COMMI SSION IMPLEMENTING REGUL ATION (EU) 2018/243 
of 15 Febr uary 2018 
concer ning the author isation of 3-hydro xybuta n-2-one, pentan-2,3-dione, 3,5-dimethyl cyclopen ­
tan-1,2-dione, hexan-3 ,4-dione, sec-butan-3-onyl acet ate, 2,6,6-tr imethylcy clohex-2-en-1,4-dione 
and 3-methylnona-2-,4-dione as feed additiv es for all animal species 
(Text with EEA relevance) 
THE EUR OPEAN COMMISSION, 
Having regar d to the Treaty on the Functioning of the European Union, 
Having regar d to Regulation (EC) No 1831/2003 of the European Parliament and of the Council of 22 September 2003 
on additives for use in animal nutr ition (1), and in particular Article 9(2) thereof, 
Whereas: 
(1)  Regulation (EC) No 1831/2003 provi des for the author isation of additives for use in animal nutr ition and for the 
grounds and procedures for granting such author isation. Article 10 of that Regulation provid es for the re- 
evaluation of additives author ised pursuant to Council Directive 70/524/EEC (2). 
(2)  The substances 3-hydro xybutan-2-one, pentan-2,3-dione, 3,5-dimethyl cyclopentan-1,2-dione, hexan-3,4-dione, 
sec-butan-3-ony l acetat e, 2,6,6-tr imethyl cyclohex-2-en-1,4-dione and 3-methylnon a-2-,4-dione (‘substances 
concer ned’) were author ised without a time limit by Directive 70/524/EEC as feed additives for all animal 
species. Those substances were subsequently entered in the Register of feed additives as existing products, in 
accordance with Article 10(1) of Regulation (EC) No 1831/2003. 
(3)  In accordance with Article 10(2) of Regulation (EC) No 1831/2003 in conjunction with Article 7 thereof, an 
application was submitted for the re-evaluation of the substances concer ned as feed additives for all animal 
species. The applicant request ed that those additives be classified in the additive categor y ‘sensor y additives ’. That 
application was accompan ied by the particulars and documents required under Article 7(3) of Regulation (EC) 
No 1831/2003. 
(4)  The European Food Safety Auth ority (‘the Author ity’) concluded in its opinion of 19 October 2016 (3) that, 
under the proposed conditions of use the substances concer ned do not have adverse effects on animal health, 
human health or the environment. The Auth ority has concluded that, since the substances concer ned are 
efficacious when used in food as flavourings and their function in feed is essentially the same as in food, no 
further demonstration of efficacy was necessar y. Theref ore, that conclusion can be extrapolat ed to feed. The 
applicant withdrew the application for wate r for drinking, however , it should be possible to use the substances 
concer ned within compo und feeds which are subsequently administered via water . 
(5)  Restr ictions and conditions should be provid ed for to allow better control. Since safety reasons do not require the 
setting of a maximum content and taking into account the re-evaluation performe d by the Authority, 
a recommended content should be indicated on the label of the additive. Where such cont ent is excee ded, certain 
information should be indicated on the label of premixtures, and on the labelling of feed mat erials and 
compo und feed. 
(6)  The Auth ority note d that hazards for the skin, eye contact and respirato ry exposure are recognised. Most 
substances are classified as irritating to the respirato ry system . Consequently , appropr iate prote ctive measures 
should be take n. The Author ity does not consider that there is a need for specifi c requirements of post-market 
monitoring. It also verified the repor t on the method of analysis of the feed additives in feed submitted by the 
Reference Laboratory set up by Regulation (EC) No 1831/2003. 
(7)  The assessment of the substances concer ned shows that the conditions for author isation, as provided for in 
Article 5 of Regulation (EC) No 1831/2003, are satisfied. According ly, the use of those substances should be 
author ised as specified in the Annex to this Regulation. 23.2.2018 L 53/69 Official Jour nal of the European Union EN     
(1)OJ L 268, 18.10.2003, p. 29. 
(2)Council Directive 70/524/EEC of 23 November 1970 concer ning additives in feedingstuffs (OJ L 270, 14.12.1970, p. 1). 
(3)EFSA Journal 2016;14(11):4618. (8) Since safety reasons do not require the immediate application of the modifi cations to the conditions of author is­
ation for the substances concer ned, it is appropr iate to allow a transitional period for inter ested parties to 
prepare themselves to meet the new requirements resulting from the author isation. 
(9)  The measures provi ded for in this Regulation are in accordance with the opinion of the Standing Committee on 
Plants, Animals, Food and Feed, 
HAS ADOPTED THIS REGUL ATION: 
Article 1 
Author isation 
The substances specifi ed in the Annex, belonging to the additive catego ry ‘sensor y additives ’ and to the functional group 
‘flavouri ng compounds’, are author ised as feed additives in animal nutr ition subject to the conditions laid down in that 
Annex. 
Article 2 
Transitional measures 
1. The substances specifi ed in the Annex and premixtures containing those substances, whic h are produced and 
labelled before 15 Sept ember 2018 in accordance with the rules applicable before 15 March 2018 may continue to be 
placed on the mark et and used until the existing stoc ks are exhausted. 
2. Feed mat erials and compo und feed containing the substances as specified in the Annex which are produced and 
labelled before 15 March 2019 in accordance with the rules applicable before 15 March 2018 may continue to be 
placed on the mark et and used until the existing stoc ks are exhausted if they are intende d for food-producing animals. 
3. Feed mat erials and compo und feed containing the substances as specified in the Annex which are produced and 
labelled before 15 March 2020 in accordance with the rules applicable before 15 March 2018 may continue to be 
placed on the mark et and used until the existing stocks are exhaust ed if they are intende d for non-f ood-producing 
animals. 
Article 3 
Entr y into force 
This Regulation shall enter into force on the twentieth day followi ng that of its publication in the Official Journal of the 
European Union. 
This Regulation shall be binding in its entirety and directly applicable in all Member State s. 
Done at Brussels, 15 Febr uary 2018. 
For the Commission 
The President 
Jean-Claude JUNCK ER  23.2.2018 L 53/70 Official Jour nal of the European Union EN     ANNEX 
Identifica ­
tion 
number of 
the additive Name of 
the holder 
of author i­
sation Additive Composi tion, chemical formula, 
descr iption, analytical method Species or 
categor y of 
animal Maximum 
age Minimum 
conten t Maximum 
content 
Other provisions End of pe­
riod 
of author i­
sation mg of active substance/kg 
of compl ete feedingstuff 
with a moisture conten t of 
12 % 
Categor y: Sensor y additiv es. Functional group: Flavour ing compounds 
2b07051 — 3-Hydro xybu ­
tan-2-one Additiv e composition 
3-Hydro xybutan-2-one 
Char acter isation of the activ e sub­
stance 
3-Hydro xybutan-2-one 
Produced by chemical synthesis 
Purity: min. 96 % assa y 
Chemical formula: C4H8O2 
CAS number: 513-86-0 
FLAVIS No: 07.051 
Method of analy sis(1) 
For the determination of 3-hydro ­
xybutan-2-one in the feed additive 
and in feed flavouring premixtures: 
Gas chromat ography mass spectro ­
metr y with retention time locking 
GC-MS-RT L. All animal 
species — — — 1.  The additive shall be incor porated 
into the feed in the form of a pre­
mixture. 
2.In the directions for use of the ad­
ditive and premixtures, the storag e 
and stability conditions shall be in­
dicated. 
3.The recommended maximum con­
tent of the active substance shall be 
5 mg/kg of complet e feedingstuff 
with a moisture conte nt of 12 %. 
4.On the label of the additive the fol­
lowing shall be indicated : 
‘Recommended maximum cont ent 
of the active substance of complet e 
feedingstuff with a moisture con­
tent of 12 %: 5 mg/kg.’ 
5.The functional group, the identif i­
cation number , the name and the 
added amount of the active sub­
stance shall be indicated on the la­
bel of the premixtures and on the 
labelling of feed mater ials and com ­
pound feedingstuffs, if the cont ent 
of the active substance in complet e 
feedingstuff with a moisture con­
tent of 12 % excee ds: 5 mg/kg.  15.3.2028 23.2.2018 L 53/71 Official Jour nal of the European Union EN     Identifica ­
tion 
number of 
the additive Name of 
the holder 
of author i­
sation Additive Composi tion, chemical formula, 
descr iption, analytical method Species or 
categor y of 
animal Maximum 
age Minimum 
conten t Maximum 
content 
Other provisions End of pe­
riod 
of author i­
sation mg of active substance/kg 
of compl ete feedingstuff 
with a moisture conten t of 
12 % 
6.For users of the additive and pre­
mixtures, feed business operators 
shall establish operational proce ­
dures and organisational measures 
to address poten tial risks by inhala ­
tion, dermal contact or eyes con­
tact. Where those risks cannot be 
eliminated or reduced to a mini ­
mum by such procedures and 
measures, the additive and premix ­
tures shall be used with personal 
protective equipment, including 
breathing prot ection, safety glasses 
and gloves.           
2b07060 — Pentan-2,3- 
dione Additiv e composition 
Pentan-2,3-dione 
Char acter isation of the activ e sub­
stance 
Pentan-2,3-dione 
Produced by chemical synthesis 
Purity: min. 93 % assa y 
Chemical formula: C5H8O2 
CAS number: 600-14-6 
FLAVIS No: 07.060 
Method of analy sis(1) 
For the determi nation of pentan- 
2,3-dione in the feed additive and 
in feed flavouri ng premixtures: 
Gas chromat ography mass spectro ­
metr y with retention time locking 
GC-MS-RT L. All animal 
species — — — 1.  The additive shall be incor porated 
into the feed in the form of a pre­
mixture. 
2.In the directions for use of the ad­
ditive and premixtures, the storag e 
and stability conditions shall be in­
dicated. 
3.The recommended maximum con­
tent of the active substance shall be 
5 mg/kg of complet e feedingstuff 
with a moisture conte nt of 12 %. 
4.On the label of the additive the fol­
lowing shall be indicated : 
‘Recommended maximum cont ent 
of the active substance of complet e 
feedingstuff with a moisture con­
tent of 12 %: 5 mg/kg.’  15.3.2028 23.2.2018 L 53/72 Official Jour nal of the European Union EN     Identifica ­
tion 
number of 
the additive Name of 
the holder 
of author i­
sation Additive Composi tion, chemical formula, 
descr iption, analytical method Species or 
categor y of 
animal Maximum 
age Minimum 
conten t Maximum 
content 
Other provisions End of pe­
riod 
of author i­
sation mg of active substance/kg 
of compl ete feedingstuff 
with a moisture conten t of 
12 % 
5.The functional group, the identif i­
cation number , the name and the 
added amount of the active sub­
stance shall be indicated on the la­
bel of the premixtures and on the 
labelling of feed mater ials and com ­
pound feedingstuffs, if the cont ent 
of the active substance in complet e 
feedingstuff with a moisture con­
tent of 12 % excee ds: 5 mg/kg. 
6.For users of the additive and pre­
mixtures, feed business operators 
shall establish operational proce ­
dures and organisational measures 
to address poten tial risks by inhala ­
tion, dermal contact or eyes con­
tact. Where those risks cannot be 
eliminated or reduced to a mini ­
mum by such procedures and 
measures, the additive and premix ­
tures shall be used with personal 
protective equipment, including 
breathing prot ection, safety glasses 
and gloves.           
2b07076 — 3,5-Dimeth yl 
cyclopentan- 
1,2-dione Additiv e composition 
3,5-dimethyl cyclopentan-1,2-dio ­
ne 
Char acter isation of the activ e sub­
stance 
3,5-dimethyl cyclopentan-1,2-dio ­
ne 
Produced by chemical synthesis 
Purity: min. 97 % assa y 
Chemical formula: C7H10O2  All animal 
species — — — 1.  The additive shall be incor porated 
into the feed in the form of a pre­
mixture. 
2.In the directions for use of the ad­
ditive and premixtures, the storag e 
and stability conditions shall be in­
dicated.  15.3.2028 23.2.2018 L 53/73 Official Jour nal of the European Union EN     Identifica ­
tion 
number of 
the additive Name of 
the holder 
of author i­
sation Additive Composi tion, chemical formula, 
descr iption, analytical method Species or 
categor y of 
animal Maximum 
age Minimum 
conten t Maximum 
content 
Other provisions End of pe­
riod 
of author i­
sation mg of active substance/kg 
of compl ete feedingstuff 
with a moisture conten t of 
12 % 
CAS number: 13494-07-0 
FLAVIS No: 07.076 
Method of analy sis(1) 
For the determination of 3,5-di ­
meth yl cyclopentan-1,2-dione in 
the feed additive and in feed fla­
vouring premixtures: 
Gas chromat ography mass spectro ­
metr y with retention time locking 
GC-MS-RT L. 3.The recommended maximum con­
tent of the active substance shall be 
0,5 mg/kg of compl ete feedingstuff 
with a moisture conte nt of 12 %. 
4.On the label of the additive the fol­
lowing shall be indicated : 
‘Recommended maximum cont ent 
of the active substance of complet e 
feedingstuff with a moisture con­
tent of 12 %: 0,5 mg/kg.’ 
5.The functional group, the identif i­
cation number , the name and the 
added amount of the active sub­
stance shall be indicated on the la­
bel of the premixtures and on the 
labelling of feed mater ials and com ­
pound feedingstuffs, if the cont ent 
of the active substance in complet e 
feedingstuff with a moisture con­
tent of 12 % excee ds: 0,5 mg/kg. 
6.For users of the additive and pre­
mixtures, feed business operators 
shall establish operational proce ­
dures and organisational measures 
to address poten tial risks by inhala ­
tion, dermal contact or eyes con­
tact. Where those risks cannot be 
eliminated or reduced to a mini ­
mum by such procedures and 
measures, the additive and premix ­
tures shall be used with personal 
protective equipment, including 
breathing prot ection, safety glasses 
and gloves.           23.2.2018 L 53/74 Official Jour nal of the European Union EN     Identifica ­
tion 
number of 
the additive Name of 
the holder 
of author i­
sation Additive Composi tion, chemical formula, 
descr iption, analytical method Species or 
categor y of 
animal Maximum 
age Minimum 
conten t Maximum 
content 
Other provisions End of pe­
riod 
of author i­
sation mg of active substance/kg 
of compl ete feedingstuff 
with a moisture conten t of 
12 % 
2b07077 — Hexan-3,4- 
dione Additiv e composition 
Hexan-3,4-dione 
Char acter isation of the activ e sub­
stance 
Hexan-3,4-dione 
Produced by chemical synthesis 
Purity: min. 97 % assa y 
Chemical formula: C6H10O2 
CAS number: 4437-51-8 
FLAVIS No: 07.077 
Method of analy sis(1) 
For the determination of hexan- 
3,4-dione in the feed additive and 
in feed flavouri ng premixtures: 
Gas chromat ography mass spectro ­
metr y with retention time locking 
GC-MS-RT L. All animal 
species — — — 1.  The additive shall be incor porated 
into the feed in the form of a pre­
mixture. 
2.In the directions for use of the ad­
ditive and premixtures, the storag e 
and stability conditions shall be in­
dicated. 
3.The recommended maximum con­
tent of the active substance shall be 
5 mg/kg of complet e feedingstuff 
with a moisture conte nt of 12 %. 
4.On the label of the additive the fol­
lowing shall be indicated : 
‘Recommended maximum cont ent 
of the active substance of complet e 
feedingstuff with a moisture con­
tent of 12 %: 5 mg/kg.’ 
5.The functional group, the identif i­
cation number , the name and the 
added amount of the active sub­
stance shall be indicated on the la­
bel of the premixtures and on the 
labelling of feed mater ials and com ­
pound feedingstuffs, if the cont ent 
of the active substance in complet e 
feedingstuff with a moisture con­
tent of 12 % excee ds: 5 mg/kg.  15.3.2028 23.2.2018 L 53/75 Official Jour nal of the European Union EN     Identifica ­
tion 
number of 
the additive Name of 
the holder 
of author i­
sation Additive Composi tion, chemical formula, 
descr iption, analytical method Species or 
categor y of 
animal Maximum 
age Minimum 
conten t Maximum 
content 
Other provisions End of pe­
riod 
of author i­
sation mg of active substance/kg 
of compl ete feedingstuff 
with a moisture conten t of 
12 % 
6.For users of the additive and pre­
mixtures, feed business operators 
shall establish operational proce ­
dures and organisational measures 
to address poten tial risks by inhala ­
tion, dermal contact or eyes con­
tact. Where those risks cannot be 
eliminated or reduced to a mini ­
mum by such procedures and 
measures, the additive and premix ­
tures shall be used with personal 
protective equipment, including 
breathing prot ection, safety glasses 
and gloves.           
2b09186 — Sec-butan-3- 
onyl acetat e Additiv e composition 
Sec-butan-3-ony l acetate 
Char acter isation of the activ e sub­
stance 
Sec-butan-3-ony l acetate 
Produced by chemical synthesis 
Purity: min. 98 % assa y 
Chemical formula: C6H10O3 
CAS number: 4906-24-5 
FLAVIS No: 09.186 
Method of analy sis(1) 
For the determination of sec-bu ­
tan-3-on yl acetat e in the feed addi ­
tive and in feed flavouri ng premix ­
tures: 
Gas chromat ography mass spectro ­
metr y with retention time locking 
GC-MS-RT L. All animal 
species — — — 1.  The additive shall be incor porated 
into the feed in the form of a pre­
mixture. 
2.In the directions for use of the ad­
ditive and premixtures, the storag e 
and stability conditions shall be in­
dicated. 
3.The recommended maximum con­
tent of the active substance shall be 
5 mg/kg of complet e feedingstuff 
with a moisture conte nt of 12 %. 
4.On the label of the additive the fol­
lowing shall be indicated : 
‘Recommended maximum cont ent 
of the active substance of complet e 
feedingstuff with a moisture con­
tent of 12 %: 5 mg/kg.’  15.3.2028 23.2.2018 L 53/76 Official Jour nal of the European Union EN     Identifica ­
tion 
number of 
the additive Name of 
the holder 
of author i­
sation Additive Composi tion, chemical formula, 
descr iption, analytical method Species or 
categor y of 
animal Maximum 
age Minimum 
conten t Maximum 
content 
Other provisions End of pe­
riod 
of author i­
sation mg of active substance/kg 
of compl ete feedingstuff 
with a moisture conten t of 
12 % 
5.The functional group, the identif i­
cation number , the name and the 
added amount of the active sub­
stance shall be indicated on the la­
bel of the premixtures and on the 
labelling of feed mater ials and com ­
pound feedingstuffs, if the cont ent 
of the active substance in complet e 
feedingstuff with a moisture con­
tent of 12 % excee ds: 5 mg/kg. 
6.For users of the additive and pre­
mixtures, feed business operators 
shall establish operational proce ­
dures and organisational measures 
to address poten tial risks by inhala ­
tion, dermal contact or eyes con­
tact. Where those risks cannot be 
eliminated or reduced to a mini ­
mum by such procedures and 
measures, the additive and premix ­
tures shall be used with personal 
protective equipment, including 
breathing prot ection, safety glasses 
and gloves.           
2b07109 — 2,6,6- Tri­
meth ylcy clo­
hex-2-en-1,4- 
dione Additiv e composition 
2,6,6- Trimeth ylcy clohex-2-en-1,4- 
dione 
Char acter isation of the activ e sub­
stance 
2,6,6- Trimeth ylcy clohex-2-en-1,4- 
dione 
Produced by chemical synthesis 
Purity: min. 98 % assa y  All animal 
species — — — 1.  The additive shall be incor porated 
into the feed in the form of a pre­
mixture. 
2.In the directions for use of the ad­
ditive and premixtures, the storag e 
and stability conditions shall be in­
dicated.  15.3.2028 23.2.2018 L 53/77 Official Jour nal of the European Union EN     Identifica ­
tion 
number of 
the additive Name of 
the holder 
of author i­
sation Additive Composi tion, chemical formula, 
descr iption, analytical method Species or 
categor y of 
animal Maximum 
age Minimum 
conten t Maximum 
content 
Other provisions End of pe­
riod 
of author i­
sation mg of active substance/kg 
of compl ete feedingstuff 
with a moisture conten t of 
12 % 
Chemical formula: C9H12O2 
CAS number: 1125-21-9 
FLAVIS No: 07.109 
Method of analy sis(1) 
For the deter mination of 2,6,6-tr i­
meth ylcy clohex-2-en-1,4-dione in 
the feed additive and in feed fla­
vouring premixtures: 
Gas chromat ography mass spectro ­
metr y with retention time locking 
GC-MS-RT L. 3.The recommended maximum con­
tent of the active substance of com ­
plete feedingstuff with a moisture 
content of 12 % shall be: 
—  0,3 mg/kg for pigs and poultr y; 
—  0,5 mg/kg for other species and 
catego ries. 
4.On the label of the additive the fol­
lowing shall be indicated : 
‘Recommended maximum cont ent 
of the active substance of complet e 
feedingstuff with a moisture con­
tent of 12 %: 
—  0,3 mg/kg for pigs and poultr y; 
—  0,5 mg/kg for other species and 
catego ries’. 
5.The functional group, the identif i­
cation number , the name and the 
added amount of the active sub­
stance shall be indicated on the la­
bel of the premixtures and on the 
labelling of feed mater ials and com ­
pound feedingstuffs, if the cont ent 
of the active substance in complet e 
feedingstuff with a moisture con­
tent of 12 % excee ds: 
—  0,3 mg/kg for pigs and poultr y; 
—  0,5 mg/kg for other species and 
catego ries.  23.2.2018 L 53/78 Official Jour nal of the European Union EN     Identifica ­
tion 
number of 
the additive Name of 
the holder 
of author i­
sation Additive Composi tion, chemical formula, 
descr iption, analytical method Species or 
categor y of 
animal Maximum 
age Minimum 
conten t Maximum 
content 
Other provisions End of pe­
riod 
of author i­
sation mg of active substance/kg 
of compl ete feedingstuff 
with a moisture conten t of 
12 % 
6.For users of the additive and pre­
mixtures, feed business operators 
shall establish operational proce ­
dures and organisational measures 
to address poten tial risks by inhala ­
tion, dermal contact or eyes con­
tact. Where those risks cannot be 
eliminated or reduced to a mini ­
mum by such procedures and 
measures, the additive and premix ­
tures shall be used with personal 
protective equipment, including 
breathing prot ection, safety glasses 
and gloves.           
2b07184 — 3-Methy l­
nona-2-,4- 
dione Additiv e composition 
3-Methy lnona-2-,4-dione 
Char acter isation of the activ e sub­
stance 
3-Methy lnona-2-,4-dione 
Produced by chemical synthesis 
Purity: min. 97 % assa y 
Chemical formula: C10H18O2 
CAS number: 113486-29-6 
FLAVIS No: 07.184 
Method of analy sis(1) 
For the determi nation of 3-methyl ­
nona-2-,4-dione in the feed addi ­
tive and in feed flavouri ng premix ­
tures: 
Gas chromat ography mass spectro ­
metr y with retention time locking 
GC-MS-RT L. All animal 
species — — — 1.  The additive shall be incor porated 
into the feed in the form of a pre­
mixture. 
2.In the directions for use of the ad­
ditive and premixtures, the storag e 
and stability conditions shall be in­
dicated. 
3.The recommended maximum con­
tent of the active substance of com ­
plete feedingstuff with a moisture 
content of 12 % shall be: 
—  0,3 mg/kg for pigs and poultr y; 
—  0,5 mg/kg for other species and 
catego ries. 
4.On the label of the additive the fol­
lowing shall be indicated : 
‘Recommended maximum cont ent 
of the active substance of complet e 
feedingstuff with a moisture con­
tent of 12 %: 
—  0,3 mg/kg for pigs and poultr y; 
—  0,5 mg/kg for other species and 
catego ries’.  15.3.2028 23.2.2018 L 53/79 Official Jour nal of the European Union EN     Identifica ­
tion 
number of 
the additive Name of 
the holder 
of author i­
sation Additive Composi tion, chemical formula, 
descr iption, analytical method Species or 
categor y of 
animal Maximum 
age Minimum 
conten t Maximum 
content 
Other provisions End of pe­
riod 
of author i­
sation mg of active substance/kg 
of compl ete feedingstuff 
with a moisture conten t of 
12 % 
5.The functional group, the identif i­
cation number , the name and the 
added amount of the active sub­
stance shall be indicated on the la­
bel of the premixtures and on the 
labelling of feed mater ials and com ­
pound feedingstuffs, if the cont ent 
of the active substance in complet e 
feedingstuff with a moisture con­
tent of 12 % excee ds: 
—  0,3 mg/kg for pigs and poultr y; 
—  0,5 mg/kg for other species and 
catego ries. 
6.For users of the additive and pre­
mixtures, feed business operators 
shall establish operational proce ­
dures and organisational measures 
to address poten tial risks by inhala ­
tion, dermal contact or eyes con­
tact. Where those risks cannot be 
eliminated or reduced to a mini ­
mum by such procedures and 
measures, the additive and premix ­
tures shall be used with personal 
protective equipment, including 
breathing prot ection, safety glasses 
and gloves.           
(1)  Details of the analytical methods are available at the following address of the Reference Laborato ry: https://ec.europa.eu/jrc/en/eurl/feed-addi tives/evaluation-repor ts.   23.2.2018 L 53/80 Official Jour nal of the European Union EN