【手続補正書】
【提出日】平成17年8月24日(2005.8.24)
【手続補正１】
【補正対象書類名】明細書
【補正対象項目名】００８１
【補正方法】変更
【補正の内容】
【００８１】
【配列表】
<110> Tanabe Seiyaku Co., Ltd.
<120> Bone Forming Related Gene
<130> A00-4635
<140> JP H10-318226 
<141> 1998-11-10
<160> 10
<210> 1
<211> 2457
<212> DNA
<213> mouse
<220>
<221> CDS
<222> (205)..(1824)
<400> 1
cccaccatga ctgtgctcga gccatagcgc ctctcccggc cttccaagag gacccacact           60 
tcttcctgta ggtggcaaca gtgacacctg tttgaccagt gaggctgagc cagggactgc          120 
aagagggagg aggcagacaa ctcggagagg agctgggagg cagagctgcg ggcttgcttg          180
ctcactgtgt aaaaggcctt aacc atg gca gat tcc ccc ggc tgc tgc tcc atc tgg     237
Met Ala Asp Ser Pro Gly Cys Cys Ser Ile Trp 
1               5                  10
gcc cgc tgc ctc cac tgc ctg tac agc tgc cac tgg agg aaa tat cct            285
Ala Arg Cys Leu His Cys Leu Tyr Ser Cys His Trp Arg Lys Tyr Pro 
15                  20                  25   
aaa cag aag atg caa acc agc aag tgc gac tgt atc tgg ttt ggc ctg            333
Lys Gln Lys Met Gln Thr Ser Lys Cys Asp Cys Ile Trp Phe Gly Leu  
30                  35                  40                            
ctc ttc ctc acc ttc ctc ctg tcc ctg gga tgg ctg tac atc ggg ctc            381
Leu Phe Leu Thr Phe Leu Leu Ser Leu Gly Trp Leu Tyr Ile Gly Leu
45                  50                  55                 
atc ctt ctc aat gat ctg cac aac ttc aat gaa ttc ctg ttc cgc cat            429
Ile Leu Leu Asn Asp Leu His Asn Phe Asn Glu Phe Leu Phe Arg His 
60                   65                  70                 75  
tgg gga cac tgg atg gac tgg tcc ctg ata gtc ctg ctg gtc gtc tct            477
Trp Gly His Trp Met Asp Trp Ser Leu Ile Val Leu Leu Val Val Ser
80                  85                  90
ctc ctg gtc aca tat gca tcc ttg cta ttg ctc ctg ggc ctg ctc ctg            525
Leu Leu Val Thr Tyr Ala Ser Leu Leu Leu Leu Leu Gly Leu Leu Leu 
95                  100                 105      
caa ctc tgt gga cag cct ctg cat ctt cac agt ctc cac aag gtg ctg            573
Gln Leu Cys Gly Gln Pro Leu His Leu His Ser Leu His Lys Val Leu 
110                 115                 120   
ctg ctc ctc att gta ctt cta gtg gcc gcg gga ctg gtg ggc ctg gat            621
Leu Leu Leu Ile Val Leu Leu Val Ala Ala Gly Leu Val Gly Leu Asp
125                 130                 135                 
atc caa tgg cgg cag gag tgg cat agt tta cga ctg tca ctg cag gcc            669
Ile Gln Trp Arg Gln Glu Trp His Ser Leu Arg Leu Ser Leu Gln Ala
140                 145                 150                 155 
aca gcc cca ttc ctt cac att gga gca gtt gct gga atc acc ttg ttg            717
Thr Ala Pro Phe Leu His Ile Gly Ala Val Ala Gly Ile Thr Leu Leu
160                 165                 170 
gcc tgg cct gtg gct gat acc ttc tac cgc atc cac cca aga ggc ccc            765
Ala Trp Pro Val Ala Asp Thr Phe Tyr Arg Ile His Pro Arg Gly Pro 
175                 180                 185 
aag gtt ctg cta ctg ttg cta ttt ttt gga gtc act ctg gtc atc tac            813
Lys Val Leu Leu Leu Leu Leu Phe Phe Gly Val Thr Leu Val Ile Tyr 
190                 195                 200
ctg atg ccg ctg ctg ttc atc tct tcc ccc tgc atc atg aaa ctc aga            861
Leu Met Pro Leu Leu Phe Ile Ser Ser Pro Cys Ile Met Lys Leu Arg
205                 210                 215                     
gat tta ccc ccc aag cct ggg ctg gtg gga cac cga ggg gcc ccc atg            909
Asp Leu Pro Pro Lys Pro Gly Leu Val Gly His Arg Gly Ala Pro Met 
220                 225                 230                 235
ctg gcc cct gag aat acc ctg atg tcc ctg agg aag aca gct gaa tgt            957
Leu Ala Pro Glu Asn Thr Leu Met Ser Leu Arg Lys Thr Ala Glu Cys 
240                 245                 250
gga gcg gct gtg ttt gag aca gat gtg atg gtc agc tct gac gga gtc            1005
Gly Ala Ala Val Phe Glu Thr Asp Val Met Val Ser Ser Asp Gly Val
255                 260                 265
ccc ttt ctc atg cat gat gag cga ctg agc agg act acc aat gta gcc            1053
Pro Phe Leu Met His Asp Glu Arg Leu Ser Arg Thr Thr Asn Val Ala
270                 275                 280
tct gtg ttt cca gag cga atc tca gcc cac agc agt gac ttc tcc tgg            1101
Ser Val Phe Pro Glu Arg Ile Ser Ala His Ser Ser Asp Phe Ser Trp 
285                 290                 295                  
gct gaa ctg cag aga ctc aat gct gga acc tgg ttc cta gag agg caa            1149
Ala Glu Leu Gln Arg Leu Asn Ala Gly Thr Trp Phe Leu Glu Arg Gln 
300                 305                 310                 315   
cct ttc tgg ggg gcc aaa aag ctg tca ggc tct gat cgg aag gag gct            1197
Pro Phe Trp Gly Ala Lys Lys Leu Ser Gly Ser Asp Arg Lys Glu Ala 
320                 325                 330    
gag aat cag acc ata cca gca tta gaa gaa cta ctg aag gaa gca gca            1245
Glu Asn Gln Thr Ile Pro Ala Leu Glu Glu Leu Leu Lys Glu Ala Ala 
335                 340                 345
gct ctc aac ctt tcc atc atg ttt gac ttg cgc cga ccc cca aga aac            1293
Ala Leu Asn Leu Ser Ile Met Phe Asp Leu Arg Arg Pro Pro Arg Asn
350                 355                 360
cac aca tac tat gat act ttt gtg aat cag aca ctg gag gct gtg ttg            1341
His Thr Tyr Tyr Asp Thr Phe Val Asn Gln Thr Leu Glu Ala Val Leu 
365                 370                 375                 
agt gca aac gtg tcc caa gct atg gtt ctt tgg ctc cca gat gaa gac            1389
Ser Ala Asn Val Ser Gln Ala Met Val Leu Trp Leu Pro Asp Glu Asp 
380                 385                 390                 395    
cgt gct aac gtg cag caa cgc gcc ccc aga atg cgc cag ata tat gga            1437
Arg Ala Asn Val Gln Gln Arg Ala Pro Arg Met Arg Gln Ile Tyr Gly 
400                 405                 410
cat cag gga ggc aat tgg act gag agg ccc cag ttt ctc aac ctc ccc            1485
His Gln Gly Gly Asn Trp Thr Glu Arg Pro Gln Phe Leu Asn Leu Pro
415                 420                 425
tat caa gac ctg cca gca ttg gat atc aag gcc ctg cac cag gat aat            1533
Tyr Gln Asp Leu Pro Ala Leu Asp Ile Lys Ala Leu His Gln Asp Asn 
430                 435                 440
atc tca gtg aac ctg ttt gta gtg aac aag ccc tgg ctc ttc tcc ctg            1581
Ile Ser Val Asn Leu Phe Val Val Asn Lys Pro Trp Leu Phe Ser Leu 
445                 450                 455                
ctc tgg tgt gca ggg gtg gat tct gtc acc acc aat gcc tgc cag ctg            1629
Leu Trp Cys Ala Gly Val Asp Ser Val Thr Thr Asn Ala Cys Gln Leu 
460                 465                 470                 475
ctg caa cag atg cag aac ccc ctc tgg ctt ctt ccc cct caa aaa tac            1677
Leu Gln Gln Met Gln Asn Pro Leu Trp Leu Leu Pro Pro Gln Lys Tyr
480                 485                 490
tta atg att tgg gtg atc acc gac tgt gcc tcc att ctg ctg ctt ttg            1725
Leu Met Ile Trp Val Ile Thr Asp Cys Ala Ser Ile Leu Leu Leu Leu 
495                 500                 505    
agt atc ttc ctc ctc cga ggg gga tgt gct aag aga aac aga aca ggc            1773
Ser Ile Phe Leu Leu Arg Gly Gly Cys Ala Lys Arg Asn Arg Thr Gly
510                 515                 520 
tta gaa aca gca gtg cta ctg acc aag atc aac aat ttc gcc tct gag            1821
Leu Glu Thr Ala Val Leu Leu Thr Lys Ile Asn Asn Phe Ala Ser Glu
525                 530                 535        
tga atgccgggcc caggccgcca ccagctgctg tctaaggcct gtgtgcactg                 1874 
ttcaaaggga aggacaggag ctgaagtgga atgtcctaga atcaaatgtt tggaggaggg          1934 
agcattgcta acagaagatt ttgaactcag agggccctct gtccagatgg tgggcatgtc          1994 
tcaagctgcc atggaatttg ctgcctttgg tgtttgacat gaattagtcg gaaagacagt          2054 
gactgacaag aagttactcc caaaatgaaa ttaaagcaag gaagtgagag agattgccaa          2114 
gataatgcat taggcttgtg tgcacatgta cttggataga agaagcaggg tgtgtcaggg          2174 
tgggatagct cagaatgatg actgaaggaa atttggccac aatggccttt ccggaagaac          2234 
tcttaagatg ctgaagacag tccacactcc atgccttctc ttctcaccct cacacttcat          2294 
cttcttttct gcctacaggc tgggagtgaa aaagctcatt tagcaatata atattgtgtc          2354 
tatggtaggt ttttgttgtg agcaatgaat ggttcctgta tcttgcctgt taatctgtta          2414 
ttcaatgaat ttttaatttg tcatttgaaa aaaaaaaaaa aaa                            2457 
<210> 2
<211> 2199
<212> DNA
<213> human
<220>
<221> CDS
<222> (252)..(1871)
<400> 2
gcagatttgc tctccctccc gcttcctccc tcccatcttc ccacccgggc tgtgcccagg            60 
ccacagagca gctgcaggcc ttgggagagg acccacacag cctcctgtag gtggcaacag           120 
tgccacctgt ttgactcata gggctgaacc gaggactgaa aaagggagga ggcagaccac           180 
tcggagagga gctgggaagc agtgcagaga ggagagcgga gcggagctgc cgctgagcaa           240 
aggccttcac c atg gcc gag tcc ccc ggc tgc tgc tcc gtc tgg gcc cgc tgc ctc    296
Met Ala Glu Ser Pro Gly Cys Cys Ser Val Trp Ala Arg Cys Leu  
1              5                   10                  15 
cac tgc ctg tat agc tgc cac tgg agg aaa tgc ccc aga gag agg atg             344
His Cys Leu Tyr Ser Cys His Trp Arg Lys Cys Pro Arg Glu Arg Met 
20                   25                 30
caa acc agc aag tgc gac tgt atc tgg ttt ggc ctg ctc ttc ctc acc             392 
Gln Thr Ser Lys Cys Asp Cys Ile Trp Phe Gly Leu Leu Phe Leu Thr 
35                  40                  45  
ttc ctc ctt tcc ctg agc tgg ctg tac atc ggg ctc gtc ctt ctc aat             440 
Phe Leu Leu Ser Leu Ser Trp Leu Tyr Ile Gly Leu Val Leu Leu Asn  
50                  55                 60
gac ctg cac aac ttc aat gaa ttc ctc ttc cgc cgc tgg gga cac tgg             488 
Asp Leu His Asn Phe Asn Glu Phe Leu Phe Arg Arg Trp Gly His Trp 
65                   70                  75                  
atg gac tgg tcc ctg gca ttc ctg ctg gtc atc tct cta ctg gtc aca             536 
Met Asp Trp Ser Leu Ala Phe Leu Leu Val Ile Ser Leu Leu Val Thr 
80                   85                  90                  95 
tat gca tcc ttg cta ttg gtc ctg gcc ctg ctc ctg cgg ctt tgt aga             584 
Tyr Ala Ser Leu Leu Leu Val Leu Ala Leu Leu Leu Arg Leu Cys Arg 
100                 105                 110
cag ccc ctg cat ctg cac agc ctc cac aag gtg ctg ctg ctc ctc att             632
Gln Pro Leu His Leu His Ser Leu His Lys Val Leu Leu Leu Leu Ile 
115                 120                 125
atg ctg ctt gtg gcg gct ggc ctt gtg gga ctg gac atc caa tgg cag             680
Met Leu Leu Val Ala Ala Gly Leu Val Gly Leu Asp Ile Gln Trp Gln 
130                 135                 140 
cag gag tgg cat agc ttg cgt gtg tca ctg cag gcc aca gcc cca ttc             728 
Gln Glu Trp His Ser Leu Arg Val Ser Leu Gln Ala Thr Ala Pro Phe 
145                 150                 155                 
ctt cat att gga gca gcc gct gga att gcc ctc ctg gcc tgg cct gtg             776 
Leu His Ile Gly Ala Ala Ala Gly Ile Ala Leu Leu Ala Trp Pro Val 
160                 165                 170                 175
gct gat acc ttc tac cgt atc cac cga aga ggt ccc aag att ctg cta             824
Ala Asp Thr Phe Tyr Arg Ile His Arg Arg Gly Pro Lys Ile Leu Leu  
180                 185                 190    
ctg ctc cta ttt ttt gga gtt gtc ctg gtc atc tac ttg gcc ccc cta             872
Leu Leu Leu Phe Phe Gly Val Val Leu Val Ile Tyr Leu Ala Pro Leu  
195                 200                 205
tgc atc tcc tca ccc tgc atc atg gaa ccc aga gac tta cca ccc aag             920
Cys Ile Ser Ser Pro Cys Ile Met Glu Pro Arg Asp Leu Pro Pro Lys  
210                 215                 220 
cct ggg ctg gtg gga cac cga ggg gcc ccc atg ctg gct ccc gag aac             968 
Pro Gly Leu Val Gly His Arg Gly Ala Pro Met Leu Ala Pro Glu Asn 
225                 230                 235                 
acc ctg atg tcc ttg cgg aag aca gct gaa tgc gga gct act gtg ttt            1016 
Thr Leu Met Ser Leu Arg Lys Thr Ala Glu Cys Gly Ala Thr Val Phe 
240                 245                 250                 255 
gag act gat gtg atg gtc agc tcc gat ggg gtc ccc ttc ctc atg cat            1064 
Glu Thr Asp Val Met Val Ser Ser Asp Gly Val Pro Phe Leu Met His 
260                 265                 270
gat gag cac ctc agc agg acc acg aat gta gcc tct gta ttc cca accv           1112 
Asp Glu His Leu Ser Arg Thr Thr Asn Val Ala Ser Val Phe Pro Thr 
275                 280                 285
cga atc aca gcc cac agc agt gac ttc tcc tgg act gaa ctg aag aga            1160 
Arg Ile Thr Ala His Ser Ser Asp Phe Ser Trp Thr Glu Leu Lys Arg 
290                 295                 300   
ctc aat gct gga tcc tgg ttc cta gag agg cga ccc ttc tgg ggg gcc            1208 
Leu Asn Ala Gly Ser Trp Phe Leu Glu Arg Arg Pro Phe Trp Gly Ala  
305                 310                 315                 
aaa ccg ctg gca ggc cct gat cag aaa gag gct gag agt cag acg gta            1256 
Lys Pro Leu Ala Gly Pro Asp Gln Lys Glu Ala Glu Ser Gln Thr Val 
320                 325                 330                 335 
cca gca tta gaa gag cta ttg gag gaa gct gca gcc ctc aac ctt tcc            1304 
Pro Ala Leu Glu Glu Leu Leu Glu Glu Ala Ala Ala Leu Asn Leu Ser  
340                 345                 350
atc atg ttc gac ttg cgc cga ccc cca cag aac cac aca tac tat gac            1352 
Ile Met Phe Asp Leu Arg Arg Pro Pro Gln Asn His Thr Tyr Tyr Asp 
355                 360                 365
act ttt gtg atc cag aca ttg gag act gtg ctg aat gca agg gtg ccc            1400 
Thr Phe Val Ile Gln Thr Leu Glu Thr Val Leu Asn Ala Arg Val Pro  
370                 375                 380 
caa gcc atg gtc ttt tgg cta cca gat gaa gat cgg gct aat gtc caa            1448
Gln Ala Met Val Phe Trp Leu Pro Asp Glu Asp Arg Ala Asn Val Gln  
385                 390                 395                
cga cgg gca cct gga atg cgc cag ata tat gga cgt cag gga ggc aac            1496 
Arg Arg Ala Pro Gly Met Arg Gln Ile Tyr Gly Arg Gln Gly Gly Asn  
400                 405                 410                 415  
aga acg gag agg ccc cag ttt ctt aac ctc ccc tat caa gat ctg cca            1544 
Arg Thr Glu Arg Pro Gln Phe Leu Asn Leu Pro Tyr Gln Asp Leu Pro 
420                 425                 430 
cta ttg gat atc aag gca ttg cat aag gat aat gtc tcg gtg aac cta            1592
Leu Leu Asp Ile Lys Ala Leu His Lys Asp Asn Val Ser Val Asn Leu 
435                 440                 445 
ttt gta gtg aac aag ccc tgg ctc ttc tct ctg ctt tgg tgt gca ggg            1640 
Phe Val Val Asn Lys Pro Trp Leu Phe Ser Leu Leu Trp Cys Ala Gly 
450                 455                 460 
gtg gat tcg gtc acc acc aac gac tgc cag ctg ctg cag cag atg cgt            1688 
Val Asp Ser Val Thr Thr Asn Asp Cys Gln Leu Leu Gln Gln Met Arg 
465                 470                 475                 
tac cct atc tgg ctt att acc cct caa acc tac cta atc ata tgg gtc            1736
Tyr Pro Ile Trp Leu Ile Thr Pro Gln Thr Tyr Leu Ile Ile Trp Val 
480                 485                 490                 495 
att acc aat tgt gtt tcc acc atg ctg ctt ttg tgg acc ttc ctc ctc            1784
Ile Thr Asn Cys Val Ser Thr Met Leu Leu Leu Trp Thr Phe Leu Leu 
500                 505                 510
caa agg aga ttt gtt aag aag aga ggg aaa act ggc tta gaa aca gca            1832
Gln Arg Arg Phe Val Lys Lys Arg Gly Lys Thr Gly Leu Glu Thr Ala 
515                 520                 525 
gtg ctg ctg aca agg atc aac aat ttc atg atg gag tga atgccctgcc             1881 
Val Leu Leu Thr Arg Ile Asn Asn Phe Met Met Glu
530                 535              
ctgcttcccc acccaagcca gtctacattg cccaaacagc aagggttgga gagtggctta          1941
agtggaatgc ttcaggggtg gtgggttgca agtgggggga gctttgccaa caggaggttt          2001 
tgaaccatga gggccctctg cccaggtgat gggcattccc taagctgcta tggaatctgc          2061 
tccctttggg gttttgacct gagatgtttg ggaagagagt gagtaatgag aagtttctcc          2121 
tcaaatgaaa ctagaacaga ggaagtaaaa gggagattgc tcggaaaaaa aaaaaaaaaa          2181 
aaaaaaaaaa aaaaaaaa                                                        2199 
<210> 3
<211> 2529
<212> DNA
<213> mouse
<220>
<221> exon
<222> 2314..2508
<223> exon 1
<400> 3
tgatgcccac ttctggctta caggcatata tgtagttaga acactgtata catatgtctt            60 
agtcagggtt tctattcctg cacaaacatc atgaccaaga agcaagttgg ggcagaaagg           120 
gtttattcgg cctatacttc catactgcag ttcatcacca aggaagtcag gactggaact           180 
caagcaggtc aggaagcagg agctgatgca gaggccatgg agggatgtta cttactggct           240 
tgcttcccct ggcttgccca gcctgctcag ttatagaacc aagactacca gcccagagat           300 
ggtcccaccc acaaggggtc tttccccctt aatcactaat tgagaaagtg ccttacagat           360 
ggatctcatg gaggcatttt ctcaactgaa gctcctttct ctgtgataac tccagctgtg           420 
tcaagttgac acaaaactag ccagtacaac atagtaaaca aatcttttta aaaaaatgtt           480 
caaggtcctt agcctgtact ttgcatataa gaaaatcaag tgtctgcttt accatacaat           540 
agcaaatact tgagagatgg agttgtctgg agaatgtgtt taatttagct catggtgttg           600 
gaggccctgg gccatgctta gaaacccata ttagttcatg acagaagtac gatggagcag           660 
gatggaagaa aatagtggaa ggatctgggt cccatcacca gccttcgaga gcatactctc           720 
cagtatacaa aagacagaca ctccacgaga acctacctcg ctataaagtt tcccccaacc           780 
tcccaaattg taccacaggc cagggaacaa gctgtgaaca cacaagccct tggggaacat           840 
taaatatcta acagagatag taccgtggta caaagaggtg gttatataga gttacaatgt           900 
cagtgaatat tagagctggg aacagaagcc agttacattt accatatagt tctttctagt           960 
gccctgcaat cctactaatg cttttccgtt tacagaacaa aactactgcc cccttgcttt          1020 
ctcccttaaa aaggaagtgg gggtgggggg ggacaaggat tattccttac cttatgccag          1080 
atttcttgtc tccagttaga agccagaagg ggggccagcc atgcagtacc tcatacaggc          1140 
tatatttgaa accttttggg agttttcaag ccttgaggct catccatgca tatcgaatgc          1200 
tgtccccacc ccaccacccc ctaaaaggct ctcaaaccat ccccacgtac aagaaaacaa          1260 
gactctagaa tccaccacaa cccaagcaaa ggaaattgaa aaacaacctg ccaagaatga          1320 
ctcccagtgg aggactaggt gacccgctgg ccctccctgg cttcctgcca gcaagcagcc          1380 
ttgcttctct ttgcatttta attctgagag agttagagaa tctctgtcat tgccaaatag          1440 
agcctctgga tacaatggga aagctgagag ggagggaacc agctcctggc agaagagagc          1500 
cagtctccct cactggataa aattgagtgt gtggaggggg aggggaagcc agcttatctg          1560 
taaggagtca tcctttccca ccctccatag tgctcacaca cagaccccaa gtcacttcat          1620 
cagccccaat ccaagagctg tccatcaaca cagcgcccat gcaatcctgt actttttata          1680 
ctaagctgac cacagcttgc atggccacct gcttcttttg tacatgttca tcttccaaaa          1740 
gcctggtacc ctaatacact atacactcct gaagccattc agtgcttgat aaacaagaca          1800 
gtgagcctga tatcctgaat gagcacctga tgggtggtgc ggtgagggct attgaataca          1860 
tccacaggga ctcctggtcc agaaatgggg catctactgc ctagagttca taaagtcact          1920 
tcaatagcat cactacgatg gaattgcaga agtataaata gcccaagagg aaagggaagc          1980 
taatgattgg aagttgtact cctaggaagc ttgaggttag acttccttat ccactcaaga          2040 
gtttctaggg gactggcagg gccccttctc ctcgctgcca agttgcaaaa ttgtgtggtc          2100 
acctccccca gcttccctcc ctcctatgcc ctcagtcctg gcctcctaga gccaggacaa          2160 
agccctcagg cagtgactgg gaggggaaca ggaggaggga cagagggatg gggaaggctg          2220 
cacaaaggaa ttcctcacac caagccccct gactgccagc tccagagagt aaagaagccg          2280 
acctcctctc cagctagctc actcgctcat cttcccacca tgactgtgct cgagccatag          2340 
cgcctctccc ggccttccaa gaggacccac acttcttcct gtaggtggca acagtgacac          2400 
ctgtttgacc agtgaggctg agccagggac tgcaagaggg aggaggcaga caactcggag          2460 
aggagctggg aggcagagct gcgggcttgc ttgctcactg tgtaaaaggt gtgagggctc          2520 
gggaaagct                                                                  2529 
<210> 4
<211> 158
<212> DNA
<213> mouse
<220>
<221> exon 
<222> 21..134
<223> exon 2
<400> 4
caaatgtcct tttcccccag gccttaacc atg gca gat tcc ccc ggc tgc tgc tcc atc      59
Met Ala Asp Ser Pro Gly Cys Cys Ser Ile 
1               5                  10
tgg gcc cgc tgc ctc cac tgc ctg tac agc tgc cac tgg agg aaa tat             107
Trp Ala Arg Cys Leu His Cys Leu Tyr Ser Cys His Trp Arg Lys Tyr
15                   20                 25
cct aaa cag aag atg caa acc agc aag gtggagaaag gatggggggg tgac              158
Pro Lys Gln Lys Met Gln Thr Ser Lys  
30                  35
<210> 5
<211> 159
<212> DNA
<213> mouse
<220>
<221> exon 
<222> 32..136
<223> exon 3
<400> 5
agctgagagc ttctctcctg ctcctttgca g tgc gac tgt atc tgg ttt ggc ctg ctc       58
Cys Asp Cys Ile Trp Phe Gly Leu Leu
1               5
ttc ctc acc ttc ctc ctg tcc ctg gga tgg ctg tac atc ggg ctc atc             106 
Phe Leu Thr Phe Leu Leu Ser Leu Gly Trp Leu Tyr Ile Gly Leu Ile 
10                  15                  20                   25
ctt ctc aat gat ctg cac aac ttc aat ga gtgtgtcatg taccacctcc ttcc           159 
Leu Leu Asn Asp Leu His Asn Phe Asn Glu 
30                  35 
<210> 6
<211> 155
<212> DNA
<213> mouse
<220>
<221> exon
<222> 26..119
<223> exon 4
<400> 6
aacatcttcc tttaccctcc tacag a ttc ctg ttc cgc cat tgg gga cac tgg atg gac    59 
Phe Leu Phe Arg His Trp Gly His Trp Met Asp
1               5                   10
tgg tcc ctg ata gtc ctg ctg gtc gtc tct ctc ctg gtc aca tat gca             107 
Trp Ser Leu Ile Val Leu Leu Val Val Ser Leu Leu Val Thr Tyr Ala
15                  20                  25 
tcc ttg cta ttg gttggtccag ggacatccgg cctaactccc acataa                     155 
Ser Leu Leu Leu 
30 
<210> 7
<211> 1552
<212> DNA
<213> mouse
<220>
<221> exon 
<222> 26..85
<223> exon 5
<220>
<221> exon
<222> 328..426
<223> exon 6
<220>
<221> exon
<222> 600..693
<223> exon 7
<220>
<221> exon
<222> 853..1001
<223> exon 8
<220>
<221> exon
<222> 1124..1206
<223> exon 9
<220>
<221> exon
<222> 1318..1468
<223> exon 10
<400> 7
aagtgcccct tctgtctgtt cccag ctc ctg ggc ctg ctc ctg caa ctc tgt gga cag      58
Leu Leu Gly Leu Leu Leu Gln Leu Cys Gly Gln
1               5                   10
cct ctg cat ctt cac agt ctc cac aag gtacagtgaa ttggcagtga tgaggagagg        115
Pro Leu His Leu His Ser Leu His Lys 
15                   20 
ggatgctggg tccagcaccc tgatggtcat ttgcttttct atccctgggg tcaagatcag           175
gacctgaaat ccagtacatg tttattgagt gaaagcatag tacatgcgtt caggaagggg           235
aagaatcctg tgtccacaga atgaagaggt agccccagtc accatgagcc taggctaaca           295
aggaaggccc attcattcgt ccctggcccc ag gtg ctg ctg ctc ctc att gta ctt cta     354
Val Leu Leu Leu Leu Ile Val Leu Leu
25
gtg gcc gcg gga ctg gtg ggc ctg gat atc caa tgg cgg cag gag tgg             402
Val Ala Ala Gly Leu Val Gly Leu Asp Ile Gln Trp Arg Gln Glu Trp
30                  35                  40                  45
cat agt tta cga ctg tca ctg cag gtgagtagct gacctccact atctatgtgg            456
His Ser Leu Arg Leu Ser Leu Gln
50 
gagccttggc ccatgcctat tctggaacat gacattgcct cctggtccta tgagactgca           516
gatctctctg gactgcagag aagggggagg cacaacacag aacaatagga agaagagcct           576 
tcctcaccag ctcttttcca cag gcc aca gcc cca ttc ctt cac att gga gca gtt gct   635
Ala Thr Ala Pro Phe Leu His Ile Gly Ala Val Ala
55                  60                  65
gga atc acc ttg ttg gcc tgg cct gtg gct gat acc ttc tac cgc atc             683
Gly Ile Thr Leu Leu Ala Trp Pro Val Ala Asp Thr Phe Tyr Arg Ile
70                  75                  80
cac cca aga g   gtgccaacat cagcccacat tcactctcac tggacaccag tgtctctgcc      743 
His Pro Arg Gly 
85
acccacccca ccccaccccc agtttcctgt acctgagctc tgccctctgc ccgtagagct           803 
ccaccttacc tgttgccttt cccctaagct tgtcctccac tttctacag gc ccc aag            860 
Pro Lys
gtt ctg cta ctg ttg cta ttt ttt gga gtc act ctg gtc atc tac ctg             908 
Val Leu Leu Leu Leu Leu Phe Phe Gly Val Thr Leu Val Ile Tyr Leu
90                   95                 100 
atg ccg ctg ctg ttc atc tct tcc ccc tgc atc atg aaa ctc aga gat             956 
Met Pro Leu Leu Phe Ile Ser Ser Pro Cys Ile Met Lys Leu Arg Asp 
105                 110                 115 
tta ccc ccc aag cct ggg ctg gtg gga cac cga ggg gcc ccc atg gtaagtggtg     1011 
Leu Pro Pro Lys Pro Gly Leu Val Gly His Arg Gly Ala Pro Met
120                 125                 130 
ggcagaaatc tagacaagtg aaaatgaatt tgctcctcta ggcttcagga tcaggtctga          1071
ggttcccagc cccgcccttc cctgctacct tctcaccacc tccctttcac ag ctg gcc          1129
Leu Ala
135
cct gag aat acc ctg atg tcc ctg agg aag aca gct gaa tgt gga gcg            1177
Pro Glu Asn Thr Leu Met Ser Leu Arg Lys Thr Ala Glu Cys Gly Ala
140                 145                 150
gct gtg ttt gag aca gat gtg atg gtc ag gtgatggagg gtgggaccta gggggttggt    1236
Ala Val Phe Glu Thr Asp Val Met Val Ser 
155                 160 
gggctggggg acacagtggg gggactcggg aaaagatgtc agctccagag ctttgtcccc          1296
tgacacttct tgtgcccaca g c tct gac gga gtc ccc ttt ctc atg cat gat gag cga  1354
Ser Asp Gly Val Pro Phe Leu Met His Asp Glu Arg
165                 170
ctg agc agg act acc aat gta gcc tct gtg ttt cca gag cga atc tca            1402 
Leu Ser Arg Thr Thr Asn Val Ala Ser Val Phe Pro Glu Arg Ile Ser
175                 180                 185                 190 
gcc cac agc agt gac ttc tcc tgg gct gaa ctg cag aga ctc aat gct            1450
Ala His Ser Ser Asp Phe Ser Trp Ala Glu Leu Gln Arg Leu Asn Ala
195                 200                 205
gga acc tgg ttc cta gag gtgaggacgc cagccaagat gaggccacta cctccttgac        1508
Gly Thr Trp Phe Leu Glu 
210  
actcagggca gagtccattt cagcagtatg cactcgctgc accc                           1552
<210> 8
<211> 358
<212> DNA
<213> mouse
<220>
<221> exon
<222> 116..337
<223> exon 11
<400> 8
ctgcagagca aattccaggc cagacaggac tgtagaaaac aaacaaacag atggcaagga            60 
ttgggagaaa accttgaggc ctcttgtgat gttgaaataa tttcctctct tatag agg            118 
Arg 
1 
caa cct ttc tgg ggg gcc aaa aag ctg tca ggc tct gat cgg aag gag             166 
Gln Pro Phe Trp Gly Ala Lys Lys Leu Ser Gly Ser Asp Arg Lys Glu
5                  10                  15 
gct gag aat cag acc ata cca gca tta gaa gaa cta ctg aag gaa gca             214 
Ala Glu Asn Gln Thr Ile Pro Ala Leu Glu Glu Leu Leu Lys Glu Ala 
20                 25                   30 
gca gct ctc aac ctt tcc atc atg ttt gac ttg cgc cga ccc cca aga             262 
Ala Ala Leu Asn Leu Ser Ile Met Phe Asp Leu Arg Arg Pro Pro Arg 
35                  40                   45 
aac cac aca tac tat gat act ttt gtg aat cag aca ctg gag gct gtg             310 
Asn His Thr Tyr Tyr Asp Thr Phe Val Asn Gln Thr Leu Glu Ala Val
50                  55                   60                  65 
ttg agt gca aac gtg tcc caa gct atg gtgatgtatc caggctccta a                 358
Leu Ser Ala Asn Val Ser Gln Ala Met 
70 
<210> 9
<211> 234
<212> DNA
<213> mouse
<220>
<221> exon
<222> 33..181
<223> exon 12
<400> 9
attaaatttt gttcattgcc cctgaaccac ag gtt ctt tgg ctc cca gat gaa gac cgt      59
Val Leu Trp Leu Pro Asp Glu Asp Arg
1               5 
gct aac gtg cag caa cgc gcc ccc aga atg cgc cag ata tat gga cat             107 
Ala Asn Val Gln Gln Arg Ala Pro Arg Met Arg Gln Ile Tyr Gly His
10                  15                  20                   25
cag gga ggc aat tgg act gag agg ccc cag ttt ctc aac ctc ccc tat             155 
Gln Gly Gly Asn Trp Thr Glu Arg Pro Gln Phe Leu Asn Leu Pro Tyr
30                  35                  40
caa gac ctg cca gca ttg gat atc aa gtgagtgtca aggaaaggaa taaaaggacc         211 
Gln Asp Leu Pro Ala Leu Asp Ile Lys 
45                   50
ccccaaggtt gactgtcaga aaa                                                   234 
<210> 10
<211> 1582
<212> DNA
<213> mouse
<220>
<221> exon
<222> 62..209
<223> exon 13
<220>
<221> exon
<222> 348..430
<223> exon 14
<220>
<221> exon
<222> 714..739
<223> exon 15
<220>
<221> exon
<222> 827..1496
<223> exon 16
<400> 10
gagtctcaga cgtgagctgg gcaaattctg tatgttcctc catttccccc cacttccaca            60
g g gcc ctg cac cag gat aat atc tca gtg aac ctg ttt gta gtg aac             107 
Ala Leu His Gln Asp Asn Ile Ser Val Asn Leu Phe Val Val Asn
1               5                  10                  15 
aag ccc tgg ctc ttc tcc ctg ctc tgg tgt gca ggg gtg gat tct gtc             155 
Lys Pro Trp Leu Phe Ser Leu Leu Trp Cys Ala Gly Val Asp Ser Val 
20                   25                 30 
acc acc aat gcc tgc cag ctg ctg caa cag atg cag aac ccc ctc tgg             203 
Thr Thr Asn Ala Cys Gln Leu Leu Gln Gln Met Gln Asn Pro Leu Trp 
35                  40                  45 
ctt ctt gtaaggactc tagaactgtc cctgcccctc atgtccaatc tcttatttcc              259 
Leu Leu 
tcttaaacct gtacccctcc atatttattt accccatatg ctactcttgg gagttctggc           319
cactgaaggg acttttccat ttccatag ccc cct caa aaa tac tta atg att              371 
Pro Pro Gln Lys Tyr Leu Met Ile 
50                  55 
tgg gtg atc acc gac tgt gcc tcc att ctg ctg ctt ttg agt atc ttc             419 
Trp Val Ile Thr Asp Cys Ala Ser Ile Leu Leu Leu Leu Ser Ile Phe 
60                  65                 70 
ctc ctc cga gg gtgagtgctt ttgccttggt ctcctgggca ctttcccggg                  470 
Leu Leu Arg Gly 
75 
ccccaagtaa aaaaggttga gtctgactgg agtgcactgc ccgggattaa gattttgtca           530 
ttgcaaattt cgagttttcc ttatctctat aaaatgtctt gaccctggcg aaagcagttt           590 
tggggaaccc tgggttggag agtcttgtaa caagttggtg gaacttgcaa cagaaaaaaa           650 
gaaagtctca atctctctct ctctctttct ctctctctct ttctctcccc cccccctctc           710 
tag g gga tgt gct aag aga aac aga aca g gtaagaatgc ccttgccctt cctttcttat    769 
Gly Cys Ala Lys Arg Asn Arg Thr Gly 
80                  85 
tttctcctca tttcccctgg cttcactccc tgtatgaccc gtctcttact tctctag gc           828
tta gaa aca gca gtg cta ctg acc aag atc aac aat ttc gcc tct gag             876
Leu Glu Thr Ala Val Leu Leu Thr Lys Ile Asn Asn Phe Ala Ser Glu
90                  95                  100
tga atgccgggcc caggccgcca ccagctgctg tctaaggcct gtgtgcactg                  929 
ttcaaaggga aggacaggag ctgaagtgga atgtcctaga atcaaatgtt tggaggaggg           989
agcattgcta acagaagatt ttgaactcag agggccctct gtccagatgg tgggcatgtc          1049 
tcaagctgcc atggaatttg ctgcctttgg tgtttgacat gaattagtcg gaaagacagt          1109
gactgacaag aagttactcc caaaatgaaa ttaaagcaag gaagtgagag agattgccaa          1169
gataatgcat taggcttgtg tgcacatgta cttggataga agaagcaggg tgtgtcaggg          1229
tgggatagct cagaatgatg actgaaggaa atttggccac aatggccttt ccggaagaac          1289
tcttaagatg ctgaagacag tccacactcc atgccttctc ttctcaccct cacacttcat          1349
cttcttttct gcctacaggc tgggagtgaa aaagctcatt tagcaatata atattgtgtc          1409
tatggtaggt ttttgttgtg agcaatgaat ggttcctgta tcttgcctgt taatctgtta          1469
ttcaatgaat ttttaatttg tcatttggtc acagtctaat catttctgtg ccggagttgg          1529
aagaatgctt tttccatctg gaactggatg taaaatgaca ttgagaggtc atc                 1582
【手続補正２】
【補正対象書類名】明細書
【補正対象項目名】００８２
【補正方法】削除
【補正の内容】
【手続補正３】
【補正対象書類名】明細書
【補正対象項目名】００８３
【補正方法】削除
【補正の内容】
【手続補正４】
【補正対象書類名】明細書
【補正対象項目名】００８４
【補正方法】削除
【補正の内容】
【手続補正５】
【補正対象書類名】明細書
【補正対象項目名】００８５
【補正方法】削除
【補正の内容】
【手続補正６】
【補正対象書類名】明細書
【補正対象項目名】００８６
【補正方法】削除
【補正の内容】
【手続補正７】
【補正対象書類名】明細書
【補正対象項目名】００８７
【補正方法】削除
【補正の内容】
【手続補正８】
【補正対象書類名】明細書
【補正対象項目名】００８８
【補正方法】削除
【補正の内容】
【手続補正９】
【補正対象書類名】明細書
【補正対象項目名】００８９
【補正方法】削除
【補正の内容】
【手続補正１０】
【補正対象書類名】明細書
【補正対象項目名】００９０
【補正方法】削除
【補正の内容】