Notice of Modification to the List of Permitted Food Enzymes to Enable the Use of Glucanase and Xylanase From Disporotrichum 
dimorphosporum  DXL -1 in Brewers’ Mash   
Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch     1 
  
Notice of Modification to the List of Permitted Food 
Enzymes  to Enable the Use of Glucanase and Xylanase 
From Disporotrichum dimorphosporum  DXL -1 in Brewers’ 
Mash  
Notice of Modification –  Lists of Permitted Food Additives  
Reference Number: [NOM/ADM -0057] 
 
 
 August 14, 2015   
Notice of Modification to the List of Permitted Food Enzymes to Enable the Use of Glucanase and Xylanase From Disporotrichum 
dimorphosporum  DXL -1 in Brewers’ Mash   
Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch     2 Summary  
 
Food additives are regulated in Canada under Marketing Authorizations  (MAs) issued by the 
Minister of Health and the Food and Drug Regulations. Approved food additives and their permitted conditions of use are set out in the 
Lists of Permitted Food Additives  that are 
incorporated by reference in the MA’s and publis hed on Health Canada’s website.  A petitioner 
can request that Health Canada approve a new additive or a new condition of use for an already approved food additive by f iling a food additive submission with the  Department's Food 
Directorate.  Health Canada uses this premarket approval process to determine whether the 
scientific data support the safety of food additives when used under specified conditions in foods sold in Canada.  
 Health Canada received a food additive submission seeking approval for the use of the enzymes xylanase and glucanase from Disporotrichum dimorphosporum  DXL -1 in brewers’ mash  at a 
level of use consistent with good manufacturing practice (GMP). Both xylanase and glucanase from Rasamsonia emersonii  (previous name: Talaromyces emersonii ) are already permitted for 
use in brewers’ mash.  However, D. dimorphosporum  DXL -1 has not yet  been approved as a 
source organism for any permitted food enzyme.  
 The results of Health Canada’s evaluation of available scientific data support the safety and efficacy of xylanase and glucanase from this new source organism when used as requested by th e 
petitioner.  Therefore, Health Canada has modified the List of Permitted Food Enzymes
 to extend 
the permitted sources of xylanase and glucanase to include D. dimorphosporum  DXL -1 by 
adding it as another permitted source organism for item numbers G.2 and X.1 of the list as shown below.   
 
Modification to the List of Permitted Food Enzymes  
 
Item 
No. Column 1  
Additive  Column 2  
Permitted Source  Column 3  
Permitted in or 
upon  Column 4  
Maximum Level of Use and Other 
Conditions  
G.2 Glucanase  Disporotrichum  
dimorphosporum DXL -1; 
Rasamsonia emersonii  
(previous name: 
Talaromyces emersonii ) (1) 
 Brewers' Mash  (1)  
Good Manufacturing Practice  
X.1 Xylanase  Disporotrichum  
dimorphosporum DXL -1; 
Rasamsonia emersonii  
(previous name: 
Talaromyces emersonii ) (1) 
 Brewers' Mash  (1)  
Good Manufacturing Practice  
  
Notice of Modification to the List of Permitted Food Enzymes to Enable the Use of Glucanase and Xylanase From Disporotrichum 
dimorphosporum  DXL -1 in Brewers’ Mash   
Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch     3 Rationale  
 
Health Canada’s Food Directorate completed a pre -market safety assessment of the requested use 
of glucanase  and xylanase obtained from D. dimorphosporum DXL -1.  The assessment 
considered microbiological, toxicological, chemical and technical aspects of these additives, and 
found that the requested uses are acceptable from a food safety perspective. Therefore, t he 
Department has enabled the requested uses of glucanase and xylanase obtained from D. dimorphosporum DXL -1 by modifying the List of Permitted Food Enzymes
 as describ ed in the 
above table.  
 
Other Relevant Information  
 
The Food and Drug Regulations require that food additives such as glucanase and xylanase 
obtained from D. dimorphosporum DXL -1, which do not have specifications set out in the 
Regulations, meet the food- grade specifications set out in the most recent edition of the Food 
Chemicals Codex (FCC). The FCC is a compendium of standards for purity and identity for food ingredients, including food additives, which is published by the United States Pharmacopeial Convention. 
 
Implementation and Enforcement  
 
The above modification came into force August 14, 2015, the day it was published in the  List of 
Permitted Food Enzymes . 
 The Canadian Food Inspection Agency is responsible for the enforcement of the Food and Drugs Act and its associated regulations with res pect to foods.  
 
Contact Information  
 
Health Canada's Food Directorate is committed to reviewing any new scientific information on 
the safety in use of any permitted food additive , including glucanase and xylanase obtained from 
D. dimorphosporum DXL -1. Anyone wishing to submit new scientific information on the use of 
this additive or to submit any inquiries may do so in writing, by regular mail or electronically.  If 
you wish to contact the Food Directorate elec tronically, please use the word s “glucanase  and 
xylanase obtained from D. dimorphosporum DXL -1" in the subject line of your e -mail.  
 Bureau of Chemical Safety , Food Directorate
 
251 Sir Frederick Banting Driveway  
Tunney’s Pasture, PL: 2202C  
Ottawa, Ontario K1A 0L2  
E-mail: bcs -bipc@hc -sc.gc.ca