【手続補正書】
【提出日】平成16年3月11日(2004.3.11)
【手続補正１】
【補正対象書類名】明細書
【補正対象項目名】０２８７
【補正方法】変更
【補正の内容】
【０２８７】
【図４１】表３を示す。非必須遺伝子の欠失を有する組換えＭＨＶｓによる
ＲＮＡ合成の定量。
【図４２】表４を示す。再配列ゲノムを有する組換えＭＨＶｓによるＲＮＡ
合成の定量。
【図４３】表５を示す。ワクチン接種と被試験物投与後の臨床徴候の採点表
。
【図４４】表６を示す。ＦＩＰＶ７９−１１４６の種々変異体で最初のワク
チン接種した後の総合臨床スコア。
【図４５】表７を示す。ＦＩＰＶ７９−１１４６の投与後の総合臨床スコア
。
【図４６Ａ】２つの外来遺伝子を有する組換えウイルスの複製。ウイルス（
ＭＨＶ−ＲＬＦＬ、ＭＨＶ−２ａＲＬＳおよびＭＨＶ−ＥＦＬＭ）でのＬＲ７細胞の高 m.o.i.感染の後、感染９時間後に各培地から検体が採取され、そしてこの検体中の感染性が力価測定によって分析された。
【図４６Ｂ】組換えウイルスによるルシフェラーゼの発現。種々の組換えウ
イルスのホタルおよびルネラルシフェラーゼの細胞内発現が、感染（ＭＨＶ−ＲＬＦＬ，ＭＨＶ−２ａＲＬＳおよびＭＨＶ−ＥＦＬＭ）の９時間後に、製造者の説明書（プロメガ(Promega))にしたがって測定された。
【配列表】
SEQUENCE LISTING                               
<110> ウニフェルシテイト  ユトレヒト
スティヒング  フォール  デ  テヒニーセ  ウェーテンスハッペン
<120> 機能的に欠失したゲノムを含むコロナウイルス様の粒子
<160> 80                            
<170> PatentIn Ver. 2.1
<210> 1
<211> 43
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1089
<400> 1
acctgcagga ctaatctaaa ctttattctt tttagggcca cgc                   43    
<210> 2
<211> 19
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1092
<400> 2
ccttaaggaa ttgaactgc                                              19    
<210> 3
<211> 29
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1128
<400> 3
acggtccgac tgcgcgcttg aacacgttg                                   29    
<210> 4
<211> 31
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1130
<400> 4
catgcaagct ttatttgaca tttactaggc t                                31    
<210> 5
<211> 34
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1129
<400> 5
gtcaaataaa gcttgcatga ggcataatct aaac                             34    
<210> 6
<211> 19
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1127
<400> 6
ccagtaagca ataatgtgg                                              19    
<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1261
<400> 7
gctgcttact cctatcatac                                             20    
<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 990
<400> 8
cctgatttat ctctcgattt c                                           21    
<210> 9
<211> 19
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1173
<400> 9
gacttagtcc tctccttga                                              19    
<210> 10
<211> 18
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1260
<400> 10
cttcaacggt ctcagtgc                                               18    
<210> 11
<211> 9
<212> RNA
<213> mouse hepatitis virus
<220> 
<221> misc_feature
<222> (1)..(9)
<223> /note="Consensus transcription regulatory signal"
<400> 11
aaucuaaac                                                         9     
<210> 12
<211> 25
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1C
<400> 12
gtgtatagat atgaaaggta ccgtg                                       25    
<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1097
<400> 13
cgaaccagat cggctagcag                                             20    
<210> 14
<211> 32
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1095
<400> 14
agattagata tcttaggttc tcaacaatgc gg                               32    
<210> 15
<211> 34
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1096
<400> 15
ga acctaaga tatctaatct aaactttaag gatg                             34    
<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1286
<400> 16
ggatactaat ctaaacttta g                                           21    
<210> 17
<211> 30
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1287
<400> 17
ctagctaaag tttagattag atatcctgca                                  30    
<210> 18
<211> 19
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1412
<400> 18
ctgcggacca gttatcatc                                              19    
<210> 19
<211> 34
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1091
<400> 19
gttacaaacc tgaatctcat cttaattctg gtcg                             34    
<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1413
<400> 20
catccgtttc ctttgttctg g                                           21    
<210> 21
<211> 22
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1173
<400> 21
gacttagtcc tctccttgat tg                                          22    
<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1475
<400> 22
gcctaatgca gttgctctcc                                             20    
<210> 23
<211> 25
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 935
<400> 23
gttttagcac agggtgtggc tcatg                                       25    
<210> 24
<211> 18
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1474
<400> 24
ccatcttcca gcggatag                                               18    
<210> 25
<211> 38
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: forward primer
<400> 25
gcggatccat cgaaggtcgt gatttatctc tcgatttc                         38    
<210> 26
<211> 27
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: reverse primer
<400> 26
cg aattcatt ccttgaggtt gatgtag                                     27    
<210> 27
<211> 18
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1244
<400> 27
gccattctca ttgataac                                               18    
<210> 28
<211> 39
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1514
<400> 28
ctgagtctag agtagctagc taatgactaa taagtttag                        39    
<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1245
<400> 29
gcttctgttg agtaatcacc                                             20    
<210> 30
<211> 32
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1513
<400> 30
gctagctact ctagactcag gcggttctaa ac                               32    
<210> 31
<211> 8
<212> DNA
<213> Coronavirus sp.
<220> 
<223> /Note="Infecious Bronchitis Coronavirus TRS"
<400> 31
cttaacaa                                                          8     
<210> 32
<211> 8
<212> DNA
<213> Human Coronavirus sp.
<220> 
<223> /Note="Human Coronavirus TRS"
<400> 32
tctcaact                                                          8     
<210> 33
<211> 50
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
new junction created in recombinant MHV-virus
<400> 33
gaggattgac tatcacagcc cctgcaggaa agacagaaaa tctaaacaat            50    
<210> 34
<211> 77
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
new junction created in recombinant MHV-virus
<400> 34
gaggattgac tatcacagcc cctgcaggac taatctaaac tttattcttt ttagggccac 60    
gcagctcgaa agaaatg                                                77    
<210> 35
<211> 37
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
new junction created in recombinant MHV-virus
<400> 35
gtcaaataaa gcttgcatga ggcataatct aaacatg                          37    
<210> 36
<211> 30
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1287
used for the introduction of an intergenic
promotor sequence (IGS) in front of the renilla
(RL) and firefly luciferase (FL) gene
<400> 36
acgtcctata gattagattt gaaatcgatc                                  30    
<210> 37
<211> 55
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: nucleotide
sequence of pBRDI1 and pBRDI2 around the 5' end of
the FIPV genome sequence
<400> 37
ctcgagtcga aattaatacg actcactata gggtttttaa agtaaagtga gtgta      55    
<210> 38
<211> 36
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: pBRDI sequence
at the pol 1A/pol1B junction
<400> 38
gttattgaag gtgagctctg gactgtgttt tgtaca                           36    
<210> 39
<211> 12
<212> PRT
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: protein
sequence derived from pBRDI sequence at the
pol1A/1B junction
<400> 39
Val Ile Glu Gly Glu Leu Trp Thr Val Phe Cys Thr                  
1               5                  10        
<210> 40
<211> 31
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence:  pBRDI
sequence at the 3' end of the cDNA construct
<400> 40
tagtgataca aaaaaaaaaa aaagcggccg c                                31    
<210> 41
<211> 54
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: nucleotide
sequence at the FIPV pol1B-MHV S transition in
pTMFS1 and pBRDI2
<400> 41
gttaatgtgc catgctgttc gtgtttattc tatttttgcc ctcttgttta gggt       54    
<210> 42
<211> 13
<212> PRT
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: protein
sequence derived from nucleotide sequence at the
FIPV pol1B-MHV S transition in pTMFS1 and pBRDI2
<400> 42
Pro Cys Cys Ser Cys Leu Phe Tyr Phe Cys Pro Leu Val              
1               5                  10            
<210> 43
<211> 11
<212> PRT
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: protein
sequence derived from nucleotide sequence at the
FIPV pol1B-MHV S transition in pTMFS1 and pBRDI2
<400> 43
Met Leu Phe Val Phe Ile Leu Phe Leu Pro Ser                      
1               5                  10    
<210> 44
<211> 25
<212> PRT
<213> mouse hepatitis virus
<400> 44
Ser Ser Tyr Gly Met Ser Glu Ser Ala Asp Ala Asn Gly Ser Ala Glu 
1               5                   10                  15      
Asn Asn Ser Arg Leu Thr Glu Lys Asn 
20                  25  
<210> 45
<211> 25
<212> PRT
<213> Human coronavirus
<400> 45
Tyr Asn Tyr Gly Met Ser Gln Asn Tyr Ala Asp Ala Asn Val Ala Ala 
1               5                   10                  15      
Glu Asn Gln Ser Arg Leu Ser Glu Asn 
20                  25  
<210> 46
<211> 42
<212> PRT
<213> Human coronavirus
<400> 46
Ser Ala Tyr Gln Thr Gln Glu Ala Lys Thr Asn Val Thr Gly Val Asn 
1               5                   10                  15      
Asp Ala Ile Thr Gln Thr Ser Gln Ala Leu Gln Val Ala Asn Gln Asn 
20                  25                  30          
His Thr Ser Arg Gln Ala Asp Thr Gln Gln 
35                  40          
<210> 47
<211> 43
<212> PRT
<213> Feline infectious peritonitis virus
<400> 47
Ala Ala Tyr Gln Thr Asn Lys Gln Asn Asn Thr Gln Gly Lys Val Asn 
1               5                   10                  15      
Asp Ala Ile His Gln Thr Ser Gln Gly Leu Ala Val Ala Lys Ala Thr 
20                  25                  30          
Gln Ser His Thr Val Gln Gln Ser Asn Glu Ser 
35 40              
<210> 48
<211> 36
<212> PRT
<213> Infectious bronchitis virus
<400> 48
Ala Thr Gln His Gln Ser Leu Lys Glu Lys Ala Lys His Arg Ser Leu 
1               5                   10                  15      
Gln Gln Ser Lys Ser Ala Ile Thr Glu Thr Ala Ser Asn Lys Val Gln 
20                  25                  30          
Gln Phe Gln Asn 
35      
<210> 49
<211> 102
<212> PRT
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: peptide HR1
<400> 49
Gly Pro Ile Glu Gly Arg Gln Tyr Arg Ile Asn Gly Leu Gly Val Thr  
1               5                  10                  15    
Met Asn Val Leu Ser Glu Asn Gln Lys Met Ile Ala Ser Ala Phe Asn  
20                  25                  30        
Asn Ala Leu Gly Ala Ile Gln Asp Gly Phe Asp Ala Thr Asn Ser Ala  
35                  40                  45            
Leu Gly Lys Ile Gln Ser Val Val Asn Ala Asn Ala Glu Ala Leu Asn  
50                  55                  60                
Asn Leu Leu Asn Gln Leu Ser Asn Arg Phe Gly Ala Ile Ser Ala Ser  
65                  70                  75                  80
Leu Gln Glu Ile Leu Thr Arg Leu Glu Ala Val Glu Ala Lys Ala Gln  
85                  90                  95    
Ile Asp Arg Leu Ile Asn                                          
100        
<210> 50
<211> 82
<212> PRT
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: peptide HR1a
<400> 50
Gly Pro Asn Gln Lys Met Ile Ala Ser Ala Phe Asn Asn Ala Leu Gly  
1               5                  10                  15    
Ala Ile Gln Asp Gly Phe Asp Ala Thr Asn Ser Ala Leu Gly Lys Ile  
20                  25                  30        
Gln Ser Val Val Asn Ala Asn Ala Glu Ala Leu Asn Asn Leu Leu Asn  
35                  40                  45            
Gln Leu Ser Asn Arg Phe Gly Ala Ile Ser Ala Ser Leu Gln Glu Ile  
50                  55                  60                
Leu Thr Arg Leu Glu Ala Val Glu Ala Lys Ala Gln Ile Asp Arg Leu  
65                  70                  75                  80
Ile Asn                                                          
<210> 51
<211> 47
<212> PRT
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: peptide HR1b
<400> 51
Gly Pro Asn Gln Lys Met Ile Ala Ser Ala Phe Asn Asn Ala Leu Gly  
1               5                  10                  15    
Ala Ile Gln Asp Gly Phe Asp Ala Thr Asn Ser Ala Leu Gly Lys Ile  
20                  25                  30        
Gln Ser Val Val Asn Ala Asn Ala Glu Ala Leu Asn Asn Leu Asn Gln  
35                  40                  45            
<210> 52
<211> 52
<212> PRT
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: peptide HR1c
<400> 52
Gly Pro Ile Glu Gly Arg Asn Ala Asn Ala Glu Ala Leu Asn Asn Leu  
1               5                  10                  15    
Leu Asn Gln Leu Ser Asn Arg Phe Gly Ala Ile Ser Ala Ser Leu Gln  
20                  25                  30        
Glu Ile Leu Thr Arg Leu Glu Ala Val Glu Ala Lys Ala Gln Ile Asp  
35                  40                  45            
Arg Leu Ile Asn                                                  
50        
<210> 53
<211> 17
<212> PRT
<213> mouse hepatitis virus
<400> 53
Phe Glu Lys Leu Tyr Asn Asp Ala Lys Lys Glu Tyr Glu Gly Thr Tyr 
1               5                   10                  15      
Met
<210> 54
<211> 17
<212> PRT
<213> Human coronavirus
<400> 54
Phe Glu Lys Leu Tyr Asn Asp Ala Lys Lys Glu Tyr Glu Gly Thr Tyr 
1               5                   10                  15      
Met 
<210> 55
<211> 27
<212> PRT
<213> Human coronavirus
<400> 55
Val Gln Gln Ser Ser Thr Asn Lys Ser Ala Glu Leu Asn Tyr Thr Val 
1               5                   10                  15      
Gln Lys Leu Gln Thr Asp Asn Ser Trp Asn Arg 
20                  25          
<210> 56
<211> 29
<212> PRT
<213> Feline infectious peritonitis virus
<400> 56
Phe Ile Ala Tyr Gly Asp Asp Phe Arg Ser Glu Lys Leu His Asn Thr 
1               5                   10                  15      
Thr Val Glu Leu Ala Ile Asp Asn Asn Glu Trp Asn Arg 
20                  25                  
<210> 57
<211> 19
<212> PRT
<213> Infectious bronchitis virus
<400> 57
Phe Asp Lys Phe Asn Thr Pro Asp Ser Asp Gly Gln Gly Asp Glu Lys 
1               5                   10                  15      
Ser Ile Lys 
<210> 58
<211> 45
<212> PRT
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: peptide HR2
<400> 58
Gly Pro Ile Glu Gly Arg Asp Leu Ser Leu Asp Phe Glu Lys Leu Asn  
1               5                  10                  15    
Val Thr Leu Leu Asp Leu Thr Tyr Glu Met Asn Arg Ile Gln Asp Ala  
20                  25                  30        
Ile Lys Lys Leu Asn Glu Ser Tyr Ile Asn Leu Lys Glu              
35                  40                  45
<210> 59
<211> 53
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
junction generated in recombinant MHV-virus
<400> 59
gaggattgac tatcacagcc cctgcaggaa agacagaaaa tctaaacaat tta        53    
<210> 60
<211> 41
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
junction generated in recombinant MHV-virus
<400> 60
gaggattgac tatcacagcc ccatctaatc caaacattat g                     41    
<210> 61
<211> 39
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
junction generated in recombinant MHV-virus
<400> 61
agaacctaag atggaaagac agaaaatcta aacaattta                        39    
<210> 62
<211> 26
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
junction generated in recombinant MHV-virus
<400> 62
gatatctaat ctaaacttta aggatg                                      26    
<210> 63
<211> 37
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
junction generated in recombinant MHV-virus
<400> 63
gtcaaataaa gcttgcatga ggcataatct aaacatg                          37    
<210> 64
<211> 38
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
junction generated in recombinant MHV-virus
<400> 64
gtcaaataag cggaaagaca gaaaatctaa acaattta                         38    
<210> 65
<211> 40
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
junction generated in recombinant MHV-virus
<400> 65
agaacctaag atagcttgca tgaggcataa tctaaacatg                       40    
<210> 66
<211> 28
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
junction generated in recombinant MHV-virus
<400> 66
gaggattgac tatcacagcc cccgcgca                                    28    
<210> 67
<211> 32
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
junction generated in recombinant MHV-virus
<400> 67
gtcaaataaa gctatctaat ccaaacatta tg                               32    
<210> 68
<211> 18
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 1  for
SOE-PCR
<400> 68
gccattctca ttgataac                                               18    
<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 2 for
SOE-PCR
<400> 69
gcttctgttg agtaatcacc                                             20    
<210> 70
<211> 34
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 3  for
SOE-PCR
<400> 70
gtcattacag gtcttgtatg acgttcccta gggc                             34    
<210> 71
<211> 20
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 4  for
SOE-PCR
<400> 71
catacaagac ctgtaatgac                                             20    
<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 5  for
SOE-PCR
<400> 72
ggtgattact caacagaagc                                             20    
<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 6 for
SOE-PCR
<400> 73
gcggccgctt tttttttttt                                             20    
<210> 74
<211> 33
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 7 for
SOE-PCR
<400> 74
gaggttacga attaaactga gttataaggc aac                              33    
<210> 75
<211> 16
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 8  for
SOE-PCR
<400> 75
tttaattcgt aacctc                                                 16    
<210> 76
<211> 23
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 9  for
SOE-PCR
<400> 76
caggagccag aagaagacgc taa                                         23    
<210> 77
<211> 21
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 10  for
SOE-PCR
<400> 77
ctcaatctag aggaagacac c                                           21    
<210> 78
<211> 18
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: primer 11  for
SOE-PCR
<400> 78
gaccagtttt agacatcg                                               18    
<210> 79
<211> 14196
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
plasmid pBRDI1
<400> 79
ctcgagtcga aattaatacg actcactata gggtttttaa agtaaagtga gtgtagcgtg 60    
gctataactc ttcttttact ttaactagcc ttgtgctaga tttgtcttcg gacaccaact 120   
cgaactaaac gaaatatttg tctctctatg aaaccataga agacaagcgt tgattatttc 180   
accagtttgg caatcactcc taggaacggg gttgagagaa cggcgcacca gggttccgtc 240   
cctgtttggt aagtcgtcta gtattagctg cggcggttcc gcccgtcgta gttgggtaga 300   
ccgggttccg tcctgtgatc tccctcgccg gccgccagga gaatgagttc caaacaattt 360   
aagatcctcg ttaatgagga ctaccaagtc aacgttccta gccttccttt ccgtgacgca 420   
ctgcaggaaa ttaagtactg ctaccgtaac ggttttgatg gctatgtctt cgtgcctgaa 480   
taccgtcgtg acctagttga ttgcaatcgt aaggatcact acgtcattgg tgttttgggt 540   
aacggaataa gtgatcttaa acctgttctc cttaccgaac cttccgtcat gttgcagggt 600   
ttcattgtta gagccaactg caatggcgtt cttgaggact ttgaccttaa attcgcccgt 660   
actggaaacg gcgccatata tgtggaccaa tacatgtgtg gtgctgatgg aaagccagtt 720   
attgaaggtg agctctggac tgtgttttgt acaagtgtta atacgtcatc atcagaaggt 780   
tttctgattg gtattaacta cttaggacca tactgtgaca aagcaatagt agatggaaat 840   
ataatgcatg ccaattatat attttggaga aactctacaa ttatggctct atcacataac 900   
tcagtcctag acactccaaa atttaagtgc cgttgtaaca atgcacttat tgttaattta 960   
aaagaaaaag aattgaatga aatggtcgtt ggattactaa ggaagggtaa gttactcatt 1020  
agaaataatg gcaagctact aaactttggt aatcatttag ttaatgtgcc atgattgtgc 1080  
tcgtaacttg cctcttgttg ttatgttcat accacacagt tttgagtaca acaaataatg 1140  
aatgcataca agttaacgta acacaattgg ctggcaatga aaaccttatc agagattttc 1200  
tgtttagtaa ctttaaagaa gaaggaagtg tagttgttgg tggttattac cctacagagg 1260  
tgtggtacaa ctgctctaga acagctcgaa ctactgcctt tcagtatttt aataatatac 1320  
atgcctttta ttttgttatg gaagccatgg aaaatagcac tggtaatgca cgtggtaaac 1380  
cattattatt tcatgtgcat ggtgagcctg ttagtgttat tatatcggct tatagggatg 1440  
atgtgcaaca aaggcccctt ttaaaacatg ggttagtgtg cataactaaa aatcgccata 1500  
ttaactatga acaattcacc tccaaccagt ggaattccac atgtacgggt gctgacagaa 1560  
aaattccttt ctctgtcata cccacggaca atggaacaaa aatctatggt cttgagtgga 1620  
atgatgactt tgttacagct tatattagtg gtcgttctta tcacttgaac atcaatacta 1680  
attggtttaa caatgtcaca cttttgtatt cacgctcaag cactgctacc tgggaataca 1740  
gtgctgcata tgcttaccaa ggtgtttcta acttcactta ttacaagtta aataacacca 1800  
atggtctaaa aacctatgaa ttatgtgaag attatgaaca ttgcactggc tatgctacca 1860  
atgtatttgc tccgacatca ggtggttaca tacctgatgg atttagtttt aacaattggt 1920  
tcttgcttac aaatagttcc acttttgtta gtggcaggtt tgtaacaaat caaccattat 1980  
tgattaattg cttgtggcca gtgcccagtt ttggtgtagc agcacaagaa ttttgttttg 2040  
aaggtgcaca gtttagccaa tgtaatggtg tgtctttaaa taacacagtg gatgttatta 2100  
gattcaacct taatttcact gcagatgtac aatctggtat gggtgctaca gtattttcac 2160  
tgaatacaac aggtggtgtc attcttgaaa tttcatgtta tagtgacaca gtgagtgagt 2220  
ctagttctta cagttatggt gaaatcccgt tcggcataac tgacggacca cgatactgtt 2280  
atgtacttta caatggcaca gctcttaaat atttaggaac attaccaccc agtgtaaagg 2340  
aaattgctat tagtaagtgg ggccattttt atattaatgg ttacaatttc tttagcacat 2400  
ttcctattgg ttgtatatct tttaatttaa ccactggtgt tagtggagct ttttggacaa 2460  
ttgcttacac atcgtatact gaagcattag tacaagttga aaacacagct attaaaaatg 2520  
tgacgtattg taacagtcac attaataaca ttaaatgttc tcaacttact gctaatttga 2580  
ataatggatt ttatcctgtt gcttcaagtg aagtaggttt cgttaataag agtgttgtgt 2640  
tattacctag ctttttcaca tacaccgctg tcaatataac cattgatctt ggtatgaagc 2700  
ttagtggtta tggtcaaccc atagcctcga cactaagtaa catcacacta ccaatgcagg 2760  
ataacaatac tgatgtgtac tgtattcgtt ctaaccaatt ctcagtttat gttcattcca 2820  
cttgcaaaag ttctttatgg gacaatattt ttaatcaaga ctgcacggat gttttagagg 2880  
ctacagctgt tataaaaact ggtacttgtc ctttctcatt tgataaattg aacaattact 2940  
tgacttttaa caagttctgt ttgtcgttga gtcctgttgg tgctaattgc aagtttgatg 3000  
ttgctgcacg tacaagaacc aatgagcagg ttgttagaag tctatatgta atatatgaag 3060  
aaggagacaa catagtgggt gtaccgtctg ataatagcgg tctgcacgat ttgtctgtgc 3120  
tacacctaga ctcctgtaca gattacaata tatatggtag aactggtgtt ggtattatta 3180  
gacgaactaa cagtacgcta cttagtggct tatattacac atcactatca ggtgatttgt 3240  
taggctttaa aaatgttagt gatggtgtca tttattctgt gacgccatgt gatgtaagcg 3300  
cacaagcggc tgttattgat ggtgccatag ttggagctat gacttccatt aacagtgaac 3360  
tgttaggtct aacacattgg acaacgacac ctaattttta ttactactct atatataatt 3420  
acacaagtga gaggactcgt ggcactgcaa ttgacagtaa cgatgttgat tgtgaacctg 3480  
tcataaccta ttctaatata ggtgtttgta aaaatggtgc tttggttttt attaacgtca 3540  
cacattctga cggagacgtg caaccaatta gcactggtaa tgtcacgata cctacaaatt 3600  
ttactatatc tgtgcaagtt gaatacatgc aggtttacac tacaccagta tcaatagatt 3660  
gtgcaagata cgtttgtaat ggtaacccta gatgtaacaa attgttaaca caatatgtgt 3720  
ctgcatgtca aactattgaa caagcacttg caatgggtgc cagacttgaa aacatggagg 3780  
ttgattccat gttgtttgtc tcggaaaatg cccttaaatt ggcatctgtt gaggcgttca 3840  
atagtacaga aaatttagat cctatttaca aagaatggcc tagcataggt ggttcttggc 3900  
taggaggtct aaaagatata ctaccgtccc ataatagcaa acgtaagtat ggttctgcta 3960  
tagaagattt gctttttgat aaagttgtaa catctggttt aggtacagtt gatgaagatt 4020  
ataaacgttg tactggtggt tacgacatag cagacttggt gtgtgctcaa tattacaatg 4080  
gcatcatggt tctaccaggt gtagctaatg ctgacaagat gactatgtac acagcatcac 4140  
ttgcaggtgg tataacatta ggtgcacttg gtggtggcgc cgtggctata ccttttgcag 4200  
tagcagtaca ggctagactt aattatgttg ctctacaaac tgatgtattg aataaaaacc 4260  
aacagatcct ggctaatgct ttcaatcaag ctattggtaa cattacacag gcttttggta 4320  
aggttaatga tgctatacat caaacatcac aaggtcttgc cactgttgct aaagcgttgg 4380  
caaaagtgca agatgttgtc aacacacaag ggcaagcttt aagtcacctt acagtacaat 4440  
tgcaaaataa ttttcaagcc attagtagtt ctattagtga tatttataac aggcttgacg 4500  
aactgagtgc tgatgcacaa gttgataggc tgattacagg tagacttaca gcacttaatg 4560  
catttgtgtc tcagactcta accagacaag cagaggttag ggctagtaga caacttgcca 4620  
aagacaaggt taatgaatgt gttaggtctc agtctcagag attcggattc tgtggtaatg 4680  
gtacacattt gttttcacta gcaaatgcag caccaaatgg catgattttc tttcatacag 4740  
tactattacc aacagcttat gaaactgtaa cagcttggtc aggtatttgt gcttcagatg 4800  
gcgatcgcac tttcggactt gtcgttaaag atgtgcagtt gacgttgttt cgtaatctag 4860  
atgacaagtt ctatttgacc cccagaacta tgtatcagcc tagagttgca actagttctg 4920  
attttgttca aattgaaggg tgtgatgtgt tgtttgtcaa cgcgactgta attgatttgc 4980  
ctagtattat acctgactat attgacatta atcaaactgt tcaagacata ttagaaaatt 5040  
acagaccaaa ctggactgta cctgaattta cacttgatat tttcaacgca acctatttaa 5100  
atctgactgg tgaaattgat gacttagagt ttaggtcaga aaagctacat aacactacag 5160  
tagaacttgc cattctcatt gataacatta ataatacatt agtcaatctt gaatggctca 5220  
atagaattga aacttatgta aaatggcctt ggtatgtgtg gctactgata ggtttagtag 5280  
tagtattttg cataccatta ctgctatttt gctgttttag cacaggttgt tgtggatgca 5340  
taggttgttt aggaagttgt tgtcactcta tatgtagtag aagacaattt gaaaattatg 5400  
aaccaattga aaaagtgcat gtccactaaa tttaaagtta aggatgttga ataaattcct 5460  
taagaactaa acttattagt cattacaggt cttgtatgga cattgtcaaa tctattgaca 5520  
tattcgtaga cgctgtactt gacgaacttg accgtgcata ctttgctgta actcttaaag 5580  
tagaatttaa gactggtaaa ctacttgtgt gtataggttt tggtgacaca cttcttgagg 5640  
ctaaggacaa agcgtatgct aagcttggtc tctcctttat tgaagaagtc aatagtcata 5700  
cagttgttta gtattactgt ttacaagttt aaagccaaat tttggtataa actacctttt 5760  
gaaactagac tttgtatcat taaacacaca agacccaaag cattaagtgt tacaaaacaa 5820  
gtaaagagag attatagaaa aattgccatt ctaaattcca tgcgaaaatg attggtggac 5880  
tttttcttaa cactcttagt tttgtaattg ttagtaacca tgttattgtt aataacacag 5940  
caaatgtgca tactacacaa catgaaaatg ttatagtaca acagcattag gttgttagtg 6000  
ctagaacaca aaattattac ccagagttca gcatcgctgt actctttgta tcatttttgg 6060  
ctttgtaccg tagtacaaac tttaagacgt gtgtcggcat cttaatgttt aagattgtat 6120  
caatgacact tgtagggcct atgcttatag catatggtta ctacattgat ggcattgtta 6180  
caataactgt cttagcttta agatttttct acttagcata cttttggtat gttaatagta 6240  
ggtccgaatt tattttatac aatacaacga cactcatgtt tgtacatggc agagctgcac 6300  
cgtttatgag aagttctcac agctctattt atgtcacatt gtatggtggc ataaattata 6360  
tgtttgtgaa tgacctcacg ttgcattttg tagaccctat gcttgtaaga atagcaatac 6420  
gtggcttagc tcatgctgat ctaactgttt ttagagcagt tgaacttctc aatggtgatt 6480  
ttatatatgt attttcacag gagcccgtag ccggtgttta caatgcagcc tcttctcagg 6540  
cggttctaaa cgaaattgac ttaaaagaag aagaagaaga ccataactat gacgttccct 6600  
agggcattta ctatcataga tgaccatggc atggttgtta gcgtcttctt ctggctcctg 6660  
ttgataatta tattgatatt gttttcaata gcattgctaa atgttattaa attgtgcatg 6720  
gtatgttgca atttgggtaa gactattata gtactacctg cacgccatgc atatgatgcc 6780  
tataagacct ttatgcaaac caaggcatat aatcccgacg aagcattttt ggtttgaact 6840  
aaacaaaatg aagtacattt tgctaatact cgcgtgcata attgcatgcg tttatggtga 6900  
acgctactgt gccatgcaag acagtggctt gcagtgtatt aatggcacaa attcaagatg 6960  
tcaaacctgc tttgaacgtg gtgatcttat ttggcatctt gctaactgga acttcagctg 7020  
gtctgtaata ttgattgttt ttataacagt gttacaatat ggcagaccac aatttagctg 7080  
gctcgtttat ggcattaaaa tgctgatcat gtggctatta tggcctattg ttctagcgct 7140  
tacgattttt aatgcatact ctgagtacca agtttccaga tatgtaatgt tcggctttag 7200  
tgttgcaggt gcagttgtaa cgtttgcact ttggatgatg tattttgtga gatctgttca 7260  
gctatataga agaaccaaat catggtggtc ttttaatcct gagactaatg caattctttg 7320  
tgttaatgca ttgggtagaa gttatgtgct tcccttagat ggtactccta caggtgttac 7380  
ccttactcta ctttcaggaa atctatatgc tgaaggtttc aaaatggctg gtggtttaac 7440  
catcgagcat ttgcctaaat acgtcatgat tgctacacct agtagaacca tcgtttatac 7500  
attagttgga aaacaattaa aagcaactac tgccacagga tgggcttact acgtaaaatc 7560  
taaagctggt gattactcaa cagaagcacg tactgacaat ttgagtgaac atgaaaaatt 7620  
attacatatg gtgtaactaa actttcaaat ggccacacag ggacaacgcg tcaactgggg 7680  
agatgaacct tccaaaagac gtggtcgttc taactctcgt ggtcggaaga ataatgatat 7740  
acctttgtca ttctacaacc ccattaccct cgaacaagga tctaaatttt ggaatttatg 7800  
tccgagagac cttgttccca aaggaatagg taataaggat caacaaattg gttattggaa 7860  
tagacagatt cgttatcgta ttgtaaaagg ccagcgtaag gaactcgctg agaggtggtt 7920  
cttttacttc ttaggtacag gacctcatgc tgatgctaaa ttcaaagaca agattgatgg 7980  
agtcttctgg gttgcaaggg atggtgccat gaacaagccc acaacgcttg gcactcgtgg 8040  
aaccaataac gaatccaaac cactgagatt tgatggtaag ataccgccac agtttcagct 8100  
tgaagtgaac cgttctagga acaattcaag gtctggttct cagtctagat ctgtttcaag 8160  
aaacagatct caatctagag gaagacacca ttccaataac cagaataata atgttgagga 8220  
tacaattgta gccgtgcttg aaaaattagg tgttactgac aaacaaaggt cacgttctaa 8280  
acctagagaa cgtagtgatt ccaaacctag ggacacaaca cctaagaatg ccaacaaaca 8340  
cacctggaag aaaactgcag gcaagggaga tgtgacaact ttctatggtg ctagaagtag 8400  
ttcagctaac tttggtgata gtgatctcgt tgccaatggt aacgctgcca aatgctaccc 8460  
tcagatagct gaatgtgttc catcagtgtc tagcataatc tttggcagtc aatggtctgc 8520  
tgaagaagct ggtgatcaag tgaaagtcac gctcactcac acctactacc tgccaaagga 8580  
tgatgccaaa actagtcaat tcctagaaca gattgacgct tacaagcgac cttctgaagt 8640  
ggctaaggat cagaggcaaa gaagatcccg ttctaagtct gctgataaga agcctgagga 8700  
gttgtctgta actcttgtgg aggcatacac agatgtgttt gatgacacac aggttgagat 8760  
gattgatgag gttacgaact aaacgcatgc tcgttttcgt ccatgctgta cttgtaacag 8820  
ctttaatctt actactaatt ggtagaatcc aattactaga aaggttgtta ctcagtcatc 8880  
tgcttaatct tacaacagtc agtaatgttt taggtgtgcc tgacagtagt ctgcgtgtaa 8940  
attgtttgca gcttttgaaa ccagactgcc ttgattttaa tatcttacat aaagttttag 9000  
cagaaaccag gttactagta gtagtactgc gagtgatctt tctagttctt ctagggtttt 9060  
cctgctatac attgttgggt gcattatttt aacatcatga ttgttgtaat ccttgtgtgt 9120  
atctttttgg ctaatggaat taaagctact gctgtgcaaa atgaccttca tgaacatccc 9180  
gttcttacct gggatttatt acagcatttc ataggacata ccctctacat tacaacacac 9240  
caggtcttag cactaccgct tggatctcgt gttgagtgtg agggtatcga aggtttcaat 9300  
tgcacatggc ctggctttca agatcctgca catgatcata ttgatttcta ctttgatctt 9360  
tctaatcctt tctattcatt tgtagataat ttttatattg taagtgaggg aaatcaaaga 9420  
atcaatctca gattggttgg tgctgtgcca aaacaaaaga gattaaatgt tggttgtcat 9480  
acatcatttg ctgttgatct tccatttggg attcagatat accatgacag ggattttcaa 9540  
caccctgttg atggcagaca tctagattgt actcacagag tgtactttgt gaagtactgt 9600  
ccacataacc tgcatggtta ttgctttaat gagaggctga aagtttatga cttgaagcaa 9660  
ttcagaagca agaaggtctt cgacaaaatc aaccaacatc ataaaactga gttataaggc 9720  
aacccgatgt ctaaaactgg tctttccgag gaattacggg tcatcgcgct gcctactctt 9780  
gtacagaatg gtaagcacgt gtaataggag gtacaagcaa ccctattgca tattaggaag 9840  
tttagatttg atttggcaat gctagattta gtaatttaga gaagtttaaa gatccgctat 9900  
gacgagccaa caatggaaga gctaacgtct ggatctagtg attgtttaaa atgtaaaatt 9960  
gtttgaaaat tttccttttg atagtgatac aaaaaaaaaa aaaaaaagcg gccgcaaaat 10020 
tcttgaagac gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata 10080 
atggtttctt agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt 10140 
ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg 10200 
cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt 10260 
cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta 10320 
aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc 10380 
ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa 10440 
gttctgctat gtggcgcggt attatcccgt gttgacgccg ggcaagagca actcggtcgc 10500 
cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt 10560 
acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact 10620 
gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac 10680 
aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata 10740 
ccaaacgacg agcgtgacac cacgatgcct gcagcaatgg caacaacgtt gcgcaaacta 10800 
ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg 10860 
gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat 10920 
aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt 10980 
aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga 11040 
aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa 11100 
gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag 11160 
gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac 11220 
tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc 11280 
gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat 11340 
caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat 11400 
actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct 11460 
acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt 11520 
cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg 11580 
gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta 11640 
cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg 11700 
gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg 11760 
tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc 11820 
tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg 11880 
gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat 11940 
aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc 12000 
agcgagtcag tgagcgagga agcggaagag cgcctgatgc ggtattttct ccttacgcat 12060 
ctgtgcggta tttcacaccg catatggtgc actctcagta caatctgctc tgatgccgca 12120 
tagttaagcc agtatacact ccgctatcgc tacgtgactg ggtcatggct gcgccccgac 12180 
acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca tccgcttaca 12240 
gacaagctgt gaccgtctcc gggagctgca tgtgtcagag gttttcaccg tcatcaccga 12300 
aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc gtgaagcgat tcacagatgt 12360 
ctgcctgttc atccgcgtcc agctcgttga gtttctccag aagcgttaat gtctggcttc 12420 
tgataaagcg ggccatgtta agggcggttt tttcctgttt ggtcactgat gcctccgtgt 12480 
aagggggatt tctgttcatg ggggtaatga taccgatgaa acgagagagg atgctcacga 12540 
tacgggttac tgatgatgaa catgcccggt tactggaacg ttgtgagggt aaacaactgg 12600 
cggtatggat gcggcgggac cagagaaaaa tcactcaggg tcaatgccag cgcttcgtta 12660 
atacagatgt aggtgttcca cagggtagcc agcagcatcc tgcgatgcag atccggaaca 12720 
taatggtgca gggcgctgac ttccgcgttt ccagacttta cgaaacacgg aaaccgaaga 12780 
ccattcatgt tgttgctcag gtcgcagacg ttttgcagca gcagtcgctt cacgttcgct 12840 
cgcgtatcgg tgattcattc tgctaaccag taaggcaacc ccgccagcct agccgggtcc 12900 
tcaacgacag gagcacgatc atgcgcaccc gtggccagga cccaacgctg cccgagatgc 12960 
gccgcgtgcg gctgctggag atggcggacg cgatggatat gttctgccaa gggttggttt 13020 
gcgcattcac agttctccgc aagaattgat tggctccaat tcttggagtg gtgaatccgt 13080 
tagcgaggtg ccgccggctt ccattcaggt cgaggtggcc cggctccatg caccgcgacg 13140 
caacgcgggg aggcagacaa ggtatagggc ggcgcctaca atccatgcca acccgttcca 13200 
tgtgctcgcc gaggcggcat aaatcgccgt gacgatcagc ggtccagtga tcgaagttag 13260 
gctggtaaga gccgcgagcg atccttgaag ctgtccctga tggtcgtcat ctacctgcct 13320 
ggacagcatg gcctgcaacg cgggcatccc gatgccgccg gaagcgagaa gaatcataat 13380 
ggggaaggcc atccagcctc gcgtcgcgaa cgccagcaag acgtagccca gcgcgtcggc 13440 
cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg gaccagtgac 13500 
gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc cgatcatcgt 13560 
cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg gcacctgtcc 13620 
tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca tgccccgcgc 13680 
ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgac gctctccctt 13740 
atgcgactcc tgcattagga agcagcccag tagtaggttg aggccgttga gcaccgccgc 13800 
cgcaaggaat ggtgcatgca aggagatggc gcccaacagt cccccggcca cggggcctgc 13860 
caccataccc acgccgaaac aagcgctcat gagcccgaag tggcgagccc gatcttcccc 13920 
atcggtgatg tcggcgatat aggcgccagc aaccgcacct gtggcgccgg tgatgccggc 13980 
cacgatgcgt ccggcgtaga ggatccacag gacgggtgtg gtcgccatga tcgcgtagtc 14040 
gatagtggct ccaagtagcg aagcgagcag gactgggcgg cggccaaagc ggtcggacag 14100 
tgctccgaga acgggtgcgc atagaaattg catcaacgca tatagcgcta gcagcacgcc 14160 
atagtgactg gcgatgctgt cggaatggac gatccg                           14196 
<210> 80
<211> 13817
<212> DNA
<213> Artificial Sequence
<220> 
<223> Description of Artificial Sequence: sequence of
plasmid pBRDI2
<400> 80
ctcgagtcga aattaatacg actcactata gggtttttaa agtaaagtga gtgtagcgtg 60    
gctataactc ttcttttact ttaactagcc ttgtgctaga tttgtcttcg gacaccaact 120   
cgaactaaac gaaatatttg tctctctatg aaaccataga agacaagcgt tgattatttc 180   
accagtttgg caatcactcc taggaacggg gttgagagaa cggcgcacca gggttccgtc 240   
cctgtttggt aagtcgtcta gtattagctg cggcggttcc gcccgtcgta gttgggtaga 300   
ccgggttccg tcctgtgatc tccctcgccg gccgccagga gaatgagttc caaacaattt 360   
aagatcctcg ttaatgagga ctaccaagtc aacgttccta gccttccttt ccgtgacgca 420   
ctgcaggaaa ttaagtactg ctaccgtaac ggttttgatg gctatgtctt cgtgcctgaa 480   
taccgtcgtg acctagttga ttgcaatcgt aaggatcact acgtcattgg tgttttgggt 540   
aacggaataa gtgatcttaa acctgttctc cttaccgaac cttccgtcat gttgcagggt 600   
ttcattgtta gagccaactg caatggcgtt cttgaggact ttgaccttaa attcgcccgt 660   
actggaaacg gcgccatata tgtggaccaa tacatgtgtg gtgctgatgg aaagccagtt 720   
attgaaggtg agctctggac tgtgttttgt acaagtgtta atacgtcatc atcagaaggt 780   
tttctgattg gtattaacta cttaggacca tactgtgaca aagcaatagt agatggaaat 840   
ataatgcatg ccaattatat attttggaga aactctacaa ttatggctct atcacataac 900   
tcagtcctag acactccaaa atttaagtgc cgttgtaaca atgcacttat tgttaattta 960   
aaagaaaaag aattgaatga aatggtcgtt ggattactaa ggaagggtaa gttactcatt 1020  
agaaataatg gcaagctact aaactttggt aatcatttag ttaatgtgcc atgctgttcg 1080  
tgtttattct atttttgccc tcttgtttag ggtatattgg tgattttaga tgtatccagc 1140  
ttgtgaattc aaacggtgct aatgttagtg ctccaagcat tagcactgag accgttgaag 1200  
tttcacaagg cctggggaca tattatgtgt tagatcgagt ttatttaaat gccacattat 1260  
tgcttactgg ttactacccg gtcgatggtt ctaagtttag aaacctcgct cttaggggaa 1320  
ctaactcagt tagcttgtcg tggtttcaac caccctattt aaatcagttt aatgatggca 1380  
tatttgcgaa ggtgcagaac cttaagacaa gtacgccatc aggtgcaact gcatattttc 1440  
ctactatagt tataggtagt ttgtttggct atacttccta taccgttgta atagagccat 1500  
ataatggtgt tataatggcc tcagtgtgcc agtataccat ttgtcagtta ccttacactg 1560  
attgtaagcc taacactaat ggtaataagc ttatagggtt ttggcacacg gatgtaaaac 1620  
ccccaatttg tgtgttaaag cgaaatttca cgcttaatgt taatgctgat gcattttatt 1680  
ttcattttta ccaacatggt ggtacttttt atgcgtacta tgcggataaa ccctccgcta 1740  
ctacgttttt gtttagtgta tatattggcg atattttaac acagtattat gtgttacctt 1800  
tcatctgcaa cccaacagct ggtagcactt ttgctccgcg ctattgggtt acacctttgg 1860  
ttaagcgcca atatttgttt aatttcaacc agaagggtgt cattactagt gctgttgatt 1920  
gtgctagtag ttataccagt gaaataaaat gtaagaccca gagcatgtta cctagcactg 1980  
gtgtctatga gttatccggt tatacggtcc aaccagttgg agttgtatac cggcgtgttg 2040  
ctaacctccc agcttgtaat atagaggagt ggcttactgc taggtcagtc ccctcccctc 2100  
tcaactggga gcgtaagact tttcagaatt gtaattttaa tttaagcagc ctgttacgtt 2160  
atgttcaggc tgagagtttg ttttgtaata atatcgatgc ttccaaagtg tatggcaggt 2220  
gctttggtag tatttcagtt gataagtttg ctgtaccccg aagtaggcaa gttgatttac 2280  
agcttggtaa ctctggattt ctgcagactg ctaattataa gattgataca gctgccactt 2340  
cgtgtcagct gcattacacc ttgcctaaga ataatgtcac cataaacaac cataacccct 2400  
cgtcttggaa taggaggtat ggctttaatg atgctggcgt ctttggcaaa aaccaacatg 2460  
acgttgttta cgctcagcaa tgttttactg taagatctag ttattgcccg tgtgctcaac 2520  
cggacatagt tagcccttgc actactcaga ctaagcctaa gtctgctttt gttaatgtgg 2580  
gtgaccattg tgaaggctta ggtgttttag aagataattg tggcaatgct gatccacata 2640  
agggttgtat ctgtgccaac aattcattta ttggatggtc acatgatacc tgccttgtta 2700  
atgatcgctg ccaaattttt gctaatatat tgttaaatgg cattaatagt ggtaccacat 2760  
gttccacaga tttgcagttg cctaatactg aagtggttac tggcatttgt gtcaaatatg 2820  
acctctacgg tattactgga caaggtgttt ttaaagaggt taaggctgac tattataata 2880  
gctggcaaac ccttctgtat gatgttaatg gtaatttgaa tggttttcgt gatcttacca 2940  
ctaacaagac ttatacgata aggagctgtt atagtggccg tgtttctgct gcatttcata 3000  
aagatgcacc cgaaccggct ctgctctatc gtaatataaa ttgtagctat gtttttagca 3060  
ataatatttc ccgtgaggag aacccactta attactttga tagttatttg ggttgtgttg 3120  
ttaatgctga taaccgcacg gatgaggcgc ttcctaattg tgatctccgt atgggtgctg 3180  
gcttatgcgt tgattattca aaatcacgca gggctcaccg atcagtttct actggctatc 3240  
ggttaactac atttgagcca tacactccga tgttagttaa tgatagtgtc caatccgttg 3300  
atggattata tgagatgcaa ataccaacca attttactat tgggcaccat gaggagttca 3360  
ttcaaactag atctccaaag gtgactatag attgtgctgc atttgtctgt ggtgataaca 3420  
ctgcatgcag gcagcagttg gttgagtatg gctctttctg tgttaatgtt aatgccattc 3480  
ttaatgaggt taataacctc ttggataata tgcaactaca agttgctagt gcattaatgc 3540  
agggtgttac tataagctcg agactgccag acggcatctc aggccctata gatgacatta 3600  
attttagtcc tctacttgga tgcataggtt caacatgtgc tgaagacggc aatggaccta 3660  
gtgcaatccg agggcgttct gctatagagg atttgttatt tgacaaggtc aaattatctg 3720  
atgttggctt tgtcgaggct tataataatt gcaccggtgg tcaagaagtt cgtgacctcc 3780  
tttgtgtaca atcttttaat ggcatcaaag tattacctcc tgtgttgtca gagagtcaga 3840  
tctctggcta cacaaccggt gctactgcgg cagctatgtt cccaccgtgg tcagcagctg 3900  
ccggtgtgcc atttagttta agtgttcaat atagaattaa tggtttaggt gtcactatga 3960  
atgtgcttag tgagaaccaa aagatgattg ctagtgcttt taacaatgcg ctgggtgcta 4020  
tccaggatgg gtttgatgca accaattctg ctttaggtaa gatccagtcc gttgttaatg 4080  
caaatgctga agcactcaat aacttactaa atcagctttc taacaggttt ggtgctatta 4140  
gtgcttcttt acaagaaatt ctaactcggc ttgaggctgt agaagcaaaa gcccagatag 4200  
atcgtcttat taatggcagg ttaactgcac ttaatgcgta tatatccaag caacttagtg 4260  
atagtacgct tattaaagtt agtgctgctc aggccataga aaaggtcaat gagtgcgtta 4320  
agagccaaac cacgcgtatt aatttctgtg gcaatggtaa tcatatatta tctcttgtcc 4380  
agaatgcgcc ttatggctta tattttatac acttcagcta tgtgccaata tcctttacaa 4440  
ccgcaaatgt gagtcctgga ctttgcattt ctggtgatag aggattagca cctaaagctg 4500  
gatattttgt tcaagatgat ggagaatgga agttcacagg cagttcatat tactaccctg 4560  
aacccattac agataaaaac agtgtcatta tgagtagttg cgcagtaaac tacacaaagg 4620  
cacctgaagt tttcttgaac acttcaatac ctaatccacc cgactttaag gaggagttag 4680  
ataaatggtt taagaatcag acgtctattg cgcctgattt atctctcgat ttcgagaagt 4740  
taaatgttac tttgctggac ctgacgtatg agatgaacag gattcaggat gcaattaaga 4800  
agttaaatga gagctacatc aacctcaagg aagttggcac atatgaaatg tatgtgaaat 4860  
ggccttggta tgtgtggcta ctgataggtt tagtagtagt attttgcata ccattactgc 4920  
tattttgctg ttttagcaca ggttgttgtg gatgcatagg ttgtttagga agttgttgtc 4980  
actctatatg tagtagaaga caatttgaaa attatgaacc aattgaaaaa gtgcatgtcc 5040  
actaaattta aagttaagga tgttgaataa attccttaag aactaaactt attagtcatt 5100  
acaggtcttg tatggacatt gtcaaatcta ttgacatatt cgtagacgct gtacttgacg 5160  
aacttgaccg tgcatacttt gctgtaactc ttaaagtaga atttaagact ggtaaactac 5220  
ttgtgtgtat aggttttggt gacacacttc ttgaggctaa ggacaaagcg tatgctaagc 5280  
ttggtctctc ctttattgaa gaagtcaata gtcatacagt tgtttagtat tactgtttac 5340  
aagtttaaag ccaaattttg gtataaacta ccttttgaaa ctagactttg tatcattaaa 5400  
cacacaagac ccaaagcatt aagtgttaca aaacaagtaa agagagatta tagaaaaatt 5460  
gccattctaa attccatgcg aaaatgattg gtggactttt tcttaacact cttagttttg 5520  
taattgttag taaccatgtt attgttaata acacagcaaa tgtgcatact acacaacatg 5580  
aaaatgttat agtacaacag cattaggttg ttagtgctag aacacaaaat tattacccag 5640  
agttcagcat cgctgtactc tttgtatcat ttttggcttt gtaccgtagt acaaacttta 5700  
agacgtgtgt cggcatctta atgtttaaga ttgtatcaat gacacttgta gggcctatgc 5760  
ttatagcata tggttactac attgatggca ttgttacaat aactgtctta gctttaagat 5820  
ttttctactt agcatacttt tggtatgtta atagtaggtc cgaatttatt ttatacaata 5880  
caacgacact catgtttgta catggcagag ctgcaccgtt tatgagaagt tctcacagct 5940  
ctatttatgt cacattgtat ggtggcataa attatatgtt tgtgaatgac ctcacgttgc 6000  
attttgtaga ccctatgctt gtaagaatag caatacgtgg cttagctcat gctgatctaa 6060  
ctgtttttag agcagttgaa cttctcaatg gtgattttat atatgtattt tcacaggagc 6120  
ccgtagccgg tgtttacaat gcagcctctt ctcaggcggt tctaaacgaa attgacttaa 6180  
aagaagaaga agaagaccat aactatgacg ttccctaggg catttactat catagatgac 6240  
catggcatgg ttgttagcgt cttcttctgg ctcctgttga taattatatt gatattgttt 6300  
tcaatagcat tgctaaatgt tattaaattg tgcatggtat gttgcaattt gggtaagact 6360  
attatagtac tacctgcacg ccatgcatat gatgcctata agacctttat gcaaaccaag 6420  
gcatataatc ccgacgaagc atttttggtt tgaactaaac aaaatgaagt acattttgct 6480  
aatactcgcg tgcataattg catgcgttta tggtgaacgc tactgtgcca tgcaagacag 6540  
tggcttgcag tgtattaatg gcacaaattc aagatgtcaa acctgctttg aacgtggtga 6600  
tcttatttgg catcttgcta actggaactt cagctggtct gtaatattga ttgtttttat 6660  
aacagtgtta caatatggca gaccacaatt tagctggctc gtttatggca ttaaaatgct 6720  
gatcatgtgg ctattatggc ctattgttct agcgcttacg atttttaatg catactctga 6780  
gtaccaagtt tccagatatg taatgttcgg ctttagtgtt gcaggtgcag ttgtaacgtt 6840  
tgcactttgg atgatgtatt ttgtgagatc tgttcagcta tatagaagaa ccaaatcatg 6900  
gtggtctttt aatcctgaga ctaatgcaat tctttgtgtt aatgcattgg gtagaagtta 6960  
tgtgcttccc ttagatggta ctcctacagg tgttaccctt actctacttt caggaaatct 7020  
atatgctgaa ggtttcaaaa tggctggtgg tttaaccatc gagcatttgc ctaaatacgt 7080  
catgattgct acacctagta gaaccatcgt ttatacatta gttggaaaac aattaaaagc 7140  
aactactgcc acaggatggg cttactacgt aaaatctaaa gctggtgatt actcaacaga 7200  
agcacgtact gacaatttga gtgaacatga aaaattatta catatggtgt aactaaactt 7260  
tcaaatggcc acacagggac aacgcgtcaa ctggggagat gaaccttcca aaagacgtgg 7320  
tcgttctaac tctcgtggtc ggaagaataa tgatatacct ttgtcattct acaaccccat 7380  
taccctcgaa caaggatcta aattttggaa tttatgtccg agagaccttg ttcccaaagg 7440  
aataggtaat aaggatcaac aaattggtta ttggaataga cagattcgtt atcgtattgt 7500  
aaaaggccag cgtaaggaac tcgctgagag gtggttcttt tacttcttag gtacaggacc 7560  
tcatgctgat gctaaattca aagacaagat tgatggagtc ttctgggttg caagggatgg 7620  
tgccatgaac aagcccacaa cgcttggcac tcgtggaacc aataacgaat ccaaaccact 7680  
gagatttgat ggtaagatac cgccacagtt tcagcttgaa gtgaaccgtt ctaggaacaa 7740  
ttcaaggtct ggttctcagt ctagatctgt ttcaagaaac agatctcaat ctagaggaag 7800  
acaccattcc aataaccaga ataataatgt tgaggataca attgtagccg tgcttgaaaa 7860  
attaggtgtt actgacaaac aaaggtcacg ttctaaacct agagaacgta gtgattccaa 7920  
acctagggac acaacaccta agaatgccaa caaacacacc tggaagaaaa ctgcaggcaa 7980  
gggagatgtg acaactttct atggtgctag aagtagttca gctaactttg gtgatagtga 8040  
tctcgttgcc aatggtaacg ctgccaaatg ctaccctcag atagctgaat gtgttccatc 8100  
agtgtctagc ataatctttg gcagtcaatg gtctgctgaa gaagctggtg atcaagtgaa 8160  
agtcacgctc actcacacct actacctgcc aaaggatgat gccaaaacta gtcaattcct 8220  
agaacagatt gacgcttaca agcgaccttc tgaagtggct aaggatcaga ggcaaagaag 8280  
atcccgttct aagtctgctg ataagaagcc tgaggagttg tctgtaactc ttgtggaggc 8340  
atacacagat gtgtttgatg acacacaggt tgagatgatt gatgaggtta cgaactaaac 8400  
gcatgctcgt tttcgtccat gctgtacttg taacagcttt aatcttacta ctaattggta 8460  
gaatccaatt actagaaagg ttgttactca gtcatctgct taatcttaca acagtcagta 8520  
atgttttagg tgtgcctgac agtagtctgc gtgtaaattg tttgcagctt ttgaaaccag 8580  
actgccttga ttttaatatc ttacataaag ttttagcaga aaccaggtta ctagtagtag 8640  
tactgcgagt gatctttcta gttcttctag ggttttcctg ctatacattg ttgggtgcat 8700  
tattttaaca tcatgattgt tgtaatcctt gtgtgtatct ttttggctaa tggaattaaa 8760  
gctactgctg tgcaaaatga ccttcatgaa catcccgttc ttacctggga tttattacag 8820  
catttcatag gacataccct ctacattaca acacaccagg tcttagcact accgcttgga 8880  
tctcgtgttg agtgtgaggg tatcgaaggt ttcaattgca catggcctgg ctttcaagat 8940  
cctgcacatg atcatattga tttctacttt gatctttcta atcctttcta ttcatttgta 9000  
gataattttt atattgtaag tgagggaaat caaagaatca atctcagatt ggttggtgct 9060  
gtgccaaaac aaaagagatt aaatgttggt tgtcatacat catttgctgt tgatcttcca 9120  
tttgggattc agatatacca tgacagggat tttcaacacc ctgttgatgg cagacatcta 9180  
gattgtactc acagagtgta ctttgtgaag tactgtccac ataacctgca tggttattgc 9240  
tttaatgaga ggctgaaagt ttatgacttg aagcaattca gaagcaagaa ggtcttcgac 9300  
aaaatcaacc aacatcataa aactgagtta taaggcaacc cgatgtctaa aactggtctt 9360  
tccgaggaat tacgggtcat cgcgctgcct actcttgtac agaatggtaa gcacgtgtaa 9420  
taggaggtac aagcaaccct attgcatatt aggaagttta gatttgattt ggcaatgcta 9480  
gatttagtaa tttagagaag tttaaagatc cgctatgacg agccaacaat ggaagagcta 9540  
acgtctggat ctagtgattg tttaaaatgt aaaattgttt gaaaattttc cttttgatag 9600  
tgatacaaaa aaaaaaaaaa aaagcggccg caaaattctt gaagacgaaa gggcctcgtg 9660  
atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc 9720  
acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat 9780  
atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag 9840  
agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt 9900  
cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt 9960  
gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc 10020 
cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta 10080 
tcccgtgttg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac 10140 
ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa 10200 
ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg 10260 
atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc 10320 
cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg 10380 
atgcctgcag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta 10440 
gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg 10500 
cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg 10560 
tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc 10620 
tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt 10680 
gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt 10740 
gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc 10800 
atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag 10860 
atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa 10920 
aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg 10980 
aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag 11040 
ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg 11100 
ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga 11160 
tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc 11220 
ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc 11280 
acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga 11340 
gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt 11400 
cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg 11460 
aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac 11520 
atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga 11580 
gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg 11640 
gaagagcgcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata 11700 
tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagta tacactccgc 11760 
tatcgctacg tgactgggtc atggctgcgc cccgacaccc gccaacaccc gctgacgcgc 11820 
cctgacgggc ttgtctgctc ccggcatccg cttacagaca agctgtgacc gtctccggga 11880 
gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg cgcgaggcag ctgcggtaaa 11940 
gctcatcagc gtggtcgtga agcgattcac agatgtctgc ctgttcatcc gcgtccagct 12000 
cgttgagttt ctccagaagc gttaatgtct ggcttctgat aaagcgggcc atgttaaggg 12060 
cggttttttc ctgtttggtc actgatgcct ccgtgtaagg gggatttctg ttcatggggg 12120 
taatgatacc gatgaaacga gagaggatgc tcacgatacg ggttactgat gatgaacatg 12180 
cccggttact ggaacgttgt gagggtaaac aactggcggt atggatgcgg cgggaccaga 12240 
gaaaaatcac tcagggtcaa tgccagcgct tcgttaatac agatgtaggt gttccacagg 12300 
gtagccagca gcatcctgcg atgcagatcc ggaacataat ggtgcagggc gctgacttcc 12360 
gcgtttccag actttacgaa acacggaaac cgaagaccat tcatgttgtt gctcaggtcg 12420 
cagacgtttt gcagcagcag tcgcttcacg ttcgctcgcg tatcggtgat tcattctgct 12480 
aaccagtaag gcaaccccgc cagcctagcc gggtcctcaa cgacaggagc acgatcatgc 12540 
gcacccgtgg ccaggaccca acgctgcccg agatgcgccg cgtgcggctg ctggagatgg 12600 
cggacgcgat ggatatgttc tgccaagggt tggtttgcgc attcacagtt ctccgcaaga 12660 
attgattggc tccaattctt ggagtggtga atccgttagc gaggtgccgc cggcttccat 12720 
tcaggtcgag gtggcccggc tccatgcacc gcgacgcaac gcggggaggc agacaaggta 12780 
tagggcggcg cctacaatcc atgccaaccc gttccatgtg ctcgccgagg cggcataaat 12840 
cgccgtgacg atcagcggtc cagtgatcga agttaggctg gtaagagccg cgagcgatcc 12900 
ttgaagctgt ccctgatggt cgtcatctac ctgcctggac agcatggcct gcaacgcggg 12960 
catcccgatg ccgccggaag cgagaagaat cataatgggg aaggccatcc agcctcgcgt 13020 
cgcgaacgcc agcaagacgt agcccagcgc gtcggccgcc atgccggcga taatggcctg 13080 
cttctcgccg aaacgtttgg tggcgggacc agtgacgaag gcttgagcga gggcgtgcaa 13140 
gattccgaat accgcaagcg acaggccgat catcgtcgcg ctccagcgaa agcggtcctc 13200 
gccgaaaatg acccagagcg ctgccggcac ctgtcctacg agttgcatga taaagaagac 13260 
agtcataagt gcggcgacga tagtcatgcc ccgcgcccac cggaaggagc tgactgggtt 13320 
gaaggctctc aagggcatcg gtcgacgctc tcccttatgc gactcctgca ttaggaagca 13380 
gcccagtagt aggttgaggc cgttgagcac cgccgccgca aggaatggtg catgcaagga 13440 
gatggcgccc aacagtcccc cggccacggg gcctgccacc atacccacgc cgaaacaagc 13500 
gctcatgagc ccgaagtggc gagcccgatc ttccccatcg gtgatgtcgg cgatataggc 13560 
gccagcaacc gcacctgtgg cgccggtgat gccggccacg atgcgtccgg cgtagaggat 13620 
ccacaggacg ggtgtggtcg ccatgatcgc gtagtcgata gtggctccaa gtagcgaagc 13680 
gagcaggact gggcggcggc caaagcggtc ggacagtgct ccgagaacgg gtgcgcatag 13740 
aaattgcatc aacgcatata gcgctagcag cacgccatag tgactggcga tgctgtcgga 13800 
atggacgatc cgctcga                                                13817