【手続補正書】
【提出日】平成16年1月8日(2004.1.8)
【手続補正１】
【補正対象書類名】明細書
【補正対象項目名】００７５
【補正方法】変更
【補正の内容】
【００７５】
他の態様は特許請求の範囲内である。
【配列表】
SEQUENCE LISTING
<110> Tulane University
<120> Hydrophilic Somatostatin Analogs
<140> JP   2000-583949
<141> 1999-10-20
<150> US   09/196,259
<151> 1998-11-19
<160> 11
<170> FastSEQ for Windows Version 4.0
<210> 1
<211> 14
<212> PRT
<213> Homo sapiens
<220>
<221> MOD_RES
<222> 3,14
<223> Cys at positions 3 and 14 are circularized
<400> 1
Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys
1               5                  10
<210> 2
<211> 12
<212> PRT
<213> Artificial Sequence
<220>
<223> somatostatin analog
<220>
<221> MOD_RES
<222> 6,11
<223> Cys at positions 6 and 11 are circularized
<400> 2
Lys Tyr Lys Tyr Lys Cys Phe Trp Lys Thr Cys Thr
1               5                  10
<210> 3
<211> 12
<212> PRT
<213> Artificial Sequence
<220>
<223> somatostatin analog
<220>
<221> MOD_RES
<222> 6,11
<223> Cys at positions 6 and 11 are circularized
<400> 3
Arg Tyr Arg Tyr Arg Cys Phe Trp Lys Thr Cys Thr
1               5                  10
<210> 4
<211> 14
<212> PRT
<213> Artificial Sequence
<220>
<223> somatostatin analog
<220>
<221> MOD_RES
<222> 8,13
<223> Cys at positions 8 and 13 are circularized
<400> 4
Lys Tyr Lys Tyr Lys Tyr Lys Cys Phe Trp Lys Thr Cys Thr
1               5                  10
<210> 5
<211> 14
<212> PRT
<213> Artificial Sequence
<220>
<223> somatostatin analog
<220>
<221> MOD_RES
<222> 8,13
<223> Cys at positions 8 and 13 are circularized
<400> 5
Lys Tyr Lys Tyr Lys Tyr Lys Cys Phe Trp Lys Thr Cys Thr
1               5                  10
<210> 6
<211> 12
<212> PRT
<213> Artificial Sequence
<220>
<223> somatostatin analog
<220>
<221> MOD_RES
<222> 1,3,5
<223> Xaa = 1,3 diaminopropionic acid
<220>
<221> MOD_RES
<222> 6,11
<223> Cys at positions 6 and 11 are circularized
<400> 6
Xaa Tyr Xaa Tyr Xaa Cys Phe Trp Lys Thr Cys Thr
1               5                  10
<210> 7
<211> 12
<212> PRT
<213> Artificial Sequence
<220>
<223> somatostatin analog
<220>
<221> MOD_RES
<222> 6,11
<223> Cys at positions 6 and 11 are circularized
<400> 7
Lys Tyr Lys Tyr Lys Cys Phe Trp Lys Thr Cys Thr
1               5                  10
<210> 8
<211> 12
<212> PRT
<213> Artificial Sequence
<220>
<223> somatostatin analog
<220>
<221> MOD_RES
<222> 2,4
<223> Xaa = 4-aminophenylalanine, which can be iodinated
<220>
<221> MOD_RES
<222> 6,11
<223> Cys at positions 6 and 11 are circularized
<400> 8
Lys Xaa Lys Xaa Lys Cys Phe Trp Lys Thr Cys Thr
1               5                  10
<210> 9
<211> 12
<212> PRT
<213> Artificial Sequence
<220>
<223> somatostatin analog
<220>
<221> MOD_RES
<222> 1,3,5
<223> Xaa = 1,4-diaminobutanoic acid
<220>
<221> MOD_RES
<222> 6,11
<223> Cys at positions 6 and 11 are circularized
<400> 9
Xaa Tyr Xaa Tyr Xaa Cys Phe Trp Lys Thr Cys Thr
1               5                  10
<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence
<220>
<223> somatostatin analog
<220>
<221> MOD_RES
<222> 4,9
<223> Cys at positions 4 and 9 are circularized
<400> 10
Lys Tyr Lys Cys Phe Trp Lys Thr Cys Thr
1               5                  10
<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence
<220>
<223> somatostatin analog
<220>
<221> MOD_RES
<222> 6,11
<223> Cys at positions 6 and 11 are circularized
<400> 11
Lys Tyr Lys Tyr Lys Cys Phe Trp Lys Thr Cys Thr
1               5                  10