1 
 EN 
Annexes 1 to 4  
ANNEX I  
 
In Annex II to Regulation (EC) No 1272/2008 , in Part 2, the following section 2.12  is inserted : 
 
‘2.12. Mixtures containing titanium dioxide . 
The label on the packaging of liquid mixtures containing 1% or more of titanium dioxide particles with a diameter equal to or below 10 µm    
shall bear the following statement:  
EUH211: 'Warning! Dangerous droplets may be formed when sprayed. See information supplied by the manufacturer. Comply with th e safety 
instructions .' 
The label o n the packaging of solid mixtures containing 1% or more of titanium dioxide shall bear the following statement:  
EUH212: 'Warning! Dangerous dust may be formed when used. See information supplied by the manufacturer. Comply with the safet y 
instructions .' 
The label on the packaging of liquid and solid mixtures not intended for the general public and not classified as hazardous whi ch are labelled 
with EUH211 or EUH212, shall bear statement EUH210  in addition.   
   
2 
 ANNEX II  
  
In Part 3  of Annex III to Regulation (EC) No 1272/2008, in Table 2.1, the following  rows  EUH 21 1 and EUH 21 2 are inserted:  
 
 
‘EUH211  Language  Warning! Dangerous droplets may be formed when sprayed. See 
information supplied by the manufacturer. Comply with the 
safety instructions.  
EUH212  Language  Warning! Dangerous dust may be formed when us ed. See 
information supplied by the manufacturer. Comply with the 
safety instructions. ’ 
 
   
3 
 ANNEX III  
 
Annex VI to Regulation (EC) No 1272/2008 is amended as follows:  
 
(1) Part 1  is amended as follows:  
 
(a) in point 1.1.3.1 , the following note  V is added:  
 ‘Note V:  
If the substance is placed on the market as fibres (with diameter < 3 μm, length > 5 μm and aspect ratio ≥ 3:1) or particles of the 
substance fulfilling the WHO fibre criteria or as particles w ith modified surface chemistry their hazardous properties must be evaluated in 
accordance with Title II of Regulation (EC) No 1272/2008  to assess whether a higher category (Carc.  1B or 1A) and/or additional routes 
of exposure (oral or dermal) should be ap plied.’ ; 
(b) in point 1.1.3.2, the following note 10 is added:  
  ‘Note 10:  
The classification as a carcinogen by inhalation applies only to mixtures placed on the market in powder form containing 1% o r more of 
titanium dioxide particles with diameter ≤ 10 µm.’;  
 
(2) in Part 3, Table 3 is amended as follows:  
 
 
(a) the rows  corresponding to index numbers 604 -083-00-X and 611 -159-00-6 are deleted ; 
 
(b) the rows  corresponding to index numbers  015-189-00-5, 027 -001-00-9, 028 -018-00-4, 603 -023-00-X, 605 -005-00-7, 606-047-00-9, 
607-232-00-7, 607 -247-00-9, 608 -039-00-0, 613 -054-00-0, 616 -018-00-2 and 648 -055-00-5 are replaced by the following rows 
respectively:  
 
 
 
  
4 
 Index No  Chemical name  EC No  CAS No  Classification  Labelling  Specific Conc. 
Limits, M -
factors and 
ATEs  Notes  
Hazard Class and 
Category Code(s)  Hazard 
statement 
Code(s)  Pictogram, 
Signal 
Word   Code(s)  Hazard 
statement 
Code(s)  Suppl. 
Hazard 
statement 
Code(s)  
‘015-189-00-5 
 phenyl bis(2,4,6 -trimethylbenzoyl) -
phosphine oxide  423-340-5 162881 -26-7 Skin Sens. 1A  
Aquatic Chronic 4  
 H317  
H413  
  
 GHS07  
Wng  
 H317  
H413’  
    
‘027-001-00-9 cobalt  231-158-0 7440 -48-4 Carc. 1B  
Muta. 2  
Repr. 1B   
Resp. Sens. 1  
Skin Sens. 1  
Aquatic Chronic 4  
 H350  
H341  
H360F   
H334  
H317  
H413  GHS08  
Dgr H350  
H341  
H360F   
H334  
H317  
H413’     
‘028-018-00-4 
 nickel bis(sulfamidate);  
nickel sulfamate  237-396-1 13770 -89-3 Carc. 1A  
Muta. 2  
Repr. 1B  
Acute Tox. 4  
STOT RE 1  
Resp. Sens. 1  
Skin Sens. 1  
Aquatic Acute 1  
Aquatic Chronic 1  H350i  
H341  
H360D***  
H302  
H372**  
H334  
H317  
H400  
H410  GHS08  
GHS07  
GHS09  
Dgr H350i  
H341  
H360D***  
H302  
H372**  
H334  
H317  
H410   oral: ATE = 853 
mg/kg bw 
(anhydrate)  
oral: ATE = 
1098 mg/kg bw 
(tetrahydrate)  
 
STOT RE 1;  
H372: C ≥ 1 %  
STOT RE 2;  
H373: 0,1 % ≤ C 
< 1 %  
Skin Sens. 1;  
H317: C ≥ 
0,01 %  
 
M=1’  H 
‘603-023-00-X ethylene oxide;  
oxirane  200-849-9 75-21-8 Flam. Gas 1  
Press. Gas  
Carc. 1B  
Muta. 1B  
Repr. 1B  
Acute Tox. 3  
Acute Tox. 3  
STOT SE 3  
STOT SE 3  
STOT RE 1  
Skin Corr. 1  
Eye Dam. 1  
 H220  
H350  
H340  
H360Fd  
H331  
H301  
H335  
H336  
H372 
(nervous 
system)  
H314  
H318  GHS02  
GHS08  
GHS06  
GHS05  
Dgr  
 
 H220  
H350  
H340  
H360Fd  
H331  
H301  
H335  
H336  
H372 
(nervous 
system)  
H314   inhalation: ATE 
= 700ppm 
(gases)  
oral: ATE = 100 
mg/kg bw’  U  
5 
 Index No  Chemical name  EC No  CAS No  Classification  Labelling  Specific Conc. 
Limits, M -
factors and 
ATEs  Notes  
Hazard Class and 
Category Code(s)  Hazard 
statement 
Code(s)  Pictogram, 
Signal 
Word   Code(s)  Hazard 
statement 
Code(s)  Suppl. 
Hazard 
statement 
Code(s)  
‘605-005-00-7 metaldehyde (ISO);  
2,4,6,8 -tetramethyl -1,3,5,7 -
tetraoxacyclooctane  203-600-2 108-62-3 Flam. Sol. 2  
Repr. 2  
Acute Tox. 3  
Aquatic Chronic 3  H228  
H361f  
H301  
H412  
 GHS02  
GHS08  
GHS06  
Dgr H228  
H361f  
H301  
H412   oral: ATE = 283 
mg/kg bw’   
‘606-047-00-9 
 2-benzyl -2-dimethylamino -4'-
morpholinobutyrophenone  404-360-3 119313 -12-1 Repr. 1B  
Aquatic Acute 1  
Aquatic Chronic 1  H360D  
H400  
H410  GHS08  
GHS09  
Dgr H360D  
H410’     
‘607-232-00-7 pyridate (ISO);  
O-(6-chloro -3-phenylpyridazin -4-
yl) S-octyl thiocarbonate  259-686-7 55512 -33-9 Acute Tox. 4  
Skin Irrit. 2  
Skin Sens. 1  
Aquatic Acute 1  
Aquatic Chronic 1  
 H302  
H315  
H317  
H400  
H410  
 GSH07  
GHS09  
Wng  H302  
H315  
H317  
H410  
  oral: ATE = 500 
mg/kg bw  
 
M=1  
M=10’   
‘607-247-00-9 
 dodecyl methacrylate  205-570-6 142-90-5 STOT SE 3  
 H335  GHS07  
Wng  
 H335  
  STOT SE 3; 
H335: C ≥ 10%’   
‘608-039-00-0 
 2-phenylhexanenitrile  423-460-8 3508 -98-3 Acute Tox. 4  
Aquatic Chronic 2  H302  
H411  GHS07  
GHS09  
Wng  H302  
H411   oral: 
ATE = 500 
mg/kg bw’   
‘613-054-00-0 
 thiabendazole (ISO);  
2-(thiazol -4-yl)benzimidazole  205-725-8 148-79-8 Aquatic Acute 1 
Aquatic Chronic 1 H400  
H410  GHS09  
Wng  H410   M=1  
M=1’   
‘616-018-00-2 
 diethyltoluamide (ISO):                                    
N,N-diethyl -m-toluamide;                                      
[deet]  205-149-7 134-62-3 Acute Tox. 4  
Skin Irrit. 2  
Eye Irrit. 2 
 H302  
H315  
H319  
 GHS07  
Wng  
 H302  
H315  
H319  
  oral: 
ATE = 1892 
mg/kg bw’   
 
  
6 
 (c) the following  rows  are inserted:  
 
Index No  Chemical Name  EC No  CAS No  Classification  Labelling  Specific Conc. Limits, 
M-factors and ATEs  Notes  
Hazard Class 
and Category 
Code(s)  Hazard 
statement 
Code(s)  Pictogram, 
Signal 
Word   Code(s)  Hazard 
statement 
Code(s)  Suppl. Hazard 
statement 
Code(s)    
‘022-006-002 titanium dioxide;  
[in a powder form containing 1% 
or more of particles with diameter 
≤ 10 µm]  236-675-5 13463 -67-7 Carc. 2  H351 
(inhalation)  GHS08  
Wng  H351 
(inhalation)    V, 10  
080-004-00-7 methylmercuric chloride  204-064-2 115-09-3 Carc. 2  
Repr. 1A  
Lact.  
Acute Tox. 2  
Acute Tox. 2  
Acute Tox. 2  
STOT RE 1  
Aquatic Acute 1  
Aquatic Chronic 
1  H351  
H360Df  
H362  
H330  
H310  
H300  
H372 (nervous 
system, 
kidneys)  
H400  
H410  GHS08  
GHS06  
GHS09  
Dgr  
 H351  
H360Df  
H362  
H330  
H310  
H300  
H372 (nervous 
system, 
kidneys)  
H410   inhalation: ATE = 0,05 
mg/l (dusts or mists)  
dermal: ATE = 50 mg/kg 
bw 
oral: ATE = 5 mg/kg bw  
 1 
601-090-00-X benzo[ rst]pentaphene  205-877-5 189-55-9 Carc. 1B  
Muta. 2  
 H350  
H341  
 GHS08  
Dgr H350  
H341  
    
601-091-00-5 dibenzo[ b,def ]chrysene;  
dibenzo[ a,h]pyrene  205-878-0 189-64-0 Carc. 1B  
Muta. 2  
 H350  
H341  
 GHS08  
Dgr H350  
H341  
    
603-236-00-8 ethanol, 2,2' -iminobis -, N-(C13 -
15-branched and linear alkyl) 
derivs.  308-208-6 97925 -95-6 Repr. 1B  H360D  GHS08  
Dgr H360D     
607-733-00-0 
 cyflumetofen (ISO);  
2-methoxyethyl ( RS)-2-(4-tert-
butylphenyl) -2-cyano -3-oxo-3-
(α,α,α -trifluoro -o-tolyl)propionate  - 400882 -07-7 Carc. 2  
Skin Sens. 1A  
 H351  
H317  GHS08  
GHS07  
Wng  H351  
H317      
7 
 Index No  Chemical Name  EC No  CAS No  Classification  Labelling  Specific Conc. Limits, 
M-factors and ATEs  Notes  
Hazard Class 
and Category 
Code(s)  Hazard 
statement 
Code(s)  Pictogram, 
Signal 
Word   Code(s)  Hazard 
statement 
Code(s)  Suppl. Hazard 
statement 
Code(s)    
607-734-00-6 pentapotassium 2,2’,2’’,2’’’,2’’’’ -
(ethane -1,2-
diylnitrilo)pentaacetate  404-290-3 7216 -95-7 Repr. 1B  
Acute Tox. 4 
STOT RE 2  
Eye Irrit. 2  H360D  
H332  
H373 
(inhalation)  
H319  GHS08  
GHS07  
Dgr H360D  
H332  
H373 
(inhalation)  
H319   inhalation:  
ATE = 1,5 mg/l (dusts or 
mists)   
607-735-00-1 N-
carboxymethyliminobis(ethylene
nitrilo)tetra(acetic acid)  200-652-8 67-43-6 Repr. 1B  
Acute Tox. 4 
STOT RE 2  
Eye Irrit. 2  H360D  
H332  
H373 
(inhalation)  
H319  GHS08  
GHS07  
Dgr H360D  
H332  
H373 
(inhalation)  
H319   inhalation:  
ATE = 1,5 mg/l (dusts or 
mists)  
607-736-00-7 pentasodium 
(carboxylatomethyl)iminobis(eth
ylenenitrilo)tetraacetate  205-391-3 140-01-2 Repr. 1B  
Acute Tox. 4  
STOT RE 2  
 H360D  
H332  
H373 
(inhalation)  
 GHS08  
GHS07  
Dgr H360D  
H332  
H373 
(inhalation)  
  inhalation:  
ATE = 1,5 mg/l (dusts or 
mists)  
607-737-00-2 diisohexyl phthalate  276-090-2 71850 -09-4 Repr. 1B  H360FD  GHS08  
Dgr H360FD     
608-069-00-4 fludioxonil (ISO); 4 -(2,2-
difluoro -1,3-benzodioxol -4-yl)-
1H-pyrrole -3-carbonitrile  - 131341 -86-1 Aquatic Acute 1  
Aquatic Chronic 
1 H400  
H410  GHS09  
Wng  H410   M=1  
M=10   
613-329-00-5 halosulfuron -methyl (ISO);  
methyl 3 -chloro -5-{[(4,6 -
dimethoxypyrimidin -2-
yl)carbamoyl]sulfamoyl} -1-
methyl -1H-pyrazole -4-
carboxylate  - 100784 -20-1 Repr. 1B  
Aquatic Acute 1  
Aquatic Chronic 
1 H360D  
H400  
H410  GHS08  
GHS09  
Dgr H360D  
H410    
M=1000  
M=1000   
613-330-00-0 
 2-methylimidazole  211-765-7 693-98-1 Repr. 1B  H360Df  GHS08  
Dgr H360Df      
8 
 Index No  Chemical Name  EC No  CAS No  Classification  Labelling  Specific Conc. Limits, 
M-factors and ATEs  Notes  
Hazard Class 
and Category 
Code(s)  Hazard 
statement 
Code(s)  Pictogram, 
Signal 
Word   Code(s)  Hazard 
statement 
Code(s)  Suppl. Hazard 
statement 
Code(s)    
616-225-00-8 (RS)-2-methoxy -N-methyl -2-[α-
(2,5-xylyloxy) -o-tolyl]acetamide; 
mandestrobin  - 173662 -97-0 Aquatic Acute 1 
Aquatic Chronic 
1 H400  
H410  GHS09  
Wng  H410   M=1  
M=10   
616-226-00-3 carboxin (ISO);  
2-methyl -N-phenyl -5,6-dihydro -
1,4-oxathiine -3-carboxamide; 
5,6-dihydro -2-methyl -1,4-
oxathiine -3-carboxanilide  226-031-1 5234 -68-4 STOT RE 2  
Skin Sens. 1  
Aquatic Acute 1  
Aquatic Chronic 
1 H373 (kidneys)  
H317  
H400  
H410  GHS08  
GHS07  
GHS09  
Wng  H373 (kidneys)  
H317  
H410    
 
 
M=1  
M=1   
616-227-00-9 metaflumizone (ISO);  
(EZ)-2'-[2-(4-cyanophenyl) -1-
(α,α,α -trifluoro -m-
tolyl)ethylidene] -[4-
(trifluoromethoxy)phenyl]carbani
lohydrazide [ E-isomer > 90%, Z-
isomer <10% relative content]; 
[1] 
(E)-2'-[2-(4-cyanophenyl) -1-
(α,α,α -trifluoro -m-
tolyl)ethylidene] -[4-
(trifluoromethoxy)phen yl]carbani
lohydrazide [2]  - 139968 -49-3 
[1] 
852403 -68-0 
[2] Repr. 2  
Lact.  
STOT RE 2  H361fd  
H362  
H373  GHS08  
Wng  H361fd  
H362  
H373     
650-056-00-0 dibutylbis(pentane -2,4-dionato -
O,O')tin 245-152-0 22673 -19-4 Repr. 1B  
STOT RE 1  H360FD  
H372 (immune 
system)  GHS08  
Dgr H360FD  
H372 (immune 
system)’     
 
   
9 
 ANNEX IV   
  
In the Annex to Commission Regulation (EU) 2018/669 , the row with Index No ‘ 648-055-00-5’ is replaced by the following:  
 
 
‘648-055-00-5 pitch, coal tar, high -temp.;  
[The residue from the distillation of 
high temperature coal tar. A black 
solid with an approximate softening 
point from 30 °C to 180 °C (86 °F to 
356 °F). Composed primarily of a 
complex mixture of three or more 
membered condensed ring aromatic 
hydrocarbons.]  266-028-2 65996 -93-2 Carc. 1A  
Muta. 1B  
Repr. 1B  H350  
H340  
H360FD  GHS08  
Dgr H350  
H340  
H360FD’