【手続補正書】
【提出日】平成16年10月15日(2004.10.15)
【手続補正１】
【補正対象書類名】明細書
【補正対象項目名】０１６２
【補正方法】変更
【補正の内容】
【０１６２】
本明細書で言及される全ての刊行物、特許、および特許出願は、参照として本明細書に組み入れられる。
【図面の簡単な説明】
【図１】  ラクダ（濃青）およびラマ（淡青）より得られた抗体の重鎖における可変領域の構造間の比較を2つの配向からそれぞれ示す写真である。
【図２】  ラクダ抗体の重鎖の可変領域（濃青）、ラマ抗体の重鎖における可変領域（淡青）、および10番目のフィブロネクチン3型モジュール（10Fn3）（黄色）の構造間の比較を示す写真である。
【図３】  10番目のフィブロネクチン3型モジュール（10Fn3）を示す写真であり、IgG重鎖における抗原結合ループに対応するループを赤色で強調した。
【図４】  フィブロネクチン3型タンパク質ドメインおよび関連タンパク質ドメイン間の配列の整列化を図示するグラフである。
【図５】  10Fn3ドメイン、ならびにフィブロネクチン、テネイシン、コラーゲン、およびアンジュリンを含む15個の関連タンパク質間の構造の類似性を示す写真である。この写真では、領域は以下のように分類されている：定常領域は濃青、保存領域は淡青、中性領域は白、可変領域は赤、およびRGDインテグリン結合領域（可変）は黄。
【図６】  9番目および10番目のフィブロネクチン3型モジュールの空間充填モデルを2つの異なる配向からそれぞれ示す写真である。2つのモジュールおよびインテグリン結合ループ（RGD）が分類されている。この図では、青が正電荷を帯びた残基を示し、赤が負電荷を帯びた残基を示し、白が無電荷の残基を示している。
【図７】  7〜10番目のフィブロネクチン3型モジュールの空間充填モデルを3つの異なる配向からそれぞれ示す写真である。4つのモジュールが分類されている。この図では、青が正電荷を帯びた残基を示し、赤が負電荷を帯びた残基を示し、白が無電荷の残基を示している。
【図８】  フィブロネクチン3型ドメインを含むRNA-タンパク質融合体の異なる塩条件下における構造を図示する写真である。
【図９】  PCRシグナル解析によって測定されたフィブロネクチン3型ドメインを含むRNA-タンパク質融合体の選択を図示する一連の写真である。
【図１０】  RNA-タンパク質融合体および遊離タンパク質の選択間における比較、ならびに本明細書に記載の選択間において、TNF-αとの結合％での増加を図示するグラフである。
【図１１】  IgG、10Fn3、Fn-CH1-CH2-CH3、およびFn-CH2-CH3を示す一連の概略図である（左上から時計回りに）。
【図１２】  IgG（X線結晶学）および10Fn3（NMRおよびX線結晶学）の既知の三次元構造に基づいたFn-CH1-CH2-CH3の分子モデルを示す写真である。
【図１３】  TNF-α結合物の10Fn3に基づく核酸-タンパク質融合体の例示的な選択の時間経過を示すグラフである。TNF-α-セファロースに結合した、核酸-タンパク質融合体のプール（白抜きのひし形）および遊離のタンパク質のプール（白抜きの丸）の割合、ならびに未誘導化セファロースに結合した遊離タンパク質のプール（黒丸）の割合が示されている。
【図１４および図１５】  TNF-αFn結合物によるTNF-α結合を示すグラフである。特に、これらの図はそれぞれ10Fn3融合体チップおよび非融合体チップから得られた質量スペクトルデータを示す。
【図１６および図１７】  それぞれ10Fn3アレイのリン光画像および蛍光スキャンであり、TNF-α結合を示す。
【図１８】  ラマVHドメインおよび野生型ヒト10Fn3ドメインの一次配列の整列化を示すグラフである。2つの配列の間の相同残基が示されている。選択されたクローンの約45％で変異している無作為化ループの外の10Fn3残基は、野生型10Fn3配列の下の矢印で示されており、選択された残基を示す文字が付けられている。
【図１９】  ラマVHドメインおよび野生型ヒト10Fn3ドメインの模式図である。変異した枠組みの残基が示されている。
【図２０】  元のライブラリー（R0）およびTNF-αを用いた10回の選択後（R10）から翻訳された遊離タンパク質プールの結合効率および特異性を示すグラフである。未誘導化セファロース、TNF-α-セファロース、IL-1α-セファロース、およびIL-13-セファロースに対するタンパク質プールの結合が比較されている。
【図２１】  最大3個のループのディスプレイのための一連のIgG様骨格である。
【図２２】  最大4個、または6個のループのディスプレイのための一連のIgG様骨格である。
【図２３】  ループ構造のディスプレイのための、IgGに関連のない一連の骨格である。
【図２４】  固相表面に固定化された模倣物による標的（TNF-α）の特異的キャプチャを示す写真およびグラフである。
【図２５】  本発明の典型的なTNF-α結合体（配列番号：33〜140）を示すグラフである。
【配列表】
SEQUENCE LISTING
<110> Phylos, Inc.
<120> PROTEIN SCAFFOLDS FOR ANTIBODY MIMICS
AND OTHER BINDING PROTEINS
<130> CE-A0302
<140> JP   2002-536306      
<141> 2001-10-16  
<150> US   09/688,566       
<151> 2000-10-16  
<160> 202
<170> FastSEQ for Windows Version 4.0
<210> 1
<211> 122
<212> DNA
<213> Homo sapiens
<400> 1
ggaattccta atacgactca ctatagggac aattactatt tacaattaca atgcatcacc      60
atcaccatca cgtttctgat gttccgaggg acctggaagt tgttgctgcg acccccacca     120
gc                                                                    122
<210> 2
<211> 104
<212> DNA
<213> Homo sapiens
<400> 2
ggaattccta atacgactca ctatagggac aattactatt tacaattaca atggtttctg      60
atgttccgag ggacctggaa gttgttgctg cgacccccac cagc                      104
<210> 3
<211> 126
<212> DNA
<213> Homo sapiens
<220> 
<221> misc_feature   
<222> (1)...(126)
<223> n = A,T,C or G
<221> misc_feature   
<222> (1)...(126)
<223> s = C or G
<221> misc_feature   
<222> 74, 75, 77, 78, 80, 81, 83, 84, 86, 87, 89, 90, 92, 93
<223> n = A,T,C or G
<400> 3
agcggatgcc ttgtcgtcgt cgtccttgta gtcgctcttc cctgtttctc cgtaagtgat      60
cctgtaatat ctsnnsnnsn nsnnsnnsnn snnccagctg atcagtaggc tggtgggggt     120
cgcagc                                                                126
<210> 4
<211> 62
<212> DNA
<213> Homo sapiens
<400> 4
agcggatgcc ttgtcgtcgt cgtccttgta gtcgctcttc cctgtttctc cgtaagtgat      60
cc                                                                     62
<210> 5
<211> 99
<212> DNA
<213> Homo sapiens
<400> 5
ggaattccta atacgactca ctatagggac aattactatt tacaattaca atgcatcacc      60
atcaccatca cctcttcaca ggaggaaata gccctgtcc                             99
<210> 6
<211> 132
<212> DNA
<213> Homo sapiens
<220> 
<221> misc_feature   
<222> (1)...(132)
<223> n = A,T,C or G
<221> misc_feature   
<222> (1)...(132)
<223> s = C or G
<221> misc_feature   
<222> 83, 84, 86, 87, 89, 90, 92, 93
<223> n = A,T,C or G
<400> 6
agcggatgcc ttgtcgtcgt cgtccttgta gtcgctcttc gtataatcaa ctccaggttt      60
aaggccgctg atggtagctg tsnnsnnsnn snnaggcaca gtgaactcct ggacagggct     120
atttcctcct gt                                                         132
<210> 7
<211> 64
<212> DNA
<213> Homo sapiens
<400> 7
agcggatgcc ttgtcgtcgt cgtccttgta gtcgctcttc gtataatcaa ctccaggttt      60
aagg                                                                   64
<210> 8
<211> 101
<212> DNA
<213> Homo sapiens
<400> 8
ggaattccta atacgactca ctatagggac aattactatt tacaattaca atgcatcacc      60
atcaccatca cctcttctat accatcactg tgtatgctgt c                         101
<210> 9
<211> 114
<212> DNA
<213> Homo sapiens
<220> 
<221> misc_feature   
<222> (1)...(114)
<223> n = A,T,C or G
<221> misc_feature   
<222> (1)...(114)
<223> s = C or G
<221> misc_feature   
<222> 59, 60, 62, 63, 65, 66, 68, 69, 71, 72, 74, 75, 77, 78, 80,
81, 83, 84, 86, 87
<223> n = A,T,C or G
<400> 9
agcggatgcc ttgtcgtcgt cgtccttgta gtctgttcgg taattaatgg aaattggsnn      60
snnsnnsnns nnsnnsnnsn nsnnsnnagt gacagcatac acagtgatgg tata           114
<210> 10
<211> 57
<212> DNA
<213> Homo sapiens
<400> 10
agcggatgcc ttgtcgtcgt cgtccttgta gtctgttcgg taattaatgg aaattgg         57
<210> 11
<211> 45
<212> DNA
<213> T7 phage and tobacco mosaic virus
<400> 11
gcgtaatacg actcactata gggacaatta ctatttacaa ttaca                      45
<210> 12
<211> 33
<212> DNA
<213> Artificial Sequence
<220> 
<223> Flag sequence
<400> 12
agcggatgcc ttgtcgtcgt cgtccttgta gtc                                   33
<210> 13
<211> 19
<212> DNA
<213> Artificial Sequence
<220> 
<223> Splint oligonucleotide
<221> misc_feature   
<222> (1)...(19)
<223> n = A,T,C or G
<221> misc_feature   
<222> 10
<223> n = A,T,C or G
<400> 13
tttttttttn agcggatgc                                                   19
<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence
<220> 
<223> Puromycin linker oligonucleotide
<400> 14
aaaaaaaaaa aaaaaaaacc                                                  20
<210> 15
<211> 30
<212> DNA
<213> Mus musculus
<400> 15
gcggcagggt ttgcttactg gggccaaggg                                       30
<210> 16
<211> 27
<212> DNA
<213> Mus musculus
<400> 16
gggaggggtg gaggtaggtc acagtcc                                          27
<210> 17
<211> 30
<212> DNA
<213> Mus musculus
<400> 17
tttgctagct ttaccaggag agtgggaggc                                       30
<210> 18
<211> 33
<212> DNA
<213> Mus musculus
<400> 18
aaaaagcttg ccaaaacgac acccccatct gtc                                   33
<210> 19
<211> 33
<212> DNA
<213> Mus musculus
<400> 19
catatggttt ctgatattcc gagagatctg gag                                   33
<210> 20
<211> 43
<212> DNA
<213> Mus musculus
<400> 20
catatgcatc accatcacca tcacgtttct gatattccga gag                        43
<210> 21
<211> 30
<212> DNA
<213> Mus musculus
<400> 21
gaattcctat gttttataat tgatggaaac                                       30
<210> 22
<211> 19
<212> DNA
<213> Homo sapiens
<400> 22
tgtaaatagt aattgtccc                                              19
<210> 23
<211> 20
<212> DNA
<213> Homo sapiens
<400> 23
tttttttttt tttttttttt                                             20
<210> 24
<211> 15
<212> DNA
<213> Artificial Sequence
<220> 
<223> Oligonucleotide
<400> 24
cctgtaggtg tccat                                                  15
<210> 25
<211> 16
<212> DNA
<213> Homo sapiens
<400> 25
catcgtcctt gtagtc                                                 16
<210> 26
<211> 13
<212> DNA
<213> Artificial Sequence
<220> 
<223> Oligonucleotide
<400> 26
cgtcgtaggg gta                                                    13
<210> 27
<211> 17
<212> DNA
<213> Artificial Sequence
<220> 
<223> Oligonucleotide
<400> 27
caggtcttct tcagaga                                                17
<210> 28
<211> 24
<212> DNA
<213> Homo sapiens
<400> 28
catatggttt ctgatgttcc gagg                                        24
<210> 29
<211> 32
<212> DNA
<213> Homo sapiens
<400> 29
gaattcctat gttcggtaat taatggaaat tg                               32
<210> 30
<211> 19
<212> DNA
<213> Artificial Sequence
<220> 
<223> DNA splint Oligonucleotide
<221> misc_feature   
<222> 10
<223> n = A,T,C or G
<400> 30
tttttttttn agcggatgc                                              19
<210> 31
<211> 7
<212> PRT
<213> Homo sapien
<400> 31
Asn Arg Ser Gly Leu Gln Ser
1               5          
<210> 32
<211> 10
<212> PRT
<213> Homo sapien
<400> 32
Ala Gln Thr Gly His His Leu His Asp Lys
1               5                  10  
<210> 33
<211> 94
<212> PRT
<213> Homo sapien
<400> 33
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp
65                  70                  75                  80  
Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 34
<211> 95
<212> PRT
<213> Homo sapiens
<400> 34
Val Ser Glu Ile Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Phe Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Leu Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Asn Thr Ile Thr Gly Tyr Ala Val Thr Thr Thr Tyr
65                  70                  75                  80  
Arg Thr Arg Ile Asp Lys Gln Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  95  
<210> 35
<211> 90
<212> PRT
<213> Homo sapien
<400> 35
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Lys Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Glu Leu Asn Pro Thr Ala Thr Ile Ser Arg Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gln Asn Gly Thr
65                  70                  75                  80  
Pro Arg Arg His Leu Arg Pro Asn Phe His
85                  90  
<210> 36
<211> 95
<212> PRT
<213> Homo sapien
<400> 36
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Gly Leu Leu Ile Ser Trp Asn Lys Ser Arg Met Thr Thr Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Val Thr Asp Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Asn Thr Ile Ile Val His Ala Val Thr Leu Thr Asn
65                  70                  75                  80  
Gln Asn Ser Asp His Thr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  95  
<210> 37
<211> 91
<212> PRT
<213> Homo sapien
<400> 37
Val Ser Asp Val Pro Arg Asp Leu Asp Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Asp Ser Ser His Arg Tyr Tyr Arg Ile Thr
20                  25                  30          
Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Ala Pro
35                  40                  45              
Asn Asn Pro Pro Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp
50                  55                  60                  
Tyr Thr Ile Thr Val Tyr Ala Val Thr Pro Asp Gly Ser Arg His Met
65                  70                  75                  80  
Leu Thr Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90      
<210> 38
<211> 88
<212> PRT
<213> Homo sapiens
<400> 38
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp His Asn Asn His Ile Asp Met Arg Tyr Tyr
20                  25                  30          
Arg Ser Ala Asn Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Val Phe
35                  40                  45              
Thr Val Pro Gln Arg Arg Gln Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Pro Lys Asn Gln
65                  70                  75                  80  
Gly Arg Arg Arg Gln Gly Ile Arg
85              
<210> 39
<211> 94
<212> PRT
<213> Homo sapiens
<400> 39
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Ser Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Arg Thr Pro Ala Ser Pro His Gly Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Glu Glu Phe
35                  40                  45              
Thr Val Pro Leu Leu Trp Pro Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Pro Thr His Met
65                  70                  75                  80  
Leu Lys Pro Gln Ser Met Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 40
<211> 94
<212> PRT
<213> Homo sapien
<400> 40
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Arg Thr Pro Ala Ser Pro His Gly Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Glu Glu Phe
35                  40                  45              
Thr Val Pro Leu Leu Trp Pro Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Pro Thr His Met
65                  70                  75                  80  
Leu Lys Pro Gln Ser Met Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 41
<211> 94
<212> PRT
<213> Homo sapien
<400> 41
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Ala Ser Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Arg Pro Asn Pro Arg Leu Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Leu Phe Ser Thr Ala Thr Ile Ser Gly Leu Asn Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Pro Lys Glu Thr
65                  70                  75                  80  
Ser Asn Ile Phe Ile Ala Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 42
<211> 94
<212> PRT
<213> Homo sapien
<400> 42
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Ser Thr
1               5                  10                  15      
Cys Leu Leu Ile Ser Trp Arg Pro Asn Pro Arg Leu Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Leu Phe Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Pro Lys Glu Thr
65                  70                  75                  80  
Ser Asn Ile Phe Ile Ala Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 43
<211> 94
<212> PRT
<213> Homo sapien
<400> 43
Val Ser Asp Val Pro Arg Asp Pro Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Asp Pro Asn Ile Arg Leu Arg Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Phe Phe Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ala Ser Arg Asn
65                  70                  75                  80  
Glu Asp Thr Arg Phe Gly Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 44
<211> 94
<212> PRT
<213> Homo sapiens
<400> 44
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Phe Arg Ser Leu Gln Arg Asp Arg Asp Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Phe Arg Met Lys Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Ile Thr Pro Pro Asp Lys
65                  70                  75                  80  
Met Glu Pro Pro Lys Gly Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 45
<211> 94
<212> PRT
<213> Homo sapiens
<400> 45
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Tyr Arg His Thr Tyr Arg Asp Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Ser
35                  40                  45              
Thr Val Pro Pro Trp Ala Thr Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Ala Val Tyr Ala Val Thr Asp Thr Gly Tyr
65                  70                  75                  80  
Asp Val His Thr Lys Arg Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 46
<211> 94
<212> PRT
<213> Homo sapiens
<400> 46
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Ala Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Tyr Arg His Thr Tyr Arg Asp Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Thr Thr Ala Ala Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Ala Ile Ala Val Tyr Ala Val Thr Asp Thr Gly Tyr
65                  70                  75                  80  
Asp Val His Thr Lys Arg Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 47
<211> 94
<212> PRT
<213> Homo sapiens
<400> 47
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Gln Leu Ile Ser Trp Pro Phe Gly Trp Tyr Pro Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Arg Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Tyr Ser Asp
65                  70                  75                  80  
Phe Ser Gln Val His Thr Pro Asn Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 48
<211> 93
<212> PRT
<213> Homo sapiens
<400> 48
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Pro Gly Arg Thr Tyr Ser Arg Tyr Arg
20                  25                  30          
Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr
35                  40                  45              
Val Pro Pro Trp Ala Asn Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly
50                  55                  60                  
Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Pro Leu Pro Ile Pro
65                  70                  75                  80  
Thr Leu Val His Gly Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90              
<210> 49
<211> 94
<212> PRT
<213> Homo sapiens
<400> 49
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Ala Ser Pro Pro Met Trp Cys Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Gly Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Thr Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Glu Tyr Leu Pro
65                  70                  75                  80  
Glu Trp Asn Met Thr Gln Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 50
<211> 94
<212> PRT
<213> Homo sapiens
<400> 50
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Ala Ser Pro Pro Met Trp Cys Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Thr Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Met Tyr Ala Val Thr Glu Tyr Leu Pro
65                  70                  75                  80  
Glu Trp Asn Met Thr Gln Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 51
<211> 93
<212> PRT
<213> Homo sapiens
<400> 51
Asn Thr Thr His Tyr Arg Lys Asn Asn Tyr Tyr Ala Thr Pro Thr Ser
1               5                  10                  15      
Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr Arg
20                  25                  30          
Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr
35                  40                  45              
Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro Gly
50                  55                  60                  
Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp Thr
65                  70                  75                  80  
Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90              
<210> 52
<211> 93
<212> PRT
<213> Homo sapiens
<400> 52
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ser Ala Thr Arg
65                  70                  75                  80  
Thr Val Lys Arg Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90              
<210> 53
<211> 94
<212> PRT
<213> Homo sapiens
<400> 53
Val Ser Asp Ala Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Met Tyr Ala Val Thr Ser Asn Val Gly
65                  70                  75                  80  
Arg Leu Asp Thr Arg Tyr Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 54
<211> 94
<212> PRT
<213> Homo sapiens
<400> 54
Val Ser Asp Val Pro Arg Asp Leu Asp Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Glu Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ser Asn Val Gly
65                  70                  75                  80  
Arg Leu Asp Thr Arg Tyr Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 55
<211> 94
<212> PRT
<213> Homo sapiens
<400> 55
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Lys Glu Pro Gln
65                  70                  75                  80  
Arg His Ala Leu Val Thr Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 56
<211> 94
<212> PRT
<213> Homo sapiens
<400> 56
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Glu Thr Pro Ser
65                  70                  75                  80  
Thr Lys Pro His Asn Val Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 57
<211> 74
<212> PRT
<213> Homo sapiens
<400> 57
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn His Pro Gly Pro Phe Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Arg Thr Ala Ile Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala
65                  70                  
<210> 58
<211> 93
<212> PRT
<213> Homo sapiens
<400> 58
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Thr Ser
1               5                  10                  15      
Leu Leu Ile Ser Trp Asp Tyr Asn Arg Thr Gly Asp Arg Tyr Tyr Arg
20                  25                  30          
Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr
35                  40                  45              
Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Gly Gly Leu Lys Pro Gly
50                  55                  60                  
Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ala Gln Thr Gly His
65                  70                  75                  80  
His Leu His Asp Lys Pro Ile Ser Ile Asn Tyr Arg Ser
85                  90              
<210> 59
<211> 94
<212> PRT
<213> Homo sapiens
<400> 59
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Ser Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp His Tyr Leu Arg Arg Gln Pro Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Gly Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ala Gln Thr Gly
65                  70                  75                  80  
His His Leu His Asp Glu Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 60
<211> 94
<212> PRT
<213> Homo sapiens
<400> 60
Val Ser Asp Val Pro Arg Asp Leu Gln Ile Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Asp Ile Ser Arg Tyr Lys His Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asp Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Ala Pro Pro Trp Ala Ser Ile Ala Thr Ile Gly Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ala Gln Thr Gly
65                  70                  75                  80  
His His Leu His Asp Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 61
<211> 93
<212> PRT
<213> Homo sapiens
<400> 61
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Pro Thr Ser Asn Pro Pro Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Thr Ile Gly Gly Leu Lys Pro Gly
50                  55                  60                  
Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ala Gln Thr Gly His
65                  70                  75                  80  
His Leu His Asp Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90              
<210> 62
<211> 94
<212> PRT
<213> Homo sapiens
<400> 62
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Cys Trp Arg Pro Thr Ser Asn Pro Pro Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Gly Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ala Gln Thr Gly
65                  70                  75                  80  
His His Leu His Asp Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 63
<211> 94
<212> PRT
<213> Homo sapiens
<400> 63
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Pro Thr Ser Asn Pro Pro Arg Tyr Tyr
20                  25                  30          
Arg Ile Ser Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Gly Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ala Gln Thr Gly
65                  70                  75                  80  
His His Leu His Asp Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 64
<211> 94
<212> PRT
<213> Homo sapiens
<400> 64
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Gln Leu Ile Ser Trp Lys Thr Thr Asn Pro Thr Ala Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Thr Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asn Leu Thr Thr
65                  70                  75                  80  
Arg Arg Arg His Arg Ala Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 65
<211> 94
<212> PRT
<213> Homo sapiens
<400> 65
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Thr Thr Arg His Ser Pro Val Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Ile Val Pro Pro Trp Ala Thr Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Met Pro Thr Asn
65                  70                  75                  80  
Trp Arg Phe Pro His Arg Pro Ile Ser Ile Asp Tyr Arg Thr
85                  90                  
<210> 66
<211> 90
<212> PRT
<213> Homo sapiens
<400> 66
Val Ser Asp Val Pro Arg Asp Leu Glu Ala Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Arg Glu Arg Glu Arg Arg Tyr Tyr Arg Ile Thr Tyr
20                  25                  30          
Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly
35                  40                  45              
Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Glu Pro Gly Val Asp Tyr
50                  55                  60                  
Thr Ile Thr Val Tyr Ala Val Thr Pro His His Gly His Phe Asp Leu
65                  70                  75                  80  
Glu Leu Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90  
<210> 67
<211> 94
<212> PRT
<213> Homo sapiens
<400> 67
Val Ser Asp Val Pro Arg Asp Leu Glu Gly Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Arg Lys Asp Arg Val Ser Ser Arg Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Ile Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Ala Tyr Val Val Thr Pro His His Gly
65                  70                  75                  80  
His Phe Asp Leu Glu Leu Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 68
<211> 95
<212> PRT
<213> Homo spiens
<400> 68
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp His Met Ala Thr Pro Asn Thr Arg Tyr Tyr
20                  25                  30          
Arg Thr Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Asn Thr Asn Thr Val Tyr Ala Val Thr Ser Val Asn
65                  70                  75                  80  
Ala Phe Pro Tyr Glu Gly Met Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  95  
<210> 69
<211> 94
<212> PRT
<213> Homo sapiens
<400> 69
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Ala Thr
1               5                  10                  15      
Ser Leu Leu Ser Ser Trp Tyr Leu Cys Thr Gly Asn Asn Arg Asp Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Ala Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Ile Pro Ser Arg Cys Met Leu Ser Leu Ala Ser Leu
65                  70                  75                  80  
Met Ser Thr Arg Asn Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 70
<211> 94
<212> PRT
<213> Homo sapiens
<400> 70
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Arg Thr Pro Ala Ser Pro His Gly Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Glu Glu Phe
35                  40                  45              
Thr Val Pro Leu Leu Trp Pro Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Ala Ile Thr Val Tyr Ala Val Thr Pro Thr His Met
65                  70                  75                  80  
Leu Lys Pro Leu Ser Met Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 71
<211> 93
<212> PRT
<213> Homo sapiens
<400> 71
Ile Ser Asp Val Pro Arg Asp Met Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Asn Met Ala His Pro His Asp Arg Asn Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Ser
35                  40                  45              
Thr Val Pro Arg Tyr Leu Ser Thr Ala Thr Ile Ser Gly Pro Lys Arg
50                  55                  60                  
Val Asp Tyr Thr Ile Ile Val Tyr Ala Val Asn Gln Pro Thr Val Ser
65                  70                  75                  80  
Ala His Asn His Ala Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90              
<210> 72
<211> 93
<212> PRT
<213> Homo sapiens
<400> 72
Val Ser Asp Val Pro Arg Asp Leu Lys Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Phe Pro Asp Asn Ala Thr Pro Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Leu Phe Thr Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly
50                  55                  60                  
Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ser His Arg Asp Tyr
65                  70                  75                  80  
His Ser Thr Gly Arg Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90              
<210> 73
<211> 95
<212> PRT
<213> Homo sapiens
<400> 73
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Met Leu Leu Arg Asp Asp Arg Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Thr Phe His Pro Thr Ala Thr Ile Ser Gly Arg Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Asn Thr Ile Thr Val Tyr Ala Val Thr Gln Ser Thr
65                  70                  75                  80  
Asn Gly Asn Arg Asn Asp Phe Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  95  
<210> 74
<211> 94
<212> PRT
<213> Homo sapiens
<400> 74
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Ser Pro Pro Asn Asp Ala His Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Asn Thr Val Tyr Ala Val Thr Asp Gln Gln Ser
65                  70                  75                  80  
Tyr Thr Tyr Tyr Ser Asn Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 75
<211> 94
<212> PRT
<213> Homo sapiens
<400> 75
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Val Ile Ser Trp Ser Pro Pro Asn Asp Ala His Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Asn Thr Val Tyr Ala Val Thr Asp Gln Gln Ser
65                  70                  75                  80  
Tyr Thr Tyr Tyr Ser Asn Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 76
<211> 92
<212> PRT
<213> Homo sapiens
<400> 76
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Ser Pro Pro Asn Asp Ala His Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Thr Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Thr Met Pro Thr Asn Trp Arg
65                  70                  75                  80  
Phe Pro His Arg Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90          
<210> 77
<211> 94
<212> PRT
<213> Homo sapiens
<400> 77
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Gln Leu Ile Ser Trp Thr Thr Arg His Ser Pro Val Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Thr Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Met Pro Thr Asn
65                  70                  75                  80  
Trp Arg Phe Pro His Arg Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 78
<211> 94
<212> PRT
<213> Homo sapiens
<400> 78
Val Ser Asp Val Pro Arg Asp Leu Glu Ile Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Gly Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Thr Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ser Asn Val Gly
65                  70                  75                  80  
Arg Leu Asp Thr Arg Tyr Pro Ile Ser Thr Asn Tyr Arg Thr
85                  90                  
<210> 79
<211> 93
<212> PRT
<213> Homo sapiens
<220> 
<221> VARIANT        
<222> 17, 30, 34
<223> Xaa = Any Amino Acid
<400> 79
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Xaa Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Xaa Tyr Tyr
20                  25                  30          
Arg Xaa Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Ile Ser Gly Leu Lys Pro Gly
50                  55                  60                  
Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ser Asn Val Gly Arg
65                  70                  75                  80  
Leu Asp Thr Arg Tyr Pro Ile Phe Ile Asn Tyr Arg Thr
85                  90              
<210> 80
<211> 76
<212> PRT
<213> Homo sapiens
<400> 80
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr
65                  70                  75      
<210> 81
<211> 94
<212> PRT
<213> Homo sapiens
<400> 81
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 82
<211> 94
<212> PRT
<213> Homo sapiens
<400> 82
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Cys Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 83
<211> 94
<212> PRT
<213> Homo sapiens
<400> 83
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Ser Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Pro Thr His Asn
65                  70                  75                  80  
Trp Asn Asp Gln Thr Arg Ser Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 84
<211> 94
<212> PRT
<213> Homo sapiens
<400> 84
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Pro Thr Ser Asn Pro Pro Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Gly Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ala Gln Thr Gly
65                  70                  75                  80  
Tyr His Leu His Asp Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 85
<211> 93
<212> PRT
<213> Homo sapiens
<220> 
<221> VARIANT        
<222> 28, 51, 82
<223> Xaa = Any Amino Acid
<400> 85
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Pro Thr Ser
1               5                  10                  15      
Arg Leu Ile Ser Trp Arg Pro Gly Arg Thr Tyr Xaa Arg Tyr Tyr Arg
20                  25                  30          
Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr
35                  40                  45              
Val Pro Xaa Trp Ala Asn Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly
50                  55                  60                  
Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Phe Pro Pro Gly Tyr
65                  70                  75                  80  
Pro Xaa Thr Glu Met Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90              
<210> 86
<211> 92
<212> PRT
<213> Homo sapiens
<400> 86
Ile Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Arg Arg Trp Pro His Phe Asp Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Thr Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asn Pro Leu Ser
65                  70                  75                  80  
Pro Thr Thr Leu His Pro Pro Ile Asn Tyr Arg Thr
85                  90          
<210> 87
<211> 94
<212> PRT
<213> Homo sapiens
<400> 87
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Lys Pro Arg Arg Thr Asn Thr Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Gly Thr Ile Ala Thr Ile Asn Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Leu Gly Thr Gly
65                  70                  75                  80  
Val Tyr Thr Arg Ala Gln Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 88
<211> 94
<212> PRT
<213> Homo sapiens
<400> 88
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Gln Leu Ile Ser Trp Pro Phe Gly Trp Tyr Pro Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Arg Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr His Phe Pro Glu
65                  70                  75                  80  
Ser Arg Arg Pro Ala Lys Pro Met Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 89
<211> 94
<212> PRT
<213> Homo  sapiens
<400> 89
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp His Thr Glu Arg Ser Phe Pro Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Gly Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Glu His Tyr Arg
65                  70                  75                  80  
Asp Thr Gly Thr Gly His Pro Ile Pro Ile Asn Tyr Arg Thr
85                  90                  
<210> 90
<211> 94
<212> PRT
<213> Homo sapiens
<400> 90
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp His Thr Glu Arg Ser Phe Pro Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Gly Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Glu His Tyr Arg
65                  70                  75                  80  
Asp Thr Gly Thr Gly His Pro Ile Pro Ile Asn Tyr Arg Thr
85                  90                  
<210> 91
<211> 94
<212> PRT
<213> Homo sapiens
<400> 91
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Gln Leu Ile Ser Trp Lys Ser His Thr Phe His Pro Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Thr Ala Ala Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Ala Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Leu Asn Arg Ser
65                  70                  75                  80  
Ser Pro Asn Ser Ala Arg Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 92
<211> 94
<212> PRT
<213> Homo sapiens
<400> 92
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Arg Pro Gln Val Val Ser Thr Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asn His Lys Ala
65                  70                  75                  80  
Asn His His Asp Ala Glu Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 93
<211> 94
<212> PRT
<213> Homo sapiens
<400> 93
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Pro Thr Ser Asn His Pro Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Gly Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Thr Thr Asn Glu
65                  70                  75                  80  
Asp His Val Tyr Ala Leu Pro Ile Ser Ile Asn Tyr Arg Ile
85                  90                  
<210> 94
<211> 94
<212> PRT
<213> Homo sapiens
<400> 94
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Leu
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 95
<211> 94
<212> PRT
<213> Homo sapiens
<400> 95
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Gly Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Met Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 96
<211> 94
<212> PRT
<213> Homo sapiens
<220> 
<221> VARIANT        
<222> 40
<223> Xaa = Any Amino Acid
<400> 96
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Asp Thr His Asn Ala Tyr Asn Gly Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Xaa Gly Asn Ser Pro Val Arg Glu Phe
35                  40                  45              
Thr Val Pro His Pro Glu Val Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Asp Thr Ile Thr Val Tyr Ala Val Thr Asn His His Met
65                  70                  75                  80  
Pro Leu Arg Ile Phe Gly Pro Ile Ser Ile Asn His Arg Thr
85                  90                  
<210> 97
<211> 94
<212> PRT
<213> Homo sapiens
<220> 
<221> VARIANT        
<222> 13, 21
<223> Xaa = Any Amino Acid
<400> 97
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Xaa Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Xaa Trp Thr Arg Thr Asn Ala Asn Thr Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Ala Pro Asn Asn Pro Pro Thr Ala Thr Ile Gly Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Pro Asp Gly Ser
65                  70                  75                  80  
Arg His Met Leu Thr Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 98
<211> 94
<212> PRT
<213> Homo sapiens
<400> 98
Leu Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Ala Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 99
<211> 94
<212> PRT
<213> Homo sapiens
<400> 99
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Leu
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn His Arg Thr
85                  90                  
<210> 100
<211> 94
<212> PRT
<213> Homo sapiens
<400> 100
Val Ser Asp Val Pro Arg Gly Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys His
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 101
<211> 94
<212> PRT
<213> Homo sapiens
<400> 101
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Glu Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Met Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 102
<211> 94
<212> PRT
<213> Homo sapiens
<400> 102
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Thr Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 103
<211> 94
<212> PRT
<213> Homo sapiens
<400> 103
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Ala Asp Lys Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 104
<211> 94
<212> PRT
<213> Homo sapiens
<400> 104
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 105
<211> 94
<212> PRT
<213> Homo sapiens
<400> 105
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Cys Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Gln Arg Asp
65                  70                  75                  80  
Thr Tyr Arg Tyr Asp Asp Pro Ile Ser Thr Asn Cys Arg Thr
85                  90                  
<210> 106
<211> 94
<212> PRT
<213> Homo sapiens
<400> 106
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Asn Ile Tyr Pro Ile Ala Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Ala Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 107
<211> 92
<212> PRT
<213> Homo sapiens
<220> 
<221> VARIANT        
<222> 27
<223> Xaa = Any Amino Acid
<400> 107
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Ala Thr
1               5                  10                  15      
Ser Gln Leu Ile Ser Trp Pro Trp Pro Ser Xaa Pro Thr Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Glu Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Thr Ala Thr Ile Ser Gly Ile Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Ala Val Tyr Ala Val Thr Met Pro Glu Arg
65                  70                  75                  80  
Lys Tyr Asp Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90          
<210> 108
<211> 94
<212> PRT
<213> Homo sapiens
<400> 108
Val Ser Asp Val Ser Arg Asp Leu Glu Ala Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Asn Pro Asn Arg Ser Phe Ala Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Gly Gly Leu Lys Pro
50                  55                  60                  
Arg Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ala Gln Thr Gly
65                  70                  75                  80  
His His Leu His Asp Lys Ser Ile Pro Ile Asn Tyr Arg Thr
85                  90                  
<210> 109
<211> 94
<212> PRT
<213> Homo sapiens
<400> 109
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Pro Gly Arg Thr Tyr Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Ser
35                  40                  45              
Thr Val Pro Pro Trp Ala Asn Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Phe Pro Pro Gly
65                  70                  75                  80  
Tyr Pro Leu Thr Glu Met Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 110
<211> 94
<212> PRT
<213> Homo sapiens
<400> 110
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Ser
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Pro Gly Arg Thr Tyr Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Asn Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Ala Val Tyr Ala Val Thr Phe Pro Thr Gly
65                  70                  75                  80  
Tyr Pro Leu Thr Glu Met Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 111
<211> 94
<212> PRT
<213> Homo sapiens
<400> 111
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Pro Gly Arg Thr Tyr Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Asn Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Ala Tyr Ala Val Thr Tyr Thr His Ser
65                  70                  75                  80  
Thr Pro Met Gln Asp Glu Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 112
<211> 94
<212> PRT
<213> Homo sapiens
<400> 112
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asp Asn Ser Arg Pro Asn Thr Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Gly Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Lys Tyr Thr Ile Thr Val Tyr Ala Val Thr Thr Ser Glu Cys
65                  70                  75                  80  
His Lys Leu Ser Ser Thr Ser Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 113
<211> 91
<212> PRT
<213> Homo sapiens
<400> 113
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Thr Arg Thr Asn Ala Ser Thr Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Asn Phe Trp Trp Ile Ser Gly Leu Lys Pro Gly Val Asp
50                  55                  60                  
Tyr Thr Ile Thr Val Tyr Ala Val Ala Ser Pro Asp Glu Thr Ser Ala
65                  70                  75                  80  
Tyr Ser Glu Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90      
<210> 114
<211> 92
<212> PRT
<213> Homo sapiens
<220> 
<221> VARIANT        
<222> 3, 18, 23
<223> Xaa = Any Amino Acid
<400> 114
Val Ser Xaa Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Xaa Leu Ile Ser Trp Xaa Pro Arg Ser His His Asp Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Gly Thr Ile Ala Thr Ile Asp Gly Leu Lys Pro
50                  55                  60                  
Gly Val Gly Tyr Thr Val Thr Val Tyr Ala Val Thr Asp Asn Pro Asn
65                  70                  75                  80  
Ser Ala Lys Ala Gln His Pro Ile Asn Ser Arg Thr
85                  90          
<210> 115
<211> 94
<212> PRT
<213> Homo sapiens
<400> 115
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Val Ala Thr Pro Thr
1               5                  10                  15      
Ser Gln Leu Ile Ser Trp Met Thr Pro His Asn His Val Arg Tyr Tyr
20                  25                  30          
Gly Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Ser
35                  40                  45              
Thr Val Pro Thr Gly Asn Ala Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Pro His His Gly
65                  70                  75                  80  
His Phe Asp Leu Glu Pro Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 116
<211> 94
<212> PRT
<213> Homo sapiens
<400> 116
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Ser Thr
1               5                  10                  15      
Gly Leu Leu Ile Ser Trp Arg Thr Pro Ala Ser Pro His Gly Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Glu Glu Phe
35                  40                  45              
Thr Val Pro Leu Leu Trp Pro Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Pro Thr His Met
65                  70                  75                  80  
Leu Lys Pro Gln Ser Met Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 117
<211> 94
<212> PRT
<213> Homo sapiens
<400> 117
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Ser Pro Pro Asn Asp Ala His Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Lys Thr Gly Gly Asp Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ser Val Val Tyr Ala Val Thr Asp Gln Gln Ser
65                  70                  75                  80  
Tyr Thr Tyr Tyr Ser Asn Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 118
<211> 94
<212> PRT
<213> Homo sapiens
<220> 
<221> VARIANT        
<222> 28
<223> Xaa = Any Amino Acid
<400> 118
Val Ser Asp Val Pro Ser Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Glu Gln Ser Pro Thr Xaa Gly Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Arg Lys Pro
50                  55                  60                  
Gly Ala Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ile Glu Lys Asp
65                  70                  75                  80  
Arg Ile Pro Leu Phe Gly Pro Ile Ser Ile Ser Tyr Arg Thr
85                  90                  
<210> 119
<211> 94
<212> PRT
<213> Homo sapiens
<400> 119
Val Ser Asp Val Pro Ser Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Glu Gln Ser Pro Thr Tyr Gly Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Arg Lys Pro
50                  55                  60                  
Gly Ala Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ile Glu Lys Asp
65                  70                  75                  80  
Arg Ile Pro Leu Phe Gly Pro Ile Ser Ile Ser Tyr Arg Thr
85                  90                  
<210> 120
<211> 94
<212> PRT
<213> Homo sapiens
<220> 
<221> VARIANT        
<222> 28
<223> Xaa = Any Amino Acid
<400> 120
Val Ser Asp Val Pro Ser Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Glu Gln Ser Pro Thr Xaa Gly Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Arg Lys Pro
50                  55                  60                  
Gly Ala Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ile Glu Lys Asp
65                  70                  75                  80  
Arg Ile Pro Leu Phe Gly Pro Ile Ser Ile Ser Tyr Arg Thr
85                  90                  
<210> 121
<211> 94
<212> PRT
<213> Homo sapiens
<400> 121
Val Pro Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Asp Thr His Asn Ala Tyr Asn Gly Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Ser Ser Pro Ala Gln Glu Phe
35                  40                  45              
Thr Val Pro His Pro Glu Val Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Asp Thr Ile Thr Val Tyr Ala Val Thr Ile His His Met
65                  70                  75                  80  
Pro Leu Arg Ile Phe Gly Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 122
<211> 94
<212> PRT
<213> Homo sapiens
<400> 122
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Glu Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Val Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 123
<211> 94
<212> PRT
<213> Homo sapiens
<400> 123
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Glu Ser Asp
65                  70                  75                  80  
Thr Tyr Lys Tyr Asp Asp Pro Val Ser Thr Asn Tyr Arg Thr
85                  90                  
<210> 124
<211> 94
<212> PRT
<213> Homo sapiens
<400> 124
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Gly Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Pro Asn Val Gly
65                  70                  75                  80  
Arg Leu Asp Thr Arg Tyr Pro Ile Ser Ile Asp Cys Arg Thr
85                  90                  
<210> 125
<211> 94
<212> PRT
<213> Homo sapiens
<220> 
<221> VARIANT        
<222> 86
<223> Xaa = Any Amino Acid
<400> 125
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Asn Arg Ser Gly Leu Gln Ser Arg Tyr Tyr
20                  25                  30          
Arg Thr Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ser Asn Val Gly
65                  70                  75                  80  
Arg Leu Asp Thr Arg Xaa Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 126
<211> 94
<212> PRT
<213> Homo sapiens
<220> 
<221> VARIANT        
<222> 75
<223> Xaa = Any Amino Acid
<400> 126
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Thr Met Pro Val Thr Ala Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asp Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Ala Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Ala Asp Tyr Thr Ile Thr Val Tyr Ala Xaa Thr Ser Ala Thr Pro
65                  70                  75                  80  
Ser Arg Pro Asn Val His Pro Ile Ser Ile Asn Leu Thr Thr
85                  90                  
<210> 127
<211> 88
<212> PRT
<213> Homo sapiens
<400> 127
Val Ser Asp Val Pro Gly Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Gly Trp Ser Met Thr Pro Asn Trp Pro Arg Tyr Tyr
20                  25                  30          
Arg Ile Ala Tyr Gly Glu Thr Gly Gly Asp Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Ile Ile Gly Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr His Arg Asp Thr
65                  70                  75                  80  
Pro Ile Ser Ile Asn Tyr Arg Thr
85              
<210> 128
<211> 90
<212> PRT
<213> Homo sapiens
<400> 128
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Ile
1               5                  10                  15      
Ser Gln Leu Thr Ser Trp Gln Pro Gln Pro Asn Gly Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Ala Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Arg Glu Phe
35                  40                  45              
Thr Val Pro Ala Arg Glu Gln Thr Ala Thr Ser Gly Leu Lys Pro Gly
50                  55                  60                  
Val Asp Tyr Ala Ile Thr Val Tyr Ala Ala Thr His Gly Lys Pro Pro
65                  70                  75                  80  
His Ile His Phe Thr Ile Asn Tyr Arg Thr
85                  90  
<210> 129
<211> 94
<212> PRT
<213> Homo sapiens
<220> 
<221> VARIANT        
<222> 2, 9, 12, 22
<223> Xaa = Any Amino Acid
<400> 129
Val Xaa Asp Val Pro Arg Asp Leu Xaa Val Val Xaa Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Xaa Arg Ser Gly Asn Arg Thr Thr Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Asp Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Met Pro Pro Trp Ala Thr Val Ala Ala Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Thr His Asn Ser
65                  70                  75                  80  
Thr Ala Gln Pro Glu Tyr Pro Ile Pro Phe Asn Arg Arg Thr
85                  90                  
<210> 130
<211> 94
<212> PRT
<213> Homo sapiens
<400> 130
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Pro Gly Arg Thr Tyr Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Asn Thr Ala Thr Ile Ser Cys Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Ala Phe Pro Pro Gly
65                  70                  75                  80  
Tyr Pro Leu Thr Glu Met Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 131
<211> 94
<212> PRT
<213> Homo sapiens
<400> 131
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Pro Gly Arg Ala Tyr Ser Arg Tyr Phe
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Asn Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Ala Val Tyr Ala Val Thr Phe Pro Pro Arg
65                  70                  75                  80  
Tyr Pro Leu Thr Glu Met Pro Ile Ser Ile Asn Tyr Arg Ala
85                  90                  
<210> 132
<211> 94
<212> PRT
<213> Homo sapiens
<400> 132
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Pro Gly Arg Thr Tyr Ser Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Ala Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Asp Lys Ser Gly
65                  70                  75                  80  
Thr Tyr Arg Tyr Asp Asp Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 133
<211> 94
<212> PRT
<213> Homo sapiens
<400> 133
Val Ser Asp Val Pro Arg Asp Leu Arg Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Arg Pro Ala Ser Asn Pro Ala Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Val Ala Thr Ile Gly Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Val Thr Val Tyr Ala Val Thr Ala Gln Thr Gly
65                  70                  75                  80  
His Arg Leu His Asp Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 134
<211> 87
<212> PRT
<213> Homo sapiens
<400> 134
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Ser
1               5                  10                  15      
Leu Leu Ile Ser Trp Arg Pro Pro Ala Asp Leu Asn Arg Tyr Tyr Arg
20                  25                  30          
Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr
35                  40                  45              
Val Pro Pro Trp Gly Thr Val Ala Thr Val Asn Gly Leu Lys Pro Gly
50                  55                  60                  
Val Gly Tyr Thr Ile Thr Val Tyr Ala Val Thr His Arg Asp Thr Pro
65                  70                  75                  80  
Ile Ser Ile Asn Tyr Arg Ala
85          
<210> 135
<211> 93
<212> PRT
<213> Homo sapiens
<400> 135
Val Thr Asp Val Pro Arg Gly Leu Lys Ile Val Ala Ala Thr Pro Ser
1               5                  10                  15      
Leu Leu Ile Ser Trp Arg Asn Ala Lys Asp Pro Gly Arg Tyr Tyr Arg
20                  25                  30          
Ile Thr Tyr Gly Glu Thr Gly Gly Ser Ser Pro Val Gln Glu Phe Thr
35                  40                  45              
Val Pro Pro Trp Gly Thr Ile Ala Ala Ile Asn Gly Leu Lys Pro Gly
50                  55                  60                  
Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ala Thr Asn Pro Gly
65                  70                  75                  80  
Pro Thr Gln His Arg Pro Ile Pro Ile Asn Tyr Arg Thr
85                  90              
<210> 136
<211> 94
<212> PRT
<213> Homo sapiens
<400> 136
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Asp Pro His
1               5                  10                  15      
Gln Pro Leu Ile Cys Trp Ala Ser Pro Pro Met Trp Cys Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Ser Gly Gly Asn Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Thr Ala Ala Ala Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val His Ala Val Thr Asp Glu Ser Trp
65                  70                  75                  80  
Ser Asp Arg Ser Met Asp Pro Ile Ser Ile Asn Cys Arg Thr
85                  90                  
<210> 137
<211> 94
<212> PRT
<213> Homo sapiens
<400> 137
Val Ser Asp Val Pro Arg Asp Leu Lys Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Arg Leu Ile Ser Trp Thr His Asp Asn Val Pro Ala Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Leu
35                  40                  45              
Thr Val Pro Pro Trp Ala Ser Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Leu Tyr Thr Gly
65                  70                  75                  80  
Asn His Arg Pro Glu His Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 138
<211> 93
<212> PRT
<213> Homo sapiens
<400> 138
Val Ser Asp Val Pro Arg Asp Pro Val Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Tyr Arg His Thr Tyr Arg Asp Arg Tyr Tyr
20                  25                  30          
Arg Val Thr Tyr Gly Glu Thr Arg Gly Asn Ser Pro Ile Arg Glu Phe
35                  40                  45              
Thr Val Pro Pro Trp Ala Thr Ile Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Ala Val Tyr Ala Val Thr Asp Ala Gly Tyr
65                  70                  75                  80  
Asp Val His Thr Lys Arg Pro Ile Ser Ile Asn Arg Thr
85                  90              
<210> 139
<211> 94
<212> PRT
<213> Homo sapiens
<400> 139
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Gly Leu Leu Ile Ser Trp Arg Asn Asn Gln Tyr Thr Pro Arg His Tyr
20                  25                  30          
Gly Ile Thr Tyr Gly Glu Thr Gly Gly Lys Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Glu Leu Asn Pro Thr Ala Thr Ile Ser Arg Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gln Asn Gly Thr
65                  70                  75                  80  
Pro Arg Val Ile Tyr Gly Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 140
<211> 89
<212> PRT
<213> Homo sapiens
<400> 140
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Asn Val Pro Ile Ile Arg Tyr Tyr Arg Ile Thr Tyr Gly
20                  25                  30          
Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Ala Pro
35                  40                  45              
Lys Ala Ile Ala Thr Thr Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr
50                  55                  60                  
Ile Thr Val Tyr Gly Val Thr Ser His Arg Asn His Phe His Val Glu
65                  70                  75                  80  
Thr Pro Ile Ser Ile Asn Tyr Gln Ala
85                  
<210> 141
<211> 21
<212> PRT
<213> Homo sapiens
<400> 141
Asp Ala Pro Ala Val Thr Val Gly Ser Lys Ser Gly Arg Gly Asp Ser
1               5                  10                  15      
Pro Ala Ser Ser Lys
20      
<210> 142
<211> 21
<212> PRT
<213> Homo sapiens
<400> 142
Ala Ser Pro Pro Met Trp Cys Pro Trp Ala Thr Glu Tyr Leu Pro Glu
1               5                  10                  15      
Trp Asn Met Thr Gln
20      
<210> 143
<211> 21
<212> PRT
<213> Homo sapiens
<400> 143
Asn Arg Ser Gly Leu Gln Ser Pro Trp Ala Ser Asp Lys Ser Asp Thr
1               5                  10                  15      
Tyr Lys Tyr Asp Asp
20      
<210> 144
<211> 21
<212> PRT
<213> Homo sapiens
<400> 144
Arg Pro Thr Ser Asn Pro Pro Pro Trp Ala Ser Ala Gln Thr Gly His
1               5                  10                  15      
His Leu His Asp Lys
20      
<210> 145
<211> 21
<212> PRT
<213> Homo sapiens
<400> 145
His Thr Glu Arg Ser Phe Pro Pro Trp Gly Ser Glu His Tyr Arg Asp
1               5                  10                  15      
Thr Gly Thr Gly His
20      
<210> 146
<211> 21
<212> PRT
<213> Homo sapiens
<400> 146
Thr Thr Arg His Ser Pro Val Pro Trp Ala Thr Met Pro Thr Asn Trp
1               5                  10                  15      
Arg Phe Pro His Arg
20      
<210> 147
<211> 21
<212> PRT
<213> Homo sapiens
<400> 147
Arg Pro Asn Pro Arg Leu Ser Gly Leu Phe Ser Pro Lys Glu Thr Ser
1               5                  10                  15      
Asn Ile Phe Ile Ala
20      
<210> 148
<211> 21
<212> PRT
<213> Homo sapiens
<400> 148
Ser Pro Pro Asn Asp Ala His Gly Ser Lys Ser Asp Gln Gln Ser Tyr
1               5                  10                  15      
Thr Tyr Tyr Ser Asn
20      
<210> 149
<211> 21
<212> PRT
<213> Homo sapiens
<400> 149
Arg Thr Pro Ala Ser Pro His Leu Leu Trp Pro Pro Thr His Met Leu
1               5                  10                  15      
Lys Pro Gln Ser Met
20      
<210> 150
<211> 21
<212> PRT
<213> Homo sapiens
<400> 150
Tyr Arg His Thr Tyr Arg Asp Pro Trp Ala Thr Asp Thr Gly Tyr Asp
1               5                  10                  15      
Val His Thr Lys Arg
20      
<210> 151
<211> 21
<212> PRT
<213> Homo sapiens
<400> 151
Asn Arg Ser Gly Leu Gln Ser Pro Trp Ala Ser Ser Asn Val Gly Arg
1               5                  10                  15      
Leu Asp Thr Arg Tyr
20      
<210> 152
<211> 21
<212> PRT
<213> Homo sapiens
<400> 152
Asp Thr His Asn Ala Tyr Asn His Pro Glu Val Asn His His Met Pro
1               5                  10                  15      
Leu Arg Ile Phe Gly
20      
<210> 153
<211> 21
<212> PRT
<213> Homo sapiens
<400> 153
Arg Pro Thr Ser Asn Pro Pro Pro Trp Ala Ser Pro Val Tyr Pro Met
1               5                  10                  15      
His Ser Met Leu Ser
20      
<210> 154
<211> 21
<212> PRT
<213> Homo sapiens
<400> 154
Arg Asn Ile Tyr Pro Ile Ala Pro Trp Ala Ser Asp Lys Ser Asp Thr
1               5                  10                  15      
Tyr Lys Tyr Asp Asp
20      
<210> 155
<211> 21
<212> PRT
<213> Homo sapiens
<400> 155
Asn Arg Ser Gly Leu Gln Cys Pro Trp Ala Ser Asp Gln Arg Asp Thr
1               5                  10                  15      
Tyr Lys Tyr Asp Asp
20      
<210> 156
<211> 21
<212> PRT
<213> Homo sapiens
<400> 156
Arg Pro Gly Arg Thr Tyr Ser Pro Trp Ala Asn Phe Pro Thr Gly Tyr
1               5                  10                  15      
Pro Leu Thr Glu Met
20      
<210> 157
<211> 21
<212> PRT
<213> Homo sapiens
<400> 157
Arg Pro Gly Arg Thr Tyr Ser Pro Trp Ala Asn Phe Pro Pro Gly Tyr
1               5                  10                  15      
Pro Leu Thr Glu Met
20      
<210> 158
<211> 21
<212> PRT
<213> Homo sapiens
<400> 158
Met Thr Pro His Asn His Val Thr Gly Asn Ala Pro His His Gly His
1               5                  10                  15      
Phe Asp Leu Glu Pro
20      
<210> 159
<211> 21
<212> PRT
<213> Homo sapiens
<400> 159
Thr Arg Thr Asn Ala Ser Thr Asn Phe Trp Trp Ser Pro Asp Glu Thr
1               5                  10                  15      
Ser Ala Tyr Ser Glu
20      
<210> 160
<211> 21
<212> PRT
<213> Homo sapiens
<400> 160
Asn Arg Ser Gly Leu Gln Ser Pro Trp Ala Ser Asp Lys Ser Asp Thr
1               5                  10                  15      
Tyr Lys Tyr Asp Asp
20      
<210> 161
<211> 21
<212> PRT
<213> Homo sapiens
<400> 161
Arg Pro Gly Arg Thr Tyr Ser Pro Trp Ala Asn Tyr Thr His Ser Thr
1               5                  10                  15      
Pro Met Gln Asp Glu
20      
<210> 162
<211> 21
<212> PRT
<213> Homo sapiens
<400> 162
Arg Thr Pro Ala Ser Pro His Leu Leu Trp Pro Pro Thr His Met Leu
1               5                  10                  15      
Lys Pro Gln Ser Met
20      
<210> 163
<211> 21
<212> PRT
<213> Homo sapiens
<400> 163
Thr Arg Thr Asn Ala Asn Thr Asn Asn Pro Pro Pro Asp Gly Ser Arg
1               5                  10                  15      
His Met Leu Thr Lys
20      
<210> 164
<211> 21
<212> PRT
<213> Homo sapiens
<400> 164
Asp Asn Ser Arg Pro Asn Thr Pro Trp Gly Ser Thr Ser Glu Cys His
1               5                  10                  15      
Lys Leu Ser Ser Thr
20      
<210> 165
<211> 21
<212> PRT
<213> Homo sapiens
<400> 165
Asn Pro Asn Arg Ser Phe Ala Pro Trp Ala Ser Ala Gln Thr Gly His
1               5                  10                  15      
His Leu His Asp Lys
20      
<210> 166
<211> 15
<212> PRT
<213> Homo sapiens
<400> 166
Ser Met Thr Pro Asn Trp Pro Pro Trp Ala Ser His Arg Asp Thr
1               5                  10                  15  
<210> 167
<211> 21
<212> PRT
<213> Homo sapiens
<400> 167
Asp Thr His Asn Ala Tyr Asn His Pro Glu Val Ile His His Met Pro
1               5                  10                  15      
Leu Arg Ile Phe Gly
20      
<210> 168
<211> 20
<212> PRT
<213> Homo sapiens
<400> 168
Ala Ser Pro Pro Met Trp Pro Trp Ala Thr Asp Glu Ser Trp Ser Asp
1               5                  10                  15      
Arg Ser Met Asp
20  
<210> 169
<211> 15
<212> PRT
<213> Homo sapiens
<400> 169
Arg Pro Pro Ala Asp Leu Asn Pro Trp Gly Thr His Arg Asp Thr
1               5                  10                  15  
<210> 170
<211> 21
<212> PRT
<213> Homo sapiens
<400> 170
Glu Gln Ser Pro Thr Tyr Gly Gly Ser Lys Ser Ile Glu Lys Asp Arg
1               5                  10                  15      
Ile Pro Leu Phe Gly
20      
<210> 171
<211> 21
<212> PRT
<213> Homo sapiens
<400> 171
Arg Pro Gly Arg Thr Tyr Ser Pro Trp Ala Asn Phe Pro Pro Gly Tyr
1               5                  10                  15      
Pro Leu Thr Glu Met
20      
<210> 172
<211> 21
<212> PRT
<213> Homo sapiens
<400> 172
Arg Pro Gly Arg Thr Tyr Ser Pro Trp Ala Ser Asp Lys Ser Gly Thr
1               5                  10                  15      
Tyr Arg Tyr Asp Asp
20      
<210> 173
<211> 21
<212> PRT
<213> Homo sapiens
<400> 173
Tyr Arg His Thr Tyr Arg Asp Pro Trp Ala Thr Asp Ala Gly Tyr Asp
1               5                  10                  15      
Val His Thr Lys Arg
20      
<210> 174
<211> 21
<212> PRT
<213> Homo sapiens
<400> 174
Arg Thr Met Pro Val Thr Ala Pro Trp Ala Ser Ser Ala Thr Pro Ser
1               5                  10                  15      
Arg Pro Asn Val His
20      
<210> 175
<211> 21
<212> PRT
<213> Homo sapiens
<400> 175
Arg Pro Gly Arg Ala Tyr Ser Pro Trp Ala Asn Phe Pro Pro Arg Tyr
1               5                  10                  15      
Pro Leu Thr Glu Met
20      
<210> 176
<211> 21
<212> PRT
<213> Homo sapiens
<400> 176
Ser Pro Pro Asn Asp Ala His Gly Ser Lys Ser Asp Gln Gln Ser Tyr
1               5                  10                  15      
Thr Tyr Tyr Ser Asn
20      
<210> 177
<211> 16
<212> PRT
<213> Homo sapiens
<400> 177
Ile Ile Ala Pro Lys Ala Ser His Arg Asn His Phe His Val Glu Thr
1               5                  10                  15      
<210> 178
<211> 21
<212> PRT
<213> Homo sapiens
<400> 178
Arg Asn Asn Gln Tyr Thr Pro Glu Leu Asn Pro Gln Asn Gly Thr Pro
1               5                  10                  15      
Arg Val Ile Tyr Gly
20      
<210> 179
<211> 21
<212> PRT
<213> Homo sapiens
<400> 179
Arg Pro Ala Ser Asn Pro Ala Pro Trp Ala Ser Ala Gln Thr Gly His
1               5                  10                  15      
Arg Leu His Asp Lys
20      
<210> 180
<211> 21
<212> PRT
<213> Homo sapiens
<400> 180
Asn Arg Ser Gly Leu Gln Ser Pro Trp Ala Ser Pro Asn Val Gly Arg
1               5                  10                  15      
Leu Asp Thr Arg Tyr
20      
<210> 181
<211> 21
<212> PRT
<213> Homo sapiens
<400> 181
Asn Arg Ser Gly Leu Gln Ser Pro Trp Ala Ser Asp Glu Ser Asp Thr
1               5                  10                  15      
Tyr Lys Tyr Asp Asp
20      
<210> 182
<211> 21
<212> PRT
<213> Homo sapiens
<400> 182
Thr His Asp Asn Val Pro Ala Pro Trp Ala Ser Leu Tyr Thr Gly Asn
1               5                  10                  15      
His Arg Pro Glu His
20      
<210> 183
<211> 21
<212> PRT
<213> Homo sapiens
<400> 183
Arg Ser Gly Asn Arg Thr Thr Pro Trp Ala Thr Thr His Asn Ser Thr
1               5                  10                  15      
Ala Gln Pro Glu Tyr
20      
<210> 184
<211> 21
<212> PRT
<213> Homo sapiens
<400> 184
Asn Arg Ser Gly Leu Gln Ser Pro Trp Ala Ser Ser Asn Val Gly Arg
1               5                  10                  15      
Leu Asp Thr Arg Tyr
20      
<210> 185
<211> 21
<212> PRT
<213> Homo sapiens
<400> 185
Arg Asn Ala Lys Asp Pro Gly Pro Trp Gly Thr Ala Thr Asn Pro Gly
1               5                  10                  15      
Pro Thr Gln His Arg
20      
<210> 186
<211> 94
<212> PRT
<213> Bovis taurus
<400> 186
Val Ser Asp Val Pro Arg Asp Leu Glu Val Ile Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Ser Ser Pro Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp
65                  70                  75                  80  
Ser Pro Ala Ser Ser Lys Pro Val Ser Ile Asn Tyr Arg Thr
85                  90                  
<210> 187
<211> 92
<212> PRT
<213> Rattus norvegicus
<400> 187
Val Ser Asp Val Pro Arg Asp Leu Glu Val Ile Ala Ser Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Glu Pro Ala Val Ser Val Arg Tyr Tyr Arg
20                  25                  30          
Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr
35                  40                  45              
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Asn Ile Lys Pro Gly Ala
50                  55                  60                  
Asp Tyr Thr Ile Thr Leu Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro
65                  70                  75                  80  
Ala Ser Ser Lys Pro Val Ser Ile Asn Tyr Gln Thr
85                  90          
<210> 188
<211> 92
<212> PRT
<213> Mus musculus
<400> 188
Val Ser Asp Ile Pro Arg Asp Leu Glu Val Ile Ala Ser Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Glu Pro Ala Val Ser Val Arg Tyr Tyr Arg
20                  25                  30          
Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr
35                  40                  45              
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Asn Ile Lys Pro Gly Ala
50                  55                  60                  
Asp Tyr Thr Ile Thr Leu Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro
65                  70                  75                  80  
Ala Ser Ser Lys Pro Val Ser Ile Asn Tyr Lys Thr
85                  90          
<210> 189
<211> 40
<212> PRT
<213> Oryctolagus cuniculuc
<220> 
<221> VARIANT        
<222> 24
<223> Xaa = Any Amino Acid
<400> 189
Val Ser Asp Val Pro Arg Asp Leu Glu Val Ile Ala Ser Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Ile Ser Trp Glu Xaa Pro Ala Val Thr Val Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Asn
35                  40  
<210> 190
<211> 92
<212> PRT
<213> Gallus gallus
<400> 190
Val Ser Asp Val Pro Arg Asp Leu Glu Val Asn Thr Ser Pro Thr Ser
1               5                  10                  15      
Leu Glu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr Arg
20                  25                  30          
Ile Thr Tyr Gly Glu Thr Gly Gly Ser Ser Pro Val Gln Glu Phe Thr
35                  40                  45              
Val Pro Gly Thr Met Ser Ala Thr Ile Thr Gly Leu Lys Pro Gly Val
50                  55                  60                  
Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro
65                  70                  75                  80  
Ala Ser Ser Lys Pro Val Thr Val Thr Tyr Lys Thr
85                  90          
<210> 191
<211> 93
<212> PRT
<213> Xenupus laevis
<400> 191
Val Ser Asp Val Pro Thr Asp Leu Glu Val Thr Ser Ser Ser Pro Asn
1               5                  10                  15      
Thr Leu Thr Ile Ser Trp Glu Ala Pro Ala Val Ser Val Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Ser Gln Thr Gly Gly Gly Pro Glu Lys Glu Phe Thr
35                  40                  45              
Val Pro Gly Thr Ser Asn Thr Ala Thr Ile Arg Gly Leu Asn Pro Gly
50                  55                  60                  
Val Ser Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp Ser
65                  70                  75                  80  
Pro Ala Ser Ser Lys Pro Leu Thr Ile Ile His Lys Thr
85                  90              
<210> 192
<211> 68
<212> PRT
<213> Canis familiaris
<400> 192
Ala Asp Ala Pro Ser Leu Phe Leu Ala Thr Thr Pro Ser Leu Leu Val
1               5                  10                  15      
Ser Trp Gln Pro Ala Ile Thr Gly Tyr Ile Ile Lys Tyr Gly Ser Glu
20                  25                  30          
Val Val Pro Gly Val Thr Ala Thr Ile Thr Gly Leu Pro Gly Thr Glu
35                  40                  45              
Tyr Thr Ile Gln Val Ile Ala Leu Lys Asn Gln Lys Ser Leu Ile Gly
50                  55                  60                  
Lys Thr Glu Leu
65              
<210> 193
<211> 67
<212> PRT
<213> Equus caballis
<400> 193
Ala Asp Ala Pro Ser Leu Phe Leu Ala Thr Thr Pro Ser Leu Leu Ile
1               5                  10                  15      
Ser Trp Gln Pro Ala Ile Thr Gly Tyr Ile Ile Lys Tyr Gly Ser Glu
20                  25                  30          
Val Val Pro Gly Val Thr Ala Thr Ile Thr Gly Leu Pro Gly Thr Glu
35                  40                  45              
Tyr Thr Ile Gln Val Ile Ala Ile Lys Asn Gln Lys Ser Leu Ile Gly
50                  55                  60                  
Lys Thr Glu
65          
<210> 194
<211> 70
<212> PRT
<213> Homo sapiens
<400> 194
Val Ser Pro Pro Lys Asp Leu Val Thr Val Thr Thr Val Asn Leu Ala
1               5                  10                  15      
Trp Asp Met Val Thr Tyr Leu Val Val Tyr Thr Pro Thr His Glu Gly
20                  25                  30          
Gly Glu Met Gln Phe Val Pro Gly Asp Gln Thr Ser Thr Ile Ile Gln
35                  40                  45              
Leu Pro Gly Val Glu Tyr Phe Ile Arg Val Phe Ala Ile Leu Asn Lys
50                  55                  60                  
Lys Ser Val Ser Ala Val
65                  70  
<210> 195
<211> 69
<212> PRT
<213> Sus scrofa
<400> 195
Val Ser Pro Pro Lys Asp Leu Val Thr Val Thr Thr Val Asn Leu Ala
1               5                  10                  15      
Trp Asp Met Val Thr Tyr Leu Ile Val Tyr Thr Pro Thr His Glu Gly
20                  25                  30          
Glu Met Gln Phe Val Pro Gly Asp Gln Thr Ser Thr Thr Ile Arg Leu
35                  40                  45              
Pro Gly Val Glu Tyr Phe Ile Arg Val Phe Ala Ile Leu Asn Lys Lys
50                  55                  60                  
Ser Val Ser Ala Val
65                  
<210> 196
<211> 75
<212> PRT
<213> Mus musculus
<400> 196
Met Asp Gly Pro Gln Asp Leu Val Val Ala Val Thr Pro Thr Thr Leu
1               5                  10                  15      
Asp Leu Ser Trp Pro Gln Ala Val Asp Phe Val Val Ser Tyr Val Ser
20                  25                  30          
Ala Gly Asn Arg Val Leu Val Pro Pro Glu Ala Asp Thr Gln Leu Thr
35                  40                  45              
Leu Met Pro Gly Val Glu Tyr Val Val Thr Val Thr Ala Glu Arg Gly
50                  55                  60                  
His Ala Val Ser Ala Ser Ile Ala Asn Thr Gly
65                  70                  75  
<210> 197
<211> 69
<212> PRT
<213> Homo sapiens
<400> 197
Thr Val Pro Ser Leu Ile Tyr Val Gly Pro Thr Thr Met His Val Gln
1               5                  10                  15      
Trp Gln Val Gly Gly Ala Thr Gly Tyr Ile Leu Ser Tyr Pro Val Asp
20                  25                  30          
Thr Glu Thr Lys Glu Val Leu Gly Pro Thr Val Asn Met Gln Leu Thr
35                  40                  45              
Leu Val Pro Asn Thr Glu Tyr Ala Val Thr Val Gln Ala Val Leu Leu
50                  55                  60                  
Thr Ser Val Thr Val
65                  
<210> 198
<211> 44
<212> PRT
<213> Oryctolagus cuniculus
<400> 198
Thr Val Pro Ser Leu Asn Ile Tyr Val Gly Pro Thr Thr Met His Val
1               5                  10                  15      
Gln Trp Gln Val Gly Gly Ala Thr Gly Tyr Ile Leu Ser Tyr Pro Val
20                  25                  30          
Asp Thr Glu Thr Lys Gln Val Leu Arg Val Thr His
35                  40                  
<210> 199
<211> 66
<212> PRT
<213> Gallus gallus
<400> 199
Leu Ser Asp Leu Leu Tyr Val Ser Ser Ser Met Arg Ala Lys Trp Gly
1               5                  10                  15      
Val Ala Gly Ala Thr Gly Tyr Met Ile Leu Tyr Ala Pro Leu Thr Glu
20                  25                  30          
Gly Leu Ala Ala Glu Lys Glu Ile Ile Gly Glu Ala Ser Thr Leu Glu
35                  40                  45              
Leu Asp Gly Leu Leu Pro Asn Thr Glu Tyr Thr Val Thr Val Tyr Ala
50                  55                  60                  
Met Phe
65      
<210> 200
<211> 72
<212> PRT
<213> Homo sapiens
<400> 200
Leu Ser Asp Leu Leu Tyr Val Thr Ser Met Arg Val Lys Trp Asp Ala
1               5                  10                  15      
Val Gly Ala Ser Gly Tyr Leu Ile Leu Tyr Ala Pro Leu Thr Glu Gly
20                  25                  30          
Leu Ala Gly Glu Lys Glu Met Ile Gly Glu Thr His Thr Ile Glu Leu
35                  40                  45              
Ser Gly Leu Leu Pro Asn Thr Glu Tyr Thr Val Thr Val Tyr Ala Met
50                  55                  60                  
Phe Gly Ala Ser Asp Val Thr Gly
65                  70          
<210> 201
<211> 117
<212> PRT
<213> Lama glama
<400> 201
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Gly Ser Thr Tyr
20                  25                  30          
Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val
35                  40                  45              
Ala Ala Ile Asn Trp Asp Ser Ala Arg Thr Tyr Tyr Ala Ser Ser Val
50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Thr Cys
85                  90                  95      
Gly Ala Gly Glu Gly Gly Thr Trp Asp Ser Trp Gly Gln Gly Thr Gln
100                 105                 110         
Val Thr Val Ser Ser
115         
<210> 202
<211> 94
<212> PRT
<213> Homo sapiens
<400> 202
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr
1               5                  10                  15      
Ser Leu Leu Phe Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr
20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Leu Val Gln Glu Phe
35                  40                  45              
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50                  55                  60                  
Gly Val Asp Tyr Thr Ile Thr Gly Tyr Ala Val Thr Gly Arg Gly Asp
65                  70                  75                  80  
Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85                  90