1 
 EN 
ANNEX 
Annex VI to Regulation (EC) No  1272/2008 is amended as follows: 
(1) in Part 1, the heading of point  1.1.1.4 is replaced by the following: 
'Chemical name '; 
(2) in Part 3, Table 3.1 is amended as follows: 
(a) the title of the second column is re placed by the following: 'Chemical name'; 
(b) the title of the penultimate  column is replaced by th e following: 'Specific Conc. Limits, M-factors and ATEs*' 
'* ATEs for oral and dermal exposure routes are expressed in mg/kg bw, wh ich stands for milligram per kilogram 
bodyweight.' 
(c) the entry corresponding to i ndex number 607-414-00-6 is deleted;  
(d) the entries corresponding to index numbers 006-044-00-7, 015-101-00-5, 016-096-00-2, 017-011-00-1, 025-002-00-9, 603-
180-00-4, 604-014-00-3, 604-016-00-4, 604-090-00-8, 605-003- 00-6, 606-047-009, 607-096-00-9,  607-103-00-5, 607-113-
00-X, 607-373-00-4, 613-167-00-5, 613- 205-00-0 and 614-001-00-4  are replaced by the following entries respectively:  
 
Index No Chemical name EC No CAS No Classification Labelling Specific 
Conc. Limits, 
M- 
factors and ATEs Note
s 
Hazard Class 
and Category 
Code(s) Hazard 
statement 
Code(s) Pictogram
, Signal 
Word  
Code(s) Hazard 
statement 
Code(s) Suppl. 
Hazard 
statement 
Code(s) 2 
 Index No Chemical name EC No CAS No Classification Labelling Specific 
Conc. Limits, 
M- factors and 
ATEs Note
s 
Hazard Class 
and Category 
Code(s) Hazard 
statement 
Code(s) Pictogram
, Signal 
Word  
Code(s) Hazard 
statement 
Code(s) Suppl. 
Hazard 
statement 
Code(s) 
‘006-044-00-7 
 isoproturon (ISO);  
3-(4-isopropylphenyl)-1,1-dimethylurea 251-835-4 34123-59-6 Carc. 2 
STOT RE 2 
Aquatic Acute 1 
Aquatic Chronic 1  H351 
H373 (blood) 
H400 
H410 GHS08 
GHS09 
Wng H351 
H373 (blood) 
H410   
 
M=10 
M=10’  
‘015-101-
00-5 phosmet (ISO);  
S-[(1,3-dioxo-1,3-dihydro-2 H-isoindol-2-
yl)methyl] O,O-dimethyl phosphorodithioate; 
O,O-dimethyl- S-phthalimidomethyl 
phosphorodithioate 
 211-987-4 732-11-6 
 Repr. 2 
Acute Tox. 4 
Acute Tox. 3  STOT SE 1 
Aquatic Acute 1 
Aquatic Chronic 1  H361f 
H332 
H301 H370 
(nervous 
system) H400 
H410 
 GHS08 
GHS06 
GHS09 Dgr 
 H361f 
H332 
H301 H370 
(nervous 
system) H410 
   
 
  
 
 M=100 
M=100’  
‘016-096-
00-2 
 thifensulfuron-methyl (ISO);  
methyl 3-(4-methoxy-6-methyl-1,3,5-triazin-2-
ylcarbamoylsulfamoyl)thiophene-2-carboxylate - 79277-27-3 Aquatic Acute 1 
Aquatic Chronic 1  
 H400 
H410 
 GHS09 
Wng 
 H410  M=100 
M=100’  
‘017-011-
00-1  sodium hypochlorite, solution ... % Cl active 231-668-3 7681-52-9  Skin Corr. 1B 
Eye Dam. 1 Aquatic Acute 1 
Aquatic Chronic 1 H314 
H318 H400 
H410 GHS05 
GHS09 Dgr H314 
H410 EUH031  
M=10 M=1  B’ 
‘025-002-
00-9 
 potassium permanganate 231-760-3 7722-64-7 Ox. Sol. 2  
Repr. 2 
Acute Tox. 4 * 
Aquatic Acute 1 Aquatic Chronic 1 H272 
H361d 
H302  
H400 H410 GHS03 
GHS08 
GHS07 
GHS09  Dgr H272 
H361d 
H302  
H410'     
‘603-180-
00-4 colecalciferol;  
cholecalciferol;  
vitamin D3 200-673-2 67-97-0 Acute Tox. 2 
Acute Tox. 2 
Acute Tox. 2  STOT RE 1  H330 
H310 
H300 H372 
 GHS06 
GHS08 
Dgr H330 
H310 
H300 H372 
  inhalation:  
ATE = 0,05 
mg/L (dusts or mists) 
dermal:  
ATE = 50 mg/kg bw?  
oral:  
ATE = 35 mg/kg bw 
STOT RE 1;  3 
 Index No Chemical name EC No CAS No Classification Labelling Specific 
Conc. Limits, 
M- factors and 
ATEs Note
s 
Hazard Class 
and Category 
Code(s) Hazard 
statement 
Code(s) Pictogram
, Signal 
Word  
Code(s) Hazard 
statement 
Code(s) Suppl. 
Hazard 
statement 
Code(s) 
H372: C ≥ 3 
%  
STOT RE 2; 
H373: 0,3 % ≤ C < 3 %’ 
 
‘604-014-00-3 chlorocresol;  
4-chloro-m-cresol;  
4-chloro-3-methylphenol 200-431-6 59-50-7 Acute Tox. 4 
Skin Corr. 1C 
Eye Dam. 1 STOT SE 3 Skin Sens. 1B 
Aquatic Acute 1 
Aquatic Chronic 3  H302 
H314 
H318 H335 H317 
H400 
H412  GHS07 
GHS05 
GHS09 Dgr H302 
H314 
H335 H317 H410 
   
 
   
M=1’  
‘604-016-
00-4 
 1,2-dihydroxybenzene;  
pyrocatechol 204-427-5 120-80-9 Carc. 1 Β
Muta. 2 
Acute Tox. 3 
Acute Tox. 3   
Skin Irrit. 2 
Eye Irrit. 2 
 H350
H341 
H311 
H301   
H315 
H319 
 GHS08 
GHS06 
Dgr 
 H350
H341 
H311 
H301   
H315 
H319 
  oral:  
ATE = 300 
mg/kg bw 
dermal:  ATE = 600 
mg/kg bw’  
‘604-090-
00-8  4-tert-butylphenol 202-679-0 98-54-4 Repr. 2 
Skin Irrit. 2 Eye Dam. 1 
Aquatic Chronic 1 H361f  
H315  H318  
H410 GHS08 
GHS05 GHS09 
Dgr H361f  
H315  H318 
H410 
   
  
M=1’  
‘605-003-
00-6 
 acetaldehyde;  
ethanal 200-836-8 75-07-0 Flam. Liq. 1 
Carc. 1B 
Muta. 2 
STOT SE 3 Eye Irrit. 2 H224 
H350 
H341 
H335 H319 GHS02 
GHS08 
GHS07 
Dgr H224 
H350 
H341 
H335 H319’    
‘606-047-
00-9 
 2-benzyl-2-dimethylamino-4'-
morpholinobutyrophenone 404-360-3 119313-12-1 Repr. 1B 
Aquatic Acute 1 
Aquatic Chronic 1 H360D 
H400 
H410 GHS08 
GHS09 
Dgr H360D 
H410’    4 
 Index No Chemical name EC No CAS No Classification Labelling Specific 
Conc. Limits, 
M- factors and 
ATEs Note
s 
Hazard Class 
and Category 
Code(s) Hazard 
statement 
Code(s) Pictogram
, Signal 
Word  
Code(s) Hazard 
statement 
Code(s) Suppl. 
Hazard 
statement 
Code(s) 
‘607-096-00-9 maleic anhydride 203-571-6 108-31-6 Acute Tox. 4 
STOT RE 1 
Skin Corr. 1B 
Eye Dam. 1 Resp. Sens. 1 
Skin Sens. 1A 
 H302 
H372 
(respiratory 
system) (inhalation) 
H314 
H318 H334 H317  GHS07 
GHS08 
GHS05 
Dgr 
 H302 
H372 
(respiratory 
system) (inhalation) 
H314 
H334 H317  EUH071 
 Skin Sens. 
1A; H317: C 
≥  0,001%’ 
     
‘607-103-
00-5 succinic anhydride 203-570-0 108-30-5 Acute Tox. 4 
Skin Corr. 1 
Eye Dam. 1 
Resp. Sens. 1 Skin Sens. 1 
 H302 
H314 
H318 
H334 H317 
 GHS07 
GHS05 
GHS08 
Dgr  H302 
H314 
H334 
H317  EUH071’     
‘607-113-
00-X 
 isobutyl methacrylate 202-613-0 97-86-9 Flam. Liq. 3 
STOT SE 3 
Skin Irrit. 2 Skin Sens. 1B H226 
H335 
H315 H317 GHS02 
GHS07 
Wng H226 
H335 
H315 H317    D’ 
‘607-373-
00-4  quizalofop-P-tefuryl (ISO); (+/-) 
tetrahydrofurfuryl (R)-2-[4-(6-chloroquinoxalin-2-
yloxy)phenyloxy]propionate 414-200-4 200509-41-7 Carc. 2 
Repr. 2 Acute Tox. 4  
STOT RE 2 
Aquatic Acute 1 Aquatic Chronic 1 H351 
H361fd H302 
H373 
H400 H410 
 GHS08 
GHS07 GHS09 
Wng H351 
H361fd H302 
H373 
H410    
  
 
M=1 M=1’  
‘613-167-
00-5 reaction mass of 5-chloro-2-methyl-2 H-
isothiazol-3-one and 2-methyl-2 H-isothiazol-3-
one (3:1) - 55965-84-9 Acute Tox. 2 
Acute Tox. 2 
Acute Tox. 3 Skin Corr. 1C 
Eye Dam. 1 
Skin Sens. 1A Aquatic Acute 1 
Aquatic Chronic 1 
 H330 
H310 
H301 H314 
H318 
H317 H400 
H410 GHS06 
GHS05 
GHS09 Dgr H330 
H310 
H301 H314 
H317 
H410  EUH071 
 Skin Corr. 
1C; H314 : C 
≥ 0,6%  
Skin Irrit. 2; 
H315: 0,06% 
≤ C < 0,6% 
Eye Dam. 1 ; 
H318 : C ≥ 
0,6% Eye Irrit. 2; 
H319: 0,06% 
≤ C < 0,6%  
Skin Sens. 1A; H317: C 
≥ 0,0015% B’ 5 
 Index No Chemical name EC No CAS No Classification Labelling Specific 
Conc. Limits, 
M- factors and 
ATEs Note
s 
Hazard Class 
and Category 
Code(s) Hazard 
statement 
Code(s) Pictogram
, Signal 
Word  
Code(s) Hazard 
statement 
Code(s) Suppl. 
Hazard 
statement 
Code(s) 
M=100 M=100 
‘613-205-
00-0 
 propiconazole (ISO); (2 RS,4RS;2RS,4SR)-1-
{[2-(2,4-dichlorophenyl)-4-propyl-1,3-
dioxolan-2-yl]methyl}-1 H-1,2,4-triazole 262-104-4 60207-90-1 Repr. 1B 
Acute Tox. 4 
Skin Sens. 1  Aquatic Acute 1 
Aquatic Chronic 1 H360D 
H302 
H317 H400 
H410 GHS08 
GHS07 
GHS09 Dgr 
 H360D 
H302 
H317 H410    
 
 M=1 
M=1’  
‘614-001-
00-4 nicotine (ISO);  
3-[(2S)-1-methylpyrro lidin-2-yl]pyridine 200-193-3 54-11-5 Acute Tox. 2 
Acute Tox. 2  Acute Tox. 2  
Aquatic Chronic 2 H330 
H310 H300 
H411 GHS06 
GHS09 Dgr H330 
H310 H300 
H411  inhalation:  
ATE = 0.19 mg/L (dusts 
or mists) 
dermal:  ATE = 70 
mg/kg bw’ 
oral:  ATE= 5 mg/kg bw’  
 6 
  
 (e) the following entries are inserted in the appropriate pla ces, following the order of the entries set out in Table 3.1: 
 
Index No Chemical name EC No CAS No Classification Labelling Specific 
Conc. 
Limits, M- factors and 
ATEs Notes 
Hazard Class 
and Category 
Code(s) Hazard 
statement 
Code(s) Pictogram
, Signal 
Word  
Code(s) Hazard 
statement 
Code(s) Suppl. 
Hazard 
statement 
Code(s) 
‘604-094-00-X 
 isoeugenol; [1]  
(E)-2-methoxy-4-(prop-1-enyl)phenol; [2]  
(Z)-2-methoxy-4-(prop-1-enyl)phenol [3] 202-590-7 [1]  
227-678-2 [2]  
227-633-7 [3] 97-54-1 [1]  
5932-68-3 [2] 
5912-86-7 [3] Skin Sens. 1A H317 GHS07 
Wng H317  Skin Sens. 
1A; H317: C 
≥ 0,01%’  
‘607-724-
00-1 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl 
(1R,3R)-2,2-dimethyl-3-[(1 Z)-prop-1-en-1-
yl]cyclopropanecarboxylate; epsilon-metofluthrin - 240494-71-7 Acute Tox. 4 
Acute Tox. 3 
STOT SE  1 STOT RE 2 
Aquatic Acute 1 
Aquatic Chronic 1 H332 
H301 
H370 (nervous 
system) 
H373  H400 
H410 GHS06 
GHS08 
GHS09 Dgr H332 
H301 
H370 (nervous 
system) 
H373  H410   
 
  
 
 M=100 
M=100’  
‘607-725-
00-7 isopropyl (2 E,4E,7S)-11-methoxy-3,7,11-
trimethyldodeca-2,4-dienoate; S-methoprene - 65733-16-6 Aquatic Acute 1 
Aquatic Chronic 1 H400 
H410 GHS09 
Wng H410  M=1 
M=1’  
‘607-726-
00-2 pinoxaden (ISO);  
8-(2,6-diethyl-4-methylphenyl)-7-oxo-1,2,4,5-tetrahydro-7 H-pyrazolo[1,2-
d][1,4,5]oxadiazepin-9-yl 2,2-
dimethylpropanoate - 243973-20-8 Repr. 2 
Acute Tox. 4 Acute Tox. 4 Eye Irrit. 2 
STOT SE 3 
Skin Sens. 1A Aquatic Acute 1 
Aquatic Chronic 3 
 H361d 
H332 H302 H319 
H335   
H317 H400 
H412 
 GHS08 
GHS07 GHS09 Wng  
 H361d 
H332 H302 H319 
H335   
H317 H410 
  inhalation:  
ATE = 4,63 mg/L (dusts or mists) 
oral: ATE = 
500 mg/kg M=1’  7 
 Index No Chemical name EC No CAS No Classification Labelling Specific 
Conc. 
Limits, M- factors and 
ATEs Notes 
Hazard Class 
and Category 
Code(s) Hazard 
statement 
Code(s) Pictogram
, Signal 
Word  
Code(s) Hazard 
statement 
Code(s) Suppl. 
Hazard 
statement 
Code(s) 
‘607-727-00-8 tetramethrin (ISO);  
(1,3-dioxo-1,3,4,5,6,7-hexahydro-2 H-isoindol-
2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-
en-1-yl)cyclopropanecarboxylate 231-711-6 7696-12-0 Carc. 2 
Acute Tox. 4 
STOT SE 2 
Aquatic Acute 1 Aquatic Chronic 1 H351 
H302 
H371 
(nervous system) 
(inhalation) 
H400 H410 GHS08 
GHS07 
GHS09 
Wng H351 
H302 
H371 
(nervous system) 
(inhalation) 
H410   
 
 
  
 
M=100 M=100’  
‘607-728-
00-3  (1,3,4,5,6,7-hexahydro-1,3-dioxo- 2H-isoindol-
2-yl)methyl (1 R-trans )-2,2-dimethyl-3-(2-
methylprop-1-enyl)cyc lopropanecarboxylate 214-619-0 1166-46-7 Carc. 2 
Acute Tox. 4 STOT SE 2 
Aquatic Acute 1 
Aquatic Chronic 1 H351 
H302 H371 
(nervous 
system) (inhalation) 
H400 
H410 GHS08 
GHS07 GHS09 
Wng H351 
H302 H371 
(nervous 
system) (inhalation) 
H410   
  
 
  
M=100 
M=100’  
‘607-729-
00-9 mesosulfuron-methyl (ISO);  
methyl 2-[(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]- α-
(methanesulfonamido)- p-toluate; - 208465-21-8 Aquatic Acute 1 
Aquatic Chronic 1 H400 
H410 GHS09 
Wng H410  M=100 
M=100'  
‘607-730-
00-4 spirodiclofen (ISO);  
3-(2,4-dichlorophenyl)-2-oxo-1-
oxaspiro[4.5]dec-3-en-4-yl 2,2-
dimethylbutyrate - 148477-71-8 Carc. 1B 
Repr. 2 
STOT RE 2 
Skin Sens. 1B Aquatic Chronic 1 H350 
H361f 
H373 
H317 H410 GHS08 
GHS07 
GHS09 
Dgr H350 
H361f 
H373 
H317 H410   
 
 
 M=10’  
‘607-731-
00-X sodium methyl [(4-
aminophenyl)sulphonyl]carbamate; sodium 
methyl ( EZ)-sulfanilylcarboni midate; asulam-
sodium 218-953-8 2302-17-2 Skin Sens. 1 
Aquatic Acute 1 
Aquatic Chronic 1 H317 
H400 
H410 GHS07 
GHS09 
Wng H317 
H410  
  
M=1 
M=1’  
‘607-732-
00-5 salicylic acid 200-712-3 69-72-7 Repr. 2 
Acute Tox. 4 Eye Dam. 1 H361d 
H302 H318 GHS08 
GHS07 GHS05 
Dgr H361d 
H302 H318'     8 
 Index No Chemical name EC No CAS No Classification Labelling Specific 
Conc. 
Limits, M- factors and 
ATEs Notes 
Hazard Class 
and Category 
Code(s) Hazard 
statement 
Code(s) Pictogram
, Signal 
Word  
Code(s) Hazard 
statement 
Code(s) Suppl. 
Hazard 
statement 
Code(s) 
‘608-068-00-9 flutianil (ISO);  
(2Z)-{[2-fluoro-5-
(trifluoromethyl)phenyl]thio}[3-(2-
methoxyphenyl)-1,3-thiazolidin-2-ylidene]acetonitrile - 958647-10-4 Aquatic Chronic 1 H410 GHS09 
Wng H410  M=100’  
‘612-293-
00-8 reaction mass of 1-[2-(2-
aminobutoxy)ethoxy]but-2-ylamine and 1-
({[2-(2-aminobutoxy)ethoxy]methyl}propoxy)but-2-
ylamine 447-920-2 - Repr. 2 
Acute Tox. 4 
Skin Corr. 1B Eye Dam. 1 
 H361f  
H302 
H314 H318 
 GHS08 
GHS07 
GHS05 Dgr H361f  
H302 
H314  EUH071'   
  
‘613-326-
00-9  2-methylisothiazol-3(2 H)-one  220-239-6 2682-20-4 Acute Tox. 2 
Acute Tox. 3 Acute Tox. 3  
Skin Corr. 1B 
Eye Dam. 1 Skin Sens. 1A 
Aquatic Acute 1 
Aquatic Chronic 1 H330 
H311 H301 
H314 
H318 H317 
H400 
H410 GHS05 
GHS06 GHS09 
Dgr H330 
H311 H301 
H314 
H317 H410 EUH071 
 Skin Sens. 
1A; H317: C ≥ 0,0015% 
 
 M=10 
M=1’  
‘613-327-
00-4 
 pyroxsulam (ISO);  
N-(5,7-dimethoxy[1,2,4]triazolo[1,5-
a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide - 422556-08-9 Skin Sens. 1 
Aquatic Acute 1 
Aquatic Chronic 1 H317 
H400 
H410 GHS07 
GHS09 
Wng H317 
H410   
M=100 
M=100’  
‘613-328-
00-X 1-vinylimidazole 214-012-0 1072-63-5 Repr. 1B H360D GHS08 
Dgr  
H360D  Repr. 1B; 
H360D: C ≥ 
0,03% ’ 
  
‘616-224-
00-2 
 amisulbrom (ISO);  
3-(3-bromo-6-fluoro-2-methylindol-1-
ylsulfonyl)- N,N-dimethyl-1 H-1,2,4-triazole-1-
sulfonamide - 348635-87-0 Carc. 2 
Eye Irrit. 2 
Aquatic Acute 1 
Aquatic Chronic 1 H351 
H319 
H400 
H410 GHS08 
GHS07 
GHS09 
Wng H351 
H319 
H410   
 
M=10 
M=10’