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 EN 
 
ANNEX  
Common Name IUPAC Name 
Identification Numbers Minimum degree of 
purity of the active 
substance1  Date of 
approval Expiry date 
of approval Product 
type Specific conditions 
Clothianidin IUPAC Name :  
(E)-1-(2-Chloro-1,3-thiazol-5-
ylmethyl)-3-methyl-2- Nitroguanidine 
EC n° : 433-460-1 
CAS n° : 210880-92-5 93% w/w 1 October 
2016 30 
September 
2026 18 Clothianidin is considered a candidate for substitution in 
accordance with Article 10(1)(d) of Regulation (EU) No 528/2012. 
The product assessment shall pay particular attention to the 
exposures, the risks and the e fficacy linked to any uses 
covered by an application for authorisation, but not 
addressed in the Union level risk assessment of the active 
substance. 
For biocidal products, authorisations are subject to the 
following conditions: 
(1) For industrial or professional users, safe operational 
procedures, appropriate organisational and technical risk mitigation measures shall be established. Where exposure cannot be reduced to an acceptable level by other means, products shall be used with 
                                                            
1 The purity indicated in this column was the minimum degree of purity of the active substance us ed for the evaluation made in a ccordance with Article 16(2) of 
Directive 98/8/EC. The active subs tance in the product placed on the market can be of equal or different purity if it has been proven technically equivalent with the 
evaluated active substance.  
 
2 
 Common Name IUPAC Name 
Identification Numbers Minimum degree of 
purity of the active 
substance1  Date of 
approval Expiry date 
of approval Product 
type Specific conditions 
appropriate personal protective equipment. 
(2) Products shall not be authorized for uses in animal 
housings where exposure to a STP or direct emission to surface water cannot be prevented, unless data are submitted demonstrating that the product will meet the requirements of Article 19 and Annex VI to Regulation No 528/2012, if necessary by the application of appropriate risk mitigation measures. 
(3) Due to the risks identified  for the soil compartment, 
products shall not be authorized for uses in animal housings others than for beef cattle, unless data are submitted demonstrating that the product will meet the requirements of Article 19 and Annex VI to Regulation No 528/2012, if necessary by the application of appropriate risk mitigation measures. 
(4) For products that may lead to residues in food or 
feed, the need to set new or to amend existing 
maximum residue levels (MRLs) in accordance with 
Regulation (EC) No 470/2009 of the European 
Parliament and of the Council
2 or Regulation (EC) No 
                                                                                                                                                                                                                                                                                                          
2  Regulation (EC) No 470/2009 of the European Parliament and of the Council of 6 May 2009 laying down Community procedures for the establishment of residue limits of 
pharmacologically active substances in foodstuffs of animal origin, repealing Council Regulation (EEC) No 2377/90 and amending Directive 2001/82/EC of the European 
Parliament and of the Council and Regulation (EC) No 726/2004 of the European Parliament and of the Council (OJ L 152, 16.6.200 9, p. 11). 
3  Regulation (EC) No 396/2005 of the European Parliament and of the Council of 23 February 2005 on maximum residue levels of pe sticides in or on food and feed of plant 
and animal origin and amending Council Directive 91/414/EEC (OJ L 70, 16.3.2005, p. 1).  
 
3 
 Common Name IUPAC Name 
Identification Numbers Minimum degree of 
purity of the active 
substance1  Date of 
approval Expiry date 
of approval Product 
type Specific conditions 
396/2005 of the European Parliament and of the 
Council3 shall be verified, and any appropriate risk 
mitigation measures shall be taken to ensure that the 
applicable MRLs are not exceeded.