【手続補正書】
【提出日】平成17年7月27日(2005.7.27)
【手続補正１】
【補正対象書類名】明細書
【補正対象項目名】００８２
【補正方法】変更
【補正の内容】
【００８２】
【配列表】
SEQUENCE LISTING
<110>  MIYATA, TOSHIYUKI
<120>  A Method for testing of thrombophilic diathesis
<130>  NCV-A0201
<140> JP 2002-111241
<141> 2002-04-12
<160> 6 
<170>  PatentIn version 2.1
<210>  1
<211>  4933
<212>  DNA
<213>  Homo sapiens
<400>  1
aaccacgatg tctttggcac agcctctcat ctgtcagatg ggagcgggga ccccggagag     60
ggagtcagcc gaggtcctgg cattccttgt gaacccccgt ctgtgggttt ctggtccagt    120
gtcccttctc cagattagat ggcttaggcc tcctctaagg gggtgggcgt gcacatccgg    180
agagctgtct ggtgtgcagg actgggctgc aggttaccct gaactgcaac catcttagag    240
caaggcccag cttgcagcag gaggagctgc aggccgccca ccctagccac ggcccctgcc    300
ctggcaggaa gcttccaaga gtaaacactg cctaatcgtc ccgcccagta gtgagcaggc    360
ctgtcccatt ccatactgac cagattccca gtcaccaagg ccccctctca ctccgctcca    420
ctcctcgggc tggctctcct gaggatgcac cagcgtcacc cccgggcaag atgccctccc    480
ctctgtgtgg ccggaatcct tgcctgtggc tttctcctgg gctgctgggg accctcccat    540
ttccagcaga gttgtcttca ggctttggag ccacaggccg tgtcttctta cttgagccct    600
ggtgctccct taaaaggccg ccctccttcc cctggcttcc agaggcagag gcagaggcag    660
aggcgggctg caggcggcat cctacacctg gagctgctgg tggccgtggg ccccgatgtc    720
ttccaggctc accaggagga cacagagcgc tatgtgctca ccaacctcaa catcggggca    780
gaactgcttc gggacccgtc cctgggggct cagtttcggg tgcacctggt gaagatggtc    840
attctgacag agcctgaggg tgctccaaat atcacagcca acctcacctc gtccctgctg    900
agcgtctgtg ggtggagcca gaccatcaac cctgaggacg acacggatcc tggccatgct    960
gacctggtcc tctatatcac taggtttgac ctggagttgc ctgatggtaa ccggcaggtg   1020
cggggcgtca cccagctggg cggtgcctgc tccccaacct ggagctgcct cattaccgag   1080
gacactggct tcgacctggg agtcaccatt gcccatgaga ttgggcacag cttcggcctg   1140
gagcacgacg gcgcgcccgg cagcggctgc ggccccagcg gacacgtgat ggcttcggac   1200
ggcgccgcgc cccgcgccgg cctcgcctgg tccccctgca gccgccggca gctgctgagc   1260
ctgctcagcg caggacgggc gcgctgcgtg tgggacccgc cgcggcctca acccgggtcc   1320
gcggggcacc cgccggatgc gcagcctggc ctctactaca gcgccaacga gcagtgccgc   1380
gtggccttcg gccccaaggc tgtcgcctgc accttcgcca gggagcacct ggatatgtgc   1440
caggccctct cctgccacac agacccgctg gaccaaagca gctgcagccg cctcctcgtt   1500
cctctcctgg atgggacaga atgtggcgtg gagaagtggt gctccaaggg tcgctgccgc   1560
tccctggtgg agctgacccc catagcagca gtgcatgggc gctggtctag ctggggtccc   1620
cgaagtcctt gctcccgctc ctgcggagga ggtgtggtca ccaggaggcg gcagtgcaac   1680
aaccccagac ctgcctttgg ggggcgtgca tgtgttggtg ctgacctcca ggccgagatg   1740
tgcaacactc aggcctgcga gaagacccag ctggagttca tgtcgcaaca gtgcgccagg   1800
accgacggcc agccgctgcg ctcctcccct ggcggcgcct ccttctacca ctggggtgct   1860
gctgtaccac acagccaagg ggatgctctg tgcagacaca tgtgccgggc cattggcgag   1920
agcttcatca tgaagcgtgg agacagcttc ctcgatggga cccggtgtat gccaagtggc   1980
ccccgggagg acgggaccct gagcctgtgt gtgtcgggca gctgcaggac atttggctgt   2040
gatggtagga tggactccca gcaggtatgg gacaggtgcc aggtgtgtgg tggggacaac   2100
agcacgtgca gcccacggaa gggctctttc acagctggca gagcgagaga atatgtcacg   2160
tttctgacag ttacccccaa cctgaccagt gtctacattg ccaaccacag gcctctcttc   2220
acacacttgg cggtgaggat cggagggcgc tatgtcgtgg ctgggaagat gagcatctcc   2280
cctaacacca cctacccctc cctcctggag gatggtcgtg tcgagtacag agtggccctc   2340
accgaggacc ggctgccccg cctggaggag atccgcatct ggggacccct ccaggaagat   2400
gctgacatcc aggtttacag gcggtatggc gaggagtatg gcaacctcac ccgcccagac   2460
atcaccttca cctacttcca gcctaagcca cggcaggcct gggtgtgggc cgctgtgcgt   2520
gggccctgct cggtgagctg tggggcaggg ctgcgctggg taaactacag ctgcctggac   2580
caggccagga aggagttggt ggagactgtc cagtgccaag ggagccagca gccaccagcg   2640
tggccagagg cctgcgtgct cgaaccctgc cctccctact gggcggtggg agacttcggc   2700
ccatgcagcg cctcctgtgg gggcggcctg cgggagcggc cagtgcgctg cgtggaggcc   2760
cagggcagcc tcctgaagac attgccccca gcccggtgca gagcaggggc ccagcagcca   2820
gctgtggcgc tggaaacctg caacccccag ccctgccctg ccaggtggga ggtgtcagag   2880
cccagctcat gcacatcagc tggtggagca ggcctggcct tggagaacga gacctgtgtg   2940
ccaggggcag atggcctgga ggctccagtg actgaggggc ctggctccgt agatgagaag   3000
ctgcctgccc ctgagccctg tgtcgggatg tcatgtcctc caggctgggg ccatctggat   3060
gccacctctg caggggagaa ggctccctcc ccatggggca gcatcaggac gggggctcaa   3120
gctgcacacg tgtggacccc tgcggcaggg tcgtgctccg tctcctgcgg gcgaggtctg   3180
atggagctgc gtttcctgtg catggactct gccctcaggg tgcctgtcca ggaagagctg   3240
tgtggcctgg caagcaagcc tgggagccgg cgggaggtct gccaggctgt cccgtgccct   3300
gctcggtggc agtacaagct ggcggcctgc agcgtgagct gtgggagagg ggtcgtgcgg   3360
aggatcctgt attgtgcccg ggcccatggg gaggacgatg gtgaggagat cctgttggac   3420
acccagtgcc aggggctgcc tcgcccggaa ccccaggagg cctgcagcct ggagccctgc   3480
ccacctaggt ggaaagtcat gtcccttggc ccatgttcgg ccagctgtgg ccttggcact   3540
gctagacgct cggtggcctg tgtgcagctc gaccaaggcc aggacgtgga ggtggacgag   3600
gcggcctgtg cggcgctggt gcggcccgag gccagtgtcc cctgtctcat tgccgactgc   3660
acctaccgct ggcatgttgg cacctggatg gagtgctctg tttcctgtgg ggatggcatc   3720
cagcgccggc gtgacacctg cctcggaccc caggcccagg cgcctgtgcc agctgatttc   3780
tgccagcact tgcccaagcc ggtgactgtg cgtggctgct gggctgggcc ctgtgtggga   3840
cagggtacgc ccagcctggt gccccacgaa gaagccgctg ctccaggacg gaccacagcc   3900
acccctgctg gtgcctccct ggagtggtcc caggcccggg gcctgctctt ctccccggct   3960
ccccagcctc ggcggctcct gcccgggccc caggaaaact cagtgcagtc cagtgcctgt   4020
ggcaggcagc accttgagcc aacaggaacc attgacatgc gaggcccagg gcaggcagac   4080
tgtgcagtgg ccattgggcg gcccctcggg gaggtggtga ccctccgcgt ccttgagagt   4140
tctctcaact gcagtgcggg ggacatgttg ctgctttggg gccggctcac ctggaggaag   4200
atgtgcagga agctgttgga catgactttc agctccaaga ccaacacgct ggtggtgagg   4260
cagcgctgcg ggcggccagg aggtggggtg ctgctgcggt atgggagcca gcttgctcct   4320
gaaaccttct acagagaatg tgacatgcag ctctttgggc cctggggtga aatcgtgagc   4380
ccctcgctga gtccagccac gagtaatgca gggggctgcc ggctcttcat taatgtggct   4440
ccgcacgcac ggattgccat ccatgccctg gccaccaaca tgggcgctgg gaccgaggga   4500
gccaatgcca gctacatctt gatccgggac acccacagct tgaggaccac agcgttccat   4560
gggcagcagg tgctctactg ggagtcagag agcagccagg ctgagatgga gttcagcgag   4620
ggcttcctga aggctcaggc cagcctgcgg ggccagtact ggaccctcca atcatgggta   4680
ccggagatgc aggaccctca gtcctggaag ggaaaggaag gaacctgagg gtcattgaac   4740
atttgttccg tgtctggcca gccctggagg gttgacccct ggtctcagtg ctttccaatt   4800
cgaacttttt ccaatcttag gtatctactt tagagtcttc tccaatgtcc aaaaggctag   4860
ggggttggag gtggggactc tggaaaagca gcccccattt cctcgggtac caataaataa   4920
aacatgcagg ctg                                                      4933
<210>  2
<211>  1427
<212>  PRT
<213>  Homo sapiens
<400>  2
Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      
Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
20                  25                  30          
Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
35                  40                  45              
Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
50                  55                  60                  
Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  
His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
85                  90                  95      
Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
100                 105                 110         
Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
115                 120                 125             
Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
130                 135                 140                 
Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 
Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
165                 170                 175     
Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
180                 185                 190         
Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
195                 200                 205             
Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
210                 215                 220                 
Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 
Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
245                 250                 255     
Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
260                 265                 270         
Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
275                 280                 285             
Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
290                 295                 300                 
Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 
Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
325                 330                 335     
Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
340                 345                 350         
Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
355                 360                 365             
Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
370                 375                 380                 
Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 
Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
405                 410                 415     
Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
420                 425                 430         
Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
435                 440                 445             
Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
450                 455                 460                 
Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 
Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
485                 490                 495     
Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
500                 505                 510         
Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
515                 520                 525             
Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
530                 535                 540                 
Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 
Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
565                 570                 575     
Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
580                 585                 590         
Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
595                 600                 605             
Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
610                 615                 620                 
Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 
Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
645                 650                 655     
Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
660                 665                 670         
Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
675                 680                 685             
Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
690                 695                 700                 
Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 
Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
725                 730                 735     
Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
740                 745                 750         
Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
755                 760                 765             
Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
770                 775                 780                 
Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 
Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
805                 810                 815     
Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
820                 825                 830         
Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
835                 840                 845             
Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
850                 855                 860                 
Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 
Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
885                 890                 895     
Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
900                 905                 910         
Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
915                 920                 925             
Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
930                 935                 940                 
Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 
Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
965                 970                 975     
Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
980                 985                 990         
Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
995                 1000                 1005             
Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
1010                 1015                 1020             
Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
1025                 1030                 1035             
Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
1040                 1045                 1050             
Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
1055                 1060                 1065             
Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
1070                 1075                 1080             
Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
1085                 1090                 1095             
Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
1100                 1105                 1110             
Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
1115                 1120                 1125             
Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
1130                 1135                 1140             
Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
1145                 1150                 1155             
Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
1160                 1165                 1170             
Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
1175                 1180                 1185             
Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
1190                 1195                 1200             
Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
1205                 1210                 1215             
Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
1220                 1225                 1230             
Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
1235                 1240                 1245             
Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
1250                 1255                 1260             
Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
1265                 1270                 1275             
Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
1280                 1285                 1290             
Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
1295                 1300                 1305             
Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
1310                 1315                 1320             
Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
1325                 1330                 1335             
Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
1340                 1345                 1350             
Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
1355                 1360                 1365             
Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
1370                 1375                 1380             
Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
1385                 1390                 1395             
Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
1400                 1405                 1410             
Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr 
1415                 1420                 1425         
<210>  3
<211>  4933
<212>  DNA
<213>  Homo sapiens
<220>
<221>  CDS
<222>  (445)..(4728)
<400>  3
aaccacgatg tctttggcac agcctctcat ctgtcagatg ggagcgggga ccccggagag     60
ggagtcagcc gaggtcctgg cattccttgt gaacccccgt ctgtgggttt ctggtccagt    120
gtcccttctc cagattagat ggcttaggcc tcctctaagg gggtgggcgt gcacatccgg    180
agagctgtct ggtgtgcagg actgggctgc aggttaccct gaactgcaac catcttagag    240
caaggcccag cttgcagcag gaggagctgc aggccgccca ccctagccac ggcccctgcc    300
ctggcaggaa gcttccaaga gtaaacactg cctaatcgtc ccgcccagta gtgagcaggc    360
ctgtcccatt ccatactgac cagattccca gtcaccaagg ccccctctca ctccgctcca    420
ctcctcgggc tggctctcct gagg atg cac cag cgt cac ccc cgg gca aga       471
Met His Gln Arg His Pro Arg Ala Arg          
1               5                            
tgc cct ccc ctc tgt gtg gcc gga atc ctt gcc tgt ggc ttt ctc ctg      519
Cys Pro Pro Leu Cys Val Ala Gly Ile Leu Ala Cys Gly Phe Leu Leu         
10                  15                  20                  25          
ggc tgc tgg gga ccc tcc cat ttc cag cag agt tgt ctt cag gct ttg      567
Gly Cys Trp Gly Pro Ser His Phe Gln Gln Ser Cys Leu Gln Ala Leu         
30                  35                  40              
gag cca cag gcc gtg tct tct tac ttg agc cct ggt gct ccc tta aaa      615
Glu Pro Gln Ala Val Ser Ser Tyr Leu Ser Pro Gly Ala Pro Leu Lys         
45                  50                  55                  
ggc cgc cct cct tcc cct ggc ttc cag agg cag agg cag agg cag agg      663
Gly Arg Pro Pro Ser Pro Gly Phe Gln Arg Gln Arg Gln Arg Gln Arg         
60                  65                  70                      
cgg gct gca ggc ggc atc cta cac ctg gag ctg ctg gtg gcc gtg ggc      711
Arg Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly         
75                  80                  85                          
ccc gat gtc ttc cag gct cac cag gag gac aca gag cgc tat gtg ctc      759
Pro Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu         
90                  95                  100                 105         
acc aac ctc aac atc ggg gca gaa ctg ctt cgg gac ccg tcc ctg ggg      807
Thr Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly         
110                 115                 120             
gct cag ttt cgg gtg cac ctg gtg aag atg gtc att ctg aca gag cct      855
Ala Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro         
125                 130                 135                 
gag ggt gct cca aat atc aca gcc aac ctc acc tcg tcc ctg ctg agc      903
Glu Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser         
140                 145                 150                     
gtc tgt ggg tgg agc cag acc atc aac cct gag gac gac acg gat cct      951
Val Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro         
155                 160                 165                         
ggc cat gct gac ctg gtc ctc tat atc act agg ttt gac ctg gag ttg      999
Gly His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu         
170                 175                 180                 185         
cct gat ggt aac cgg cag gtg cgg ggc gtc acc cag ctg ggc ggt gcc     1047
Pro Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala         
190                 195                 200             
tgc tcc cca acc tgg agc tgc ctc att acc gag gac act ggc ttc gac     1095
Cys Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp         
205                 210                 215                 
ctg gga gtc acc att gcc cat gag att ggg cac agc ttc ggc ctg gag     1143
Leu Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu         
220                 225                 230                     
cac gac ggc gcg ccc ggc agc ggc tgc ggc ccc agc gga cac gtg atg     1191
His Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met         
235                 240                 245                         
gct tcg gac ggc gcc gcg ccc cgc gcc ggc ctc gcc tgg tcc ccc tgc     1239
Ala Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys         
250                 255                 260                 265         
agc cgc cgg cag ctg ctg agc ctg ctc agc gca gga cgg gcg cgc tgc     1287
Ser Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys         
270                 275                 280             
gtg tgg gac ccg ccg cgg cct caa ccc ggg tcc gcg ggg cac ccg ccg     1335
Val Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro         
285                 290                 295                 
gat gcg cag cct ggc ctc tac tac agc gcc aac gag cag tgc cgc gtg     1383
Asp Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val         
300                 305                 310                     
gcc ttc ggc ccc aag gct gtc gcc tgc acc ttc gcc agg gag cac ctg     1431
Ala Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu         
315                 320                 325                         
gat atg tgc cag gcc ctc tcc tgc cac aca gac ccg ctg gac caa agc     1479
Asp Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser         
330                 335                 340                 345         
agc tgc agc cgc ctc ctc gtt cct ctc ctg gat ggg aca gaa tgt ggc     1527
Ser Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly         
350                 355                 360             
gtg gag aag tgg tgc tcc aag ggt cgc tgc cgc tcc ctg gtg gag ctg     1575
Val Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu         
365                 370                 375                 
acc ccc ata gca gca gtg cat ggg cgc tgg tct agc tgg ggt ccc cga     1623
Thr Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg         
380                 385                 390                     
agt cct tgc tcc cgc tcc tgc gga gga ggt gtg gtc acc agg agg cgg     1671
Ser Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg         
395                 400                 405                         
cag tgc aac aac ccc aga cct gcc ttt ggg ggg cgt gca tgt gtt ggt     1719
Gln Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly         
410                 415                 420                 425         
gct gac ctc cag gcc gag atg tgc aac act cag gcc tgc gag aag acc     1767
Ala Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr         
430                 435                 440             
cag ctg gag ttc atg tcg caa cag tgc gcc agg acc gac ggc cag ccg     1815
Gln Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro         
445                 450                 455                 
ctg cgc tcc tcc cct ggc ggc gcc tcc ttc tac cac tgg ggt gct gct     1863
Leu Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala         
460                 465                 470                     
gta tca cac agc caa ggg gat gct ctg tgc aga cac atg tgc cgg gcc     1911
Val Ser His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala         
475                 480                 485                         
att ggc gag agc ttc atc atg aag cgt gga gac agc ttc ctc gat ggg     1959
Ile Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly         
490                 495                 500                 505         
acc cgg tgt atg cca agt ggc ccc cgg gag gac ggg acc ctg agc ctg     2007
Thr Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu         
510                 515                 520             
tgt gtg tcg ggc agc tgc agg aca ttt ggc tgt gat ggt agg atg gac     2055
Cys Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp         
525                 530                 535                 
tcc cag cag gta tgg gac agg tgc cag gtg tgt ggt ggg gac aac agc     2103
Ser Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser         
540                 545                 550                     
acg tgc agc cca cgg aag ggc tct ttc aca gct ggc aga gcg aga gaa     2151
Thr Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu         
555                 560                 565                         
tat gtc acg ttt ctg aca gtt acc ccc aac ctg acc agt gtc tac att     2199
Tyr Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile         
570                 575                 580                 585         
gcc aac cac agg cct ctc ttc aca cac ttg gcg gtg agg atc gga ggg     2247
Ala Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly         
590                 595                 600             
cgc tat gtc gtg gct ggg aag atg agc atc tcc cct aac acc acc tac     2295
Arg Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr         
605                 610                 615                 
ccc tcc ctc ctg gag gat ggt cgt gtc gag tac aga gtg gcc ctc acc     2343
Pro Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr         
620                 625                 630                     
gag gac cgg ctg ccc cgc ctg gag gag atc cgc atc tgg gga ccc ctc     2391
Glu Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu         
635                 640                 645                         
cag gaa gat gct gac atc cag gtt tac agg cgg tat ggc gag gag tat     2439
Gln Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr         
650                 655                 660                 665         
ggc aac ctc acc cgc cca gac atc acc ttc acc tac ttc cag cct aag     2487
Gly Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys         
670                 675                 680             
cca cgg cag gcc tgg gtg tgg gcc gct gtg cgt ggg ccc tgc tcg gtg     2535
Pro Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val         
685                 690                 695                 
agc tgt ggg gca ggg ctg cgc tgg gta aac tac agc tgc ctg gac cag     2583
Ser Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln         
700                 705                 710                     
gcc agg aag gag ttg gtg gag act gtc cag tgc caa ggg agc cag cag     2631
Ala Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln         
715                 720                 725                         
cca cca gcg tgg cca gag gcc tgc gtg ctc gaa ccc tgc cct ccc tac     2679
Pro Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr         
730                 735                 740                 745         
tgg gcg gtg gga gac ttc ggc cca tgc agc gcc tcc tgt ggg ggc ggc     2727
Trp Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly         
750                 755                 760             
ctg cgg gag cgg cca gtg cgc tgc gtg gag gcc cag ggc agc ctc ctg     2775
Leu Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu         
765                 770                 775                 
aag aca ttg ccc cca gcc cgg tgc aga gca ggg gcc cag cag cca gct     2823
Lys Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala         
780                 785                 790                     
gtg gcg ctg gaa acc tgc aac ccc cag ccc tgc cct gcc agg tgg gag     2871
Val Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu         
795                 800                 805                         
gtg tca gag ccc agc tca tgc aca tca gct ggt gga gca ggc ctg gcc     2919
Val Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala         
810                 815                 820                 825         
ttg gag aac gag acc tgt gtg cca ggg gca gat ggc ctg gag gct cca     2967
Leu Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro         
830                 835                 840             
gtg act gag ggg cct ggc tcc gta gat gag aag ctg cct gcc cct gag     3015
Val Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu         
845                 850                 855                 
ccc tgt gtc ggg atg tca tgt cct cca ggc tgg ggc cat ctg gat gcc     3063
Pro Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala         
860                 865                 870                     
acc tct gca ggg gag aag gct ccc tcc cca tgg ggc agc atc agg acg     3111
Thr Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr         
875                 880                 885                         
ggg gct caa gct gca cac gtg tgg acc cct gcg gca ggg tcg tgc tcc     3159
Gly Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser         
890                 895                 900                 905         
gtc tcc tgc ggg cga ggt ctg atg gag ctg cgt ttc ctg tgc atg gac     3207
Val Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp         
910                 915                 920             
tct gcc ctc agg gtg cct gtc cag gaa gag ctg tgt ggc ctg gca agc     3255
Ser Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser         
925                 930                 935                 
aag cct ggg agc cgg cgg gag gtc tgc cag gct gtc ccg tgc cct gct     3303
Lys Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala         
940                 945                 950                     
cgg tgg cag tac aag ctg gcg gcc tgc agc gtg agc tgt ggg aga ggg     3351
Arg Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly         
955                 960                 965                         
gtc gtg cgg agg atc ctg tat tgt gcc cgg gcc cat ggg gag gac gat     3399
Val Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp         
970                 975                 980                 985         
ggt gag gag atc ctg ttg gac acc cag tgc cag ggg ctg cct cgc  ccg    3447
Gly Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg  Pro        
990                 995                 1000            
gaa ccc cag gag  gcc tgc agc ctg gag  ccc tgc cca cct agg  tgg      3492
Glu Pro Gln Glu  Ala Cys Ser Leu Glu  Pro Cys Pro Pro Arg  Trp          
1005                 1010                 1015              
aaa gtc atg tcc  ctt ggc cca tgt tcg  gcc agc tgt ggc ctt  ggc      3537
Lys Val Met Ser  Leu Gly Pro Cys Ser  Ala Ser Cys Gly Leu  Gly          
1020                 1025                 1030              
act gct aga cgc  tcg gtg gcc tgt gtg  cag ctc gac caa ggc  cag      3582
Thr Ala Arg Arg  Ser Val Ala Cys Val  Gln Leu Asp Gln Gly  Gln          
1035                 1040                 1045              
gac gtg gag gtg  gac gag gcg gcc tgt  gcg gcg ctg gtg cgg  ccc      3627
Asp Val Glu Val  Asp Glu Ala Ala Cys  Ala Ala Leu Val Arg  Pro          
1050                 1055                 1060              
gag gcc agt gtc  ccc tgt ctc att gcc  gac tgc acc tac cgc  tgg      3672
Glu Ala Ser Val  Pro Cys Leu Ile Ala  Asp Cys Thr Tyr Arg  Trp          
1065                 1070                 1075              
cat gtt ggc acc  tgg atg gag tgc tct  gtt tcc tgt ggg gat  ggc      3717
His Val Gly Thr  Trp Met Glu Cys Ser  Val Ser Cys Gly Asp  Gly          
1080                 1085                 1090              
atc cag cgc cgg  cgt gac acc tgc ctc  gga ccc cag gcc cag  gcg      3762
Ile Gln Arg Arg  Arg Asp Thr Cys Leu  Gly Pro Gln Ala Gln  Ala          
1095                 1100                 1105              
cct gtg cca gct  gat ttc tgc cag cac  ttg ccc aag ccg gtg  act      3807
Pro Val Pro Ala  Asp Phe Cys Gln His  Leu Pro Lys Pro Val  Thr          
1110                 1115                 1120              
gtg cgt ggc tgc  tgg gct ggg ccc tgt  gtg gga cag ggt acg  ccc      3852
Val Arg Gly Cys  Trp Ala Gly Pro Cys  Val Gly Gln Gly Thr  Pro          
1125                 1130                 1135              
agc ctg gtg ccc  cac gaa gaa gcc gct  gct cca gga cgg acc  aca      3897
Ser Leu Val Pro  His Glu Glu Ala Ala  Ala Pro Gly Arg Thr  Thr          
1140                 1145                 1150              
gcc acc cct gct  ggt gcc tcc ctg gag  tgg tcc cag gcc cgg  ggc      3942
Ala Thr Pro Ala  Gly Ala Ser Leu Glu  Trp Ser Gln Ala Arg  Gly          
1155                 1160                 1165              
ctg ctc ttc tcc  ccg gct ccc cag cct  cgg cgg ctc ctg ccc  ggg      3987
Leu Leu Phe Ser  Pro Ala Pro Gln Pro  Arg Arg Leu Leu Pro  Gly          
1170                 1175                 1180              
ccc cag gaa aac  tca gtg cag tcc agt  gcc tgt ggc agg cag  cac      4032
Pro Gln Glu Asn  Ser Val Gln Ser Ser  Ala Cys Gly Arg Gln  His          
1185                 1190                 1195              
ctt gag cca aca  gga acc att gac atg  cga ggc cca ggg cag  gca      4077
Leu Glu Pro Thr  Gly Thr Ile Asp Met  Arg Gly Pro Gly Gln  Ala          
1200                 1205                 1210              
gac tgt gca gtg  gcc att ggg cgg ccc  ctc ggg gag gtg gtg  acc      4122
Asp Cys Ala Val  Ala Ile Gly Arg Pro  Leu Gly Glu Val Val  Thr          
1215                 1220                 1225              
ctc cgc gtc ctt  gag agt tct ctc aac  tgc agt gcg ggg gac  atg      4167
Leu Arg Val Leu  Glu Ser Ser Leu Asn  Cys Ser Ala Gly Asp  Met          
1230                 1235                 1240              
ttg ctg ctt tgg  ggc cgg ctc acc tgg  agg aag atg tgc agg  aag      4212
Leu Leu Leu Trp  Gly Arg Leu Thr Trp  Arg Lys Met Cys Arg  Lys          
1245                 1250                 1255              
ctg ttg gac atg  act ttc agc tcc aag  acc aac acg ctg gtg  gtg      4257
Leu Leu Asp Met  Thr Phe Ser Ser Lys  Thr Asn Thr Leu Val  Val          
1260                 1265                 1270              
agg cag cgc tgc  ggg cgg cca gga ggt  ggg gtg ctg ctg cgg  tat      4302
Arg Gln Arg Cys  Gly Arg Pro Gly Gly  Gly Val Leu Leu Arg  Tyr          
1275                 1280                 1285              
ggg agc cag ctt  gct cct gaa acc ttc  tac aga gaa tgt gac  atg      4347
Gly Ser Gln Leu  Ala Pro Glu Thr Phe  Tyr Arg Glu Cys Asp  Met          
1290                 1295                 1300              
cag ctc ttt ggg  ccc tgg ggt gaa atc  gtg agc ccc tcg ctg  agt      4392
Gln Leu Phe Gly  Pro Trp Gly Glu Ile  Val Ser Pro Ser Leu  Ser          
1305                 1310                 1315              
cca gcc acg agt  aat gca ggg ggc tgc  cgg ctc ttc att aat  gtg      4437
Pro Ala Thr Ser  Asn Ala Gly Gly Cys  Arg Leu Phe Ile Asn  Val          
1320                 1325                 1330              
gct ccg cac gca  cgg att gcc atc cat  gcc ctg gcc acc aac  atg      4482
Ala Pro His Ala  Arg Ile Ala Ile His  Ala Leu Ala Thr Asn  Met          
1335                 1340                 1345              
ggc gct ggg acc  gag gga gcc aat gcc  agc tac atc ttg atc  cgg      4527
Gly Ala Gly Thr  Glu Gly Ala Asn Ala  Ser Tyr Ile Leu Ile  Arg          
1350                 1355                 1360              
gac acc cac agc  ttg agg acc aca gcg  ttc cat ggg cag cag  gtg      4572
Asp Thr His Ser  Leu Arg Thr Thr Ala  Phe His Gly Gln Gln  Val          
1365                 1370                 1375              
ctc tac tgg gag  tca gag agc agc cag  gct gag atg gag ttc  agc      4617
Leu Tyr Trp Glu  Ser Glu Ser Ser Gln  Ala Glu Met Glu Phe  Ser          
1380                 1385                 1390              
gag ggc ttc ctg  aag gct cag gcc agc  ctg cgg ggc cag tac  tgg      4662
Glu Gly Phe Leu  Lys Ala Gln Ala Ser  Leu Arg Gly Gln Tyr  Trp          
1395                 1400                 1405              
acc ctc caa tca  tgg gta ccg gag atg  cag gac cct cag tcc  tgg      4707
Thr Leu Gln Ser  Trp Val Pro Glu Met  Gln Asp Pro Gln Ser  Trp          
1410                 1415                 1420              
aag gga aag gaa  gga acc tga gggtcattga acatttgttc cgtgtctggc       4758
Lys Gly Lys Glu  Gly Thr                                                
1425                                                        
cagccctgga gggttgaccc ctggtctcag tgctttccaa ttcgaacttt ttccaatctt   4818
aggtatctac tttagagtct tctccaatgt ccaaaaggct agggggttgg aggtggggac   4878
tctggaaaag cagcccccat ttcctcgggt accaataaat aaaacatgca ggctg        4933
<210>  4
<211>  1427
<212>  PRT
<213>  Homo sapiens
<400>  4
Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      
Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
20                  25                  30          
Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
35                  40                  45              
Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
50                  55                  60                  
Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  
His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
85                  90                  95      
Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
100                 105                 110         
Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
115                 120                 125             
Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
130                 135                 140                 
Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 
Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
165                 170                 175     
Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
180                 185                 190         
Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
195                 200                 205             
Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
210                 215                 220                 
Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 
Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
245                 250                 255     
Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
260                 265                 270         
Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
275                 280                 285             
Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
290                 295                 300                 
Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 
Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
325                 330                 335     
Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
340                 345                 350         
Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
355                 360                 365             
Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
370                 375                 380                 
Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 
Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
405                 410                 415     
Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
420                 425                 430         
Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
435                 440                 445             
Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
450                 455                 460                 
Ala Ser Phe Tyr His Trp Gly Ala Ala Val Ser His Ser Gln Gly Asp 
465                 470                 475                 480 
Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
485                 490                 495     
Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
500                 505                 510         
Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
515                 520                 525             
Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
530                 535                 540                 
Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 
Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
565                 570                 575     
Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
580                 585                 590         
Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
595                 600                 605             
Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
610                 615                 620                 
Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 
Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
645                 650                 655     
Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
660                 665                 670         
Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
675                 680                 685             
Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
690                 695                 700                 
Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 
Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
725                 730                 735     
Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
740                 745                 750         
Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
755                 760                 765             
Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
770                 775                 780                 
Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 
Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
805                 810                 815     
Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
820                 825                 830         
Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
835                 840                 845             
Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
850                 855                 860                 
Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 
Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
885                 890                 895     
Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
900                 905                 910         
Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
915                 920                 925             
Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
930                 935                 940                 
Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 
Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
965                 970                 975     
Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
980                 985                 990         
Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
995                 1000                 1005             
Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
1010                 1015                 1020             
Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
1025                 1030                 1035             
Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
1040                 1045                 1050             
Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
1055                 1060                 1065             
Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
1070                 1075                 1080             
Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
1085                 1090                 1095             
Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
1100                 1105                 1110             
Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
1115                 1120                 1125             
Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
1130                 1135                 1140             
Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
1145                 1150                 1155             
Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
1160                 1165                 1170             
Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
1175                 1180                 1185             
Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
1190                 1195                 1200             
Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
1205                 1210                 1215             
Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
1220                 1225                 1230             
Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
1235                 1240                 1245             
Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
1250                 1255                 1260             
Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
1265                 1270                 1275             
Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
1280                 1285                 1290             
Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
1295                 1300                 1305             
Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
1310                 1315                 1320             
Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
1325                 1330                 1335             
Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
1340                 1345                 1350             
Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
1355                 1360                 1365             
Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
1370                 1375                 1380             
Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
1385                 1390                 1395             
Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
1400                 1405                 1410             
Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr 
1415                 1420                 1425         
<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence:an artificially
synthesized primer sequence
<400> 5
tgaggccaca cccacatctt g                                  21
<210> 6
<211> 21
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence:an artificially
synthesized primer sequence
<400> 6
atgccagagc ctgaaccact t                                  21