EN    EN    
  
  EUROPEAN
COMMISSION   
Brussels, XXX
[…](2014) XXX draft    
ANNEXES 1 to 6
ANNEXES
to the 
Commission Regulation (EU) No...
of XXX
amendin g, for the purposes of its adaptation  to technical and scientific pro gress, 
Regulation (EC) No 1272/2008 of the European  Parliament and of the Council on 
classification, labelling and pack aging of substances and mixtures    
(Text with EEA relevance) 
  
ANNEX I  
 
Annex I to Regulation (EC) No 1272/2008 is amended as follows: 
 
A. Part 1 is amended as follows: 
(1) The title of section 1.1.3.4 is replaced by the following: 
'Interpolation within one hazard category ' 
(2) Section 1.3.6 is replaced by the following:  
'Substances or mixtures classified as  corrosive to metals but not clas sified as corrosive to skin or 
as causing serious eye damage  
Substances or mixtures classified as corrosive to me tals but not classified as corrosive to skin or as 
causing serious eye damage which are in the finish ed state as packaged for consumer use do not 
require on the label the hazard pictogram GHS05.' 
B. Part 2 is amended as follows: 
(1) Section 2.1.3 is replaced by the following: 
'Hazard Communication  
Label elements shall be used for substances, mixtures or articles meeting the criteria for 
classification in this hazard cl ass in accordance with Table 2.1.2.   
 Table 2.1.2: Label elements for explosives 
Classification Unstable Explosive Division 1.1 Division 1.2 Division 1.3 Division 1.4 Division 1.5 Division 1.6 
GHS Pictograms 
 
  
  
  
    
Signal Word Danger Danger Danger Danger Warn ing Danger No signal word 
Hazard Statement H200: Unstable 
Explosive H201: Explosive; 
mass explosion 
hazard H202: Explosive; 
severe projection 
hazard H203: Explosive; 
fire, blast or 
projection hazard H204: Fire or 
projection hazardH205: May mass 
explode in fire No hazard 
statement 
Precautionary Statement PreventionP201 
P250 P280 P210 
P230 P234 P240 
P250 
P280 P210 
P230 P234 P240 
P250 
P280 P210 
P230 P234 P240 
P250 
P280 P210 
P234 P240 P250 
P280 P210 
P230 P234 P240 
P250 
P280 No precautionary 
statement 
Precautionary 
Statement Response P370+P372+P380+
P373 P370+P372+P380+
P373 P370+P372+P38
0+P373 P370+P372+P380+
P373 P370+P372+P380
+P373 
 
P370+P380+P375P370+P372+P380
+P373 
 No precautionary 
statement 
Precautionary Statement Storage P401 P401 P401 P401 P401 P401 No precautionary 
statement 
Precautionary 
Statement Disposal P501 P501 P501 P501 P501 P501 No precautionary 
statement 
 
NOTE 1: Unpackaged explosives or explosives repackaged in pack aging other than the original or  similar packaging shall include all of the following 
label elements:  
 (a) the pictogram: exploding bomb;  
(b) the signal word ‘Danger’; and (c) the hazard statement: ‘expl osive; mass explosion hazard’ 
unless the hazard is shown to correspond to  one of the hazard categories in Table 2.1.2, in which case the corresponding symbol , the signal word 
and/or the hazard statem ent shall be assigned. 
NOTE 2: Substances and mixt ures, as supplied, with a positive result in Test Series 2 in Part I, Section 12, of the UN, Manual of Tests and Criteria, 
which are exempted from classification as explosives (based on a ne gative result in Test Series 6 in Part I, Section 16 of the UN RTDG, Manual of 
Tests and Criteria,) still have explosive properties. The user sha ll be informed of these intrinsic explosive properties becaus e they have to be considered 
for handling – especially if the substance or  mixture is removed from its packaging or is repackaged – and for storage. For thi s reason, the explosive 
properties of the substance or mixture shall be communicated in  Section 2 (Hazards id entification) and Section 9 (Physical and chemical properties) of 
the Safety Data Sheet and other sections of  the Safety Data Sheet, as appropriate.'  
 (2) In section 2.1.4, Figure 2.1.3 is replaced by the following: 
'Figure 2.1.3 
Procedure for assignment to a division in th e class of explosives (Class 1 for transport) 
 
 
No 
No ARTICLE OR SUBSTANCE/MIXTURES PROV ISIONALLY ACCEPTED IN THIS CLASS
(from figure 2.1.2)
Yes 
TEST SERIES 5Yes
YesNo 
No
No
NoIs the 
article a candidate 
for Division 1.6?  
TEST SERIES 7 
Is it an 
extremely insensitive  
article?  Is the
substance/mixture a 
candidate for Division 
1.5? Package the 
substance/ 
mixture TEST SERIES 6 
Is the 
result a mass 
explosion?  
Is the 
major hazard that 
from dangerous 
projections? 
Is 
the major 
hazard radiant heat 
and/or violent burning 
but with no dangerous blast 
or projection 
hazard? Would
the hazard 
hinder fire-fighting in the 
immediate 
vicinit y?
Are there 
hazardous effects 
outside the 
package? 
Is the
substance/mixture or article 
manufactured with the view of 
producing a practical explosive 
or pyrotechnic 
effect?
Is the 
product an article 
excluded by definition? 
(see 2.1.1.1 (b)) 
NOT AN 
EXPLOSIVE DIVISION 
1.6 DIVISION 
1.5 DIVISION 1.4 
Compatibility 
group SDIVISION 1.4 
Compatibility groups 
other than SDIVISION 
1.3 DIVISION 
1.2 DIVISION
1.1 Yes 
YesYesYesYes
No
No 
Yes Yes Yes No
NoNo 
Is it a
very insensitive 
explosive substance /mixture 
with a mass explosion 
hazard? 
6 
 ' 
(3) In section 2.2.3, Table 2.2.3 is replaced by the following: 
'Table 2.2.3 
Label elements for flammable gases (i ncluding chemically unstable gases) 
Flammable gas Chemically unstable gas 
Classification Category 1 Category 2 Category A Category B 
GHS Pictogram 
 No pictogram No additional 
pictogram No additional 
pictogram 
Signal Word Danger Warning No additional 
signal word No additional 
signal word 
Hazard Statement H220: Extremely 
flammable gas H221: Flammable 
gas Additional hazard 
statement  H230: 
May react 
explosively even in 
the absence of air Additional hazard 
statement  H231: 
May react 
explosively even in 
the absence of air at 
elevated pressure 
and/or temperature
Precautionary Statement Prevention P210 P210 P202 P202 
Precautionary 
Statement Response P377 
P381 P377 
P381   
Precautionary 
Statement Storage P403 P403   
Precautionary 
Statement Disposal     
' 
(4) Section 2.3.2.1 is replaced by the following: 
'2.3.2.1. Aerosols shall be classified in one of the three categories of this hazard class, 
depending on their flammable properties and their heat of combustion. They shall be 
considered for classification in Category 1 or 2 if they contain more than 1% components (by 
mass) which are classified as flammable according to  the following criteria set out in this Part: 
− Flammable gases (s ee section 2.2);  
7 
 − Liquids with a flash point ≤ 93 ° C, which includes Flammable Liquids according to 
section 2.6; 
− Flammable solids (see section 2.7); 
or if their heat of comb ustion is at least 20 kJ/g. 
NOTE 1: Flammable components do not cover pyrophoric, self-heating or water-reactive 
substances and mixtures because such com ponents are never used as aerosol contents. 
NOTE 2: Aerosols do not fall additionally with in the scope of sections 2.2 (flammable 
gases), 2.5 (gases under pressure), 2.6 (fla mmable liquids) and 2.7 (flammable solids). 
Depending on their contents, aerosols may howe ver fall within the scope of other hazard 
classes, including their labelling elements.' 
8 
 (5) In section 2.3.2, Figure 2.3.1 (a) is replaced by the following:  
'Figure 2.3.1(a) for aerosols  
AEROSOL   
   
   
   
Does it contain ≤ 1% flammable 
components (by mass) and  does it have a 
heat of combustion < 20 kJ/g?   
Category 3 
 
No pictogram 
 
Warning 
 
   
   
   
Does it contain ≥ 85% flammable 
components (by mass) and does it have a 
heat of combustion ≥ 30 kJ/g?  Category 1 
 
 
 
Danger 
   
   
   
For spray aerosols, go to decision logic 
2.3.1(b) 
 
For foam aerosols, go to decision logic 
2.3.1(c)' '  
    
 NO 
 NO YES
YES 
9 
 (6) In section 2.3.3, the heading of Table 2.3.1 is replaced by the following: 
'Label elements for aerosols ' 
(7) In section 2.5.3, Table 2.5.2 is replaced by the following: 
'Table 2.5.2 
Label elements for gases under pressure 
Classification Compressed gas Liquefied gas Refrigerated 
liquefied gas Dissolved gas 
GHS Pictograms 
 
  
  
  
Signal Word Warning Warning Warning Warning 
Hazard 
Statement H280: Contains 
gas under 
pressure; may 
explode if 
heated H280: Contains 
gas under 
pressure; may 
explode if heatedH281: Contains 
refrigerated gas; 
may cause 
cryogenic burns 
or injury H280: Contains 
gas under 
pressure; may 
explode if heated
Precautionary Statement Prevention   P282  
Precautionary 
Statement Response   P336+P315  
Precautionary 
Statement Storage P410 + P403 P410 + P403 P403 P410 + P403 
Precautionary 
Statement 
Disposal     
' 
(8) In section 2.8.3, Table 2.8.1 is replaced by the following: 
'Table 2.8.1 
Label elements for self-reactive substances and mixtures  
10 
  
Classification Type A Type B Type C & D Type E & F Type G 
GHS Pictograms 
 
 
 
 
  
Signal Word Danger Danger Danger Warning 
Hazard 
Statement H240: 
Heating may 
cause an 
explosion H241: 
Heating may 
cause a fire or 
explosion H242: 
Heating may 
cause a fire H242: Heating 
may cause a 
fire 
Precautionary Statement Prevention P210 
P234 P235 P240 P280 P210 
P234 P235 P240 P280 P210 
P234 P235 P240 P280 P210 
P234 P235 P240 P280 There are no 
label 
elements 
allocated to 
this hazard 
category 
Precautionary Statement Response P370+P372+
P380+P373 PP370 + 
P380+P375 
[+P378]
1 
 P370 + P378 P370 + P378  
Precautionary 
Statement 
Storage P403  
P411 
P420 P403  
P411 
P420 P403  
P411 
P420 P403  
P411 
P420  
Precautionary 
Statement Disposal P501 P501 P501 P501  
1 See introductory sentence to Annex IV for details on the use of square brackets. 
' 
(9) In section 2.8.4, Figure 2.8.1 is replaced by the following: 
'Figure 2.8.1 
Self-reactive substances and mixtures 
11 
 ' 4.2  Yes, slowly
4.3  No  
14.1 Yes  Box 14
Test H
Box 15SUBSTANCE/MIXTURE
6.1 Yes  Box 6 
Test D 
6.2 No  
7.2 Medium  
7.3 Low  
7.4 None  Box 7 
Test E
7.1  
Violent  
10.1 Yes  Box 10 
Test G 
10.2 No  3.2  Yes, slowly  
3.3  No3.1  
Yes, rapidly  2.1 Yes  2.2 No  
 1.1 Yes  
1.2 Partial1.3 No
4.1  
Yes, rapidly   
11.2 No
12.2 Low12.3 None  
13.1 Low  5.1 
Yes, rapidly
5.2 Yes, slowly5.3 No
Box 8
Test E
8.1  
Violent  
8.2 Medium  
8.3 Low  
8.4 None   
9.2 MediumBox 9
Test E
9.1 
Violent
11.1 Yes  Box 11
Box 12 
Test F 
Type A           Type B  Type C  Type D Type E Type F  Does it propagate 
a detonation? 
Can it  
detonate as 
packaged? 
Can it 
propagate a 
deflagration?  Box 1 
Test A 
Box 2 
Test B 
Box 3 
Test C
Can it 
propagate a 
deflagration? 
Can it 
propagate a 
deflagration?  Box 4
Test C
Box 5
Test C
Does it 
deflagrate rapidly 
in package? 
What is 
the effect of heating 
under defined 
confinement? 
What is 
the effect of heating 
under defined 
confinement? 
What is 
the effect of heating 
under defined 
confinement? 
Can it explode as 
packaged? 
What is 
its explosive 
power? 12.1Not low
Box 16
16.1 Yes  
Type GIs the substance a solid?14.2 No  Box 13
Test E
What is the effect 
of heating it under defined
 confinement? 
Is the SADT <60°C 
 in a 50 kg package? 
Is a diluent 
with a boiling point of 
< 150 °C used? 
16.2 No  13.2 None  
15.2 No  9.3 Low
9.4 None
15.1 YesPackaged 
in packages of more 
than 400 kg/450 l  or to be 
considered for 
exemption?  
12 
 (10) In section 2.9.3, Table 2.9.2 is replaced by the following: 
'Table 2.9.2 
Label elements for pyrophoric liquids 
Classification Category 1 
GHS Pictogram 
 
Signal Word Danger 
Hazard Statement H250: Catches fire 
spontaneously if exposed to air 
Precautionary Statement 
Prevention P210 
P222 
P231+P232 
P233 P280 
Precautionary Statement Response P302 + P334 
P370 + P378 
Precautionary Statement Storage  
Precautionary Statement 
Disposal  
' 
(11) In section 2.10.3, Table 2.10.2 is replaced by the following: 
'Table 2.10.2 
Label elements for pyrophoric solids 
Classification Category 1 
GHS Pictogram 
 
Signal Word Danger  
13 
 Hazard Statement H250: Catches fire 
spontaneously if exposed to air 
Precautionary Statement Prevention P210 
P222 
P231+P232 
P233 P280 
Precautionary Statement Response P302+P335+P334 
P370 +P378 
Precautionary Statement Storage  
Precautionary Statement 
Disposal  
' 
(12) In section 2.11.3, Table 2.11.2 is replaced by the following: 
'Table 2.11.2 
Label elements for self-heating substances and mixtures 
Classification Category 1 Category 2 
GHS Pictograms 
 
  
Signal Word Danger Warning 
Hazard Statement P251: Self-heating; 
may catch fire P252: Self-heating in 
large quantities; may 
catch fire 
Precautionary Statement Prevention P235  
P280 P235  
P280 
Precautionary Statement Response   
Precautionary 
Statement Storage P407 
P413 P420 P407 
P413 P420  
14 
 Precautionary 
Statement Disposal   
' 
(13) In section 2.12.3, Table 2.12.2 is replaced by the following: 
'Table 2.12.2 
Label elements for substances and mixtures which 
in contact with water emit flammable gases 
Classification Category 1 Category 2 Category 3 
GHS Pictograms 
 
  
  
Signal Word Danger Danger Warning 
Hazard Statement H260: 
In contact with 
water releases 
flammable gases 
which may ignite 
spontaneously H261: 
In contact with 
water releases 
flammable gases H261: 
In contact with 
water releases 
flammable gases 
Precautionary Statement Prevention P223 
P231 + P232 
P280 P223 
P231 + P232 
P280 P231 + P232 
P280 
Precautionary 
Statement Response P302+P335 + P334
P370 + P378 P302+P335 + P334
P370 + P378 P370 + P378 
Precautionary 
Statement Storage P402 + P404 P402 + P404 P402 + P404 
Precautionary 
Statement Disposal P501 P501 P501 
' 
(14) In section 2.13.3, Table 2.13.2 is replaced by the following: 
'Table 2.13.2 
Label elements for oxidising liquids  
15 
 Classification Category 1 Category 2 Category 3 
GHS Pictograms 
 
  
  
Signal Word Danger Danger Warning 
Hazard Statement H271:May cause fire 
or explosion; strong 
oxidiser H272: May intensify 
fire; oxidiser H272: May intensify 
fire; oxidiser 
Precautionary Statement Prevention P210 
P220 P280 P283 P210 
P220 P280 P210 
P220 P280 
Precautionary 
Statement Response P306 + P360 
P371 + P380 + P375
P370 + P378 P370 + P378 P370 + P378 
Precautionary 
Statement Storage P420   
Precautionary 
Statement Disposal P501 P501 P501 
' 
(15) In section 2.14.2.1, the introductory sent ence is replaced by the following: 
'An oxidising solid shall be classified in one of  the three categories for this class using test 
O.1 in Part III, sub-section 34.4.1 or test O .3 in Part III, sub-section 34.4 3 of the UN 
Recommendations on the Transpor t of Dangerous Goods, Manual of Tests and Criteria in 
accordance with Table 2.14.1:' 
(16) In section 2.14.2.1, Table 2.14.1 is replaced by the following: 
'Table 2.14.1: Criteria for oxidising solids 
Category Criteria using test O.1 Criteria using test O.3 
1 Any substance or mixture which, in the 
4:1 or 1:1 sample-to-cellulose ratio (by mass) tested, exhibits a mean burning time less than the mean burning time of a 3:2 mixture, (by mass), of potassium bromate and cellulose. Any substance or mixture which, in the 
4:1 or 1:1 sample-to-cellulose ratio (by mass) tested, exhibits a mean burning rate greater than the mean burning rate of a 3:1 mixture (by mass) of calcium peroxide and cellulose. 
2 Any substance or mixture which, in the Any substance or mixture which, in the  
16 
 4:1 or 1:1 sample-to-cellulose ratio (by 
mass) tested, exhibits a mean burning time equal to or less than the mean burning time of a 2:3 mixture (by mass) of potassium bromate and cellulose and the criteria for Category 1 are not met. 4:1 or 1:1 sample-to-cellulose ratio (by 
mass) tested, exhibits a mean burning rate equal to or gr eater than the mean 
burning rate of a 1:1 mixture (by mass) of calcium peroxide and cellulose and the criteria for Category 1 are not met. 
3 Any substance or mixture which, in the 
4:1 or 1:1 sample-to-cellulose ratio (by mass) tested, exhibits a mean burning time equal to or less than the mean burning time of a 3:7 mixture (by mass) of potassium bromate and cellulose and the criteria for Categories 1 and 2 are not met. Any substance or mixture which, in the 
4:1 or 1:1 sample-to-cellulose ratio (by mass) tested, exhibits a mean burning rate equal to or gr eater than the mean 
burning rate of a 1:2 mixture (by mass) of calcium peroxide and cellulose and the criteria for Categories 1 and 2 are not met. 
' 
(17) In section 2.14.2.1, in Note 1 to Table 2.14.1, ‘(BC Code, Annex 3, Test 5)’ is 
replaced by '(IMSBC Code (International Maritime Solid Bulk Cargoes Code, IMO), 
Appendix 2, Section 5)'. 
(18) In section 2.14.3, Table 2.14.2 is replaced by the following: 
'Table 2.14.2 
Label elements for oxidising solids 
 Category 1 Category 2 Category 3 
GHS Pictograms 
 
  
  
Signal Word Danger Danger Warning 
Hazard Statement H271: May cause fire 
or explosion; strong 
oxidiser H272: May intensify 
fire; oxidiser H272: May intensify 
fire; oxidiser 
Precautionary Statement Prevention P210 
P220 P280 P283 P210 
P220 P280 P210 
P220 P280 
Precautionary Statement Response P306 + P360 
P371 + P380 + P375
P370 + P378 P370 + P378 P370 + P378  
17 
 Precautionary 
Statement Storage P420   
Precautionary 
Statement Disposal P501 P501 P501 
' 
(19) In section 2.15.3, Table 2.15.1 is replaced by the following: 
'Table 2.15.1 
Label elements for organic peroxides 
Classification Type A Type B Type C & D Type E & F Type G 
GHS Pictograms 
 
 
 
 
Signal Word Danger Danger Danger Warning 
Hazard 
Statement H240: 
Heating may 
cause an 
explosion H241: 
Heating may 
cause a fire or 
explosion H242: 
Heating may 
cause a fire H242: Heating 
may cause a fire 
Precautionary Statement Prevention P210 
P234 P235 P240 P280 P210 
P234 P235 P240 P280 P210 
P234 P235 P240 P280 P210 
P234 P235 P240 P280 There are no 
label 
elements 
allocated to 
this hazard 
category 
Precautionary Statement Response P370+P372+
P380+P373 P370+P380+
P375[+P378]
1P370+P378 P370+P378  
Precautionary Statement Storage P403 
P410  P411 P420 P403 
P410  P411 P420 P403 
P410  P411 P420 P403 
P410  P411 P420  
                                                            
1 See introductory sentence to Annex IV fo r details on the use of square brackets.  
18 
 Precautionary 
Statement Disposal P501 P501 P501 P501  
' 
(20) In section 2.15.4, Figure 2.15.1 is replaced by the following: 
'Figure 2.15.1 
Organic Peroxides  
19 
 '4.2  Yes, slowly
4.3  No  
14.1 Yes  Box 14
Test H
Box 15  ORGANIC PEROXIDE
6.1 Yes  Box 6 
Test D 
6.2 No  
7.2 Medium  
7.3 Low  
7.4 None  Box 7 
Test E
7.1  
Violent  
10.1 Yes  Box 10 
Test G
10.2 No  3.2  Yes, slowly  
3.3  No3.1  
Yes, rapidly  2.1 Yes  2.2 No  
 1.1 Yes  
1.2 Partial1.3 No
4.1  
Yes, rapidly   
11.2 No
12.2 Low12.3 None  
13.1 Low  5.1 
Yes, rapidly
5.2 Yes, slowly5.3 No
Box 8
Test E
8.1  
Violent  
8.2 Medium  
8.3 Low  
8.4 None   
9.2 MediumBox 9
Test E
9.1 
Violent
11.1 Yes  Box 11
Box 12 
Test F 
Type A           Type B  Type C  Type D Type E Type F  Does it propagate 
a detonation? 
Can it  
detonate as 
packaged? 
Can it 
propagate a 
deflagration?  Box 1 
Test A 
Box 2 
Test B
Box 3 
Test C
Can it 
propagate a 
deflagration? 
Can it 
propagate a 
deflagration?  Box 4
Test C
Box 5
Test C
Does it 
deflagrate rapidly 
in package? 
What is the effect 
 of heating under 
defined confinement? 
What is the effect 
 of heating under 
defined confinement?
What is the effect 
 of heating under 
defined confinement?
Can it explode as 
packaged? 
What is 
its explosive 
power? 12.1Not low
Box 16
16.1 Yes  
Type GIs the substance a solid?14.2 No  Box 13
Test E
What is the effect 
of heating it under defined
 confinement? 
Is the SADT <60°C 
 in a 50 kg package? 
Is a diluent 
with a boiling point of 
< 150 °C used?
16.2 No  13.2 None  
15.2 No  9.3 Low
9.4 None
15.1 YesPackaged 
in packages of more 
than 400 kg/450 l  or to be 
considered for 
exemption?  
20 
 C. Part 3 is amended as follows: 
(1) In section 3.1.2.1, the first sentence is replaced by the following: 
'Substances can be allocated to one of f our hazard categories based on acute toxicity 
by the oral, dermal or inhalation route acco rding to the numeric criteria shown in 
Table 3.1.1.' 
(2) In section 3.1.2.3.2, the first sentence  is replaced by the following:  
'Of particular importance in classifying fo r inhalation toxicity is the use of well 
articulated values in the highest h azard categories for dusts and mists.' 
(3) In section 3.1.3.6.1, point (a) is replaced by the following:   
'include ingredients with a known acute to xicity, which fall into any of the acute 
hazard categories shown in Table 3.1.1;' 
(4) Chapter 3.2 is replaced by the following: 
'3.2. Skin Corrosion/Irritation  
3.2.1. Definitions and general considerations 
3.2.1.1. Skin Corrosion means the production of irre versible damage to the skin; namely, 
visible necrosis through the epidermis and into the derm is, following the application 
of a test substance for up to 4 hours. Co rrosive reactions are typified by ulcers, 
bleeding, bloody scabs, and, by the end of observation at 14 days, by discolouration 
due to blanching of the skin, complete ar eas of alopecia, and scars. Histopathology 
shall be considered to eval uate questionable lesions. 
Skin Irritation means the produc tion of reversible damage to the skin following the 
application of a test substance for up to 4 hours. 
3.2.1.2 In a tiered approach, empha sis shall be placed upon exis ting human data, followed by 
existing animal data, followed by in vitro  data and then other sources of information. 
Classification results directly when the data satisfy the criteria. In some cases, classification of a substance or a mixture is made on the basis of the weight of 
evidence within a tier. In a total weight  of evidence approach all available 
information bearing on the determination of  skin corrosion/irritation is considered 
together, including the results of appropriate validated  in vitro  tests, relevant animal 
data, and human data such as epidemio logical and clinical  studies and well  
21 
 documented case reports and observations (see Annex I, Part  1, sections 1.1.1.3, 
1.1.1.4 and 1.1.1.5). 
3.2.2. Classification criteria for substances 
Substances shall be allocated to one of the following two categories within this hazard 
class: 
(a) Category 1 (skin corrosion) 
This category is further subdivided in thr ee sub-categories (1A, 1B, 1C). Corrosive 
substances shall be classified in Categor y 1 where data is not sufficient for sub-
categorisation. When data are sufficient, subs tances shall be classified in one of the 
three sub-categories 1A, 1B, or 1C (see Table 3.2.1.)  
(b) Category 2 (skin irritation) (see Table 3.2.2). 
3.2.2.1  Classification based on standard animal test data  
3.2.2.1.1  Skin corrosion 
3.2.2.1.1.1  A substance is corrosive to skin when  it produces destruction of skin tissue, 
namely, visible necrosis through the epid ermis and into the dermis in at least 
one tested animal after exposure for up to 4 hours.  
3.2.2.1.1.2  Corrosive substances shall be classi fied in Category 1 where data is not 
sufficient for sub-categorisation. 
3.2.2.1.1.3  When data are sufficient substances sha ll be classified in one of the three sub-
categories 1A, 1B, or 1C in accordance with the criteria in Table 3.2.1. 
3.2.2.1.1.4  Three sub-categories are provided within the corrosion category: sub-
category 1A – where corrosive responses  are noted following up to 3 minutes 
exposure and up to 1 hour observation;  sub-category 1B – where corrosive 
responses are described following exposure greater than 3 minutes and up to 1 hour and observations up to 14 days; and sub-category 1C – where corrosive responses occur after e xposures greater than1 hour  and up to 4 hours and 
observations up to 14 days. 
Table 3.2.1: Skin corrosion category and sub-categories
 
Category Criteria  
22 
 Category 11 Destruction of skin tissue, namely, visible necrosis through the epidermis 
and into the dermis, in at least one tested animal after exposure ≤ 4 h  
Sub-category 
1A Corrosive responses in at leas t one animal following exposure ≤ 3 min 
during an observation period ≤ 1 h  
Sub-category 
1B Corrosive responses in at least one animal following exposure > 3 min and 
≤ 1 h and observations ≤ 14 days  
Sub-category 
1C Corrosive responses in at least one  animal after exposures > 1 h and ≤ 4 h 
and observations ≤ 14 days 
1 See the conditions for the use of Category 1 in the introductory pa ragraph of section 3.2.2. 
3.2.2.1.1.5  The use of human data is discusse d in sections 3.2.1.2 and 3.2.2.2 and also in 
sections 1.1.1.3, 1.1.1.4 and.1.1.1.5. 
3.2.2.1.2  Skin irritation 3.2.2.1.2.1  A substance is irritant to skin when it produces reversible damage to the skin 
following its application for up to 4 hours. The major criterion for the irritation 
category is that at least 2 of 3 te sted animals have a mean score of ≥ 2.3 and ≤ 
4.0. 
3.2.2.1.2.2  A single irritation category (Category 2) is presented in Table 3.2.2, using the 
results of animal testing. 
3.2.2.1.2.3  Reversibility of skin lesions is also considered in evaluating irritant responses. 
When inflammation persists to the end of  the observation period in 2 or more 
test animals, taking into consideration alopecia (lim ited area), hyperkeratosis, 
hyperplasia and scaling, then a material sh all be considered to be an irritant. 
3.2.2.1.2.4  Animal irritant responses within a test can be variable, as they are with 
corrosion. A separate irritant criteri on accommodates cases where there is a 
significant irritant response but less than the mean score criterion for a positive test. For example, a test material might be designated as an irritant if at least 1 
of 3 tested animals shows a very el evated mean score throughout the study, 
including lesions persisti ng at the end of an obser vation period of normally 14 
days. Other responses could also fulfil th is criterion. However, it should be 
ascertained that the responses are the result of chemical exposure. 
Table 3.2.2 
Skin irritation category 
a  
23 
 Category Criteria 
Irritation 
(Category 2)  (1) Mean score of ≥ 2,3  and ≤ 4,0 for erythema/eschar or for oedema 
in at least 2 of 3 tested anim als from gradings at 24, 48 and 
72 hours after patch removal or, if reactions are delayed, from grades on 3 consecutive days after the onset of skin reactions; or 
 (2) Inflammation that persists to the end of the observation period 
normally 14 days in at least 2 an imals, particularly taking into 
account alopecia (limited area), hype rkeratosis, hyperplasia, and 
scaling reactions; or 
 (3) In some cases where there is pronounced variability of response 
among animals, with very definite positive effects related to chemical exposure in a single an imal but less than the criteria 
above . 
a) Grading criteria are understood as de scribed in Regula tion (EC) No 440/2008 
3.2.2.1.2.6  The use of human data is discusse d in sections 3.2.1.2 and 3.2.2.2 and also in 
sections 1.1.1.3, 1.1.1.4 and 1.1.1.5.  
3.2.2.2.   Classification in a tiered approach 3.2.2.2.1  A tiered approach to the evaluation of initial information shall be considered, 
where applicable, recognising that not all elements may be relevant.  
3.2.2.2.2  Existing human and animal data includi ng information from single or repeated 
exposure shall be the first line of evalua tion, as they give information directly 
relevant to effects on the skin. 
3.2.2.2.3  Acute dermal toxicity data may be us ed for classification. If a substance is 
highly toxic by the dermal route, a sk in corrosion/irritation study is not 
practicable since the amount  of test substance to be applied considerably 
exceeds the toxic dose and, consequently, re sults in the death of the animals. 
When observations are made of skin corrosion/irritation in acute toxicity 
studies and are observed up through the li mit dose, these data may be used for 
classification, provided that the dilu tions used and species tested are 
equivalent. Solid substances (powders) ma y become corrosive or irritant when 
moistened or in contact with moist skin or mucous membranes. 
3.2.2.2.4  In vitro alternatives that have been  validated and accepted shall be used to 
make classification decisions.  
24 
 3.2.2.2.5  Likewise, pH extremes like ≤ 2 and ≥ 11,5 may indicate the potential to cause 
skin effects, especially when associat ed with significant acid/alkaline reserve 
(buffering capacity). Generally, such substances are expected to produce 
significant effects on the sk in. In the absence of any other information, a 
substance is considered as corrosive to skin (Skin Corrosion Category 1) if it 
has a pH ≤ 2 or a pH ≥ 11,5. However, if considera tion of acid/alkaline reserve 
suggests the substance may not  be corrosive despite th e low or high pH value, 
this needs to be confirmed by other data, preferably by data from an 
appropriate validated in vitro test. 
3.2.2.2.6  In some cases, sufficient information ma y be available from structurally related 
substances to make cl assification decisions. 
3.2.2.2.7.  The tiered approach provides guida nce on how to organize existing 
information on a substance and to make a weight of evidence decision about 
hazard assessment and hazard classification.   
Although information might be gained  from the evaluation of single 
parameters within a tier (see sectio n 3.2.2.2.1.), consideration shall be given to 
the totality of existing information and making an overall weight of evidence 
determination. This is especially true when there is conflict in information available on some parameters.  
3.2.3. Classification criteria for mixtures 
3.2.3.1. Classification of mixtures when data ar e available for the complete mixture 
3.2.3.1.1. The mixture shall be classified using the criteria for subs tances, taking into 
account the tiered approach to eval uate data for this hazard class. 
3.2.3.1.2. When considering testing of the mixtur e, classifiers are en couraged to use a 
tiered weight of evidence approach as in cluded in the criteria for classification 
of substances for skin corrosion an d irritation (section 3.2.1.2 and 3.2.2.2), to 
help ensure an accurate classification as  well as to avoid unnecessary animal 
testing. In the absence of any other information, a mixture is considered corrosive to skin (Skin Corrosion  Category 1) if it has a pH ≤2 or a pH ≥ 11,5. 
However, if consideration of acid/alka line reserve suggests the mixture may  
25 
 not be corrosive despite the low or high pH value, this need s to be confirmed 
by other data, preferably by data from an  appropriate validated in vitro test. 
3.2.3.2. Classification of mixtures when data are not available for the complete 
mixture: bridging principles 
3.2.3.2.1. Where the mixture itself has not b een tested to determine its skin 
corrosion/irritation potential, but there are sufficient data on the individual 
ingredients and similar tested mixtures to adequately characterise the hazards 
of the mixture, these data shall be us ed in accordance with the bridging rules 
set out in section 1.1.3. 
3.2.3.3. Classification of mixtures when data are available for all in gredients or only 
for some ingredients of the mixture 
3.2.3.3.1. In order to make use of all available da ta for purposes of classifying the skin 
corrosion/irritation hazard s of mixtures, the following assumption has been 
made and is applied where approp riate in the tiered approach: 
The "relevant ingredients" of a mixt ure are those which are present in 
concentrations ≥ 1 % (w/w for solids, liquids, dusts, mists and vapours and v/v 
for gases), unless there is a presump tion (e.g., in the case of corrosive 
ingredients) that an ingredient presen t at a concentration < 1 % can still be 
relevant for classifying the mixt ure for skin co rrosion/irritation. 
3.2.3.3.2. In general, the approach to classification of mixtures as corrosive or irritant to 
skin when data are available on the i ngredients, but not on the mixture as a 
whole, is based on the theory of additiv ity, such that each skin corrosive or 
irritant ingredient contributes to the ove rall corrosive or irri tant properties of 
the mixture in proportion to its potency  and concentration. A weighting factor 
of 10 is used for corrosive ingredients when they are present at a concentration below the generic concentration limit for classification with Category 1, but are 
at a concentration that will contribute to the classification of the mixture as irritant. The mixture is classified as corro sive or irritant to skin when the sum 
of the concentrations of such ingr edients exceeds a concentration limit.  
26 
 3.2.3.3.3. Table 3.2.3 provides the generic concentration limits to be used to determine if 
the mixture is considered to be co rrosive or irritant to the skin. 
3.2.3.3.4.1. Particular care must be taken when classifying certain types of mixtures 
containing substances such as acids a nd bases, inorganic salts, aldehydes, 
phenols, and surfactants. The approach explained in sections 3.2.3.3.1 and 3.2.3.3.2 may not be applicable given that many such substances are corrosive 
or irritant at concentrations < 1 %. 
3.2.3.3.4.2. For mixtures containing strong acids or bases the pH shall be used as a 
classification criterion (see section 3.2.3.1.2)  since pH is a better indicator of 
corrosion than the concentration limits in Table 3.2.3. 
3.2.3.3.4.3. A mixture containing ingredie nts that are corrosive or irritant to the skin and 
that cannot be classified on the basis of the additivity approach (Table 3.2.3), 
due to chemical characteristics that ma ke this approach unworkable, shall be 
classified in Skin Corrosion  Category 1 if it contains ≥ 1 % of an ingredient 
classified as Skin Corrosion or as Skin Irritation (Category 2) when it contains 
≥ 3 % of an irritant ingred ient. Classification of mixt ures with ingredients for 
which the approach in Table 3.2.3 does not apply is summarised in Table 3.2.4. 
3.2.3.3.5. On occasion, reliable data may show that  the skin corrosion/irritation hazard of 
an ingredient will not be evident when pr esent at a level at or above the generic 
concentration limits mentioned in Ta bles 3.2.3 and 3.2.4 in section 3.2.2.3.6. In 
these cases the mixture shall be classifi ed according to that  data (see also 
Articles 10 and 11). On other occasions, when it is expected that the skin 
corrosion/irritation hazard of an ingredie nt is not evident when present at a 
level at or above the generic concentrat ion limits mentioned in Tables 3.2.3 and 
3.2.4, testing of the mixture shall be c onsidered. In those cases the tiered 
weight of evidence approach shall be applied, as described in section 3.2.2.2. 
3.2.3.3.6. If there are data showing that (an) ingr edient(s) is/are corrosive or irritant to 
skin at a concentration of < 1 % (corrosive) or < 3 % (irritant), the mixture 
shall be classified accordingly.  
27 
 Table 3.2.3 
Generic concentration limits of ingredients of a mixture 
classified as Skin Corrosion  (Category 1)/Skin Irritation  (Category 2) that trigger 
classification of the mixture as corrosive/i rritant to skin where the additivity approach 
applies 
Sum of ingredients 
classified for: Concentration triggering clas sification of a mixture for: 
 Skin Corrosion Category 
1 (see note below) Skin Irritation Category 2 
Skin Corrosion Sub-
Category 1A, 1B, 1C or Category 1 ≥ 5 % ≥ 1 % but < 5 % 
Skin irritation Category 2  ≥ 10 % 
(10 x Skin Corrosion Sub-
Category 1A, 1B, 1C or Category 1) + Skin Irritation Category 2  ≥ 10 % 
Note:  
The sum of all ingredients of a mi xture classified for Skin Corrosion  Sub-
Category 1A, 1B, or 1C re spectively, shall each be ≥ 5 % respectively in order to 
classify the mixture as either Skin Corrosion Sub-Category 1A, 1B or 1C. If the sum 
of the ingredients classified as Skin Corrosion Sub-Category 1A is < 5 % but the sum 
of ingredients classified as Sk in Corrosion Sub-Category 1A+1B is ≥ 5 %, the 
mixture shall be classified as Skin Corro sion Sub-Category 1B. Similarly, if the sum 
of ingredients classified as Skin Corr osion Sub-Category 1A+1B ingredients is < 5 % 
but the sum of ingredients classifi ed as Sub-Category 1A+1B+1C is ≥ 5 % the 
mixture shall be classified as Skin Corro sion Sub-Category 1C. Where at least one 
relevant ingredient in a mixture is classified as Category 1 without sub-
categorisation, the mixture shall be classified as  Category 1 without sub-
categorisation if the sum of all ingredients corrosive to skin is ≥ 5 %.  
28 
 Table 3.2.4 
Generic concentration limits of ingredients of a mixture classified as  corrosive/irritant to 
skin that trigger classificati on of the mixture as corrosive /irritant to skin, where the 
additivity approach does not apply 
Ingredient: Concentration:  Mixture classified as: 
 
Acid with pH ≤ 2 ≥ 1 % Skin Corrosion Category 1 
Base with pH ≥ 11,5 ≥ 1 % Skin Corrosion Category 1 
Other corrosive (Sub-
Categories 1A, 1B, 1C or Category 1) ingredients  ≥ 1 % Skin Corrosion Category 1 
Other irritant (Category 2) 
ingredients, including acids 
and bases ≥ 3 % Skin Irritation Category 2 
3.2.4. Hazard Communication 
3.2.4.1. Label elements shall be used for substan ces or mixtures meeting the criteria for 
classification in this hazard cl ass in accordance with Table 3.2.5.  
29 
 Table 3.2.5 
Label elements for skin corrosion/irritation 
Classification Sub-Categories 1 A/ 1 B/1 C and Category 1 Category 2 
GHS Pictograms 
  
Signal Word Danger Warning 
Hazard Statement H314: Causes severe skin burns and eye 
damage H315: Causes 
skin 
irritation 
Precautionary Statement Prevention P260 
P264 P280 P264 
P280 
Precautionary Statement Response P301 + P330 + P331 
P303 + P361 + P353 
P363 
P304 + P340 
P310 P321 
P305 + P351 + P338 P302 + P352 
P321 
P332 + P313 P362 + P364 
Precautionary Statement Storage P405  
Precautionary Statement 
Disposal P501  
' 
(5) Chapter 3.3 is replaced by the following: 
'3.3. Serious eye damage/eye irritation 
3.3.1. Definitions and general considerations 
3.3.1.1. Serious eye damage means the production of  tissue damage in the eye, or serious 
physical decay of vision, following applicat ion of a test substance to the anterior 
surface of the eye, which is not fully re versible within 21 days of application. 
Eye irritation means the produc tion of changes in the eye following the application of 
test substance to the anterior surface of the eye, which are fully reversible within 21 days of application. 
3.3.1.2  In a tiered approach, emphasis shall be  placed upon existing human data, followed by 
existing animal data, followed by in vitro data , and then other sources of information. 
Classification results directly when the data satisfy the criteria. In other cases,  
30 
 classification of a substance or a mixture is made on the basis of the weight of 
evidence within a tier. In a total weight of  evidence approach all available information 
bearing on the determination of serious ey e damage/eye irritation is considered 
together, including the results of  appropriate validated in vitro tests, relevant animal 
data, and human data such as epidemio logical and clinical  studies and well-
documented case reports and observations (see Annex I, Part 1, section 1.1.1.3). 
3.3.2. Classification criteria for substances 
Substances are allocated to one of the cate gories within this hazard class, Category 1 
(serious eye damage) or Category 2 (eye irritation), as follows: 
 (a) Category 1 (serious eye damage):  
substances that have the potential to seriously damage the eyes (see Table 
3.3.1). 
 (b) Category 2 (eye irritation):  
substances that have the potential to i nduce reversible eye irritation (see Table 
3.3.2). 
3.3.2.1  Classification based on standard animal test data  
3.3.2.1.1   Serious eye damage (Category 1)  
3.3.2.1.1.1 A single hazard category (Category 1)  is adopted for substances that have the 
potential to seriously damage the eyes. Th is hazard category includes as criteria 
the observations listed in Table 3.3.1. Thes e observations include animals with 
grade 4 cornea lesions and other severe reactions (e.g. destru ction of cornea) 
observed at any time during the test, as well as persistent corneal opacity, 
discoloration of the cornea by a dye substance, adhesion, pannus, and interference with the function of the iris or other effects that impair sight.  In 
this context, persistent lesions are considered those which are not fully reversible within an observation period of normally 21 days. Hazard 
classification as Category 1 also contai ns substances fulfill ing the criteria of 
corneal opacity ≥ 3 or iritis > 1.5 observed in at  least 2 of 3 tested animals, 
because severe lesions like these usually do not reverse within a 21 days 
observation period.   
31 
 3.3.2.1.1.2 The use of human data is discu ssed in section 3.3.2 .2 and also in 
sections 1.1.1.3, 1.1.1.4 and 1.1.1.5. 
Table 3.3.1: Serious eye damage a 
 Criteria 
A substance that produces: 
(a) in at least one animal effects on th e cornea, iris or conjunctiva that are 
not expected to reverse or have  not fully reversed within an 
observation period of normally 21 days; and/or 
(b) in at least 2 of 3 tested animals, a positive response of: 
(i) corneal opacity ≥ 3; and/or 
(ii) iritis > 1.5; Category 1 
calculated as the mean scores fo llowing grading at 24, 48 and 72 hours 
after instillation of the test material. 
a Grading criteria are understood as described in  Regulation (EC) No 440/2008 
 
3.3.2.1.2  Eye irritation (Category 2)   
3.3.2.1.2.1 Substances that have the potential to induce reversible eye irritation shall be 
classified in Category 2 (irritating to eyes). 
3.3.2.1.2.2. For those substances where there is pronounced variability among animal 
responses, this information shall be taken into account in determining the classification. 
3.3.2.1.2..3  The use of human data is addre ssed in sections 3.3.2.2, and also in 
sections 1.1.1.3, 1.1.1.4 and 1.1.1.5.  
32 
 Table 3.3.2: Eye irritation a 
 Criteria 
Substances that produce in at least  2 of 3 tested animals a positive response 
of: 
(a) corneal opacity ≥ 1; and/or 
(b) iritis ≥ 1; and/or 
(c) conjunctival redness ≥ 2; and/or 
(d) conjunctival oedema (chemosis) ≥ 2 Category 2 
 calculated as the mean scores following grading at 24, 48 and 72 hours 
after instillation of the test material, and  which fully reverses within an  
observation period of normally 21 days. 
a  Grading criteria are understood as described in  Regulation (EC) No 440/2008 
3.3.2.2  Classification in a tiered approach 
3.3.2.2.1 A tiered approach to the evaluation of initial information shall be considered 
where applicable, recognizing that not all elements may be relevant. 
3.3.2.2.2 Existing human and animal data shall be the first line of evaluation as they give 
information directly relevant to effect s on the eye. Possible skin corrosion has 
to be evaluated prior to c onsideration of any testing for serious eye damage/eye 
irritation in order to avoid testing for lo cal effects on eyes with skin corrosive 
substances.  Skin corrosive substances sh all be considered as leading to serious 
eye damage (Category 1) as well, while  skin irritant substances may be 
considered as leading to ey e irritation (Category 2). 
3.3.2.2.3 In vitro alternatives that have been  validated and accepted shall be used to 
make classification decisions. 
3.3.2.2.4 Likewise, pH extremes like ≤ 2 and ≥ 11,5, may indicate serious eye damage, 
especially when associated with si gnificant acid/alkaline reserve (buffering 
capacity). Generally such substances ar e expected to produce significant effects 
on the eyes. In the absence of any other information, a substance is considered 
to cause serious eye damage (Category 1) if it has a pH ≤ 2 or ≥ 11,5. 
However, if consideration of acid/alka line reserve suggests the substance may 
not cause serious eye damage despite the low or high pH value, this needs to be 
confirmed by other data, pref erably by data from an appropriate validated in 
vitro test.  
33 
 3.3.2.2.5 In some cases sufficient information may be available from structurally related 
substances to make cl assification decisions.  
3.3.2.2.6 The tiered approach provides guidance on how to organize existing information 
and to make a weight-of-evidence deci sion about hazard assessment and hazard 
classification. Animal testing with co rrosive substances shall be avoided 
whenever possible. Although information might be gained from the evaluation of single parameters within a tier (see  3.3.2.1.1) consideration shall be given to 
the totality of existing information and making an overall weight of evidence 
determination.  This is especially true when there is conflict in information 
available on some parameters. 
3.3.3. Classification criteria for mixtures 
3.3.3.1. Classification of mixtures when data ar e available for the complete mixture 
3.3.3.1.1. The mixture shall be classified using th e criteria for substances, and taking into 
account the tiered approach to eval uate data for this hazard class. 
3.3.3.1.2. When considering testing of the mixtur e classifiers are encouraged to use a 
tiered weight of evidence approach as in cluded in the criteria for classification 
of substances for skin corrosion and se rious eye damage a nd eye irritation to 
help ensure an accurate classification, as  well as to avoid unnecessary animal 
testing. In the absence of any other in formation, a mixture is considered to 
cause serious eye damage (Category 1) if it has a pH ≤ 2 or ≥ 11,5. However, if 
consideration of acid/alka li reserve suggests the mixt ure may not cause serious 
eye damage despite the low or high pH value, this needs to be confirmed by 
other data, preferably data from an appropriate validated in vitro test.  
3.3.3.2. Classification of mixtures when dat a are not available for the complete 
mixture: bridging principles 
3.3.3.2.1. Where the mixture itself has not been test ed to determine its skin corrosivity or 
potential to cause serious eye damage or  eye irritation, but there are sufficient 
data on the individual ingr edients and similar tested mixtures to adequately 
characterise the hazards of the mixture, these data shall be used in accordance 
with the bridging rules set out in section 1.1.3.  
34 
 3.3.3.3. Classification of mixtures when data are available for all ingredients or only 
for some ingredients of the mixture 
3.3.3.3.1. In order to make use of a ll available data for purposes  of classifying the serious 
eye damage/ eye irritation properties of the mixtures, the following assumption 
has been made and is applied where appropriate in the tiered approach: 
 The "relevant ingredients" of a mi xture are those which are present in 
concentrations ≥ 1 % (w/w for solids, liquids, dusts, mists and vapours and v/v 
for gases), unless there is a presum ption (e.g. in the case of corrosive 
ingredients) that an ingredient presen t at a concentration < 1 % can still be 
relevant for classifying the mixture for serious eye damage/eye irritation. 
3.3.3.3.2. In general, the approach to classifica tion of mixtures as seriously damaging to 
the eye or eye irritant when data are available on the ingredients, but not on the 
mixture as a whole, is based on the theory of additivity, such that each 
corrosive or serious eye damaging/ eye ir ritant ingredient contributes to the 
overall serious eye damage/eye irr itation properties of the mixture in 
proportion to its potency and concentrati on. A weighting factor of 10 is used 
for corrosive and serious eye damaging ingredients when they are present at a concentration below the generic concentration limit for classification with Category 1, but are at a concentration that  will contribute to the classification 
of the mixture as eye irritant. The mixtur e is classified as seriously damaging to 
the eye or eye irritant when the sum of the concentrations of such ingredients 
exceeds a concentration limit. 
3.3.3.3.3. Table 3.3.3 provides the generic concentration limits to be used to determine if 
the mixture shall be classified as seriously damaging to the eye or as eye irritant. 
3.3.3.3.4.1. Particular care must be taken when classifying certain types of mixtures 
containing substances such as acids a nd bases, inorganic salts, aldehydes, 
phenols, and surfactants. The approach explained in sections 3.3.3.3.1 and 3.3.3.3.2 might not work given that many of  such substances are seriously 
damaging to the eye/eye irritant  at concentrations < 1 %.  
35 
 3.3.3.3.4.2. For mixtures containing strong acids or bases the pH shall be used as 
classification criterion (see section 3.3.3.1.2) since pH will be a better indicator 
of serious eye damage (subject to consid eration of acid/alkali reserve) than the 
generic concentration limits in Table 3.3.3. 
3.3.3.3.4.3. A mixture containing corrosive or  serious eye damaging/eye irritating 
ingredients that cannot be classifi ed based on the additivity approach 
(Table 3.3.3), due to chemical charac teristics that make this approach 
unworkable, shall be classified as Se rious Eye Damage (Category 1) if it 
contains ≥ 1 % of a skin corrosive or seri ous eye damaging i ngredients and as 
Eye Irritation (Category 2) when it contains ≥ 3 % of an eye irritant ingredient. 
Classification of mixtures  with ingredients for which the approach in 
Table 3.3.3 does not apply is summarised in Table 3.3.4. 
3.3.3.3.5. On occasion, reliable data may show that the effects of serious eye damage/eye 
irritation of an ingredient will not be evident when present at a level at or 
above the generic concentration limits  mentioned in Tables 3.3.3 and 3.3.4 in 
section 3.3.3.3.6.  In these ca ses the mixture shall be classified according to 
those data. On other occasions, when  it is expected that the skin 
corrosion/irritation hazards or the effects of serious eye damage/irritation of an 
ingredient will not be evident when pres ent at a level at or above the generic 
concentration limits mentioned in Tabl es 3.3.3 and 3.3.4, testing of the mixture 
shall be considered. In those cases, the tiered weight of evidence approach shall 
be applied. 
3.3.3.3.6. If there are data showing th at (an) ingredient(s) may be  corrosive to the skin or 
seriously damaging to the eye/eye irritating at a concentration of < 1 % 
(corrosive to the skin or seri ously damaging to the eye) or < 3 % (eye irritant), 
the mixture shall be classified accordingly.  
36 
 Table 3.3.3 
Generic concentration limits of ingredients of  a mixture classified  as Skin Corrosion 
Category 1 and/or Serious Eye Damage or Eye I rritation that trigger classification of the 
mixture as Serious Eye Damage or Eye Irrita tion (Category 1 or 2), where the additivity 
approach applies 
Concentration triggering classification 
of a mixture as: 
Serious Eye Damage Eye irritation Sum of ingredients classified as: 
Category 1 Category 2 
Skin Corrosion Sub-Category 1A, 1B, 
1C or Category 1 + Serious Eye Damage ( Category 1)
a ≥ 3 % ≥ 1 % but < 3 % 
Eye Irritation ( Category 2)  ≥ 10 % 
10 x (Skin Corrosion Sub-Category 1A, 
1B, 1C or Skin Corrosion Category 1 + Serious Eye Damage ( Category 1) + Eye Irritation (Category 2)  ≥ 10 % 
  
a If an ingredient is classified as both Skin Corrosion Sub-Category 1A, 1B, 1C or Category 1 and  Serious Eye 
Damage (Category 1), its concentration is considered only once in the calculation. 
  
37 
 Table 3.3.4 
Generic concentration limits of ingredients of a that trigger classifi cation of the mixture 
as causing serious eye damage (Category 1)/eye irritation (Category 2), where the 
additivity approach does not apply 
Ingredient Concentration Mixture classified as: 
 
Acid with pH ≤ 2 ≥ 1 % Category 1 
Base with pH ≥ 11,5 ≥ 1 % Category 1 
Other ingredient classified as causing 
serious eye damage (Category 1)  ≥ 1 % Category 1 
Other ingredient classified as Eye 
Irritation (Category 2)   ≥ 3 % Category 2 
 
3.3.4. Hazard Communication 
3.3.4.1. Label elements shall be used for substan ces or mixtures meeting the criteria for 
classification in this hazard cl ass in accordance with Table 3.3.5.  
38 
 Table 3.3.5 
Label elements for serious eye damage/eye irritation a 
Classification Category 1 Category 2 
GHS Pictograms 
  
Signal Word Danger Warning 
Hazard Statement H318: Causes serious 
eye damage H319: Causes serious eye 
irritation 
Precautionary Statement Prevention P280 P264 
P280 
Precautionary Statement Response P305 + P351 + P338 
P310 P305 + P351 + P338 
P337 + P313 
Precautionary Statement Storage   
Precautionary Statement 
Disposal   
a Where a chemical is classified as Skin  Corrosion Sub-Category 1A, 1B, 1C or Categor y 1, labelling for serious eye damage/eye irritation 
can be omitted as this information is already included in  the hazard statement for Skin  Corrosion Category 1 (H314).' 
 
(6) In section 3.5.2.3.5, the second indent is deleted.  
39 
 D. Part 4 is amended as follows: 
(1) Section 4.1.1.1 is amended as follows: 
(a) Point (b) is deleted. 
(b) In point (j), the term 'long-term hazard' is replaced by the term 'long-term (chronic) 
hazard'. 
(c) The following point is added :  
'short term (acute) hazard' means for classi fication purposes the hazard of a substance 
or mixture caused by its acute  toxicity to an organism  during short-term aquatic 
exposure to that substance or mixture.' 
(2) Section 4.1.1.2.0 is replaced by the following: 
'Hazardous to the aquatic environment is differentiated into: - short-term (acute) aquatic hazard 
- long-term (chronic) aquatic hazard.' 
(3) In section 4.1.1.3.1, the third sentence  is replaced by the following:  
'The basis, therefore, of the identification of short- term (acute) and long-term 
(chronic) hazards is the aquati c toxicity of the substance or  mixture, although this shall 
be modified by taking account of furthe r information on the degradation and 
bioaccumulation behaviour, if appropriate.' 
(4) In section 4.1.2.1,  the first and second se ntence are replaced by the following:  
'The system for classification r ecognises that the intrinsic ha zard to aquatic organisms is 
represented by both the acute and chronic toxicity of a substan ce. For the long-term (chronic) 
hazard, separate hazard categories are defined re presenting a gradation in  the level of hazard 
identified.' 
(5) Section 4.1.2.2 is replaced by the following: 
'The core classification system for substances  consists of one shor t-term (acute) hazard 
classification category and three long-term (c hronic) hazard classification categories. The 
short-term (acute) and long-term (chroni c) classification ca tegories are applied 
independently.' 
(6) Section 4.1.2.3 is replaced by the following: 
'The criteria for classification of a substance in Acute 1 are defined on the basis of acute 
aquatic toxicity data only (EC50 or LC 50). The criteria for classification of a substance into 
Chronic 1 to 3 follow a tiered approach where the first step is to see if  available information  
40 
 on chronic toxicity merits long- term (chronic) hazard classifica tion. In absence of adequate 
chronic toxicity data, the subse quent step is to combine two t ypes of information, i.e. acute 
aquatic toxicity data and environmental fate data (degradability and bioaccumulation data) 
(see figure 4.1.1).' 
(7) The title of Figure 4.1.1 is replaced by: 
'Categories for substances long-term (chroni c) hazardous to the aquatic environment' 
(8) Section 4.1.2.4. is replaced by the following: 
'The system also introduces a ‘safety net’ clas sification (referred to as Chronic 4) for use 
when the data available do  not allow classi fication under the formal criteria for Acute 1 or 
Chronic 1 to 3 but there are nevertheless some grounds for concern (see example Table 
4.1.0).' 
(9) Table 4.1.0 is replaced by the following: 
'Table 4.1.0 
Classification categories for haza rdous to the aquatic environment  
(a) Short-term (acute) aquatic hazard 
Category  Acute 1 : (Note 1) 
96 hr LC 50 (for fish) ≤1 mg/l and/or 
48 hr EC 50 (for crustacea) ≤1 mg/l and/or 
72 or 96 hr ErC 50 (for algae or other aquatic plants) ≤1 mg/l. (Note 2) 
(b) Long-term (chronic) aquatic hazard 
(i) Non-rapidly degradable substa nces (Note 3) for which there are adequate chronic toxicity 
data available  
Category Chronic 1:  (Note 1) 
Chronic NOEC or EC x (for fish) ≤0,1 mg/l and/or 
Chronic NOEC or EC x (for crustacea) ≤0,1 mg/l and/or 
Chronic NOEC or EC x (for algae or other aquatic plants) ≤0,1 mg/l.  
Category Chronic 2:    
Chronic NOEC or EC x (for fish) ≤1 mg/l and/or  
41 
 Chronic NOEC or EC x (for crustacea) ≤1 mg/l and/or 
Chronic NOEC or EC x (for algae or other aquatic plants) ≤1 mg/l. 
(ii) Rapidly degradable substan ces (Note 3) for which there are adequate chronic toxicity data 
available  
Category Chronic 1:   (Note 1) 
Chronic NOEC or EC x (for fish) ≤0,01 mg/l and/or 
Chronic NOEC or EC x (for crustacea) ≤0,01 mg/l and/or 
Chronic NOEC or EC x (for algae or other aquatic plants) ≤0,01 mg/l.  
Category Chronic 2:    
Chronic NOEC or EC x (for fish) ≤0,1 mg/l and/or 
Chronic NOEC or EC x (for crustacea) ≤0,1 mg/l and/or 
Chronic NOEC or EC x (for algae or other aquatic plants) ≤0,1 mg/l. 
Category Chronic 3:    
Chronic NOEC or EC x (for fish) ≤1 mg/l and/or 
Chronic NOEC or EC x (for crustacea) ≤1 mg/l and/or 
Chronic NOEC or EC x (for algae or other aquatic plants) ≤1 mg/l. 
(iii) Substances for which adequate ch ronic toxicity data are not available 
Category Chronic 1:   (Note 1) 
96 hr LC 50 (for fish) ≤1 mg/l and/or 
48 hr EC 50 (for crustacea) ≤1 mg/l and/or 
72 or 96 hr ErC 50 (for algae or other aquatic plants) ≤1 mg/l. (Note 2) 
and the substance is not rapidly degradable and/or the experimentally determined BCF ≥ 500 
(or, if absent, the log K ow ≥ 4). (Note 3). 
Category Chronic 2:    
96 hr LC 50 (for fish) >1 to ≤10 mg/l and/or  
42 
 48 hr EC 50 (for crustacea) >1 to ≤10 mg/l and/or 
72 or 96 hr ErC 50 (for algae or other aquatic plants) >1 to ≤10 mg/l (Note 2) 
and the substance is not rapidly degradable and/or the experimentally determined BCF ≥ 500 
(or, if absent, the log K ow ≥ 4). (Note 3). 
Category Chronic 3:    
96 hr LC 50 (for fish) > 10 to ≤ 100 mg/l and/or 
48 hr EC 50 (for crustacea) > 10 to ≤ 100 mg/l and/or 
72 or 96 hr ErC 50 (for algae or other aquatic plants) > 10 to ≤ 100 mg/l. (Note 2) 
and the substance is not rapidly degradable and/or the experimentally determined BCF ≥ 500 
(or, if absent, the log K ow ≥ 4). (Note 3). 
"Safety net" classification 
Category Chronic 4  
Cases when data do not allow classification under the above criteria but there are nevertheless 
some grounds for concern. This includes, for ex ample, poorly soluble substances for which no 
acute toxicity is recorded at levels up to the water solubility (note 4), and which are not 
rapidly degradable in accordance with se ction 4.1.2.9.5 and have an experimentally 
determined BCF ≥ 500 (or, if absent, a log Kow ≥ 4), indicating a potential to bioaccumulate, 
which will be classified in this category unl ess other scientific evidence exists showing 
classification to be unnecessary. Such eviden ce includes chronic toxi city NOECs > water 
solubility or > 1 mg/l, or othe r evidence of rapid degradation in  the environment than the ones 
provided by any of the methods  listed in section 4.1.2.9.5. 
'  
43 
 (10) In section 4.1.3.2, Figure 4.1.2 is replaced by the following: 
'Figure 4.1.2 
Tiered approach to classification of mixtures 
for short-term (acute) and long-term (c hronic) aquatic environmental hazards 
' 
(11) In section 4.1.3.3.2, the first sentence  is replaced by the following:,  
'The long-term (chronic) hazard classificat ion of mixtures requires additional 
information on degradability and in certain cases bioaccumulation.'  
(12) In section 4.1.3.3.3, the last sentence is replaced by the following: 
'No need to classify for short-term (acute) hazard.' 
(13) In section 4.1.3.3.4, the last sentence is replaced by the following: 
'No need to classify for long-term (chronic)  hazard in categorie s Chronic 1, 2 or 3.' 
(14) In section 4.1.3.5.2, point (a), the last sent ence is replaced by the following:   Aquatic toxicity test data available on the mixture as a whole
Sufficient data available on 
similar mixtures to estimate 
hazards  Yes No 
Yes 
Apply bridging principles
(see 4.1.3.4.)  CLASSIFY  
for short-term(acute)/long-term 
(chronic)aquatic hazard  
(see 4.1.3.3)  
CLASSIFY  
for short-term (acute)/long-term 
(chronic) aquatic hazard  No 
Either aquatic toxicity or 
classification data available for all 
relevant components  Yes 
Apply summation method (see 
4.1.3.5.5) using: 
• Percentage of all 
components classified as "Chronic" 
• Percentage of components 
classified as "Acute" 
• Percentage of components 
with acute or chronic toxicity data: apply additivity formulas (see 4.1.3.5.2) and convert the derived L(E)C
50 
or EqNOECm to the appropriate "Acute" or 
"Chronic" category CLASSIFY  
for short-term (acute)/long-term  chronic hazard
 
Use available hazard data 
of known components  No 
Apply summation method and/or 
additivity formula (see 4.1.3.5) and apply 4.1.3.6CLASSIFY  
for short-term (acute)/long-term 
(chronic) hazard   
44 
 'The calculated toxicity may be used to a ssign that portion of the mixture a short-term 
(acute) hazard category which is then subs equently used in applying the summation 
method;' 
(15) In section 4.1.3.5.2, point (b), the last se ntence is replaced by the following: 
'The calculated equivalent toxicity may be us ed to assign that portion of the mixture a 
long-term (chronic) hazard category, in accordance with the criteria for rapidly 
degradable substances (point (b)(ii) of Table 4.1.0), which is then subsequently used in 
applying the summation method.' 
(16) Section 4.1.3.5.5.3.2 is replaced by the following:  
'The classification of mixtures for short- term (acute) hazards based on this summation 
of classified components is  summarised in Table 4.1.1.' 
(17) In section 4.1.3.5.5.3.2 the title of Table 4.1.1 is replaced by the following:  
'Classification of a mixture for short-term  (acute) hazards based on summation of 
classified components' 
(18) Section 4.1.3.5.5.4.5 is replaced by the following:  
'The classification of mixtures for lo ng-term (chronic) hazards, based on this 
summation of the concentrations of classi fied components, is summarised in Table 
4.1.2.' 
(19) The title of Table 4.1.2 is replaced by the following: 
'Classification of a mixture for long-term (chronic) hazards, based on summation of 
the concentration of classified components' 
(20) In section 4.1.3.6.1, the first sentence  is replaced by the following:  
'In the event that no useable information on short term (acute) and/or long-term 
(chronic) aquatic hazard is available for one or more relevant components, it is 
concluded that the mixture cannot be attr ibuted to one or more definitive hazard 
category(ies).' 
(21) In section 4.1.4, Table 4.1.4 is replaced by the following:  
'Table 4.1.4 
Label elements for hazardous to the aquatic environment 
SHORT-TERM (ACUTE) AQUATIC 
HAZARD 
 Acute1  
45 
 GHS Pictogram 
 
Signal Word Warning 
Hazard Statement H400: Very toxic to 
aquatic life 
Precautionary 
Statement 
Prevention P273 
Precautionary 
Statement Response P391 
Precautionary 
Statement Storage  
Precautionary 
Statement Disposal P501  
46 
  
LONG-TERM (CHRONIC) AQUATIC HAZARD 
 Chronic 1 Chronic 2 Chronic 3 Chronic 4 
GHS Pictograms 
 
  No pictogram is 
used No pictogram is 
used 
Signal Word Warning No signal word 
is used No signal word is 
used No signal word is 
used 
Hazard Statement H410: Very toxic 
to aquatic life 
with long lasting 
effects H411: Toxic to 
aquatic life with 
long lasting 
effects H412: Harmful to 
aquatic life with 
long lasting 
effects H413: May cause 
long lasting 
harmful effects to 
aquatic life 
Precautionary  
Statement  
Prevention P273 P273 P273 P273 
Precautionary 
Statement 
Response P391 P391   
Precautionary 
Statement Storage     
Precautionary 
Statement Disposal P501 P501 P501 P501 
'  
47 
 ANNEX II  
In Annex II to Regulation (EC)  No 1272/2008, in Part 2, Section 2.8 a new last paragraph is 
added: 
'Where a mixture is labelled in accordance w ith section 2.4 or 2.5, the statement EUH208 may 
be omitted from the label for the substance concerned.'  
48 
 ANNEX III 
Annex III to Regulation (EC) No 1272/2008, Part  1, Table 1.2 is amended as follows: 
(1) The entry concerning code H314 is replaced by the following:  ' 
H314 Language 3.2 – Skin corrosion/irritation, Hazard Category 1, Sub-
Categories 1A, 1B, 1C 
 BG Причинява  тежки  изгаряния  на кожата  и сериозно  увреждане  
на очите . 
 ES Provoca quemaduras graves en la  piel y lesiones oculares graves. 
 CS Zp ůsobuje těžké poleptání k ůže a poškození o čí. 
 DA Forårsager svære forbrændinger af huden og øjenskader. 
 DE Verursacht schwere Verä tzungen der Haut und schwere 
Augenschäden. 
 ET Põhjustab rasket nahasöövitust ja silmakahjustusi. 
 EL Προκαλεί  σοβαρά  δερματικά  εγκαύματα  και οφθαλμικές  βλάβες . 
 EN Causes severe skin burns and eye damage. 
 FR Provoque des brûlures de la peau  et de graves lésions des yeux. 
 GA Ina chúis le dónna tromchúiseach a craicinn agus le damáiste don 
tsúil. 
 HR Uzrokuje teške opekline kože i ozljede oka. 
 IT Provoca gravi ustioni cutanee e gravi lesioni oculari. 
 LV Izraisa smagus ādas apdegumus un acu boj ājumus. 
 LT Smarkiai nudegina od ą ir pažeidžia akis. 
 HU Súlyos égési sérülést és szemkárosodást okoz.  
49 
 H314 Language 3.2 – Skin corrosion/irritation, Hazard Category 1, Sub-
Categories 1A, 1B, 1C 
 MT Jag ħmel ħruq serju lill- ġilda u ħsara lill-g ħajnejn. 
 NL Veroorzaakt ernstige brandwonden en oogletsel. 
 PL Powoduje powa żne oparzenia skóry oraz uszkodzenia oczu . 
 PT Provoca queimaduras na pele e lesões oculares graves. 
 RO Provoac ă arsuri grave ale pielii şi lezarea ochilor. 
 SK Spôsobuje vážne poleptanie kože a poškodenie o čí. 
 SL Povzro ča hude opekline kože in poškodbe o či. 
 FI Voimakkaasti ihoa syövyttävää ja silmiä vaurioittavaa. 
 SV Orsakar allvarliga frätskador på hud och ögon. 
' 
(2) The entry concerning H318 is replaced by the following: ' 
H318 Language 3.3 – Serious eye damage/eye irritation, Hazard Category 1 
 BG Предизвиква  сериозно  увреждане  на очите . 
 ES Provoca lesiones oculares graves. 
 CS Zp ůsobuje vážné poškození o čí. 
 DA Forårsager alvorlig øjenskade. 
 DE Verursacht schwere Augenschäden. 
 ET Põhjustab raskeid silmakahjustusi. 
 EL Προκαλεί  σοβαρή  οφθαλμική  βλάβη . 
 EN Causes serious eye damage.  
50 
 H318 Language 3.3 – Serious eye damage/eye irritation, Hazard Category 1 
 FR Provoque de graves lésions des yeux. 
 GA Ina chúis le damáiste tromchúiseach don tsúil. 
 HR Uzrokuje teške ozljede oka. 
 IT Provoca gravi lesioni oculari. 
 LV Izraisa nopietnus acu boj ājumus. 
 LT Smarkiai pažeidžia akis. 
 HU Súlyos szemkárosodást okoz. 
 MT Jag ħmel ħsara serja lill-g ħajnejn. 
 NL Veroorzaakt ernstig oogletsel. 
 PL Powoduje powa żne uszkodzenie oczu. 
 PT Provoca lesões oculares graves. 
 RO Provoac ă leziuni oculare grave. 
 SK Spôsobuje vážne poškodenie o čí. 
 SL Povzro ča hude poškodbe o či. 
 FI Vaurioittaa vakavasti silmiä. 
 SV Orsakar allvarliga ögonskador. 
'  
51 
 ANNEX IV  
Annex IV to Regulation (EC) No 1272/2008 is amended as follows: 
(1) The introductory statement is amended as follows: 
(a) The third paragraph is replaced by the following:  
'When a forward slash or diagonal mark [/] appears in a precautionary statement text 
in column (2), this indicates that the text in square brackets is not  appropriate in every 
case and should be used only in certain ci rcumstances. In these cases, conditions for 
use explaining when the text should be used are given in column (5).' 
(b) The following paragraph is inserted  after the fourth paragraph: 
'Where the text in column 5 indicates that a precautionary statement may be omitted if 
another precautionary statement is given on th e label, this information may be used in 
selecting precautionary statements in  accordance with Articles 22 and 28.' 
(2) Part 1 is amended as follows: 
(a) Table 6.2 is amended as follows: 
(i) The entry concerning code P202 is replaced by the following: 
Flammable gases 
(including chemically unstable gases) (section 2.2) A, B 
(chemically 
unstable gases)  
Germ cell 
mutagenicity (section 3.5) 1A, 1B, 2  
Carcinogenicity 
(section 3.6) 1A, 1B, 2  'P202 Do not handle until all safety 
precautions have been read and understood. 
Reproductive 
toxicity (section 3.7) 1A, 1B, 2'   
52 
 (ii) The entry concerning code P220 is replaced by the following: 
Oxidising 
gases (section 2.4) 1 
Oxidising 
liquids (section 2.13) 1,2,3 'P220 Keep away from clothing 
and other combustible 
materials. 
Oxidising 
solids (section 2.14) 1,2, 3'  
 
(iii) The entry concerning code P221 is deleted. 
(iv) The entries concerning codes P222, P 223, P230, P231 are replaced by the 
following: 
Pyrophoric 
liquids (section 2.9) 1 
'P222 Do not allow contact with 
air. 
Pyrophoric 
solids (section 2.10) 1 - if emphasis of the hazard 
statement is deemed necessary  
P223 Do not allow contact with 
water. Substances and 
mixtures which, in contact with 
water, emit 
flammable gases (section 2.12) 1, 2 - if emphasis of the hazard 
statement is deemed necessary   
53 
 P230 Keep wetted with... Explosives 
(section 2.1) Divisions 
1.1, 1.2, 1.3, 1.5 - for substances and 
mixtures which are wetted, diluted, dissolved or suspended with a phlegmatiser in order to reduce or suppress their explosive properties (desensitised explosives) 
…Manufacturer/supplier to 
specify appropriate material.  
Pyrophoric 
liquids (section 2.9) 
 1 
Pyrophoric 
solids (section 2.10) 1 …Manufacturer/supplier to 
specify appropriate liquid or gas if “inert gas” is not appropriate.  P231 Handle and store contents 
under inert gas/… 
Substances and 
mixtures which, in contact with water, emit flammable gases (section 2.12) 1,2,3 - if the substance or 
mixture reacts readily with moisture in air. 
…Manufacturer/supplier to 
specify appropriate liquid or gas if “inert gas” is not appropriate.'  
 
(v) The entries concerning codes P 233, P234, P235, P240, P241, P242, P243 are 
replaced by the following: 
  
54 
 Flammable 
liquids (section 2.6) 1, 2, 3 - if the liquid is 
volatile and may generate an explosive atmosphere 
Pyrophoric liquids (section 2.9) 1  
Pyrophoric 
solids (section 2.10) 1  
Acute toxicity – 
inhalation (section 3.1)  1, 2, 3 
Specific target 
organ toxicity – single exposure; respiratory tract irritation (section 3.8) 3 'P233 Keep container tightly closed. 
Specific target 
organ toxicity – single exposure; narcotic effects (section 3.8) 3 - if the chemical is 
volatile and may generate a hazardous atmosphere 
Explosives (Section 2.1) Divisions 
1.1, 1.2, 1.3, 1.4,1.5 
Self-reactive substances and mixtures (section 2.8) Types  
A, B, C, D, E, F 
Organic peroxides (section 2.15) Types  
A, B, C, D, E, F P234 Keep only in original packaging. 
Corrosive to 
metals (section 2.16) 1   
55 
 Flammable 
liquids (section 2.6) 1, 2, 3 - for flammable liquids 
category 1 and other flammable liquids that are volatile and may generate an explosive atmosphere 
Self-reactive substances and mixtures (Section 2.8)  Types  
A, B, C, D, E, F - may be omitted if 
P411 is given on the label 
Self-heating substances and mixtures (section 2.11) 1, 2 - may be omitted if 
P413 is given on the label P235 Keep cool. 
Organic 
peroxides (section 2.15) Types  
A, B, C, D, E, F - may be omitted if 
P411 is given on the label 
Explosives (section 2.1) Divisions 
1.1, 1.2, 1.3, 1.4, 1.5 - if the explosive is 
electrostatically sensitive 
Flammable liquids (section 2.6) 1,2,3 - if the liquid is 
volatile and may generate an explosive atmosphere 
Flammable solids (section 2.7) 1,2 - if the solid is 
electrostatically sensitive 
Self-reactive substances and mixtures (section 2.8) P240 Ground and bond container and 
receiving equipment. 
Organic 
peroxides (section 2.15) Types 
A,B,C, D, E, F 
 - if electrostatically 
sensitive and able to generate an explosive atmosphere 
  
56 
 Flammable 
liquids (section 2.6) 1, 2, 3 - if the liquid is 
volatile and may generate an explosive atmosphere. 
- text in square 
brackets may be used to specify specific electrical, ventilating, lighting or other equipment if necessary and as appropriate. 
 P241 Use explosion-proof 
[electrical/ventila ting/lighting/...] 
equipment. 
Flammable 
solids (section 2.7) 1, 2 - if dust clouds can 
occur. 
- text in square 
brackets may be used to specify specific electrical, ventilating, lighting or other equipment if necessary and as appropriate. 
 
P242 Use non-sparking tools. Flammable 
liquids (section 2.6) 1, 2, 3 - if the liquid is 
volatile and may generate an explosive atmosphere and if the minimum ignition energy is very low.( This applies to substances and mixtures where the ignition energy is <0.1 mJ, e.g. carbon disulphide). 
 
P243 Take action to prevent static 
discharges. Flammable 
liquids (section 2.6) 1, 2, 3 - if the liquid is 
volatile and may generate an explosive atmosphere.' 
 
 
(vi) The entry concerning code P250 is replaced by the following:  
57 
  
'P250 Do not subject to 
grinding/shock/friction… Explosives (section 
2.1) Unstable 
explosives 
and 
divisions 
1.1, 1.2, 1.3, 1.4, 
1.5 - if the explosive is 
mechanically sensitive 
 …Manufacturer/supplier 
to specify applicable rough handling.' 
 
(vii) The entry concerning code P261 is replaced as follows: 
Acute toxicity –
inhalation (section 3.1) 3, 4 
Respiratory 
sensitisation (section 3.4) 1, 1A, 1B
Skin sensitisation 
(section 3.4) 1, 1A, 1B
Specific target organ 
toxicity – single exposure; respiratory tract irritation (section 3.8) 3 'P261 Avoid breathing 
dust/fume/gas/mist/vapou
rs/spray . 
Specific target organ 
toxicity – single exposure; narcosis (section 3.8) 3 – may be omitted if 
P260 is given on the label 
 
Manufacturer/supplier 
to specify applicable conditions.' 
 
 
(viii)  The entry concerning code P263 is   replaced by the following:  
58 
 'P263 Avoid contact during 
pregnancy and while nursing. Reproductive toxicity – 
effects on or via lactation (section 3.7) Additional 
category'   
 
(ix) The entries concerning codes P280, P282, P283, P284, P231+P232 are 
replaced by the following: 
Explosives (section 
2.1) Unstable 
explosives 
and 
divisions 
1.1, 1.2, 
1.3, 1.4, 1.5
Flammable liquids (section 2.6) 1, 2, 3 
Flammable solids 
(section 2.7) 1, 2 
Self-reactive 
substances and mixtures (section 2.8) Types A, 
B, C, D, E, 
F 
Pyrophoric liquids (section 2.9) 1 
Pyrophoric solids 
(section 2.10) 1 
Self-heating 
substances and mixtures (section 2.11) 1, 2 
Substances and 
mixtures which, in contact with water, emit flammable gases (section 2.12) 1, 2, 3 
Oxidising liquids 
(section 2.13) 1, 2, 3 
Oxidising solids 
(section 2.14) 1, 2, 3 
Organic peroxides 
(section 2.15) Types A, 
B, C, D, E, 
F Manufacturer/supplier 
to specify the appropriate type of equipment.  'P280 Wear protective 
gloves/protective clothing/eye protection/face protection.  
Acute toxicity –
dermal (section 3.1) 1, 2, 3, 4 - Specify protective 
gloves/clothing Manufacturer/supplier may further specify type of equipment where appropriate.   
59 
 Skin corrosion 
(section 3.2) 1, 1A, 1B, 
1C - Specific protective 
gloves/clothing and eye/face protection  
Manufacturer/supplier may further specify type of equipment where appropriate.  
Skin irritation (section 3.2) 2 
Skin sensitisation 
(section 3.4) 1, 1A, 1B – Specify protective 
gloves. Manufacturer/supplier may further specify type of equipment where appropriate.  
Serious eye damage (section 3.3) 1   
Eye irritation (section 
3.3) 2 – Specify eye/face 
protection.  
Manufacturer/supplier may further specify type of equipment where appropriate.  
  Germ cell 
mutagenicity (section 3.5) 1A, 1B, 2 
   Carcinogenicity 
(section 3.6) 1A, 1B, 2 
  Reproductive toxicity 
(section 3.7) 1A, 1B, 2  
 Manufacturer/ supplier to specify the appropriate type of equipment.   
60 
 P282 Wear cold insulating gloves and 
either face shield or eye protection.Gases under 
pressure (section 2.5) Refrigerated 
liquefied 
gas  
Oxidising 
liquids (section 2.13) 1  
P283 Wear fire resistant or flame 
retardant clothing. 
Oxidising solids 
(section 2.14) 1  
Acute toxicity – 
inhalation 
(section 3.1) 1, 2 P284 [In case of inadequate ventilation] 
wear respiratory protection. 
Respiratory 
sensitisation 
(section 3.4) 1, 1A, 1B – text in square 
brackets may be 
used if additional 
information is 
provided with the 
chemical at the 
point of use that 
explains what type 
of ventilation 
would be adequate 
for safe use.” 
Manufacturer/sup
plier to specify 
equipment. 
 
Pyrophoric 
liquids (Section 
2.9)  
1 
Pyrophoric 
solids (Section 2.10)  
1 …Manufacturer/s
upplier to specify 
the appropriate liquid or gas if “inert gas” is not appropriate. P231 
+ 
P232 Handle and store contents under 
inert gas/...  
 Protect from moisture.  
Substances and 
mixtures which, in contact with water, emit flammable gases (section 2.12) 1, 2, 3 - if the substance 
or mixture reacts readily with moisture in air. 
… 
Manufacturer/supplier to specify appropriate liquid or gas if “inert gas” is not appropriate.'  
61 
  
(x) The entry concerning code P235+P410 is deleted. 
 
(b) Table 6.3 is amended as follows: 
(i) The entry concerning code P302 is replaced by the following: 
 
Pyrophoric liquids (section 
2.9) 1 
Pyrophoric solids (section 
2.10) 1 
Substances and mixtures 
which, in contact with water, emit flammable gases (section 2.12) 1,2 'P302 IF ON SKIN: 
Acute Toxicity, dermal 
(section 2.1) 1,2,3,4  
  Skin irritation (section 3.2) 2  
  Skin sensitisation (section 
3.4) 1, 1A, 1B'  
 
(ii) The entry concerning code P312 is replaced by the following: 
Acute toxicity – oral 
(section 3.1)  4 
Acute toxicity – dermal 
(section 3.1)  3, 4 
Acute toxicity – inhalation 
(section 3.1)  4 
Specific target organ 
toxicity – single exposure; respiratory tract irritation (section 3.8)  3 'P312 Call a POISON 
CENTER/doctor/... if you feel unwell.  
Specific target organ 
toxicity – single exposure; narcosis (section 3.8) 3 …Manufacturer/supplier 
to specify the appropriate source of emergency medical advice.'  
 
(iii) The entries concerning codes P313, P314, P315, P320, P321 are replaced by 
the following:  
62 
 Skin irritation (section 
3.2) 2 
Eye irritation (section 
3.3) 2 
Skin sensitisation (section 
3.4) 1, 1A, 1B 
Germ cell mutagenicity 
(section 3.5) 1A, 1B, 2 
Carcinogenicity (section 
3.6) 1A, 1B, 2 
Reproductive toxicity 
(section 3.7) 1A, 1B, 2 'P313 Get medical 
advice/attention. 
Reproductive toxicity – 
effects on or via lactation (section 3.7) Additional 
category Manufacturer/supplier 
to select medical advice or attention as appropriate.  
P314 Get medical 
advice/attention if you feel unwell. Specific target organ 
toxicity – repeated exposure (section 3.9) 1, 2 Manufacturer/supplier 
to select medical advice or attention as appropriate.  
P315 Get immediate 
medical advice/attention. Gases under pressure 
(section 2.5) Refrigerated 
liquefied 
gas Manufacturer/supplier 
to select medical advice or attention as appropriate.  
P320 Specific treatment is 
urgent (see ... on this label). Acute toxicity – 
inhalation (section 3.1)  1, 2 
– if immediate 
administration of antidote is 
required. 
... Reference to 
supplemental first aid instruction. 
 
Acute toxicity – oral 
(section 3.1)  1, 2, 3 – if immediate 
administration of antidote is required. 
… Reference to 
supplemental first aid instruction. 
 P321 Specific treatment 
(see ... on this label). 
Acute toxicity, dermal 
(section 3.1) 1, 2, 3, 4 
– if immediate 
measures such as  
63 
 specific cleansing 
agent are advised.  
… Reference to 
supplemental first aid instruction. 
 
Acute toxicity –
inhalation (section 3.1)  3 – if immediate 
specific measures are required. 
... Reference to 
supplemental first aid instruction. 
 
Skin corrosion (section 
3.2) 1, 1A, 1B, 
1C 
Skin irritation (section 3.2) 2 
Skin sensitisation 
(section 3.4) 1, 1A,1B ... Reference to 
supplemental first aid instruction. 
 Manufacturer/sup-
plier may specify 
a cleansing agent 
if appropriate. 
 
Specific target organ 
toxicity – single exposure (section 3.8) 1 – if immediate 
measures are required. 
... Reference to 
supplemental first aid instruction.' 
 
 
(iv) The entry concerning code P334 is replaced by the following: 
Pyrophoric liquids (section 
2.9) 1 
Pyrophoric solids (section 
2.10) 1 -text in square 
brackets to be used for pyrophoric liquids and solids'P334 Immerse in cool water 
[or wrap in wet bandages]. 
Substances and mixtures 
which, in contact with 
water, emit flammable 
gases (section 2.12) 1, 2 Use only 
“immerse in cool 
water.” Text in 
square brackets should not be used.' 
  
64 
 (v) The entry concerning code P353 is replaced by the following: 
Flammable liquids 
(section 2.6)  1, 2, 3 'P353 Rinse skin with water 
[or shower]. 
Skin corrosion (section 
3.2) 1, 1A, 1B, 
1C -text in square 
brackets to be included where the manufacturer/supplier considers it appropriate for the specific chemical.' 
 
(vi) The entry concerning code 370 is replaced by the following: 
Explosives (section 2.1)  Unstable 
explosives 
and divisions 
1.1, 1.2, 1.3, 
1.4, 1.5 
Oxidising gases (section 2.4) 1 
Flammable liquids (section 
2.6) 1, 2, 3 
Flammable solids (section 
2.7) 1, 2 
Self-reactive substances 
and mixtures  (section 2.8)  Types A, B, 
C, D, E, F’ 
Pyrophoric liquids (section 2.9) 1 
Pyrophoric solids (section 
2.10) 1 
Substances and mixtures 
which, in contact with water, emit flammable gases (section 2.12)  1, 2, 3 
Oxidising liquids (section 
2.13) 1, 2, 3 
Oxidising solids (section 
2.14) 1, 2, 3 'P370 In case of fire: 
Organic Peroxides (section 
2.15) Types 
A,B,C, D, E, 
F'  
 
(vii) The entries concerning codes P372 and P373 are replaced by the following:  
65 
 Unstable 
explosives 
and 
Divisions 
1.1, 1.2, 1.3, 
and  1.5  Explosives (section 2.1)  
Division 1.4 – except for 
explosives of division 1.4 (compatibility group S) in transport packaging.  
Self-reactive substances 
and mixtures (section 2.8) Type A 'P372 Explosion risk. 
Organic peroxides (section 
2.15) Type A  
Unstable 
explosives 
and 
Divisions 
1.1, 1.2, 1.3, 
1.4, 1.5  Explosives (section 2.1)  
Division 1.4 – except for 
explosives of division 1.4 (compatibility group S) in transport packaging.  
Self-reactive substances 
and mixtures (section 2.8) Type A P373 DO NOT fight fire 
when fire reaches explosives. 
Organic peroxides (section 
2.15) Type A'  
 
(viii)  The entry concerning code P374 is deleted. 
(ix) The entry concerning code P375 is replaced by the following: 
Explosives (section 2.1) Division 1.4 
Self-reactive substances 
and mixtures  (section 2.8)  Type B 'P375 Fight fire remotely due 
to the risk of explosion. 
Oxidising liquids (section 
2.13) 1 - for explosives 
of division 1.4 
(compatibility group S) in transport packaging.'  
66 
 Oxidising solids (section 
2.14) 1 
Organic peroxides (section 
2.15) Type B 
 
(x) The entries concerning codes P378, P380, P381 are replaced by the following: 
Flammable liquids 
(section 2.6)  1, 2, 3 
Flammable solids 
(section 2.7)  1, 2 
Self-reactive substances 
and mixtures (section 2.8)Types B, C, 
D, E, F 
Pyrophoric liquids (section 2.9) 1 
Pyrophoric solids (section 
2.10) 1 
Substances and mixtures 
which, in contact with water, emit flammable gases (section 2.12)  1, 2, 3 
Oxidising liquids (section 
2.13) 1, 2, 3 
Oxidising solids (section 
2.14) 1, 2, 3 'P378 Use ... to extinguish . 
Organic peroxides 
(section 2.15) Types B, C, 
D, E, F – if water increases 
risk… .
 Manufacturer/s
upplier to specify 
appropriate media 
 
Explosives (section 2.1)  
 Unstable 
explosives,
Divisions 
1.1, 1.2, 
1.3, 1.4, 1.5
Self-reactive substances and mixtures (section 2.8)  Types A, B
Oxidising liquids (section 
2.13) 1 
Oxidising solids (section 
2.14) 1 P380 Evacuate area. 
Organic peroxides 
(section 2.15) Types A,B 
P381 In case of leakage, 
eliminate all ignition sources. Flammable gases (section 
2.2) 1, 2' 
 
 
(xi) The entry concerning code P301+312 is replaced by the following:  
67 
 'P301 
+ 
P312 IF SWALLOWED: 
Call a POISON CENTER/doctor/...if you feel unwell. Acute toxicity – oral 
(section 3.1)  4 …Manufacturer/supplier 
to specify the appropriate source of emergency medical advice.'  
 
(xii) The entry concerning code P301+P330+P331 is deleted. 
(xiii) The entry concerning code P302+P 334 is replaced by the following: 
'P302 
+ 
P334 IF ON SKIN: Immerse 
in cool water [or wrap in wet bandages]. Pyrophoric liquids (section 
2.9) 1 text in square 
brackets to be used for pyrophoric liquids.' 
 
(xiv)   The entry concerning code  P303+P361+P353 is deleted. 
(xv) The entry concerning code P305+P351+P338 is deleted.  
(xvi)  The entries concerning codes P308+P313, P332+P313, P333+P313 are 
replaced by the following: 
Germ cell mutagenicity 
(section 3.5) 1A, 1B, 2 
Carcinogenicity (section 
3.6) 1A, 1B, 2 
Reproductive toxicity 
(section 3.7) 1A, 1B, 2 'P308 
+ 
P313 IF exposed or 
concerned: Get medical advice/ attention. 
Reproductive toxicity – 
effects on or via lactation (section 3.7) Additional 
category Manufacturer/supplier 
to select medical advice or attention as appropriate. 
P332 
+ 
P313 If skin irritation 
occurs: Get medical advice/ attention. Skin irritation (section 
3.2) 2 -may be omitted 
when P333+P313 is given on the label.  
 Manufacturer/supplier to select medical advice or attention as appropriate.  
P333 
+ 
P313 If skin irritation or 
rash occurs: Get medical advice/attention. Skin sensitisation (section 
3.4) 1, 1A, 1B Manufacturer/supplier 
to select medical advice or attention as appropriate.'  
  
68 
 (xvii)  The following new entry concerning code  P336+P315 is inserted after entry 
concerning code P333+P313: 
'P336 
+ 
P315 Thaw frosted parts 
with lukewarm water. Do not rub affected area. Get immediate medical advice/attention. Gases under pressure 
(section 2.5) Refrigerated 
liquified gas Manufacturer/supplier 
to select medical advice or attention as appropriate.'  
 
(xviii)  The entry concerning code P335+P334 is deleted. 
(xix)  The entry concerning code P337+P 313 is replaced by the following: 
'P337 
+ 
P313 If eye irritation 
persists: Get medical advice/attention. Eye irritation (section 3.3) 2 Manufacturer/supplier 
to select medical advice or attention as appropriate.'  
 
(xx) The entry concerning code P370+P 378 is replaced by the following: 
Flammable liquids 
(section 2.6)  1, 2, 3 
Flammable solids 
(section 2.7)  1, 2 
Self-reactive substances 
and mixtures (section 2.8) Types C, 
D, E, F 
Pyrophoric liquids (section 2.9) 1 
Pyrophoric solids 
(section 2.10) 1 
Substances and mixtures 
which, in contact with water, emit flammable gases (section 2.12)  1, 2, 3 
Oxidising liquids (section 
2.13) 1, 2, 3 
Oxidising solids (section 
2.14) 1, 2, 3 'P370 
+ 
P378 In case of fire: Use ... 
to extinguish. 
Organic peroxides 
(section 2.15) Types C, 
D, E, F – if water increases 
risk. 
 ... Manufacturer/sup-
plier to specify appropriate media.' 
 
  
69 
 (xxi) The following new entries concerning codes P301+P330+P331, 
P302+P335+P334, P303+P361+P353 and  P305+P351+P338 are inserted 
after the entry concerning code P370+P378: 
'P301 + 
P330 + 
P331 IF SWALLOWED: 
Rinse mouth. Do 
NOT induce 
vomiting. Skin corrosion (section 
3.2) 1A, 1B, 
1C  
Pyrophoric solids 
(section 2.10) 1 - text in square 
brackets to be used for 
pyrophoric solids P302 + 
P335 + 
P334 IF ON SKIN: Brush 
off loose particles 
from skin. Immerse 
in cool water [or 
wrap in wet 
bandages]. Substances and 
mixtures which, in 
contact with water, 
emit flammable gases 
(section 2.12) 1, 2 - use only “Immerse in 
cold water”. Text in 
square brackets should 
not be used. 
Flammable liquids 
(section 2.6) 1, 2, 3 P303 + 
P361 + 
P353 IF ON SKIN (or 
hair): Take off 
immediately all 
contaminated 
clothing. Rinse skin 
with water [or 
shower]. Skin corrosion (section 
3.2) 1, 1A, 
1B, 1C text in square brackets 
to be included where 
the 
manufacturer/supplier 
considers it 
appropriatee for the 
specific chemical. 
Skin corrosion (section 
3.2) 1A, 1B, 
1C  
Serious eye 
damage/eye irritation 
(section 3.3) 1 
 P305 + 
P351 + 
P338 IF IN EYES: Rinse 
cautiously with 
water for several 
minutes. Remove 
contact lenses, if 
present and easy to 
do. Continue 
rinsing. Eye irritation (section 
3.3) 2' 
 
 
(xxii)  The entry concerning code P370+P380 is deleted. 
(xxiii)  The entry concerning code P370+P380+ P375 is replaced by the following: 
'P370 
+ 
P380 
+ 
P375 In case of fire: 
Evacuate area. Fight fire remotely due to the risk of explosion. Explosives (section 2.1)  Division 1.4 
- for explosives 
of division 1.4 (compatibility group S) in transport packaging' 
  
70 
 (xxiv)  The following new entries concerning codes P370+P372+P380+P373 and 
P370+P380+P375+[P378] are inserted after the entry concerning code 
P371+P380+P375: 
 
Unstable 
explosives 
and 
divisions 
1.1, 1.2, 
1.3, 1.5  Explosives (section 2.1)  
Division 
1.4 -except for explosives 
of division 1.4 (compatibility group S) in transport packaging.  
Self-reactive substances 
and mixtures (section 2.8)Type A  'P370 
+ 
P372 
+ 
P380 
+  
P373 In case of fire: 
Explosion risk. Evacuate area. DO NOT fight fire when fire reaches explosives 
Organic peroxides 
(section 2.15) Type A  
Self-reactive substances 
and mixtures (section 2.8)Type B P370 
+ 
P380 
+ 
P375 
+ 
[P378] In case of fire: 
Evacuate area. Fight fire remotely due to the risk of explosion. [Use ... to extinguish]. Organic peroxides 
(section 2.15)  Type B – text in square 
brackets to be 
used if water increases risk. 
 ... 
Manufacturer/supplier to specify appropriate media.' 
 
 
(c) Table 6.4 is amended as follows: 
(i)  The entry concerning code P401 is replaced by the following: 
'P401 Store in accordance 
with …  Explosives (section 2.1)  Unstable 
explosives 
and 
Divisions 
1.1, 1.2, 1.3, 
1.4, 1.5 … Manufacturer/
supplier to specify local/regional/ national/international regulations as applicable.'  
 
(ii) The entry concerning code P403 is replaced by the following:  
71 
 Flammable gases (section 
2.2) 1, 2  
Oxidising gases (section 
2.4) 1  
Compressed 
gas  
Liquefied 
gas  
Refrigerated 
Liquefied 
gas  Gases under pressure 
(section 2.5)  
Dissolved 
gas  
Flammable liquids (section 
2.6) 
1, 2, 3 - for flammable 
liquids Category 1 and other 
flammable 
liquids that are volatile and may generate an explosive atmosphere.  
Self-reactive substances 
and mixtures (section 2.8)  
Organic peroxides (section 
2.15) Types A, B, 
C, D, E, F 
 - except for 
temperature controlled self-reactive substances and mixtures or organic peroxides because condensation and consequent freezing may take place. 
Acute toxicity – inhalation (section 3.1) 1, 2, 3 'P403 
Specific target organ 
toxicity – single exposure; respiratory tract  irritation 
(section 3.8) 3 
 Store in a well-
ventilated place. 
Specific target organ 
toxicity – single exposure; narcosis (section 3.8) 3' – if the chemical 
is volatile and may generate a hazardous atmosphere.  
72 
  
(iii) The entry concerning code P406 is replaced by the following: 
'P406 Store in a corrosion 
resistant/... container with a resistant inner liner. Corrosive to metals 
(section 2.16) 
1 - may be omitted 
if P234 is given on the label  
…Manufacturer/s
upplier to specify other compatible materials.'  
 
(iv) The entry concerning code P407 is replaced by the following: 
'P407 Maintain air gap 
between stacks or pallets. Self-heating substances and 
mixtures  (section 2.11) 1, 2'  
 
(v) The entries concerning codes P411, P412, P413, P420 are replaced by the 
following: 
Self-reactive substances 
and mixtures (section 2.8)  Types  
A, B, C, D, 
E, F 'P411 Store at temperatures 
not exceeding …°C/…°F.  
Organic peroxides (section 
2.15) 
Types  
A, B, C, D, 
E, F - if temperature 
control is 
required (according to Annex I, section 2.8.2.4 
or 2.15.2.3 ) or 
if otherwise deemed necessary.  
… 
Manufacturer/supplier to specify temperature using the applicable temperature scale. 
  
73 
 P412 Do not expose to 
temperatures exceeding 50 °C/ 122 °F. Aerosols (section 2.3) 
1, 2, 3 Manufacturer/sup
plier to use 
applicable temperature scale. 
  
74 
 P413 Store bulk masses 
greater than … kg/…lbs at temperatures not exceeding …°C/…°F. Self-heating substances and 
mixtures (section 2.11) 
1, 2 ...
 Manufactu
rer/supplier to specify mass and temperature using applicable scale. 
 
Self-reactive substances 
and mixtures (section 2.8)  Types  
A, B, C, D, 
E, F 
Self-heating substances and mixtures (section 2.11) 1,2 
Oxidising liquids (section 
2.13) 1 
Oxidising solids (section 
2.14) 1 – 
P420 Store separately. 
Organic peroxides (section 
2.15) Types 
A,B,C,D,E,F
'  
 
(vi) The entry concerning code P422 is deleted. 
(vii) The entries concerning codes P403+P233, P403+P235, P410+P403, P410+412 
are replaced by the following: 
Acute toxicity – inhalation 
(section 3.1)  1, 2, 3 
Specific target organ 
toxicity – single exposure; respiratory tract  irritation 
(section 3.8) 3 'P403 
+ 
P233 Store in a well-
ventilated place. Keep container tightly closed. 
Specific target organ 
toxicity – single exposure; narcotic effects (section 3.8) 3 – if the chemical 
is volatile and may generate a hazardous atmosphere.  
75 
 P403 
+ 
P235 Store in a well-
ventilated place. Keep cool. Flammable liquids (section 
2.6) 
 
1, 2, 3 
 For flammable 
liquids Category 1 and other flammable liquids that are volatile and may generate an explosive atmosphere.  
76 
 Compressed 
gas 
Liquefied 
gas P410 
+ 
P403 Protect from sunlight. 
Store in a well-ventilated place. Gases under pressure 
(section 2.5)  
Dissolved 
gas -P410 may be 
omitted for gases filled in transportable gas cylinders in accordance with packing instruction P200 of the UN RTDG, unless those gases are subject to (slow) decomposition or polymerisation. 
P410 
+ 
P412 Protect from sunlight. 
Do not expose to temperatures exceeding 50 °C/122°F. Aerosols (section 2.3) 
1, 2, 3 Manufacturer or 
supplier to use applicable temperature scale.' 
 
(viii) The entry concerning code P411+P235 is deleted. 
(d) Table 6.5 is amended as follows: 
The entries concerning codes P501 and P502 are replaced by the following: 
  
77 
 Explosives (section 2.1)  Unstable 
explosives 
and 
Divisions 
1.1, 1.2, 1.3, 
1.4, 1.5 
Flammable liquids (section 2.6)  1, 2, 3 
Self-reactive substances 
and mixtures  (section 2.8)  Types  
A, B, C, D, 
E, F 
Substances and mixtures which, in contact with water, emit flammable gases (section 2.12) 1, 2, 3 
Oxidising liquids (section 
2.13) 1, 2, 3 
Oxidising solids (section 
2.14) 1, 2, 3 
Organic peroxides (section 
2.15) Types  
A, B, C, D, 
E, F 
Acute toxicity – oral (section 3.1)  1, 2, 3, 4 
Acute toxicity – dermal 
(section 3.1)  1, 2, 3, 4 
Acute toxicity – inhalation 
(section 3.1)  1, 2 'P501 Dispose of 
contents/container to  
... 
Skin corrosion (section 
3.2) 1, 1A, 1B, 
1C ... in accordance 
with local/regional/ national/international regulation (to be specified). 
Manufacturer/supplier 
to specify whether disposal requirements apply to contents, container or both . 
 
  
78 
 Respiratory sensitisation 
(section 3.4) 1, 1A, 1B 
Skin sensitisation (section 
3.4) 1, 1A, 1B 
Germ cell mutagenicity 
(section 3.5) 1A, 1B, 2 
Carcinogenicity (section 
3.6) 1A, 1B, 2 
Reproductive toxicity 
(section 3.7) 1A, 1B, 2 
Specific target organ 
toxicity – single exposure (section 3.8)  1, 2 
Specific target organ 
toxicity – single exposure; respiratory tract  irritation 
(section 3.8) 3 
Specific target organ 
toxicity – single exposure; narcosis (section 3.8) 3 
Specific target organ 
toxicity – repeated exposure (section 3.9) 1, 2 
Aspiration hazard (section 
3.10)  1 
Hazardous to the aquatic 
environment – acute aquatic hazard(section 4.1)  1   
Hazardous to the aquatic 
environment – chronic aquatic hazard (section 4.1) 
 1, 2, 3, 4 
 
P502 Refer to manufacturer 
or supplier for information on recovery or recycling  Hazardous to the ozone 
layer (section 5.1) 1'  
 
    
79 
 (3) Part 2 is amended as follows: 
[Note to DGT: All language vers ions need to be added and their full synchronicity with the 
language versions in Part 1 of Annex IV as translated by DGT (after the ISC) ensured.] 
(a) Table 1.2 is amended as follows: 
(i) The entry concerning code P220 is replaced by the following: 
'P220 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Keep away from clothing and other combustible materials. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL   
80 
 'P220 Language  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(ii) The entry concerning code P221 is deleted. 
(iii) The entry concerning code P231 is replaced by the following: 
'P231 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Handle and store contents under inert gas/… 
 FR  
 GA   
81 
 'P231 Language  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(iv) The entry concerning code P234 is replaced by the following: 
'P234 Language  
 BG  
 ES  
 CS  
 DA   
82 
 'P234 Language  
 DE  
 ET  
 EL  
 EN Keep only in original packaging. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
  
83 
 (v) The entry concerning code P240 is replaced by the following: 
'P240 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Ground and bond container and receiving equipment. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO   
84 
 'P240 Language  
 SK  
 SL  
 FI  
 SV ' 
 
(vi) The entry concerning code P241 is replaced by the following: 
'P241 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Use explosion-proof [electrica l/ventilating/lighting/…]equipment. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT   
85 
 'P241 Language  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(vii) The entry concerning code P242 is replaced by the following: 
'P242 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Use non-sparking tools.  
86 
 'P242 Language  
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(viii)  The entry concerning code P243 is replaced by the following: 
'P243 Language  
 BG  
 ES   
87 
 'P243 Language  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Take action to prev ent static discharges. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI   
88 
 'P243 Language  
 SV ' 
 
(ix) The entry concerning code P250 is replaced by the following: 
'P250 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Do not subject to grinding/shock/friction/… . 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL   
89 
 'P250 Language  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(x) The entry concerning code P263 is replaced by the following: 
'P263 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Avoid contact during pr egnancy and while nursing. 
 FR  
 GA  
 HR   
90 
 'P263 Language  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(xi) The entry concerning code P282 is replaced by the following: 
'P282 Language  
 BG  
 ES  
 CS  
 DA  
 DE   
91 
 'P282 Language  
 ET  
 EL  
 EN Wear cold insulating gloves and either face shield or eye 
protection. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(xii) The entry concerning code P283 is replaced by the following:  
92 
 'P283 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Wear fire resistant or flame retardant clothing. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK   
93 
 'P283 Language  
 SL  
 FI  
 SV ' 
 
(xiii)  The entry concerning code P231+P 232 is replaced by the following: 
'P231+P
232 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Handle and store contents under inert gas/… . Protect from 
moisture. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT   
94 
 'P231+P
232 Language  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(xiv)  The entry concerning code P235+P410 is deleted. 
(b) Table 1.3 is amended as follows: 
(i) The entry concerning  code P312 is replaced by the following: 
'P312 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET   
95 
 'P312 Language  
 EL  
 EN Call a POISON CENTER/doc tor/… if you feel unwell. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(ii) The entry concerning code P334 is replaced by the following: 
'P334 Language   
96 
 'P334 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Immerse in cool water [or wrap in wet bandages]. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK   
97 
 'P334 Language  
 SL  
 FI  
 SV ' 
 
(iii) The entry concerning code P353 is replaced by the following: 
'P353 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Rinse skin with water [or shower]. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU   
98 
 'P353 Language  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(iv) The entry concerning code P372 is replaced by the following: 
'P372 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Explosion risk. 
 FR   
99 
 'P372 Language  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
(v) The entry concerning code P374 is deleted. 
(vi) The entry concerning code P381 is replaced by the following: 
'P381 Language  
 BG  
 ES  
 CS   
100 
 'P381 Language  
 DA  
 DE  
 ET  
 EL  
 EN In case of leakage, el iminate all ignition sources. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV '  
101 
  
(vii) The entry concerning code P301+P 312 is replaced by the following: 
'P301+P
312 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN IF SWALLOWED: Call a POIS ON CENTER/doctor/… if you 
feel unwell. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL   
102 
 'P301+P
312 Language  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(viii)  The entry concerning code P301+P330+P331 is deleted.   
(ix) The entry concerning code P302+P 334 is replaced by the following: 
'P302+P
334 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN IF ON SKIN: Immerse in cool water [or wrap in wet bandages]. 
 FR  
 GA   
103 
 'P302+P
334 Language  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(x) The entry concerning code P303+P361+P353 is deleted. 
(xi) The entry concerning a new code P336+ P315 is inserted after P333+P313: 
'P336+P
315 Language  
 BG  
 ES   
104 
 'P336+P
315 Language  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Thaw frosted parts with lukewarm water. Do not rub affected area. 
Get immediate medical advice/attention. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL   
105 
 'P336+P
315 Language  
 FI  
 SV ' 
 
(xii)  The entry concerning code  P305+P351+P338 is deleted. 
(xiii)  The entry concerning code P335+P334 is deleted. 
(xiv) The following new entries concerning codes P301+P330+P331, 
P302+P335+P334, P303+P361+P353 and P305+P351+P338 are inserted after 
the entry concerning code P370+P378: 
'P301+P
330+P33
1 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. 
 FR  
 GA  
 HR  
 IT   
106 
 'P301+P
330+P33
1 Language  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
'P302+P
335+P33
4 Language  
 BG  
 ES  
 CS  
 DA  
 DE   
107 
 'P302+P
335+P33
4 Language  
 ET  
 EL  
 EN IF ON SKIN: Brush off loose particles from skin. Immerse in cool 
water [or wrap in wet bandages]. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
  
108 
 'P303+P
361+P35
3 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN IF ON SKIN (or hair): Take off immediately all contaminated 
clothing. Rinse skin with water [or shower]. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT   
109 
 'P303+P
361+P35
3 Language  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
'P305+P
351+P33
8 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN IF IN EYES: Rinse cautiously w ith water for several minutes. 
Remove contact lenses, if pres ent and easy to do. Continue 
rinsing. 
 FR  
 GA  
 HR   
110 
 'P305+P
351+P33
8 Language  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
(xv) The entry concerning code P370+P380 is deleted. 
(xvi) The following new entries concerning codes P370+P372+P380+P373 and 
P370+P380+P375 [+P378] are insert ed after the entry concerning 
P371+P380+P375: 
'P370+P
372+P38
0+P373 Language  
 BG  
 ES   
111 
 'P370+P
372+P38
0+P373 Language  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN In case of fire: Explosion risk. Evacuate area. DO NOT fight fire 
when fire reaches explosives. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK   
112 
 'P370+P
372+P38
0+P373 Language  
 SL  
 FI  
 SV ' 
 
 
'P370+P
380+P37
5[+P378
] Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN In case of fire: Evacuate area. Fight fire remotely due to the risk of 
explosion. [Use … to extinguish]. 
 FR  
 GA  
 HR  
 IT   
113 
 'P370+P
380+P37
5[+P378
] Language  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(c) Table 1.4 is amended as follows: 
(i) The entry concerning code P401 is replaced by the following: 
'P401 Language  
 BG  
 ES  
 CS  
 DA   
114 
 'P401 Language  
 DE  
 ET  
 EL  
 EN Store in accordance with… . 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
  
115 
 (ii) The entry concerning code P406 is replaced by the following: 
'P406 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Store in a corrosion resistant/… c ontainer with a resistant inner 
liner. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT   
116 
 'P406 Language  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(iii)The entry concerning code P407 is replaced by the following: 
'P407 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Maintain air gap between stacks or pallets. 
 FR  
 GA  
 HR  
 IT  
 LV   
117 
 'P407 Language  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(iv) The entry concerning code P420 is replaced by the following: 
'P420 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL   
118 
 'P420 Language  
 EN Store separately. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV ' 
 
(v) The entry concerning code P422 is deleted. 
(vi) The entry concerning code P411+P235 is deleted. 
(d) Table 1.5 is amended as follows: 
The entry concerning code P502 is replaced by the following:  
119 
 'P502 Language  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Refer to manufacturer or supplier for information on recovery or 
recycling. 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO   
120 
 'P502 Language  
 SK  
 SL  
 FI  
 SV ' 
 
  
121 
 ANNEX V  
 
In Annex V to Regulation (EC) No 1272/2008, in Part 2, Table 2.2 is replaced by the 
following: 
'2.2. SYMBOL: CORROSION 
Pictogram 
(1) Hazard class and hazard category 
(2) 
GHS05 
 Section 3.2  
Skin corrosion, hazard category 1 and sub-categories 1A, 1B, 1C Section 3.3
 
Serious eye damage, hazard category 1 
'  
122 
 ANNEX VI  
 
Part 1 of Annex VI to Regulation (EC) No 1272/2008 is amended as follows: 
(1) In Table 1.1 the row concerning Skin corrosi on/irritation is repl aced by the following: 
 
'Skin corrosion/irritation Skin Corr. 1 
Skin Corr. 1A Skin Corr. 1B Skin Corr. 1C Skin Irrit. 2' 
 
(2) In section 1.1.3, Note U is replaced by the following: 
'Note U (Table 3.1): When put on the market gases have to be classi fied as ‘Gases under pre ssure’, in one of the 
groups compressed gas, liquefied gas, refrigerat ed liquefied gas or di ssolved gas. The group 
depends on the physical state in which the gas is  packaged and therefore has to be assigned 
case by case. The following codes are assigned: 
Press. Gas (Comp.)  
Press. Gas (Liq.)  
Press. Gas (Ref. Liq.)  Press. Gas (Diss.) Aerosols shall not be classified as gases under pressure (See Annex I, Part 2, Section 2.3.2.1, 
Note 2).'  
123 
 ANNEX VII  
 
Annex VII to Regulation (EC) No 1272/2008 is amended as follows: 
(1) In Table 1.1 the rows concerning C; R34 a nd C; R35 are replaced by the following: 
'C; R34   Skin Corr. 1 H314 (2) 
C; R35  Skin Corr. 1A H314'  
 
(2) Note 2 to Table 1.1 is replaced by the following: 
'Note 2 
Going back to original data, may not result  in a possibility to  distinguish between 
Category 1B or 1C, since the exposure period has normally been up to 4 hours according to 
Regulation (EC) No 440/2008. In these cases, Cate gory 1 shall be assigned. However, when 
data are derived from tests following a sequential approach as foreseen in the Regulation (EC) 
No 440/2008, further sub-categorisation into Category 1B or Category 1C shall be 
considered.'