【手続補正書】
【提出日】平成16年3月24日(2004.3.24)
【手続補正１】
【補正対象書類名】明細書
【補正対象項目名】０１４８
【補正方法】変更
【補正の内容】
【０１４８】
（表４）CYP3A5による期待される薬物代謝
2004527229.tif 000001
2004527229.tif 000002
No.：試行する(running)遺伝子型番号
遺伝子型：アリル組合せから生じる可能性のあるCYP3A5遺伝子型。上側の表に、使用した正確なアリル名の原則を示した。下側の表はより詳細なアリルのリストであり、各々、ふたつの相同染色体における8種の座での変異型の全ての組合せを示している(座1-8は、各々、CYP3A5遺伝子(アクセッション番号:AF280107.1)の位置-20291、-6177、3705、3709/3710、7303、27131/27132、27289および31611に対応する位置を意味し、ここで位置166220は+1と番号付けられ、かつ位置174832は+8613と番号付けられる。)。各変異型は、表2A-Eに列記された3文字配列番号により定義される。配列番号中のワイルドカード(x)は、その表現型がこの染色体のこの遺伝子座では、変異型とは無関係であることを示している。xで置換され得る各遺伝子座について可能性のある変異型は、表2A-Eから抽出することができる。例えば、遺伝子座4の08xは、配列番号081または082を意味し、遺伝子座5の08xは、配列番号087または088のいずれかを意味する。
酵素活性：タンパク質濃度から算出した酵素活性であり、これにより遺伝子型059-061-079-081-111-107/060-062-079-081-111-108の平均タンパク質濃度を、100％と定義した。
用量設定：CYP3A5により分解／活性化される薬剤の用量設定要因は、遺伝子型059-061-079-081-111-107/060-062-079-081-111-108に必要な用量に相関している。要因は、専らCYP3A5によって代謝されることのない薬剤については、CYP3A5酵素の活性分担に応じて、重みを付ける必要があると考えられる。
【配列表】
SEQUENCE LISTING                               
<110> EPIDAUROS Biotechnologie AG
<120> Identification of the genetic determinants of the
polymorphic  CYP3A5 expression
<140> JP   2002-555278
<141> 2001-12-21
<150> EP   00 12 8627.7
<151> 2000-12-28
<150> EP   01 10 0172.4
<151> 2001-01-16
<150> EP   01 11 8884.4
<151> 2001-08-16
<150> US   60/258,684
<151> 2000-12-28
<150> US   60/258,952
<151> 2000-12-29
<150> US   60/262,859
<151> 2001-01-18
<150> US   60/312,825
<151> 2001-08-16
<160> 239                           
<170> PatentIn Ver. 2.1
<210> 1
<211> 21
<212> DNA
<213> Homo sapiens
<400> 1
acaggcacag aaacccacaa g                                           21    
<210> 2
<211> 19
<212> DNA
<213> Homo sapiens
<400> 2
atcgccactt gccttcttc                                              19    
<210> 3
<211> 19
<212> DNA
<213> Homo sapiens
<400> 3
ccctgcttcg gcttgtgca                                              19    
<210> 4
<211> 24
<212> DNA
<213> Homo sapiens
<400> 4
cacagcctgc tttatttgtc atga                                        24    
<210> 5
<211> 21
<212> DNA
<213> Homo sapiens
<400> 5
gatccttggt aggacaagcc t                                           21    
<210> 6
<211> 24
<212> DNA
<213> Homo sapiens
<400> 6
caagcactga tttggtcact tcct                                        24    
<210> 7
<211> 22
<212> DNA
<213> Homo sapiens
<400> 7
gggatgggac cgtaagtgga ac                                          22    
<210> 8
<211> 26
<212> DNA
<213> Homo sapiens
<400> 8
taatcacatt ggagttctga caaatg                                      26    
<210> 9
<211> 30
<212> DNA
<213> Homo sapiens
<400> 9
aaaaacctct tacaaaagta tcatcggata                                  30    
<210> 10
<211> 27
<212> DNA
<213> Homo sapiens
<400> 10
cctactaggt ctctgacttg gaaccat                                     27    
<210> 11
<211> 21
<212> DNA
<213> Homo sapiens
<400> 11
gccgagacgc accattacac t                                           21    
<210> 12
<211> 21
<212> DNA
<213> Homo sapiens
<400> 12
cacccatccc ttcccactca t                                           21    
<210> 13
<211> 28
<212> DNA
<213> Homo sapiens
<400> 13
tgatggttcc aagtcagaga cctagtag                                    28    
<210> 14
<211> 35
<212> DNA
<213> Homo sapiens
<400> 14
aattgtagac atctttctct taagttaatt cccag                            35    
<210> 15
<211> 25
<212> DNA
<213> Homo sapiens
<400> 15
tctgcatgcc aacagtgaac aatct                                       25    
<210> 16
<211> 19
<212> DNA
<213> Homo sapiens
<400> 16
ggcacgcacc agcatgtcc                                              19    
<210> 17
<211> 19
<212> DNA
<213> Homo sapiens
<400> 17
ctggctgagt gccgtggct                                              19    
<210> 18
<211> 25
<212> DNA
<213> Homo sapiens
<400> 18
tgagcgcttc atgtattctg gctat                                       25    
<210> 19
<211> 31
<212> DNA
<213> Homo sapiens
<400> 19
aaatattttc aaagtcacac tctgacaaca g                                31    
<210> 20
<211> 29
<212> DNA
<213> Homo sapiens
<400> 20
taacaggatc tcatgctttt ttcatggct                                   29    
<210> 21
<211> 30
<212> DNA
<213> Homo sapiens
<400> 21
cactccaata ttcacaatag ccactattca                                  30    
<210> 22
<211> 24
<212> DNA
<213> Homo sapiens
<400> 22
actcctacgt atccttccaa gccc                                        24    
<210> 23
<211> 28
<212> DNA
<213> Homo sapiens
<400> 23
gctaagggaa acaggcatag aaacttac                                    28    
<210> 24
<211> 18
<212> DNA
<213> Homo sapiens
<400> 24
ggagcttccc tgccctgc                                               18    
<210> 25
<211> 21
<212> DNA
<213> Homo sapiens
<400> 25
tccttctcca gcacataaat c                                           21    
<210> 26
<211> 21
<212> DNA
<213> Homo sapiens
<400> 26
aaattagaag gtggatggga g                                           21    
<210> 27
<211> 21
<212> DNA
<213> Homo sapiens
<400> 27
gagtaactca ccagccctct g                                           21    
<210> 28
<211> 21
<212> DNA
<213> Homo sapiens
<400> 28
aaacctcaga actccctccc a                                           21    
<210> 29
<211> 23
<212> DNA
<213> Homo sapiens
<400> 29
gacatctctg aatagcttcc ttc                                         23    
<210> 30
<211> 21
<212> DNA
<213> Homo sapiens
<400> 30
gcacatagtt tataacggca a                                           21    
<210> 31
<211> 23
<212> DNA
<213> Homo sapiens
<400> 31
agaacctaag gttgctgtgt gtc                                         23    
<210> 32
<211> 21
<212> DNA
<213> Homo sapiens
<400> 32
tgcaagatgt taccactggg c                                           21    
<210> 33
<211> 20
<212> DNA
<213> Homo sapiens
<400> 33
cgccccacat acactcagaa                                             20    
<210> 34
<211> 21
<212> DNA
<213> Homo sapiens
<400> 34
agaccatttt taggaagctc g                                           21    
<210> 35
<211> 22
<212> DNA
<213> Homo sapiens
<400> 35
caaggggtag tccactgagt tc                                          22    
<210> 36
<211> 18
<212> DNA
<213> Homo sapiens
<400> 36
ctctttggag ttgcagcg                                               18    
<210> 37
<211> 21
<212> DNA
<213> Homo sapiens
<400> 37
aggtgagtct aactcagctt g                                           21    
<210> 38
<211> 21
<212> DNA
<213> Homo sapiens
<400> 38
gacagctaaa gtgtgtgagg g                                           21    
<210> 39
<211> 21
<212> DNA
<213> Homo sapiens
<400> 39
aatgggttcc agttgagaat c                                           21    
<210> 40
<211> 21
<212> DNA
<213> Homo sapiens
<400> 40
attgttgtgc ctgatttcaa g                                           21    
<210> 41
<211> 19
<212> DNA
<213> Homo sapiens
<400> 41
agaagccata gggaggttg                                              19    
<210> 42
<211> 20
<212> DNA
<213> Homo sapiens
<400> 42
gactgtcctc caagcattct                                             20    
<210> 43
<211> 21
<212> DNA
<213> Homo sapiens
<400> 43
gatgccatga tgaggagtgt g                                           21    
<210> 44
<211> 19
<212> DNA
<213> Homo sapiens
<400> 44
accagggcca gcaatattg                                              19    
<210> 45
<211> 25
<212> DNA
<213> Homo sapiens
<400> 45
aaatacttca cgaatactat gatca                                       25    
<210> 46
<211> 24
<212> DNA
<213> Homo sapiens
<400> 46
cagggacata attgattatc tttg                                        24    
<210> 47
<211> 19
<212> DNA
<213> Homo sapiens
<400> 47
tactggttgg gaggtggag                                              19    
<210> 48
<211> 23
<212> DNA
<213> Homo sapiens
<400> 48
catgatgttc ttaatgctac agg                                         23    
<210> 49
<211> 25
<212> DNA
<213> Homo sapiens
<400> 49
gaagagttca agatacatgg tgtta                                       25    
<210> 50
<211> 23
<212> DNA
<213> Homo sapiens
<400> 50
tgcacaacac tctacacaga ctc                                         23    
<210> 51
<211> 11
<212> DNA
<213> Homo sapiens
<400> 51
tgggcttgca a                                                      11    
<210> 52
<211> 11
<212> DNA
<213> Homo sapiens
<400> 52
tgggcgtgca a                                                      11    
<210> 53
<211> 11
<212> DNA
<213> Homo sapiens
<400> 53
gcatgggtaa a                                                      11    
<210> 54
<211> 11
<212> DNA
<213> Homo sapiens
<400> 54
gcatgagtaa a                                                      11    
<210> 55
<211> 11
<212> DNA
<213> Homo sapiens
<400> 55
ggggtgtgtg c                                                      11    
<210> 56
<211> 11
<212> DNA
<213> Homo sapiens
<400> 56
ggggtatgtg c                                                      11    
<210> 57
<211> 11
<212> DNA
<213> Homo sapiens
<400> 57
tgtgcgattc t                                                      11    
<210> 58
<211> 11
<212> DNA
<213> Homo sapiens
<400> 58
tgtgcaattc t                                                      11    
<210> 59
<211> 11
<212> DNA
<213> Homo sapiens
<400> 59
gccccacctc c                                                      11    
<210> 60
<211> 11
<212> DNA
<213> Homo sapiens
<400> 60
gccccgcctc c                                                      11    
<210> 61
<211> 11
<212> DNA
<213> Homo sapiens
<400> 61
ctcacactgg g                                                      11    
<210> 62
<211> 11
<212> DNA
<213> Homo sapiens
<400> 62
ctcacgctgg g                                                      11    
<210> 63
<211> 11
<212> DNA
<213> Homo sapiens
<400> 63
gagacgcacc a                                                      11    
<210> 64
<211> 11
<212> DNA
<213> Homo sapiens
<400> 64
gagacacacc a                                                      11    
<210> 65
<211> 11
<212> DNA
<213> Homo sapiens
<400> 65
tgtgtgtggg a                                                      11    
<210> 66
<211> 11
<212> DNA
<213> Homo sapiens
<400> 66
tgtgtatggg a                                                      11    
<210> 67
<211> 11
<212> DNA
<213> Homo sapiens
<400> 67
atccatgtat a                                                      11    
<210> 68
<211> 11
<212> DNA
<213> Homo sapiens
<400> 68
atccacgtat a                                                      11    
<210> 69
<211> 11
<212> DNA
<213> Homo sapiens
<400> 69
catcttaccc c                                                      11    
<210> 70
<211> 11
<212> DNA
<213> Homo sapiens
<400> 70
catctcaccc c                                                      11    
<210> 71
<211> 11
<212> DNA
<213> Homo sapiens
<400> 71
tctattgcta t                                                      11    
<210> 72
<211> 11
<212> DNA
<213> Homo sapiens
<400> 72
tctatagcta t                                                      11    
<210> 73
<211> 11
<212> DNA
<213> Homo sapiens
<400> 73
ggcagggaag c                                                      11    
<210> 74
<211> 11
<212> DNA
<213> Homo sapiens
<400> 74
ggcagagaag c                                                      11    
<210> 75
<211> 11
<212> DNA
<213> Homo sapiens
<400> 75
ccaggcaaac a                                                      11    
<210> 76
<211> 11
<212> DNA
<213> Homo sapiens
<400> 76
ccaggtaaac a                                                      11    
<210> 77
<211> 11
<212> DNA
<213> Homo sapiens
<400> 77
tcaaggagaa g                                                      11    
<210> 78
<400> 78
000
<210> 79
<211> 11
<212> DNA
<213> Homo sapiens
<400> 79
gtacacatgg a                                                      11    
<210> 80
<211> 11
<212> DNA
<213> Homo sapiens
<400> 80
gtacatatgg a                                                      11    
<210> 81
<211> 10
<212> DNA
<213> Homo sapiens
<400> 81
catggacttt                                                        10    
<210> 82
<211> 11
<212> DNA
<213> Homo sapiens
<400> 82
catgggactt t                                                      11    
<210> 83
<211> 11
<212> DNA
<213> Homo sapiens
<400> 83
gatagcaggc c                                                      11    
<210> 84
<211> 11
<212> DNA
<213> Homo sapiens
<400> 84
gatagtaggc c                                                      11    
<210> 85
<211> 11
<212> DNA
<213> Homo sapiens
<400> 85
agaatcgggc t                                                      11    
<210> 86
<211> 11
<212> DNA
<213> Homo sapiens
<400> 86
agaatagggc t                                                      11    
<210> 87
<211> 11
<212> DNA
<213> Homo sapiens
<400> 87
ttattctgtc t                                                      11    
<210> 88
<211> 11
<212> DNA
<213> Homo sapiens
<400> 88
ttattatgtc t                                                      11    
<210> 89
<400> 89
000
<210> 90
<211> 11
<212> DNA
<213> Homo sapiens
<400> 90
cctaaaaaat g                                                      11    
<210> 91
<211> 11
<212> DNA
<213> Homo sapiens
<400> 91
tcttttatct t                                                      11    
<210> 92
<211> 11
<212> DNA
<213> Homo sapiens
<400> 92
tctttgatct t                                                      11    
<210> 93
<211> 11
<212> DNA
<213> Homo sapiens
<400> 93
gagtctgcac a                                                      11    
<210> 94
<211> 11
<212> DNA
<213> Homo sapiens
<400> 94
gagtccgcac a                                                      11    
<210> 95
<400> 95
000
<210> 96
<211> 11
<212> DNA
<213> Homo sapiens
<400> 96
agtcgtcaag a                                                      11    
<210> 97
<211> 11
<212> DNA
<213> Homo sapiens
<400> 97
aggaagtatt c                                                      11    
<210> 98
<211> 11
<212> DNA
<213> Homo sapiens
<400> 98
aggaattatt c                                                      11    
<210> 99
<211> 11
<212> DNA
<213> Homo sapiens
<400> 99
agagagcttc a                                                      11    
<210> 100
<211> 11
<212> DNA
<213> Homo sapiens
<400> 100
agagaacttc a                                                      11    
<210> 101
<211> 11
<212> DNA
<213> Homo sapiens
<400> 101
cttcaatagt a                                                      11    
<210> 102
<211> 11
<212> DNA
<213> Homo sapiens
<400> 102
cttcagtagt a                                                      11    
<210> 103
<211> 11
<212> DNA
<213> Homo sapiens
<400> 103
tccaacttat g                                                      11    
<210> 104
<211> 11
<212> DNA
<213> Homo sapiens
<400> 104
tccaaattat g                                                      11    
<210> 105
<211> 11
<212> DNA
<213> Homo sapiens
<400> 105
cgaaactaca t                                                      11    
<210> 106
<211> 11
<212> DNA
<213> Homo sapiens
<400> 106
cgaaattaca t                                                      11    
<210> 107
<211> 11
<212> DNA
<213> Homo sapiens
<400> 107
aaggatttct a                                                      11    
<210> 108
<211> 11
<212> DNA
<213> Homo sapiens
<400> 108
aaggacttct a                                                      11    
<210> 109
<211> 11
<212> DNA
<213> Homo sapiens
<400> 109
agctccgttg t                                                      11    
<210> 110
<211> 11
<212> DNA
<213> Homo sapiens
<400> 110
agctctgttg t                                                      11    
<210> 111
<211> 10
<212> DNA
<213> Homo sapiens
<400> 111
cacctaccta                                                        10    
<210> 112
<211> 11
<212> DNA
<213> Homo sapiens
<400> 112
caccttacct a                                                      11    
<210> 113
<211> 830
<212> DNA
<213> Homo sapiens
<400> 113
tggtcaccca ccatgtgtac agtaccctgc tagggtccag ggtcatgaaa gtaaataata 60    
ccagactgtg cccttgagga actcacctct gctaagggaa acaggcacag aaacccacaa 120   
gggtggtaga gaggaaatag gacaatagga ctgtgtgagg gggataggag gcacccagag 180   
gaggaaatgg ttacatctgt gtgaggaggt tggtaaggaa agactttaat agaaggggtc 240   
tgtctggctg ggcgtgcaag gatgtgtagg agtcatctag ggggcacaag tacactccag 300   
gcagagggaa ttgcatgggt aaagatctgc agttgtggct tgtggggatg gatttcaagt 360   
attctggaat gaagacagcc atggaaacaa gggcaggtga gaggatattt aagaggcttc 420   
atgccaatgg ctccacttca gtttctgata agaactcagg ttccgtggac tccctgataa 480   
aactgattaa gttgtttatg attccccata gaatatgaac tcaaaggagg taagcaaagg 540   
ggtgtgtgcg attctttgct actggctgca gctgcagccc cgcctccttc tccagcacat 600   
aaacatttca gcagcttgac ctaagactgc tgtgcagggc agggatgctc caggcagaca 660   
gcccagcaaa caacagcaca cagctgaaag taagactcag aggagacagt tgaagaaggc 720   
aagtggcgat ggacctcatc ccaaatttgg cggtggaaac ctggcttctc ctggctgtca 780   
gcctggtgct cctctatctg tcagtaactg tccagattcc tctcctctgt            830   
<210> 114
<211> 830
<212> DNA
<213> Homo sapiens
<400> 114
tggtcaccca ccatgtgtac agtaccctgc tagggtccag ggtcatgaaa gtaaataata 60    
ccagactgtg cccttgagga actcacctct gctaagggaa acaggcacag aaacccacaa 120   
gggtggtaga gaggaaatag gacaatagga ctgtgtgagg gggataggag gcacccagag 180   
gaggaaatgg ttacatctgt gtgaggaggt tggtaaggaa agactttaat agaaggggtc 240   
tgtctggctg ggcttgcaag gatgtgtagg agtcatctag ggggcacaag tacactccag 300   
gcagagggaa ttgcatgagt aaagatctgc agttgtggct tgtggggatg gatttcaagt 360   
attctggaat gaagacagcc atggaaacaa gggcaggtga gaggatattt aagaggcttc 420   
atgccaatgg ctccacttca gtttctgata agaactcagg ttccgtggac tccctgataa 480   
aactgattaa gttgtttatg attccccata gaatatgaac tcaaaggagg taagcaaagg 540   
ggtgtgtgcg attctttgct actggctgca gctgcagccc cacctccttc tccagcacat 600   
aaacatttca gcagcttgac ctaagactgc tgtgcagggc agggatgctc caggcagaca 660   
gcccagcaaa caacagcaca cagctgaaag taagactcag aggagacagt tgaagaaggc 720   
aagtggcgat ggacctcatc ccaaatttgg cggtggaaac ctggcttctc ctggctgtca 780   
gcctggtgct cctctatctg tcagtaactg tccagattcc tctcctctgt            830   
<210> 115
<211> 830
<212> DNA
<213> Homo sapiens
<400> 115
tggtcaccca ccatgtgtac agtaccctgc tagggtccag ggtcatgaaa gtaaataata 60    
ccagactgtg cccttgagga actcacctct gctaagggaa acaggcacag aaacccacaa 120   
gggtggtaga gaggaaatag gacaatagga ctgtgtgagg gggataggag gcacccagag 180   
gaggaaatgg ttacatctgt gtgaggaggt tggtaaggaa agactttaat agaaggggtc 240   
tgtctggctg ggcttgcaag gatgtgtagg agtcatctag ggggcacaag tacactccag 300   
gcagagggaa ttgcatgggt aaagatctgc agttgtggct tgtggggatg gatttcaagt 360   
attctggaat gaagacagcc atggaaacaa gggcaggtga gaggatattt aagaggcttc 420   
atgccaatgg ctccacttca gtttctgata agaactcagg ttccgtggac tccctgataa 480   
aactgattaa gttgtttatg attccccata gaatatgaac tcaaaggagg taagcaaagg 540   
ggtatgtgcg attctttgct actggctgca gctgcagccc cacctccttc tccagcacat 600   
aaacatttca gcagcttgac ctaagactgc tgtgcagggc agggatgctc caggcagaca 660   
gcccagcaaa caacagcaca cagctgaaag taagactcag aggagacagt tgaagaaggc 720   
aagtggcgat ggacctcatc ccaaatttgg cggtggaaac ctggcttctc ctggctgtca 780   
gcctggtgct cctctatctg tcagtaactg tccagattcc tctcctctgt            830   
<210> 116
<211> 830
<212> DNA
<213> Homo sapiens
<400> 116
tggtcaccca ccatgtgtac agtaccctgc tagggtccag ggtcatgaaa gtaaataata 60    
ccagactgtg cccttgagga actcacctct gctaagggaa acaggcacag aaacccacaa 120   
gggtggtaga gaggaaatag gacaatagga ctgtgtgagg gggataggag gcacccagag 180   
gaggaaatgg ttacatctgt gtgaggaggt tggtaaggaa agactttaat agaaggggtc 240   
tgtctggctg ggcttgcaag gatgtgtagg agtcatctag ggggcacaag tacactccag 300   
gcagagggaa ttgcatgggt aaagatctgc agttgtggct tgtggggatg gatttcaagt 360   
attctggaat gaagacagcc atggaaacaa gggcaggtga gaggatattt aagaggcttc 420   
atgccaatgg ctccacttca gtttctgata agaactcagg ttccgtggac tccctgataa 480   
aactgattaa gttgtttatg attccccata gaatatgaac tcaaaggagg taagcaaagg 540   
ggtgtgtgca attctttgct actggctgca gctgcagccc cacctccttc tccagcacat 600   
aaacatttca gcagcttgac ctaagactgc tgtgcagggc agggatgctc caggcagaca 660   
gcccagcaaa caacagcaca cagctgaaag taagactcag aggagacagt tgaagaaggc 720   
aagtggcgat ggacctcatc ccaaatttgg cggtggaaac ctggcttctc ctggctgtca 780   
gcctggtgct cctctatctg tcagtaactg tccagattcc tctcctctgt            830   
<210> 117
<211> 775
<212> DNA
<213> Homo sapiens
<400> 117
ggagtgacct gattttccag gtgctgtctg tcaccccttt ctttgactag gaaagggaac 60    
tccttgaccc cttgcgcttc tcaagtgagg caatgcctcg ccctgcttcg gcttgtgcac 120   
agcacgctgc acccactgtc ctgcacccac tgtctggcac tccctagtga gatgaacccg 180   
gtacctcaga tgaaaatgca gaaatcaccc gtcttctgtg tcactcacgc tgggagctgt 240   
agaccggagc tgttcctatt cggccatctt ggctccaccc cccgagtttt ggcttttaat 300   
tgaaagtgta ttgatgtggg aaggagataa tgccatgcat ttatgagcac atattagagg 360   
gtctgagaca atgcatgtga taaaaggtca cctaaggaag aaaaaaagaa caagggaaga 420   
cactggaaag aacgtgatgc tgggagtccc tgggccacca aagtctggag aaaagtggta 480   
accacaaggc tcccagccta gtttcactga agacctcgac actaggtgac ttatgggatc 540   
cttggtagga caagccttga aaagttttac aatagcaaat gtggacgttg tcagaaccaa 600   
atgatgtcac gtgtgtattt gtgtgtgtgt gtcagtgtgt gtgtttaaaa atcatgacaa 660   
ataaagcagg ctgtgaagag gggattccca tgctcgtgtg cctgataaca caactatcac 720   
aaacgctttg cgaaaccaca agtttgcaca aaggcaatcc caaccttaca caaaa      775   
<210> 118
<211> 1110
<212> DNA
<213> Homo sapiens
<400> 118
taatgaaaat aagaattatt ttgatggctc taacagtgac atttatatca tctgttttat 60    
ctggagcatt ctataataag tttatattaa gcaaatcaat aaaaacctct tacaaaagta 120   
tcatcggata ctttcctgaa cattaaggag aaatctatag aactgaatga atgagaacca 180   
acaagtaaat atatgtgatc attgtaacca ttgttggtgt ggggcatttg tcagaactcc 240   
aatgtgatta ttaacatagg tgagaattaa tccactgtga ctttgcccat tgcttagaaa 300   
gaacattcat agtttaatta tgcctttttt gaccaagcac agtggctcat gcctgtaatc 360   
ccagcacttt gggaggccga ggtgggtgga tcacctgagg tcaggagttc gagaccagcc 420   
tgaccaacat ggtgaaaccc catctctact aaaaatacaa aaattagcta ggtgtggtgg 480   
tatgcaccta taatctcagc tacccaggag gctgaggcag gagaatcact tgaacctgga 540   
ggcagaggtt gcagtgagcc gagacacacc attacactcc agcctgggtg acagagtgag 600   
attccatctc aaaaaaaaaa aaaaaaaatt atgccttttt gaagcacata cattttataa 660   
catacaactg aatcccttat tatattatta gttttgattt aatgttttca aaccatctcc 720   
cctgatattt ctgggagatg ggaaacatgt tttcttacac ctcttgcatt ccattctcaa 780   
ctcccaactg tcttactgca atgaacactt aataagaaac agtcaattgg tcaattgatt 840   
gggcaacagg ctaaacacac tcattccttg tctgttccca cttctttctt tactttccct 900   
tcctgagtaa cttatcctaa agtcattagg tgggtggcag ccagatggtg gccacacatt 960   
aaggtagaaa agagagtgtc atgatggttc caagtcagag acctagtagg gtgaggatca 1020  
agtaggtgtt cacgtggaga aacagcccgg cctgtgtgtg ggagtccaag caagcagaga 1080  
aaatgtcgac acagaggggt ggcctgaaaa                                  1110  
<210> 119
<211> 837
<212> DNA
<213> Homo sapiens
<400> 119
caaaaattag ctaggtgtgg tggtatgcac ctataatctc agctacccag gaggctgagg 60    
caggagaatc acttgaacct ggaggcagag gttgcagtga gccgagacgc accattacac 120   
tccagcctgg gtgacagagt gagattccat ctcaaaaaaa aaaaaaaaaa attatgcctt 180   
tttgaagcac atacatttta taacatacaa ctgaatccct tattatatta ttagttttga 240   
tttaatgttt tcaaaccatc tcccctgata tttctgggag atgggaaaca tgttttctta 300   
cacctcttgc attccattct caactcccaa ctgtcttact gcaatgaaca cttaataaga 360   
aacagtcaat tggtcaattg attgggcaac aggctaaaca cactcattcc ttgtctgttc 420   
ccacttcttt ctttactttc ccttcctgag taacttatcc taaagtcatt aggtgggtgg 480   
cagccagatg gtggccacac attaaggtag aaaagagagt gtcatgatgg ttccaagtca 540   
gagacctagt agggtgagga tcaagtaggt gttcacgtgg agaaacagcc cggcctgtgt 600   
atgggagtcc aagcaagcag agaaaatgtc gacacagagg ggtggcctga aaaagcagcc 660   
agagcctaaa cagggcatgg agaacatatt tagggcatga ggtgaggagg gcatccatga 720   
gtgggaaggg atgggtgagg tttcactaca taaaggggat tgatgaaata agtaaataaa 780   
gtatactgga agccaggtgt gtcacttttg cagaaaagag tcatggattc agaaagg    837   
<210> 120
<211> 1197
<212> DNA
<213> Homo sapiens
<400> 120
ttctttcttt actttccctt cctgagtaac ttatcctaaa gtcattaggt gggtggcagc 60    
cagatggtgg ccacacatta aggtagaaaa gagagtgtca tgatggttcc aagtcagaga 120   
cctagtaggg tgaggatcaa gtaggtgttc acgtggagaa acagcccggc ctgtgtgtgg 180   
gagtccaagc aagcagagaa aatgtcgaca cagaggggtg gcctgaaaaa gcagccagag 240   
cctaaacagg gcatggagaa catatttagg gcatgaggtg aggagggcat ccatgagtgg 300   
gaagggatgg gtgaggtttc actacataaa ggggattgat gaaataagta aataaagtat 360   
actggaagcc aggtgtgtca cttttgcaga aaagagtcat ggattcagaa agggagaaaa 420   
ctagcaggaa tcctatgaaa ttagattaaa atggatgtat ccacgtatat tcataccctt 480   
ctagatagat aaatggttag ataggtgata aaaagataac aagaggacaa gataattaga 540   
tagacataaa tgtatgtatg tgtttgtgtg tgtgtacaaa aaaacatata ctccctactt 600   
ctctccactg atagggctag gtaacaatgg catttcaata gcaatgagca cacttagtgg 660   
ccagatcttg gcttattaat accattttcc actgaaagga accagagctt tttagagaaa 720   
tggctgattc cagggccagg attaagaatg ttcaagataa gcctaggata cattttgtgc 780   
caggaagcaa gaagatgttc aaatgatttc caagtaatgt ttggaaatga tatttgaaaa 840   
tgatttccaa atgatatttc caaatgattt ccaaatgata tatggaaaca cttaaagact 900   
ccactaaaga actattagat ctgataaaca aattcagtaa tgttgctgga tacaaaatca 960   
acatacaaaa accagtagca tttctgcatg ccaacagtga acaatctggc aaaaataaaa 1020  
aatgtaatcc catttacaat aaccccaaat aaaactaaat acctgggaat taacttaaga 1080  
gaaagatgtc tacaattaat attgtaaaac actgatgaag gaaattgaag aagacacaaa 1140  
aaagaaggat attccatgtt tatatattgt aagcattaat attgttaaaa atgtcca    1197  
<210> 121
<211> 817
<212> DNA
<213> Homo sapiens
<400> 121
caaagcaaaa atggacaaat ggatcagatc aagttaaaaa gcttctgtac cacaaagaaa 60    
gcaatcaaca aagtgaagac acaaaccaca gaatgggaga aaatattttc aaagtcacac 120   
tctgacaaca gattaatagc cagaatacat gaagcgctca aacaactctg taaggaaaaa 180   
tctaataatc caatcaaaaa atgggcaaaa tttgaataga catttttcaa aagaagacat 240   
acaaatgcca cataggcata tgataaggtg ctcaacatca ctggtcatta gagaaatgca 300   
aatcaaaacc acaatgagat atcatctcac cccagctaaa atggttttta tccaaaagac 360   
aggcaacaac aaatgccagc gagaatgtgg agaaaaggga acccttgtac actgttggtg 420   
taaattagtg caaccactat agagaacaat ttggaggttc ctcaaaacat taaaattaac 480   
attaaataga gctaccacaa tatccagaaa tccccatgct gggtatatac ctggaagaaa 540   
ggaaatcata tattgaagag ataacatcac tccaatattc acaatagcca ctattcacaa 600   
atgccaagat ttggaagcaa cctaagtgtc catcaacaga tgaatggata aagaaagtac 660   
tccaattata cacaatggag cacaattcag ccatgaaaaa agcatgagat cctgttatct 720   
gtaataatat ggatggaact ggaggtcatc atgttaagtg aaataagcca ggcacagaaa 780   
cacagatatt gcaagttctc acatacttgt gggatct                          817   
<210> 122
<211> 1126
<212> DNA
<213> Homo sapiens
<400> 122
cattaaaatt aacattaaat agagctacca caatatccag aaatccccat gctgggtata 60    
tacctggaag aaaggaaatc atatattgaa gagataacat cactccaata ttcacaatag 120   
ccactattca caaatgccaa gatttggaag caacctaagt gtccatcaac agatgaatgg 180   
ataaagaaag tactccaatt atacacaatg gagcacaatt cagccatgaa aaaagcatga 240   
gatcctgtta tctgtaataa tatggatgga actggaggtc atcatgttaa gtgaaataag 300   
ccaggcacag aaacacagat attgcaagtt ctcacatact tgtgggatct acaaatcaaa 360   
acaactgagc taatgtctgg gccttagtca gtgttgtacc caagtactgg gagcacagct 420   
tttaaaatac atcatgaatg ctttaataca ggaatgaata gatgagaggc acaaactggt 480   
tgggtgttct tctgatacac agtatcttcc ttgacagatt cagtacaact ctcaacaggt 540   
aagtctcttc atgttatgtt accttatgag gaattaagtg gcagaacatg atttctatta 600   
ttttcctttg cagaacaaga ccaactttat tagttgggac acagtgtggc tgcatttgag 660   
tcccaagcaa ccattagtct atagctatca ccacagagtc agaggggatg agacgcccag 720   
caatctcacc caagacaact ccaccaacat tcctggttac ccaccatgtg tacagtaccc 780   
tgctaggaac cagggtcatg aaagtaaata ataccagact gtgcccttga ggagctcacc 840   
tctgctaagg gaaacaggca tagaaactta caatggtggt agagagaaaa gaggacaata 900   
ggactgtgtg agggggatag gaggcaccca gaggaggaaa tggttacatt tgtgtgagga 960   
ggttggtaag gaaaaatttt agcagaaggg gtctgtctgg ctgggcttgg aaggatacgt 1020  
aggagtcatc tagagggcac aggtacactc caggcagagg gaatttcgtg ggtaaagatg 1080  
tgtaggtgtg gcttgtgagg atggatttca attattctag aatgaa                1126  
<210> 123
<211> 624
<212> DNA
<213> Homo sapiens
<400> 123
gattaagctt ttcatgattc ctcatagaac atgaactcaa aagaggtcag caaaggggtg 60    
tgtgcgattc tttgctattg gctgcagcta tagccctgcc tccttctcca gcacataaat 120   
ctttcagcag cttggctgaa gactgctgtg cagggcagag aagctccagg caaacagccc 180   
agcaaacagc agcactcagc taaaaggaag actcacagaa cacagttgaa gaaggaaagt 240   
ggcgatggac ctcatcccaa atttggcggt ggaaacctgg cttctcctgg ctgtcagcct 300   
ggtgctcctc tatctgtgag taactgtcca aactcctctc tttgtttcct tggacttggg 360   
gtgctaatcg ggcccctttt cccttatctg ttttgaagat caaaagagat gttcaaggag 420   
aagtagctga agtgttggac gctacaaacg catagaagtt attattatct tatgcagatc 480   
tatgaatgaa taaataagca tttctcccat ccaccttcta attttggtga ctaggagggt 540   
ttagggacag catttggtag tgggaatgat ttgattagct tagatctgac gaagactaat 600   
caatgaaaac atggcagcgg caga                                        624   
<210> 124
<211> 624
<212> DNA
<213> Homo sapiens
<400> 124
gattaagctt ttcatgattc ctcatagaac atgaactcaa aagaggtcag caaaggggtg 60    
tgtgcgattc tttgctattg gctgcagcta tagccctgcc tccttctcca gcacataaat 120   
ctttcagcag cttggctgaa gactgctgtg cagggcaggg aagctccagg taaacagccc 180   
agcaaacagc agcactcagc taaaaggaag actcacagaa cacagttgaa gaaggaaagt 240   
ggcgatggac ctcatcccaa atttggcggt ggaaacctgg cttctcctgg ctgtcagcct 300   
ggtgctcctc tatctgtgag taactgtcca aactcctctc tttgtttcct tggacttggg 360   
gtgctaatcg ggcccctttt cccttatctg ttttgaagat caaaagagat gttcaaggag 420   
aagtagctga agtgttggac gctacaaacg catagaagtt attattatct tatgcagatc 480   
tatgaatgaa taaataagca tttctcccat ccaccttcta attttggtga ctaggagggt 540   
ttagggacag catttggtag tgggaatgat ttgattagct tagatctgac gaagactaat 600   
caatgaaaac atggcagcgg caga                                        624   
<210> 125
<211> 621
<212> DNA
<213> Homo sapiens
<400> 125
gattaagctt ttcatgattc ctcatagaac atgaactcaa aagaggtcag caaaggggtg 60    
tgtgcgattc tttgctattg gctgcagcta tagccctgcc tccttctcca gcacataaat 120   
ctttcagcag cttggctgaa gactgctgtg cagggcaggg aagctccagg caaacagccc 180   
agcaaacagc agcactcagc taaaaggaag actcacagaa cacagttgaa gaaggaaagt 240   
ggcgatggac ctcatcccaa atttggcggt ggaaacctgg cttctcctgg ctgtcagcct 300   
ggtgctcctc tatctgtgag taactgtcca aactcctctc tttgtttcct tggacttggg 360   
gtgctaatcg ggcccctttt cccttatctg ttttgaagat caaaagagat gttcaagaag 420   
tagctgaagt gttggacgct acaaacgcat agaagttatt attatcttat gcagatctat 480   
gaatgaataa ataagcattt ctcccatcca ccttctaatt ttggtgacta ggagggttta 540   
gggacagcat ttggtagtgg gaatgatttg attagcttag atctgacgaa gactaatcaa 600   
tgaaaacatg gcagcggcag a                                           621   
<210> 126
<211> 465
<212> DNA
<213> Homo sapiens
<400> 126
aggaaaggac ctgatgagtg aatgcaatta ctgatgttgg agttgctgtt attatttatc 60    
gtgtacatat tacctccctc tcttgaccat tccagttcct gagtaactca ccagccctct 120   
gatctataaa gtcacaatcc ctgtgacctg atttctgttt cactttgtag atatgggacc 180   
cgtacatatg ggacttttta agagactggg aattccaggg cccacacctc tgcctttgtt 240   
gggaaatgtt ttgtcctatc gtcaggtgag ttgcttgagc ttcctctttt gcttcttatg 300   
gttgcaaaca tcagcttagt tccatcagta aaaatgcccc tccttgggag ggagttctga 360   
ggtttcacat tttcagaaat ggtgggactg ggtgcagtgg atcatgcctg taatctcagc 420   
ctctgtgagg ccaagactgg caaattgctt gagcccagga gtttg                 465   
<210> 127
<211> 33
<212> PRT
<213> Homo sapiens
<400> 127
Met Asp Leu Ile Pro Asn Leu Ala Val Glu Thr Trp Leu Leu Leu Ala  
1               5                  10                  15      
Val Ser Leu Val Leu Leu Tyr Leu Tyr Gly Thr Arg Thr Tyr Gly Thr  
20                  25                  30          
Phe                                                              
<210> 128
<211> 602
<212> DNA
<213> Homo sapiens
<400> 128
catagacaag ggtgagtcct tcagtactta gagaaaattc aagagtgact ttaaattccc 60    
cacttcaaat atattctctg ttttcttgtc tttcccttaa gacatctctg aatagcttcc 120   
ttcaactgcc agtgaaagat agtaggcctg atttcattgg acgcaactgt tttcagcccc 180   
aattagaggt agggtttatt ctatttaaaa taataatcaa cttgtatttt gtttcctctc 240   
ccagggtctc tggaaatttg acacagagtg ctataaaaag tatggaaaaa tgtgggggtg 300   
agtattctga aaacctccat tggatagacc tgctactgtg aggaggttac cccactgcag 360   
gatagtctct gcccaggtct tcatgggatg aagctcttgt caacctaaat acaaacagag 420   
agaggttctc tgaaagaaga ggataattac ttgggagtag aatattgcaa tgggaatctg 480   
cttgccgtta taaactatgt gcaaattcag ggaggtaaac aagacaaaga tgctccatag 540   
aaaatatgag aagaatctca taactgtttt gagataatta ttgttagcta caaagatcaa 600   
ta                                                                602   
<210> 129
<211> 594
<212> DNA
<213> Homo sapiens
<400> 129
cagtatctct tccctgtttg gaccacatta cccttcatca tatgaagcct tgggtggctc 60    
ctgtgtgaga ctcttgctgt gtgtcacacc ctaatgaact agaacctaag gttgctgtgt 120   
gtcgtacaac taggggtatg gattacataa cataatgatc aaagtctggc ttcctgggtg 180   
tggctccagc tgcagaatag ggctagtgaa gtttaatcag ctccgttgtc cccacacaga 240   
acgtatgaag gtcaactccc tgtgctggcc atcacagatc ccgacgtgat cagaacagtg 300   
ctagtgaaag aatgttattc tgtcttcaca aatcgaaggg taagcatcca ttttttgaaa 360   
tttaaataat gattgatcca ctgattaaat ttttattttg aaaaaaacat atattcacag 420   
aaggttacct aaaaaatgta caggaaggtt ccatgtactc ttcatcctgt cccgcccagt 480   
ggtaacatct tgcaatcttg tatattgcaa tatatatcta gtatattcat attatcaggt 540   
tggcacaaaa gttaaaatgg caaactacag gctgggcata atggctcatg cctg       594   
<210> 130
<211> 594
<212> DNA
<213> Homo sapiens
<400> 130
cagtatctct tccctgtttg gaccacatta cccttcatca tatgaagcct tgggtggctc 60    
ctgtgtgaga ctcttgctgt gtgtcacacc ctaatgaact agaacctaag gttgctgtgt 120   
gtcgtacaac taggggtatg gattacataa cataatgatc aaagtctggc ttcctgggtg 180   
tggctccagc tgcagaatcg ggctagtgaa gtttaatcag ctctgttgtc cccacacaga 240   
acgtatgaag gtcaactccc tgtgctggcc atcacagatc ccgacgtgat cagaacagtg 300   
ctagtgaaag aatgttattc tgtcttcaca aatcgaaggg taagcatcca ttttttgaaa 360   
tttaaataat gattgatcca ctgattaaat ttttattttg aaaaaaacat atattcacag 420   
aaggttacct aaaaaatgta caggaaggtt ccatgtactc ttcatcctgt cccgcccagt 480   
ggtaacatct tgcaatcttg tatattgcaa tatatatcta gtatattcat attatcaggt 540   
tggcacaaaa gttaaaatgg caaactacag gctgggcata atggctcatg cctg       594   
<210> 131
<211> 594
<212> DNA
<213> Homo sapiens
<400> 131
cagtatctct tccctgtttg gaccacatta cccttcatca tatgaagcct tgggtggctc 60    
ctgtgtgaga ctcttgctgt gtgtcacacc ctaatgaact agaacctaag gttgctgtgt 120   
gtcgtacaac taggggtatg gattacataa cataatgatc aaagtctggc ttcctgggtg 180   
tggctccagc tgcagaatcg ggctagtgaa gtttaatcag ctccgttgtc cccacacaga 240   
acgtatgaag gtcaactccc tgtgctggcc atcacagatc ccgacgtgat cagaacagtg 300   
ctagtgaaag aatgttatta tgtcttcaca aatcgaaggg taagcatcca ttttttgaaa 360   
tttaaataat gattgatcca ctgattaaat ttttattttg aaaaaaacat atattcacag 420   
aaggttacct aaaaaatgta caggaaggtt ccatgtactc ttcatcctgt cccgcccagt 480   
ggtaacatct tgcaatcttg tatattgcaa tatatatcta gtatattcat attatcaggt 540   
tggcacaaaa gttaaaatgg caaactacag gctgggcata atggctcatg cctg       594   
<210> 132
<211> 60
<212> PRT
<213> Homo sapiens
<400> 132
Met Trp Gly Thr Tyr Glu Gly Gln Leu Pro Val Leu Ala Ile Thr Asp  
1               5                  10                  15      
Pro Asp Val Ile Arg Thr Val Leu Val Lys Glu Cys Tyr Tyr Val Phe  
20                  25                  30          
Thr Asn Arg Arg Ser Leu Gly Pro Val Gly Phe Met Lys Ser Ala Ile  
35                  40                  45              
Ser Leu Ala Glu Asp Glu Glu Trp Lys Arg Ile Arg                  
50                  55                  60                  
<210> 133
<211> 601
<212> DNA
<213> Homo sapiens
<400> 133
cagtatctct tccctgtttg gaccacatta cccttcatca tatgaagcct tgggtggctc 60    
ctgtgtgaga ctcttgctgt gtgtcacacc ctaatgaact agaacctaag gttgctgtgt 120   
gtcgtacaac taggggtatg gattacataa cataatgatc aaagtctggc ttcctgggtg 180   
tggctccagc tgcagaatcg ggctagtgaa gtttaatcag ctccgttgtc cccacacaga 240   
acgtatgaag gtcaactccc tgtgctggcc atcacagatc ccgacgtgat cagaacagtg 300   
ctagtgaaag aatgttattc tgtcttcaca aatcgaaggg taagcatcca ttttttgaaa 360   
tttaaataat gattgatcca ctgattaaat ttttattttg aaaaaaacat atattcacag 420   
aaggttacct aaaaaatgta cctaaaaaat gaaggttcca tgtactcttc atcctgtccc 480   
gcccagtggt aacatcttgc aatcttgtat attgcaatat atatctagta tattcatatt 540   
atcaggttgg cacaaaagtt aaaatggcaa actacaggct gggcataatg gctcatgcct 600   
g                                                                 601   
<210> 134
<211> 603
<212> DNA
<213> Homo sapiens
<400> 134
agcggaaaac tcaaggaggt atgaaaataa gatgagtctt aattagaaat gtaaagaatg 60    
aatctgggga caggtagaaa gtaagatcac agtccgtttc caaggggtag tccactgagt 120   
tcgagcttcc taaaaatggt ctttgatctt tatgtacaga aaagacatca caaaattcat 180   
tacaaaatgt cacttactgc tccatgctgg agaaagccat atccttctgg gacttgagtc 240   
tgcacattta actacaggta ctgatctgtt ttgtgcttag atgttcccca tcattgccca 300   
gtatggagat gtattggtga gaaacttgag gcgggaagca gagaaaggca agcctgtcac 360   
cttgaaagag taagtaggag cacagccatg gggttctgag ctgtcatgag cccttccagc 420   
tgcctgccat ggagtcgaca gtcgcactgt tgggttactc cagtgaccag acaaaagcag 480   
ggcagcgctg caactccaaa gagccaccta agagggagtg gctcccatga ggcggcaagt 540   
cagcaaggga aaagggcctt ctctcctgtg cacaggagcc aggatttact tatctgttaa 600   
ctt                                                               603   
<210> 135
<211> 603
<212> DNA
<213> Homo sapiens
<400> 135
agcggaaaac tcaaggaggt atgaaaataa gatgagtctt aattagaaat gtaaagaatg 60    
aatctgggga caggtagaaa gtaagatcac agtccgtttc caaggggtag tccactgagt 120   
tcgagcttcc taaaaatggt cttttatctt tatgtacaga aaagacatca caaaattcat 180   
tacaaaatgt cacttactgc tccatgctgg agaaagccat atccttctgg gacttgagtc 240   
cgcacattta actacaggta ctgatctgtt ttgtgcttag atgttcccca tcattgccca 300   
gtatggagat gtattggtga gaaacttgag gcgggaagca gagaaaggca agcctgtcac 360   
cttgaaagag taagtaggag cacagccatg gggttctgag ctgtcatgag cccttccagc 420   
tgcctgccat ggagtcgaca gtcgcactgt tgggttactc cagtgaccag acaaaagcag 480   
ggcagcgctg caactccaaa gagccaccta agagggagtg gctcccatga ggcggcaagt 540   
cagcaaggga aaagggcctt ctctcctgtg cacaggagcc aggatttact tatctgttaa 600   
ctt                                                               603   
<210> 136
<211> 626
<212> DNA
<213> Homo sapiens
<400> 136
attggacatg atagctagat ttgtttcagg aaaacatcct gctttccaag gatttagatg 60    
aatgtttttg ttcactggtg actcaggtaa cacgtcttca agaagccata gggaggttga 120   
gggagggaag tcgtcaagaa gggaggttga ggactgcact tttgatttac ttctgacttc 180   
acgagtcact ttctgccaaa gaaatctctc cttttgcttc tagcaccgac tagatttcct 240   
tcagctgatg attgactccc agaattcgaa agaaactgag tcccacaaag gtaaccaagg 300   
agtgcttctg agggctactg gcggggacac taagagggag ggccttgttc tgaaaatgtg 360   
caggaagtat tccaggaaga tgagaatttt tgccacatag cagaacaaca cacatttaga 420   
tgttataaat ggtagctgga ggcactttcc agaagcccac aggtatagcc atgttccagg 480   
ctgaaagggc aaccctaagc aaacctagaa tgcttggagg acagtcagtg gtttgtggat 540   
cacctacatg agatcaaatg ccagttctca gcctcctcca gatccaccaa gtgagaacct 600   
ctacttggaa atttatatca aacata                                      626   
<210> 137
<211> 623
<212> DNA
<213> Homo sapiens
<400> 137
attggacatg atagctagat ttgtttcagg aaaacatcct gctttccaag gatttagatg 60    
aatgtttttg ttcactggtg actcaggtaa cacgtcttca agaagccata gggaggttga 120   
gggagggaag tcaagaaggg aggttgagga ctgcactttt gatttacttc tgacttcacg 180   
agtcactttc tgccaaagaa atctctcctt ttgcttctag caccgactag atttccttca 240   
gctgatgatt gactcccaga attcgaaaga aactgagtcc cacaaaggta accaaggagt 300   
gcttctgagg gctactggcg gggacactaa gagggagggc cttgttctga aaatgtgcag 360   
gaattattcc aggaagatga gaatttttgc cacatagcag aacaacacac atttagatgt 420   
tataaatggt agctggaggc actttccaga agcccacagg tatagccatg ttccaggctg 480   
aaagggcaac cctaagcaaa cctagaatgc ttggaggaca gtcagtggtt tgtggatcac 540   
ctacatgaga tcaaatgcca gttctcagcc tcctccagat ccaccaagtg agaacctcta 600   
cttggaaatt tatatcaaac ata                                         623   
<210> 138
<211> 826
<212> DNA
<213> Homo sapiens
<400> 138
agataaagta cttttaggat cattcaaggc acacacccat aacactgagt atgtaagaca 60    
gaaatgctct ctctggaaat tacagcagtg ctggtgctgg gatgccatga tgaggagtgt 120   
gtggcccaca atcatgtaga ccttgggaaa acctggatta aaatgatttt gcgtcatcct 180   
ggccctgtat aagatacata tcagaatgaa aaccactccc agtgtgactt tgaattgctt 240   
ttccattttt tcttcttggg attagagaac ttcacttaga tttcatctaa gctgtgatgt 300   
tgtacgttga cctgatttac ctaaaatgtc tttcctctcc tttcagctct gtctgatctg 360   
gagctcgcag cccagtcaat aatcttcatt tttgctggct atgaaaccac cagcagtgtt 420   
ctttccttca ctttatatga actggccact caccctgatg tccagcagaa actgcaaaag 480   
gagattgatg cagttttgcc caataaggtg aggggatgac ccctggagat gaagggaaga 540   
ggtgaagcct tagcaaaaat gcctcctcac cactccccag gagaattttt ataaaaagca 600   
taatcactga ttccttcact gacataatgt aggaagcctc tgaggagaaa aacaaaggga 660   
gaaacataga gaacggttgc tactggcaga agcataagat ctttgtacaa tattgctggc 720   
cctggttcac ctgtttactg ttatcacaat aatgctaagt aaaaaaaaaa aaaaaaaaaa 780   
aaaaaaaaaa aggagtgtgg cgagaagatg gccaaacagg aacagc                826   
<210> 139
<211> 795
<212> DNA
<213> Homo sapiens
<400> 139
gtccctgggg tgaggatggt cttgaatatc tcctacattc ataactcctc cacacatctc 60    
agtaggtcac tgagcacatc aatggacatg ccagttatta aaatacttca cgaatactat 120   
gatcatttac cagtatgagt tattctctgg agcttctaat acttcagtag tactgcatgg 180   
actcagttga gagttaattc aaaatctcag attatccaat tctgtttctt tccttccagg 240   
caccacctac ctatgatgcc gtggtacaga tggagtacct tgacatggtg gtgaatgaaa 300   
cactcagatt attcccagtt gctattagac ttgagaggac ttgcaagaaa gatgttgaaa 360   
tcaatggggt attcattccc aaagggtcaa tggtggtgat tccaacttat gctcttcacc 420   
atgacccaaa gtactggaca gagcctgagg agttccgccc tgaaaggtac aagtctccag 480   
ggaaatggag ctcaccctga cccaggctgg ttcaagcata ttctgcctct cttaatctac 540   
atgacaatcg tgtggttgta caatcatttg cttgtaagtc tttttatcac aaaaaagtga 600   
taattatcaa actttacaaa ccacagacta gaaaaaacga aactacatcc atccacagtc 660   
ccagcacaag acaaagataa tcaattatgt ccctgtgggc atttttctac gcctatatag 720   
atttttaaaa attagaatgg tatcactttt tatttggttt gaattgctgc ttacttgatt 780   
taacaggaaa ctatc                                                  795   
<210> 140
<211> 796
<212> DNA
<213> Homo sapiens
<400> 140
gtccctgggg tgaggatggt cttgaatatc tcctacattc ataactcctc cacacatctc 60    
agtaggtcac tgagcacatc aatggacatg ccagttatta aaatacttca cgaatactat 120   
gatcatttac cagtatgagt tattctctgg agcttctaat acttcaatag tactgcatgg 180   
actcagttga gagttaattc aaaatctcag attatccaat tctgtttctt tccttccagg 240   
caccacctta cctatgatgc cgtggtacag atggagtacc ttgacatggt ggtgaatgaa 300   
acactcagat tattcccagt tgctattaga cttgagagga cttgcaagaa agatgttgaa 360   
atcaatgggg tattcattcc caaagggtca atggtggtga ttccaactta tgctcttcac 420   
catgacccaa agtactggac agagcctgag gagttccgcc ctgaaaggta caagtctcca 480   
gggaaatgga gctcaccctg acccaggctg gttcaagcat attctgcctc tcttaatcta 540   
catgacaatc gtgtggttgt acaatcattt gcttgtaagt ctttttatca caaaaaagtg 600   
ataattatca aactttacaa accacagact agaaaaaacg aaactacatc catccacagt 660   
cccagcacaa gacaaagata atcaattatg tccctgtggg catttttcta cgcctatata 720   
gatttttaaa aattagaatg gtatcacttt ttatttggtt tgaattgctg cttacttgat 780   
ttaacaggaa actatc                                                 796   
<210> 141
<211> 59
<212> PRT
<213> Homo sapiens
<400> 141
Ala Leu Ser Asp Leu Glu Leu Ala Ala Gln Ser Ile Ile Phe Ile Phe  
1               5                  10                  15      
Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Thr Leu Tyr Glu  
20                  25                  30          
Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Lys Glu Ile Asp  
35                  40                  45              
Ala Val Leu Pro Asn Lys Ala Pro Pro Tyr Leu                      
50                  55                                      
<210> 142
<211> 795
<212> DNA
<213> Homo sapiens
<400> 142
gtccctgggg tgaggatggt cttgaatatc tcctacattc ataactcctc cacacatctc 60    
agtaggtcac tgagcacatc aatggacatg ccagttatta aaatacttca cgaatactat 120   
gatcatttac cagtatgagt tattctctgg agcttctaat acttcaatag tactgcatgg 180   
actcagttga gagttaattc aaaatctcag attatccaat tctgtttctt tccttccagg 240   
caccacctac ctatgatgcc gtggtacaga tggagtacct tgacatggtg gtgaatgaaa 300   
cactcagatt attcccagtt gctattagac ttgagaggac ttgcaagaaa gatgttgaaa 360   
tcaatggggt attcattccc aaagggtcaa tggtggtgat tccaacttat gctcttcacc 420   
atgacccaaa gtactggaca gagcctgagg agttccgccc tgaaaggtac aagtctccag 480   
ggaaatggag ctcaccctga cccaggctgg ttcaagcata ttctgcctct cttaatctac 540   
atgacaatcg tgtggttgta caatcatttg cttgtaagtc tttttatcac aaaaaagtga 600   
taattatcaa actttacaaa ccacagacta gaaaaaacga aattacatcc atccacagtc 660   
ccagcacaag acaaagataa tcaattatgt ccctgtgggc atttttctac gcctatatag 720   
atttttaaaa attagaatgg tatcactttt tatttggttt gaattgctgc ttacttgatt 780   
taacaggaaa ctatc                                                  795   
<210> 143
<211> 616
<212> DNA
<213> Homo sapiens
<400> 143
caggcctggc acagagtcag tgctccataa atattttgtt aaacgatgga tggtgagtgc 60    
ttttactatc cagtatttac ccagcttata gattaagtat gaagagttca agatacatgg 120   
tgttaagagt cgtttttata tgcttgcaaa gcatttttgt catatttttt ctactttgct 180   
tccatctttt cttctttcac ttcatttatt aattctccat atgcttgttt aactattgta 240   
gatccccttg aaattagaca cgcaaggact tcttcaacca gaaaaaccca ttgttctaaa 300   
ggtggattca agagatggaa ccctaagtgg agaatgagtt attctaagga cttctacttt 360   
ggtcttcaag aaagctgtgc cccagaacac cagagatttc aacttagtca ataaaacctt 420   
gaaataaaga tgggcttaat ctaatgtact gcatgagtag ttggtgattt tgtacattca 480   
ttgagctctc ccagagtctg tgtagagtgt tgtgcattat gtagtataaa ggaggtgacc 540   
aggtaagtga cagataggta gactcagctt ctctgcttct cataggacta cctctaccca 600   
cctctagtta gcatta                                                 616   
<210> 144
<211> 1508
<212> DNA
<213> Homo sapiens
<400> 144
ccatggctct gttattagca gtttttctgg tgctcctcta tctatatggg acccgtacac 60    
atggactttt taagagactg ggaattccag ggcccacacc tctgcctttg ttgggaaatg 120   
ttttgtccta tcgtcagggt ctctggaaat ttgacacaga gtgctataaa aagtatggaa 180   
aaatgtgggg aacgtatgaa ggtcaactcc ctgtgctggc catcacagat cccgacgtga 240   
tcagaacagt gctagtgaaa gaatgttatt ctgtcttcac aaatcgaagg tctttaggcc 300   
cagtgggatt tatgaaaagt gccatctctt tagctgagga tgaagaatgg aagagaatac 360   
ggtcattgct gtctccaacc ttcaccagcg gaaaactcaa ggagatgttc cccatcattg 420   
cccagtatgg agatgtattg gtgagaaact tgaggcggga agcagagaaa ggcaagcctg 480   
tcaccttgaa agacatcttt ggggcctaca gcatggatgt gattactggc acatcatttg 540   
gagtgaacat cgactctctc aacaatccac aagacccctt tgtggagagc actaagaagt 600   
tcctaaaatt tggtttctta gatccattat ttctctcaat aatactcttt ccattcctta 660   
ccccagtttt tgaagcatta aatgtctctc tgtttccaaa agataccata aattttttaa 720   
gtaaatctgt aaacagaatg aagaaaagtc gcctcaacga caaacaaaag caccgactag 780   
atttccttca gctgatgatt gactcccaga attcgaaaga aactgagtcc cacaaagctc 840   
tgtctgatct ggagctcgca gcccagtcaa taatcttcat ttttgctggc tatgaaacca 900   
ccagcagtgt tctttccttc actttatatg aactggccac tcaccctgat gtccagcaga 960   
aactgcaaaa ggagattgat gcagttttgc ccaataaggc accacctacc tatgatgccg 1020  
tggtacagat ggagtacctt gacatggtgg tgaatgaaac actcagatta ttcccagttg 1080  
ctattagact tgagaggact tgcaagaaag atgttgaaat caatggggta ttcattccca 1140  
aagggtcaat ggtggtgatt ccaacttatg ctcttcacca tgacccaaag tactggacag 1200  
agcctgagga gttccgccct gaaaggttca gtaagaagaa ggacagcata gatccttaca 1260  
tatacacacc ctttggaact ggacccagaa actgcattgg catgaggttt gctctcatga 1320  
acatgaaact tgctctaatc agagtccttc agaacttctc cttcaaacct tgtaaagaaa 1380  
cacagatccc cttgaaatta gacacgcaag gacttcttca accagaaaaa cccattgttc 1440  
taaaggtgga ttcaagagat ggaaccctaa gtggagaaca tcaccatcac catcactgag 1500  
atctgcag                                                          1508  
<210> 145
<211> 60
<212> PRT
<213> Homo sapiens
<400> 145
Pro Val Ala Ile Arg Leu Glu Arg Thr Cys Lys Lys Asp Val Glu Ile  
1               5                  10                  15      
Asn Gly Val Phe Ile Pro Lys Gly Ser Met Val Val Ile Pro Asn Tyr  
20                  25                  30          
Ala Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Glu Phe Arg  
35                  40                  45              
Pro Glu Arg Phe Ser Lys Lys Lys Asp Ser Ile Asp                  
50                  55                  60                  
<210> 146
<211> 11
<212> DNA
<213> Homo sapiens
<400> 146
tttcagtatc t                                                      11    
<210> 147
<211> 11
<212> DNA
<213> Homo sapiens
<400> 147
tttcaatatc t                                                      11    
<210> 148
<211> 11
<212> DNA
<213> Homo sapiens
<400> 148
tttaatagaa g                                                      11    
<210> 149
<211> 11
<212> DNA
<213> Homo sapiens
<400> 149
tttaacagaa g                                                      11    
<210> 150
<211> 11
<212> DNA
<213> Homo sapiens
<400> 150
attccccata g                                                      11    
<210> 151
<211> 11
<212> DNA
<213> Homo sapiens
<400> 151
attcctcata g                                                      11    
<210> 152
<211> 11
<212> DNA
<213> Homo sapiens
<400> 152
tagaatatga a                                                      11    
<210> 153
<211> 11
<212> DNA
<213> Homo sapiens
<400> 153
tagaacatga a                                                      11    
<210> 154
<211> 11
<212> DNA
<213> Homo sapiens
<400> 154
gtaacttatc c                                                      11    
<210> 155
<211> 11
<212> DNA
<213> Homo sapiens
<400> 155
gtaacgtatc c                                                      11    
<210> 156
<211> 11
<212> DNA
<213> Homo sapiens
<400> 156
ttcacgtgga g                                                      11    
<210> 157
<211> 11
<212> DNA
<213> Homo sapiens
<400> 157
ttcacatgga g                                                      11    
<210> 158
<211> 11
<212> DNA
<213> Homo sapiens
<400> 158
tggacgcaac t                                                      11    
<210> 159
<211> 11
<212> DNA
<213> Homo sapiens
<400> 159
tggacacaac t                                                      11    
<210> 160
<211> 11
<212> DNA
<213> Homo sapiens
<400> 160
gaggataatt a                                                      11    
<210> 161
<211> 11
<212> DNA
<213> Homo sapiens
<400> 161
gaggaaaatt a                                                      11    
<210> 162
<211> 11
<212> DNA
<213> Homo sapiens
<400> 162
catcattgcc c                                                      11    
<210> 163
<211> 11
<212> DNA
<213> Homo sapiens
<400> 163
catcactgcc c                                                      11    
<210> 164
<211> 11
<212> DNA
<213> Homo sapiens
<400> 164
cagtcgcact g                                                      11    
<210> 165
<211> 11
<212> DNA
<213> Homo sapiens
<400> 165
cagtcacact g                                                      11    
<210> 166
<211> 11
<212> DNA
<213> Homo sapiens
<400> 166
actaagaagt t                                                      11    
<210> 167
<211> 11
<212> DNA
<213> Homo sapiens
<400> 167
actaaaaagt t                                                      11    
<210> 168
<211> 11
<212> DNA
<213> Homo sapiens
<400> 168
gatccattat t                                                      11    
<210> 169
<211> 11
<212> DNA
<213> Homo sapiens
<400> 169
gatccgttat t                                                      11    
<210> 170
<211> 11
<212> DNA
<213> Homo sapiens
<400> 170
caattccatt g                                                      11    
<210> 171
<211> 11
<212> DNA
<213> Homo sapiens
<400> 171
caatttcatt g                                                      11    
<210> 172
<211> 11
<212> DNA
<213> Homo sapiens
<400> 172
tgtcaatcta g                                                      11    
<210> 173
<211> 11
<212> DNA
<213> Homo sapiens
<400> 173
tgtcagtcta g                                                      11    
<210> 174
<211> 11
<212> DNA
<213> Homo sapiens
<400> 174
ttgtttgttt t                                                      11    
<210> 175
<211> 11
<212> DNA
<213> Homo sapiens
<400> 175
ttgttcgttt t                                                      11    
<210> 176
<211> 11
<212> DNA
<213> Homo sapiens
<400> 176
aaataaagaa g                                                      11    
<210> 177
<211> 11
<212> DNA
<213> Homo sapiens
<400> 177
aaatacagaa g                                                      11    
<210> 178
<211> 11
<212> DNA
<213> Homo sapiens
<400> 178
tttgcgtcat c                                                      11    
<210> 179
<211> 11
<212> DNA
<213> Homo sapiens
<400> 179
tttgcatcat c                                                      11    
<210> 180
<211> 11
<212> DNA
<213> Homo sapiens
<400> 180
ttgacctgat t                                                      11    
<210> 181
<211> 11
<212> DNA
<213> Homo sapiens
<400> 181
ttgacttgat t                                                      11    
<210> 182
<211> 11
<212> DNA
<213> Homo sapiens
<400> 182
tattgtagat c                                                      11    
<210> 183
<211> 11
<212> DNA
<213> Homo sapiens
<400> 183
tattgcagat c                                                      11    
<210> 184
<211> 11
<212> DNA
<213> Homo sapiens
<400> 184
ccttttccct t                                                      11    
<210> 185
<211> 11
<212> DNA
<213> Homo sapiens
<400> 185
cctttcccct t                                                      11    
<210> 186
<211> 11
<212> DNA
<213> Homo sapiens
<400> 186
cttatgcaga t                                                      11    
<210> 187
<211> 11
<212> DNA
<213> Homo sapiens
<400> 187
cttatacaga t                                                      11    
<210> 188
<211> 11
<212> DNA
<213> Homo sapiens
<400> 188
aatacggtca t                                                      11    
<210> 189
<211> 11
<212> DNA
<213> Homo sapiens
<400> 189
aatacagtca t                                                      11    
<210> 190
<211> 11
<212> DNA
<213> Homo sapiens
<400> 190
ggaggtatga a                                                      11    
<210> 191
<211> 11
<212> DNA
<213> Homo sapiens
<400> 191
ggaggcatga a                                                      11    
<210> 192
<211> 11
<212> DNA
<213> Homo sapiens
<400> 192
agtccgtttc c                                                      11    
<210> 193
<211> 11
<212> DNA
<213> Homo sapiens
<400> 193
agtccatttc c                                                      11    
<210> 194
<211> 11
<212> DNA
<213> Homo sapiens
<400> 194
tctgccaaag a                                                      11    
<210> 195
<211> 11
<212> DNA
<213> Homo sapiens
<400> 195
tctgcgaaag a                                                      11    
<210> 196
<211> 11
<212> DNA
<213> Homo sapiens
<400> 196
acccattgtt c                                                      11    
<210> 197
<211> 11
<212> DNA
<213> Homo sapiens
<400> 197
acccactgtt c                                                      11    
<210> 198
<211> 11
<212> DNA
<213> Homo sapiens
<400> 198
gctactggct g                                                      11    
<210> 199
<211> 11
<212> DNA
<213> Homo sapiens
<400> 199
gctaccggct g                                                      11    
<210> 200
<211> 11
<212> DNA
<213> Homo sapiens
<400> 200
gaaatcaccc g                                                      11    
<210> 201
<211> 11
<212> DNA
<213> Homo sapiens
<400> 201
gaaattaccc g                                                      11    
<210> 202
<211> 33
<212> DNA
<213> Homo sapiens
<400> 202
gctctactgt catttctaac cataatctct tta                              33    
<210> 203
<211> 27
<212> DNA
<213> Homo sapiens
<400> 203
gcttcatatg atgaagggta atgtggt                                     27    
<210> 204
<211> 18
<212> DNA
<213> Homo sapiens
<400> 204
tgtctttcag tatctctt                                               18    
<210> 205
<211> 19
<212> DNA
<213> Homo sapiens
<400> 205
tgtctttcaa tatctcttc                                              19    
<210> 206
<211> 444
<212> DNA
<213> Homo sapiens
<400> 206
catttagtcc ttgtgagcac ttgatgattt acctgccttc aatttttcac tgacctaata 60    
ttctttttga taatgaagta ttttaaacat ataaaacatt atggagagtg gcataggaga 120   
tacccacgta tgtaccaccc agcttaacga atgctctact gtcatttcta accataatct 180   
ctttaaagag ctcttttgtc tttcaatatc tcttccctgt ttggaccaca ttacccttca 240   
tcatatgaag ccttgggtgg ctcctgtgtg agactcttgc tgtgtgtcac accctaatga 300   
actagaacct aaggttgctg tgtgtcgtac aactaggggt atggattaca taacataatg 360   
atcaaagtct ggcttcctgg gtgtggctcc agctgcagaa tcgggctagt gaagtttaat 420   
cagctccgtt gtccccacac agaa                                        444   
<210> 207
<211> 830
<212> DNA
<213> Homo sapiens
<400> 207
tggtcaccca ccatgtgtac agtaccctgc tagggtccag ggtcatgaaa gtaaataata 60    
ccagactgtg cccttgagga actcacctct gctaagggaa acaggcacag aaacccacaa 120   
gggtggtaga gaggaaatag gacaatagga ctgtgtgagg gggataggag gcacccagag 180   
gaggaaatgg ttacatctgt gtgaggaggt tggtaaggaa agactttaac agaaggggtc 240   
tgtctggctg ggcttgcaag gatgtgtagg agtcatctag ggggcacaag tacactccag 300   
gcagagggaa ttgcatgggt aaagatctgc agttgtggct tgtggggatg gatttcaagt 360   
attctggaat gaagacagcc atggaaacaa gggcaggtga gaggatattt aagaggcttc 420   
atgccaatgg ctccacttca gtttctgata agaactcagg ttccgtggac tccctgataa 480   
aactgattaa gttgtttatg attccccata gaatatgaac tcaaaggagg taagcaaagg 540   
ggtgtgtgcg attctttgct actggctgca gctgcagccc cacctccttc tccagcacat 600   
aaacatttca gcagcttgac ctaagactgc tgtgcagggc agggatgctc caggcagaca 660   
gcccagcaaa caacagcaca cagctgaaag taagactcag aggagacagt tgaagaaggc 720   
aagtggcgat ggacctcatc ccaaatttgg cggtggaaac ctggcttctc ctggctgtca 780   
gcctggtgct cctctatctg tcagtaactg tccagattcc tctcctctgt            830   
<210> 208
<211> 830
<212> DNA
<213> Homo sapiens
<400> 208
tggtcaccca ccatgtgtac agtaccctgc tagggtccag ggtcatgaaa gtaaataata 60    
ccagactgtg cccttgagga actcacctct gctaagggaa acaggcacag aaacccacaa 120   
gggtggtaga gaggaaatag gacaatagga ctgtgtgagg gggataggag gcacccagag 180   
gaggaaatgg ttacatctgt gtgaggaggt tggtaaggaa agactttaat agaaggggtc 240   
tgtctggctg ggcttgcaag gatgtgtagg agtcatctag ggggcacaag tacactccag 300   
gcagagggaa ttgcatgggt aaagatctgc agttgtggct tgtggggatg gatttcaagt 360   
attctggaat gaagacagcc atggaaacaa gggcaggtga gaggatattt aagaggcttc 420   
atgccaatgg ctccacttca gtttctgata agaactcagg ttccgtggac tccctgataa 480   
aactgattaa gttgtttatg attcctcata gaatatgaac tcaaaggagg taagcaaagg 540   
ggtgtgtgcg attctttgct actggctgca gctgcagccc cacctccttc tccagcacat 600   
aaacatttca gcagcttgac ctaagactgc tgtgcagggc agggatgctc caggcagaca 660   
gcccagcaaa caacagcaca cagctgaaag taagactcag aggagacagt tgaagaaggc 720   
aagtggcgat ggacctcatc ccaaatttgg cggtggaaac ctggcttctc ctggctgtca 780   
gcctggtgct cctctatctg tcagtaactg tccagattcc tctcctctgt            830   
<210> 209
<211> 830
<212> DNA
<213> Homo sapiens
<400> 209
tggtcaccca ccatgtgtac agtaccctgc tagggtccag ggtcatgaaa gtaaataata 60    
ccagactgtg cccttgagga actcacctct gctaagggaa acaggcacag aaacccacaa 120   
gggtggtaga gaggaaatag gacaatagga ctgtgtgagg gggataggag gcacccagag 180   
gaggaaatgg ttacatctgt gtgaggaggt tggtaaggaa agactttaat agaaggggtc 240   
tgtctggctg ggcttgcaag gatgtgtagg agtcatctag ggggcacaag tacactccag 300   
gcagagggaa ttgcatgggt aaagatctgc agttgtggct tgtggggatg gatttcaagt 360   
attctggaat gaagacagcc atggaaacaa gggcaggtga gaggatattt aagaggcttc 420   
atgccaatgg ctccacttca gtttctgata agaactcagg ttccgtggac tccctgataa 480   
aactgattaa gttgtttatg attccccata gaacatgaac tcaaaggagg taagcaaagg 540   
ggtgtgtgcg attctttgct actggctgca gctgcagccc cacctccttc tccagcacat 600   
aaacatttca gcagcttgac ctaagactgc tgtgcagggc agggatgctc caggcagaca 660   
gcccagcaaa caacagcaca cagctgaaag taagactcag aggagacagt tgaagaaggc 720   
aagtggcgat ggacctcatc ccaaatttgg cggtggaaac ctggcttctc ctggctgtca 780   
gcctggtgct cctctatctg tcagtaactg tccagattcc tctcctctgt            830   
<210> 210
<211> 837
<212> DNA
<213> Homo sapiens
<400> 210
caaaaattag ctaggtgtgg tggtatgcac ctataatctc agctacccag gaggctgagg 60    
caggagaatc acttgaacct ggaggcagag gttgcagtga gccgagacgc accattacac 120   
tccagcctgg gtgacagagt gagattccat ctcaaaaaaa aaaaaaaaaa attatgcctt 180   
tttgaagcac atacatttta taacatacaa ctgaatccct tattatatta ttagttttga 240   
tttaatgttt tcaaaccatc tcccctgata tttctgggag atgggaaaca tgttttctta 300   
cacctcttgc attccattct caactcccaa ctgtcttact gcaatgaaca cttaataaga 360   
aacagtcaat tggtcaattg attgggcaac aggctaaaca cactcattcc ttgtctgttc 420   
ccacttcttt ctttactttc ccttcctgag taacgtatcc taaagtcatt aggtgggtgg 480   
cagccagatg gtggccacac attaaggtag aaaagagagt gtcatgatgg ttccaagtca 540   
gagacctagt agggtgagga tcaagtaggt gttcacgtgg agaaacagcc cggcctgtgt 600   
gtgggagtcc aagcaagcag agaaaatgtc gacacagagg ggtggcctga aaaagcagcc 660   
agagcctaaa cagggcatgg agaacatatt tagggcatga ggtgaggagg gcatccatga 720   
gtgggaaggg atgggtgagg tttcactaca taaaggggat tgatgaaata agtaaataaa 780   
gtatactgga agccaggtgt gtcacttttg cagaaaagag tcatggattc agaaagg    837   
<210> 211
<211> 837
<212> DNA
<213> Homo sapiens
<400> 211
caaaaattag ctaggtgtgg tggtatgcac ctataatctc agctacccag gaggctgagg 60    
caggagaatc acttgaacct ggaggcagag gttgcagtga gccgagacgc accattacac 120   
tccagcctgg gtgacagagt gagattccat ctcaaaaaaa aaaaaaaaaa attatgcctt 180   
tttgaagcac atacatttta taacatacaa ctgaatccct tattatatta ttagttttga 240   
tttaatgttt tcaaaccatc tcccctgata tttctgggag atgggaaaca tgttttctta 300   
cacctcttgc attccattct caactcccaa ctgtcttact gcaatgaaca cttaataaga 360   
aacagtcaat tggtcaattg attgggcaac aggctaaaca cactcattcc ttgtctgttc 420   
ccacttcttt ctttactttc ccttcctgag taacttatcc taaagtcatt aggtgggtgg 480   
cagccagatg gtggccacac attaaggtag aaaagagagt gtcatgatgg ttccaagtca 540   
gagacctagt agggtgagga tcaagtaggt gttcacatgg agaaacagcc cggcctgtgt 600   
gtgggagtcc aagcaagcag agaaaatgtc gacacagagg ggtggcctga aaaagcagcc 660   
agagcctaaa cagggcatgg agaacatatt tagggcatga ggtgaggagg gcatccatga 720   
gtgggaaggg atgggtgagg tttcactaca taaaggggat tgatgaaata agtaaataaa 780   
gtatactgga agccaggtgt gtcacttttg cagaaaagag tcatggattc agaaagg    837   
<210> 212
<211> 602
<212> DNA
<213> Homo sapiens
<400> 212
catagacaag ggtgagtcct tcagtactta gagaaaattc aagagtgact ttaaattccc 60    
cacttcaaat atattctctg ttttcttgtc tttcccttaa gacatctctg aatagcttcc 120   
ttcaactgcc agtgaaagat agcaggcctg atttcattgg acacaactgt tttcagcccc 180   
aattagaggt agggtttatt ctatttaaaa taataatcaa cttgtatttt gtttcctctc 240   
ccagggtctc tggaaatttg acacagagtg ctataaaaag tatggaaaaa tgtgggggtg 300   
agtattctga aaacctccat tggatagacc tgctactgtg aggaggttac cccactgcag 360   
gatagtctct gcccaggtct tcatgggatg aagctcttgt caacctaaat acaaacagag 420   
agaggttctc tgaaagaaga ggataattac ttgggagtag aatattgcaa tgggaatctg 480   
cttgccgtta taaactatgt gcaaattcag ggaggtaaac aagacaaaga tgctccatag 540   
aaaatatgag aagaatctca taactgtttt gagataatta ttgttagcta caaagatcaa 600   
ta                                                                602   
<210> 213
<211> 602
<212> DNA
<213> Homo sapiens
<400> 213
catagacaag ggtgagtcct tcagtactta gagaaaattc aagagtgact ttaaattccc 60    
cacttcaaat atattctctg ttttcttgtc tttcccttaa gacatctctg aatagcttcc 120   
ttcaactgcc agtgaaagat agcaggcctg atttcattgg acgcaactgt tttcagcccc 180   
aattagaggt agggtttatt ctatttaaaa taataatcaa cttgtatttt gtttcctctc 240   
ccagggtctc tggaaatttg acacagagtg ctataaaaag tatggaaaaa tgtgggggtg 300   
agtattctga aaacctccat tggatagacc tgctactgtg aggaggttac cccactgcag 360   
gatagtctct gcccaggtct tcatgggatg aagctcttgt caacctaaat acaaacagag 420   
agaggttctc tgaaagaaga ggaaaattac ttgggagtag aatattgcaa tgggaatctg 480   
cttgccgtta taaactatgt gcaaattcag ggaggtaaac aagacaaaga tgctccatag 540   
aaaatatgag aagaatctca taactgtttt gagataatta ttgttagcta caaagatcaa 600   
ta                                                                602   
<210> 214
<211> 603
<212> DNA
<213> Homo sapiens
<400> 214
agcggaaaac tcaaggaggt atgaaaataa gatgagtctt aattagaaat gtaaagaatg 60    
aatctgggga caggtagaaa gtaagatcac agtccgtttc caaggggtag tccactgagt 120   
tcgagcttcc taaaaatggt cttttatctt tatgtacaga aaagacatca caaaattcat 180   
tacaaaatgt cacttactgc tccatgctgg agaaagccat atccttctgg gacttgagtc 240   
tgcacattta actacaggta ctgatctgtt ttgtgcttag atgttcccca tcactgccca 300   
gtatggagat gtattggtga gaaacttgag gcgggaagca gagaaaggca agcctgtcac 360   
cttgaaagag taagtaggag cacagccatg gggttctgag ctgtcatgag cccttccagc 420   
tgcctgccat ggagtcgaca gtcgcactgt tgggttactc cagtgaccag acaaaagcag 480   
ggcagcgctg caactccaaa gagccaccta agagggagtg gctcccatga ggcggcaagt 540   
cagcaaggga aaagggcctt ctctcctgtg cacaggagcc aggatttact tatctgttaa 600   
ctt                                                               603   
<210> 215
<211> 60
<212> PRT
<213> Homo sapiens
<400> 215
Ser Leu Ala Glu Asp Glu Glu Trp Lys Arg Ile Arg Ser Leu Leu Ser  
1               5                  10                  15      
Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu Met Phe Pro Ile Thr Ala  
20                  25                  30          
Gln Tyr Gly Asp Val Leu Val Arg Asn Leu Arg Arg Glu Ala Glu Lys  
35                  40                  45              
Gly Lys Pro Val Thr Leu Lys Asp Ile Phe Gly Ala                  
50                  55                  60                  
<210> 216
<211> 603
<212> DNA
<213> Homo sapiens
<400> 216
agcggaaaac tcaaggaggt atgaaaataa gatgagtctt aattagaaat gtaaagaatg 60    
aatctgggga caggtagaaa gtaagatcac agtccgtttc caaggggtag tccactgagt 120   
tcgagcttcc taaaaatggt cttttatctt tatgtacaga aaagacatca caaaattcat 180   
tacaaaatgt cacttactgc tccatgctgg agaaagccat atccttctgg gacttgagtc 240   
tgcacattta actacaggta ctgatctgtt ttgtgcttag atgttcccca tcattgccca 300   
gtatggagat gtattggtga gaaacttgag gcgggaagca gagaaaggca agcctgtcac 360   
cttgaaagag taagtaggag cacagccatg gggttctgag ctgtcatgag cccttccagc 420   
tgcctgccat ggagtcgaca gtcacactgt tgggttactc cagtgaccag acaaaagcag 480   
ggcagcgctg caactccaaa gagccaccta agagggagtg gctcccatga ggcggcaagt 540   
cagcaaggga aaagggcctt ctctcctgtg cacaggagcc aggatttact tatctgttaa 600   
ctt                                                               603   
<210> 217
<211> 778
<212> DNA
<213> Homo sapiens
<400> 217
cagagcttac atatcttata tcatccacac tcaacacatg ctactgtagt tgtctgataa 60    
tgggtctctg tcttcctatg actgggctcc ttgacctcag aggtgagtct aactcagctt 120   
ggtgtctcca tcacccccag catagggcca gctccatcac tggcaccaga taaccacctt 180   
ctgagggagt agatggaaga tgattcagca gatagttctg aaagtctgtg gctctttatg 240   
tgtcttgact ggatatgtgg gtttcttgct gcatgtatag tggaaggacg gtaagaggtg 300   
ctgattttaa ttttccatat ctttctccac tcagcatctt tggggcctac agcatggatg 360   
tgattactgg cacatcattt ggagtgaaca tcgactctct caacaatcca caagacccct 420   
ttgtggagag cactaaaaag ttcctaaaat ttggtttctt agatccatta tttctctcaa 480   
taagtatgtg ggctattatt tctttctctc tttttaaaaa taactgcttt cttgacatat 540   
aattcacata tcgtataatt catccactta aaaggtacaa ttccattgtt tttaagataa 600   
tcaaaaatat gtatgaccat tactattgta aactaaaatg tttttgtcaa tctagagccc 660   
tcacacactt tagctgtcaa caccccacca caaaccccac tgccctaagc atccaataat 720   
caactttctg cctctataga tttgcctatt ctggacactt catagaaata atatcatt   778   
<210> 218
<211> 778
<212> DNA
<213> Homo sapiens
<400> 218
cagagcttac atatcttata tcatccacac tcaacacatg ctactgtagt tgtctgataa 60    
tgggtctctg tcttcctatg actgggctcc ttgacctcag aggtgagtct aactcagctt 120   
ggtgtctcca tcacccccag catagggcca gctccatcac tggcaccaga taaccacctt 180   
ctgagggagt agatggaaga tgattcagca gatagttctg aaagtctgtg gctctttatg 240   
tgtcttgact ggatatgtgg gtttcttgct gcatgtatag tggaaggacg gtaagaggtg 300   
ctgattttaa ttttccatat ctttctccac tcagcatctt tggggcctac agcatggatg 360   
tgattactgg cacatcattt ggagtgaaca tcgactctct caacaatcca caagacccct 420   
ttgtggagag cactaagaag ttcctaaaat ttggtttctt agatccgtta tttctctcaa 480   
taagtatgtg ggctattatt tctttctctc tttttaaaaa taactgcttt cttgacatat 540   
aattcacata tcgtataatt catccactta aaaggtacaa ttccattgtt tttaagataa 600   
tcaaaaatat gtatgaccat tactattgta aactaaaatg tttttgtcaa tctagagccc 660   
tcacacactt tagctgtcaa caccccacca caaaccccac tgccctaagc atccaataat 720   
caactttctg cctctataga tttgcctatt ctggacactt catagaaata atatcatt   778   
<210> 219
<211> 778
<212> DNA
<213> Homo sapiens
<400> 219
cagagcttac atatcttata tcatccacac tcaacacatg ctactgtagt tgtctgataa 60    
tgggtctctg tcttcctatg actgggctcc ttgacctcag aggtgagtct aactcagctt 120   
ggtgtctcca tcacccccag catagggcca gctccatcac tggcaccaga taaccacctt 180   
ctgagggagt agatggaaga tgattcagca gatagttctg aaagtctgtg gctctttatg 240   
tgtcttgact ggatatgtgg gtttcttgct gcatgtatag tggaaggacg gtaagaggtg 300   
ctgattttaa ttttccatat ctttctccac tcagcatctt tggggcctac agcatggatg 360   
tgattactgg cacatcattt ggagtgaaca tcgactctct caacaatcca caagacccct 420   
ttgtggagag cactaagaag ttcctaaaat ttggtttctt agatccatta tttctctcaa 480   
taagtatgtg ggctattatt tctttctctc tttttaaaaa taactgcttt cttgacatat 540   
aattcacata tcgtataatt catccactta aaaggtacaa tttcattgtt tttaagataa 600   
tcaaaaatat gtatgaccat tactattgta aactaaaatg tttttgtcaa tctagagccc 660   
tcacacactt tagctgtcaa caccccacca caaaccccac tgccctaagc atccaataat 720   
caactttctg cctctataga tttgcctatt ctggacactt catagaaata atatcatt   778   
<210> 220
<211> 778
<212> DNA
<213> Homo sapiens
<400> 220
cagagcttac atatcttata tcatccacac tcaacacatg ctactgtagt tgtctgataa 60    
tgggtctctg tcttcctatg actgggctcc ttgacctcag aggtgagtct aactcagctt 120   
ggtgtctcca tcacccccag catagggcca gctccatcac tggcaccaga taaccacctt 180   
ctgagggagt agatggaaga tgattcagca gatagttctg aaagtctgtg gctctttatg 240   
tgtcttgact ggatatgtgg gtttcttgct gcatgtatag tggaaggacg gtaagaggtg 300   
ctgattttaa ttttccatat ctttctccac tcagcatctt tggggcctac agcatggatg 360   
tgattactgg cacatcattt ggagtgaaca tcgactctct caacaatcca caagacccct 420   
ttgtggagag cactaagaag ttcctaaaat ttggtttctt agatccatta tttctctcaa 480   
taagtatgtg ggctattatt tctttctctc tttttaaaaa taactgcttt cttgacatat 540   
aattcacata tcgtataatt catccactta aaaggtacaa ttccattgtt tttaagataa 600   
tcaaaaatat gtatgaccat tactattgta aactaaaatg tttttgtcag tctagagccc 660   
tcacacactt tagctgtcaa caccccacca caaaccccac tgccctaagc atccaataat 720   
caactttctg cctctataga tttgcctatt ctggacactt catagaaata atatcatt   778   
<210> 221
<211> 670
<212> DNA
<213> Homo sapiens
<400> 221
agaaggtgcc attgatctca ctgctgtagt ggtgtttcct atgtatagac ctgcccttgc 60    
tcagtcgccg gcctgaaaga agggcaaaca tgataaaagg aatgggttcc agttgagaat 120   
catgatgttc ttattcttat tactggtaga gaaaattata attgctccag gtaaagtttg 180   
cattttcaat gatttccttt tgttcgtttt gtttttccca cagtactctt tccattcctt 240   
accccagttt ttgaagcatt aaatgtctct ctgtttccaa aagataccat aaatttttta 300   
agtaaatctg taaacagaat gaagaaaagt cgcctcaacg acaaacaaaa ggtaaaatct 360   
gatggtggtt aaatgacgat gtttaggttt tgataaattt agattttata cacatgatag 420   
agcatgtatc tgtattttta aaaataaaga cagagaactt atgtttagaa caagagaagc 480   
catttggtag aaataaagaa ggagattggg gaaggagatg agaatgagtc agagagatag 540   
catttaaaac ttgaaatcag gcacaacaat tagtatgtca tgatataaac agtattgaga 600   
taaaatttta ccacttctct tccctttaat aaattgtcaa aggataaagt ttcctgtttg 660   
aaaatatatt                                                        670   
<210> 222
<211> 670
<212> DNA
<213> Homo sapiens
<400> 222
agaaggtgcc attgatctca ctgctgtagt ggtgtttcct atgtatagac ctgcccttgc 60    
tcagtcgccg gcctgaaaga agggcaaaca tgataaaagg aatgggttcc agttgagaat 120   
catgatgttc ttattcttat tactggtaga gaaaattata attgctccag gtaaagtttg 180   
cattttcaat gatttccttt tgtttgtttt gtttttccca cagtactctt tccattcctt 240   
accccagttt ttgaagcatt aaatgtctct ctgtttccaa aagataccat aaatttttta 300   
agtaaatctg taaacagaat gaagaaaagt cgcctcaacg acaaacaaaa ggtaaaatct 360   
gatggtggtt aaatgacgat gtttaggttt tgataaattt agattttata cacatgatag 420   
agcatgtatc tgtattttta aaaataaaga cagagaactt atgtttagaa caagagaagc 480   
catttggtag aaatacagaa ggagattggg gaaggagatg agaatgagtc agagagatag 540   
catttaaaac ttgaaatcag gcacaacaat tagtatgtca tgatataaac agtattgaga 600   
taaaatttta ccacttctct tccctttaat aaattgtcaa aggataaagt ttcctgtttg 660   
aaaatatatt                                                        670   
<210> 223
<211> 826
<212> DNA
<213> Homo sapiens
<400> 223
agataaagta cttttaggat cattcaaggc acacacccat aacactgagt atgtaagaca 60    
gaaatgctct ctctggaaat tacagcagtg ctggtgctgg gatgccatga tgaggagtgt 120   
gtggcccaca atcatgtaga ccttgggaaa acctggatta aaatgatttt gcatcatcct 180   
ggccctgtat aagatacata tcagaatgaa aaccactccc agtgtgactt tgaattgctt 240   
ttccattttt tcttcttggg attagagagc ttcacttaga tttcatctaa gctgtgatgt 300   
tgtacgttga cctgatttac ctaaaatgtc tttcctctcc tttcagctct gtctgatctg 360   
gagctcgcag cccagtcaat aatcttcatt tttgctggct atgaaaccac cagcagtgtt 420   
ctttccttca ctttatatga actggccact caccctgatg tccagcagaa actgcaaaag 480   
gagattgatg cagttttgcc caataaggtg aggggatgac ccctggagat gaagggaaga 540   
ggtgaagcct tagcaaaaat gcctcctcac cactccccag gagaattttt ataaaaagca 600   
taatcactga ttccttcact gacataatgt aggaagcctc tgaggagaaa aacaaaggga 660   
gaaacataga gaacggttgc tactggcaga agcataagat ctttgtacaa tattgctggc 720   
cctggttcac ctgtttactg ttatcacaat aatgctaagt aaaaaaaaaa aaaaaaaaaa 780   
aaaaaaaaaa aggagtgtgg cgagaagatg gccaaacagg aacagc                826   
<210> 224
<211> 826
<212> DNA
<213> Homo sapiens
<400> 224
agataaagta cttttaggat cattcaaggc acacacccat aacactgagt atgtaagaca 60    
gaaatgctct ctctggaaat tacagcagtg ctggtgctgg gatgccatga tgaggagtgt 120   
gtggcccaca atcatgtaga ccttgggaaa acctggatta aaatgatttt gcgtcatcct 180   
ggccctgtat aagatacata tcagaatgaa aaccactccc agtgtgactt tgaattgctt 240   
ttccattttt tcttcttggg attagagagc ttcacttaga tttcatctaa gctgtgatgt 300   
tgtacgttga cttgatttac ctaaaatgtc tttcctctcc tttcagctct gtctgatctg 360   
gagctcgcag cccagtcaat aatcttcatt tttgctggct atgaaaccac cagcagtgtt 420   
ctttccttca ctttatatga actggccact caccctgatg tccagcagaa actgcaaaag 480   
gagattgatg cagttttgcc caataaggtg aggggatgac ccctggagat gaagggaaga 540   
ggtgaagcct tagcaaaaat gcctcctcac cactccccag gagaattttt ataaaaagca 600   
taatcactga ttccttcact gacataatgt aggaagcctc tgaggagaaa aacaaaggga 660   
gaaacataga gaacggttgc tactggcaga agcataagat ctttgtacaa tattgctggc 720   
cctggttcac ctgtttactg ttatcacaat aatgctaagt aaaaaaaaaa aaaaaaaaaa 780   
aaaaaaaaaa aggagtgtgg cgagaagatg gccaaacagg aacagc                826   
<210> 225
<211> 616
<212> DNA
<213> Homo sapiens
<400> 225
caggcctggc acagagtcag tgctccataa atattttgtt aaacgatgga tggtgagtgc 60    
ttttactatc cagtatttac ccagcttata gattaagtat gaagagttca agatacatgg 120   
tgttaagagt cgtttttata tgcttgcaaa gcatttttgt catatttttt ctactttgct 180   
tccatctttt cttctttcac ttcatttatt aattctccat atgcttgttt aactattgca 240   
gatccccttg aaattagaca cgcaaggact tcttcaacca gaaaaaccca ttgttctaaa 300   
ggtggattca agagatggaa ccctaagtgg agaatgagtt attctaagga tttctacttt 360   
ggtcttcaag aaagctgtgc cccagaacac cagagatttc aacttagtca ataaaacctt 420   
gaaataaaga tgggcttaat ctaatgtact gcatgagtag ttggtgattt tgtacattca 480   
ttgagctctc ccagagtctg tgtagagtgt tgtgcattat gtagtataaa ggaggtgacc 540   
aggtaagtga cagataggta gactcagctt ctctgcttct cataggacta cctctaccca 600   
cctctagtta gcatta                                                 616   
<210> 226
<211> 624
<212> DNA
<213> Homo sapiens
<400> 226
gattaagctt ttcatgattc ctcatagaac atgaactcaa aagaggtcag caaaggggtg 60    
tgtgcgattc tttgctattg gctgcagcta tagccctgcc tccttctcca gcacataaat 120   
ctttcagcag cttggctgaa gactgctgtg cagggcaggg aagctccagg caaacagccc 180   
agcaaacagc agcactcagc taaaaggaag actcacagaa cacagttgaa gaaggaaagt 240   
ggcgatggac ctcatcccaa atttggcggt ggaaacctgg cttctcctgg ctgtcagcct 300   
ggtgctcctc tatctgtgag taactgtcca aactcctctc tttgtttcct tggacttggg 360   
gtgctaatcg ggcccctttc cccttatctg ttttgaagat caaaagagat gttcaaggag 420   
aagtagctga agtgttggac gctacaaacg catagaagtt attattatct tatgcagatc 480   
tatgaatgaa taaataagca tttctcccat ccaccttcta attttggtga ctaggagggt 540   
ttagggacag catttggtag tgggaatgat ttgattagct tagatctgac gaagactaat 600   
caatgaaaac atggcagcgg caga                                        624   
<210> 227
<211> 624
<212> DNA
<213> Homo sapiens
<400> 227
gattaagctt ttcatgattc ctcatagaac atgaactcaa aagaggtcag caaaggggtg 60    
tgtgcgattc tttgctattg gctgcagcta tagccctgcc tccttctcca gcacataaat 120   
ctttcagcag cttggctgaa gactgctgtg cagggcaggg aagctccagg caaacagccc 180   
agcaaacagc agcactcagc taaaaggaag actcacagaa cacagttgaa gaaggaaagt 240   
ggcgatggac ctcatcccaa atttggcggt ggaaacctgg cttctcctgg ctgtcagcct 300   
ggtgctcctc tatctgtgag taactgtcca aactcctctc tttgtttcct tggacttggg 360   
gtgctaatcg ggcccctttt cccttatctg ttttgaagat caaaagagat gttcaaggag 420   
aagtagctga agtgttggac gctacaaacg catagaagtt attattatct tatacagatc 480   
tatgaatgaa taaataagca tttctcccat ccaccttcta attttggtga ctaggagggt 540   
ttagggacag catttggtag tgggaatgat ttgattagct tagatctgac gaagactaat 600   
caatgaaaac atggcagcgg caga                                        624   
<210> 228
<211> 626
<212> DNA
<213> Homo sapiens
<400> 228
gaacagttcc ctaccacgtg gagcatttgc aattaaaagg agactgagat atagaggcag 60    
gagaccacac cagatggctg ggtctcccca ctcccacccc cgccccacat acactcagaa 120   
gaggctaggc atctaggatc tccattgagc atcttgaata tggcttgcca taatatcata 180   
tacagtcaat aaatatttgt taaataagga tgcctcttca atatattttg tgcaaccatg 240   
aagatcacca caactaatgt gagaaaaaat gtttctgttg aactctagtc tttaggccca 300   
gtgggattta tgaaaagtgc catctcttta gctgaggatg aagaatggaa gagaatacag 360   
tcattgctgt ctccaacctt caccagcgga aaactcaagg aggtatgaaa ataagatgag 420   
tcttaattag aaatgtaaag aatgaatctg gggacaggta gaaagtaaga tcacagtccg 480   
tttccaaggg gtagtccact gagttcgagc ttcctaaaaa tggtctttta tctttatgta 540   
cagaaaagac atcacaaaat tcattacaaa atgtcactta ctgctccatg ctggagaaag 600   
ccatatcctt ctgggacttg agtctg                                      626   
<210> 229
<211> 60
<212> PRT
<213> Homo sapiens
<400> 229
Ser Val Phe Thr Asn Arg Arg Ser Leu Gly Pro Val Gly Phe Met Lys  
1               5                  10                  15      
Ser Ala Ile Ser Leu Ala Glu Asp Glu Glu Trp Lys Arg Ile Gln Ser  
20                  25                  30          
Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu Met Phe Pro  
35                  40                  45              
Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn                  
50                  55                  60                  
<210> 230
<211> 626
<212> DNA
<213> Homo sapiens
<400> 230
gaacagttcc ctaccacgtg gagcatttgc aattaaaagg agactgagat atagaggcag 60    
gagaccacac cagatggctg ggtctcccca ctcccacccc cgccccacat acactcagaa 120   
gaggctaggc atctaggatc tccattgagc atcttgaata tggcttgcca taatatcata 180   
tacagtcaat aaatatttgt taaataagga tgcctcttca atatattttg tgcaaccatg 240   
aagatcacca caactaatgt gagaaaaaat gtttctgttg aactctagtc tttaggccca 300   
gtgggattta tgaaaagtgc catctcttta gctgaggatg aagaatggaa gagaatacgg 360   
tcattgctgt ctccaacctt caccagcgga aaactcaagg aggcatgaaa ataagatgag 420   
tcttaattag aaatgtaaag aatgaatctg gggacaggta gaaagtaaga tcacagtccg 480   
tttccaaggg gtagtccact gagttcgagc ttcctaaaaa tggtctttta tctttatgta 540   
cagaaaagac atcacaaaat tcattacaaa atgtcactta ctgctccatg ctggagaaag 600   
ccatatcctt ctgggacttg agtctg                                      626   
<210> 231
<211> 626
<212> DNA
<213> Homo sapiens
<400> 231
gaacagttcc ctaccacgtg gagcatttgc aattaaaagg agactgagat atagaggcag 60    
gagaccacac cagatggctg ggtctcccca ctcccacccc cgccccacat acactcagaa 120   
gaggctaggc atctaggatc tccattgagc atcttgaata tggcttgcca taatatcata 180   
tacagtcaat aaatatttgt taaataagga tgcctcttca atatattttg tgcaaccatg 240   
aagatcacca caactaatgt gagaaaaaat gtttctgttg aactctagtc tttaggccca 300   
gtgggattta tgaaaagtgc catctcttta gctgaggatg aagaatggaa gagaatacgg 360   
tcattgctgt ctccaacctt caccagcgga aaactcaagg aggtatgaaa ataagatgag 420   
tcttaattag aaatgtaaag aatgaatctg gggacaggta gaaagtaaga tcacagtcca 480   
tttccaaggg gtagtccact gagttcgagc ttcctaaaaa tggtctttta tctttatgta 540   
cagaaaagac atcacaaaat tcattacaaa atgtcactta ctgctccatg ctggagaaag 600   
ccatatcctt ctgggacttg agtctg                                      626   
<210> 232
<211> 623
<212> DNA
<213> Homo sapiens
<400> 232
attggacatg atagctagat ttgtttcagg aaaacatcct gctttccaag gatttagatg 60    
aatgtttttg ttcactggtg actcaggtaa cacgtcttca agaagccata gggaggttga 120   
gggagggaag tcaagaaggg aggttgagga ctgcactttt gatttacttc tgacttcacg 180   
agtcactttc tgcgaaagaa atctctcctt ttgcttctag caccgactag atttccttca 240   
gctgatgatt gactcccaga attcgaaaga aactgagtcc cacaaaggta accaaggagt 300   
gcttctgagg gctactggcg gggacactaa gagggagggc cttgttctga aaatgtgcag 360   
gaagtattcc aggaagatga gaatttttgc cacatagcag aacaacacac atttagatgt 420   
tataaatggt agctggaggc actttccaga agcccacagg tatagccatg ttccaggctg 480   
aaagggcaac cctaagcaaa cctagaatgc ttggaggaca gtcagtggtt tgtggatcac 540   
ctacatgaga tcaaatgcca gttctcagcc tcctccagat ccaccaagtg agaacctcta 600   
cttggaaatt tatatcaaac ata                                         623   
<210> 233
<211> 616
<212> DNA
<213> Homo sapiens
<400> 233
caggcctggc acagagtcag tgctccataa atattttgtt aaacgatgga tggtgagtgc 60    
ttttactatc cagtatttac ccagcttata gattaagtat gaagagttca agatacatgg 120   
tgttaagagt cgtttttata tgcttgcaaa gcatttttgt catatttttt ctactttgct 180   
tccatctttt cttctttcac ttcatttatt aattctccat atgcttgttt aactattgta 240   
gatccccttg aaattagaca cgcaaggact tcttcaacca gaaaaaccca ctgttctaaa 300   
ggtggattca agagatggaa ccctaagtgg agaatgagtt attctaagga tttctacttt 360   
ggtcttcaag aaagctgtgc cccagaacac cagagatttc aacttagtca ataaaacctt 420   
gaaataaaga tgggcttaat ctaatgtact gcatgagtag ttggtgattt tgtacattca 480   
ttgagctctc ccagagtctg tgtagagtgt tgtgcattat gtagtataaa ggaggtgacc 540   
aggtaagtga cagataggta gactcagctt ctctgcttct cataggacta cctctaccca 600   
cctctagtta gcatta                                                 616   
<210> 234
<211> 59
<212> PRT
<213> Homo sapiens
<400> 234
Met Arg Phe Ala Leu Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu  
1               5                  10                  15      
Gln Asn Phe Ser Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys  
20                  25                  30          
Leu Asp Thr Gln Gly Leu Leu Gln Pro Glu Lys Pro Thr Val Leu Lys  
35                  40                  45              
Val Asp Ser Arg Asp Gly Thr Leu Ser Gly Glu                      
50                  55                                      
<210> 235
<211> 830
<212> DNA
<213> Homo sapiens
<400> 235
tggtcaccca ccatgtgtac agtaccctgc tagggtccag ggtcatgaaa gtaaataata 60    
ccagactgtg cccttgagga actcacctct gctaagggaa acaggcacag aaacccacaa 120   
gggtggtaga gaggaaatag gacaatagga ctgtgtgagg gggataggag gcacccagag 180   
gaggaaatgg ttacatctgt gtgaggaggt tggtaaggaa agactttaat agaaggggtc 240   
tgtctggctg ggcttgcaag gatgtgtagg agtcatctag ggggcacaag tacactccag 300   
gcagagggaa ttgcatgggt aaagatctgc agttgtggct tgtggggatg gatttcaagt 360   
attctggaat gaagacagcc atggaaacaa gggcaggtga gaggatattt aagaggcttc 420   
atgccaatgg ctccacttca gtttctgata agaactcagg ttccgtggac tccctgataa 480   
aactgattaa gttgtttatg attccccata gaatatgaac tcaaaggagg taagcaaagg 540   
ggtgtgtgcg attctttgct accggctgca gctgcagccc cacctccttc tccagcacat 600   
aaacatttca gcagcttgac ctaagactgc tgtgcagggc agggatgctc caggcagaca 660   
gcccagcaaa caacagcaca cagctgaaag taagactcag aggagacagt tgaagaaggc 720   
aagtggcgat ggacctcatc ccaaatttgg cggtggaaac ctggcttctc ctggctgtca 780   
gcctggtgct cctctatctg tcagtaactg tccagattcc tctcctctgt            830   
<210> 236
<211> 775
<212> DNA
<213> Homo sapiens
<400> 236
ggagtgacct gattttccag gtgctgtctg tcaccccttt ctttgactag gaaagggaac 60    
tccttgaccc cttgcgcttc tcaagtgagg caatgcctcg ccctgcttcg gcttgtgcac 120   
agcacgctgc acccactgtc ctgcacccac tgtctggcac tccctagtga gatgaacccg 180   
gtacctcaga tgaaaatgca gaaattaccc gtcttctgtg tcactcacac tgggagctgt 240   
agaccggagc tgttcctatt cggccatctt ggctccaccc cccgagtttt ggcttttaat 300   
tgaaagtgta ttgatgtggg aaggagataa tgccatgcat ttatgagcac atattagagg 360   
gtctgagaca atgcatgtga taaaaggtca cctaaggaag aaaaaaagaa caagggaaga 420   
cactggaaag aacgtgatgc tgggagtccc tgggccacca aagtctggag aaaagtggta 480   
accacaaggc tcccagccta gtttcactga agacctcgac actaggtgac ttatgggatc 540   
cttggtagga caagccttga aaagttttac aatagcaaat gtggacgttg tcagaaccaa 600   
atgatgtcac gtgtgtattt gtgtgtgtgt gtcagtgtgt gtgtttaaaa atcatgacaa 660   
ataaagcagg ctgtgaagag gggattccca tgctcgtgtg cctgataaca caactatcac 720   
aaacgctttg cgaaaccaca agtttgcaca aaggcaatcc caaccttaca caaaa      775   
<210> 237
<211> 25
<212> DNA
<213> Homo sapiens
<400> 237
ttgttgggaa atgttttgtc ctatc                                       25    
<210> 238
<211> 24
<212> DNA
<213> Homo sapiens
<400> 238
acagggagtt gaccttcata cgtt                                        24    
<210> 239
<211> 33
<212> DNA
<213> Homo sapiens
<400> 239
tcagggtctc tggaaatttg acacagagtg cta                              33    
【図面の簡単な説明】