【手続補正書】
【提出日】平成17年2月14日(2005.2.14)
【手続補正１】
【補正対象書類名】明細書
【補正対象項目名】０４５３
【補正方法】変更
【補正の内容】
【０４５３】
引用文献
特記しない限り、本明細書において引用された全ての文献（前記及び後記）は、その全体が参照として組み入れられる。
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【配列表】
SEQUENCE LISTING
<110> DIVERSA CORPORATION
<120> SYNTHETIC LIGATION REASSEMBLY IN DIRECTED EVOLUTION
<130> GR-A0105
<140> JP 2001-503702       
<141> 2000-06-14  
<150> US 09/332,835 
<151> 1999-06-14
<160> 31
<170> FastSEQ for Windows Version 4.0
<210> 1
<211> 30
<212> DNA
<213> Artificial Sequence
<220> 
<223> defined sequence kernels
<220> 
<221> misc_feature   
<222> 1, 2, 4, 5, 7, 8, 10, 11, 13, 14, 16, 17, 19, 20, 22, 23,
25, 26, 28, and 29
<223> n = A, T, C or G
<400> 1
nnknnknnkn nknnknnknn knnknnknnk                                  30
<210> 2
<211> 30
<212> DNA
<213> Artificial Sequence
<220> 
<223> defined sequence kernels
<220> 
<221> misc_feature   
<222> 1, 2, 4, 5, 7, 8, 10, 11, 13, 14, 16, 17, 19, 20, 22, 23,
25, 26, 28, and 29
<223> n = A, T, C or G
<400> 2
nnmnnmnnmn nmnnmnnmnn mnnmnnmnnm                                  30
<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence
<220> 
<223> spacer peptide
<400> 3
Gly Gly Gly Gly Ser
1               5  
<210> 4
<211> 15
<212> PRT
<213> Artificial Sequence
<220> 
<223> linker peptide
<400> 4
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
1               5                  10                  15  
<210> 5
<211> 10
<212> DNA
<213> Artificial Sequence
<220> 
<223> ribosome binding site (RBS)
<400> 5
aagggaggag                                                        10
<210> 6
<211> 24
<212> DNA
<213> Artificial Sequence
<220> 
<223> primer
<220> 
<221> misc_feature   
<222> 24
<223> n = A, T, C or G from 10 to 100
<400> 6
ctagaagaga ggagaaaacc atgn                                        24
<210> 7
<211> 22
<212> DNA
<213> Artificial Sequence
<220> 
<223> primer
<220> 
<221> misc_feature   
<222> 22
<223> n = A, T, C or G from 10 to 100
<400> 7
gatcaaaggc gcgcctgcag gn                                          22
<210> 8
<211> 23
<212> DNA
<213> Artificial Sequence
<220> 
<223> primer
<400> 8
ctagaaggga ggagaaaacc atg                                         23
<210> 9
<211> 21
<212> DNA
<213> Artificial Sequence
<220> 
<223> primer
<400> 9
gatcaaaggc gcgcctgcag g                                           21
<210> 10
<211> 43
<212> PRT
<213> Artificial Sequence
<220> 
<223> primer
<220> 
<221> VARIANT        
<222> 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17,
18, 19, 20, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34,
35, 36, 37, 38, 39, 40, 41, 42, and 43
<223> Xaa = Any Amino Acid
<220> 
<221> VARIANT        
<222> 23
<223> Xaa = Gly or Thr
<400> 10
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1               5                  10                  15      
Xaa Xaa Xaa Xaa Asn Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
35                  40              
<210> 11
<211> 39
<212> DNA
<213> Artificial Sequence
<220> 
<223> primer
<400> 11
ctagaaggga ggagaattac atgaagcggc ttttagccc                        39
<210> 12
<211> 27
<212> DNA
<213> Artificial Sequence
<220> 
<223> primer
<400> 12
agctaagggt caaggccgca cccgagg                                     27
<210> 13
<211> 150
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 13
aatggacaag aaacgtgtcc gtgtgtacaa cgcggagatg gcctatgtcg acacgggcca 60
gggtgattcc gttctgtttc ttcacggcaa cccgacgtcg tcgtatctgt ggaggggcgt 120
aatgcctttt gtgacggacg tcgcccgatg                                  150
<210> 14
<211> 149
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 14
atggagaaac accgcgtaga agttctcggt tcggagatgg cctacatcga cgtgggagag 60
ggcgacccga tcgtgttcct ccacggaaat cccacgtcgt cgtacctgtg gcggaacgtg 120
attccccacg ttgccggctt gggacgctg                                   149
<210> 15
<211> 150
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 15
acacgacaag cgctacatcg aggtgctggg taagcgaatg gcctatgtcg agatgggcga 60
gggtgatccc atcattttcc aacacggcaa tccgacctca tcgtacctgt ggcgcaacat 120
catgccccat gtgcaacagc tcggtcgctg                                  150
<210> 16
<211> 150
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 16
cgggcagccg aagtacctag aaatcgccgg gaagcgcatg gcgtatatcg acgaaggcaa 60
gggtgacgcc atcgtctttc agcacggcaa ccccacgtcg tcttacttgt ggcgcaacat 120
catgccgcac ttggaagggc tgggccggct                                  150
<210> 17
<211> 150
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 17
ctacccaaaa tttcggcggt cggtcttcgg ccgcgagatg gcgtacgtgg aagtgggacg 60
gggcgacccc atcgtactct tgcacggcaa ccccacctcg tcgtacctct ggcgcaacgt 120
gttgccgcac ctggcgccgt taggccgctg                                  150
<210> 18
<211> 150
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 18
gcatccgaga aagcggatcg ccgtgctcga ttcggagatg agctacgtcg ataccggcga 60
gggagcgccg atcgtgttcc ttcacggcaa cccgacttcc tcctatcttt ggcgcaacat 120
catcccctat ctcgcggatc acggcagatg                                  150
<210> 19
<211> 146
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 19
atgccagcga ttgagctatt ggattcgttc atgaactacc gcgacacggg cgtcggcgat 60
cttcccgtcg tgttcctgca cggcaacccc acgtcgtctc acgtctggcg caacgtgatc 120
ccgcacgtcg ctggccagca ccggtg                                      146
<210> 20
<211> 150
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 20
cccccattat gtggaagtcc tgggcgagcg tatgcactac gtcgatgttg gaccgcggga 60
tggcacgcct gtgctgttcc tgcacggtaa cccgacctcg tcctacctgt ggcgcaacat 120
catcccgcat gtagcaccga gtcatcggtg                                  150
<210> 21
<211> 35
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 21
aggctttcac ggaaccactc tcattgggct tcctg                            35
<210> 22
<211> 1044
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 22
catgatgcac ggcgatattt catcgagcaa tgacacggtc ggcgttgccg tcgtgaacta 60
caagatgcct cgccttcata ccaaggcgga ggttttagcg aacgccagaa agatcggcga 120
gatgatcgtc ggcatgaaga ccggcctgcc cggaatggat ctggtgatct tcccggaata 180
ttcgacccac ggcatcatgt aggactccaa ggaaatgtac gataccgcgt ccgtcgtgcc 240
cggcgaggag accgagattt ttgccgaagc ctgccgcaag gcgaaagtct ggggcgtgtt 300
ctcgctcacc ggcgaacgtc acgaggaaca tccgaagaag gcgccctaca acacgctgat 360
cctgatgaac gacaagggcg aggtggtcca gaaataccgc aagatcatgc cgtgggttcc 420
gatcgagggc tggtaccccg gcaactgcac ctacgtctcc gacgggccga agggcatgaa 480
ggtttcgctg atcatctgcg atgacggcaa ctatccggaa atctggcgcg actgcgccat 540
gaagggcgcc gagctgatcg tgcgctgcca gggctacatg tatccggcca aggaccagca 600
ggtcatcatg gcgaaggcga tggcgtgggc gaataattgt tacgtcgcgg tttccaatgc 660
cgcgggcttc gatggcgtct attcgtattt cggccactcg gcgatcatcg gcttcgatgg 720
ccgcacgctc ggcgaatgcg gcgaggaaga atacggcatc cagtatgccc agctttcgaa 780
gatgctgatc cgcgacgccc gccgcaccgg acaatcggaa aaccatctct tcaagctggt 840
gcatcgtggc tacaccgggt tgatcaactc cggcgagggc gaccgcggtc tcgcggcctg 900
tccttatgag ttctacaaca aatggatcgc cgatccggaa ggcacccgcg aaatggtcga 960
gtcctttacc cggccgacgg tgggaaccga tgaagcgccc atcgaaggca tcccgaacaa 1020
ggtcgcggtg caccgctgaa agct                                        1044
<210> 23
<211> 1044
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 23
catgcatcac ggcgacattt catcgagcaa tgacacggtc ggcgttgccg tcgtgaacta 60
caagatgccg cggcttcaca ccaaggctga ggtgctggcc aactgccgca agatcgccga 120
catgctggtc ggcatgaaga gcggcctgcc gggaatggat ctggtgatct tcccggaata 180
ttccacccac ggcatcatgt acgactccaa ggagatgtac gacacggcgt cgacggtgcc 240
gggtgaagag accgagattt tcgccgaggc ctgccgcaag gccaaggtct ggggcgtgtt 300
ctcgctgacc ggcgagcgcc acgaggagca tcccaataaa gcgccgtaca acaccctgat 360
cctgatgaac gacaagggtg aagtcgttca gaaatatcgc aagatcatgc cgtgggtgcc 420
gatcgaaggc tggtatcccg gcaactgcac gtacgtctcc gaaggcccga agggcatgaa 480
gatgtcgctg atcatctgcg acgacggcaa ctacccggaa atctggcgtg actgcgcgat 540
gaagggcgcc gaactgatca tccgctgcca gggctacatg tatcccgcca aggatcagca 600
ggtgctgatg gcgaaagcaa tggcctgggc caacaacgtt tatgtcgcgg tcgccaatgc 660
ctcgggcttc gacggcgtct actcgtattt cggccattcg gcgatcatcg gcttcgacgg 720
ccgtaccctc ggcgaatgcg gcgaggagga ttatggcatc cagtatgccg ccatctccaa 780
gtcgctgatc cgcgacgcgc gccgcaccgg ccaatcggaa aaccatctct tcaagctggt 840
gcaccgtggc tacaccggca tgatcaattc cggcgagggc gaccgcggtg tcgcggcttg 900
cccgtatgat ttctattcga aatggatcgc cgatcccgag ggtacacgcg agatggtgga 960
atccttcacg cgtccgacgg tgggtgtgga ggaatgcccg atcgagggca ttccgaacaa 1020
ggccaccacg caccgctgaa agct                                        1044
<210> 24
<211> 1044
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 24
catgagacac ggagatatct ccagcagcaa cgattgcgtg ggcgtggccg tcgtgaacta 60
caagatgccg cggctgcata cccgcgcgga ggtgatggag aacgcccgca agatcgccga 120
catggtcgtg ggcatgaagc gcggcctgcc cggcatggac ctggtcatct tccccgagta 180
ctccacccac ggcatcatgt acgacgccaa ggaaatgtac gaaaccgctt cggccattcc 240
gggcgaagag actgctgtgt tcgccgacgc ctgccgcaag gccaacgtat ggggcgtgtt 300
ttcgctgacg ggcgagcgcc acgaagagca cccgaacaag gcgccgtaca acacgctcat 360
cctgatgaac aacaagggcg agatcgtgca gaagtaccgc aagatcatgc cctgggtgcc 420
gatcgaaggc tggtatccgg gcgattgcac ctatgtgtcg gaaggcccca agggactgaa 480
gatcagcctc atcatctgcg acgacggcaa ttaccccgag atctggcgcg attgcgccat 540
gcgcggcgcc gagctgatcg tgcgttgcca gggatacatg tacccggcca aggaccagca 600
ggtcatggtg tccaaggcca tggcgtggat gaacaacgtc tacgtggcgg tggccaatgc 660
cgcgggcttc gacggcgtgt attcctactt cggccattcg gccatcatcg gcttcgacgg 720
ccgcacgctg ggcgaatgcg gtgaagaaga catgggcgtg cagtacgccg agctctccac 780
cagcctgatc cgcgacgcgc gcaagaacat gcagtcgcag aaccacttgt tcaagctggt 840
gcaccgcggc tacaccggca agatcaattc cggcgaagag gccaccggcg tcgcggcatg 900
cccgtacaac ttctacgcca actggatcaa cgatccggag ggcacgcgca agatggtcga 960
atccttcacc cggtccaccg tgggcacgcc ggagtgcccc atggacggca tccccaacga 1020
ggacgccaag caccgctaga agct                                        1044
<210> 25
<211> 89
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 25
aaggtattgg gccttccgga ccgcttcatc gagcaggtgc tccgcttacg gaggtcgagc 60
ctgttgaccg agagccactg gccggtgag                                   89
<210> 26
<211> 81
<212> DNA
<213> Artificial Sequence
<220> 
<223> synthetic
<400> 26
ataacccgga aggcctggcg aagtagctcg tccacgaggc gaatgcctcc agatcggctc 60
tcggtgaccg gccactcggg c                                           81
<210> 27
<211> 1998
<212> DNA
<213> Rhesus
<400> 27
atcgatttaa actgcccgat tgaggttgtc gctgaacact ttgtgagtct tttcgaaggt 60
agatatgaca ctgctttcca gaagtgccgc tgaagcctgg ggtacatatc tgaagcagcg 120
agatgagcgt cccgaggacg tgatacgctg cgactacggc gtcttcagtt tgcgtaatct 180
cgtgttccaa cgttgtctga ctatgttaca gggtgtttat ctgcgacaat acgatcaacc 240
gtgtttacga gaatatatta aaaagaattc tggtactatc attccgttgc gcaacccctg 300
tagctggttt ctcgtccttc gctctggtat agatattccc caggtagaaa cccgttcgtt 360
cgacgagtat ctttgctgca aagagaaatt ggaagcactg ggaatattgg gggtgcagtt 420
gcgtgatggc agtgatcgca aaaaaatcca ggagactacg tgtgtggttc tgctgggaag 480
ctatggattt gtgtacgtgt atgactggga cagtgacgga ctctttcaga taggtacctc 540
actcaaagaa ctcgcgcacc acggtttact gacatgtgaa tcggtatatc gccatccgca 600
aacgcccttc tccagcaccg agcctcgttt tcaagtcgag aaattgttgt gtctcgatcc 660
gacagacgca cgtggtctag ctaagaccgc agaagagttt catggcgtta acgtagtagt 720
gaaaacccct gggcgatcgg aggccgatcc cttgctcctt ctgggtactg tggagaagct 780
acgtcaaatg tatccctttg ctaaaatgag agctgataac tttagtaatc tcataaagta 840
tattaatcaa cgcatgtgtt gccgatggta cgtacttggt gttactggcc gttacgctaa 900
ttttggaatt ttgctgacct gtggaataat tctgttggac gagtgcggcg tgtgttatgt 960
gctgagaatc gacgaaagcg acgtgtttcg tctagccgat aacatccaaa tgttgttcag 1020
atgcggcttt cttaagctcc gtggcattac gcgatttgac cgcggattgc gtggcgaggc 1080
tcgtctggag agtgagtgct actgctatca cggtgcccgt aagcaagatc tctcttggtg 1140
gtctatggtc aacacagtta ccgccgagca gctctgtggt gcgtacgact ggctcacgcg 1200
cagtaatcgc gctcatgata aaatacgtac cagttgttgt tggggacgta gtgatttgat 1260
gcctaccgga gtattgcaag agaatcagaa ttggtgcttt ccgtggagca gtgtcacggt 1320
tctacaaggg ccccaaagcg gtgcgtggca agaaaatgat gagttaacgg agaaaacgtc 1380
tgatggtact gtgatgtttc gtgtagacag aggtttttct cccagaaccg taaagttcga 1440
gggtgaaagc gatgactaca cagaagagga ggaagatgat gataaccagt cagaagaaac 1500
ccctcagcat cagcctgttg tcattgtttc acatgaaaca aacggcagtg ttgattctta 1560
tgatgatgag agtgagtcat ctctgtcctc agatacccat gatccaccac ccccagacat 1620
tatggccata atccaaaagg aatggcaaaa cgaagagccg gttaccaatg aaagagaatt 1680
gttactgcgg cgtgcacgac gagctaaaca tatgaaaaag tggcattgtt ccctggaaag 1740
ggttagcatt tatgacccct tgaatgctaa tattcagtgc tttgattaaa caatgcattt 1800
gtattcaatt atctaattcc ggtgtaccgt gtcatttctc catgcagtgg tgggaaacag 1860
attacatatt tagacacacg tatcacttgt gaaagctgag tcaacatcat gcaattgtcg 1920
gacgaggtcc gggtcgttcg ttctgtgttt ctgttacgag tttacatttt attatggttc 1980
aaagtcttct atttctaa                                               1998
<210> 28
<211> 1932
<212> DNA
<213> Homo sapiens
<400> 28
gccatggcat ccgtactggg tcccatttcg gggcacgtgc tgaaagccgt gtttagtcgc 60
ggcgacacgc cggtgctgcc gcacgagacg cgactcctgc agacgggtat ccacgtgcgc 120
gtgagccagc cctcgctgat cctggtgtcg cagtacacgc ccgactcgac gccatgccac 180
cgcggcgaca atcagctgca ggtgcagcac acgtacttta cgggcagcga ggtggagaac 240
gtgtcggtca acgtgcacaa ccccacgggc cggagcatct gccccagcca agagcccatg 300
tcgatctatg tgtacgcgct gccgctcaag atgctgaaca tccccagcat caacgtgcac 360
cactacgcgt cgggggccga gcgcaaacac cgacacctgc ccgtagctga cgctgtgatt 420
cacgcgtcgg gcaaccagat gtggcaggcg cgtctcacgg tctcgggact ggcctggacg 480
cgtcagcaga accagtggaa agagcccgac gtctactaca cgtcagcgtt cgtgtttccg 540
accaaggacg tggcactgcg gcacgtggtg tgcgcgcacg agctggtttg ctccatggag 600
aacacgcgcg caaccaagat gcaggtgata ggtgaccagt acgtcaaggt gtacctggag 660
tccttctgcg aggacgtgcc ctccggcaag ctctttatgc acgtcacgct gggctctgac 720
gtggaagagg acctgacgat gacccgcaac ccgcaaccct tcatgcgccc ccacgagcgc 780
aacggcttta cggtgttgtg tcccaaaaat atgataatca aaccgggcaa gatctcgcac 840
atcatgctgg atgtggcttt tacctcacac gagcattttg ggctgctgtg tcccaagagc 900
atcccgggcc tgagcatctc aggtaaccta ttgatgaacg ggcagcagat cttcctggag 960
gtgcaagcga tacgcgagac cgtggaactg cgtcagtacg atcccgtggc tgcgctcttc 1020
tttttcgata tcgacttgct gctgcagcgc gggcctcagt acagcgaaca ccccaccttc 1080
accagccagt atcgcatcca gggcaagctt gagtaccgac acacctggga ccggcacgac 1140
gagggtgccg cccagggcga cgacgacgtc tggaccagcg gatcggactc cgacgaggaa 1200
ctcgtaacca ccgagcgcaa gacgccccgc gttaccggcg gcggcgccat ggggggcgcc 1260
tccacttccg cgggccggaa acgcaaatca gcatcctcgg cgacggcgtg cacggcgggc 1320
gttatgacac gcggccgcct taaggccgag tccaccgtcg cgcccgaaga ggacaccgac 1380
gaggattccg acaacgaaat ccacaatccg gccgtgttca cctggccgcc ctggcaggcc 1440
ggcatcctgg cccgcaacct ggtgcccatg gttgctacgg ttcagggtca gaatctgaag 1500
taccaggagt tcttctggga cgccaacgac atctaccgca tcttcgccga attggaaggc 1560
gtatggcagc ccgctgcgca acccaaacgt cgccgccacc ggcaagacgc cttgcccggg 1620
ccatgcatcg cctcgacgcc caaaaagcac cgaggttgag ccacccgccg cgcacgctta 1680
ggacgactct ataaaaaccc acgtccactc agacacgcga cttttggccg ccacacctgt 1740
cgccgctgct atatttgcga cagttgccgg aacccttccc gacctcccac gaagacccgt 1800
tcacctttgc gcatcccctg accccccccc tcatcccggc ttcgcgatgt ctcaggcatc 1860
gtcctcgccc ggtgagggac cctcgtcgga agcggccgcg atcagcgagg ccgaagccgc 1920
cagcggaagc tt                                                     1932
<210> 29
<211> 538
<212> DNA
<213> Marmota monax
<400> 29
ggcctaactc tctctgaaac gatgaaatac acaagttatt tcttggcttt tcagctctgc 60
atcattttgg gttcttctag ctgttactcc caggacacag ttaataaaga aatagaagat 120
ttaaaaggat attttaatgc aagtaattca aatgtatcag atggcgggtc tctcttcttg 180
gatattttgg ataaatggaa agaggagagt gacaaaaaag taatccagag ccaaattgtc 240
tctttctact tcaaactctt tgaacactta aaagacaaca agatcatcca aaggagcatg 300
gacaccatca agggggatct ttttgctaag ttcttcaaca gcagtaccaa taagctgcag 360
gacttcctaa aggtgtctca agttcaggta aatgacctga agatccagcg taaagcagtg 420
agtgaactca agaaagtgat gaatgatctg ttaccacact ctaccctaag gaagcgaaaa 480
aggagtcagt cttcgattcg gggtcggaga gcatccaaat aacagtcctc atgcctgc   538
<210> 30
<211> 567
<212> DNA
<213> Felis catus
<400> 30
ctactgattt caacttcttt ggcctaactc tccgaaacga tgaattacac aagttttatt 60
ttcgctttcc agctttgcat aattttgtgt tcttctggtt attactgtca ggccatgttt 120
tttaaagaaa tagaagagct aaagggatat tttaatgcaa gtaatccaga tgtagcagat 180
ggtgggtcgc ttttcgtaga cattttgaag aactggaaag aggagagtga taaaacaata 240
attcaaagcc aaattgtctc cttctacctg aaaatgtttg aaaacctgaa agatgatgac 300
cagcgcattc aaaggagcat ggacaccatc aaggaagaca tgcttgataa gttgttaaat 360
accagctcca gtaaacggga tgacttcctc aagctgattc aaatccctgt gaatgatctg 420
caggtccagc gcaaagcaat aaatgaactc ttcaaagtga tgaatgatct ctcaccaaga 480
tctaacctga ggaagcggaa aaggagccag aatctgtttc gaggccgtag agcatcgaaa 540
taatggttgt cctgcctgca atatttg                                     567
<210> 31
<211> 438
<212> DNA
<213> Homo sapiens
<400> 31
tgttactgcc aggacccata tgtaaaagaa gcagaaaacc ttaagaaata ttttaatgca 60
ggtcattcag atgtagcgga taatggaact cttttcttag gcattttgga gaattggaaa 120
gaggagagtg acagaaaaat aatgcagagc caaattgtct ccttttactt caaacttttt 180
agaaacttta aagatgacca gagcatccaa aagagtgtgg agaccatcaa ggaagacatg 240
aatgtcaagt ttttcaatag caacaaaaag aaacgagatg acttcgaaaa gctgactaat 300
tattcggtaa ctgacttgaa tgtccaacgc aaagcaatac atgaactcat ccaagtgatg 360
gctgaactgt cgccagcagc taaaacaggg aagcggaaaa ggagtcagat gctgtttcga 420
ggtcgaagag catcccag                                               438