Asn Asp Thr His Thr Tyr Leu Pro Glu Cys
340                 345                 350         
Trp Ala Gly Leu Val Pro Val Lys Ala Glu Leu Tyr Lys Ala Phe Ala
355                 360                 365             
His Phe Tyr Lys Ala Arg Ser Ile Asp Ala Thr Asp Glu Leu Lys Ala
370                 375                 380                 
Ser Lys Ser Ser Gln Lys Asn Gln Glu Ser Phe Ile Gly Asn Ser Gln
385                 390                 395                 400 
Glu Val Glu Arg Ile Thr Thr Ala Asp Tyr Gly Ala Ser Asp Glu Ala
405                 410                 415     
Ser Thr Ser Ile Ala Asn Lys Leu Ala His Leu Lys Glu Ala Leu Ala
420                 425                 430         
Ser Ile Glu Glu Ala Gln Arg Leu Gln Arg Met Cys Arg Phe Leu Lys
435                 440                 445             
Asn Lys Ala Ser Leu Thr Glu Val Met Lys Glu Val His Ser Lys Ser
450                 455                 460                 
Gln Glu Glu Leu Glu Lys Phe Arg Leu Gln Ala Ser Ala Lys Asn Ile
465                 470                 475                 480 
Glu Asp Gly Asp Leu Leu Glu Arg Ser Val Glu Ala Ser Ser Lys Phe
485                 490                 495     
Thr Leu Ser Leu Thr Gly Pro Asp Phe Thr Ser His Lys Val Lys Asp
500                 505                 510         
Pro Phe Lys Arg Leu Gly Pro Ile Ala Ile Phe Ser Ala Arg Arg His
515                 520                 525             
Trp Thr Ala Pro Arg Cys Val Arg Leu Gln Lys Gly Ser Ser Leu Tyr
530                 535                 540                 
His Ser Val Pro Ser Asn Asp Asn Lys Cys Pro Leu Asp Asn Asp Asp
545                 550                 555                 560 
Asp Glu Glu His Asp Gly Gly Tyr Asn Leu Tyr Lys Glu Glu Phe Glu
565                 570                 575     
Asn Phe Gly Phe His Val Arg Gly Asp Ala Pro Val Ile Ile Ala His
580                 585                 590         
Val Glu Ile Asn Ser Leu Ala Asp Leu Gly Gly Ile Lys Glu Gly Asp
595                 600                 605             
Phe Ile Val Glu Ile Ala Gly Val Asp Val Lys Trp Tyr Ser His Gln
610                 615                 620                 
Gln Val Val Gln Leu Ile Gln Ser Cys Gly Ser Thr Leu Glu Leu Arg
625                 630                 635                 640 
Val Ile Thr Pro Met Asp Arg Asn Tyr Leu Lys Pro Leu Ser Ser Lys
645                 650                 655     
Gly Ser Leu Ser Thr Leu Ser Ala Ala Ser Ser Ser Gly Ile Ser Ser
660                 665                 670         
Gly Phe Pro Ser Pro Thr Ser Ile Ala Ala Lys Pro Lys Leu His Leu
675                 680                 685             
Lys Thr Ser Ser Ser Ser Arg Pro Ala Gly Ser Val Ser Ser Ser Ser
690                 695                 700                 
Trp Asn Pro Phe Arg Arg Thr Pro Ser Leu Ala Lys Ile Phe
705                 710                 715             
<210> 73
<211> 686
<212> PRT
<213> Mus musculus
<400> 73
Met Thr Asp Thr Leu Leu Pro Ala Ala Pro Gln Pro Leu Glu Lys Glu
1               5                  10                  15      
Gly Asp Asp Tyr Phe Arg Lys Gly Cys Asn Pro Leu Ala Gln Thr Gly
20                  25                  30          
Arg Ser Lys Leu Gln Asn Gln Arg Ala Ala Leu Asn Gln Gln Ile Leu
35                  40                  45              
Lys Ala Val Arg Met Arg Thr Gly Ala Glu Asn Leu Leu Lys Val Ala
50                  55                  60                  
Thr Asn Gln Lys Val Arg Glu Gln Val Arg Leu Glu Leu Ser Phe Val
65                  70                  75                  80  
Asn Ser Asp Leu Gln Met Leu Lys Glu Glu Leu Glu Gly Leu Asn Ile
85                  90                  95      
Ser Val Gly Val Tyr Gln Gly Thr Glu Glu Ala Phe Thr Ile Pro Leu
100                 105                 110         
Ile Pro Leu Gly Leu Lys Glu Thr Lys Glu Val Asp Phe Ser Ile Val
115                 120                 125             
Phe Lys Asp Phe Ile Leu Glu His Tyr Ser Glu Asp Ser Tyr Leu Tyr
130                 135                 140                 
Glu Asp Asp Ile Ala Asp Leu Met Asp Leu Arg Gln Ala Cys Arg Thr
145                 150                 155                 160 
Pro Ser Arg Asp Glu Ala Gly Val Glu Leu Leu Met Ser Tyr Phe Ile
165                 170                 175     
Gln Leu Gly Phe Val Glu Ser Arg Phe Phe Pro Pro Thr Arg His Met
180                 185                 190         
Gly Leu Leu Phe Thr Trp Tyr Asp Ser Phe Thr Gly Val Pro Val Ser
195                 200                 205             
Gln Gln Thr Leu Leu Leu Glu Lys Ala Ser Val Leu Phe Asn Ile Gly
210                 215                 220                 
Ala Leu Tyr Thr Gln Ile Gly Thr Arg Cys Asn Arg Gln Thr Gln Ala
225                 230                 235                 240 
Gly Leu Glu Ser Ala Val Asp Ala Phe Gln Arg Ala Ala Gly Val Leu
245                 250                 255     
Asn Tyr Leu Lys Glu Thr Phe Thr His Thr Pro Ser Tyr Asp Met Ser
260                 265                 270         
Pro Ala Met Leu Ser Val Leu Val Lys Met Met Leu Ala Gln Ala Gln
275                 280                 285             
Glu Ser Val Phe Glu Lys Val Cys Leu Pro Gly Ile Gln Asn Glu Phe
290                 295                 300                 
Phe Val Leu Val Lys Val Ala Gln Glu Ala Ala Lys Val Ala Glu Ala
305                 310                 315                 320 
Tyr Arg Gln Leu His Ala Ala Met Ser Gln Glu Pro Val Lys Glu Asn
325                 330                 335     
Ile Pro Tyr Ser Trp Ala Ser Val Ala Tyr Val Lys Ala Tyr His Tyr
340                 345                 350         
Gly Ala Leu Ala His Tyr Phe Ala Ala Thr Leu Leu Ile Asp His Gln
355                 360                 365             
Leu Lys Pro Gly Ala Asp Glu Asp His Gln Glu Lys Cys Leu Ser Gln
370                 375                 380                 
Leu Tyr Asp Arg Met Pro Glu Gly Met Thr Pro Leu Ala Thr Leu Lys
385                 390                 395                 400 
Asn Ala Gly Gln Arg Val Leu Leu Gly Lys Gly His Leu His Arg Ala
405                 410                 415     
Ile Gly Phe His Glu Glu Ser Leu Arg Glu Ala Asn Leu Cys Lys Lys
420                 425                 430         
Leu Arg Asp Ile Gln Val Leu Arg Asp Val Leu Ser Ala Ala His Gln
435                 440                 445             
Arg Thr Gln Leu Lys His Thr Gln His Arg Glu Asp Asp Asp Leu Leu
450                 455                 460                 
Asn Leu Ile Asp Ala Pro Asp Val Leu Pro Lys Thr Glu Arg Glu Val
465                 470                 475                 480 
Lys Ile Thr Phe Pro Asp Phe Ser Lys Val Thr Val Thr Asp Phe Phe
485                 490                 495     
Gln Lys Leu Gly Pro Leu Ser Val Phe Ser Ala Ser Lys Arg Trp Ser
500                 505                 510         
Pro Pro Arg Gly Ile His Phe Thr Val Glu Glu Gly Asp Leu Gly Phe
515                 520                 525             
Thr Leu Arg Gly Asn Thr Pro Val Gln Val His Phe Leu Asp Pro His
530                 535                 540                 
Cys Ser Ala Ser Leu Ala Gly Ala Lys Glu Gly Asp Tyr Ile Val Ser
545                 550                 555                 560 
Ile Gln Gly Val Asp Cys Lys Trp Leu Thr Val Ser Glu Val Met Lys
565                 570                 575     
Leu Leu Lys Ser Phe Gly Gly Glu Glu Val Glu Met Lys Val Val Ser
580                 585                 590         
Leu Leu Asp Ser Thr Ser Ser Met His Asn Lys Cys Ala Thr Tyr Ser
595                 600                 605             
Val Gly Met Gln Lys Thr Tyr Ser Met Ile Cys Leu Ser Met Asp Asp
610                 615                 620                 
Asp Asp Lys Ala Asp Lys Thr Lys Lys Ile Ser Lys Lys Leu Ser Phe
625                 630                 635                 640 
Leu Ser Trp Gly Thr Ser Lys Asn Arg Gln Lys Ser Ala Ser Thr Leu
645                 650                 655     
Cys Leu Pro Glu Val Gly Leu Ala Arg Ser Gln Asn Lys Lys Lys Leu
660                 665                 670         
Pro Thr Pro Phe Ser Leu Leu Asn Ser Asp Ser Ser Leu Tyr
675                 680                 685