【手続補正書】
【提出日】平成16年10月20日(2004.10.20)
【手続補正１】
【補正対象書類名】明細書
【補正対象項目名】０１９４
【補正方法】変更
【補正の内容】
【０１９４】
【図１】本発明のキナーゼタンパク質をコードするcDNA分子、または転写産物のヌクレオチド配列を示す（配列番号：1）。さらに、ATG開始、終結、及び組織分布のような構造及び機能情報が利用可能に提供され、この分子配列に基づく本発明の特定用途を容易に決定することが可能となる。図1の実験データにより、ヒトの胎盤、腎臓、肺、骨格筋、心臓、胎児脳、及び大腸癌における発現が示されている。
【図２】本発明のキナーゼの推定アミノ酸配列を示す（配列番号：2）。さらに、タンパク質ファミリー、機能、及び修飾部位のような構造及び機能情報が利用可能に提供され、この分子配列に基づく本発明の特定用途を容易に決定することが可能となる。
【図３】本発明のキナーゼタンパク質をコードする遺伝子のゲノム配列を示す（配列番号：3）。さらに、イントロン/エクソン構造、プロモーター位置などのような構造及び機能情報が利用可能に提供され、この分子配列に基づく本発明の特定用途を容易に決定することが可能となる。本発明により提供されるキナーゼタンパク質をコードする遺伝子中に6個のSNPが同定され、それらは図3に示されている。
【配列表】
SEQUENCE LISTING
<110> PE CORPORATION (NY)
<120> ISOLATED HUMAN KINASE PROTEINS,
NUCLEIC ACID MOLECULES ENCODING HUMAN KINASE PROTEINS,
AND USES THEREOF
<130> CG-A0301
<140> JP   2002-542996
<141> 2001-10-22
<150> US   09/858,664
<151> 2001-05-17
<150> US   09/711,134
<151> 2000-11-14
<160> 34
<170> FastSEQ for Windows Version 4.0
<210> 1
<211> 5207
<212> DNA
<213> Homo sapiens
<400> 1
cagcacgagg aactccttct gatcacctgg ccagctgagg tcagagtggg agaggcagtg 60
gttccattga aggagtactc ctaactgtca gaagcctggg cggtcaggat ggggtgctgt 120
cgcttgggct gcggggggtg ttcagttgcc cacagtgtat ctcagggtct caccaaccat 180
ccaagcatgg taggctgtgg ctggcaccca gggttgtgtg gctggggagg tggtctccac 240
agttccctcc ctgccctccc agggccccca tccatgcagg taaccatcga ggatgtgcag 300
gcacagacag gcggaacggc ccaattcgag gctatcattg agggcgaccc acagccctcg 360
gtgacctggt acaaggacag cgtccagctg gtggacagca cccggcttag ccagcagcaa 420
gaaggcacca catactccct ggtgctgagg catgtggcct cgaaggatgc cggcgtttac 480
acctgcctgg cccaaaacac tggtggccag gtgctctgca aggcagagct gctggtgctt 540
gggggggaca atgagccgga ctcagagaag caaagccacc ggaggaagct gcactccttc 600
tatgaggtca aggaggagat tggaaggggc gtgtttggct tcgtaaaaag agtgcagcac 660
aaaggaaaca agatcttgtg cgctgccaag ttcatccccc tacggagcag aactcgggcc 720
caggcataca gggagcgaga catcctggcc gcgctgagcc acccgctggt cacggggctg 780
ctggaccagt ttgagacccg caagaccctc atcctcatcc tggagctgtg ctcatccgag 840
gagctgctgg accgcctgta caggaagggc gtggtgacgg aggccgaggt caaggtctac 900
atccagcagc tggtggaggg gctgcactac ctgcacagcc atggcgttct ccacctggac 960
ataaagccct ctaacatcct gatggtgcat cctgcccggg aagacattaa aatctgcgac 1020
tttggctttg cccagaacat caccccagca gagctgcagt tcagccagta cggctcccct 1080
gagttcgtct cccccgagat catccagcag aaccctgtga gcgaagcctc cgacatttgg 1140
gccatgggtg tcatctccta cctcagcctg acctgctcat ccccatttgc cggcgagagt 1200
gaccgtgcca ccctcctgaa cgtcctggag gggcgcgtgt catggagcag ccccatggct 1260
gcccacctca gcgaagacgc caaagacttc atcaaggcta cgctgcagag agcccctcag 1320
gcccggccta gtgcggccca gtgcctctcc cacccctggt tcctgaaatc catgcctgcg 1380
gaggaggccc acttcatcaa caccaagcag ctcaagttcc tcctggcccg aagtcgctgg 1440
cagcgttccc tgatgagcta caagtccatc ctggtgatgc gctccatccc tgagctgctg 1500
cggggcccac ccgacagccc ctccctcggc gtagcccggc acctctgcag ggacactggt 1560
ggctcctcca gttcctcctc ctcctctgac aacgagctcg ccccatttgc ccgggctaag 1620
tcactgccac cctccccggt gacacactca ccactgctgc acccccgggg cttcctgcgg 1680
ccctcggcca gcctgcctga ggaagccgag gccagtgagc gctccaccga ggccccagct 1740
ccgcctgcat ctcccgaggg tgccgggcca ccggccgccc agggctgcgt gccccggcac 1800
agcgtcatcc gcagcctgtt ctaccaccag gcgggtgaga gccctgagca cggggccctg 1860
gccccgggga gcaggcggca cccggcccgg cggcggcacc tgctgaaggg cggctacatt 1920
gcgggggcgc tgccaggcct gcgcgagcca ctgatggagc accgcgtgct ggaggaggag 1980
gccgccaggg aggagcaggc caccctcctg gccaaagccc cctcattcga gactgccctc 2040
cggctgcctg cctctggcac ccacttggcc cctggccaca gccactccct ggaacatgac 2100
tctccgagca ccccccgccc ctcctcggag gcctgcggtg aggcacagcg actgccttca 2160
gccccctccg ggggggcccc tatcagggac atggggcacc ctcagggctc caagcagctt 2220
ccatccactg gtggccaccc aggcactgct cagccagaga ggccatcccc ggacagccct 2280
tgggggcagc cagccccttt ctgccacccc aagcagggtt ctgcccccca ggagggctgc 2340
agcccccacc cagcagttgc cccatgccct cctggctcct tccctccagg atcttgcaaa 2400
gaggccccct tagtaccctc aagccccttc ttgggacagc cccaggcacc ccctgcccct 2460
gccaaagcaa gccccccatt ggactctaag atggggcctg gagacatctc tcttcctggg 2520
aggccaaaac ccggcccctg cagttcccca gggtcagcct cccaggcgag ctcttcccaa 2580
gtgagctccc tcagggtggg ctcctcccag gtgggcacag agcctggccc ctccctggat 2640
gcggagggct ggacccagga ggctgaggat ctgtccgact ccacacccac cttgcagcgg 2700
cctcaggaac aggtgaccat gcgcaagttc tccctgggtg gtcgcggggg ctacgcaggc 2760
gtggctggct atggcacctt tgcctttggt ggagatgcag ggggcatgct ggggcagggg 2820
cccatgtggg ccaggatagc ctgggctgtg tcccagtcgg aggaggagga gcaggaggag 2880
gccagggctg agtcccagtc ggaggagcag caggaggcca gggctgagag cccactgccc 2940
caggtcagtg caaggcctgt gcctgaggtc ggcagggctc ccaccaggag ctctccagag 3000
cccaccccat gggaggacat cgggcaggtc tccctggtgc agatccggga cctgtcaggt 3060
gatgcggagg cggccgacac aatatccctg gacatttccg aggtggaccc cgcctacctc 3120
aacctctcag acctgtacga tatcaagtac ctcccattcg agtttatgat cttcaggaaa 3180
gtccccaagt ccgctcagcc agagccgccc tcccccatgg ctgaggagga gctggccgag 3240
ttcccggagc ccacgtggcc ctggccaggt gaactgggcc cccacgcagg cctggagatc 3300
acagaggagt cagaggatgt ggacgcgctg ctggcagagg ctgccgtggg caggaagcgc 3360
aagtggtcct cgccgtcacg cagcctcttc cacttccctg ggaggcacct gccgctggat 3420
gagcctgcag agctggggct gcgtgagaga gtgaaggcct ccgtggagca catctcccgg 3480
atcctgaagg gcaggccgga aggtctggag aaggaggggc cccccaggaa gaagccaggc 3540
cttgcttcct tccggctctc aggtctgaag agctgggacc gagcgccgac attcctaagg 3600
gagctctcag atgagactgt ggtcctgggc cagtcagtga cactggcctg ccaggtgtca 3660
gcccagccag ctgcccaggc cacctggagc aaagacggag cccccctgga gagcagcagc 3720
cgtgtcctca tctctgccac cctcaagaac ttccagcttc tgaccatcct ggtggtggtg 3780
gctgaggacc tgggtgtgta cacctgcagc gtgagcaatg cgctggggac agtgaccacc 3840
acgggcgtcc tccggaaggc agagcgcccc tcatcttcgc catgcccgga tatcggggag 3900
gtgtacgcgg atggggtgct gctggtctgg aagcccgtgg aatcctacgg ccctgtgacc 3960
tacattgtgc agtgcagcct agaaggcggc agctggacca cactggcctc cgacatcttt 4020
gactgctgct acctgaccag caagctctcc cggggtggca cctacacctt ccgcacggca 4080
tgtgtcagca aggcaggaat gggtccctac agcagcccct cggagcaagt cctcctggga 4140
gggcccagcc acctggcctc tgaggaggag agccaggggc ggtcagccca acccctgccc 4200
agcacaaaga ccttcgcatt ccagacacag atccagaggg gccgcttcag cgtggtgcgg 4260
caatgctggg agaaggccag cgggcgggcg ctggccgcca agatcatccc ctaccacccc 4320
aaggacaaga cagcagtgct gcgcgaatac gaggccctca agggcctgcg ccacccgcac 4380
ctggcccagc tgcacgcagc ctacctcagc ccccggcacc tggtgctcat cttggagctg 4440
tgctctgggc ccgagctgct cccctgcctg gccgagaggg cctcctactc agaatctgag 4500
gtgaaggact acctgtggca gatgttgagt gccacccagt acctgcacaa ccagcacatc 4560
ctgcacctgg acctgaggtc cgagaacatg atcatcaccg aatacaacct gctcaaggtc 4620
gtggacctgg gcaatgcaca gagcctcagc caggagaagg tgctgccctc agacaagttc 4680
aaggactacc tagagaccat ggctccagag ctcctggagg gccagggggc tgttccacag 4740
acagacatct gggccatcgg tgtgacagcc ttcatcatgc tgagcgccga gtacccggtg 4800
agcagcgagg gtgcacgcga cctgcagaga ggactgcgca aggggctggt ccggctgagc 4860
cgctgctacg cggggctgtc cgggggcgcc gtggccttcc tgcgcagcac tctgtgcgcc 4920
cagccctggg gccggccctg cgcgtccagc tgcctgcagt gcccgtggct aacagaggag 4980
ggcccggcct gttcgcggcc cgcgcccgtg accttcccta ccgcgcggct gcgcgtcttc 5040
gtgcgcaatc gcgagaagag acgcgcgctg ctgtacaaga ggcacaacct ggcccaggtg 5100
cgctgagggt cgccccggcc acacccttgg tctccccgct gggggtcgct gcagacgcgc 5160
caataaaaac gcacagccgg gcgagaaaaa aaaaaaaaaa aaaaaaa               5207
<210> 2
<211> 1665
<212> PRT
<213> Homo sapiens
<400> 2
Met Gly Cys Cys Arg Leu Gly Cys Gly Gly Cys Ser Val Ala His Ser
1               5                  10                  15      
Val Ser Gln Gly Leu Thr Asn His Pro Ser Met Val Gly Cys Gly Trp
20                  25                  30          
His Pro Gly Leu Cys Gly Trp Gly Gly Gly Leu His Ser Ser Leu Pro
35                  40                  45              
Ala Leu Pro Gly Pro Pro Ser Met Gln Val Thr Ile Glu Asp Val Gln
50                  55                  60                  
Ala Gln Thr Gly Gly Thr Ala Gln Phe Glu Ala Ile Ile Glu Gly Asp
65                  70                  75                  80  
Pro Gln Pro Ser Val Thr Trp Tyr Lys Asp Ser Val Gln Leu Val Asp
85                  90                  95      
Ser Thr Arg Leu Ser Gln Gln Gln Glu Gly Thr Thr Tyr Ser Leu Val
100                 105                 110         
Leu Arg His Val Ala Ser Lys Asp Ala Gly Val Tyr Thr Cys Leu Ala
115                 120                 125             
Gln Asn Thr Gly Gly Gln Val Leu Cys Lys Ala Glu Leu Leu Val Leu
130                 135                 140                 
Gly Gly Asp Asn Glu Pro Asp Ser Glu Lys Gln Ser His Arg Arg Lys
145                 150                 155                 160 
Leu His Ser Phe Tyr Glu Val Lys Glu Glu Ile Gly Arg Gly Val Phe
165                 170                 175     
Gly Phe Val Lys Arg Val Gln His Lys Gly Asn Lys Ile Leu Cys Ala
180                 185                 190         
Ala Lys Phe Ile Pro Leu Arg Ser Arg Thr Arg Ala Gln Ala Tyr Arg
195                 200                 205             
Glu Arg Asp Ile Leu Ala Ala Leu Ser His Pro Leu Val Thr Gly Leu
210                 215                 220                 
Leu Asp Gln Phe Glu Thr Arg Lys Thr Leu Ile Leu Ile Leu Glu Leu
225                 230                 235                 240 
Cys Ser Ser Glu Glu Leu Leu Asp Arg Leu Tyr Arg Lys Gly Val Val
245                 250                 255     
Thr Glu Ala Glu Val Lys Val Tyr Ile Gln Gln Leu Val Glu Gly Leu
260                 265                 270         
His Tyr Leu His Ser His Gly Val Leu His Leu Asp Ile Lys Pro Ser
275                 280                 285             
Asn Ile Leu Met Val His Pro Ala Arg Glu Asp Ile Lys Ile Cys Asp
290                 295                 300                 
Phe Gly Phe Ala Gln Asn Ile Thr Pro Ala Glu Leu Gln Phe Ser Gln
305                 310                 315                 320 
Tyr Gly Ser Pro Glu Phe Val Ser Pro Glu Ile Ile Gln Gln Asn Pro
325                 330                 335     
Val Ser Glu Ala Ser Asp Ile Trp Ala Met Gly Val Ile Ser Tyr Leu
340                 345                 350         
Ser Leu Thr Cys Ser Ser Pro Phe Ala Gly Glu Ser Asp Arg Ala Thr
355                 360                 365             
Leu Leu Asn Val Leu Glu Gly Arg Val Ser Trp Ser Ser Pro Met Ala
370                 375                 380                 
Ala His Leu Ser Glu Asp Ala Lys Asp Phe Ile Lys Ala Thr Leu Gln
385                 390                 395                 400 
Arg Ala Pro Gln Ala Arg Pro Ser Ala Ala Gln Cys Leu Ser His Pro
405                 410                 415     
Trp Phe Leu Lys Ser Met Pro Ala Glu Glu Ala His Phe Ile Asn Thr
420                 425                 430         
Lys Gln Leu Lys Phe Leu Leu Ala Arg Ser Arg Trp Gln Arg Ser Leu
435                 440                 445             
Met Ser Tyr Lys Ser Ile Leu Val Met Arg Ser Ile Pro Glu Leu Leu
450                 455                 460                 
Arg Gly Pro Pro Asp Ser Pro Ser Leu Gly Val Ala Arg His Leu Cys
465                 470                 475                 480 
Arg Asp Thr Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Asp Asn Glu
485                 490                 495     
Leu Ala Pro Phe Ala Arg Ala Lys Ser Leu Pro Pro Ser Pro Val Thr
500                 505                 510         
His Ser Pro Leu Leu His Pro Arg Gly Phe Leu Arg Pro Ser Ala Ser
515                 520                 525             
Leu Pro Glu Glu Ala Glu Ala Ser Glu Arg Ser Thr Glu Ala Pro Ala
530                 535                 540                 
Pro Pro Ala Ser Pro Glu Gly Ala Gly Pro Pro Ala Ala Gln Gly Cys
545                 550                 555                 560 
Val Pro Arg His Ser Val Ile Arg Ser Leu Phe Tyr His Gln Ala Gly
565                 570                 575     
Glu Ser Pro Glu His Gly Ala Leu Ala Pro Gly Ser Arg Arg His Pro
580                 585                 590         
Ala Arg Arg Arg His Leu Leu Lys Gly Gly Tyr Ile Ala Gly Ala Leu
595                 600                 605             
Pro Gly Leu Arg Glu Pro Leu Met Glu His Arg Val Leu Glu Glu Glu
610                 615                 620                 
Ala Ala Arg Glu Glu Gln Ala Thr Leu Leu Ala Lys Ala Pro Ser Phe
625                 630                 635                 640 
Glu Thr Ala Leu Arg Leu Pro Ala Ser Gly Thr His Leu Ala Pro Gly
645                 650                 655     
His Ser His Ser Leu Glu His Asp Ser Pro Ser Thr Pro Arg Pro Ser
660                 665                 670         
Ser Glu Ala Cys Gly Glu Ala Gln Arg Leu Pro Ser Ala Pro Ser Gly
675                 680                 685             
Gly Ala Pro Ile Arg Asp Met Gly His Pro Gln Gly Ser Lys Gln Leu
690                 695                 700                 
Pro Ser Thr Gly Gly His Pro Gly Thr Ala Gln Pro Glu Arg Pro Ser
705                 710                 715                 720 
Pro Asp Ser Pro Trp Gly Gln Pro Ala Pro Phe Cys His Pro Lys Gln
725                 730                 735     
Gly Ser Ala Pro Gln Glu Gly Cys Ser Pro His Pro Ala Val Ala Pro
740                 745                 750         
Cys Pro Pro Gly Ser Phe Pro Pro Gly Ser Cys Lys Glu Ala Pro Leu
755                 760                 765             
Val Pro Ser Ser Pro Phe Leu Gly Gln Pro Gln Ala Pro Pro Ala Pro
770                 775                 780                 
Ala Lys Ala Ser Pro Pro Leu Asp Ser Lys Met Gly Pro Gly Asp Ile
785                 790                 795                 800 
Ser Leu Pro Gly Arg Pro Lys Pro Gly Pro Cys Ser Ser Pro Gly Ser
805                 810                 815     
Ala Ser Gln Ala Ser Ser Ser Gln Val Ser Ser Leu Arg Val Gly Ser
820                 825                 830         
Ser Gln Val Gly Thr Glu Pro Gly Pro Ser Leu Asp Ala Glu Gly Trp
835                 840                 845             
Thr Gln Glu Ala Glu Asp Leu Ser Asp Ser Thr Pro Thr Leu Gln Arg
850                 855                 860                 
Pro Gln Glu Gln Val Thr Met Arg Lys Phe Ser Leu Gly Gly Arg Gly
865                 870                 875                 880 
Gly Tyr Ala Gly Val Ala Gly Tyr Gly Thr Phe Ala Phe Gly Gly Asp
885                 890                 895     
Ala Gly Gly Met Leu Gly Gln Gly Pro Met Trp Ala Arg Ile Ala Trp
900                 905                 910         
Ala Val Ser Gln Ser Glu Glu Glu Glu Gln Glu Glu Ala Arg Ala Glu
915                 920                 925             
Ser Gln Ser Glu Glu Gln Gln Glu Ala Arg Ala Glu Ser Pro Leu Pro
930                 935                 940                 
Gln Val Ser Ala Arg Pro Val Pro Glu Val Gly Arg Ala Pro Thr Arg
945                 950                 955                 960 
Ser Ser Pro Glu Pro Thr Pro Trp Glu Asp Ile Gly Gln Val Ser Leu
965                 970                 975     
Val Gln Ile Arg Asp Leu Ser Gly Asp Ala Glu Ala Ala Asp Thr Ile
980                 985                 990         
Ser Leu Asp Ile Ser Glu Val Asp Pro Ala Tyr Leu Asn Leu Ser Asp
995                 1000                1005            
Leu Tyr Asp Ile Lys Tyr Leu Pro Phe Glu Phe Met Ile Phe Arg Lys
1010                1015                1020                
Val Pro Lys Ser Ala Gln Pro Glu Pro Pro Ser Pro Met Ala Glu Glu
1025                1030                1035                1040
Glu Leu Ala Glu Phe Pro Glu Pro Thr Trp Pro Trp Pro Gly Glu Leu
1045                1050                1055    
Gly Pro His Ala Gly Leu Glu Ile Thr Glu Glu Ser Glu Asp Val Asp
1060                1065                1070        
Ala Leu Leu Ala Glu Ala Ala Val Gly Arg Lys Arg Lys Trp Ser Ser
1075                1080                1085            
Pro Ser Arg Ser Leu Phe His Phe Pro Gly Arg His Leu Pro Leu Asp
1090                1095                1100                
Glu Pro Ala Glu Leu Gly Leu Arg Glu Arg Val Lys Ala Ser Val Glu
1105                1110                1115                1120
His Ile Ser Arg Ile Leu Lys Gly Arg Pro Glu Gly Leu Glu Lys Glu
1125                1130                1135    
Gly Pro Pro Arg Lys Lys Pro Gly Leu Ala Ser Phe Arg Leu Ser Gly
1140                1145                1150        
Leu Lys Ser Trp Asp Arg Ala Pro Thr Phe Leu Arg Glu Leu Ser Asp
1155                1160                1165            
Glu Thr Val Val Leu Gly Gln Ser Val Thr Leu Ala Cys Gln Val Ser
1170                1175                1180                
Ala Gln Pro Ala Ala Gln Ala Thr Trp Ser Lys Asp Gly Ala Pro Leu
1185                1190                1195                1200
Glu Ser Ser Ser Arg Val Leu Ile Ser Ala Thr Leu Lys Asn Phe Gln
1205                1210                1215    
Leu Leu Thr Ile Leu Val Val Val Ala Glu Asp Leu Gly Val Tyr Thr
1220                1225                1230        
Cys Ser Val Ser Asn Ala Leu Gly Thr Val Thr Thr Thr Gly Val Leu
1235                1240                1245            
Arg Lys Ala Glu Arg Pro Ser Ser Ser Pro Cys Pro Asp Ile Gly Glu
1250                1255                1260                
Val Tyr Ala Asp Gly Val Leu Leu Val Trp Lys Pro Val Glu Ser Tyr
1265                1270                1275                1280
Gly Pro Val Thr Tyr Ile Val Gln Cys Ser Leu Glu Gly Gly Ser Trp
1285                1290                1295    
Thr Thr Leu Ala Ser Asp Ile Phe Asp Cys Cys Tyr Leu Thr Ser Lys
1300                1305                1310        
Leu Ser Arg Gly Gly Thr Tyr Thr Phe Arg Thr Ala Cys Val Ser Lys
1315                1320                1325            
Ala Gly Met Gly Pro Tyr Ser Ser Pro Ser Glu Gln Val Leu Leu Gly
1330                1335                1340                
Gly Pro Ser His Leu Ala Ser Glu Glu Glu Ser Gln Gly Arg Ser Ala
1345                1350                1355                1360
Gln Pro Leu Pro Ser Thr Lys Thr Phe Ala Phe Gln Thr Gln Ile Gln
1365                1370                1375    
Arg Gly Arg Phe Ser Val Val Arg Gln Cys Trp Glu Lys Ala Ser Gly
1380                1385                1390        
Arg Ala Leu Ala Ala Lys Ile Ile Pro Tyr His Pro Lys Asp Lys Thr
1395                1400                1405            
Ala Val Leu Arg Glu Tyr Glu Ala Leu Lys Gly Leu Arg His Pro His
1410                1415                1420                
Leu Ala Gln Leu His Ala Ala Tyr Leu Ser Pro Arg His Leu Val Leu
1425                1430                1435                1440
Ile Leu Glu Leu Cys Ser Gly Pro Glu Leu Leu Pro Cys Leu Ala Glu
1445                1450                1455    
Arg Ala Ser Tyr Ser Glu Ser Glu Val Lys Asp Tyr Leu Trp Gln Met
1460                1465                1470        
Leu Ser Ala Thr Gln Tyr Leu His Asn Gln His Ile Leu His Leu Asp
1475                1480                1485            
Leu Arg Ser Glu Asn Met Ile Ile Thr Glu Tyr Asn Leu Leu Lys Val
1490                1495                1500                
Val Asp Leu Gly Asn Ala Gln Ser Leu Ser Gln Glu Lys Val Leu Pro
1505                1510                1515                1520
Ser Asp Lys Phe Lys Asp Tyr Leu Glu Thr Met Ala Pro Glu Leu Leu
1525                1530                1535    
Glu Gly Gln Gly Ala Val Pro Gln Thr Asp Ile Trp Ala Ile Gly Val
1540                1545                1550        
Thr Ala Phe Ile Met Leu Ser Ala Glu Tyr Pro Val Ser Ser Glu Gly
1555                1560                1565            
Ala Arg Asp Leu Gln Arg Gly Leu Arg Lys Gly Leu Val Arg Leu Ser
1570                1575                1580                
Arg Cys Tyr Ala Gly Leu Ser Gly Gly Ala Val Ala Phe Leu Arg Ser
1585                1590                1595                1600
Thr Leu Cys Ala Gln Pro Trp Gly Arg Pro Cys Ala Ser Ser Cys Leu
1605                1610                1615    
Gln Cys Pro Trp Leu Thr Glu Glu Gly Pro Ala Cys Ser Arg Pro Ala
1620                1625                1630        
Pro Val Thr Phe Pro Thr Ala Arg Leu Arg Val Phe Val Arg Asn Arg
1635                1640                1645            
Glu Lys Arg Arg Ala Leu Leu Tyr Lys Arg His Asn Leu Ala Gln Val
1650                1655                1660                
Arg
1665
<210> 3
<211> 5207
<212> DNA
<213> Homo sapiens
<400> 3
cagcacgagg aactccttct gatcacctgg ccagctgagg tcagagtggg agaggcagtg 60
gttccattga aggagtactc ctaactgtca gaagcctggg cggtcaggat ggggtgctgt 120
cgcttgggct gcggggggtg ttcagttgcc cacagtgtat ctcagggtct caccaaccat 180
ccaagcatgg taggctgtgg ctggcaccca gggttgtgtg gctggggagg tggtctccac 240
agttccctcc ctgccctccc agggccccca tccatgcagg taaccatcga ggatgtgcag 300
gcacagacag gcggaacggc ccaattcgag gctatcattg agggcgaccc acagccctcg 360
gtgacctggt acaaggacag cgtccagctg gtggacagca cccggcttag ccagcagcaa 420
gaaggcacca catactccct ggtgctgagg catgtggcct cgaaggatgc cggcgtttac 480
acctgcctgg cccaaaacac tggtggccag gtgctctgca aggcagagct gctggtgctt 540
gggggggaca atgagccgga ctcagagaag caaagccacc ggaggaagct gcactccttc 600
tatgaggtca aggaggagat tggaaggggc gtgtttggct tcgtaaaaag agtgcagcac 660
aaaggaaaca agatcttgtg cgctgccaag ttcatccccc tacggagcag aactcgggcc 720
caggcataca gggagcgaga catcctggcc gcgctgagcc acccgctggt cacggggctg 780
ctggaccagt ttgagacccg caagaccctc atcctcatcc tggagctgtg ctcatccgag 840
gagctgctgg accgcctgta caggaagggc gtggtgacgg aggccgaggt caaggtctac 900
atccagcagc tggtggaggg gctgcactac ctgcacagcc atggcgttct ccacctggac 960
ataaagccct ctaacatcct gatggtgcat cctgcccggg aagacattaa aatctgcgac 1020
tttggctttg cccagaacat caccccagca gagctgcagt tcagccagta cggctcccct 1080
gagttcgtct cccccgagat catccagcag aaccctgtga gcgaagcctc cgacatttgg 1140
gccatgggtg tcatctccta cctcagcctg acctgctcat ccccatttgc cggcgagagt 1200
gaccgtgcca ccctcctgaa cgtcctggag gggcgcgtgt catggagcag ccccatggct 1260
gcccacctca gcgaagacgc caaagacttc atcaaggcta cgctgcagag agcccctcag 1320
gcccggccta gtgcggccca gtgcctctcc cacccctggt tcctgaaatc catgcctgcg 1380
gaggaggccc acttcatcaa caccaagcag ctcaagttcc tcctggcccg aagtcgctgg 1440
cagcgttccc tgatgagcta caagtccatc ctggtgatgc gctccatccc tgagctgctg 1500
cggggcccac ccgacagccc ctccctcggc gtagcccggc acctctgcag ggacactggt 1560
ggctcctcca gttcctcctc ctcctctgac aacgagctcg ccccatttgc ccgggctaag 1620
tcactgccac cctccccggt gacacactca ccactgctgc acccccgggg cttcctgcgg 1680
ccctcggcca gcctgcctga ggaagccgag gccagtgagc gctccaccga ggccccagct 1740
ccgcctgcat ctcccgaggg tgccgggcca ccggccgccc agggctgcgt gccccggcac 1800
agcgtcatcc gcagcctgtt ctaccaccag gcgggtgaga gccctgagca cggggccctg 1860
gccccgggga gcaggcggca cccggcccgg cggcggcacc tgctgaaggg cggctacatt 1920
gcgggggcgc tgccaggcct gcgcgagcca ctgatggagc accgcgtgct ggaggaggag 1980
gccgccaggg aggagcaggc caccctcctg gccaaagccc cctcattcga gactgccctc 2040
cggctgcctg cctctggcac ccacttggcc cctggccaca gccactccct ggaacatgac 2100
tctccgagca ccccccgccc ctcctcggag gcctgcggtg aggcacagcg actgccttca 2160
gccccctccg ggggggcccc tatcagggac atggggcacc ctcagggctc caagcagctt 2220
ccatccactg gtggccaccc aggcactgct cagccagaga ggccatcccc ggacagccct 2280
tgggggcagc cagccccttt ctgccacccc aagcagggtt ctgcccccca ggagggctgc 2340
agcccccacc cagcagttgc cccatgccct cctggctcct tccctccagg atcttgcaaa 2400
gaggccccct tagtaccctc aagccccttc ttgggacagc cccaggcacc ccctgcccct 2460
gccaaagcaa gccccccatt ggactctaag atggggcctg gagacatctc tcttcctggg 2520
aggccaaaac ccggcccctg cagttcccca gggtcagcct cccaggcgag ctcttcccaa 2580
gtgagctccc tcagggtggg ctcctcccag gtgggcacag agcctggccc ctccctggat 2640
gcggagggct ggacccagga ggctgaggat ctgtccgact ccacacccac cttgcagcgg 2700
cctcaggaac aggtgaccat gcgcaagttc tccctgggtg gtcgcggggg ctacgcaggc 2760
gtggctggct atggcacctt tgcctttggt ggagatgcag ggggcatgct ggggcagggg 2820
cccatgtggg ccaggatagc ctgggctgtg tcccagtcgg aggaggagga gcaggaggag 2880
gccagggctg agtcccagtc ggaggagcag caggaggcca gggctgagag cccactgccc 2940
caggtcagtg caaggcctgt gcctgaggtc ggcagggctc ccaccaggag ctctccagag 3000
cccaccccat gggaggacat cgggcaggtc tccctggtgc agatccggga cctgtcaggt 3060
gatgcggagg cggccgacac aatatccctg gacatttccg aggtggaccc cgcctacctc 3120
aacctctcag acctgtacga tatcaagtac ctcccattcg agtttatgat cttcaggaaa 3180
gtccccaagt ccgctcagcc agagccgccc tcccccatgg ctgaggagga gctggccgag 3240
ttcccggagc ccacgtggcc ctggccaggt gaactgggcc cccacgcagg cctggagatc 3300
acagaggagt cagaggatgt ggacgcgctg ctggcagagg ctgccgtggg caggaagcgc 3360
aagtggtcct cgccgtcacg cagcctcttc cacttccctg ggaggcacct gccgctggat 3420
gagcctgcag agctggggct gcgtgagaga gtgaaggcct ccgtggagca catctcccgg 3480
atcctgaagg gcaggccgga aggtctggag aaggaggggc cccccaggaa gaagccaggc 3540
cttgcttcct tccggctctc aggtctgaag agctgggacc gagcgccgac attcctaagg 3600
gagctctcag atgagactgt ggtcctgggc cagtcagtga cactggcctg ccaggtgtca 3660
gcccagccag ctgcccaggc cacctggagc aaagacggag cccccctgga gagcagcagc 3720
cgtgtcctca tctctgccac cctcaagaac ttccagcttc tgaccatcct ggtggtggtg 3780
gctgaggacc tgggtgtgta cacctgcagc gtgagcaatg cgctggggac agtgaccacc 3840
acgggcgtcc tccggaaggc agagcgcccc tcatcttcgc catgcccgga tatcggggag 3900
gtgtacgcgg atggggtgct gctggtctgg aagcccgtgg aatcctacgg ccctgtgacc 3960
tacattgtgc agtgcagcct agaaggcggc agctggacca cactggcctc cgacatcttt 4020
gactgctgct acctgaccag caagctctcc cggggtggca cctacacctt ccgcacggca 4080
tgtgtcagca aggcaggaat gggtccctac agcagcccct cggagcaagt cctcctggga 4140
gggcccagcc acctggcctc tgaggaggag agccaggggc ggtcagccca acccctgccc 4200
agcacaaaga ccttcgcatt ccagacacag atccagaggg gccgcttcag cgtggtgcgg 4260
caatgctggg agaaggccag cgggcgggcg ctggccgcca agatcatccc ctaccacccc 4320
aaggacaaga cagcagtgct gcgcgaatac gaggccctca agggcctgcg ccacccgcac 4380
ctggcccagc tgcacgcagc ctacctcagc ccccggcacc tggtgctcat cttggagctg 4440
tgctctgggc ccgagctgct cccctgcctg gccgagaggg cctcctactc agaatctgag 4500
gtgaaggact acctgtggca gatgttgagt gccacccagt acctgcacaa ccagcacatc 4560
ctgcacctgg acctgaggtc cgagaacatg atcatcaccg aatacaacct gctcaaggtc 4620
gtggacctgg gcaatgcaca gagcctcagc caggagaagg tgctgccctc agacaagttc 4680
aaggactacc tagagaccat ggctccagag ctcctggagg gccagggggc tgttccacag 4740
acagacatct gggccatcgg tgtgacagcc ttcatcatgc tgagcgccga gtacccggtg 4800
agcagcgagg gtgcacgcga cctgcagaga ggactgcgca aggggctggt ccggctgagc 4860
cgctgctacg cggggctgtc cgggggcgcc gtggccttcc tgcgcagcac tctgtgcgcc 4920
cagccctggg gccggccctg cgcgtccagc tgcctgcagt gcccgtggct aacagaggag 4980
ggcccggcct gttcgcggcc cgcgcccgtg accttcccta ccgcgcggct gcgcgtcttc 5040
gtgcgcaatc gcgagaagag acgcgcgctg ctgtacaaga ggcacaacct ggcccaggtg 5100
cgctgagggt cgccccggcc acacccttgg tctccccgct gggggtcgct gcagacgcgc 5160
caataaaaac gcacagccgg gcgagaaaaa aaaaaaaaaa aaaaaaa               5207
<210> 4
<211> 846
<212> PRT
<213> Homo sapiens
<400> 4
Pro Arg Phe Glu Ser Ile Met Glu Asp Val Glu Val Gly Ala Gly Glu
1               5                  10                  15      
Thr Ala Arg Phe Ala Val Val Val Glu Gly Lys Pro Leu Pro Asp Ile
20                  25                  30          
Met Trp Tyr Lys Asp Glu Val Leu Leu Thr Glu Ser Ser His Val Ser
35                  40                  45              
Phe Val Tyr Glu Glu Asn Glu Cys Ser Leu Val Val Leu Ser Thr Gly
50                  55                  60                  
Ala Gln Asp Gly Gly Val Tyr Thr Cys Thr Ala Gln Asn Leu Ala Gly
65                  70                  75                  80  
Glu Val Ser Cys Lys Ala Glu Leu Ala Val His Ser Ala Gln Thr Ala
85                  90                  95      
Met Glu Val Glu Gly Val Gly Glu Asp Glu Asp His Arg Gly Arg Arg
100                 105                 110         
Leu Ser Asp Phe Tyr Asp Ile His Gln Glu Ile Gly Arg Gly Ala Phe
115                 120                 125             
Ser Tyr Leu Arg Arg Ile Val Glu Arg Ser Ser Gly Leu Glu Phe Ala
130                 135                 140                 
Ala Lys Phe Ile Pro Ser Gln Ala Lys Pro Lys Ala Ser Ala Arg Arg
145                 150                 155                 160 
Glu Ala Arg Leu Leu Ala Arg Leu Gln His Asp Cys Val Leu Tyr Phe
165                 170                 175     
His Glu Ala Phe Glu Arg Arg Arg Gly Leu Val Ile Val Thr Glu Leu
180                 185                 190         
Cys Thr Glu Glu Leu Leu Glu Arg Ile Ala Arg Lys Pro Thr Val Cys
195                 200                 205             
Glu Ser Glu Ile Arg Ala Tyr Met Arg Gln Val Leu Glu Gly Ile His
210                 215                 220                 
Tyr Leu His Gln Ser His Val Leu His Leu Asp Val Lys Pro Glu Asn
225                 230                 235                 240 
Leu Leu Val Trp Asp Gly Ala Ala Gly Glu Gln Gln Val Arg Ile Cys
245                 250                 255     
Asp Phe Gly Asn Ala Gln Glu Leu Thr Pro Gly Glu Pro Gln Tyr Cys
260                 265                 270         
Gln Tyr Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Gln Ser
275                 280                 285             
Pro Val Ser Gly Val Thr Asp Ile Trp Pro Val Gly Val Val Ala Phe
290                 295                 300                 
Leu Cys Leu Thr Gly Ile Ser Pro Phe Val Gly Glu Asn Asp Arg Thr
305                 310                 315                 320 
Thr Leu Met Asn Ile Arg Asn Tyr Asn Val Ala Phe Glu Glu Thr Thr
325                 330                 335     
Phe Leu Ser Leu Ser Arg Glu Ala Arg Gly Phe Leu Ile Lys Val Leu
340                 345                 350         
Val Gln Asp Arg Leu Arg Pro Thr Ala Glu Glu Thr Leu Glu His Pro
355                 360                 365             
Trp Phe Lys Thr Gln Ala Lys Gly Ala Glu Val Ser Thr Asp His Leu
370                 375                 380                 
Lys Leu Phe Leu Ser Arg Arg Arg Trp Gln Arg Ser Gln Ile Ser Tyr
385                 390                 395                 400 
Lys Cys His Leu Val Leu Arg Pro Ile Pro Glu Leu Leu Arg Ala Pro
405                 410                 415     
Pro Glu Arg Val Trp Val Thr Met Pro Arg Arg Pro Pro Pro Ser Gly
420                 425                 430         
Gly Leu Ser Ser Ser Ser Asp Ser Glu Glu Glu Glu Leu Glu Glu Leu
435                 440                 445             
Pro Ser Val Pro Arg Pro Leu Gln Pro Glu Phe Ser Gly Ser Arg Val
450                 455                 460                 
Ser Leu Thr Asp Ile Pro Thr Glu Asp Glu Ala Leu Gly Thr Pro Glu
465                 470                 475                 480 
Thr Gly Ala Ala Thr Pro Met Asp Trp Gln Glu Gln Gly Arg Ala Pro
485                 490                 495     
Ser Gln Asp Gln Glu Ala Pro Ser Pro Glu Ala Leu Pro Ser Pro Gly
500                 505                 510         
Gln Glu Pro Ala Ala Gly Ala Ser Pro Arg Arg Gly Glu Leu Arg Arg
515                 520                 525             
Gly Ser Ser Ala Glu Ser Ala Leu Pro Arg Ala Gly Pro Arg Glu Leu
530                 535                 540                 
Gly Arg Gly Leu His Lys Ala Ala Ser Val Glu Leu Pro Gln Arg Arg
545                 550                 555                 560 
Ser Pro Gly Pro Gly Ala Thr Arg Leu Ala Arg Gly Gly Leu Gly Glu
565                 570                 575     
Gly Glu Tyr Ala Gln Arg Leu Gln Ala Leu Arg Gln Arg Leu Leu Arg
580                 585                 590         
Gly Gly Pro Glu Asp Gly Lys Val Ser Gly Leu Arg Gly Pro Leu Leu
595                 600                 605             
Glu Ser Leu Gly Gly Arg Ala Arg Asp Pro Arg Met Ala Arg Ala Ala
610                 615                 620                 
Ser Ser Glu Ala Ala Pro His His Gln Pro Pro Leu Glu Asn Arg Gly
625                 630                 635                 640 
Leu Gln Lys Ser Ser Ser Phe Ser Gln Gly Glu Ala Glu Pro Arg Gly
645                 650                 655     
Arg His Arg Arg Ala Gly Ala Pro Leu Glu Ile Pro Val Ala Arg Leu
660                 665                 670         
Gly Ala Arg Arg Leu Gln Glu Ser Pro Ser Leu Ser Ala Leu Ser Glu
675                 680                 685             
Ala Gln Pro Ser Ser Pro Ala Arg Pro Ser Ala Pro Lys Pro Ser Thr
690                 695                 700                 
Pro Lys Ser Ala Glu Pro Ser Ala Thr Thr Pro Ser Asp Ala Pro Gln
705                 710                 715                 720 
Pro Pro Ala Pro Gln Pro Ala Gln Asp Lys Ala Pro Glu Pro Arg Pro
725                 730                 735     
Glu Pro Val Arg Ala Ser Lys Pro Ala Pro Pro Pro Gln Ala Leu Gln
740                 745                 750         
Thr Leu Ala Leu Pro Leu Thr Pro Tyr Ala Gln Ile Ile Gln Ser Leu
755                 760                 765             
Gln Leu Ser Gly His Ala Gln Gly Pro Ser Gln Gly Pro Ala Ala Pro
770                 775                 780                 
Pro Ser Glu Pro Lys Pro His Ala Ala Val Phe Ala Arg Val Ala Ser
785                 790                 795                 800 
Pro Pro Pro Gly Ala Pro Glu Lys Arg Val Pro Ser Ala Gly Gly Pro
805                 810                 815     
Pro Val Leu Ala Glu Lys Ala Arg Val Pro Thr Val Pro Pro Arg Pro
820                 825                 830         
Gly Ser Ser Leu Ser Ser Ser Ile Glu Asn Leu Glu Ser Glu
835                 840                 845     
<210> 5
<211> 279
<212> PRT
<213> Homo sapiens
<400> 5
Ser Pro Ala Lys Glu Val Val Ser Ser Pro Gly Ser Ser Pro Arg Ser
1               5                  10                  15      
Ser Pro Arg Pro Glu Gly Thr Thr Leu Arg Gln Gly Pro Pro Gln Lys
20                  25                  30          
Pro Tyr Thr Phe Leu Glu Glu Lys Ala Arg Gly Arg Phe Gly Val Val
35                  40                  45              
Arg Ala Cys Arg Glu Asn Ala Thr Gly Arg Thr Phe Val Ala Lys Ile
50                  55                  60                  
Val Pro Tyr Ala Ala Glu Gly Lys Pro Arg Val Leu Gln Glu Tyr Glu
65                  70                  75                  80  
Val Leu Arg Thr Leu His His Glu Arg Ile Met Ser Leu His Glu Ala
85                  90                  95      
Tyr Ile Thr Pro Arg Tyr Leu Val Leu Ile Ala Glu Ser Cys Gly Asn
100                 105                 110         
Arg Glu Leu Leu Cys Gly Leu Ser Asp Arg Phe Arg Tyr Ser Glu Asp
115                 120                 125             
Asp Val Ala Thr Tyr Met Val Gln Leu Leu Gln Gly Leu Asp Tyr Leu
130                 135                 140                 
His Gly His His Val Leu His Leu Asp Ile Lys Pro Asp Asn Leu Leu
145                 150                 155                 160 
Leu Ala Pro Asp Asn Ala Leu Lys Ile Val Asp Phe Gly Ser Ala Gln
165                 170                 175     
Pro Tyr Asn Pro Gln Ala Leu Arg Pro Leu Gly His Arg Thr Gly Thr
180                 185                 190         
Leu Glu Phe Met Ala Pro Glu Met Val Lys Gly Glu Pro Ile Gly Ser
195                 200                 205             
Ala Thr Asp Ile Trp Gly Ala Gly Val Leu Thr Tyr Ile Met Leu Ser
210                 215                 220                 
Gly Arg Ser Pro Phe Tyr Glu Pro Asp Pro Gln Glu Thr Glu Ala Arg
225                 230                 235                 240 
Ile Val Gly Gly Arg Phe Asp Ala Phe Gln Leu Tyr Pro Asn Thr Ser
245                 250                 255     
Gln Ser Ala Thr Leu Phe Leu Arg Lys Val Leu Ser Val His Pro Trp
260                 265                 270         
Ser Arg Pro Ser Ser Cys Leu
275                 
<210> 6
<211> 549
<212> PRT
<213> Homo sapiens
<400> 6
Leu Arg Glu Pro Gly Trp Ala Ala Thr Gly Leu Arg Lys Gly Val Gln
1               5                  10                  15      
His Ile Phe Arg Val Leu Ser Thr Thr Val Lys Ser Ser Ser Lys Pro
20                  25                  30          
Ser Pro Pro Ser Glu Pro Val Gln Leu Leu Glu His Gly Pro Thr Leu
35                  40                  45              
Glu Glu Ala Pro Ala Met Leu Asp Lys Pro Asp Ile Val Tyr Val Val
50                  55                  60                  
Glu Gly Gln Pro Ala Ser Val Thr Val Thr Phe Asn His Val Glu Ala
65                  70                  75                  80  
Gln Val Val Trp Arg Ser Cys Arg Gly Ala Leu Leu Glu Ala Arg Ala
85                  90                  95      
Gly Val Tyr Glu Leu Ser Gln Pro Asp Asp Asp Gln Tyr Cys Leu Arg
100                 105                 110         
Ile Cys Arg Val Ser Arg Arg Asp Met Gly Ala Leu Thr Cys Thr Ala
115                 120                 125             
Arg Asn Arg His Gly Thr Gln Thr Cys Ser Val Thr Leu Glu Leu Ala
130                 135                 140                 
Glu Ala Pro Arg Phe Glu Ser Ile Met Glu Asp Val Glu Val Gly Ala
145                 150                 155                 160 
Gly Glu Thr Ala Arg Phe Ala Val Val Val Glu Gly Lys Pro Leu Pro
165                 170                 175     
Asp Ile Met Trp Tyr Lys Asp Glu Val Leu Leu Thr Glu Ser Ser His
180                 185                 190         
Val Ser Phe Val Tyr Glu Glu Asn Glu Cys Ser Leu Val Val Leu Ser
195                 200                 205             
Thr Gly Ala Gln Asp Gly Gly Val Tyr Thr Cys Thr Ala Gln Asn Leu
210                 215                 220                 
Ala Gly Glu Val Ser Cys Lys Ala Glu Leu Ala Val His Ser Ala Gln
225                 230                 235                 240 
Thr Ala Met Glu Val Glu Gly Val Gly Glu Asp Glu Asp His Arg Gly
245                 250                 255     
Arg Arg Leu Ser Asp Phe Tyr Asp Ile His Gln Glu Ile Gly Arg Gly
260                 265                 270         
Ala Phe Ser Tyr Leu Arg Arg Ile Val Glu Arg Ser Ser Gly Leu Glu
275                 280                 285             
Phe Ala Ala Lys Phe Ile Pro Ser Gln Ala Lys Pro Lys Ala Ser Ala
290                 295                 300                 
Arg Arg Glu Ala Arg Leu Leu Ala Arg Leu Gln His Asp Cys Val Leu
305                 310                 315                 320 
Tyr Phe His Glu Ala Phe Glu Arg Arg Arg Gly Leu Val Ile Val Thr
325                 330                 335     
Glu Leu Cys Thr Glu Glu Leu Leu Glu Arg Ile Ala Arg Lys Pro Thr
340                 345                 350         
Val Cys Glu Ser Glu Ile Arg Ala Tyr Met Arg Gln Val Leu Glu Gly
355                 360                 365             
Ile His Tyr Leu His Gln Ser His Val Leu His Leu Asp Val Lys Pro
370                 375                 380                 
Glu Asn Leu Leu Val Trp Asp Gly Ala Ala Gly Glu Gln Gln Val Arg
385                 390                 395                 400 
Ile Cys Asp Phe Gly Asn Ala Gln Glu Leu Thr Pro Gly Glu Pro Gln
405                 410                 415     
Tyr Cys Gln Tyr Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn
420                 425                 430         
Gln Ser Pro Val Ser Gly Val Thr Asp Ile Trp Pro Val Gly Val Val
435                 440                 445             
Ala Phe Leu Cys Leu Thr Gly Ile Ser Pro Phe Val Gly Glu Asn Asp
450                 455                 460                 
Arg Thr Thr Leu Met Asn Ile Arg Asn Tyr Asn Val Ala Phe Glu Glu
465                 470                 475                 480 
Thr Thr Phe Leu Ser Leu Ser Arg Glu Ala Arg Gly Phe Leu Ile Lys
485                 490                 495     
Val Leu Val Gln Asp Arg Leu Arg Pro Thr Ala Glu Glu Thr Leu Glu
500                 505                 510         
His Pro Trp Phe Lys Thr Gln Ala Lys Gly Ala Glu Val Ser Thr Asp
515                 520                 525             
His Leu Lys Leu Phe Leu Ser Arg Arg Arg Trp Gln Arg Ser Gln Ile
530                 535                 540                 
Ser Tyr Lys Cys His
545                 
<210> 7
<211> 250
<212> PRT
<213> Homo sapiens
<400> 7
Tyr Thr Phe Leu Glu Glu Lys Ala Arg Gly Arg Phe Gly Val Val Arg
1               5                  10                  15      
Ala Cys Arg Glu Asn Ala Thr Gly Arg Thr Phe Val Ala Lys Ile Val
20                  25                  30          
Pro Tyr Ala Ala Glu Gly Lys Pro Arg Val Leu Gln Glu Tyr Glu Val
35                  40                  45              
Leu Arg Thr Leu His His Glu Arg Ile Met Ser Leu His Glu Ala Tyr
50                  55                  60                  
Ile Thr Pro Arg Tyr Leu Val Leu Ile Ala Glu Ser Cys Gly Asn Arg
65                  70                  75                  80  
Glu Leu Leu Cys Gly Leu Ser Asp Arg Phe Arg Tyr Ser Glu Asp Asp
85                  90                  95      
Val Ala Thr Tyr Met Val Gln Leu Leu Gln Gly Leu Asp Tyr Leu His
100                 105                 110         
Gly His His Val Leu His Leu Asp Ile Lys Pro Asp Asn Leu Leu Leu
115                 120                 125             
Ala Pro Asp Asn Ala Leu Lys Ile Val Asp Phe Gly Ser Ala Gln Pro
130                 135                 140                 
Tyr Asn Pro Gln Ala Leu Arg Pro Leu Gly His Arg Thr Gly Thr Leu
145                 150                 155                 160 
Glu Phe Met Ala Pro Glu Met Val Lys Gly Glu Pro Ile Gly Ser Ala
165                 170                 175     
Thr Asp Ile Trp Gly Ala Gly Val Leu Thr Tyr Ile Met Leu Ser Gly
180                 185                 190         
Arg Ser Pro Phe Tyr Glu Pro Asp Pro Gln Glu Thr Glu Ala Arg Ile
195                 200                 205             
Val Gly Gly Arg Phe Asp Ala Phe Gln Leu Tyr Pro Asn Thr Ser Gln
210                 215                 220                 
Ser Ala Thr Leu Phe Leu Arg Lys Val Leu Ser Val His Pro Trp Ser
225                 230                 235                 240 
Arg Pro Ser Ser Cys Leu Ser Val Cys His
245                 250 
<210> 8
<211> 245
<212> PRT
<213> Homo sapiens
<400> 8
Pro Arg Lys Asp Lys Gly Leu Ser Pro Pro Asn Leu Ser Ala Ser Val
1               5                  10                  15      
Gln Glu Glu Leu Gly His Gln Tyr Val Arg Ser Glu Ser Asp Phe Pro
20                  25                  30          
Pro Val Phe His Ile Lys Leu Lys Asp Gln Val Leu Leu Glu Gly Glu
35                  40                  45              
Ala Ala Thr Leu Leu Cys Leu Pro Ala Ala Cys Pro Ala Pro His Ile
50                  55                  60                  
Ser Trp Met Lys Asp Lys Lys Ser Leu Arg Ser Glu Pro Ser Val Ile
65                  70                  75                  80  
Ile Val Ser Cys Lys Asp Gly Arg Gln Leu Leu Ser Ile Pro Arg Ala
85                  90                  95      
Gly Lys Arg His Ala Gly Leu Tyr Glu Cys Ser Ala Thr Asn Val Leu
100                 105                 110         
Gly Ser Ile Thr Ser Ser Cys Thr Val Ala Val Ala Arg Val Pro Gly
115                 120                 125             
Lys Leu Ala Pro Pro Glu Val Thr Gln Thr Tyr Gln Asp Thr Ala Leu
130                 135                 140                 
Val Leu Trp Lys Pro Gly Asp Ser Arg Ala Pro Cys Thr Tyr Thr Leu
145                 150                 155                 160 
Glu Arg Arg Val Asp Gly Glu Ser Val Trp His Pro Val Ser Ser Gly
165                 170                 175     
Ile Pro Asp Cys Tyr Tyr Asn Val Thr His Leu Pro Val Gly Val Thr
180                 185                 190         
Val Arg Phe Arg Val Ala Cys Ala Asn Arg Ala Gly Gln Gly Pro Phe
195                 200                 205             
Ser Asn Ser Ser Glu Lys Val Phe Val Arg Gly Thr Gln Asp Ser Ser
210                 215                 220                 
Ala Val Pro Ser Ala Ala His Gln Glu Ala Pro Val Thr Ser Arg Pro
225                 230                 235                 240 
Ala Arg Ala Arg Pro
245 
<210> 9
<211> 111
<212> PRT
<213> Homo sapiens
<400> 9
Leu Glu Asp Val Glu Val Leu Glu Gly Arg Ala Ala Arg Phe Asp Cys
1               5                  10                  15      
Lys Ile Ser Gly Thr Pro Pro Pro Val Val Thr Trp Thr His Phe Gly
20                  25                  30          
Cys Pro Met Glu Glu Ser Glu Asn Leu Arg Leu Arg Gln Asp Gly Gly
35                  40                  45              
Leu His Ser Leu His Ile Ala His Val Gly Ser Glu Asp Glu Gly Leu
50                  55                  60                  
Tyr Ala Val Ser Ala Val Asn Thr His Gly Gln Ala His Cys Ser Ala
65                  70                  75                  80  
Gln Leu Tyr Val Glu Glu Pro Arg Thr Ala Ala Ser Gly Pro Ser Ser
85                  90                  95      
Lys Leu Glu Lys Met Pro Ser Ile Pro Glu Glu Pro Glu Gln Gly
100                 105                 110     
<210> 10
<211> 198
<212> PRT
<213> Homo sapiens
<400> 10
Pro Asp Phe Leu Arg Pro Leu Gln Asp Leu Glu Val Gly Leu Ala Lys
1               5                  10                  15      
Glu Ala Met Leu Glu Cys Gln Val Thr Gly Leu Pro Tyr Pro Thr Ile
20                  25                  30          
Ser Trp Phe His Asn Gly His Arg Ile Gln Ser Ser Asp Asp Arg Arg
35                  40                  45              
Met Thr Gln Tyr Arg Asp Val His Arg Leu Val Phe Pro Ala Val Gly
50                  55                  60                  
Pro Gln His Ala Gly Val Tyr Lys Ser Val Ile Ala Asn Lys Leu Gly
65                  70                  75                  80  
Lys Ala Ala Cys Tyr Ala His Leu Tyr Val Thr Asp Val Val Pro Gly
85                  90                  95      
Pro Pro Asp Gly Ala Pro Gln Val Val Ala Val Thr Gly Arg Met Val
100                 105                 110         
Thr Leu Thr Trp Asn Pro Pro Arg Ser Leu Asp Met Ala Ile Asp Pro
115                 120                 125             
Asp Ser Leu Thr Tyr Thr Val Gln His Gln Val Leu Gly Ser Asp Gln
130                 135                 140                 
Trp Thr Ala Leu Val Thr Gly Leu Arg Glu Pro Gly Trp Ala Ala Thr
145                 150                 155                 160 
Gly Leu Arg Lys Gly Val Gln His Ile Phe Arg Val Leu Ser Thr Thr
165                 170                 175     
Val Lys Ser Ser Ser Lys Pro Ser Pro Pro Ser Glu Pro Val Gln Leu
180                 185                 190         
Leu Glu His Gly Pro Thr
195             
<210> 11
<211> 101
<212> PRT
<213> Homo sapiens
<400> 11
Ala Pro Leu Phe Thr Arg Leu Leu Glu Asp Val Glu Val Leu Glu Gly
1               5                  10                  15      
Arg Ala Ala Arg Phe Asp Cys Lys Ile Ser Gly Thr Pro Pro Pro Val
20                  25                  30          
Val Thr Trp Thr His Phe Gly Cys Pro Met Glu Glu Ser Glu Asn Leu
35                  40                  45              
Arg Leu Arg Gln Asp Gly Gly Leu His Ser Leu His Ile Ala His Val
50                  55                  60                  
Gly Ser Glu Asp Glu Gly Leu Tyr Ala Val Ser Ala Val Asn Thr His
65                  70                  75                  80  
Gly Gln Ala His Cys Ser Ala Gln Leu Tyr Val Glu Glu Pro Arg Thr
85                  90                  95      
Ala Ala Ser Gly Pro
100     
<210> 12
<211> 195
<212> PRT
<213> Homo sapiens
<400> 12
Arg Gly Thr Gln Asp Ser Ser Ala Val Pro Ser Ala Ala His Gln Glu
1               5                  10                  15      
Ala Pro Val Thr Ser Arg Pro Ala Arg Ala Arg Pro Pro Asp Ser Pro
20                  25                  30          
Thr Ser Leu Ala Pro Pro Leu Ala Pro Ala Ala Pro Thr Pro Pro Ser
35                  40                  45              
Val Thr Val Ser Pro Ser Ser Pro Pro Thr Pro Pro Ser Gln Ala Leu
50                  55                  60                  
Ser Ser Leu Lys Ala Val Gly Pro Pro Pro Gln Thr Pro Pro Arg Arg
65                  70                  75                  80  
His Arg Gly Leu Gln Ala Ala Arg Pro Ala Glu Pro Thr Leu Pro Ser
85                  90                  95      
Thr His Val Thr Pro Ser Glu Pro Lys Pro Phe Val Leu Asp Thr Gly
100                 105                 110         
Thr Pro Ile Pro Ala Ser Thr Pro Gln Gly Val Lys Pro Val Ser Ser
115                 120                 125             
Ser Thr Pro Val Tyr Val Val Thr Ser Phe Val Ser Ala Pro Pro Ala
130                 135                 140                 
Pro Glu Pro Pro Ala Pro Glu Pro Pro Pro Glu Pro Thr Lys Val Thr
145                 150                 155                 160 
Val Gln Ser Leu Ser Pro Ala Lys Glu Val Val Ser Ser Pro Gly Ser
165                 170                 175     
Ser Pro Arg Ser Ser Pro Arg Pro Glu Gly Thr Thr Leu Arg Gln Gly
180                 185                 190         
Pro Pro Gln
195 
<210> 13
<211> 90
<212> PRT
<213> Homo sapiens
<400> 13
Pro Asp Phe Leu Arg Pro Leu Gln Asp Leu Glu Val Gly Leu Ala Lys
1               5                  10                  15      
Glu Ala Met Leu Glu Cys Gln Val Thr Gly Leu Pro Tyr Pro Thr Ile
20                  25                  30          
Ser Trp Phe His Asn Gly His Arg Ile Gln Ser Ser Asp Asp Arg Arg
35                  40                  45              
Met Thr Gln Tyr Arg Asp Val His Arg Leu Val Phe Pro Ala Val Gly
50                  55                  60                  
Pro Gln His Ala Gly Val Tyr Lys Ser Val Ile Ala Asn Lys Leu Gly
65                  70                  75                  80  
Lys Ala Ala Cys Tyr Ala His Leu Tyr Val
85                  90  
<210> 14
<211> 414
<212> PRT
<213> Homo sapiens
<400> 14
Pro Pro Glu Phe Val Ile Pro Leu Ser Glu Val Thr Cys Glu Thr Gly
1               5                  10                  15      
Glu Thr Val Val Leu Arg Cys Arg Val Cys Gly Arg Pro Lys Ala Ser
20                  25                  30          
Ile Thr Trp Lys Gly Pro Glu His Asn Thr Leu Asn Asn Asp Gly His
35                  40                  45              
Tyr Ser Ile Ser Tyr Ser Asp Leu Gly Glu Ala Thr Leu Lys Ile Val
50                  55                  60                  
Gly Val Thr Thr Glu Asp Asp Gly Ile Tyr Thr Cys Ile Ala Val Asn
65                  70                  75                  80  
Asp Met Gly Ser Ala Ser Ser Ser Ala Ser Leu Arg Val Leu Gly Pro
85                  90                  95      
Gly Met Asp Gly Ile Met Val Thr Trp Lys Asp Asn Phe Asp Ser Phe
100                 105                 110         
Tyr Ser Glu Val Ala Glu Leu Gly Arg Gly Arg Phe Ser Val Val Lys
115                 120                 125             
Lys Cys Asp Gln Lys Gly Thr Lys Arg Ala Val Ala Thr Lys Phe Val
130                 135                 140                 
Asn Lys Lys Leu Met Lys Arg Asp Gln Val Thr His Glu Leu Gly Ile
145                 150                 155                 160 
Leu Gln Ser Leu Gln His Pro Leu Leu Val Gly Leu Leu Asp Thr Phe
165                 170                 175     
Glu Thr Pro Thr Ser Tyr Ile Leu Val Leu Glu Met Ala Asp Gln Gly
180                 185                 190         
Arg Leu Leu Asp Cys Val Val Arg Trp Gly Ser Leu Thr Glu Gly Lys
195                 200                 205             
Ile Arg Ala His Leu Gly Glu Val Leu Glu Ala Val Arg Tyr Leu His
210                 215                 220                 
Asn Cys Arg Ile Ala His Leu Asp Leu Lys Pro Glu Asn Ile Leu Val
225                 230                 235                 240 
Asp Glu Ser Leu Ala Lys Pro Thr Ile Lys Leu Ala Asp Phe Gly Asp
245                 250                 255     
Ala Val Gln Leu Asn Thr Thr Tyr Tyr Ile His Gln Leu Leu Gly Asn
260                 265                 270         
Pro Glu Phe Ala Ala Pro Glu Ile Ile Leu Gly Asn Pro Val Ser Leu
275                 280                 285             
Thr Ser Asp Thr Trp Ser Val Gly Val Leu Thr Tyr Val Leu Leu Ser
290                 295                 300                 
Gly Val Ser Pro Phe Leu Asp Asp Ser Val Glu Glu Thr Cys Leu Asn
305                 310                 315                 320 
Ile Cys Arg Leu Asp Phe Ser Phe Pro Asp Asp Tyr Phe Lys Gly Val
325                 330                 335     
Ser Gln Lys Ala Lys Glu Phe Val Cys Phe Leu Leu Gln Glu Asp Pro
340                 345                 350         
Ala Lys Arg Pro Ser Ala Ala Leu Ala Leu Gln Glu Gln Trp Leu Gln
355                 360                 365             
Ala Gly Asn Gly Arg Ser Thr Gly Val Leu Asp Thr Ser Arg Leu Thr
370                 375                 380                 
Ser Phe Ile Glu Arg Arg Lys His Gln Asn Asp Val Arg Pro Ile Arg
385                 390                 395                 400 
Ser Ile Lys Asn Phe Leu Gln Ser Arg Leu Leu Pro Arg Val
405                 410                 
<210> 15
<211> 274
<212> PRT
<213> Homo sapiens
<400> 15
Glu Leu Gly Arg Gly Arg Phe Ser Val Val Lys Lys Cys Asp Gln Lys
1               5                  10                  15      
Gly Thr Lys Arg Ala Val Ala Thr Lys Phe Val Asn Lys Lys Leu Met
20                  25                  30          
Lys Arg Asp Gln Val Thr His Glu Leu Gly Ile Leu Gln Ser Leu Gln
35                  40                  45              
His Pro Leu Leu Val Gly Leu Leu Asp Thr Phe Glu Thr Pro Thr Ser
50                  55                  60                  
Tyr Ile Leu Val Leu Glu Met Ala Asp Gln Gly Arg Leu Leu Asp Cys
65                  70                  75                  80  
Val Val Arg Trp Gly Ser Leu Thr Glu Gly Lys Ile Arg Ala His Leu
85                  90                  95      
Gly Glu Val Leu Glu Ala Val Arg Tyr Leu His Asn Cys Arg Ile Ala
100                 105                 110         
His Leu Asp Leu Lys Pro Glu Asn Ile Leu Val Asp Glu Ser Leu Ala
115                 120                 125             
Lys Pro Thr Ile Lys Leu Ala Asp Phe Gly Asp Ala Val Gln Leu Asn
130                 135                 140                 
Thr Thr Tyr Tyr Ile His Gln Leu Leu Gly Asn Pro Glu Phe Ala Ala
145                 150                 155                 160 
Pro Glu Ile Ile Leu Gly Asn Pro Val Ser Leu Thr Ser Asp Thr Trp
165                 170                 175     
Ser Val Gly Val Leu Thr Tyr Val Leu Leu Ser Gly Val Ser Pro Phe
180                 185                 190         
Leu Asp Asp Ser Val Glu Glu Thr Cys Leu Asn Ile Cys Arg Leu Asp
195                 200                 205             
Phe Ser Phe Pro Asp Asp Tyr Phe Lys Gly Val Ser Gln Lys Ala Lys
210                 215                 220                 
Glu Phe Val Cys Phe Leu Leu Gln Glu Asp Pro Ala Lys Arg Pro Ser
225                 230                 235                 240 
Ala Ala Leu Ala Leu Gln Glu Gln Trp Leu Gln Ala Gly Asn Gly Arg
245                 250                 255     
Ser Thr Gly Val Leu Asp Thr Ser Arg Leu Thr Ser Phe Ile Glu Arg
260                 265                 270         
Arg Lys
<210> 16
<211> 141
<212> PRT
<213> Homo sapiens
<400> 16
Gly Lys Arg Glu Gly Lys Leu Glu Asn Gly Tyr Arg Lys Ser Arg Glu
1               5                  10                  15      
Gly Leu Ser Asn Lys Val Ser Val Lys Leu Leu Asn Pro Asn Tyr Ile
20                  25                  30          
Tyr Asp Val Pro Pro Glu Phe Val Ile Pro Leu Ser Glu Val Thr Cys
35                  40                  45              
Glu Thr Gly Glu Thr Val Val Leu Arg Cys Arg Val Cys Gly Arg Pro
50                  55                  60                  
Lys Ala Ser Ile Thr Trp Lys Gly Pro Glu His Asn Thr Leu Asn Asn
65                  70                  75                  80  
Asp Gly His Tyr Ser Ile Ser Tyr Ser Asp Leu Gly Glu Ala Thr Leu
85                  90                  95      
Lys Ile Val Gly Val Thr Thr Glu Asp Asp Gly Ile Tyr Thr Cys Ile
100                 105                 110         
Ala Val Asn Asp Met Gly Ser Ala Ser Ser Ser Ala Ser Leu Arg Val
115                 120                 125             
Leu Gly Pro Gly Met Asp Gly Ile Met Val Thr Trp Lys
130                 135                 140     
<210> 17
<211> 196
<212> PRT
<213> Homo sapiens
<400> 17
Gly Gly Ala Pro Ser Gly Gly Ser Gly His Ser Gly Gly Pro Ser Ser
1               5                  10                  15      
Cys Gly Gly Ala Pro Ser Thr Ser Arg Ser Arg Pro Ser Arg Ile Pro
20                  25                  30          
Gln Pro Val Arg His His Pro Pro Val Leu Val Ser Ser Ala Ala Ser
35                  40                  45              
Ser Gln Ala Glu Ala Asp Lys Met Ser Gly Thr Ser Thr Pro Gly Pro
50                  55                  60                  
Ser Leu Pro Pro Pro Gly Ala Ala Pro Glu Ala Gly Pro Ser Ala Pro
65                  70                  75                  80  
Ser Arg Arg Pro Pro Gly Ala Asp Ala Glu Gly Ser Glu Arg Glu Ala
85                  90                  95      
Glu Pro Ile Pro Lys Met Lys Val Leu Glu Ser Pro Arg Lys Gly Ala
100                 105                 110         
Ala Asn Ala Ser Gly Ser Ser Pro Asp Ala Pro Ala Lys Asp Ala Arg
115                 120                 125             
Ala Ser Leu Gly Thr Leu Pro Leu Gly Lys Pro Arg Ala Gly Ala Ala
130                 135                 140                 
Ser Pro Leu Asn Ser Pro Leu Ser Ser Ala Val Pro Ser Leu Gly Lys
145                 150                 155                 160 
Glu Pro Phe Pro Pro Ser Ser Pro Leu Gln Lys Gly Gly Ser Phe Trp
165                 170                 175     
Ser Ser Ile Pro Ala Ser Pro Ala Ser Arg Pro Gly Ser Phe Thr Phe
180                 185                 190         
Pro Gly Asp Ser
195     
<210> 18
<211> 298
<212> PRT
<213> Homo sapiens
<400> 18
Gln Lys Val Ser Asp Phe Tyr Asp Ile Glu Glu Arg Leu Gly Ser Gly
1               5                  10                  15      
Lys Phe Gly Gln Val Phe Arg Leu Val Glu Lys Lys Thr Arg Lys Val
20                  25                  30          
Trp Ala Gly Lys Phe Phe Lys Ala Tyr Ser Ala Lys Glu Lys Glu Asn
35                  40                  45              
Ile Arg Gln Glu Ile Ser Ile Met Asn Cys Leu His His Pro Lys Leu
50                  55                  60                  
Val Gln Cys Val Asp Ala Phe Glu Glu Lys Ala Asn Ile Val Met Val
65                  70                  75                  80  
Leu Glu Ile Val Ser Gly Gly Glu Leu Phe Glu Arg Ile Ile Asp Glu
85                  90                  95      
Asp Phe Glu Leu Thr Glu Arg Glu Cys Ile Lys Tyr Met Arg Gln Ile
100                 105                 110         
Ser Glu Gly Val Glu Tyr Ile His Lys Gln Gly Ile Val His Leu Asp
115                 120                 125             
Leu Lys Pro Glu Asn Ile Met Cys Val Asn Lys Thr Gly Thr Arg Ile
130                 135                 140                 
Lys Leu Ile Asp Phe Gly Leu Ala Arg Arg Leu Glu Asn Ala Gly Ser
145                 150                 155                 160 
Leu Lys Val Leu Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Val Ile
165                 170                 175     
Asn Tyr Glu Pro Ile Ser Tyr Ala Thr Asp Met Trp Ser Ile Gly Val
180                 185                 190         
Ile Cys Tyr Ile Leu Val Ser Gly Leu Ser Pro Phe Met Gly Asp Asn
195                 200                 205             
Asp Asn Glu Thr Leu Ala Asn Val Thr Ser Ala Thr Trp Asp Phe Asp
210                 215                 220                 
Asp Glu Ala Phe Asp Glu Ile Ser Asp Asp Ala Lys Asp Phe Ile Ser
225                 230                 235                 240 
Asn Leu Leu Lys Lys Asp Met Lys Asn Arg Leu Asp Cys Thr Gln Cys
245                 250                 255     
Leu Gln His Pro Trp Leu Met Lys Asp Thr Lys Asn Met Glu Ala Lys
260                 265                 270         
Lys Leu Ser Lys Asp Arg Met Lys Lys Tyr Met Ala Arg Arg Lys Trp
275                 280                 285             
Gln Lys Thr Gly Asn Ala Val Arg Ala Ile
290                 295             
<210> 19
<211> 508
<212> PRT
<213> Homo sapiens
<400> 19
Gly Thr Glu Ser Asp Ala Thr Val Lys Lys Lys Pro Ala Pro Lys Thr
1               5                  10                  15      
Pro Pro Lys Ala Ala Met Pro Pro Gln Ile Ile Gln Phe Pro Glu Asp
20                  25                  30          
Gln Lys Val Arg Ala Gly Glu Ser Val Glu Leu Phe Gly Lys Val Thr
35                  40                  45              
Gly Thr Gln Pro Ile Thr Cys Thr Trp Met Lys Phe Arg Lys Gln Ile
50                  55                  60                  
Gln Asp Ser Glu His Ile Lys Val Glu Asn Ser Glu Asn Gly Ser Lys
65                  70                  75                  80  
Leu Thr Ile Leu Ala Ala Arg Gln Glu His Cys Gly Cys Tyr Thr Leu
85                  90                  95      
Leu Val Glu Asn Lys Leu Gly Ser Arg Gln Ala Gln Val Asn Leu Thr
100                 105                 110         
Val Val Asp Lys Pro Asp Pro Pro Ala Gly Thr Pro Cys Ala Ser Asp
115                 120                 125             
Ile Arg Ser Ser Ser Leu Thr Leu Ser Trp Tyr Gly Ser Ser Tyr Asp
130                 135                 140                 
Gly Gly Ser Ala Val Gln Ser Tyr Ser Ile Glu Ile Trp Asp Ser Ala
145                 150                 155                 160 
Asn Lys Thr Trp Lys Glu Leu Ala Thr Cys Arg Ser Thr Ser Phe Asn
165                 170                 175     
Val Gln Asp Leu Leu Pro Asp His Glu Tyr Lys Phe Arg Val Arg Ala
180                 185                 190         
Ile Asn Val Tyr Gly Thr Ser Glu Pro Ser Gln Glu Ser Glu Leu Thr
195                 200                 205             
Thr Val Gly Glu Lys Pro Glu Glu Pro Lys Met Lys Trp Arg Cys Gln
210                 215                 220                 
Thr Asp Asp Glu Lys Glu Pro Glu Val Asp Tyr Arg Thr Val Thr Ile
225                 230                 235                 240 
Asn Thr Glu Gln Lys Val Ser Asp Phe Tyr Asp Ile Glu Glu Arg Leu
245                 250                 255     
Gly Ser Gly Lys Phe Gly Gln Val Phe Arg Leu Val Glu Lys Lys Thr
260                 265                 270         
Arg Lys Val Trp Ala Gly Lys Phe Phe Lys Ala Tyr Ser Ala Lys Glu
275                 280                 285             
Lys Glu Asn Ile Arg Gln Glu Ile Ser Ile Met Asn Cys Leu His His
290                 295                 300                 
Pro Lys Leu Val Gln Cys Val Asp Ala Phe Glu Glu Lys Ala Asn Ile
305                 310                 315                 320 
Val Met Val Leu Glu Ile Val Ser Gly Gly Glu Leu Phe Glu Arg Ile
325                 330                 335     
Ile Asp Glu Asp Phe Glu Leu Thr Glu Arg Glu Cys Ile Lys Tyr Met
340                 345                 350         
Arg Gln Ile Ser Glu Gly Val Glu Tyr Ile His Lys Gln Gly Ile Val
355                 360                 365             
His Leu Asp Leu Lys Pro Glu Asn Ile Met Cys Val Asn Lys Thr Gly
370                 375                 380                 
Thr Arg Ile Lys Leu Ile Asp Phe Gly Leu Ala Arg Arg Leu Glu Asn
385                 390                 395                 400 
Ala Gly Ser Leu Lys Val Leu Phe Gly Thr Pro Glu Phe Val Ala Pro
405                 410                 415     
Glu Val Ile Asn Tyr Glu Pro Ile Ser Tyr Ala Thr Asp Met Trp Ser
420                 425                 430         
Ile Gly Val Ile Cys Tyr Ile Leu Val Ser Gly Leu Ser Pro Phe Met
435                 440                 445             
Gly Asp Asn Asp Asn Glu Thr Leu Ala Asn Val Thr Ser Ala Thr Trp
450                 455                 460                 
Asp Phe Asp Asp Glu Ala Phe Asp Glu Ile Ser Asp Asp Ala Lys Asp
465                 470                 475                 480 
Phe Ile Ser Asn Leu Leu Lys Lys Asp Met Lys Asn Arg Leu Asp Cys
485                 490                 495     
Thr Gln Cys Leu Gln His Pro Trp Leu Met Lys Asp
500                 505             
<210> 20
<211> 106
<212> PRT
<213> Homo sapiens
<400> 20
Pro Tyr Phe Ser Lys Thr Ile Arg Asp Leu Glu Val Val Glu Gly Ser
1               5                  10                  15      
Ala Ala Arg Phe Asp Cys Lys Ile Glu Gly Tyr Pro Asp Pro Glu Val
20                  25                  30          
Val Trp Phe Lys Asp Asp Gln Ser Ile Arg Glu Ser Arg His Phe Gln
35                  40                  45              
Ile Asp Tyr Asp Glu Asp Gly Asn Cys Ser Leu Ile Ile Ser Asp Val
50                  55                  60                  
Cys Gly Asp Asp Asp Ala Lys Tyr Thr Cys Lys Ala Val Asn Ser Leu
65                  70                  75                  80  
Gly Glu Ala Thr Cys Thr Ala Glu Leu Ile Val Glu Thr Met Glu Glu
85                  90                  95      
Gly Glu Gly Glu Gly Glu Glu Glu Glu Glu
100                 105     
<210> 21
<211> 96
<212> PRT
<213> Homo sapiens
<400> 21
Pro Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly
1               5                  10                  15      
Gln Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln
20                  25                  30          
Val Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val
35                  40                  45              
Ser Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val
50                  55                  60                  
Asn Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser
65                  70                  75                  80  
Gly Lys Ala Ser Met Ser Ala Glu Leu Ser Ile Gln Gly Leu Asp Ser
85                  90                  95      
<210> 22
<211> 100
<212> PRT
<213> Homo sapiens
<400>  22
Leu Pro Val Ala Pro Ser Lys Pro Thr Ala Pro Ile Phe Leu Gln Gly 
1               5                   10                  15      
Leu Ser Asp Leu Lys Val Met Asp Gly Ser Gln Val Thr Met Thr Val 
20                  25                  30          
Gln Val Ser Gly Asn Pro Pro Pro Glu Val Ile Trp Leu His Asn Gly 
35                  40                  45              
Asn Glu Ile Gln Glu Ser Glu Asp Phe His Phe Glu Gln Arg Gly Thr 
50                  55                  60                  
Gln His Ser Leu Trp Ile Gln Glu Val Phe Pro Glu Asp Thr Gly Thr 
65                  70                  75                  80  
Tyr Thr Cys Glu Ala Trp Asn Ser Ala Gly Glu Val Arg Thr Gln Ala 
85                  90                  95      
Val Leu Thr Val 
100 
<210> 23
<211> 88
<212> PRT
<213> Homo sapiens
<400> 23
Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly Gln
1               5                  10                  15      
Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln Val
20                  25                  30          
Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val Ser
35                  40                  45              
Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val Asn
50                  55                  60                  
Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser Gly
65                  70                  75                  80  
Lys Ala Ser Met Ser Ala Glu Leu
85              
<210> 24
<211> 94
<212> PRT
<213> Homo sapiens
<400> 24
Ala Pro Ser Phe Ser Ser Val Leu Lys Asp Cys Ala Val Ile Glu Gly
1               5                  10                  15      
Gln Asp Phe Val Leu Gln Cys Ser Val Arg Gly Thr Pro Val Pro Arg
20                  25                  30          
Ile Thr Trp Leu Leu Asn Gly Gln Pro Ile Gln Tyr Ala Arg Ser Thr
35                  40                  45              
Cys Glu Ala Gly Val Ala Glu Leu His Ile Gln Asp Ala Leu Pro Glu
50                  55                  60                  
Asp His Gly Thr Tyr Thr Cys Leu Ala Glu Asn Ala Leu Gly Gln Val
65                  70                  75                  80  
Ser Cys Ser Ala Trp Val Thr Val His Glu Lys Lys Ser Ser
85                  90                  
<210> 25
<211> 112
<212> PRT
<213> Homo sapiens
<400> 25
Lys Lys Ser Ser Arg Lys Ser Glu Tyr Leu Leu Pro Val Ala Pro Ser
1               5                  10                  15      
Lys Pro Thr Ala Pro Ile Phe Leu Gln Gly Leu Ser Asp Leu Lys Val
20                  25                  30          
Met Asp Gly Ser Gln Val Thr Met Thr Val Gln Val Ser Gly Asn Pro
35                  40                  45              
Pro Pro Glu Val Ile Trp Leu His Asn Gly Asn Glu Ile Gln Glu Ser
50                  55                  60                  
Glu Asp Phe His Phe Glu Gln Arg Gly Thr Gln His Ser Leu Trp Ile
65                  70                  75                  80  
Gln Glu Val Phe Pro Glu Asp Thr Gly Thr Tyr Thr Cys Glu Ala Trp
85                  90                  95      
Asn Ser Ala Gly Glu Val Arg Thr Gln Ala Val Leu Thr Val Gln Glu
100                 105                 110         
<210> 26
<211> 100
<212> PRT
<213> Homo sapiens
<400> 26
Ser Met Pro Leu Thr Glu Ala Pro Ala Phe Ile Leu Pro Pro Arg Asn
1               5                  10                  15      
Leu Cys Ile Lys Glu Gly Ala Thr Ala Lys Phe Glu Gly Arg Val Arg
20                  25                  30          
Gly Tyr Pro Glu Pro Gln Val Thr Trp His Arg Asn Gly Gln Pro Ile
35                  40                  45              
Thr Ser Gly Gly Arg Phe Leu Leu Asp Cys Gly Ile Arg Gly Thr Phe
50                  55                  60                  
Ser Leu Val Ile His Ala Val His Glu Glu Asp Arg Gly Lys Tyr Thr
65                  70                  75                  80  
Cys Glu Ala Thr Asn Gly Ser Gly Ala Arg Gln Val Thr Val Glu Leu
85                  90                  95      
Thr Val Glu Gly
100 
<210> 27
<211> 174
<212> PRT
<213> Homo sapiens
<400> 27
Pro Ser Gly Glu Glu Arg Lys Arg Pro Ala Pro Pro Arg Pro Ala Thr
1               5                  10                  15      
Phe Pro Thr Arg Gln Pro Gly Leu Gly Ser Gln Asp Val Val Ser Lys
20                  25                  30          
Ala Ala Asn Arg Arg Ile Pro Met Glu Gly Gln Arg Asp Ser Ala Phe
35                  40                  45              
Pro Lys Phe Glu Ser Lys Pro Gln Ser Gln Glu Val Lys Glu Asn Gln
50                  55                  60                  
Thr Val Lys Phe Arg Cys Glu Val Ser Gly Ile Pro Lys Pro Glu Val
65                  70                  75                  80  
Ala Trp Phe Leu Glu Gly Thr Pro Val Arg Arg Gln Glu Gly Ser Ile
85                  90                  95      
Glu Val Tyr Glu Asp Ala Gly Ser His Tyr Leu Cys Leu Leu Lys Ala
100                 105                 110         
Arg Thr Arg Asp Ser Gly Thr Tyr Ser Cys Thr Ala Ser Asn Ala Gln
115                 120                 125             
Gly Gln Val Ser Cys Ser Trp Thr Leu Gln Val Glu Arg Leu Ala Val
130                 135                 140                 
Met Glu Val Ala Pro Ser Phe Ser Ser Val Leu Lys Asp Cys Ala Val
145                 150                 155                 160 
Ile Glu Gly Gln Asp Phe Val Leu Gln Cys Ser Val Arg Gly
165                 170                 
<210> 28
<211> 97
<212> PRT
<213> Homo sapiens
<400> 28
Pro Ala Phe Lys Gln Lys Leu Gln Asp Val His Val Ala Glu Gly Lys
1               5                  10                  15      
Lys Leu Leu Leu Gln Cys Gln Val Ser Ser Asp Pro Pro Ala Thr Ile
20                  25                  30          
Ile Trp Thr Leu Asn Gly Lys Thr Leu Lys Thr Thr Lys Phe Ile Ile
35                  40                  45              
Leu Ser Gln Glu Gly Ser Leu Cys Ser Val Ser Ile Glu Lys Ala Leu
50                  55                  60                  
Leu Glu Asp Arg Gly Leu Tyr Lys Cys Val Ala Lys Asn Asp Ala Gly
65                  70                  75                  80  
Gln Ala Glu Cys Ser Cys Gln Val Thr Val Asp Asp Ala Pro Ala Ser
85                  90                  95      
Glu
<210> 29
<211> 124
<212> PRT
<213> Homo sapiens
<400> 29
Glu Ser Gln Gly Thr Ala Pro Ala Phe Lys Gln Lys Leu Gln Asp Val
1               5                  10                  15      
His Val Ala Glu Gly Lys Lys Leu Leu Leu Gln Cys Gln Val Ser Ser
20                  25                  30          
Asp Pro Pro Ala Thr Ile Ile Trp Thr Leu Asn Gly Lys Thr Leu Lys
35                  40                  45              
Thr Thr Lys Phe Ile Ile Leu Ser Gln Glu Gly Ser Leu Cys Ser Val
50                  55                  60                  
Ser Ile Glu Lys Ala Leu Leu Glu Asp Arg Gly Leu Tyr Lys Cys Val
65                  70                  75                  80  
Ala Lys Asn Asp Ala Gly Gln Ala Glu Cys Ser Cys Gln Val Thr Val
85                  90                  95      
Asp Asp Ala Pro Ala Ser Glu Asn Thr Lys Ala Pro Glu Met Lys Ser
100                 105                 110         
Arg Arg Pro Lys Ser Ser Leu Pro Pro Val Leu Gly
115                 120                 
<210> 30
<211> 87
<212> PRT
<213> Homo sapiens
<400> 30
Ala Pro Ala Phe Ile Leu Pro Pro Arg Asn Leu Cys Ile Lys Glu Gly
1               5                  10                  15      
Ala Thr Ala Lys Phe Glu Gly Arg Val Arg Gly Tyr Pro Glu Pro Gln
20                  25                  30          
Val Thr Trp His Arg Asn Gly Gln Pro Ile Thr Ser Gly Gly Arg Phe
35                  40                  45              
Leu Leu Asp Cys Gly Ile Arg Gly Thr Phe Ser Leu Val Ile His Ala
50                  55                  60                  
Val His Glu Glu Asp Arg Gly Lys Tyr Thr Cys Glu Ala Thr Asn Gly
65                  70                  75                  80  
Ser Gly Ala Arg Gln Val Thr
85          
<210> 31
<211> 119
<212> PRT
<213> Human
<400> 31
Ser Asn Ala Gln Gly Gln Val Ser Cys Ser Trp Thr Leu Gln Val Glu
1               5                  10                  15      
Arg Leu Ala Val Met Glu Val Ala Pro Ser Phe Ser Ser Val Leu Lys
20                  25                  30          
Asp Cys Ala Val Ile Glu Gly Gln Asp Phe Val Leu Gln Cys Ser Val
35                  40                  45              
Arg Gly Thr Pro Val Pro Arg Ile Thr Trp Leu Leu Asn Gly Gln Pro
50                  55                  60                  
Ile Gln Tyr Ala Arg Ser Thr Cys Glu Ala Gly Val Ala Glu Leu His
65                  70                  75                  80  
Ile Gln Asp Ala Leu Pro Glu Asp His Gly Thr Tyr Thr Cys Leu Ala
85                  90                  95      
Glu Asn Ala Leu Gly Gln Val Ser Cys Ser Ala Trp Val Thr Val His
100                 105                 110         
Glu Lys Lys Ser Ser Arg Lys
115                 
<210> 32
<211> 98
<212> PRT
<213> Human
<400> 32
Gly Gln Arg Asp Ser Ala Phe Pro Lys Phe Glu Ser Lys Pro Gln Ser
1               5                  10                  15      
Gln Glu Val Lys Glu Asn Gln Thr Val Lys Phe Arg Cys Glu Val Ser
20                  25                  30          
Gly Ile Pro Lys Pro Glu Val Ala Trp Phe Leu Glu Gly Thr Pro Val
35                  40                  45              
Arg Arg Gln Glu Gly Ser Ile Glu Val Tyr Glu Asp Ala Gly Ser His
50                  55                  60                  
Tyr Leu Cys Leu Leu Lys Ala Arg Thr Arg Asp Ser Gly Thr Tyr Ser
65                  70                  75                  80  
Cys Thr Ala Ser Asn Ala Gln Gly Gln Val Ser Cys Ser Trp Thr Leu
85                  90                  95      
Gln Val
<210> 33
<211> 82
<212> PRT
<213> Human
<400> 33
Val Thr Ala Ser Leu Gly Gln Ser Val Leu Ile Ser Cys Ala Ile Ala
1               5                  10                  15      
Gly Asp Pro Phe Pro Thr Val His Trp Leu Arg Asp Gly Lys Ala Leu
20                  25                  30          
Cys Lys Asp Thr Gly His Phe Glu Val Leu Gln Asn Glu Asp Val Phe
35                  40                  45              
Thr Leu Val Leu Lys Lys Val Gln Pro Trp His Ala Gly Gln Tyr Glu
50                  55                  60                  
Ile Leu Leu Lys Asn Arg Val Gly Glu Cys Ser Cys Gln Val Ser Leu
65                  70                  75                  80  
Met Leu
<210> 34
<211> 89
<212> PRT
<213> Homo sapiens
<400> 34
Pro Tyr Phe Ser Lys Thr Ile Arg Asp Leu Glu Val Val Glu Gly Ser
1               5                  10                  15      
Ala Ala Arg Phe Asp Cys Lys Ile Glu Gly Tyr Pro Asp Pro Glu Val
20                  25                  30          
Val Trp Phe Lys Asp Asp Gln Ser Ile Arg Glu Ser Arg His Phe Gln
35                  40                  45              
Ile Asp Tyr Asp Glu Asp Gly Asn Cys Ser Leu Ile Ile Ser Asp Val
50                  55                  60                  
Cys Gly Asp Asp Asp Ala Lys Tyr Thr Cys Lys Ala Val Asn Ser Leu
65                  70                  75                  80  
Gly Glu Ala Thr Cys Thr Ala Glu Leu
85