1 
 EN 
 
ANNEXES I – VI 
 
ANNEX I  
 
Annex I to Regulation (EC) No 1272/2008 is amended as follows:  
 
1. Part 1 is amended as follows:  
 
(a) In section 1.1.2.2.2 Table 1.1 is replaced by the following:  
 
‘Table 1.1  
 
Generic cut -off values  
 
Hazard class   
Generic cut -off values to be taken 
into account  
 
Acute Toxicity:   
- Category 1 -3 
- Category 4  0,1 % 
1 % 
Skin corrosion/Irritation  1 %(1) 
Serious damage to eyes/eye irritation  1 %(2) 
Specific target organ toxicity, single 
exposure, Category 3  1 %(3) 
Aspiration toxicity  1 % 
Hazardous to Aquatic Environment   
- Acute Category 1  0,1 %(4) 
- Chronic Category 1  0,1 %(4) 
- Chronic Category 2 -4 1 %’ 
(1) Or < 1  % where relevant, see 3.2.3.3.1 . 
(2) Or < 1  % where relevant, see 3.3.3.3.1 . 
(3) Or <1  % where relevant, see 3.8.3.4. 6. 
(4) Or < 0,1  % where relevant, see 4.1.3.1 .  
 
 
(b) Section 1.1.3.7 . is replaced by the following:  
 
‘1.1.3.7 .  Aerosols  
In the case of the classification of mixtures covered by sections 3.1, 3.2, 3.3, 3.4, 
3.8 and 3.9, an aerosol form of a mixture shall be classified in the same hazard  
2 
 category as the tested  non-aerosolised form of the mixture, provided that the 
added prope llant does not affect the hazardous properties of the mixture upon 
spraying .’ 
 
(c) Section 1.3.2.1 . is replaced by the following:  
 
‘1.3.2.1 . If propane, butane and liquefied petroleum gas or a mixture containing these 
substances  classified in accordance with the criteria of this Annex, is placed on 
the market in closed refillable cylinders  or in non -refillable cartridges within the 
scope of EN 417 as fuel gases which are only released for combustion (current 
edition of EN 417, relating to ‘Non -refillable metallic gas cartridges for 
liquefied petroleum gases, with or without a valve, for use with portable 
appliances; construction, inspection, testing and marking’), these cylinders or 
cartridges need  be labelled only with the appropriate pictogram and the ha zard 
and precautionary statements concerning flammability. ’ 
2. Part 2 is amended as follows:  
(a) In section 2.1.1 .1., point  (c) is replaced by the following :  
'(c)  substances, mixtures and articles not mentioned in points  (a) and (b) above , 
which  are manufactured with the view to producing a practical explosive or 
pyrotechnic effect. ’ 
(b) In section 2.1.2.2 ., point  (f) is replaced by the following:  
 
‘(f) Division 1.6 Extremely insensitive articles which do not have a mass  
explosion  hazard:  
 
 - articles  which predominantly contain extremely insensitive 
substances or  mixtures ; 
 -  and which demonstrate a negligible probability of accidental 
initiation or propagation. ’ 
(c) In section 2.1.4.1 ., the third  paragraph  is replaced by the following:   
 
‘Some explosive substances and mixtures are wetted with water or alcohols, 
diluted with other substances or dissolved or suspended in water or other liquid 
substances to suppress or reduce their explosives properties. They may be a 
candidate for classification a s desensitised explosives (see Section 2.1 7).’ 
 
(d) In section 2.1.4.1 ., figure 2.1.3 is replaced  by the following:  
‘ 
 
 
 
 
 
 
 
 
 
 
 
  
3 
  
 1See Chapter 3.3 of the UN RTDG , Model Regulations for details. ’ 
 
(e) Section 2.1.4.3 . is amended as follows:  
 
(i)  the introductory wording is replaced by the following : 
 
‘2.1.4.3 . The acceptance procedure for the hazard class “explosives” need not be  
  applied if: ’ 
  
4 
 (ii) point (c)  is replaced by the following:  
 
‘(c) For an organic substance, or a homogenous mixture of organic substances,  
 containing a  chemical group (or groups) associated with explosive  
  properties:  
  – the exothermic decomposition energy is less than 500 J/g, or  
  – the onset of exothermic decomposition is 500  ºC or above  
as indicated in Table 2.1.3 .’ 
 
(iii) Table 2.1.3  is added to 2.1.4.3  (c): 
 
‘Table 2.1.3   
 
Decision to apply the acceptance procedure for the hazard class “Explosives” for an 
organic substance or a homogenous mixture of organic substances  
 
Decomposition 
energy  
(J/g) Decomposition 
onset temperature  
(°C) Apply acceptance 
procedure?  
(Yes/No)  
< 500  < 500  No 
< 500  ≥ 500  No 
≥ 500  < 500  Yes 
≥ 500  ≥ 500  No 
 
The exothermic decomposition energy may be determined using a suitable calorimetric 
technique (see section 20.3.3.3 of the UN RTDG , Manual of Tests and Criteria ).’ 
 
(f) In section 2.2 . the title is replaced by the following :  
 
‘2.2.  Flammable gases ’  
(g) In section 2.2 ., section 2.2.1. is replaced by the following : 
 
‘2.2.1.1.  Flammable gas means a gas or gas mixture having a flammable range with air at  
20 °C and a standard pressure of 101, 3 kPa.  
 
2.2.1.2 . A pyrophoric gas means  a flammable gas that is liable to ignite spontaneously in 
air at a temperature of 54  ºC or below. ’ 
 
2.2.1. 3.  A chemically unstable gas means a flammable gas that is able to react explosively 
even in the  absence of air or oxygen. ’ 
 
(h) Section 2.2.2.1 . and 2.2.2.2 . are replaced by the following:  
 
‘2.2.2.1 . A flammable gas is classified in Category 1A, 1B or 2 in accordance with Table 
2.2.1 . Flammable gases that are pyrophoric and/or chemically unstable are 
always classified in Category 1A .’ 
 
 Table 2.2.1:  Criteria for  categorisation of flammable gases  
Category  Criteria  
1A Flammable gas  Gases, which at 20  °C and a standard pressure of 101,3  kPa:  
5 
 (a) are ignitable when in a mixture of 13  % or less by 
volume in air; or  
(b) have a flammable range with air of at least 12 
percentage points regardless of the lower flammability 
limit  
unless data show they meet the criteria for Category 1B  
Pyrophoric gas  Flammable gases that ignite spontaneously in air at a 
temperature of 54  ºC or below  
Chemically 
unstable gas  A Flammable gases which are chemically unstable  at 20  °C and a 
standard pressure of 101 ,3 kPa 
B Flammable gases which are chemically unstable at a 
temperature greater than 20  °C and/or a pressure greater than 
101,3 kPa 
1B Flammable gas  Gases which meet the flammability criteria for Category 1A, 
but which are not pyrophoric, nor chemically unstable, and 
which have at least either:  
(a) a lower flammability limit of more than 6  % by 
volume in air; or  
(b) a fundamental burning velocity of less than 10 cm/s;  
2 Flammable gas  Gases, other than those of Category 1A or 1B, which, at 20  °C 
and a standard pressure of  101,3 kPa, have a flammable range 
while mixed in air  
. 
NOTE 1:  Aerosols shall  not be classified as flammable gases. See Section  2.3.  
NOTE 2: In the absence of data allowing classification into Category 1B, a flammable gas that meets the 
criteria for Category 1A is classified by default in Category 1A.  
NOTE 3:  Spontaneous ignition for pyrophoric gases is not always immediate, and there may be a  delay.  
NOTE 4:  In the absence of data on its pyrophoricity, a flammable gas mixture shall  be classified as a 
pyrophoric gas if it contains more than 1% (by volume) of pyrophoric component(s ).’ 
 
 
(i) In section 2.2.3 ., Table 2.2. 3. is replaced  by the following :  
6 
 ‘Table 2.2. 2 
Label elements for flammable gases  
 Category 1A  Gases categorised as 1A by meeting pyrophoric or 
unstable gas A/B criteria  Category 1B  Category 2  
 
Pyrophoric gas  Chemically unstable gas    
Category A  Category B  
GHS Pictogram  
     No pictogram  
Signal Word  Danger  Danger  Danger  Danger  Danger  Warning  
Hazard Statement  H220: 
Extremely 
flammable gas  H220: Extremely 
flammable gas. H232 
May ignite 
spontaneously  if 
exposed to air  H220: 
Extremely 
flammable 
gas. H230: 
May react 
explosively 
even in the 
absence of 
air H220: 
Extremely 
flammable 
gas. H231: 
May react 
explosively 
even in the 
absence of 
air at 
elevated 
pressure 
and/or 
temperature  H221: 
Flammable 
gas H221:  Flammable 
gas 
Precautionary 
Statement 
Prevention  P210  P210  
P222  
P280  P202  
P210  P202  
P210  P210  P210  
Precautionary 
Statement P377  P377  P377  P377  P377  P377  
 
7 
  
 
 
 
 
 
 
 
The classification procedure is set out in the following decision logic ( see Figure 2.2. 1).’ 
 Response  P381  P381  P381  P381  P381  P381  
Precautionary 
Statement Storage  P403  P403  P403  P403  P403  P403  
 
Precautionary 
Statement 
Disposal         
8 
 (j)  In section 2.2.3 ., the following  paragraph is added after Table 2.2.2 .: 
 
‘If a flammable gas or gas mixture is classified as pyrophoric and/or chemically  
unstable, then all relevant classification(s) shall  be communicated on the safety data 
sheet as specified in Annex II of Regulation (EC) No 1907/2006 , and the relevant 
hazard c ommunication elements included on the label. ’  
 
(k) In section 2.2 .3., Figure 2.2. 1. is replaced with the following:   
‘Figure 2.2.1  
Flammable  gases   
 
 
1In the absence of data on its pyrophoricity, a flammable gas mixture shall be classified as a pyrophoric gas if it 
contains more than 1% (by volume) of pyrophoric component(s).    
9 
 
 
’ 
 
(l) In section 2.2.3 ., Figure 2.2.2 . is deleted . 
 
(m) Section 2.2.4 . is amended as follows : 
Section 2.2.4.1 . is replaced by the following : 
‘2.2.4.1 . Flammability shall be determined by tests or, for mixtures where there are 
sufficient data available, by calculation in accordance with the methods adopted 
by ISO (see ISO 10156 as amended, “Gases and gas mixtures — Determination of 
fire potential and oxidising ability for the selection of cylinder valve outlets" and, 
if using fundamental burning velocity for Category 1B, see ISO 817 as amended 
"Refrigerants -Designation and safety  classification, Annex C: - Method of test for 
burning velocity measurement of flammable gases"). Instead of the test apparatus 
according to ISO 10156 as amended, the test apparatus for the tube method 
according to clause 4.2 of EN 1839 as amended (Determin ation of explosion 
limits of gases and vapours) may be used.’  
The following s ections 2.2.4.2 . and 2.2.4.3 . are inserted :  
 
‘2.2.4.2 .  Pyrophoricity shall be determined at 54  °C in accordance with either IEC 60079 -
20-1 ed1.0  (2010 -01) “Explosive atmospheres – Part 20 -1: Material characteristics  
10 
 for gas and vapour  classification – Test methods and data” or DIN 51794 
“Determining the ignition temperature of  petroleum products”.  
 
2.2.4.3 .  The classification procedure for pyropho ric gases need not be applied when 
experience in  production or handling shows that the substance does not ignite 
spontaneously on coming into contact with air at a temperature of 54  ºC or below. 
Flammable gas mixtures, which have not been tested for pyrophoricity and 
contain more than one percent pyrophoric components, shall be classified as a 
pyrophoric gas.  Expert judgement on the properties and physical hazards of 
pyrophoric gases and their mixtures shall be used in assessing the need for 
classifi cation of flammable gas mixtures containing one percent or less pyrophoric 
components.  In this case, testing need only be considered if expert judgement 
indicates a need for additional data to support the classification process. ’ 
(n) Section 2.2.4.2 . is renumbered as follows:  
 
‘2.2.4.4 .’ 
 
(o)  The text before paragraphs (a) to (d) in section  2.6.4.2 . is replaced by the following:  
 
‘2.6.4.2 .  In the case of mixtures1 containing known flammable liquids in defined 
concentrations, although they may contain no n-volatile components  e.g. polymers, 
additives, the flash point need not be determined experimentally if the calculated 
flash point of the mixture, using the method given in 2.6.4.3 below, is at least 5  
°C2 greater than the relevant classification criterion and provided that:  
1Up to now, the calculation method is validated for mixtures containing up to six volatile components. These 
components may be flammable liquids like hydrocarbons, ethers, alcohols, esters (except acrylates), and water. 
It is h owever not yet validated for mixtures containing halogenated, sulphurous, and/or phosphoric compounds 
as well as reactive acrylates.  
2If the calculated flash point is less than 5 °C greater than the relevant classification criterion, the calculation 
method  may not be used and the flash point shall be determined experimentally. ’ 
 
(p) Section 2.7.2.2 . is replaced by the following:  
 
‘2.7.2.2 .  Powders of metals or metal alloys shall be classified as flammable solids when 
they can be ignited and the reaction sp reads over the whole length of the sample 
(100 mm) in 10 min or less. ’ 
(q) In section 2.12 .2.1. Table 2.12.1 . is replaced by the  following:  
 
 
‘Table 2.12.1  
Criteria for substances and mixtures, which  in contact with water, emit flammable gases  
 
Category  Criteria  
1 Any substance or mixture which reacts vigorously with water at ambient 
temperatures and demonstrates generally a tendency for the gas produced to 
ignite spontaneously, or which reacts readily with water at ambient 
temperatures such that the rat e of evolution of flammable gas is equal to or 
greater than 10 litres per kilogram of substance over any one minute.  
2 Any substance or mixture which reacts readily with water at ambient 
temperatures such that the maximum rate of evolution of flammable gas is 
equal to or greater than 20 litres per kilogram of substance per hour, and  
11 
 which does not meet the criteria for Cat egory 1.  
3 Any substance or mixture which reacts slowly with water at ambient 
temperatures such that the maximum rate of evolution of flammable gas is 
greater than 1 litre per kilogram of substance per hour, and which does not 
meet the criteria for Catego ries 1 and  2. 
Note:  
The test shall be performed on the substance or mixture in its physical form as presented. If, for example, for the 
purposes of supply or transport, the same chemical is to be presented in a physical form different from that 
which was tested and which is considered likely to materially alter its performance in a classification test, the 
substance must also be tested in the new form. ’ 
 
(r) The following section  2.17. is added :  
 
‘2.17.  Desensitised explosives  
2.17.1 .  Definitions and general considerations  
 
2.17.1.1 . Desensitised  explosives are solid or liquid explosive substances or mixtures which 
are phlegmatised  to suppress their explosive properties in such a manner that they 
do not mass explode and do not burn  too rapidly and ther efore may be exempted 
from the hazard class “Explosives” ( see also paragraph 3 in section 2.1.4.1 )1 
 
1 Unstable explosives as defined in Section  2.1 can also be stabili sed by desensiti sation and consequently may be 
classified as desensiti sed explosives, provided all criteria of Section  2.17 are met. In this case the desensiti sed 
explosive shall  be tested according to test series 3 (Part I of the UN RTDG , Manual of Tests and Criteria) 
because information about its sensitiveness to mechanical  stimuli is likely to be important for determining 
conditions for safe handling and use. The results shall  be communicated in the safety data sheet.   
 
2.17.1.2 . The hazard class of desensitised  explosives comprises:  
(a)  Solid desensitised  explosives: expl osive substances or mixtures, which  are wetted 
with water or alcohols or are diluted with other substances, to form a 
homogeneous solid mixture to suppress their explosive properties.  
NOTE: This includes desensiti sation achieved by formation of hydrates of  the substances.  
(b)  Liquid desensitised  explosives: explosive substances or mixtures, which  are 
dissolved or suspended in water or other liquid substances, to form a 
homogeneous liquid mixture to suppress their explosive properties.  
2.17.2 . Classificati on criteria  
2.17.2.1 . Any explosive while in a desensiti sed state shall be considered in this class unless, 
in that state:  
(a) It is intended to produce a practical explosive or pyrotechnic effect;  
(b) It has a mass explosion hazard according to test series 6 (a) or 6 (b) or the 
corrected burning rate according to the burning rate test described in part V, 
subsection 51.4 of the UN RTDG , Manual of Tests and Criteria  is greater 
than 1200 kg/min; or  
(c) The exothermic decomposition energy is less than 300 J/g.   
12 
 NOTE 1 : Substances or mixtures, which  meet the criterion (a) or (b) in their 
desensitised  state shall be classified as explosives (see Section 2.1). Substances or 
mixtures which meet the criterion ( c) may fall within the scope of other physical 
hazard classes.  
NOTE 2: The exothermic decomposition energy may be estimated using a suitable 
calorimetric technique (see section 20, sub -section 20.3.3.3 in Part II of the UN 
RTDG , Manual of Tests and Criteria).    
2.17.2.2 . Desensitised  explosives shall be classified and packaged for supply and use in one 
of the four categories of this class depending on the corrected burning rate (A c) 
using the test “ burning rate test (external fire)”  described in Part  V, sub -section 
51.4 of the UN RTDG , Manual of Tests and Criteria , according to Table 2.17.1:  
Table 2.17.1 . 
Criteria for desensitised  explosives  
 
Category  Criteria  
1 Desensitised  explosives with a corrected burning rate (A C) equal to or 
greater than 300 kg/min but not more than 1200 kg/min  
2 Desensitised  explosives with a corrected burning rate (A C) equal to or 
greater than 140 kg/min but less than 300  kg/min  
3 Desensitised  explosives with a corrected burning rate (A C) equal to or 
greater than 60 kg/min  but less than 140 kg/min  
4 Desensitised  explosives with a corrected burning rate (A C) less than 
60 kg/min  
 
Note 1: Desensitised  explosives shall  be prepared so that they remain homogeneous and do not 
separate during normal storage and handling, particul arly if desensitised  by wetting. The 
manufacturer/supplier shall  give information in the safety data sheet about the shelf -life and 
instructions on verifying desensiti sation. Under certain conditions the content of desensiti sing 
agent (e.g. phlegmatiser , wetting agent or treatment) may decrease during supply and use, and 
thus, the hazard potential of the desensitised  explosive may increase. In addition, the safety data 
sheet shall  include advice on avoiding increased fire, blast or protection hazards whe n the 
substance or mixture is not sufficiently desensitised .  
 
Note  2: Explosive properties of desensitised  explosives shall  be determined by test series 2 of the 
UN RTDG , Manual of Tests and Criteria, and shall  be communicated in the safety data sheet.  
Note 3: For the purposes of storage, supply and use, desensitised explosives do not fall 
additionally within the scope of Sections 2.1 (explosives), 2.6 (flammable liquids) and 2.7 
(flammable solids).  
 
2.17.3 . Hazard communication  
Label elements shall be used for liquid or solid substances or mixtures meeting 
the criteria for classification in this hazard class in accordance with Table 2.17.2.  
 
 
 
 
  
13 
 Table 2.17.2 . 
Label elements for desensitised explosives  
 
 Category 1  Category 2  Category 3  Category 4  
GHS 
Pictogram  
    
Signal word  Danger  Danger  Warning  Warning  
Hazard 
statement  H206 Fire, blast 
or projection 
hazard; 
increased risk 
of explosion if 
desensiti sing 
agent is 
reduced  H207 Fire or 
projection 
hazard; 
increased risk of 
explosion if 
desensiti sing 
agent is reduced  H207 Fire or 
projection 
hazard; 
increased risk 
of explosion if 
desensiti sing 
agent is 
reduced  H208: Fire 
hazard; 
increased risk 
of explosion if 
desensiti sing 
agent is 
reduced  
Precautionary 
statement  
Prevention  P210  
P212  
P230  
P233  
P280  P210  
P212  
P230  
P233  
P280  P210  
P212  
P230  
P233  
P280  P210  
P212  
P230  
P233  
P280  
Precautionary 
Statement 
Response  P370  + 
P380 + 
P375  P370  + 
P380 + 
P375  P370  + 
P380 + 
P375  P371  + 
P380  + 
P375  
Precautionary 
Statement 
Storage   
P401   
P401   
P401   
P401  
Precautionary 
Statement 
Disposal   
P501   
P501   
P501   
P501  
 
2.17.4 . Additional classification considerations   
 
 
14 
 
  
15 
 
 
 
2.17.4.1 . The classification procedure for desensitised  explosives does not apply if:  
 
(a) The substances or mixtures contain no explosives according to 
the criteria in Section  2.1; or  
 
 (b) The exothermic decomposition energy is less than 300 J/g.  
 
2.17.4.2 .  The exothermic decomposition energy shall  be determined using the 
explosive already desensitised  (i.e.: the homogenous solid or liquids mixture 
formed by the explosive and the substance(s) used to suppress its explosive 
properties). The exothermic decomposition energy may be estimated using a 
suitable calorimetric technique (see Section 20, sub -section 20.3.3.3 in Part 
II of the UN RTDG , Manual of Tests and Criteria ).’ 
 
3. Part 3 is amended as follows:  
 
(a) Section 3.1.1 .1. is replaced by the following:  
 
‘3.1.1.1 . Acute toxicity  means  serious adverse health effects (i.e., lethality) occurring after 
a single or short -term oral, dermal or inhalation exposure to a substance or mixture. ’ 
 
(b) In section 3.1.2 .1., the introductory paragraph  is replaced  by the following:   
16 
  
‘3.1.2.1 . Substances can be allocated to one of four hazard categories based on acute 
toxicity by the oral, dermal or inhalation route according to the numeric cut -
off criteria as shown in the table below.  Acute toxicity values are expressed 
as (approximate) LD 50 (oral, dermal) or LC 50 (inhalation) values or as acute 
toxicity estimates (ATE). While some in vivo  methods determine LD 50/LC 50 
values directly, other newer in vivo  methods (e.g. using fewer animals) 
consider other indicators of acute toxicity, such as signi ficant clinical signs 
of toxicity, which are  used by reference to assign the hazard category.  
Explanatory notes are shown following Table 3.1.1. ’ 
(c) In section 3.1.2.1.  the title of Table 3.1.1 . is replaced by the follow ing:  
 
‘Table 3.1.1 . 
Acute toxicity  estimate (ATE) values and criteria for acute toxicity hazard 
categories .’ 
 
(d) Section 3.2.1.1 . is replaced by the following :  
 
‘3.2.1.1 . Skin corrosion  means  the production of irreversible damage to the skin; 
namely, visible necrosis through the epidermis and into the dermis occurring 
after exposure to a substance or mixture.  
 
Skin irritation  means  the production of reversible damage to the skin 
occurring after exposure to a substance or mixture .’ 
 
(e) Section 3.3.1.1 . is replaced by the following :  
 
‘3.3.1.1 . Serious eye damage  means  the production of tissue damage in the eye, or 
serious physical decay of vision, which is not fully reversible, occurring 
after exposure of the eye to a substance or mixture.  
Eye irritation  means the production of changes in the eye, which are fully 
reversible, occurring after the exposure of the eye to a substance or 
mixture. ’ 
 
(f) Section 3 .4.1.1 . is replaced by the following :  
 
‘3.4.1.1 . Respiratory sensiti sation means  hypersensitivity of the ai rways occurring 
after inhalation of a substance or a mixture. ’ 
(g) Section 3.4.1.2 . is replaced by the following:  
‘3.4.1.2 . Skin sensitisation means  an allergic response occurring after skin contact 
with a substance or a mixture. ’ 
 (h) Section 3.4.2.1.3 .1. is replaced by the following:  
‘3.4.2.1.3.1 . Data from appropriate animal studies1 which may be indicative of the potential 
of a substance to cause sensiti sation by inhalation in humans2 may include:  
(a) measurements of Immunoglobulin E (IgE) and other specific immunological 
parameters, for example in mice;  
(b) specific pulmonary responses in guinea pigs.   
17 
 1 At present, recognised and validated  animal models for the testing of respiratory hypersensitivity are not 
available. Under certain circumstances, data from  animal studies may provide valuable information in a weight 
of evidence assessment . 
 
2 The mechanisms by which substances induce symptoms of asthma are not yet fully known. For preventative 
measures, these substances are considered respiratory se nsitisers.  However, if on the basis of the evidence, it 
can be demonstrated that these substances induce symptoms of asthma by irritation only in people with 
bronchial hyper -reactivity, they shall  not be considered as respiratory sensitisers.’  
 
(i) In sec tion 3.4.3.3.2.  , Table 3.4.6 , Note 1  is replaced by the following :  
 
‘Note 1:  
 
This concentration limit for elicitation is used for the application of the special labelling 
requirements of section 2.8 of Annex II to protect already sensitised individuals.  A SDS is required 
for the mixture containing a component at or above this concentration. For sensitising substances 
with a specific concentration limit , the concentration limit for elicitation shall  be set at a tenth of 
the specific concentration limit. ’ 
 
(j) Section 3.5.1.1 . is replaced by the following : 
 
‘3.5.1.1 . Germ cell mutagenicity means  heritable gene mutations, including heritable 
structural and numerical chromosome aberrations in germ cells occurring after 
exposure to a substance or mixture. ’ 
(k) Section 3.5.1.1 . is renumbered as follows:  
‘3.5.1.2 . A mutation means a permanent change in the amount or structure of the genetic 
material in a cell. The term ‘mutation’ applies both to heritable genetic changes 
that may be manifested at the phenotypic level and to the underlying DNA 
modifications when known (including specific base pair changes and 
chromosomal translocations). The term ‘mutagenic’ and ‘mutagen’ will be used 
for agents giving rise to an increased occurrence of mutations in populations of  
cells and/or organisms. ’  
(l) Section 3.5.1.2 . is renumbered as follows:  
‘3.5.1.3 . The more general terms ‘genotoxic’ and ‘genotoxicity’ apply to agents or 
processes which alter the structure, information content, or segregation of DNA, 
including those w hich cause DNA damage by interfering with normal replication 
processes, or which in a non - physiological manner (temporarily) alter its 
replication. Genotoxicity test results are usually taken as indicators for mutagenic 
effects .’ 
 (m) Section 3.5.2.3.5 . is replaced by the following:  
 
‘3.5.2.3.5.  In vivo somatic cell mutagenicity  tests, such as:  
 
- mammalian bone marrow chromosome aberration test;   
- mammalian erythrocyte micronucleus test ’ 
  
(n) Section 3.6 .1.1. is replaced by the following:  
 
‘3.6.1.1 . Carcinogenicity  refers to the induction of cancer or an increase in the incidence of 
cancer occurring after exposure to a substance or mixture. Substances and 
mixtures which have induced benign and malignant tumours in well performed 
experimental studies o n animals are considered also to be presumed or suspected  
18 
 human carcinogens unless there is strong evidence that the mechanism of tumour 
formation is not relevant for  humans.  
Classification of a substance or mixture as posing a carcinogenic hazard is based  
on its in trinsic  properties and does not provide information on the level of the 
human cancer risk with the use of the substance or mixture may represent .’ 
(o) Section 3.7.1.1 . is replaced by the following:  
 
‘3.7.1.1 . Reproductive  toxicity refers to adverse effects on sexual function and fertility in 
adult males and females, as well as developmental toxicity in the offspring, 
occurring after exposure to a substance or mixture. The definitions presented 
below are adapted from those agreed as working de finitions in IPCS/EHC 
Document N°225 , Principles for Evaluating Health Risks to Reproduction 
Associated with Exposure to Chemicals. For classification purposes, the known 
induction of genetically based inheritable effects in the offspring is addressed in 
Germ Cell Mutagenicity  (Section  3.5), since in the present classification system it 
is considered more appropriate to address such effects under the separate hazard 
class of germ cell mutagenicity.  
 In this classification system, reproductive toxicity is s ubdivided into two main 
headings:  
 (a) adverse effects on sexual function and fertility;  
 (b) adverse effects on development of the offspring.  
Some reproductive toxic effects cannot be clearly assigned to either impairment of 
sexual function and fertility or to developmental toxicity. Nonetheless, substances 
and mixtures with these effects shall be classified as with a general hazard 
statement.’   
(p) Section 3.7.2.5.1 . is replaced by the following : 
 
‘3.7.2.5.1 . A number of internationally accepted test methods are available; these include 
methods for developmental toxicity testing (e.g. OECD Test Guideline 414) and 
methods for one or two -generatio n toxicity testing (e. g. OECD Test Guidelines 
415, 416, 443) .’ 
(q) Section 3.8.1.1 . is replaced by the following:  
 
‘3.8.1.1 . Specific target organ toxicity – single exposure means  specific, non -lethal toxic 
effects on target organs occurring after a single exposure to a substance or 
mixture. All significant health effects that can impair function, both reversible and 
irreversible, immediate and/or delayed and not specifically addre ssed in sections  
3.1 to 3.7 and 3.10 are included  (see also section  3.8.1.6). ’ 
 
(r) Section 3.8.3.4.1 . is replaced by the following:  
 
‘3.8.3.4.1 . Where there is no reliable evidence or test data for the specific mixture itself, and 
the bridging principles cannot be used to enable classification, then classification 
of the mixture is based on the classification of the ingredient substances. In this 
case, the mixture shall be classified as a specific target organ toxicant (specific 
organ specified), following  single exposure, when at least one ingredient has been 
classified as a Category 1 or Category 2 specific target organ toxicant (single  
19 
 exposure) and is present at or above the appropriate generic concentration limit as 
mentioned in Table 3.8.3 for  Categor y 1 and 2 respectively.’  
 
(s) In section 3.8.3.4 .  section 3.8.3.4.6 . is added : 
 
‘3.8.3.4.6 . In cases where the additivity approach is used for Category 3 ingredients, the 
“relevant ingredients” of a mixture are those which are present in concentrations 
≥1 % (w/w for solids, liquids, dusts, mists, and vapours and v/v for gases), unless 
there is a reason to suspect that an ingredient present at a concentration <1  % is 
still relevant when classifying the mixture for respiratory tract irritation or 
narcotic ef fects. ’ 
(t) Section 3.9.1.1 . is replaced by the following:  
‘3.9.1.1 . Specific target organ toxicity -repeated exposure means  specific toxic effects on 
target organs occurring after repeated exposure to a substances or mixture. All 
significant health effects that can impair function, reversible and irreversible, 
immediate and/or delayed are included.  However, other specific toxic effects  that 
are specifically addressed in sections 3.1 to 3.8 and 3.10 are not included here .’ 
 (u) Section 3.9.3.4.1 . is replaced by the following :  
 
‘3.9.3.4.1 . Where there is no reliable evidence or test data for the specific  mixture itself, and 
the bridging principles cannot be used to  enable classification, then classification 
of the mixture is based on  the classificatio n of the ingredient substances. In this 
case, the  mixture shall be classified as a specific target organ toxicant  (specific 
organ specified), following repeated exposure when at least one ingredient has 
been classified  as a Category 1 or Category 2 specifi c target organ toxicant  
(repeated exposure) and is  present at or above the appropriate generic 
concentration limit as  laid out in Table 3.9.4 for Category 1 and 2 respectively. ’ 
(v) Section 3.10.1. 3. is replaced by the following:   
 
‘3.10.1. 3. Aspiration hazard means severe acute effects such as chemical pneumonia, 
pulmonary injury or death occurring after aspira tion of a substance or mixture.’  
(w) In section 3.10.3.3 . a new section is added  :  
 
‘3.10.3.3.1 .1. The “relevant ingredients” of a mix ture are those which are present in 
concentrations ≥ 1  %.’ 
(x) Section 3.10.3.3.1 .1. is renumbered and replaced by the following :  
‘3.10.3.3. 1.2.  A mixture is classified as Category 1 when the sum of the concentrations of  
 Category 1 ingredients is ≥10  % and the mixture has a kinematic viscosity 
≤20.5 mm2/s, measured at 40  °C.’ 
 
 (y) Section 3.10.3.3.1.2 . is renumbered and replaced by the following:  
‘3.10.3.3. 1.3.  In the case of a mixture which separates into two or more distinct layers, the 
entire mixtu re is classified as Category 1 if in any distinct layer the sum of the 
concentrations of Category 1 ingredients is ≥  10 %, and it has a kinematic 
viscosity ≤ 20.5  mm2/s, measured at 40  °C.’ 
  
20 
 Part 4 is amended as follows:  
(a) Section 4.1.3.5.5.3.1 . is replaced by the following :  
 
‘4.1.3.5.5.3.1 . First, all components classified as Acute 1 are considered. If the sum of the 
concentrations (in %) of these components multiplied by their corresponding 
M-factors is ≥25 % the whole mixture is classified as Acu te 1.’ 
 
ANNEX II  
 
Annex II to Regulation (EC) No 1272/2008 is amended as follows:  
 
1. Part I is amended as follows:  
 
(a) the following entry is deleted : 
 
‘EUH001 — ‘Explosive when dry’ For explosive substances and mixtures as referred  
to in section 2.1 of Annex  I, placed on the market wetted with water or alcohols or 
diluted with other substances to suppress their explosive properties. ’ 
 
(b)  In section 2.10. the third indent is replaced by the following:  
‘- ≥ one tenth of the specific concentration limit for a substance classified as skin 
sensitiser or respiratory sensitiser  with a specific concentration limit , or’ 
 
ANNEX I II 
 
Annex III to Regulation (EC) No 1272/2008 is amended as follows:  
 
1. Part 1 is amended as follows:  
 
(a) The following Hazard Statements are added  to Table 1.1:  
 
‘H206  Language  2.17, Desensitised explosives , Hazard 
Category 1 
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Fire, blast or projection hazard ; 
increased risk of explosion if 
desensiti sing agent is reduced ’ 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT   
21 
  HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV  
 
H207  Language  2.17, Desensitised explosives , Hazard 
Category 2, 3  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Fire or projection hazard ; increased risk 
of explosion if desensiti sing agent is 
reduced  
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV  
 
H208  Language  2.17, Desensitised explosives , Hazard 
Category 4  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN Fire hazard ; increased risk of  explosion 
if desensiti sing agent is reduced  
 FR   
22 
  GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV  
 
‘H232  Language  2.2 Flammable gases, Hazard Category 
1A, pyrophoric gas  
 BG  
 ES  
 CS  
 DA  
 DE  
 ET  
 EL  
 EN May ignite spontaneously if exposed to 
air’ 
 FR  
 GA  
 HR  
 IT  
 LV  
 LT  
 HU  
 MT  
 NL  
 PL  
 PT  
 RO  
 SK  
 SL  
 FI  
 SV  
 
(b) Table 1.1 is amended as follows:  
 
(i) The top row of the entry concerning H220 is replaced by the following:  
 
‘H220  Language  2.2 – Flammable gases, Hazard 
Category 1A ’ 
 
(ii) The top row of the entry concerning H221 is replaced by the following:   
23 
  
‘H221  Language  2.2 – Flammable gases, Hazard 
Category 1B, 2 ’ 
 
(iii) The top row of the entry concerning H 230 is replaced by the following:  
 
‘H230  Language  2.2 - Flammable gases, Hazard 
Category 1A, chemically unstable gas 
A’ 
 
(iv)  The top row of the entry concerning H231 is replaced by the following:  
 
‘H231  Language  2.2 - Flammable gases, Hazard 
Category 1A, chemically unstable gas 
B’ 
 
(c) The 10th row of the entry concerning H314 is replaced by the following : 
 
 ‘FR Provoque de graves  brûlures de la peau 
et de graves lésions des yeux .’ 
 
 
2. Part 2 is amended as follows:  
 
(a) In Table 2.1 . the entry for EUH 001 is deleted.  
 
ANNEX IV 
 
Annex IV  to Regulation (EC) No 1272/2008 is amended as follows:  
 
(1) The first  introductory  paragraph  of Annex IV is replaced by the following:  
 
‘This Annex  sets out a matrix listing the recommended precautionary statements for each 
hazard class and hazard category by type of precautionary statement. The matrix guides the 
selection of appropriate precautionary statements, and includes elements for all categor ies of 
precautionary action. All specific elements relating to particular hazard classes shall  be used. 
In addition, general precautionary statements not linked to a certain hazard class  or category 
shall  also be used where relevant.  
To provide flexibility  in the application of precautionary phrases, combinations or 
consolidations of precautionary statements are encouraged to save label space and improve 
readability. The matrix and the Tables in Part 1 of this Annex include a number of combined 
precautionar y statements. However, these are only examples and suppliers  may further 
combine and consolidate phrases where this contributes to clarity and comprehensibility of 
label information  in accord ance with Articles 22 and 28(3).  
Notwithstanding Article 22 the p recautionary statements that appear on labels or in safety data 
sheets may incorporate minor textual variations from those set out in this Annex  where these 
variations assist in communicating safety information and the safety advice is not diluted or 
compr omised. These may include spelling variations, synonyms or other equivalent terms 
appropriate to the region where the product is supplied and used. ’ 
  
24 
 (a) Table 6.1 is amended as follows:  
 
(i) The e ntry concerning code  P103 is replaced by the following:  
 
 
 
 
 
 
(b) Table 6.2 is amended as follows:  
 
(i) The entr ies concerning code s P201  and P202 are  replaced by the following : 
 
 
 ‘P103  Read carefully 
and follow all 
instructions  As appropriate   Consumer products – 
omit where P202 is 
used’ 
‘P201  Obtain special 
instructions before 
use. Explosives (section 2.1)  Unstable 
explosive   
Germ cell mutagenicity 
(section 3.5)  1A,1B, 2  
Consumer 
products – 
omit where 
P202 is used ’ Carcinogenicity (section 3.6)  1A,1B, 2  
Reproductive toxicity 
(section 3.7)  1A,1B, 2  
Reproductive toxicity — 
effects on or via lactation 
(section 3.7)  Additional 
category  
P202  Do not handle 
until all safety 
precautions have 
been read and 
understood  Flammable gases  (section 
2.2) A, B 
(chemically 
unstable gases)   
Germ cell mutagenicity 
(section 3.5)  1A,1B, 2   
Carcinogenicity (section 3.6)  1A,1B, 2   
Reproductive toxicity 
(section 3.7)  1A,1B, 2   
Reproductive toxicity, 
effects on or via lactation 
(section 3.7)  Additional 
category   
      
25 
  
(iii) The entry concerning code P212 is inserted :  
 
 
‘P212  Avoid heating under 
confinement or reduction of the 
desensitising agent  
 Desensitised  
explosives 
(section 2.17)  1, 2, 3, 4 ’  
 
(iv) The entry concerning code P222 is replaced by the following:  
 
 
(v) The entry concerning code P230 is replaced by the following:  
 (ii) The entry concerning code P210 is replaced by the following:  
‘P210  Keep away from 
heat, hot surfaces, 
sparks, open 
flames and other 
ignition sources. 
No smoking.  Explosives (section 2.1)  Divisions 1.1, 
1.2, 1.3, 1.4, 
1.5  
Flammable gases (section 
2.2) 1A, 1B, 2  
 Aerosols (section 2.3)  1, 2, 3  
Flammable liquids (section 
2.6 1, 2, 3  
Flammable solids (section 
2.7) 1, 2 
Self-reactive substances and 
mixtures (section 2.8)  Types A, B, C, 
D, E, F  
Pyrophoric liquids (section 
2.9) 1 
Pyrophoric solids (section 
2.10)  1 
Oxidising liquids (section 
2.13)  1, 2, 3   
Oxidising solids (section 
2.14)  1, 2, 3   
Organic peroxides (section 
2.15)  Types A, B, C, 
D, E, F ’  
Desensitised explosives 
(section 2.17)  1, 2, 3, 4 ’  
‘P222  Do not allow contact with air.  Flammable 
gases (section 
2.2) Pyrophoric gas  – if emphasis of 
the hazard 
statement is 
deemed 
necessary. ’ Pyrophoric 
liquids (section 
2.9) 1 
Pyrophoric 
solids (section 
2.10)  1  
26 
  
(vi) The entry concerning code P233 is replaced by the following:  
 
‘P233  Keep container 
tightly closed.  Flammable liquids (section 
2.6) 1, 2, 3  - if the liquid is  
  volatile and may  
  generate an  
  explosive  
  atmosphere  
Pyrophoric liquids (section 
2.9) 1  
Pyrophoric solids (section 
2.10)  1  
Desensitised explosives 
(section 2.17)  1, 2, 3, 4   
Acute toxicity – inhalation 
(section 3.1)  1, 2, 3  - if the chemical is 
volatile and may 
generate a 
hazardous 
atmosphere ’ Specific target organ 
toxicity – single exposure; 
respiratory tract irritation 
(section  3.8) 3 
Specific target organ 
toxicity – single exposure; 
narcotic effects (section 
3.8) 3 
 
(vii) The entry concerning code P280 is replaced by the following:  
 ‘P230  Keep wetted with 
... 
 Explosives (section 2.1)  Divisions 1.1, 
1.2, 1.3, 1.5  Manufacturer/  
supplier to specify 
appropriate 
material  
–  for substances 
and mixtures 
which are wetted, 
diluted, dissolved 
or suspended with 
a phlegmatiser in 
order to suppress 
their explosive 
properties  
Desensitised  explosives 
(section 2.17)  1, 2, 3, 4  Manufacturer/  
supplier to specify 
appropriate 
material ’   
27 
 ‘P280  Wear protective 
gloves/protective 
clothing/eye 
protection/face 
protection/  
hearing 
protection/…  
 Explosives (section 2.1)  Unstable 
explosive and 
divisions 1.1, 
1.2, 1.3, 1.4, 1.5  Manufacturer/  
supplier to specify 
the appropriate type 
of personal 
protective 
equipment.  
 Flammable gases (section 
2.2) Pyrophoric gas  
Flammable liquids (section 
2.6) 1, 2, 3  
Flammable solids (section 
2.7) 1, 2 
Self-reactive substances 
and mixtures (section 2.8)  Types A, B, C, 
D, E, F  
Pyrophoric liquids (section 
2.9) 1 
Pyrophoric solids (section 
2.10)  1 
Self-heating substances and 
mixtures (section 2.11)  1, 2 
Substances and mixtures 
which, in contact with 
water, emit flammable 
gases (section 2.12)  1, 2, 3  
  Oxidizing liquids (section 
2.13)  1, 2, 3  
Oxidizing solids (section 
2.14)  1, 2, 3  
Organic peroxides (section 
2.15)  Types A, B, C, 
D, E, F  
Desensitised explosives 
(section 2.17)  1, 2, 3, 4  
Acute toxicity – dermal 
(section 3.1)  1, 2, 3, 4  – Specify protective 
gloves/clothing.  
Manufacturer/  
supplier may 
further specify type 
of equipment where 
appropriate.  
Skin corrosion (section 3.2)  1A, 1B, 1C  – Specify protective 
gloves/clothing and 
eye/face protection.  
Manufacturer/  
supplier may 
further specify type 
of equipment where 
appropriate.  
Skin irritation (section 3.2)  2 – Specify protective  
28 
  
(b) Table 6.3 is amended as follows:  
 
(i) The entries concerning code P301 and P302 are replaced by the following:  
 
‘P301  IF 
SWALLOWED:  Acute toxicity – oral 
(section 3.1)  1, 2, 3, 4   
Skin corrosion (section 
3.2) 1, 1A, 1B, 1C  
Aspiration Hazard 
(section 3.10)  1 
P302  IF ON SKIN:  Pyrophoric liquids 
(section 2.9)  1  
Pyrophoric solids 
(section 2.10)  1 
Substances and mixtures 
which, in contact with 
water, emit flammable 
gases (section 2.12)  1, 2 
Acute toxicity – dermal 
(section 3.1)  1, 2, 3, 4  
Skin irritation (section 
3.2) 2 
Skin sensitisation 
(section 3.4)  1, 1A, 1B ’ 
 
(ii) The entry concerning code P332 is replaced by the following:  
 
‘P332  If skin irritation 
occurs:  Skin irritation 
(section 3.2)  2 may be omitted 
if P333 is 
given on the Skin sensitization (section 
3.4) 1, 1A, 1B  gloves.  
Manufacturer/  
supplier may 
further specify type 
of equipment where 
appropriate.  
Serious eye damage 
(section 3.3)  1 – Specify eye/face 
protection.  
Manufacturer/  
supplier may 
further specify type 
of equipment where 
appropriate.  Eye irritation (chapter 3.3)  2 
Germ cell mutagenicity 
(chapter 3.5)  1A, 1B, 2  Manufacturer/  
supplier to specify 
the appropriate type 
of personal 
protective 
equipment. ’ 
 
   Carcinogenicity (section 
3.6) 1A, 1B, 2  
  Reproductive toxicity 
(section 3.7)  1A, 1B, 2   
29 
 label. ’ 
 
(iii) The entry  concerning codes P370 and 371 are replaced by the following:  
‘P370  In case of fire:  Explosives (section 2.1)  Unstable 
explosives 
and 
divisions 
1.1, 1.2, 1.3, 
1.4, 1.5  
 Oxidising gases 
(section 2.4)  1 
Flammable liquids 
(section 2.6)  1, 2, 3 
Flammable solids 
(section 2.7)  1, 2 
Self-reactive substances 
and mixtures (section 
2.8) Types A, B, 
C, D, E, F  
Pyrophoric liquids 
(section 2.9)  1 
Pyrophoric solids 
(section 2.10)  1 
Substances and 
mixtures which, in 
contact with water,  emit 
flammable gases 
(section  2.12)  1, 2, 3  
Oxidising liquids 
(section 2.13)  1, 2, 3  
Oxidising solids 
(section 2.14)  1, 2, 3  
Organic Peroxides 
(section 2.15)  Types A, B, 
C, D, E, F  
Desensitised explosives 
(section 2.17)  1, 2, 3 ’  
‘P371  In case of major 
fire and large 
quantities:  Oxidising liquids 
(section 2.13)  1  
Oxidising solids 
(section 2.14)  1  
Desensitised explosives 
(section 2.17)  4’  
 
(iv) The entry concerning code P375 is replaced by the following:  
'P375  Fight fire remotely 
due to the risk of 
explosion.  Explosives (section 2.1)  Division 
1.4 - for explosives of 
division 1.4 
(compatibility 
group S) in 
transport 
packaging. ’  
30 
 Self-reactive substances 
and mixtures (section 
2.8) Type B  
 Oxidising liquids 
(section 2.13)  1 
Oxidising solids (section 
2.14)  1 
Organic peroxides 
(section 2.15)  Type B  
  Desensitised explosives 
(section 2.17)  1, 2, 3, 4’   
 
(v) The entry concerning code P377 is replaced by the following:  
 
‘P377  Leaking gas fire: 
Do not 
extinguish, unless 
leak can be 
stopped safely.  Flammable gases 
(section 2.2)  1A, 1B, 2 ’  
 
(vi) The entry concerning code P380 is replaced by the following:  
‘P380  Evacuate area.  Explosives (section 2.1)  
 Unstable 
explosives,  
Divisions 
1.1, 1.2, 
1.3, 1.4, 1.5   
Self-reactive substances 
and mixtures  
(section 2.8)  Types A, B   
Oxidising liquids 
(section 2.13)  1  
Oxidising solids (section 
2.14)  1  
Organic peroxides 
(section 2.15)  Types A, 
B’  
  Desensitised explosives 
(section 2.17)  1, 2, 3, 4 ’  
 
(vii) The entry concerning code P381 is replaced by the following:  
 
‘P381  In case of leakage 
eliminate all 
ignition sources  Flammable gases 
(section 2.2)  1A, 1B, 2 ’  
 
(viii) The entry concerning code P301 + P312 is replaced by the following:  
  
31 
 ‘P301 
+ P312  IF 
SWALLOWED: 
Call a POISON 
CENTER/doctor/
…/if you feel 
unwell  Acute toxicity – oral 
(section 3.1)  4 …Manufacturer/  
supplier to 
specify the 
appropriate 
source of 
emergency 
medical advice ’ 
 
(ix) The entry concerning code P302 + P352 is replaced by the following:  
 
‘P302 
+ P352  IF ON SKIN: 
Wash with plenty 
of water/….  Acute toxicity – dermal 
(section 3.1)  1, 2, 3, 4  …Manufacturer/  
supplier may 
specify a 
cleansing agent if 
appropriate, or 
may recommend 
an alternative 
agent in 
exceptional cases 
if water is clearly 
inappropriate. ’ Skin irritation (section 
3.2) 2 
Skin sensitisation 
(section 3.4)  1, 1A, 1B  
 
 
(x) The entries concerning codes P370 + P380 + P375 and P371 + P380 + P375 are 
replaced by the following:  
‘P370 + 
P380 + 
P375  In case of fire: 
Evacuate area. 
Fight fire remotely 
due to the risk of 
explosion.  Explosives (section 2.1)  Division 
1.4 - for explosives of 
division 1.4 
(compatibility 
group S) in 
transport 
packaging ’ 
Desensitised explosives 
(section 2.17)  1, 2, 3  
 
P371 + 
P380 + 
P375  In case of major 
fire and large 
quantities: 
Evacuate area. 
Fight fire remotely 
due to the risk of 
explosion.  Oxidising liquids 
(section 2.13)  1 
 Oxidising solids (section 
2.14)  1 
Desensitised explosives 
(section 2.17)  4  
 
 
(d) Table 6.4 is amended as follows:  
 
(i) The entry concerning code P401 is replaced by the following:  
  
32 
 'P401  Store in accordance 
with …  Explosives (section 2.1)  Unstable 
explosives 
and 
Divisions 
1.1, 1.2, 
1.3, 1.4, 1.5  … Manufacturer/  
supplier to 
specify 
local/regional/ 
national/  
      international 
regulations as 
applicable.  ’ Desensitised explosives 
(section 2.17)  1, 2, 3, 4  
 
(ii) The entry concerning code P403 is replaced by the following:  
‘P403  Store in a well -
ventilated place.  Flammable gases 
(section  2.2) 1A, 1B, 2   
Oxidising gases (section 
2.4) 1 
Gases under pressure 
(section 2.5)  Compressed 
gas 
Liquefied 
gas 
Refrigerated 
liquefied 
gas 
Dissolved 
gas 
Flammable liquids 
(section 2.6)  1, 2, 3  - for flammable 
liquids 
Category 1 and 
other 
flammable 
liquids that are 
volatile and 
may generate 
an explosive 
atmosphere.  
Self-reactive substances 
and mixtures (section 
2.8) Types A, B, 
C, D, E, F  
 - except  for 
temperature 
controlled self -
reactive 
substances and 
mixtures or 
organic 
peroxides 
because 
condensation 
and consequent 
freezing may 
take place.  Organic peroxides 
(section 2.15)  
Acute toxicity – 
inhalation (section 3.1)  1, 2, 3  – if the substance 
or mixture is  
33 
 Specific target organ 
toxicity – single 
exposure; respiratory 
tract irritation 
(section  3.8) 3 volatile and 
may generate a 
hazardous 
atmosphere. ’ 
 Specific target organ 
toxicity – single 
exposure; narcotic 
effects (section 3.8)  3 
 
(e) Table 6.5 is amended as follows:  
 
(i) The entry concerning code P501 is replaced by the following:  
‘P501  Dispose of 
contents/container 
to ... Flammable liquids 
(section 2.6)  1, 2, 3  ……in 
accordance with 
local/regional/  
national/  
international 
regulation (to be 
specified).  
Manufacturer/  
supplier to specify 
whether disposal 
requirements 
apply to contents, 
container or both .’  Self-reactive substances 
and mixtures (section 
2.8) Types  
A, B, C, D, 
E, F 
Substances and mixtures 
which, in contact with 
water, emit flammable 
gases  (section 2.12)  1, 2, 3  
Oxidising  liquids 
(section 2.13)  1, 2, 3  
Oxidising solids (section 
2.14)  1, 2, 3  
Organic peroxides 
(section 2.15)  Types  
A, B, C, D, 
E, F 
Desensitised explosives 
(section 2.17)  1, 2, 3, 4  
Acute toxicity – oral 
(section 3.1)  1, 2, 3, 4  
Acute toxicity – dermal 
(section 3.1)  1, 2, 3, 4  
Acute toxicity – 
inhalation (section 3.1)  1, 2, 3  
Skin corrosion (section 
3.2) 1, 1A, 1B, 
1C 
  Respiratory sensitisation 
(section 3.4)  1, 1A, 1B  
Skin sensitisation 
(section 3.4)  1, 1A, 1B  
Germ cell mutagenicity 
(section 3.5)  1A, 1B, 2  
Carcinogenicity (section 
3.6) 1A, 1B, 2  
Reproductive toxicity 1A, 1B, 2   
34 
 (section 3.7)  
Specific target organ 
toxicity – single 
exposure (section 3.8)  1, 2 
Specific target organ 
toxicity – single 
exposure; respiratory 
tract irritation 
(section  3.8) 3 
Specific target organ 
toxicity – single 
exposure; narcotic effects 
(section 3.8)  3 
Specific target organ 
toxicity – repeated 
exposure (section 3.9)  1, 2 
Aspiration hazard 
(section 3.10)  1 
Hazardous to the aquatic 
environment – acute 
aquatic hazard (section 
4.1)  1 
Hazardous to the aquatic 
environment – chronic 
aquatic hazard (section 
4.1) 1, 2, 3, 4  
 
 
(ii)  The following new entry is inserted after code P502:  
 
‘P503  Refer to 
manufacturer/ 
supplier/… for 
information on 
disposal/recovery/ 
recycling  Explosives (chapter 
2.1) Unstable 
explosives 
and 
Divisions 
1.1, 1.2, 
1.3, 1.4, 
1.5 … Manufacturer/  
supplier to 
specify 
appropriate 
source of 
information in 
accordance with 
local/regional/  
national/  
international 
regulations as 
applicable .’ 
 
 
(f ) Table 1.2. is amended as follows:  
 
(i) The following new entry is inserted : 
 
‘P212  Avoid heating under confinement or reduction of the desensitising agent  
  
35 
 ANNEX V  
 
Annex V  to Regulation (EC) No 1272/2008 is amended as follows:  
 
1. Part 1, section 1.2 is amended as follows:  
 
a) ‘In column 2 , the sentence “ Flammable gases, hazard category 1” is replaced by 
‘“Flammable gases, hazard categor ies 1A, 1B ”.’ 
b) In column 2, the sentence  ‘ “Section 2.17 Desensitised explosives, hazard categories 1, 
2, 3, 4” is added after the last entry .’ 
 
ANNEX VI  
 
1. Part 1 of Annex VI to Regulation (EC) No 1272/2008 is amended as follows:  
 
a) In Table 1. 1 the row concerning F lammable gases is replaced by the following:  
 
‘Flammable gases  Flam. Gas 1A  
Flam. Gas 1B  
Flam. Gas 2  
Pyr. Gas  
Chem. Unst. Gas A  
Chem. Unst. Gas B ‘ 
 
b) In Table 1.1 t he following  row is added aft er the row  “Substance  or mixture corrosive  
to metals ”: 
 
‘Desensitised explosives  Desen. Expl. 1  
Desen. Expl. 2  
Desen. Expl. 3  
Desen. Expl. 4 ’