1 
 GCC STANDARDIZATION ORGANIZATION (GSO) 
 
 
 
 
 
Draft: Final  
 
GSO CAC/MRL 02:2009 
 
 
 
 
MAXIMUM  RESIDUES LIMITS (MRLs) OF VETERINARY DRUGS IN 
FOOD  
 
 
 
 
 
 
Prepared by:  
Gulf technical committee for standards of food and agriculture products  
___________________________________________________________________________________________________________  
This document is a draft Gulf standard circulated for comments, it is therefore, subject to 
change, and may not be referred it as a Gulf standard, u ntil approved by the Board of 
Directors.  
ICS: 67.040.00  2 
  
FOREWORD  
 
GCC Standardization Organization (GSO) is a regional Organization which consists 
of the National Standards Bodies of GCC member States. One of GSO main 
functions is to issue Gulf Standards /Technical regulations through specialized 
technical committees (TCs).  
 
GSO through the technical program of committee TC No.:5  "Technical committee 
for standards of food and agriculture products  " has updated  this Standard  GSO 
CAC/MR 02:2009 " MAXIMUM RES IDUES LIMITS (MRLs) OF VETERINARY 
DRUGS IN FOOD  ". The Draft Standard has been prepared by Kingdom of Saudi 
Arabia . 
 
This standard has been approved as a Gulf  (Standard /Technical Regulation ) by 
GSO Board of Directors  in its meeting No.(       ),held on                                 /     /   
H ,      /     /              G.  
The approved standard will replace and supersede the GSO standard No.                         
(GSO CAC/MR 02:2009)  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 3 
 MAXIMUM  RESIDUES LIMITS (MRLs) OF VETERINARY DRUGS  IN 
FOOD  
 
 
1. SCOPE AND FIELD OF APPLICATION  
 This standard is concerned with maximum residues limits for the following veterinary 
drugs in food  and food products of animal origin.  Furthermore, the present GSO 
standard has an appendix  referring  to the withdrawal periods from animal's body as 
well as residue markers and methods of detection.  
 
 
2. COMPLEMENTARY REFERENCES  
2.1 GS 592/1995 “Method of Sampling for Meat and Meat Products”.  
2.2 Draft Gulf Standard which are concerned with “Method of Sampling for Meat Products 
for Determination of Residues of Veterinary Drugs”.  
2.3 Gulf Standard to be approved by G.C.C. on “Methods for Determination of Veterinary 
Drugs Residues in M eat and Meat Products”.  
 
3. DEFINITIONS  
3.1 Veterinary drug:   means any substance applied or administered to any food producing 
animal, such as meat or milk producing animals, poultry, fish or bees, whether used for 
therapeutic, prophylactic or diagnosti c purposes or as growth promoters.  
 
3.2 Residues of veterinary drugs:   residues of substances which may occur in food 
commodities of animal origin as a result of veterinary drugs uses. Those include the 
parent compounds and/or their metabolites as well as  residues of associated impurities 
of the veterinary drug concerned.  
 
3.3 Maximum residue limit (MRL):  is the maximum level of a residue resulting from the 
use of a veterinary drug according to good veterinary and animal husbandry practice 
that is recommen ded by International Authorities as the Codex Alimentarius 
Commission and other International authorities and committees to be legally permitted 
or recognized as acceptable in or on a food.  The concentration is expressed in 
micrograms of residue per kilog ram (µg/kg) of the commodity.  
 
3.4        Acceptable Daily Intake (ADI) : is the amount of a veterinary drug, expressed on a body 
weight basis, that can be ingested daily over an entire human lifetime without any 
appreciable health risk (standard man , 60 k g). 
4. REQUIREMETNS  
 Veterinary drugs residues limits in food of animal origin shall not exceed the limits 
given against each in the following tables.  4 
 5.    LIST OF VETERINARY DRUGS :  
No. Drug  Page  No. Drug  Page  
1 Abamectin  49 78 Mebendazol  55 
2 Albendazole  50 79 Melengestrol acetate  72 
3 Amitraz  62 80 Meloxicam  70 
4 Amoxicillin  14 81 Methyl benzoquate  46 
5 Ampicillin  15 82 Monensin  46 
6 Amprolium  42 83 Monepantel  55 
7 Apramycin  9 84 Moxidectin  56 
8 Arsanilic acid  73 85 Narasin  47 
9 Atropine sulfate  77 86 Natamycin  42 
10 Avermectin  51 87 Neomycin  11 
11 Avilamycin  27 88 Nicarbazin  47 
12 Bacitracin  28 89 Nitobimin  57 
13 Benzyl penicillin  15 90 Nitroxynil  57 
14 Bromhexine  76 91 Novobiocin  7 
15 Carprofen  69 92 Nystatin  42 
16 Cefalonium  13 93 Oleandomycin  24 
17 Cefapirin  13 94 Ormetoprim  48 
18 Ceftiofur  13 95 Oxfendazole  58 
19 Cefuroxime  14 96 Oxyclozanide  59 
20 Chlortetracycline  39 97 Oxytetracycline  40 
21 Clazuril  43 98 Oxytocin  72 
22 Clenbuterol  73 99 Permethrin  68 
23 Clopidol  43 100 Phoxim  68 
24 Cloprostenol  72 101 Piperazine  59 
25 Closantel  52 102 Pirlymicin  23 
26 Cloxacillin  16 103 Poloxalene  77 
27 Colistin  28 104 Polymixin B  29 
28 Cyhalothrin  63 105 Praziquantel  59 
29 Cyfluthrin  64 106 Prednisolone  71 
30 Cypermethrin  65 107 Procaine benzyl penicillin  17 
31 Cyromazine  66 108 Procaine HCl  75 5 
 32 Danofloxacin  19 109 Progesterone  73 
33 Decoquinate  43 110 Ractopamine  74 
34 Deltamethrin  66 111 Rafoxanide  59 
35 Derquantel  52 112 Robenidine  hydrochloride  48 
36 Dexamethasone  71 113 Roxarsone  74 
37 Diazinon  67 114 Salinomycin Sodium  48 
38 Diclazuril  44 115 Sarafloxacin  22 
39 Diclofenac  70 116 Semduramycin  48 
40 Dicyclanil  67 117 Spectinomycin  8 
41 Difloxacin  20 118 Spiramycin  25 
42 Dihydrostreptomycin  9 119 Streptomycin  12 
43 Diminazene  61 120 Sulfabenzamide        30 
44 Dinitolmide (Zoalene)  44 121 Sulfacetamide  30 
45 Doramectin  52 122 Sulfachlorpyridazine  31 
46 Doxapram HCl  75 123 Sulfadiazine  31 
47 Doxycycline  39 124 Sulfadimethoxine  32 
48 Emamectin  68 125 Sulfadimidine 
(Sulfamethazine)  32 
49 Enrofloxacin  20 126 Sulfadoxine  33 
50 Epinephrine  76 127 Sulfaethoxypyridazine  34 
51 Eprinomectin  53 128 Sulfaguanidine  34 
52 Erythromycin  23 129 Sulfamerazine  35 
53 Estradiol -beta  72 130 Sulfanilamide  36 
54 Etamiphylline camsilate  76 131 Sulfanitran  36 
55 Ethopabate  44 132 Sulfapyridine  37 
56 Febantel  53 133 Sulfaquinoxaline  37 
57 Fenbendazole  53 134 Sulfathiazole  38 
58 Florfenicol  18 135 Teflubenzuron  69 
59 Fluazuron  68 136 Testosterone  73 
60 Flubendazole  54 137 Tetracycline  41 
61 Flumequine  21 138 Thiabendazole  60 
62 Flunixin meglumine  70 139 Thiamphenicol  18 
63 Gentamicin  10 140 Tiamulin  27 
64 Gonadotrophin  72 141 Tilmicosin  25 6 
 65 Halofuginone 
hydrobromide  45 142 Tolfenamic  acid  71 
66 Hydrochlorothiazide  77 143 Toltrazuril  48 
67 Hydrocortisone  71 144 Trenbolone  acetate  74 
68 Imidocarb  61 145 Tricaine methanesulfonate  75 
69 Isometamidium  62 146 Trichlorfon (metrifonate)  69 
70 Ivermectin  54 147 Triclabendazole  60 
71 Ketamine  75 148 Trimethoprim  18 
72 Ketoprofen  70 149 Tulathromycin  26 
73 Lasalocid Sodium  45 150 Tylosin  26 
74 Levamisole  54 151 Virginiamycin  29 
75 Lincomycin  22 152 Zeranol  74 
76 Maduramicin Ammonium  46 153 Zilpaterol  74 
77 Marbofloxacin  22    
  
6. MAXIMUM RESIDUE LIMITS (MRLs) OF VETERINARY DRUGS IN FOOD  
6.1. MAXIMUM RESIDUE LIMITS (MRLs) OF ANTIBACTERIAL DRUGS  
 
Drug  groups  Food commodity   
MRL 
g/kg 
  
References  
(MRL)  Species  Tissue or 
product  
6.1.1. AMINOCOUMARIN          
          ANTIBIOTIS  
 
6.1.1.1. Novobiocin  
 
Acceptable Daily Intake (ADI)  
1.25 μg/kg  
body weight   
 
 
Cattle   
 
Muscle   
 
100  
 
 
 
Australian standard 
MRL, 2012  Liver  100 
Kidney  100 
Milk  100 
6.1.2. AMINOCYCLITOL            
          ANTIBIOTICS  
 
6.1.2.1. Spectinomycin  
 
Acceptable Daily Intake (ADI)  
0 - 40 μg/kg   
 
 
Cattle   
 
 
Muscle   
 
 
500  
 
 
CAC/MRL 2 -2011  
Liver  1000   
Australian standard Kidney  1000  7 
 body weight  Fat 1000  MRL, 2012  
 
 
Sheep  Muscle  500  
 
CAC/MRL 2 -2011  Liver  2000  
Kidney  5000  
Fat 2000  
 
 
 
Goat  Muscle  1000   
 
Australian standard 
MRL, 2012  Liver  1000  
Kidney  1000  
Fat 1000  
 
 
Camel  Muscle  1000   
 
Australian standard 
MRL, 2012  Liver  1000  
Kidney  1000  
Fat 1000  
 
 
 
Chicken  Muscle  100  
 
 
Canadian MRL 2011  Liver  100 
Kidney  100 
Fat /skin  100 
Eggs  100 
6.1.3. AMINOGLYCOSIDES       
          ANTIBIOTICS  
 
6.1.3.1. Apramycin  
Acceptable Daily Intake (ADI)  
0–30  μg/kg  
body weight  
  
 
Cattle  Muscle  50  
Australian standard 
MRL, 2012  Liver  2000  
Kidney  20000  
Fat 2000  
 
 
Sheep  Muscle  50  
Australian standard 
MRL, 2012  Liver  2000  
Kidney  2000  
Fat 2000  8 
  
Goat  Muscle  50  
Australian standard 
MRL, 2012  Liver  2000  
Kidney  2000  
Fat 2000  
 
 
Camel  Muscle  50  
Australian standard 
MRL, 2012  Liver  2000  
Kidney  2000  
Fat 2000  
Chicken  Muscle  50  
 
 
 
 
 
Australian standard 
MRL, 2012  Liver  1000  
Kidney  1000  
  Fat 
 1000  
 
 
Turkey  Muscle  50 
Liver  1000  
Kidney  1000  
Fat 1000  
6.1.3.2.  Dihydrostreptomycin  
Acceptable Daily Intake (ADI)  
0-50 μg/kg  
body weight  
 
 
 
 
 
 
  
Cattle  Muscle  300  
Australian standard 
MRL, 2012  Liver  300 
Kidney  300 
Fat 500  
Canadian MRL, 2011  
Milk 
(µg/l)  125 
Sheep  
 
 Muscle  300  
Australian standard 
MRL, 2012  
 
CAC/MRL 2 -2011  Liver  300 
Kidney  300 
Fat 600 9 
  
 
 
 
 
 
 
 
 
 Milk 
(µg/l)  200 
 
Goat  Muscle  300  
 
Australian standard 
MRL, 2012  
 Liver  300 
Kidney  300 
Milk  
(µg/l)  200 
 
Camel  Muscle  300  
Australian standard 
MRL, 2012  
 Liver  300 
Kidney  300 
Milk 
(µg/l)  200 
 
Chicken  Muscle  600  
 
CAC/MRL 2 -2011  Liver  600 
Kidney  1000  
Fat /skin  600 
6.1.3.3.  Gentamicin   
 
Acceptable Daily Intake (ADI)   
0.05 mg/kg   
body weight  
  
Cattle  Muscle  100  
 
 
 
 
 
 
 
 
Canadian MRL  (2011)  
 Liver  500 
Kidney  1000  
Fat 100 
Milk 
(µg/l)  100 
 
Chicken  Muscle  100 
Liver  100 
Kidney  100 
Fat /skin  100 
 
Turkey  Muscle  100 
Liver  100 10 
 Kidney  100 
Fat 100 
6.1.3.4.  Neomycin  
 
Acceptable Daily Intake (ADI)  
0.06 mg/kg  
body weight  
 Cattle  Muscle  500  
 
 
 
CAC/MRL 2 -2012 
 
 
 
 
 
CAC/MRL 2 -2011 
 Liver  500 
Kidney  10000  
Fat 500 
Milk 
(µg/l)  1500  
 
Sheep  Muscle  500 
Liver  500 
Kidney  10000  
Fat 500 
Milk 
(µg/l)  1500  Australian standard 
MRL, 2012  
 
Goat  Muscle  500  
CAC/MRL 2 -2011  
 Liver  500 
Kidney  10000  
Fat 500 
Milk 
(µg/l)  1500  Australian standard 
MRL, 2012  
 
Camel  Muscle  500  
Australian standard 
MRL, 2012  Fat 500 
Milk  
(µg/l)  1500  
 
Chicken  Muscle  500  
 
CAC/MRL 2 -2011  Liver  500 
Kidney  10000  
Fat /skin  500 11 
 Eggs  500 
 
Turkey  Muscle  500  
 
 
CAC/MRL 2 -2011  
 
 Liver  500 
Kidney  1000  
Fat /skin  500 
 
Duck  Muscle  500  
CAC/MRL 2 -2011  Liver  500 
Kidney  10000  
Fat /skin  500 
6.1.3.5.  Streptomycin  
 
Acceptable Daily Intake (ADI)  
0-50 μg/kg  
body weight  
 Cattle  Muscle  300  
Australian standard 
MRL, 2012  Liver  300 
Kidney  300 
Fat 500  
Canadian MRL, 2011  
Milk 
(µg/l)  125 
Sheep  Muscle  300  
Australian standard 
MRL, 2012  
 
CAC/MRL 2 -2011  Liver  300 
Kidney  300 
Fat 600 
Milk 
(µg/l)  200 
Goat  Muscle  300  
 
Australian standard 
MRL, 2012  
 Liver  300 
Kidney  300 
Milk  
(µg/l)  200 
Camel  Muscle  300  12 
 Liver  300 Australian standard 
MRL, 2012  
 Kidney  300 
Milk 
(µg/l)  200 
Chicken  Muscle  600 CAC/MRL 2 -2011  
Liver  600 
Kidney  1000  
Fat /skin  600 
6.1.4. BETA  LACTAM  
6.1.4.1. Cephalosporins  
6.1.4.1. 1. Cefalonium  
Acceptable Daily Intake (ADI)  
0 - 20 μg /kg 
body weight   
Cattle  Muscle  100  
 
Australian standard 
MRL, 2012  Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l)  20 
6.1.4.1. 2. Cefapirin  
Acceptable Daily Intake (ADI)  
0 - 0.02 mg /kg 
body weight  
 Cattle  Muscle  20  
 
 
Australian standard 
MRL, 2012  Liver  20 
Kidney  20 
Fat 20 
Milk 
(µg/l)  10 
6.1.4.1.3.  Ceftiofur  
Acceptable Daily Intake (ADI)  
0-50 μg /kg 
body weight  
 Catlle  Muscle  100 Australian standard 
MRL, 2012  
Liver  2000  CAC/MRL 2 -2011  
Kidney  2000   
Australian standard 
MRL, 2012  Fat 500 
Milk 
(µg/l)  100 CAC/MRL 2 -2011  
Australian standard 
MRL, 2012  
Sheep  Muscle  1000   13 
 Liver  2000   
 
Canadian MRL, 2011  Kidney  6000  
Fat 2000  
6.1.4.1.4.  Cefuroxime  
Acceptable Daily Intake (ADI)  
0 - 30 μg /kg 
body weight  
 Cattle  Muscle  100  
 
 
Australian standard 
MRL, 2012  Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l)  100 
6.1.4.2. Penicillins  
6.1.4.2.1.  Amoxicillin  
 
Acceptable Daily Intake (ADI)  
0 – 0.7 μg/kg  
 body weight  
 
 
 
 
 
  
 
Cattle  
 Muscle  10  
Australian standard 
MRL, 2012  Liver  10 
Kidney  10 
Fat 10 
Milk(μg/l)  4 JECFA/75/SC – 2012  
 
Sheep  
 
 
 Muscle  10  
 
 
Australian standard 
MRL, 2012  
 Liver  10 
Kidney  10 
Fat 10 
Milk  4 JECFA/75/SC – 2012  
Goat  Meat  10  
Australian standard 
MRL, 2012  
 Liver  10 
Kidney  10 
Fat 10 
 
Camel  Muscle  10  
Australian standard 
MRL, 2012  Liver  10 
Kidney  10 
Fat 10 14 
 Chicken  Muscle  10  
Australian standard 
MRL, 2012  
Canadian MRL, 2011  Liver  10 
Kidney  10 
Fat 10 
6.1.4.2.2. Ampicillin  
Acceptable Daily Intake (ADI)  
200 μg/kg  
 body weight   
 
Cattle  
 Muscle  10   
Canadian MRL, 2011  Liver  10 
Kidney  10 
Fat 10 
Milk  
(μg/l)  10 Australian standard 
MRL, 2012  
Canadian MRL, 2011  
6.1.4.2.3.  Benzyl penicillin   
 
Acceptable Daily Intake (ADI)  
30 μg penicillin/person/day  
 
 
 
 
 
 
 
 
 Cattle  Muscle  50  
 
CAC/MRL 2 -2011  
Canadian MRL, 2011  Liver  50 
Kidney  50 
Fat 50 
Milk 
(µg/l)  1.5 
Sheep  
 
 
 
 
 
 Muscle  50  
 
Canadian MRL, 2011  
 
 
 
 Liver  50 
Kidney  50 
Fat 50 
Milk 
(µg/l)  1.5 
Goat  Muscle  50  
CAC/MRL 2 -2011  
Australian standard 
MRL, 2012  
 Liver  50 
Kidney  50 
Milk 
(µg/l)  1.5 15 
 Camel  Muscle  50  
CAC/MRL 2 -2011  
 
Australian standard 
MRL, 2012  Liver  50 
Kidney  50 
Milk 
(µg/l)  1.5 
 
Chicken  Muscle  50  
CAC/MRL 2-2011  
 
Canadian MRL, 2011  
  
 Liver  50 
Kidney  50 
Fat /skin  50 
Turkey  Muscle  10  
 
Canadian MRL, 2011  Liver  10 
Kidney  10 
Fat /skin  10 
6.1.4.2.4. Cloxacillin  
Acceptable Daily Intake (ADI)  
200 ug/kg  
body weight  
 Cattle  Muscle  10  
 
Canadian MRL, 2011  Liver  10 
Kidney  10 
Fat 10 
Milk 
(µg/l)  10 Australian standard 
MRL, 2012  
Sheep  
Muscle  300  
 
 
PUBLIC HEALTH 
(ANIMALS AND 
BIRDS) (CHEMICAL 
RESIDUES) 
REGULATION,http://w
ww.legislation.gov.hk/bli
s_ind.nsf/CURALLENG
DOC/4D1FA97EA098B
39C48256A7F001792E0Liver  300 
Kidney  300 
Goat  Muscle  300 
Liver  300 
Kidney  300 
Camel  Muscle  300 16 
 Liver  300 ?OpenDocument  
 
Kidney  300 
6.1.4.2.5. Procaine benzyl              
                 penicillin  
 
Acceptable Daily Intake (ADI)   
30 μg  penicillin/person/day  
 Cattle  Muscle  50 
 
CAC/MRL 2 -2011  
Australian standard 
MRL, 2012  Liver  50 
Kidney  50 
Milk  1.5 
Sheep  Muscle  50 
 
CAC/MRL 2-2011  
Australian standard 
MRL, 2012  Liver  50 
Kidney  50 
Milk  1.5 
Goat  Muscle  50 
 
CAC/MRL 2 -2011  
Australian standard 
MRL, 2012  
 Liver  50 
Kidney  50 
Milk  1.5 
Camel  
 
 
 Muscle  50  
CAC/MRL 2 -2011  
 
Australian standard 
MRL, 2012  Liver  50 
Kidney  50 
Milk  1.5 
Chicken  Muscle  50  
 
CAC/MRL 2 -2011  
 Liver  50 
Kidney  50 
6.1.5. CHLORAMPHENICOLS  
6.1.5.1 . Thiamphenicol * 
Acceptable Daily Intake (ADI)  
0-1 ug/kg  
body weight  
* banned by the Food and Drug Cattle  Muscle  50  
 
COMMISSION 
REGULATION (EU) No 
37/2010  
 
 
 Liver  50 
Kidney  50 
Fat 50 
Milk 50 17 
 Administration (FDA) in 1997  (µg/l)   
 
 
 
 
 
 
 
 
 
 
 
COMMISSION 
REGULATION (EU) No 
37/2010  Sheep  
 
 
 
 
 Muscle  50 
Liver  50 
Kidney  50 
Fat 50 
Milk 
(µg/l)  50 
Goat  
 
 Muscle  50 
Liver  50 
Kidney  50 
Fat 50 
Milk 
(µg/l)  50 
6.1.5.2 . Florfenicol *  
Acceptable Daily Intake (ADI)  
0-1 ug/kg  
body weight  
 
* banned by the Food and Drug 
Administration (FDA) in 1997  Cattle  Muscle  200 Canadian MRL  (2011)  
Liver  2000  
Kidney  500 Australian standard 
MRL, 2012  
Fish Muscle  500 Australian standard 
MRL, 2012  
6.1.6. DIAMINOPYRIMIDINES  
6.1.6.1. Trimethoprim  
Acceptable Daily Intake (ADI)  
20 ug/kg  
body weight  
 
 
 
 
 Cattle  Muscle  50  
 
Australian standard 
MRL, 2012  Liver  50 
Kidney  50 
Fat 50 
Milk 
(µg/l)  50 
Sheep  Muscle  50  
 
 
 Liver  50 
Kidney  50 18 
  
 
 
 
 
 
 
 
 
 
 
 
 
 Fat 50 Australian standard 
MRL, 2012  
Milk 
(µg/l)  50 
Goat  Muscle  50  
 
Australian standard 
MRL, 2012  Liver  50 
Kidney  50 
Fat 50 
Milk 
(µg/l)  50 
Camel  
 
 
 
 
 Muscle  50  
Australian standard 
MRL, 2012  
 
 
 
Australian standard 
MRL, 2012  
 Liver  50 
Kidney  50 
Fat 50 
Milk 
(µg/l)  
 50 
Chicken  Muscle  50 
Liver  50 
Kidney  50 
Fat /skin  50 
Fish Muscle  10 Canadian MRL(2011)  
6.1.7. FLUOROQUINOLONES  
6.1.7.1 . Danofloxacin  
Acceptable Daily Intake (ADI)  
0-20 μg/kg  
body weight   
Cattle   
Muscle   
70  
Canadian MRL, 2011  
Liver  70 
Kidney  400  
CAC/MRL 2 -2011  
 Fat  100 
 Muscle  200  
 
Liver  400 19 
 Chicken  Kidney  400 CAC/MRL 2 -2011  
 
Fat/Skin  100 
6.1.7.2 . Difloxacin  
Acceptable Daily Intake (ADI)  
10 ug/kg 
body weight  Cattle  Muscle  400  
 
 
 
 
 
 
 
COMMISSION 
REGULATION (EU) No 
37/2010  Liver  1400  
Kidney  800 
Fat  100 
Sheep  Muscle  400 
Liver  1400  
Kidney  800 
Fat  100 
Goat  Muscle  400 
Liver  1400  
Kidney  800 
Fat  100 
Poultry  Muscle  300 
Liver  1900  
Kidney  600 
Fat/skin   400 
6.1.7 .3. Enrofloxacin  
Acceptable Daily Intake (ADI)  
2 ug/kg 
body weight  Cattle  
 Muscle  100  
 
 
 
 
 
COMMISSION 
REGULATION (EU) No Liver  300 
Kidney  200 
Fat 100 
Milk 
(µg/l)  100 
 
Sheep  Muscle  100 
Liver  300 20 
 Kidney  200 37/2010  
Fat 100 
Milk 
(µg/l)  100 
Goat  Muscle  100  
 
 
 
 
COMMISSION 
REGULATION (EU) No 
37/2010  Liver  300 
Kidney  200 
Fat 100 
Milk 
(µg/l)  100 
Poultry  Muscle  100 
Liver  200 
Kidney  300 
Fat/skin  100 
Rabbit  Muscle  100 
Liver  200 
Kidney  300 
Fat 100 
6.1.7.4 . Flumequine  
Acceptable Daily Intake (ADI)  
0-30 μg/kg  
body weight  
 Cattle  Muscle  500  
 
CAC/MRL 2 -2011  
 Liver  500 
Kidney  3000  
Fat 1000  
Sheep  Muscle  500  
 
CAC/MRL 2 -2011  
 Liver  500 
Kidney  3000  
Fat 1000  
Chicken  Muscle  500  21 
  Liver  500  
CAC/MRL 2 -2011  
 Kidney  3000  
Fat /skin  1000  
Trout 
(Fish)  Muscle  500 CAC/MRL 2 -2011  
 
6.1.7.6. Marbofloxacin  
Acceptable Daily Intake (ADI)  
4.5 μg/kg  
body weight  Cattle  Muscle  150 EMEA/MRL/079/1996  
Liver  150 
Kidney  150 
Fat 50 
Milk  75 
6.1.7.7. Sarafloxacin  
Acceptable  Daily Intake (ADI)  
0-0.3 μg/kg  
body weight  
 Chicken  
 
 
 
 
 Muscle  10  
 
 
CAC/MRL 2 -2011  
 
 
 Liver  80 
Kidney  80 
Fat /skin  20 
Turkey  
 
 
 Muscle  10  
 
CAC/MRL 2 -2011  
 Liver  80 
Kidney  80 
Fat /skin  20 
6.1.8. LINCOSAMIDES  
6.1.8.1. Lincomycin  
 Acceptable Daily Intake (ADI)   
0 -30 μg/kg  
body weight  
 
 Cattle  Muscle  200  
 
Australian standard 
MRL, 2012  Liver  200 
Kidney  200 
Milk 
(µg/l)  20 
Goat  
 Muscle  200  
 
Australian standard 
MRL, 2012  
 Liver  200 
Kidney  200 22 
 Milk  100  
 
 
Camel  
 
 Muscle  200  
Australian standard 
MRL, 2012  Liver  200 
Kidney  200 
Chicken  
 Muscle  100 Canadian MRL  2011  
Liver  100 Australian standard 
MRL, 2012  Kidney  100 
Fat /skin  100 CAC/MRL 2 -2011  
Eggs  200 Australian standard 
MRL, 2012  
6.1.8.2 . Pirlymicin  
Acceptable Daily Intake (ADI)  
0 - 8 μg/kg  
body weight  
 Cattle  
 Muscle  100 CAC/MRL 2 -2011  
Liver  500 Canadian MRL  2011  
Kidney  400  
 
CAC/MRL 2 -2011  Fat 100 
Milk 
(µg/l)  100 
6.1.9. MACROLIDES  
6.1.9.1 . Erythromycin  
 Acceptable Daily Intake (ADI)  
0 - 0.7 μg/k g  
body weight  
 
  
Cattle  
 
 
 
 Muscle  100  
 
Canadian MRL  (2011)  Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l) 40 Australian standard 
MRL, 2012  
Sheep  Muscle  200  
 
Canadian MRL  (2011)  Liver  200 
Kidney  200 
Fat 200 23 
 Milk  
(µg/l) 40 Australian standard 
MRL, 2012  
Camel  Muscle  300  
 
Australian standard 
MRL, 2012  Liver  300 
Kidney  300 
Fat 300 
Milk 
(µg/l) 40 
 
Chicken  
 Muscle  100  
 
CAC/MRL 2 -2011  
 
 
 Liver  100 
Kidney  100 
Fat /skin  100 
Eggs  50 
 
Turkey  Muscle  100  
 
CAC/MRL 2 -2011  
 Liver  100 
Kidney  100 
Fat 100 
6.1.9.2. Oleandomycin  
Acceptable Daily Intake (ADI)  
0.00075 μg/k g  
body weight  
 
 
  
 Cattle  Muscle  100  
 
 
 
 
 
 
 
 
Australian standard 
MRL, 2012  
 
 
 
 Liver  100 
Kidney  100 
Sheep  Muscle  100 
Liver  100 
Kidney  100 
Goat  
 Muscle  100 
Liver  100 
Kidney  100 24 
 Camel  
 Muscle  100  
 
 
 
 Liver  100 
Kidney  100 
Chicken  Muscle  1000   
 
 
 
Canadian MRL  (2011)  
 Liver  1000  
Kidney  1000  
Fat /skin  1000  
Turkey  Muscle  1000  
Liver  1000  
Kidney  1000  
Fat 1000  
6.1.9.3. Spiramycin   
Acceptable Daily Intake (ADI)  
0 - 50 μg/kg  
body weight  
 Cattle  
 
 
 
 
 
 
 
 Muscle  200  
 
 
 
CAC/MRL 2 -2011  
 Liver  600 
Kidney  300 
Fat 300 
Milk 
(µg/l)  200 
Chicken  Muscle  200 
Liver  600 
Kidney  800 
Fat /skin  300 
6.1.9.4. Tilmicosin  
 Acceptable Daily Intake (ADI)  
0 - 40 μg/kg  
body weight   
Cattle  
 
 Muscle  50 Australian standard 
MRL, 2012  
Liver  1000   
CAC/MRL 2 -2011  
Kidney  300 
Fat 100 25 
 Milk 
(µg/l)  25 Australian standard 
MRL, 2012  
 
Sheep  Muscle  100  
CAC/MRL 2 -2011  
Liver  1000  
Kidney  300 
Fat 100 
 
Chicken  
 Muscle  150  
CAC/MRL 2 -2011  
Liver  2400  
Kidney  600 
Fat /skin  250 
 
 
Turkey  
 Muscle  100  
CAC/MRL 2 -2011  
Kidney  1200  
Liver  1400  
Fat /skin  250 
6.1.9.5. Tulathromycin  
Acceptable Daily Intake (ADI)  
0.005 mg/kg  
body weight  Cattle  
 Muscle  100 Australian standard 
MRL, 2012  
Liver  2000  Canadian MRL  2011  
Kidney  1000  Australian standard 
MRL, 2012  
Fat 100 
6.1.9.6 . Tylosin  
Acceptable Daily Intake (ADI)  
0 - 30 μg/kg  
body weight  
 Cattle  
 Muscle  100  
 
CAC MRL, 32nd (2009)  
 
 
Australian standard 
MRL, 2012  Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l)  50 
Chicken  
 Muscle  200  
 
Liver  200 26 
  Kidney  200  
 
Australian standard 
MRL, 2012  Fat /skin  100 
Turkey  Muscle  200 
Liver  200 
Kidney  200 
Fat /skin  100 
6.1.10. ORTHOSOMYCIN  
6.1.10.1. Avilamycin  
Acceptable Daily Intake (ADI)  
0.002  ug/kg 
body weight  
  
Chicken  Muscle  50  
 
Australian standard 
MRL, 2012  Liver  50 
Kidney  50 
Fat/skin  50 
 
Turkey  Muscle  50  
 
Australian standard 
MRL, 2012  Liver  50 
Kidney  50 
Fat 50 
 
Rabbit  Muscle  50  
 
Australian standard 
MRL, 2012  Liver  50 
Kidney  50 
Fat 50 
6.1.1 1. Pleuromutilin  
6.1.1 1.1. Tiamulin  
Acceptable Daily Intake (ADI)  
30 μg/kg  
body weight  Chicken  Muscle  100  
 
 
 
COMMISSION 
REGULATION (EU) No 
37/2010  
 Liver  1000  
Fat/skin  100 
Eggs  1000  
Turkey  Muscle  100 
Liver  300 
Fat/skin  100 
Rabbit  Muscle  100 
Liver  500 27 
 6.1.12. POLYPEPTIDES  
6.1.12.1. Bacitracin  
Acceptable Daily Intake (ADI)  
0-1 mg/kg  
body weight  
 Camel  Milk(μg/l)  500  
Australian standard 
MRL, 2012  
Canadian MRL, 2011   
 
Chicken  
 Muscle  500 
Liver  500 
Kidney  500 
Fat 500 
Eggs  500 
 
Turkey  
 Muscle  500  
Canadian MRL, 2011  
 Liver  500 
Kidney  500 
Fat 500 
6.1.12. 2. Colistin  
Acceptable Daily Intake (ADI)  
0-7 μg/kg  
body weight  
 
 
 
 
 
 
 
 
 
 
 
  
Cattle  Muscle  150  
 
 
CAC/MRL 2 -2011  
 Liver  150 
Kidney  200 
Fat  150 
Milk 
(µg/l)  50 
 
Sheep  Muscle  150  
 
CAC/MRL 2 -2011  
 Liver  150 
Kidney  200 
Fat  150 
Milk 
(µg/l)  50 
Goat  Muscle  150  
 
CAC/MRL 2 -2011  
 Liver  150 
Kidney  200 
Fat  150 28 
  
 
 
 
 
 
 
 
 
 
 
 
 Chicken  
 
 Muscle  150  
 
CAC/MRL 2 -2011  
 Liver  150 
Kidney  200 
Fat/skin  150 
eggs 300 
Turkey  Muscle  150  
CAC/MRL 2 -2011  
 Liver  150 
Kidney  200 
Fat/skin  150 
Rabbit  
 Muscle  150  
 
CAC/MRL 2 -2011  
 
 Liver  150 
Kidney  200 
Fat/skin  150 
6.1.12.3 . Polymixin B  
Acceptable Daily Intake (ADI)  
4.0 u/ml   Cattle  Milk 
(µg/l)  4000 
U/ml  Canadian MRL(2011)  
6.1.13. STREPTOGRAMINS  
6.1.13.1 . Virginiamycin  
Acceptable Daily Intake (ADI)  
250 μg/kg  
body weight  Cattle  Muscle  100  
 
Australian standard 
MRL, 2012  
 Liver  200 
Kidney  200 
Fat 200 
Milk 
(µg/l)  100 
 
Chicken  Muscle  200  
 
Australian standard 
MRL, 2012  
 Liver  200 
Kidney  200 
Fat /skin  200 
Eggs  100 29 
 6.1.14. SULFONAMIDES*  
* Extra -Label Use of Sulfonamides 
in Lactating Dairy Cattle Prohibited  
by US FDA (2005).  
6.1.1 4.1. Sulfabenzamide * 
Acceptable Daily Intake (ADI)  
0-50 μg/kg  
body weight  
 
*banned by US FDA, Canada and 
EC.  
 
Cattle  
 
 
 Muscle  100  
 
 
 
 
 
 
Canadian MRL  2011  
 
 
 
 
 
 Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l)  10 
Sheep  
 
 
 Muscle  100 
Liver  100 
Kidney  100 
Fat 100 
milk 10 
 
 
Goat  Muscle  100  
 
 
 
 
COUNCIL 
REGULATION (EEC) 
No 2377/90  Liver  100 
Kidney  100 
Fat 100 
milk 100 
 
 
Camel  Muscle  100 
Liver  100 
Kidney  100 
Fat 100 
milk 100 
6.1.14.2.  Sulfacetamide * 
Acceptable Daily Intake (ADI)  
2.5 mg/kg   
body weight  
 
*banned by US FDA, Canada and Cattle  
 
 
 Muscle  100  
 
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l)  10 30 
 EC. 
 
 
Sheep  Muscle  100  
 
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 
Milk  
(µg/l)  10 
6.1.14.3. Sulfachlorpyridazine * 
Acceptable Daily Intake (ADI)  
0.05 mg/kg  
body weight  
*banned by US FDA, Canada and 
EC.  
Cattle  
 Muscle  100  
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 
6.1.14.4. Sulfadiazine * 
Acceptable Daily Intake (ADI)  
0.02 mg/kg  
body weight  
 
*banned by US FDA, Canada and 
EC.  
Cattle  
 Liver  100  
Canadian MRL  2011  
 Kidney  100 
Fat 100 
Milk 
(µg/l)  100 Australian standard 
MRL, 2012  
 
Sheep  Muscle  100  
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 
 
Goat  Muscle  100  
Australian standard 
MRL, 2012  
 Liver  100 
Kidney  100 
Fat 100 
Camel  
 Muscle  100  
Australian standard 
MRL, 2012  
 Liver  100 
Kidney  100 31 
 Fat 100 
 
Chicken  
 Muscle  100  
Australian standard 
MRL, 2012  
 Liver  100 
Kidney  100 
Fat /skin  100 
Eggs  20 
6.1.14.5. Sulfadimethoxine * 
Acceptable Daily Intake (ADI)  
0.2 mg/kg  
body weight  
 
*banned  by US FDA, Canada and 
EC. Cattle  Muscle  100  
 
 
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l)  10 
Chicken  
 Muscle  100  
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat /skin  100 
 
Turkey  Muscle  100  
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat /skin  100 
6.1.14.6 . Sulfadimidine *       
(Sulfamethazine)                     
Acceptable Daily Intake (ADI)  
0.02 mg/kg 
body weight  
 
*banned by US FDA, Canada and  
Cattle  Muscle  100  
 
CAC/MRL 2 -2011  
 Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l)  25 32 
 EC. 
 
Sheep  Muscle  100  
 
 
 
 
 
COUNCIL 
REGULATION (EEC) 
No. 2377/90  
 
 
 
 
 
 
 
 
 
 
 
 
 
Australian standard 
MRL, 2012  
 Liver  100 
Kidney  100 
Fat 100 
milk 100 
 
Goat  Muscle  100 
Liver  100 
Kidney  100 
Fat 100 
milk 100 
 
Camel  Muscle  100 
Liver  100 
Kidney  100 
Fat 100 
milk 100 
 
Chicken  Muscle  100 
Liver  100 
Kidney  100 
Fat /skin  100 
 
Turkey  Liver  200 
Kidney  200 
Fat /skin  200 
6.1.14.7. Sulfadoxine * 
Acceptable Daily Intake (ADI)  
0.05 mg/kg  
body weight  
*banned by US FDA, Canada and Cattle  Muscle  100  
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 33 
 EC. Milk 
(µg/l)  10 
 
Sheep  Muscle  100  
 
 
 
Australian standard 
MRL, 2012  
 Liver  100 
Kidney  100 
Fat 100 
 
 
Goat  
 Muscle  100 
Liver  100 
Kidney  100 
Fat 100 
 
Camel  Muscle  100  
 
Australian standard 
MRL, 2012  
 Liver  100 
Kidney  100 
Fat 100 
6.1.14.8. Sulfaethoxypyridazine *  
Acceptable Daily Intake (ADI)  
0.01 mg/kg  
body weight  
 
*banned by US FDA, Canada and 
EC. Cattle  
 Muscle  100  
 
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 
Milk µg/l)  10 
6.1.14.9 . Sulfaguanidine * 
Acceptable Daily Intake (ADI)  
0.01 mg/kg  
body weight  
 
*banned by US FDA, Canada and 
EC. Cattle  
 Muscle  100  
 
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 
Milk µg/l)  10 
Sheep  Muscle  100  
 
 Liver  100 34 
 Kidney  100 Canadian MRL  2011  
 
Fat 100 
Rabbit  Edible 
offal  100  
 
 
Canadian MRL  2011  
 Muscle  100 
Liver  100 
Kidney  100 
6.1.14.10. Sulfamerazine * 
 
Acceptable Daily Intake (ADI)  
0–50 μg/kg  
body weight  
 
*banned by US FDA, Canada and 
EC. 
  
 
 
 
 
 
 
 
 
 
 
 
 Cattle  Muscle  100  
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 
Milk µg/l)  10 
Sheep  
 
 
 Muscle  100  
 
 
 
 
 
Canadian MRL  2011  
 
 
 
 
 
 Liver  100 
Kidney  100 
Fat 100 
Goat  Muscle  100 
Liver  100 
Kidney  100 
Fat 100 
Chicken  Muscle  100  
 
 
 
 
Canadian MRL  2011  
 
 Liver  100 
Kidney  100 
Fat /skin  100 
Eggs  100 
 Muscle  100 35 
  Turkey  Liver  100 
Kidney  100 
Fat /skin  100 
6.1.14.11. Sulfanilamide * 
 
Acceptable Daily Intake (ADI)  
75 ug/kg  
body weight  
 
*banned by US FDA, Canada and 
EC. Cattle  
 Muscle  100  
 
 
Canadian MRL  2011  
 
 Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l)  10 
Sheep  Muscle  100  
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 
Milk  
(µg/l)  10 
6.1.14.12. Sulfanitran * 
 
Acceptable Daily Intake (ADI)  
0.85 mg/kg  
body weight  
 
*banned by US FDA, Canada and 
EC. Chicken  Muscle  100  
 
 
 
 
 
 
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat /skin  100 
Eggs  100 
Turkey  
 
 Muscle  100 
Liver  100 
Kidney  100 
Fat /skin  100 
6.1.14. 13. Sulfapyridine *  
Acceptable Daily Intake (ADI)  
0.003 mg kg  Cattle  
 
 Muscle  100  
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 36 
 body weight  
*banned by US FDA, Canada and 
EC. Fat 100 
Milk 
(µg/l)  10 
6.1.14. 14. Sulfaquinoxaline * 
Acceptable Daily Intake (ADI)  
0.01 mg/kg  
body weight  
 
*banned by US FDA, Canada and 
EC. Cattle  Muscle  100  
 
 
 
 
Canadian MRL  2011  
 
 
 
 
 Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l)  10 
Sheep  Muscle  100 
Liver  100 
Kidney  100 
Fat 100 
Chicken  Muscle  100  
 
 
Australian standard 
MRL, 2012  Liver  100 
Kidney  100 
Fat /skin  100 
Eggs  10 
Turkey  
 
 Muscle  100  
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat /skin  100 
Rabbit  
 Muscle  100  
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 37 
 6.1.14. 15. Sulfathiazole * 
Acceptable Daily  Intake (ADI)  
0.2 mg/kg  
body weight  
 
*banned by US FDA, Canada and 
EC. 
 
 
 
 
 
 
 
 
 
 
 Cattle  
 
 
 Muscle  100  
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l)  10 
Sheep  
 Muscle  100  
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 
Goat  Muscle  100  
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat 100 
Chicken  Muscle  100  
 
 
 
 
 
 
Canadian MRL  2011  
 Liver  100 
Kidney  100 
Fat /skin  100 
Eggs  100 
Turkey  
 Muscle  100 
Liver  100 
Kidney  100 
Fat /skin  100 
6.1.1 5. TETRACYCLINES  
6.1.1 5.1. Chlortetracycline  Cattle  Muscle  100  
 
Australian standard Liver  300 38 
         Acceptable Daily Intake (ADI)  
  0-3 μg/kg  
body weight  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 Kidney  600 MRL, 2012  
 
Milk  
(µg/l)  100 CAC/MRL 2 -2011  
 
Sheep  Muscle  200  
 
CAC/MRL 2 -2011  Liver  600 
Kidney  1200  
Milk  
(µg/l)  100 
Chicken  
 Muscle  100 Australian standard 
MRL, 2012  
 
Liver  600 CAC/MRL 2 -2011, 
Australian standard 
MRL, 2012  
Kidney  600  
Australian standard 
MRL, 2012  Eggs  200 
 
Turkey  Muscle  100 Australian standard 
MRL, 2012  
 
Liver  600 
 Canadian MRL, 2011, 
Australian standard 
MRL, 2012  
Kidney  600 Australian standard 
MRL, 2012  
 
Fish 
 Muscle  200 CAC/MRL 2 -2011  
 
6.1.15.2. Doxycycline  
Acceptable Daily Intake (ADI)  
  0-3 μg/kg   
body weight  
 
 Cattle  
 
 
 
 Muscle  100  
 
COMMISSION 
REGULATION (EU) No 
37/2010  
 Liver  300 
Kidney  600 
Poultry  
 Muscle  100 
Liver  300 
Kidney  600 39 
 Fat/skin  300 
6.1.15.3. Oxytetracycline  
Acceptable Daily Intake (ADI)  
  0-3 μg/kg   
body  weight  
 
 Cattle  
 Muscle  100  
Australian standard 
MRL, 2012  Liver  300 
Kidney  600 
Milk 
(µg/l)  100 Canadian MRL  2011  
 
Sheep  
 
 Muscle  100  
 
Australian standard 
MRL, 2012  
 
 
 Liver  300 
Kidney  600 
Milk 
(µg/l)  100 
 
Goat  Muscle  100  
Australian standard 
MRL, 2012  Liver  300 
Kidney  600 
Milk 
(µg/l)  100 
Camel  Muscle  100  
Australian standard 
MRL, 2012  milk 100 
 
Chicken  
 Muscle  100 Australian standard 
MRL, 2012  
Liver  600  
Canadian MRL  2011  
Kidney  1200  
Eggs  400 
Turkey  Muscle  200  
Canadian MRL 2011  Liver  600 
Kidney  1200  
Salmonids 
Lobsters  Muscle  200 Canadian MRL 2011  
Skin 200 40 
 6.1.1 5.4. Tetracycline  
Acceptable Daily Intake (ADI)  
  0-3 μg/kg   
body weight  Cattle  
 Muscle  100  
 
 
 
COMMISSION 
REGULATION (EU) No 
37/2010  
 
 
 
 
 
 
 
COMMISSION 
REGULATION (EU) No 
37/2010  
 Liver  300 
Kidney  600 
Milk 
(µg/l)  100 
Sheep  
 
 Muscle  100 
Liver  300 
Kidney  600 
Milk 
(µg/l)  100 
Goat  Muscle  100 
Liver  300 
Kidney  600 
Milk 
(µg/l)  100 
Chicken  Muscle  100 
Liver  300 
Kidney  600 
Milk 
(µg/l)  100 
Eggs  200 
 
 
 
 
 41 
 6.2.  MAXIMUM RESIDUE LIMITS  OF ANTIFUNGAL DRUGS  
 
Drug groups  Food commodity   
MRL g/kg 
  
References  
(MRL)  Species  Tissue 
or 
product  
6.2.1. Natamycin  
 
Acceptable Daily Intake (ADI)  
0.3 mg/kg  
body weight  Cattle  Edible 
tissues  Withdrawn  
(for topical 
use only)   
EMEA/MRL/342/98  
6.2.2. Nystatin  
 
Acceptable Daily Intake (ADI)  
Not established  
 Cattle  Edible 
tissues  Withdrawn  
(for topical 
use only)   
 
EMEA/MRL/CVMP/
151/99  Poultry  Edible 
tissues  Withdrawn  
(for topical 
use only  
 
 
6.3. MAXIMUM RESIDUE LIMITS  OF ANTIPARASITIC DRUGS  
6.3.1.  Maximum Residue Limits (MRLs) of Anticoccidial drugs  
 
Drug groups  Food commodity   
MRL 
g/kg 
  
References  
(MRL)  Species  Tissue or 
product  
 6.3.1.1. Amprolium  
 
Acceptable Daily Intake 
(ADI)  
100 u g/kg  
body weight  Cattle  Muscle  500  
 
Canadian MRL, 2011  Liver  500 
Kidney  500 
Fat 2000  
Chicken  Muscle  200  
 
EMEA/MRL/767/00 -
FINAL  (2001)  Liver  200 
Kidney  400 
Skin/fat  200 
Eggs  1000 
Turkey  Muscle  200  42 
 Liver  200  
EMEA/MRL/767/00 -
FINAL (2001)  Kidney  400 
Skin/fat  200 
6.3.1.2. Clazuril  
 
Acceptable Daily Intake 
(ADI)  
0.05 mg/kg   
body weight   
Pigeon   
No MRL 
required   
Not 
applicable   
COMMISSION 
REGULATION (EU) No 
37/2010  
6.3.1.3. Clopidol  
 
Acceptable Daily Intake 
(ADI)  
0.0025 mg/kg  
body weight  
 
 
 
 
 
 Cattle  Muscle  200  
The Japan Food 
Chemical Research 
Foundation,  
http://www.m5.ws001.sq
uarestart.ne.jp/foundation
/agrdtl.php?a_inq=20100  Liver  2000  
Kidney  3000  
Fat 200 
Milk 
(µg/l)  20 
Chicken  Muscle  5000   
Canadian MRL, 2011  Liver  15000  
Kidney  15000  
Turkey  Muscle  5000   
Canadian MRL, 2011  Liver  15000  
Kidney  15000  
6.3.1.4. Decoquinate  
 
Acceptable Daily Intake 
(ADI)  
0-7 μg/kg   
body weight  
 
 
 Cattle  Muscle  1000   
Canadian MRL, 2011  
 Liver  2000  
Kidney  2000  
Fat 2000  
Goat  Muscle  1000   
Canadian MRL, 2011  
 Liver  2000  
Kidney  2000  43 
  
 
 Fat 2000  
Chicken  
 Muscle  1000   
Canadian MRL, 2011  
 Liver  2000  
Kidney  2000  
Fat 2000  
6.3.1.5. Diclazuril  
 
Acceptable Daily Intake 
(ADI)  
0-30 μg/kg  
body weight  Sheep  Muscle  500  
CAC/MRL 2 -2012  
 Liver  3000  
Kidney  2000  
Fat 1000  
Poultry  Muscle  500  
CAC/MRL 2 -2012  Liver  3000  
Kidney  2000  
Fat/skin  1000  
Rabbit  Muscle  500  
CAC/MRL 2 -2012  Liver  3000  
Kidney  2000  
Fat 1000  
6.3.1.6. Dinitolmide   
(Zoalene)    
 
Acceptable Daily Intake 
(ADI)  
μg/kg   
body weight  
 
 
 Chicken  Muscle  3000   
Australian standard 
MRL, 2012  
Canadian MRL, 2011  Liver  6000  
Kidney  6000  
Fat /skin  2000  
Turkey  
 
 
 Muscle  3000   
Canadian MRL, 2011  
 Liver  3000  
Kidney  6000  
Fat 3000  
6.3.1.7. Ethopapate    Chicken  Muscle  40  44 
  
Acceptable Daily Intake 
(ADI)  
100 ug/kg  
body weight  
 Other 
poultry  Muscle  5000   
 
The Japan Food 
Chemical Research 
Foundation  
http://www.m5.ws001.sq
uarestart.ne.jp/foundation
/agrdtl.php?a_inq=10900  
 Other 
poultry  Fat 5000  
Chicken,  Liver  40 
Other 
poultry  liver 20000  
Chicken  kidney  40 
Other 
poultry  kidney  20000  
Chicken  edible 
offal  40 
Other 
poultry  edible 
offal  20000  
6.3.1.8. Halofuginone 
hydrobromide    
 
Acceptable Daily Intake 
(ADI)  
0.0003 mg/kg  
body weight  Cattle  
 
 Muscle  10  
Australian standard 
MRL, 2012  
Canadian MRL(2011)  Liver  30 
Kidney  30 
Fat 25 
Chicken  liver 100 
6.3.1.9. Lasalocid Sodium  
  
 
Acceptable Daily Intake 
(ADI)  
0.001 mg/kg  
body weight  
 
 
 
 Cattle  Muscle  50  
 
Australian standard 
MRL, 2012  
 Liver  700 
Kidney  700 
Fat 700 
Milk 
(µg/l)  10 
Sheep  Muscle  50  
Australian standard 
MRL, 2012  Liver  700 
Kidney  700 45 
  
 
 
 Fat 700  
Goat  
 Muscle  50  
Australian standard 
MRL, 2012  
 Liver  700 
Kidney  700 
Fat 700 
 
Camel  Muscle  50  
Australian standard 
MRL, 2012  
 Liver  700 
Kidney  700 
Fat 700 
Chicken  Muscle  100  
Australian standard 
MRL, 2012  
 Liver  400 
Kidney  400 
Fat /skin  350 Canadian 
MRL(2011)  
Eggs  50 Australian standard 
MRL, 2012  
6.3.1.10. Maduramicin 
ammonium  
  
Acceptable Daily Intake 
(ADI)  
0.001 mg/kg  
body weight  Chicken  
 Muscle  100  
Australian standard 
MRL, 2012  
 Liver  1000  
Kidney  1000  
Fat /skin  400 Canadian MRL(2011)  
6.3.1.11. Methyl 
benzoquate  
  
Acceptable Daily Intake 
(ADI)  
0.005 mg/kg  
body weight  Chicken  Muscle  100  
Australian 
standard MRL,  2012  Liver  100 
Kidney  100 
Fat /skin  200 Canadian MRL (2011)  
6.3.1.12. Monensin  
  
Acceptable Daily Intake 
(ADI)  Cattle  Muscle  10 
CAC/MRL 2 -2011  Liver  20 
Kidney  10 46 
 0–10 μg/kg  
body weight  
 
 
 
 
 
 
 
 
 
 
 
 
 
 Fat 50 Canadian MRL (2011)  
Milk 
(µg/l)  2 CAC/MRL 2 -2011  
Sheep  Muscle  5 Australian standard 
MRL, 2012  
Liver  20 
CAC/MRL 2 -2011  
Kidney  10 
Fat 70 Australian standard 
MRL, 2012  
Goat  Muscle  10  
CAC/MRL 2 -2011  
 Liver  20 
Kidney  10 
Fat 100 
Chicken  
 
 
 Muscle  10  
CAC/MRL 2 -2011  
 Liver  10 
Kidney  10 
Fat /skin  50 Canadian MRL (2011)  
6.3.1.13. Narasin  
  
Acceptable Daily Intake 
(ADI)  
0–5 μg/kg  
body weight  
 
 Cattle  
 
 Muscle  15  
JECFA/75/SC – 2012  
 
 Liver  50 
Kidney  15 
Fat 50 
Chicken  
 Muscle  15  
 
CAC MRL, 31th (2008)  Liver  50 
Kidney  15 
Fat /skin  50 
6.3.1.14. Nicarbazin  
  
Acceptable Daily Intake Chicken  
 
 Muscle  200  
 Liver  200 47 
 (ADI)  
0-400 μg/kg  
body weight   
 Kidney  200 CAC/MRL 2 -2012  
Fat /skin  200 
6.3.1.15. Ormetoprim  
  
Acceptable Daily Intake 
(ADI)  
4 ug/kg  
body weight  
  
Salmonids   
muscles   
100  
Canadian MRL(2011)  
skin 100 
6.3.1.16. Robenidine 
hydrochloride  
  
Acceptable Daily Intake 
(ADI)  
0.005 mg/kg  
body weight  Chicken  Muscle  100 Canadian MRL(2011)  
Australian standard 
MRL, 2012  Liver  100 
Kidney  100 
Fat /skin  200 Canadian MRL(2011)  
6.3.1.17. Salinomycin 
Sodium  
  
Acceptable Daily Intake 
(ADI)  
0.01 mg/kg  
body weight  
 
 
 
 
 
 
 
 Cattle  Muscle  50 Australian standard 
MRL, 2012  
Liver  350 Canadian MRL(2011)  
Kidney  500 Australian standard 
MRL, 2012  
Chicken  
 
 
 Muscle  100 
Australian standard 
MRL, 2012  Liver  500 
Kidney  500 
Fat /skin  350 Canadian MRL(2011)  
Eggs  20 Australian standard 
MRL, 2012  
6.3.1.18. Semduramicin  
  
Acceptable Daily Intake 
(ADI)  
3 ug/kg  
body weight  Chicken  
 Muscle  50 National Registration 
Authority  
for Agricultural and 
Veterinary Chemicals, 
Australia, 2001  Liver  500 
Kidney  200 
Fat /skin  500 
6.3.1.19. Toltrazuril  Cattle  Muscle  250 Australian standard 48 
   
Acceptable Daily Intake 
(ADI)  
2 ug/kg  
body weight  Liver  2000  MRL, 2012  
Kidney  1000  
Fat 1000  
Chicken  Muscle  2000   
Australian standard 
MRL, 2012  Liver  5000  
Kidney  5000  
Eggs  30 
 
 
 
6.3.2.  Maximum Residue Limits (MRLs) of Anthelmintic agents  
 
Drug groups  Food commodity   
MRL 
g/kg 
  
References  
(MRL)  Species  Tissue 
or 
product  
6.3.2.1. Abamectin  
 
Acceptable Daily Intake (ADI)  
0-2 µg/kg  
body weight  
 
 
 
 
 
 
 
 
 
 
 
 
 
  
Cattle  Muscle  5 Australian standard 
MRL, 2011  
Liver  100 
CAC/MRL 2 -2011  
 Kidney  50 
Fat 100 
Milk  20 Australian standard 
MRL, 2012  
 
Sheep  Muscle  20 EMEA/MRL/865/03 -
FINAL June 2004  
Liver  50 Australian standard 
MRL, 2012  
 Kidney  50 
Fat 50 
 Meat  10  49 
  
 
 
 
 
 
 
  Goat  Liver  50  
Australian standard 
MRL, 2012  
 Kidney  10 
Fat 100 
Milk  5 
 
Chicken  Meat  10  
The Japan Food 
Chemical Research 
Foundation, 2012  
 
 Liver  20 
Kidney  20 
Fat/skin  10 
Eggs  10 
 
6.3.2.2. Albendazole  
 
Acceptable Daily Intake (ADI)  
0 - 50 μg/kg  
 body weight  
 
 
 
 
 
 
 
 
 
 
 
 Cattle  Muscle  50 Canadian MRL 2011  
Liver  100 Australian standard 
MRL, 2012  
Kidney  50 letter cl 2005 -10 rvdf  
Fat 100 Canadian MRL 2011  
Milk 
(µg/l)  100 CAC/MRL 2 -2011  
Sheep  Muscle  100  
 
EMEA/MRL/865/03 - 
June 2004  
 Liver  1000  
Kidney  500 
Fat 100 
Milk  100 
 
Goat  
 Muscle  100  
 
Australian standard 
MRL, 2012  Liver  100 
Kidney  100 
Fat 100 
Milk  100 50 
  
 Camel  Muscle  100  
 
EMEA/MRL/865/03 - 
June 2004  
 Liver  1000  
Kidney  500 
Fat 100 
Milk 
(μg/l)  100 
6.3.2.3. Avermectin  
 
Acceptable Daily Intake (ADI)  
0 -2 μg/kg  
 body weight  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 Cattle  
 
 Muscle  5 Australian standard 
MRL, 2012  
Liver  100  
CAC/MRL 2 -2011  Kidney  50 
Fat 100 
Milk 
(µg/l)  20 Australian standard 
MRL, 2012  
 
 
Sheep  Muscle  20 EMEA/MRL/865/03 -
FINAL June 2004  
Liver  50  
Australian standard 
MRL, 2012  Kidney  50 
Fat 50 
 
 
Goat  Muscle  10  
 
Australian standard 
MRL, 2012  Liver  50 
Kidney  10 
Fat 100 
Milk  5 
Chicken  
 
 
 Meat  10 The Japan Food 
Chemical Research 
Foundation  
http://www.m5.ws001.s
quarestart.ne.jp/foundat
ion/agrdtl.php?a_inq=3Liver  20 
Kidney  20 
Fat/skin  10 51 
  Eggs  10 900 
 6.3.2.4. Closantel  
Acceptable Daily Intake (ADI)  
0 - 30 μg/kg  
 body weight  
 
 
 
 
 
 Cattle  Muscle  1000   
 
CAC/MRL 2 -2011  Liver  1000  
Kidney  3000  
Fat 3000  
 
Milk 
(µg/l)  45 European commission,  
http://www.vmd.defra.g
ov.uk/pdf/MRLMilk_ar
ticle.pdf  
Sheep  
 Muscle  1500   
CAC/MRL 2 -2011  Liver  1500  
Kidney  3000  CIRCULAR LETTER 
CL 2005 -10 RVDF  
Fat 2000  CAC/MRL 2 -2011  
 
milk  
45 European commission,  
http://www.vmd.defra.g
ov.uk/pdf/MRLMilk_ar
ticle.pdf  
 6.3.2.5. Derquantel   
 
Acceptable Daily Intake (ADI)  
0 – 0.3 μg/kg  
 body weight  
  
Sheep  Muscle  0.2  
 
JECFA/75/SC - 2012  Liver  2.0 
Kidney  0.2 
Fat 0.7 
6.3.2.6. Doramectin    
 
Acceptable Daily Intake (ADI)  
0 -1 μg/kg  
body weight  
 
 
  
Cattle  Muscle  10 CAC/MRL 2 -2011  
Liver  70 Canadian MRL, 2011  
Kidney  30 CAC/MRL 2 -2011  
Fat 100 Australian standard 
MRL, 2012  
Milk 
(µg/l)  15 CAC/MRL 2 -2011  52 
  
  
Sheep  Muscle  20  
Australian standard 
MRL, 2012  Liver  50 
Kidney  50 
Fat 100 
6.3.2.7. Eprinomectin  
 
Acceptable Daily Intake (ADI)  
0 - 10 μg/kg  
body weight  
 Cattle  
 
 Muscle  50 CODEX CIRCULAR 
LETTER CL 2005 -10 
RVDF  
Liver  1000  Canadian MRL(2011)  
Kidney  300 
CAC/MRL 2 -2011  Fat 250 
Milk 
(µg/l)  20 
6.3.2.8. Febantel/Fenbendazole  
 
Acceptable Daily Intake (ADI)  
0-4 μg/kg  
body weight  
 
 
 
 
 
 
 
 
 
 
 Cattle  Muscle  50 CIRCULAR LETTER 
CL 2005 -10 RVDF  
Liver  100 Australian standard 
MRL, 2012  
Kidney  50 CIRCULAR LETTER 
CL 2005 -10 RVDF  
Fat 50 
Milk 
(µg/l)  10  
Sheep  Muscle  100  
 
CAC/MRL 2 -2011  Liver  500 
Kidney  100 
Fat 100 
milk 100 
Goat  
 Muscle  50 CIRCULAR LETTER 
CL 2005 -10 RVDF  
Liver  500 CAC/MRL 2 -2011  
Kidney  50 CODEX CIRCULAR 53 
 Fat 50 LETTER CL 2005 -10 
RVDF  
milk 100 CAC/MRL 2 -2011  
6.3.2.9. Flubendazole    
Acceptable Daily Intake (ADI)  
0-12 µg/kg  
body weight  Chicken  
 
 
 Muscle  50 CODEX CIRCULAR 
LETTER CL 2005 -10 
RVDF  
CAC/MRL 2 -2011  Liver  400 
eggs 400 
6.3.2.10. Ivermectin    
 
Acceptable Daily Intake (ADI)  
0 - 1 μg/kg  
body weight  
 
 
 
 
 
  
Cattle  
 Muscle  10  
Canadian MRL(2011)  
Liver  70 
Kidney  10 Australian standard 
MRL, 2012  
Fat 100 Canadian MRL(2011)  
Milk 
(µg/l)  10 CAC/MRL 2 -2011  
CODEX CIRCULAR 
LETTER CL 2005 -10 
RVDF  
 
 
Sheep  Muscle  10 Canadian MRL(2011)  
Liver  15 CAC/MRL 2 -2011  
Kidney  10 Australian standard 
MRL, 2012  
Fat 20 CAC/MRL 2 -2011  
6.3.2.11. Levamisole    
 
Acceptable Daily Intake (ADI)  
3 ug/kg 
body weight  
 
 
 
 Cattle  
 
 
 Muscle  10 CAC/MRL 2 -2011  
Liver  100 CAC/MRL 2 -2011  
Canadian MRL(2011)  
Kidney  10 CAC/MRL 2 -2011  
Fat 10 CAC/MRL 2 -2011  
Sheep  Muscle  10  
CAC/MRL 2 -2011  Liver  100 54 
  
 
 
 
 
 
 
 
 
 
 
  Kidney  10  
 Fat 10 
Milk  300 Australian standard 
MRL, 2012  
Goat  
 
 Muscle  100  
 
Australian standard 
MRL, 2012  Liver  1000 
Kidney  1000 
Milk  100 
Camel  Muscle  100  
 
Australian standard 
MRL, 2012  Liver  1000  
Kidney  1000  
Milk  300 
Chicken  
 Muscle  10 CAC/MRL 2 -2011  
Liver  100  
CAC/MRL 2 -2011  Kidney  10 
Fat 
/skin  10 
Eggs  1000  Australian standard 
MRL, 2012  
6.3.2.12. Mebendazol  
Acceptable Daily Intake (ADI)  
1.25 μg/kg  
body weight  
 Sheep  
 Muscle  60  
EMEA/MRL/ 781/01-
FINAL ( 2001 ) Liver  400 
Kidney  60 
Fat 60 
Goat  Muscle  60  
EMEA/MRL/ 781/01-
FINAL ( 2001 ) Liver  400 
Kidney  60 
Fat 60 55 
 6.3.2.1 3. Monepantel    
Acceptable Daily Intake (ADI)  
0–20 μg/kg  
body weight  
 
 
 
 
 Cattle  Liver  1500   
Canadian MRL(2011)  Milk 
(µg/l)  100 
Goat  Milk  100 Australian standard 
MRL, 2012  
Sheep  
 
 Muscle  300 (JECFA/75/SC – 2012)  
Liver  2000  Australian standard 
MRL, 2012  
Kidney  700  
JECFA/75/SC – 2012  Fat 5500  
Milk  100 Australian standard 
MRL, 2012  
Camel  Milk  100 Australian standard 
MRL, 2012  
6.3.2.1 4. Moxidectin    
Acceptable Daily Intake (ADI)  
0-2 μg/kg  
body weight  
 
 Cattle  
 
 Muscle  50 Canadian MRL(2011)  
CODEX CIRCULAR 
LETTER CL 2005 -10 
RVDF  
Liver  100  
CAC/MRL 2 -2011  Kidney  50 
Fat 500 
Milk 
(µg/l)  40 
 Canadian MRL(2011) 
CODEX CIRCULAR 
LETTER CL 2005 -10 
RVDF  
Sheep  Muscle  50 CAC/MRL 2 -2011  
Liver  50 Australian standard 
MRL, 2012  
Kidney  50  56 
 Fat 500 CAC/MRL 2 -2011  
6.3.2.1 5. Nitobimin  
Acceptable Daily Intake (ADI)  
5 ug/kg  
body weight  
 Cattle  
 
 Muscle  100  
EMEA/MRL/ 565/99-
FINAL  (1999)  Liver  1000  
Kidney  500 
Fat 100 
Milk 
(µg/l)  100 
Sheep  Muscle  100  
EMEA/MRL/ 565/99-
FINAL (1999)  Liver  1000  
Kidney  500 
Fat 100 
Milk 
(µg/l)  100 
Goat  Muscle  100  
EMEA/MRL/ 565/99-
FINAL (1999)  Liver  1000  
Kidney  500 
Fat 100 
Milk 
(µg/l)  100 
6.3.2.1 6. Nitroxynil   
Acceptable Daily Intake (ADI)  
0-20 (μg/Kg)   
body weight     
 
 
 
 Cattle  Muscle  1000   
Australian standard 
MRL, 2012  Liver  1000  
Kidney  1000  
Fat 1000  
Goat  
 Muscle  1000   
Australian standard 
MRL, 2012  Liver  1000  
Kidney  1000  
Fat 1000  57 
  Sheep  
 Muscle  1000   
Australian standard 
MRL, 2012  Liver  1000  
Kidney  1000  
Fat 1000  
6.3.2.1 7. Oxfendazole    
Acceptable Daily Intake (ADI)  
0-20 μg/Kg   
body weight  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 Cattle  Muscle  50  
 
 
 
 
CR-2377_99  Liver  500 
Kidney  50 
Fat 50 
Milk 
(µg/l)  10 
Goat  Muscle  50 
Liver  500 
Kidney  50 
Fat 50 
Milk 
(µg/l)  10 
Sheep  
 Muscle  50 
Liver  500 
Kidney  50 
Fat 50 
Milk 
(µg/l)  10 
Camel  Muscle  50 
Liver  500 
Kidney  50 
Fat 50 
Milk 10 58 
 (µg/l)  
salmonids  muscles  100 Canadian MRL(2011)  
skin 100 
6.3.2.1 8. Oxyclozanide  
Acceptable Daily Intake (ADI)  
0.03 m g/Kg   
body weight  Cattle  Muscle  20  
EMEA/MRL/889/03 -
FINAL  (2004)  Liver  500 
Kidney  100 
Fat 20 
Milk 
(µg/l)  10 
Sheep  Muscle  20  
EMEA/MRL/889/03 -
FINAL  (2004)  Liver  500 
Kidney  100 
Fat 20 
6.3.2.1 9. Piperazine  
Acceptable Daily Intake (ADI)  
0.25 m g/Kg   
body weight   
Chicken   
eggs  
2 000   
COMMISSION 
REGULATION (EU) 
No 37/2010  
6.3.2. 20. Prazequantel    
Acceptable Daily Intake (ADI)  
0-20 μg/Kg   
body weight  
  
Sheep  Muscle  50  
Australian standard 
MRL, 2012  
 Liver  50 
Kidney  50 
Fat 50 
6.3.2. 21. Rafoxanide    
Acceptable Daily Intake (ADI)  
2 μg/Kg   
body weight  
  
Cattle  
 Muscle  30  
EMEA/MRL/636/99  
FINAL  (1999)  
 Liver  10 
Kidney  40 
Fat 30 
Sheep  Muscle  100 EMEA/MRL/636/99  
FINAL (1999)  
Liver  150 59 
 Kidney  150 
Fat 250 
6.3.2. 22. Thiabendazole   
 
Acceptable Daily Intake (ADI)  
0.3  mg/kg  
body weight  
 
 
 
 
 
 
 
 
 
 
 
 
 Cattle  Muscle  100  
CAC/MRL 2 -2011  Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l)  50 Australian standard 
MRL, 2012  
Goat  Muscle  100  
 
CAC/MRL 2 -2011  Liver  100 
Kidney  100 
Fat 100 
milk 
(µg/l)  50 Australian standard 
MRL, 2012  
Sheep  Muscle  100  
 
CAC/MRL 2 -2011  Liver  100 
Kidney  100 
Fat 100 
milk 50 Australian standard 
MRL, 2012  
Camel  milk 100 
6.3.2. 23. Triclabendazole    
Acceptable Daily  Intake (ADI)  
0-3 μg/kg   
body weight  
  
 Cattle  
 
 Muscle  250  
CAC/MRL 2 -2011  
  
 Liver  850 
Kidney  400 
Fat 100 
Milk 
(µg/l)  50 
Goat  Muscle  500  60 
 Liver  2000  Australian standard 
MRL, 2012  
Kidney  1000  
Fat 1000  
Sheep  Muscle  200  
 
CAC/MRL 2 -2011  Liver  300 
Kidney  200 
Fat 100 
Camel  Muscle  500  
 
Australian standard 
MRL, 2012  Liver  2000  
Kidney  1000  
Fat 1000  
 
 
6.3.3.  Maximum Residue Limits (MRLs) of Antiprotozoal drugs  
 
Drug groups  Food commodity   
MRL 
g/kg 
  
References  
(MRL)  Species  Tissue 
or 
product  
6. 3.3.1.  Diminazene  
Acceptable Daily Intake (ADI)  
0-100 μg/kg  
body weight  Cattle  
 Muscle  500  
CAC/MRL 2 -2011 Liver  12000  
Kidney  6000  
Milk 
(µg/l)  150 
6. 3.3.2.  Imidocarb  
Acceptable Daily Intake  (ADI)  
0-10 μg/kg  
body weight  Cattle  
 Muscle  300  
CAC/MRL 2 -2011 Liver  1500  
Kidney  2000  
Fat 50 
Milk 50 61 
 (µg/l)  
6. 3.3.3.  Isometamidium  
Acceptable Daily Intake (ADI)  
0-100 μg/kg  
body weight  Cattle  
 Muscle  100  
CAC/MRL 2 -2011 Liver  500 
Kidney  1000  
Fat 100 
Milk 
(µg/l)  100 
 
 
6.3.4.  Maximum Residue Limits (MRLs) of  Ectoparasiticides  
 
Drug groups  Food commodity   
MRL 
g/kg 
  
References  
(MRL)  Species  Tissue or 
product  
6. 3.4.1.  Amitraz  
Acceptable Daily Intake (ADI)  
0 -0.5µg/kg  
body weight  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 Cattle  Muscle  100 Australian standard 
MRL, 2012  
Liver  200  
 
COMMISSION 
REGULATION (EU) 
No 37/2010  Kidney  200 
Fat 200 
Milk 
(μg/l)  10 
Sheep  Meat  100 Australian standard 
MRL, 2012  
 
Liver  100  
COMMISSION 
REGULATION (EU) No 
37/201 0 Kidney  200 
Fat 400 
Milk 
(μg/l)  10 
Goat 
 Meat  100 Australian standard 
MRL, 2012  
Liver  100  
COMMISSION 
REGULATION (EU) No 
37/2010  Kidney  200 62 
  
 
 
 
 
 
 
 
 
 
 
 Fat 200 
Milk 
(μg/l)  10 
Camel  Muscle  100  
Australian standard 
MRL, 2012  Liver  500 
Kidney  500 
Fat 500 
Milk 
(μg/l)  100 
6. 3.4.2.  Cyfluthrin  
 
Acceptable Daily Intake (ADI)  
0-20 μg/kg  
body weight  
 
 
 
 
 
 
 
 
 
 
 
 
 
 Cattle  
 Muscle  20 CAC/MRL 2 -2011, 
Australian standard 
MRL, 2012  
 Liver  10 
Kidney  10 
Fat  200 
CAC/MRL 2 -2011  
Milk 
(µg/l)  40 
Sheep  Muscle  20  
 
Australian standard 
MRL, 2012  
 Liver  10 
Kidney  10 
Fat  500 
Milk 
(µg/l)  100 
Goat Muscle  20  
Australian standard 
MRL, 2012  
 Liver  10 
Kidney  10 
Fat  500 
Milk 
(µg/l)  100 
Camel  
 Muscle  20  
Australian standard 
MRL, 2012  Liver  10 
Kidney  10 63 
  
 
 
 
 
 
 
 
  
 Fat  500  
Milk 
(µg/l)  100 
Chicken  Muscle  10  
Australian standard 
MRL, 2012  
 Liver  10 
Kidney  10 
Fat/skin  10 
eggs 10 
Turkey  
 Muscle  10  
 Liver  10 
Kidney  10 
Fat/skin  10 
6.3.4.3.  Cyhalothrin  
 
Acceptable Daily Intake (ADI)  
0-5 μg/kg  
body weight  
 
 
 
 
 
 
 
 
 
 
 Cattle  Muscle  20 CAC/MRL 2 -2011  
Australian standard 
MRL, 2012  Liver  20 
Kidney  20 
Fat  3000   
US Maximum Residue 
Levels in Food 
Commodities  Milk 
(µg/l)  200 
Sheep  Muscle  20 CAC/MRL 2 -2011  
Australian standard 
MRL, 2012  
Liver  20 Australian standard 
MRL, 2012  
Kidney  20 CAC/MRL 2 -2011  
Australian standard 
MRL, 2012  
Fat  400 CAC/MRL 2 -2011  
 
Goat 
 Muscle  
200 US Maximum Residue 
Levels in Food 
Commodities  
Liver  20 Australian standard 
MRL, 2012  
Kidney  20 64 
  
 
 
 
 
 
 
 
 
  
 Fat  3000  US Maximum Residue 
Levels in Food 
Commodities  milk 200 
Camel  Muscle  500  
Australian standard 
MRL, 2012  
 Liver  20 
Kidney  20 
Chicken  
 
 
 Muscle  20  
Australian standard 
MRL, 2012  
 
 Liver  20 
Kidney  20 
Fat/skin  20 
eggs 20 
6.3.4.4.  Cypermethrin  
Acceptable Daily Intake (ADI)  
0-20 μg/kg   
body weight  
 
 
 
 
 
 
 
 
 
 
 
 Cattle  
 Muscle  50 CAC/MRL 2 -2011  
Liver  50 CAC/MRL 2 -2011, 
Australian standard 
MRL, 2012  Kidney  50 
Fat  1000  
CAC/MRL 2 -2011  
Milk 
(µg/l)  100 
Sheep  Muscle  50 CAC/MRL 2 -2011  
Liver  50 CAC/MRL 2 -2011, 
Australian standard 
MRL, 2012  Kidney  50 
Fat  1000  CAC/MRL 2 -2011  
Goat Muscle  500  
Australian standard 
MRL, 2012  Liver  50 
Kidney  50 
Fat  50 
Chicken  eggs 50 Australian standard 
MRL, 2012  65 
 6.3.4.5.  Cyromazine  
 
Acceptable Daily Intake (ADI)  
0.06 mg/kg  
body weight  
 Sheep  Muscle  300 
COMMISSION  
REGULATION (EU) 
No 37/2010  Liver  300 
Kidney  300 
Fat  300 
6.3.4.6.  Deltamethrin  
Acceptable Daily Intake (ADI)  
0-10 μg/kg  
body weight  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 Cattle  
 
 
 
 
 Muscle  30 CAC/MRL 2 -2011  
Liver  50 
Kidney  50  
CAC/MRL 2 -2011  
Australian standard 
MRL, 2012  Fat 500 
Milk 
(µg/l)  30  
CAC/MRL 2 -2011  
Sheep  
 
 Muscle  30  
CAC/MRL 2 -2011  
 Liver  50 
Kidney  50 
Fat 200 Australian standard 
MRL, 2012  
Milk 
(µg/l)  50 
Goat Muscle  200 Australian standard 
MRL, 2012  
Liver  100 
Kidney  100 
Fat 200 
Milk 
(µg/l)  50 
Camel  Milk  50 Australian standard 
MRL, 2012  
 
Chicken  Muscle  10 Australian standard 
MRL, 2012  
 Liver  10 
Kidney  10 66 
  
  Fat /skin  500 CAC/MRL 2 -2011  
Eggs  10 Australian standard 
MRL, 2012  
 
Fish 
(salmon)  Muscles  
 30 
 CAC/MRL 2 -2011  
 
6.3.4.7. Diazinon * 
Acceptable Daily Intake (ADI)  
0–0.002 mg/kg  
body weight  
*banned by U.S. Environmental 
Protection Agency (EPA ), 2000  
 Cattle  
 
 
 Muscle  20  
 
 
 
 
 
 
 
 
 
COMMISSION 
REGULATION (EU) 
No 37/2010  Liver  20 
Kidney  20 
Fat 700 
Milk 
(µg/l)  20 
Sheep  Muscle  20 
Liver  20 
Kidney  20 
Fat 700 
Milk 
(µg/l)  20 
Goat  Muscle  20 
Liver  20 
Kidney  20 
Fat 700 
Milk 
(µg/l)  20 
6.3.4.8.  Dicyclanil  
Acceptable Daily Intake (ADI)  
0-7 μg/kg   
body weight  Sheep  
 Muscle  150  
CAC/MRL 2 -2011 
 
 Liver  125 
Kidney  125 
Fat 200 
6.3.4.9.  Emamectin  Cattle  Muscle  2  67 
 Acceptable Daily Intake (ADI)  
0.002 mg/kg  
body weight  
 
 
 
 
 
 
 
 
 
 
 
 
 
  Milk 
(µg/l)  0.5 Australian standard 
MRL, 2012  
 
Sheep  
 Muscle  2  
Australian standard 
MRL, 2012  
 Milk 
(µg/l)  0.5 
Goat 
 Muscle  2  
Australian standard 
MRL, 2012  
 Milk 
(µg/l)  0.5 
Camel  
 Muscle  2  
Australian standard 
MRL, 2012  
 Milk 
(µg/l)  0.5 
Salmonids  Muscle  100 Canadian MRL(2011)  
Skin 1000  
6.3.4.10.  Fluazuron  
 
Acceptable Daily Intake (ADI)  
0-40 μg/kg  
body weight  
 Cattle  
 Muscle  200  
CAC/MRL 2 -2011 Liver  500 
Kidney  500 
Fat 7000  
6.3.4.11.  Permethrin  
 
Acceptable Daily Intake (ADI)  
0.05 mg/kg  
body weight  
 
 
 Cattle  
 Muscle  50  
 
COMMISSION 
REGULATION (EU) 
No 37/2010  Liver  50 
Kidney  50 
Fat 500 
Milk 
(µg/l)  50 
6. 3.4.12.  Phoxim  
Acceptable Daily Intake (ADI)  
0.00025 mg/kg  Sheep  
 
 Muscle  50  
CAC/MRL 2 -2011  Liver  50 
Kidney  50 68 
 body weight  
 
 
 
  Fat 400  
 
Goat 
 
 Muscle  50  
CAC/MRL 2 -2011  
 Liver  50 
Kidney  50 
Fat 400 
6. 3.4.13.  Teflubenzuron  
Acceptable Daily Intake (ADI)  
0.01 mg/kg  
body weight  Salmonids  Muscle  300 Canadian MRL(2011)  
skin 320 
6. 3.4.14.  Trichlorfon 
(metrifonate)   
Acceptable Daily Intake (ADI)  
0-2 μg/kg  
body weight  Cattle  
 Muscle  100 Australian standard 
MRL, 2012  
 Liver  100 
Kidney  100 
Fat 100 
Milk 
(µg/l)  50 Canadian MRL(2011)  
 
 
6.4.  MAXIMUM RESIDUE LIMITS  OF ANTI -INFLAMMATORIES (AI)  
6.4.1.  Maximum Residue Limits (MRLs) of  Non  Steroidal AI  
 
Drug groups  Food commodity   
MRL 
g/kg 
  
References  
(MRL)  Species  Tissue 
or 
product  
6.4.1.1. Carprofen  
 
Acceptable Daily Intake (ADI)  
8.6 μg/kg  
body weight  Cattle  Muscle  500 COMMISSION 
REGULATION (EU) 
No 37/2010  
EMEA/MRL/042/95  Liver  1000  
Kidney  1000  
Fat 1000  
6.4.1.2. Diclofenac  Cattle  Muscle  5  69 
  
Acceptable Daily Intake (ADI)  
0.5 μg/kg  
body weight  Liver  5  
COMMISSION 
REGULATION (EU) 
No 37/2010  Kidney  10 
Fat 1 
Milk 
(µg/l)  0.1 
6.4.1.3. Flunixin meglumine  
Acceptable Daily Intake (ADI)  
0-6 µg/kg  
body weight  
 
 
 Cattle  
 
 
 
 
 Muscle  20 Australian standard 
MRL, 2012,  
Canadian MRL(2011)  
Liver  20 Australian standard 
MRL, 2012  
Kidney  20 
Fat 30  
COMMISSION 
REGULATION (EU) 
No 37/2010  
Milk 
(µg/l)  6 Canadian MRL(2011)  
6.4.1.4 . Ketoprofen  
Acceptable Daily Intake (ADI)  
0.001  mg/kg  
body weight  
 
 Cattle  
 
 
 
 Muscle  50  
Australian standard 
MRL, 2012,  
Canadian MRL(2011)  
 
 Liver  50 
Kidney  50 
Fat 50 
Milk 
(µg/l)  50 
Muscle  50 
6.4.1.5 . Meloxicam  
 
Acceptable Daily Intake (ADI)  
0.0001 mg/kg  
body weight  
 
 
 
 
 
 
 
 Cattle  
 
 
 
 
 
 Muscle  10 Australian standard 
MRL, 2012  
Liver  60 Canadian  MRL(2011)  
 Kidney  20 
Fat 0.02 USDA Foreign 
Agricultural Service  
Gain Report Number: 
JA7053,2007  
Milk 
(µg/l)  5 Australian standard 
MRL, 2012  70 
 6.4.1. 6. Tolfenamic acid  
 
Acceptable Daily Intake (ADI)  
0.01 mg/kg  
body weight  Cattle  
 Muscle  50  
EMEA/MRL/183/97  
FINAL  (1997)  
 Liver  400 
Kidney  100 
Milk 
(µg/l)  50 
 
 
6.4.2.  Maximum Residue Limits (MRLs) of  Steroidal AI  
 
Drug groups  Food commodity   
MRL 
g/kg 
  
References  
(MRL)  Species  Tissue 
or 
product  
6.4.2.1. Dexamethasone  
Acceptable Daily Intake (ADI)  
0-0.015 μg/kg  
body weight  Cattle  Muscle  1.0 
CAC/MRL 2 -2011  Liver  2.0 
Kidney  1.0 
Fat 0.3 Australian standard 
MRL, 2012  
6.4.2.2. Hydrocortisone  
 
Acceptable Daily Intake (ADI)  
 0.001 μg/kg  
body weight  Cattle  Milk 
(µg/l)  10 Canadian MRL(2011)  
6.4.2.3. Prednisolone  
Acceptable Daily Intake (ADI)  
0.0002 mg/kg  
body weight  Cattle  
 Muscle  4  
 
 
COMMISSION 
REGULATION (EU) 
No 37/2010  Liver  10 
Kidney  10 
Fat 4 
Milk 
(µg/l)  6 
 
 71 
 6.5.  MAXIMUM RESIDUE LIMITS  (MRLs) OF HORMONES  
 
Drug groups  Food commodity   
MRL g/kg 
  
References  
(MRL)  Species  Tissue 
or 
product  
6.5.1. Cloprostenol  
 
Acceptable Daily Intake 
(ADI)  
0.075 µg/kg  
body weight  
 Cattle  Edible 
tissues   
No need to 
establish  Annex 11of 
Council regulation  
(EEC)No 2377/90  
6.5.2. Estradiol -beta  
 
Acceptable Daily Intake 
(ADI)  
0-0.05 μg/kg  
body weight  
 
 
 Cattle  Muscle   
unnecessary   
CAC/MRL 2 -2011  
Liver  unnecessary  
Kidney  unnecessary  
Fat  
unnecessary  
6.5.3. Gonadotrophin  
 
Acceptable Daily Intake 
(ADI)  
42.25 I.U. /kg  
body weight   
All food 
producing 
species  Not 
applica
ble  
No MRL 
required   
COMMISSION 
REGULATION (EU) 
No 37/2010  
6.5.4. Melengestrol acetate  
 
Acceptable Daily Intake 
(ADI)  
0-0.03 μg/kg  
body weight  
 Cattle  
 Muscle  1  
 
 
CAC/MRL 2 -2012 
 
 
 
 Liver  10 
Kidney  2 
Fat 
 18 
 
6.5.5. Oxytocin  
 
Acceptable Daily Intake 
(ADI)  
μg/kg  
body weight  
  
All food 
producing 
species  Not 
applica
ble  
No MRL 
required  EMEA/MRL/054/95  72 
 6.5.6. Progesterone  
  
Acceptable Daily Intake 
(ADI)  
0-30 μg/kg  
body weight  Cattle  
 Muscle  unnecessary   
 
 
 
CAC/MRL 2 -2012  Liver  unnecessary  
Kidney  unnecessary  
Fat unnecessary  
Milk 
(µg/l)  unnecessary  
6.5.7. Testosterone  
 
Acceptable Daily Intake 
(ADI)  
0-2 μg/kg  
body weight   Cattle  
 
 
 
 Muscle  unnecessary   
 
CAC/MRL 2 -2011 
 
 Liver  unnecessary  
Kidney  unnecessary  
Fat unnecessary  
Milk 
(µg/l)  unnecessary  
6.6.  MAXIMUM RESIDUE LIMITS  OF GROWTH  PROMOTING               
AGENTS  
 
Drug groups  Food commodity   
MRL g/kg 
  
References  
(MRL)  Species  Tissue 
or 
product  
6.6.1. Arsanilic acid  
 
Acceptable Daily Intake (ADI)  
not established  Chicken  Muscle  500 
 
 
Canadian MRL(2011)  
 Liver  2000  
Eggs  500 
Turkey  Muscle  500 
Liver  2000  
6.6.2. Clenbuterol   
hydrochloride *                  
  
Acceptable Daily Intake (ADI)  
0-0.004 μg/kg  
body weight  
 
* banned in Food Animal 
Residue Avoidance Databank  Cattle  
 
 Muscle  0.1  
 
COMMISSION 
REGULATION (EU) 
No 37/2010  
 Liver  0.5 
Kidney  0.5 
Fat 0.2  
CAC/MRL 2 -2011 
Milk 
(µg/l)   
0.05 73 
 and US FDA  
 
6.6.3. Ractopamine  
  
Acceptable Daily Intake (ADI)  
0.001 mg/kg  
body weight  
 Cattle  
 
 
 Muscle  10  
Compendium MRL 
Codex  
 Liver  40 
Kidney  10 
Fat 10 
6.6.4. Roxarsone  
 
Acceptable Daily Intake (ADI)  
25 μg/kg  
body weight   
 
 Chicken  
 
 Muscle  500 
Canadian MRL(2011)  
 Liver  200 
Eggs  500 
Turkey  
 Muscle  500 
Liver  200 
6.6.5. Trenbolone  acetate  
  
Acceptable Daily Intake (ADI)  
0-0.02 µg/kg  
body weight   
 Cattle  
 Muscle  2 CAC/MRL 2 -2011  
Liver  10 
Kidney  10 Australian standard 
MRL, 2012  
Chicken  
 Muscle  2000  
Australian standard 
MRL, 2012  Liver  5000  
Kidney  5000  
Eggs  30 
6.6.6. Zeranol  
 
Acceptable Daily Intake (ADI)  
0-0.5 μg/kg  
body weight   Cattle  
 
 Muscle  2 CAC/MRL 2 -2011  
Liver  10 
Kidney  20 Australian standard 
MRL, 2012  Fat 20 
6.6.7. Zilpaterol  
  
Acceptable Daily Intake (ADI)  
0.083 μg/Kg  
body weight  Cattle  
 Muscle  2 
Canadian MRL(2011)  
 
 Liver  5 
Kidney  5 74 
 6.7.  MAXIMUM RESIDUE LIMITS  OF NERVOUS  SYSTEM  DRUGS  
 
Drug groups  Food commodity   
MRL g/kg 
  
References  
(MRL)  Species  Tissue or 
product  
6.7.1. Doxapram HCl  
 
Acceptable Daily Intake 
(ADI)  
not established  All 
mammalian 
food 
producing 
species   
Not 
applicable   
No MRL 
required  COMMISSION 
REGULATION 
(EU) No 37/2010  
 
6.7.2. Ketamine  
 
Acceptable Daily Intake 
(ADI)  
not established   
All food 
producing 
species  Not 
applicable   
No MRL 
required   
COMMISSION 
REGULATION 
(EU) No 37/2010  
6.7.3. Procaine HCl  
 
Acceptable Daily Intake 
(ADI)  
not established    
All food 
producing 
species  Not 
applicable   
No MRL 
required   
COMMISSION 
REGULATION 
(EU) No 37/2010  
6.7.4. Tricaine 
Methanesulfonate  
 
Acceptable Daily Intake 
(ADI)  
not established    
Salmonids   
Muscle   
10  
 
Canadian 
MRL(2011 )  
skin  
10 
 
 
 
 
 
 75 
 6.8.  MAXIMUM RESIDUE LIMITS  OF CARDIOVASCULAR  SYSTEM  
DRUGS  
 
Drug groups  Food commodity   
MRL g/kg 
  
References  
(MRL)  Species  Tissue or 
product  
6.8.1. Epinephrine  
 
Acceptable Daily Intake 
(ADI)  
not established  All food 
producing 
species   
Not 
applicable   
No MRL 
required  COMMISSION 
REGULATION 
(EU) No 37/2010  
 
 
 
6.9.  MAXIMUM RESIDUE LIMITS  OF RESPIRATORY  SYSTEM  DRUGS  
 
Drug groups  Food commodity   
MRL g/kg 
  
References  
(MRL)  Species  Tissue or 
product  
6.9.1. Bromhexine  
 
Acceptable Daily Intake 
(ADI)  
0.3 mg per person  Cattle   
Not 
applicable   
No MRL 
required  COMMISSION 
REGULATION 
(EU) No 37/2010  
 
Poultry   
Not 
applicable   
No MRL 
required  
6.9.2. Etamiphylline 
camsilat  
Acceptable Daily Intake 
(ADI)  
not established   All food 
producing 
species   
Not 
applicable   
No MRL 
required  COMMISSION 
REGULATION 
(EU) No 37/2010  
 
 
 
 
 
 
 76 
 6.10.  MAXIMUM RESIDUE LIMITS  OF DIGESTIVE  SYSTEM  DRUGS  
 
Drug groups  Food commodity   
MRL g/kg 
  
References  
(MRL)  Species  Tissue or 
product  
6.10.1 . Atropine sulfate  
 
Acceptable Daily Intake 
(ADI)  
0-0.0002 mg/kg  
body weight  
 All food 
producing 
species   
Not 
applicable   
No MRL 
required  COMMISSION 
REGULATION 
(EU) No 37/2010  
 
6.10.2 . Poloxalene  
Acceptable Daily Intake 
(ADI)  
0.02 mg/kg  
body weight  
  
All food 
producing 
species   
Not 
applicable   
No MRL 
required   
COMMISSION 
REGULATION 
(EU) No 37/2010  
 
 
 
6.11.  MAXIMUM RESIDUE LIMITS  OF URINARY  SYSTEM  DRUGS  
 
Drug groups  Food commodity   
MRL g/kg 
  
References  
(MRL)  Species  Tissue or 
product  
6.11.1 . Hydrochlorothiazide  
 
Acceptable Daily Intake (ADI)  
12.5 mg /kg  
body weight  
 Cattle   
Not 
applicable   
No MRL 
required  COMMISSION 
REGULATION (EU) 
No 37/2010  
 
 
 
 
 
 77 
 7. REFERENCES  
ACCEPTABLE DAILY INTAKES (ADI) FOR AGRICULTURAL AND 
VETERINARY CHEMICALS. Australian Government, Department of Health and 
Aging Office of Chemical Safety. 31 December 2012.  
Australian Standard (2012), Australian Pesticides and Veterinary Medicines 
Authority,  The MRL Standard,  Maximum residue limits in food and animal 
feedstuff  July 2012.  
Canadian Standards, Maximum residue limits (MRLs) of veterinary drugs in food, 
2011.  
Codex  Alimentarius Commission (CAC), Maximum residue limits (MRLs) of 
veterinary drugs in food . 35th Session of the Codex Alimentarius Commission (July 
2012)   
Codex  Alimentarius Commission (CAC), Maximum residue limits (MRLs) of 
veterinary drugs in food 2011.  
COMMISSION REGULATION (EU) No 37/2010  
COUNCIL REGULATION (EEC) No 2377/90  
http://www.fve.org/veterinary/pdf/medicines/regulation_2377_90_en.pdf  
EMEA/MRL /865/03 -FINAL, June 2004 : The European Agency for the Evaluation 
of Medicinal products.  Veterinary Medicines and Information Technology Unit.  
EMEA/MRL/CVMP/151/99 -FINAL, March 1999. The European Agency for the 
Evaluation of Medicinal products.  Veterina ry Medicines and Information 
Technology Unit. Committee for Veterinary Medical Products.  
EMEA/MRL/889/03 -FINAL. June 2004. The European Agency for the Evaluation 
of Medicinal products.  Veterinary Medicines and Information Technology Unit. 
Committee for Ve terinary Medical Products.  
EMEA/MRL/342/00 -FINAL. January 2001. The European Agency for the 
Evaluation of Medicinal products.  Veterinary Medicines and Information 
Technology Unit. Committee for Veterinary Medical Products.  78 
 EMEA/MRL/565/99 -FINAL April (199 9). The European Agency for the Evaluation 
of Medicinal products.  Veterinary Medicines and Information Technology Unit. 
Committee for Veterinary Medical Products.  
EMEA/MRL/342/98 -FINAL. February 1998. The European Agency for the 
Evaluation of Medicinal pr oducts.  Veterinary Medicines and Information 
Technology Unit. Committee for Veterinary Medical Products.  
EUROPEAN COMMUNITY COMMENTS ON CODEX CIRCULAR LETTER CL 
2005 -10 RVDF.  
EMEA/MRL/079/96 -FINAL, March 1996. The European Agency for the Evaluation 
of Med icinal products.  Veterinary Medicines and Information Technology Unit.  
JECFA (2011) JOINT FAO/WHO EXPERT COMMITTEE ON FOOD 
ADDITIVES Seventy -fifth meeting (Residues of veterinary drugs) Rome, 8 –17 
November 2011  
JECFA (2012) JOINT FAO/WHO EXPERT COMMITTEE ON FOOD 
ADDITIVES. Summary report of the seventy -fifth meeting of JECFA (January, 
2012)  
The Japan Food Chemical Research Foundation, 2012  
US Maximum Residue Levels in Food Commodities.  
USDA Foreign Agricultural Service. Gain Report Number: JA7053,2007.  
 
 
 
 
 
 
 
 
 
 79 
  
 
 
 
 
 
 
 
 
 
 
 
AN APPENDIX  OF 
 
MAXIMUM  RESIDUES  LIMITS (MRLs) OF VETERINARY 
DRUGS IN FOODS  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 80 
 1. LIST OF VETERINARY DRUGS  
 
No. Drug  Page  No. Drug  Page  
1 Abamectin  49 78 Mebendazol  58 
2 Albendazole  49 79 Melengestrol acetate  80 
3 Amitraz  69 80 Meloxicam  76 
4 Amoxicillin  13 81 Methyl benzoquate  44 
5 Ampicillin  13 82 Monensin  45 
6 Amprolium  40 83 Monepantel  59 
7 Apramycin  8 84 Moxidectin  60 
8 Arsanilic acid  82 85 Narasin  46 
9 Atropine sulfate  90 86 Natamycin  39 
10 Avermectin  51 87 Neomycin  10 
11 Avilamycin  27 88 Nicarbazin  46 
12 Bacitracin  28 89 Nitobimin  60 
13 Benzyl penicillin  14 90 Nitroxynil  61 
14 Bromhexine  89 91 Novobiocin  7 
15 Carprofen  75 92 Nystatin  39 
16 Cefalonium  11 93 Oleandomycin  23 
17 Cefapirin  11 94 Ormetoprim  46 
18 Ceftiofur  12 95 Oxfendazole  61 
19 Cefuroxime  12 96 Oxyclozanide  62 
20 Chlortetracycline  35 97 Oxytetracycline  36 
21 Clazuril  41 98 Oxytocin  80 
22 Clenbuterol  82 99 Permethrin  74 
23 Clopidol  41 100 Phoxim  74 
24 Cloprostenol  79 101 Piperazine  62 
25 Closantel  52 102 Pirlymicin  22 
26 Cloxacillin  14 103 Poloxalene  90 
27 Colistin  28 104 Polymixin B  29 
28 Cyhalothrin  70 105 Praziquantel  63 
29 Cyfluthrin  69 106 Prednisolone  78 
30 Cypermethrin  70 107 Procaine benzyl penicillin  15 
31 Cyromazine  71 108 Procaine HCl  86 81 
 32 Danofloxacin  18 109 Progesterone  80 
33 Decoquinate  41 110 Ractopamine  83 
34 Deltamethrin  71 111 Rafoxanide  64 
35 Derquantel  52 112 Robenidine hydrochloride  46 
36 Dexamethasone  78 113 Roxarsone  83 
37 Diazinon  72 114 Salinomycin Sodium  47 
38 Diclazuril  42 115 Sarafloxacin  21 
39 Diclofenac  75 116 Semduramycin  47 
40 Dicyclanil  72 117 Spectinomycin  7 
41 Difloxacin  19 118 Spiramycin  23 
42 Dihydrostreptomycin  8 119 Streptomycin  11 
43 Diminazene  67 120 Sulfabenzamide  30 
44 Dinitolmide (Zoalene)  42 121 Sulfacetamide  30 
45 Doramectin  53 122 Sulfachlorpyridazine  30 
46 Doxapram  HCl 85 123 Sulfadiazine  30 
47 Doxycycline  36 124 Sulfadimethoxine  31 
48 Emamectin  73 125 Sulfadimidine (Sulfamethazine)  31 
49 Enrofloxacin  19 126 Sulfadoxine  32 
50 Epinephrine  88 127 Sulfaethoxypyridazine  32 
51 Eprinomectin  53 128 Sulfaguanidine  33 
52 Erythromycin  22 129 Sulfamerazine  33 
53 Estradiol -beta  79 130 Sulfanilamide  33 
54 Etamiphylline  camsilate  89 131 Sulfanitran  33 
55 Ethopabate  42 132 Sulfapyridine  34 
56 Febantel  54 133 Sulfaquinoxaline  34 
57 Fenbendazole   134 Sulfathiazole  35 
58 Florfenicol  16 135 Teflubenzuron  74 
59 Fluazuron  73 136 Testosterone  81 
60 Flubendazole  55 137 Tetracycline  37 
61 Flumequine  20 138 Thiabendazole  64 
62 Flunixin  meglumine  75 139 Thiamphenicol  16 
63 Gentamicin  9 140 Tiamulin  27 
64 Gonadotrophin  80 141 Tilmicosin  24 
65 Halofuginone  hydrobromide  43 142 Tolfenamic  acid  77 82 
 66 Hydrochlorothiazide  91 143 Toltrazuril   
67 Hydrocortisone  78 144 Trenbolone  acetate  83 
68 Imidocarb  68 145 Tricaine  methane  sulfonate  87 
69 Isometamidium  68 146 Trichlorfon (metrifonate)  74 
70 Ivermectin  56 147 Triclabendazole  65 
71 Ketamine  85 148 Trimethoprim  18 
72 Ketoprofen  76 149 Tulathromycin  24 
73 Lasalocid Sodium  43 150 Tylosin  25 
74 Levamisole  57 151 Virginiamycin  29 
75 Lincomycin  22 152 Xylazine  87 
76 Maduramicin Ammonium  44 153 Zeranol  84 
77 Marbofloxacin  21 154 Zilpaterol  84 
 
 
 
 
 
 
 
 
 
 
 
 
 
 83 
  
2. RESIDUE DEFINITION, METHODS OF DTECTION AND WITHDRAWAL PEROIDS OF VETERINARY DRUGS  
2.1. RESIDUE DEFINITION, METHODS OF DTECTION AND WITHDRAWAL PEROIDS OF ANTIBACTERIAL DRUGS  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of detection  
(Technique)   
 
References  
  
 
Withdrawal 
period   
 
References  
 Species  Tissue or 
product  
2.1.1.AMINOCOUMARIN    
ANTIBIOTIS  
 
2.1.1.1. Novobiocin  
 
  
 
 
Cattle   
 
 
Muscle   
 
Novobiocin  
Gas Chromatography  
(GC)   
 
 
J. Assoc . Off. Anal . 
Chem.  1988 Jul -
Aug;71(4):776 -  
 
4 days veal 
calves  
 
30 days 
Intramammary   
 
Food Animal Residue 
Avoidance & Depletion 
Program (FARAD) 
http://www.farad.org/eldu
/prohibit.html  
Pfizer,  Inc. 
 Milk  3 days 
Intramammary  
2.1.2. AMINOCYCLITOL  
ANTIBIOTICS  
 
2.1.2.1. Spectinomycin  
 
 
  
 
 
Cattle  
 
 
  
 
 
Muscle   
 
 
Spectinomycin 
 
 
 
Liquid 
Chromatography  (LC)  
 
 
FAO Food & Nutrition 
Paper 41/11; see also 
Report of 12th Meeting, 
CCRVDF: method  
issued by German 
Federal Institute for 
Consumer Health  
 
 
32 days  
  
 
 
The Veterinary 
Formulary 6th ed. 
Yolande Bishop 2005 
pp.167  
 
   
10 days lambs,  
The Veterinary 84 
 Goat  Muscle   Protection and 
Veterinary Medicine, 
applicable to 
spectinomycin residues 
in muscle, kidney, liver 
and fat of calves, pigs 
and chic kens, and in 
egg. oral Formulary 6th ed. 
Yolande Bishop 2005 
pp.167  
 
 
Chicken   
Muscle   
5 days  
 
21 days inject.  AAMER et al. / Int. J. 
Agri. Biol., Vol. 2, No. 3, 
2000  
 
Adwia Pharmact.Co. 
Egypt  
2.1.3.AMINOGLYCOSIDES 
ANTIBIOTICS  
 
2.1.3.1. Apramycin  
 
  
 
Cattle   
Muscle   
 
Apramycin  
 
High Performance 
Liquid 
Chromatography 
(HPLC )  A 
  
  
 
COMPENDIUM OF 
METHODS OF 
ANALYSIS   
28 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.154  
 
Goat   
Muscle   
35 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.153  
 
Chicken   
Muscle   
7 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 2005 
pp.153  
2.1.3.2.Dihydrostreptomycin  
 
 
 
  
 
Cattle  
  
 
Muscle   
Dihydrostreptomycin  
Gas Chromatography 
– Mass 
Spectrophotometry  
 FAO Food & Nutrition 
Paper 41/1  
 
4; see also Gerhardt, 
G.C., Salisbury, C.D.C., 
& MacNeil, J.D. (1994) 
J. AOAC Int . 77: 334 -
337; data provided to  
 
30 days  
Intramammary  
60 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 135  
 
Food Animal Residue 
Avoidance & Depletion 
Program (FARAD) 
http://www.farad.org/eldu85 
  
 (GC-MS) CCRVDF by Canada, 
2nd laboratory 
verification  of 
performance reported 
by UK  /prohibit.html  
Milk  4 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 135  
2.1.3.3.Gentamicin  
 
 
 
 
 
 
 
 
 
 
 
 
 
 Cattle  Muscle   
 
 
 
Sum of 
gentamicinC1, 
gentamicin 
C1a,gentamicin C2 
and gentamicin C2a  
 
 
 
Liquid 
Chromatography  (LC) 
 
  
 
 
 
FAO Food &  
Nutrition Paper  
41/11  
 
 
 
 
 
 
 
 360 days  
 
 
 
18 months  
 Drugs and Their Usage  
William D.Grimly 1998  
pp. 135  
 
Food Animal Residue 
Avoidance & Depletion 
Program (FARAD) 
http://www.farad.org/eldu
/prohibit.html  
Milk  5 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 135  
 
Chicken   
Muscle   
63 days   
Drugs and Their Usage  
William D.Grimly 1998  
pp. 135  
Goats  Muscle  18 months  Food Animal Residue 
Avoidance &  Depletion 
Program (FARAD) 
http://www.farad.org/eldu
/prohibit.html  
Milk  10 days  Food Animal Residue 
Avoidance & Depletion 
Program (FARAD) 86 
 http://www.farad.org/eldu
/prohibit.html  
2.1.3.4.Neomycin  Cattle  Muscle   
 
 
 
 
Neomycin B  
 
 
Liquid 
Chromatography (LC)   
 
 
 
 
 
52nd JECFA; data 
provided to CCRVDF  
 30 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 137  
Milk  2 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 137  
 
Sheep   
Muscle  20 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 137  
 
Goat   
Muscle  28 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.154  
Chicken  Muscle   Zero  The Veterinary 
Formulary  6th ed. 
Yolande Bishop , 2005 
pp.154  
2.1.3.5.Streptomycin  
 
 Cattle  Muscle  Streptomycin  
Liquid 
Chromatography (LC)  FAO Food & Nutrition 
Paper 41/14; see also 
Gerhardt, G.C., 
Salisbury, C.D.C., & 
MacNeil, J.D. (1994) J. 
AOAC Int . 77: 334 -337; 
data provided  to 
CCRVDF by Canada, 
2nd laboratory 
verification  of 
performance reported 14 days  
2 days ( oral)   
 
The Veterinary 
Formulary 6th ed. 
Yolande Bishop , 2005 
pp.155  
 Milk  2 days  
Sheep  Muscle  14 days  
Goat  Muscle  14 days  87 
 by UK  
2.1.4.BETA  LACTAM  
2.1.4.1.Cephalosporins  
2.1.4.1.1. Cefalonium  
  
Cattle  Muscle  Cefalonium  
High Performance 
Liquid 
Chromatography 
(HPLC)    
 
 
 
 
 
Annex 1 EEC NO 
2377/90  
 
 
 
 
 
 21 days   
 
Shering -Plough  Milk   
54 days  
2.1.4.1.2. Cefapirin  
 
 
 
 
 Cattle  
 
  
 Muscle   
 
 
Sum of cefapirin and 
desacetylcefapirin  
High Performance 
Liquid 
Chromatography 
(HPLC)   Sodium 4 days  
Benthazine 42 
days 
 
 
Intramammary 
4 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 130  
Milk  Sodium 4 days  
Benthazine 3.5 
days Drugs and Their Usage  
William D.Grimly 1998  
pp. 137  
2.1.4.1.3.Ceftiofur  
 Cattle Muscle   
 
 
 
 
Sum of all 
residuesretaining the 
betalactam 
structureexpressed as 
desfuroylceftiofur   
 
 
 
 
Report of 12th Meeting, 
CCRVDF; FAO Food 
& Nutrition Paper 41/8  
 Canada   Zero  
 
8 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 128  
The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.150  
Milk  Canada   Zero  Drugs and Their Usage  
William D.Grimly 1998  88 
  
Liquid 
Chromatography (LC)  pp. 128  
 
The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.150  
2.1.4.1.4.Cefuroxime  
 Cattle  Muscle   
Not established   7 days   
Schering -Plough  
Milk  3 days  
2.1.4.2.Penicillins  
2.1.4.2.1.Amoxicillin  
 
 
 
 
  
 
Cattle  Muscle  Amoxicillin  
High Performance 
Liquid 
Chromatography 
(HPLC)  Ethical  
Committee for Animal 
Testing (No. of the 
proposal  66/2003).  
Acta Poloniae 
Pharmaceutica n Drug 
Research, Vol. 67 No. 6 
pp. 729 -732, 2010  Inject. 25 days  
Oral calves 20 
days 
 
18 days  
Intramammary 
12 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 125  
 
The Veterinary 
Formulary Sixth edition 
Edited by Yolande 
Bishop 6th ed 2005 pp.145  
Milk    4 days inject.  
2.5 days 
intramammary  Drugs and Their Usage  
William D.Grimly 1998  
pp. 1 25 
Chicken  Muscle  Oral 2 days  The Veterinary 
Formulary  
Sixth edition  
Edited by Yolande 
Bishop 6th ed 2005 
pp.14 6 
2.1.4.2.2. Ampicillin  
Cattle  Muscle    6 days  Drugs and Their Usage  
William D.Grimly 1998  89 
   Ampicillin  
High Performance 
Liquid 
Chromatography 
(HPLC)  
 
 
  
Am J Vet Res.  2005 
Jan;66(1):108 -12. 
 
Multivariate meta -
analysis of 
pharmacokinetic studies 
of ampicillin trihydrate 
in cattle  
  
 
 
18 days  
 
 
 pp. 126  
Boehringer Ingelheim 
Vetmedica, Inc.  
The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.148  
Milk  2 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 1 26 
 
Boehringer Ingelheim 
Vetmedica, Inc.  
2.1.4.2.3. Benzyl penicillin  
 
 
 
 
 
 Cattle  Muscle   
 
 
 
 
benzylpenicillin  
 
High Performance 
Liquid 
Chromatography 
(HPLC)  Fresenius J Anal Chem.  
2001 Sep;371(1):64 -7. 
Determination of 
benzylpenicillin, 
oxacillin, cloxacillin, 
and dicloxacillin in 
cows' milk by ion -pair 
high-performance 
liquid chromatography 
after precolumn 
derivatization.  
Marchetti M , 21 days   i.m.  
42 days s.c.  
 
18 days  
 
 
 
 Drugs and Their Usage  
William D.Grimly 1998  
pp. 131  
 
The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.145  
Milk  3 days Drugs and Their Usage  
William D.Grimly 1998  90 
  
 Schwaiger I , Schmid 
ER. pp. 1 31 
2.1.4.2.4. Cloxacillin  
 
 Cattle  Muscle   
Cloxacillin  
High Performance 
Liquid 
Chromatography 
(HPLC)    
Fresenius J Anal Chem.  
2001 Sep;371(1):64 -7. 
Determination of 
benzylpenicillin, 
oxacillin, cloxacillin, 
and dicloxacillin in 
cows' milk by ion -pair 
high-performance 
liquid chromatography 
after precolumn 
derivatization.  
Marchetti M , 
Schwaiger I , Schmid 
ER. Benzathine 30 
days 
 
 
10 days Drugs and Their Usage  
William D.Grimly 1998  
pp. 130  
 
 
Schering -Plough Animal 
Health  
Milk  30 days  
benzathine  
 
 
2 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 1 30 
 
Schering -Plough Animal 
Health  
2.1.4.2.5. Procaine benzyl 
penicillin  
 
 Cattle  Muscle   
 
benzyl penicillin  
High  Performance 
Liquid 
Chromatography 
(HPLC)   
Boison,J.O (1992) 
Chromatographic 
method of analysis of 
penicillin in food -
animal 
tissues.J.Chromatogr.62
4:171 -192 21 days   i.m.  
42 days s.c.  
 
60 days 
benzathine  
 Drugs and Their Usage  
William D.Grimly 1998  
pp. 1 32 
 
The Veterinary 
Formulary Sixth edition  
Edited by Yolande 
Bishop 6th ed 2005 pp.145  
Milk  3 days G.C. Hanford Mfg. Co.  
Sheep  Muscle  9 days 
 91 
 60 days 
benzathine  The Veterinary 
Formulary  Sixth edition  
Edited by Yolande 
Bishop 6th ed 2005 pp.145  
2.1.5. 
CHLORAMPHENICOLS  
2.1.5.1.Thiamphenicol  
  
 
 
Cattle  
  
 
Muscle   
 
Thiamphenicol  
High Performance 
Liquid 
Chromatography 
(HPLC)   
 
T. Nagata a & M. 
Saeki a(1992)  
Journal of Liquid 
Chromatography  
Volume 15 , Issue 12 , 
1992  
 
Simultaneous 
Determination  of 
Thiamphenicol , 
Florfenicol, and 
Chloramphenicol 
Residues in Muscles of 
Animals and Cultured 
Fish by Liquid 
Chromatography   
 
28 days 
  
Dutch Farm International 
B.V.  
Industrieweg 14c – 1231 
KH Loosdrecht - Holland  
P.O. Box 63 – 1230 AB 
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
Milk  3 days Dutch Farm International 
B.V.  
Industrieweg 14c – 1231 
KH Loosdrecht - Holland  
P.O. Box 63 – 1230 AB 
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
2.1.5.2.Florfenicol  Cattle  Muscle   
  
 28 days 
 Food Animal Residue 
Avoidance & Depletion 92 
   
 
Sum of florfenicol  
and its 
metabolitesmeasured 
asflorfenicol -amine  
 
Liquid 
Chromatography (LC)  CLG -FLOR1.04  
Determination and 
Confirmation of 
Florfenicol  
United States 
Department of 
Agriculture Food Safety 
and Inspection Service, 
Office of Public Health 
Science   
 
 
 
44 days Program (FARAD) 
http://www.farad.org/eldu
/prohibit.html  
 
The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.158  
 Milk  120 hours  
 
 
 
 Food Animal Residue 
Avoidance & Depletion 
Program (FARAD) 
http://www.farad.org/eldu
/prohibit.html  
Fish Muscle  15 days Intervet/Schering -Plough  
Animal Health Corp.  
2.1.6. 
DIAMINOPYRIMIDINES  
2.1.6.1. Trimethoprim  
 
 
 
 
  
Cattle  
Muscle  Trimethoprim  
 
Spectrophotometric   
 
Hacettepe University 
Journal of the Faculty 
of Pharmacy  
Volume 29 / Number 2 
/ July 2009 / pp. 95 -104 
Spectrophotometric 
Determination and  
Stability Studies of 
Sulfamethoxazole and 
Trimethoprim in Oral 
Suspension by  
Classical Least Square 
Calibration Method   
10 days  
 
Medical Professions for 
Vet.Products&Fodders 
Additions Co.Egypt  93 
  
  
Chicken  Muscle  10 days 
 AAMER et al. / Int. J. 
Agri. Biol., Vol. 2, No. 3, 
2000  
2.1.7. 
FLUOROQUINOLONES  
2.1.7.1. Danofloxacin  
  
Cattle   
 
Muscle   
 
 
 
Danofloxacin  
 
Liquid 
Chromatography (LC)   
 
 
FAO Food & Nutrition 
Paper 41/10; see also 
Report of 12th & 13th 
Meetings, CCRVDF. 
Contact for method 
provided to CCRVDF: 
AFSSA -LERMVD, 
Javene,  BP090203 -
35302, Fougeres, 
France   
8 days  Saunders Handbook of 
Veterinary Drugs, Mark 
G. Papich,  2004  
 
The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.163  
Milk  4 days Saunders Handbook of 
Veterinary Drugs, Mark 
G. Papich, 2004  
 
The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.163  
2.1.7.2. Difloxacin  
 Cattle  Muscle  Difloxacin  
High Performance 
Liquid 
Chromatography 
(HPLC)  Pharm Res.  1990 
Nov;7(11):1177 -80. 
Determination of 
temafloxacin, 
sarafloxacin, and 
difloxacin in bulk drug 
and dosage forms by 
high-performance Not 
established   
- 
Poultry  Muscle   
 
 
1 day  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.163  
 
Pfizer Limited  
Ramsgate Road  94 
 liquid chromatography.  
Bauer JF , Elrod L Jr , 
Fornnarino JR , 
Heathcote DE , Krogh 
SK, Linton CL , Norris 
BJ, Quick JE  
 Sandwich  
Kent CT13 9NJ  
United Kingdom  
2.1.7.3. Enrofloxacin  
 
 
  
 
 Cattle  
 
 
 
 
 
 
 
 Muscle   
 
Sum of 
enrofloxacinand 
ciprofloxacin  
High Performance 
Liquid 
Chromatography 
(HPLC)  Marinês J. e Souza  
Celso F. Bittencourt  
Lisoni M. Morsch  
) 2002)  
Journal  of 
Pharmaceutical  and 
Biomedical  Analysis  
Volume 28, 6 , (15), 
1195 –1199  
LC determination  
of enrofloxacin  
 28 days 
 
 
14 days  Saunders Handbook of 
Veterinary Drugs, Mark 
G. Papich, 2004  
 
The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.164  
Milk  84 h The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.164  
Poultry  
Muscle  8 days  
 
 
 
 
4 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop  6th ed 
2005 pp.164  
 
Dutch Farm International 
B.V.  
Industrieweg 14c – 1231 
KH Loosdrecht - Holland  
P.O. Box 63 – 1230 AB 95 
 Loosdrecht - Holland  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
2.1.7.4. Flumequine  
 Cattle  Muscle   
 
Flumequine  
Liquid 
Chromatography (LC)   
 
FAO Food & Nutrition 
Paper 41/10  
   
Chicken  
 Muscle  2 days Dutch Farm International 
B.V.  
Industrieweg 14c – 1231 
KH Loosdrecht - Holland  
P.O. Box 63 – 1230 AB 
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com   Eggs  2 days  
2.1.7.6. Marbofloxacin  
 Cattle  Muscle  Marbofloxacin  
High Performance 
Liquid 
Chromatography 
(HPLC)  Mahmood AH , Medley 
GA, Grice JE , Liu X , 
Roberts MS .(2012)  
J Pharm Biomed Anal.  
2012 25; 62:220 -3. 
Determination of 
trovafloxacin and 
marbofloxacin in sheep 
plasma samples by 
HPLC using UV 6 days The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.165  
Milk  1.5 days The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.165  96 
 detection.  
2.1.7.7. Sarafloxacin  
 Chicken  
 
 
 
 
 Muscle  Sarafloxacin  
High Performance 
Liquid 
Chromatography 
(HPLC)  FAO Food & Nutrition 
Paper 41/11  
 3 days  Residues of Some 
Veterinary Drugs in 
Animals and Foods 
vol.11,   Joint FAO/WHO 
Expert Committee on 
Food Additives ,pp.115  
2.1.8. LINCOSAMIDES  
2.1.8.1. Lincomycin  
 
 Cattle  
 
 
 Muscle  Lincomycin 
 
Gas Chromatography 
– Mass 
Spectrophotometry  
(GC-MS) FAO Food & Nutrition 
paper 41/13  
 
 6 days Modern Livestock& 
Poultry Production 7th ed. 
James R.Gillespie 2004, 
pp.152  
Chicken  
 Muscle  7 days  Medical Professions for 
Vet.Products&Fodders 
Additions Co.Egypt  
2.1.8.2. Pirlymicin  
 Cattle  
 Muscle  Pirlymicin  
High Performance 
Liquid 
Chromatography 
(HPLC)  Antibiotics in milk  
Nestlé Research  Center  
Quality & Safety 
Department  
1000 Lausanne 26 
(Switzerland)  23 days Pfizer Ltd  
Ramsgate Road  
Sandwich  
Kent CT13 9NJ  
UK 
Milk  5 days Pfizer Ltd  
Ramsgate Road  
Sandwich  
Kent CT13 9NJ  
UK 
2.1.9. MACROLIDES  
2.1.9.1. Erythromycin  
  
Cattle  
 
 
 Muscle   
 
 
Erythromycin A   
Griessmann K , 
Kaunzinger A , 
Schubert -Zsilavecz M , 3 days Medical Professions for 
Vet.Products&Fodders 
Additions Co.Egypt  97 
  
   
High Performance 
Liquid 
Chromatography 
(HPLC)  
 
 
 
 Abdel -Tawab M (2007)  
Pharmazie.  62(9):6 68-
71. 
A rapid HPLC -UV 
method for the 
quantification of 
erythromycin in 
dermatological 
preparations  Sheep  Muscle  3 days Medical Professions for 
Vet.Products&Fodders 
Additions Co.Egypt  
Chicken  
 Muscle  3 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.156  
Eggs  6 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.156  
2.1.9.2. Oleandomycin  
 
 
 
 Cattle  Muscle  Oleandomycin  
High Performance 
Liquid 
Chromatography 
(HPLC)  
 Journal of 
Chromatography, 353 
(1986) 33 -38 
HIGH -
PERFORMANCE 
LIQUID 
CHROMATOGRAPHI
C ANALYSIS OF  
OLEANDOMYCIN IN 
SERUM AND URINE  
C. STUBBS, J. M. 
HAIGH and I. 
KANFER    
Chicken  Muscle  5 days  Modern Livestock & 
Poultry Production 7th ed. 
James R.Gillespie 2004  
2.1.9.3. Spiramycin  
 Cattle  
 
 
 Muscle  Sum of 
spiramycinand 
neospiramycin  data provided to 
CCRVDF; 43rd & 47th 
JECFA  
 52 days Ceva Animal Health 
Limited  
Unit 3  
Anglo Office Park  98 
  
 
 
 
  
Liquid 
Chromatography (LC)  
 White Lion Road  
Amersham  
Buckinghamshire  
HP7 9FB  
Milk  10 days Ceva Animal Health 
Limited  
Unit 3 Anglo Office Park  
White Lion Road, 
Amersham  
Buckinghamshire HP7 
9FB 
2.1.9.4. Tilmicosin  
 
  
Cattle  
 
  
 
Muscle   
 
 
Tilmicosin 
 
High Performance 
Liquid 
Chromatography 
(HPLC)   
 
 
 
FAO Food & Nutrition 
Paper 41/9  
  
 
 
60 days  
 
 
The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.157  
Sheep  Muscle  42 days  
Milk  15 days  
2.1.9.5. Tulathromycin  
 Cattle  
 Muscle  (2R,3S,4R,5R,8R,10R
,11R,12S,13S,14R) -2-
ethyl -3,4,10,13 -tetra-
hydroxy -
3,5,8,10,12,14 -
hexamethyl -11-
[[3,4,6 -trideoxy -3-
(dimethy -lamino) -β-
D-xylo-J AOAC  Int 
2011 .;94(2):436 -45. 49 days The Veterinary 
Formulary 6th ed.Yolande 
Bishop 6th ed 2005 pp.157  99 
 hexopyranosyl]oxy] -
1-oxa-6-
azacyclopent -decan -
15-one expressed 
astulathromycinequiv
alents  
HPLC/MS/MS  
2.1.9.6. Tylosin  
 Cattle  
 Muscle   
 
 
 
 
 
 
 
Tylosin A  
 
High Performance 
Liquid 
Chromatography  
 
(HPLC ) 
 
 
 
  
 
 
 
 
 
Journal of the Hellenic 
Veterinary Medical 
Society  
ISSN 1792 -2720  
Volume 49,  Number 4, 
October -December 
1998  
Determination of 
tylosin residues in 
animal tissues by 
HPLC -PDA  
 
 21 days  
 
 
 
 
28 days 
 
 
 
Oral calves  
 5 days  
 Drugs and Their Usage  
William D.Grimly 1998  
pp. 152  
 
 
The Veterinary 
Formulary 6th ed.Yolande 
Bishop 6th ed 2005 pp.157  
 
Dutch Farm International 
B.V.Industrieweg 14c – 
1231 KH Loosdrecht - 
Holland  
P.O. Box 63 – 1230 AB 
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
Milk  Milk not used  
 Drugs and Their Usage  
William D.Grimly 1998  100 
  
 
 
 
 
 
 
  
 
 
 
 
 
  
 
4.5 days 
 
 pp. 152  
 
The Veterinary 
Formulary 6th ed.Yolande 
Bishop 6th ed 2005 pp.157  
Chicken  
 
 Muscle  Oral zero  
 
 
2 days  The Veterinary 
Formulary 6th ed.Yolande 
Bishop 6th ed 2005 pp.158  
 
Dutch Farm International 
B.V.Industrieweg 14c – 
1231 KH Loosdrecht - 
Holland  
P.O. Box 63 – 1230 AB  
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
Turkey  Muscle  Oral zero  The Veterinary 
Formulary 6th ed.Yolande 
Bishop 6th ed 2005 pp.158  
2.1.10. ORTHOSOMYCIN  
2.1.10.1. Avilamycin   
Chicken   
Muscle   
 
  
J . Assoc Off Anal 
Chem.  1986 69(5):763 - 
 
  
 
 
 
 Liver  101 
  
 
Turkey  Muscle  
Dichloroisoeverninic 
acid 
GC 6. 
Gas chromatographic 
determination of 
avilamycin total 
residues in pig tissues, 
fat, blood, feces, and 
urine.  
Formica G , Giannone 
C.  
 
 
Zero   
 
The Veterinary 
Formulary 6th ed.Yolande 
Bishop 2005 pp.446  
2.1.11. Pleuromutilin  
2.1.11.1. Tiamulin  
 Chicken  Muscle   
 
 
 
Sum of metabolites 
that may be 
hydrolysed to8 -α-
hydroxymutilin  
Thin layer chromatr.  
TL  
 
J AOAC Int.  
2000;83(6):1502 -6 
Identification and 
determination of 
oxytetracycline, 
tiamulin, lincomycin, 
and spectinomycin in 
veterinary preparations 
by thin -layer 
chromatography/densito
metry.  2 days  oral  Novartis Animal Health 
UK Limited  
Frimley Business Park  
Frimley, Camberley  
Surrey, GU16 7SR  
United Kingdom  
 Eggs  Zero  
Turkey  Muscle  5 days Novartis Animal Health 
UK Limited  
Frimley Business Park  
Frimley, Camberley  
Surrey, GU16 7SR  
United Kingdom  
2.1.12. POLYPEPTIDES  
2.1.12.1. Bacitracin  
 Camel  Milk  Sum of bacitracin 
A,bacitracin B, 
andbacitracin C  
LC-MS Trends in Analytical 
Chemistry, Vol. 22, No. 
11, 2003  
Analytical 
methodologies for  Zero  
Alpharma Inc.  
 
 
Chicken   
Muscle   102 
  identifying a 
polypeptide antibiotic  
2.1.12.2. Colistin  
 
 
 
 
 
 
 
 Cattle  Muscle  
Colistin  
 
High Performance 
Liquid 
Chromatography 
(HPLC ) 
   
Ther Drug Monit.  
2000;22(5):589 -93. 
High -performance 
liquid chromatographic 
method for the 
determination of 
colistin in serum.  
Le Brun PP , de Graaf 
AI, Vinks AA .  
14 days 
 
 
Oral 1 day   
Dutch Farm International 
B.V.Industrieweg 14c – 
1231 KH Loosdrecht - 
Holland  
P.O. Box 63 – 1230 AB 
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  Sheep  Muscle  1 day  
Goat  Muscle  1 day  
Chicken  Muscle  1 day  
Turkey  Muscle  1 day  
2.1.12.3.Polymixin B  Cattle  Milk  Polymixin B  
electrophoresis with 
indirect UV detection  J Pharm Biomed Anal.  
2007 19;43(3):1013 -8. 
Simultaneous 
determination of 
neomycin sulfate and 
polymyxin B sulfate by 
capillary 
electrophoresis with 
indirect UV detection.  
Srisom P , 
Liawruangrath B , 5 days  JAVMA,vol.226(12) June 
15, 2005  103 
 Liaw ruangrath S , Slater 
JM, Wangkarn S . 
2.1.13. STREPTOGRAMINS  
2.1.13.1. Virginiamycin  Cattle  Muscle   
 
Virginiamycin M1  
  
LC-MS  
 
Analytica Chimica Acta 
483 (2003) 99 –109  
7 days  
JAVMA,vol.226(12) June 
15, 2005  
Chicken  Muscle  Zero  Canadian Food Inspection 
Agency.59 Camelot 
Drive,Ottawa,Ontario,CA
NADA, KIA 0Y9  
2.1.14. SULFONAMIDES  
2.1.14.1. Sulfabenzamide   
Cattle  Muscle  Sulfabenzamide  
CE-MS/MS  Electrophoresis.  2009 
May;30(10):1698 -707 Not 
established   
- 
2.1.14.2.Sulfacetamide  
 Cattle  
 
 
 Muscle  Sulfacetamide/ 
sulfanilamide  
Spectrophotometry  Journal of 
Pharmaceutical 
sciences 58(10)1171 -
1300   
Not 
established  
  
 
- 
 
2.1.14.3. Sulfachlorpyridazine  
  
Cattle  
 Muscle  Sulfachlorpyridazine  
High Performance 
Liquid 
Chromatography 
(HPLC ) Biomed. Eng. Appl. 
Basis Commun. 21, 457 
(2009). DOI: 
10.4015/S10162372090
01647  5 days Drugs and Their Usage  
William D.Grimly 1998  
pp. 141  
2.1.14.4. Sulfadiazine  
  
Cattle  Muscle    
 
 12 days The Veterinary 
Formulary 6th ed.Yolande 
Bishop 6th ed 2005 pp.161  Milk  2 days 104 
   
Sulfadiazine  
spectrophotometric 
method   
Acta Pharm. 57 (2007) 
333–342  
10.2478/v10007 -007-
0026 -4 Sheep  Muscle  14 days 2007 The United States 
Pharmacopeial 
Convention  
Chicken  Muscle  7 days  The Veterinary 
Formulary 6th ed.Yolande 
Bishop 6th ed 2005 pp.161  
2.1.14.5. Sulfadimethoxine  
 
 Cattle  Muscle   
Sulfadimethoxine  
Liquid 
Chromatography  J AOAC Int.   
1995 May -
Jun;78(3):651 -8 7 days Drugs and Their Usage  
William D.Grimly 1998, 
pp. 141  Milk   
3 days 
Chicken  
 Muscle  5 days  AAMER et al. / Int. J. 
Agri. Biol., Vol. 2, No. 3, 
2000  
2.1.14.6. Sulfadimidine  
(Sulfamethazine)  
 
 Cattle  
 
 
 
 Muscle  
 
 
 
 
 
Sulfamethazine  
Liquid 
Chromatography   
 
 
 
 
 
J AOAC Int. 
1995 May -15 days 
 
 
 
 
18 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 143  
 
The Veterinary 
Formulary 6th ed.Yolande 
Bishop 6th ed 2005 pp.159  
 
Milk  3 days 
 
 
 
6.5 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 143  
 
The Veterinary 
Formulary 6th ed.Yolande 
Bishop 6th ed 2005 pp.159  105 
 Sheep  Muscle   Jun;78(3):651 -8 
 
 
 15 days 
 
 
 
18 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 143  
 
The Veterinary 
Formulary 6th ed.Yolande 
Bishop 6th ed 2005 pp.159  
 
Goat  Muscle  15 days Drugs and Their Usage  
William D.Grimly 1998  
pp. 143  
milk 3 days Drugs and Their Usage  
William D.Grimly 1998  
pp. 143  
2.1.14.7. Sulfadoxine  
 
 
 
 
 
 
 
 
 Cattle  
 
 
 Muscle   
Sulfadoxine  
 
Liquid 
Chromatography   
J. Anal. Chem., 365(5):  
444-447. 
 10 days 
 
 
14 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.161  
 
Dutch Farm International 
B.V.  
Industrieweg 14c – 1231 
KH Loosdrecht - Holland  
P.O. Box 63 – 1230 AB 
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  Milk  2 days 
 
 
 
4 days  106 
 2.1.14.8. 
Sulfaethoxypyridazine  
 Cattle  
 Muscle  Sulfaethoxypyridazin
e 
Liquid 
Chromatography  Berzas Nevado et al  
Analytica Chimica Acta 
442 (2001) 241 –248 16 days Veterinary Pharmacology 
and Toxicology, 
Roy,B.K. 1st ed. 2001. 
Pp.376  Milk  3 days 
2.1.14.9. Sulfaguanidine  
 Cattle  
 Muscle  Sulfaguanidine  
GC-MS Bulletin of the 
Veterinary Institute in 
Pulawy 55  :717-720  
ISSN:  0042 -4870   
10 days Adwia Pharmaceut.Co. 
Egypt  
 
2.1.14.10. Sulfamerazine  
 
  
 
 
 
 
 Cattle  
 
 
 Muscle   
Sulfamerazine  
 
UV 
spectrophotometry   
 
 
 
Ann Pharm  Fr.  
1978 Feb;36(9 -10):489 -
94 10 days 2007 The United States 
Pharmacopeial 
Convention  
Chicken  Muscle  14 days  
Turkey  Muscle  14 days  
 
2.1.14.11. Sulfanilamide  
 
 Cattle  
 Muscle  Sulfanilamide  
TLC  Journal of Liquid 
Chromatography  
Volume 9 , Issue 9 , 
1986  
Josep h 
Sherma  & Melinda 
Duncan  10 days 2007 The United States 
Pharmacopeial 
Convention  
Milk  4 days 2007 The United States 
Pharmacopeial 
Convention  107 
 2.1.14.12. Sulfanitran  
 
 Chicken  Muscle  Not established  - 5 days AAMER et al. / Int. J. 
Agri. Biol., Vol. 2, No. 3, 
2000  
 
www.ucsusa.org/assets/d
ocuments/.../hog_apps.pdf
  
2.1.14.13. Sulfapyridine  
 Cattle  
 
 Muscle  Not established  - 10 days 2007 The United States 
Pharmacopeial 
Convention  
Milk  4 days 2007 The United States 
Pharmacopeial 
Convention  
2.1.14.14. Sulfaquinoxaline  
 
 Cattle  Muscle   
Not established  
 
 
 
 
 
 
  
- 
 
 
 
 
 
 
 
 
 
 
 
 
 
 10 days AAMER et al. / Int. J. 
Agri. Biol., Vol. 2, No. 3, 
2000  
Chicken  Muscle  7 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.162  
Eggs  4 days  Dutch Farm International 
B.V.  
Industrieweg 14c – 1231 
KH Loosdrecht - Holland  
P.O. Box 63 – 1230 AB 
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 108 
   mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
Turkey  
 
 Muscle  9 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.162  
2.1.14.15. Sulfathiazole  
 
 
 Cattle  
 
 
 Muscle  Not established  - 10 days  
 
 
 
 
2007 The United States 
Pharmacopeial 
Convention  Milk  4 days 
Chicken  Muscle  14 days  
Turkey  Muscle  14 days  
2.1.15. TETRACYCLINES  
2.1.15.1. Chlortetracycline  
 
 
 Cattle  Muscle   
Sum of parent drug 
and its 4 - epimer  
 
High Performance 
Liquid 
Chromatography 
(HPLC )  
 
AOAC 995.09 
extension (Canada)  
 25 days  
 
The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.151  Chicken  
 Muscle  6 days  
Eggs  6 days  
Turkey  Muscle  3 days  
2.1.15.2. Doxycycline  
 Cattle  
 
 
 Muscle  
 Doxycycline  
High Performance 
Liquid Chromatographia  
1998 , Volume  47, Issue  
9-10, pp 547-549 3 days (10 
mg/kg)  
12 days (20 DIVASA -
FARMAVIC S.A.  
Ctra. Sant Hipòlit, 
km 71  109 
  
  
 
 Chromatography 
(HPLC ) 
 
 
  
 
 
 mg/kg)  08503 Gurb -Vic 
Barcelona (Spain)  
Poultry  
 Muscle  7 days  Dutch Farm International 
B.V.  
Industrieweg 14c – 1231 
KH Loosdrecht - Holland  
P.O. Box 63 – 1230 AB 
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
2.1.15.3. Oxytetracycline  
 
 Cattle  
 Muscle   
 
 
 
 
 
 
 
 
Sum of parent 
drugand its 4 -epimer  
 
Liquid 
Chromatography   
 
 
 
 
 
 
 
 
AOAC 995.09 
extension (Canada) 
 
 
 
 
 Oral 7 days 
 L.A. 50 days  
S.A.35 days  Food Animal Residue 
Avoidance & Depletion 
Program (FARAD) 
http://www.farad.org/eldu
/prohibit.html  
Milk  L.A. 192 h  
S.A. 144 h  Food Animal Residue 
Avoidance & Depletion 
Program (FARAD) 
http://www.farad.org/eldu
/prohibit.html  
 
Chicken  Muscle  3 days  
 
 
 AAMER et al. / Int. J. 
Agri. Biol., Vol. 2, No. 3, 
2000  
 110 
   
 
 
 
 
 
  
 
 
 
 
 
 
 
 
  
 7 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.153  
Eggs  1 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.153  
Turkey  Muscle  7 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.153  
Salmoni
ds 
Lobsters  Muscle  30 days  Phibro Animal Health  
2.1.15.4. Tetracycline  
 Cattle  
 Muscle   
 
 
 
Sum of parent 
drugand its 4-epimer  
 
Liquid 
Chromatography   
 
 
 
 
AOAC 995.09 
extension (Canada  
 10 days  
intrauterine   
 
Eurovet animal health  
Handelsweg 25  
NL-5531 AE BLADEL  
The Netherlands  
Tel. ++31 -497544300  
Fax ++31 -497544302  Milk  3 days  
 
 
 
 111 
 2.2.  RESIDUE DEFINITION, METHODS OF DTECTION AND WITHDRAWAL PEROIDS OF ANTIFUNGAL 
DRUGS  
 
Drug groups  Food commodity   
Residue 
Definition  
(Marker residue)  
and 
Method of 
detection  
(Technique)   
 
References  
  
 
Withdrawal period   
 
References  
 Species  Tissue 
or 
product  
2.2.1. Natamycin  
 Cattle  Edible 
tissues   
 
 
not established   
 
- Zero  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 
2005 pp.395  
2.2.2. Nystatin  
 
 Cattle  Edible 
tissues  7 days  Vetoquinol 
Co.France  
 
 
 
 
 
 
 112 
 2.3. RESIDUE DEFINITION, METHODS OF DTECTION AND WITHDRAWAL PEROIDS   OF 
ANTIPARASITIC DRUGS  
2.3.1.  Residue definition, Methods of detection and Withdrawal period of Anticoccidial drugs  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of 
detection  
(Technique)   
 
References  
  
 
Withdrawal period   
 
References  
 Species  Tissue or 
product  
2.3.1.1. Amprolium  
 
 Cattle  Muscle   
 
 
 
not established   
 
 
 
- 
 
 
 
 1 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 107  
Chicken  Muscle  Zero  Global Vet Health S.L.  
C/Capçanes  
Nº12 -bajos  
Polígon Agro -Reus.  
Reus 43206  
SPAIN  
 
Eggs  Zero  Global Vet Health S.L.  
C/Capçanes  
Nº12 -bajos  
Polígon Agro -Reus.  
Reus 43206  
SPAIN  113 
 Turkey  Muscle  Zero  Global Vet Health S.L.  
C/Capçanes  
Nº12 -bajos  
Polígon Agro -Reus.  
Reus 43206  
SPAIN  
2.3.1.2. Clazuril  Pigeon  Muscle  not established  - Not used for human 
consumption  Harkers Limited  
Unit 2,  
Cavendish Road  
Bury St . 
dmunds  Suffolk  
IP33 3TE  
2.3.1.3. Clopidol  
 Chicken  Muscle  Clopidol  
Liquid 
Chromatography  Pang GF, Cao YZ, 
Fan CL, Zhang  JJ, Li 
XM, MacNeil JD.( 
2003) Determination 
of clopidol residues 
in chicken tissues by 
liquid 
chromatography: 
collaborative  study. J 
AOAC Int  
.;86(4):685 -93. 5 days  Modern livestock and 
poultry production,7th 
ed. James R.Gillespie, 
2004, pp.156  
2.3.1.4. Decoquinate  
 
 
 Cattle  Muscle  not established  - 1 day  J.D.G. McEvoy / 
Analytica Chimica Acta 
473 (2002) 3 –26 Goat  Muscle  not established  - 1 day  
Chicken  
 Muscle  not established  - 3 days  
2.3.1.5. Diclazuril  
 Sheep  Muscle  not established  - Zero  J.D.G. McEvoy / 
Analytica Chimica Acta 114 
  473 (2002) 3 –26 
Poultry  Muscle  not established  - 5 days  J.D.G. McEvoy / 
Analytica Chimica Acta 
473 (2002) 3 –26 
2.3.1.6. 
Dinitolmide(Zoalene)  
 Chicken  Muscle  Sum of dinitolmide 
and its metabolite 3 -
amino -5-nitro-o -
toluamide, expressed 
as dinitolmide 
equivalents  
 
Spectrophotometric  
 
 
 Analytical Methods 
Committee(1969)  
The determination of 
dinitolmide (zoalene) 
in animal feeds  
Analyst , ,94: 1159 -
1163  
 3 days  J.D.G. McEvoy / 
Analytica Chimica Acta 
473 (2002) 3 –26 
Turkey   Zero  Canadian Food 
Inspection Agency.59 
Camelot 
Drive,Ottawa,Ontario,C
ANADA, KIA 0Y9  
2.3.1.7. Ethopa bate 
 
 
Chicken  Muscle  Ethopapate  
Liquid 
Chromatography  Nagata T, Saeki M, 
Nakazawa H, Fujita 
M, Takabatake E. 
(1985) Sensitive 
determination  
of ethopabate 
residues in chicken 
tissues by liquid 
chromatography 
with fluorometric 
detection. J Assoc 
Off Anal 5 days  Modern Livestock& 
Poultry Production 7th 
ed. James R.Gillespie 
2004,pp.156  115 
 Chem.;68(1):27 -8 
2.3.1.8. Halofuginone  
hydrobromide  
 
 Cattle  
 
 Muscle   
Halofuginone  Halofuginone  
 
HPLC  Kinabo LD, 
McKellar QA, 
Murray M. (1989) 
Determination of 
halofuginone in 
bovine  plasma by 
competing -ion high 
performance liquid 
chromatography 
after solid phase  
extraction. Biomed 
Chromatogr.  
;3(3):136 -8. 13 days  J.D.G. McEvoy / 
Analytica Chimica Acta 
473 (2002) 3 –26 
Chicken  Muscle  5 days  J.D.G. McEvoy / 
Analytica Chimica Acta 
473 (2002) 3 –26 
2.3.1.9. Lasalocid Sodium  
 
 
 
 
 
 
 Cattle  Muscle  Lasalocid A  
 
Liquid 
Chromatography  Tkáčiková S, 
Kožárová I, 
Mačanga J, Levkut 
M.( 2012) 
Determination of 
lasalocid  residues in 
the tissues of broiler 
chickens by liquid 
chromatography -
tandem mass  
spectrometry. Food 
Addit Contam Part A 
Chem Anal Control 
Expo Risk Assess.  
;29(5):761 -9. Zero  Ridley Block 
Operations  
Sheep  Muscle  Zero  Ridley Block 
Operations  
Goat  Muscle  Zero  Ridley Block 
Operations  
Chicken  Muscle  5 days  J.D.G. McEvoy / 
Analytica Chimica 
Acta 473 (2002) 3 –
26 
2.3.1.10. Maduramicin 
ammonium  
 
 Chicken  
 Muscle  Maduramicin  
 Maduramicin  
Liquid Johnson NA.(1989) 
Determination of 
maduramicin by 
liquid 5 days  J.D.G. McEvoy / 
Analytica Chimica Acta 
473 (2002) 3 –26 116 
 Chromatography  chromatography 
with atomic  
absorption 
spectrometric 
detection. J Assoc 
Off Anal Chem. 
1989  ;72(2):235 -7. 
2.3.1.11. Methyl  
benzoquate  
 
 Chicken  Muscle  Methyl benzoquate  
High Performance 
Liquid 
Chromatography 
(HPLC ) 
 George H. J. 
Merson  ,  Lesley A. 
Hill and Steven F. 
Johnson(1985)  
Determination of 
methyl benzoquate 
in poultry 
feedingstuffs using 
high-performance 
liquid 
chromatography  
Analyst , ,110, 761 -
764 5 days  J.D.G. McEvoy / 
Analytica Chimica Acta 
473 (2002) 3 –26 
2.3.1.12. Monensin  
 
 
 Cattle  Muscle  Monensin  A 
 
LC-MS Wenlu Song  
Min Huangy  
Wilson Rumbeiha  
and Hui Li(2007)  
Determination of 
amprolium, Zero  Elanco Animal Health  
Sheep  Muscle   Zero  
Goat  Muscle  Zero  117 
 Chicken  
 Muscle  carbadox, monensin, 
and tylosin in 
surface water by 
liquid 
chromatography/  
tandem mass 
spectrometry  
Rapid Commun.  
 Mass Spectrom. 
2007; 21: 1944 –
1950  3 days  J.D.G. McEvoy /  
Analytica Chimica Acta 
473 (2002) 3 –26 Chicken  
 Muscle  5 days  
2.3.1.1 3. Narasin  Chicken  Muscle  Narasin  COMPENDIUM OF 
METHODS OF 
ANALYSIS  5 days  J.D.G. McEvoy / 
Analytica Chimica Acta 
473 (2002) 3 –26 
2.3.1.14. Nicarbazin  Chicken  
 
 Muscle  4,4′-
dinitrocarbanilide 
(DNC)  
LC  Guglielmo Dusi, 
Elena Faggionato, 
Valentina Gamba, 
Alessandro 
Baiguera  (2000)  
Determination of 
nicarbazin and 
clopidol in poultry 
feeds by liquid 
chromatography     
Journal of 
Chromatography A, 
Volume 882, ( 1 –2,)  
79-84  
 9 days  J.D.G. McEvoy / 
Analytica Chimica Acta 
473 (2002) 3 –26 
2.3.1.15. Ormetoprim  Salmonids  muscles  not established  - 42 days  Aquatic Health 118 
  
 Cat fish  3 days  Resources,USA  
 
Chickens  Muscles  5 days  Modern Livestock& 
Poultry Production 7th 
ed. James R.Gillespie 
2004, pp.156   
Turkeys  Muscles  5 days  
2.3.1.16. Robenidine  
hydrochloride  
 
 
 
 
 
 
 
 
 
 
 Chicken  
 
 
 
 
 
 
 Muscle  Robenidine  
LC 
 
 
 
 
 
 Geraldine Dowling, 
Michael O’Keeffe, 
Malcolm R. 
Smyth(2005)   
Determination of 
robenidine in eggs 
by liquid 
chromatography 
with UV 
spectrophotometric 
detection     
Analytica Chimica 
Acta, Volume 539, ( 
1–2, ), 31 -34  5 days  J.D.G. McEvoy / 
Analytica Chimica Acta 
473 (2002) 3 –26 119 
 2.3.1.1 7. Salinomycin 
Sodium  
 Chicken  Muscle  Salinomycin  
HPLC  Arun Kumar 
Mathur  (1994)  
Determination of 
salinomycin by high -
performance liquid 
chromatography 
using a precolumn 
derivatization 
technique  
Journal of 
Chromatography A, 
Volume 664, ( 2), 
284-288  5 days  J.D.G. McEvoy / 
Analytica Chimica Acta 
473 (2002) 3 –26 
2.3.1.18. Semduramicin  
 
 Chicken  
 Muscle  
 Semduramicin  
LC María José González 
de la Huebra, Ursula 
Vincent, Christoph 
von Holst  (2010)  
Determination of 
semduramicin in 
poultry feed at 
authorized level by 
liquid 
chromatography 
single quadrupole 
mass spectrometry    
Journal of 
Pharmaceutical and 
Biomedical 
Analysis, Volume 
53, ( 4) 860 -868  5 days  J.D.G. McEvoy / 
Analytica Chimica Acta 
473 (2002) 3 –26 
10 days  The Veterinary 
Formulary 6th ed. 
Yolande Bishop 6th ed 
2005 pp.176  120 
 Eggs  not established  - Not established  Bayer plc,  
Animal Health 
Division,  Bayer 
House,  
Strawberry Hill,  
Newbury,  
Berkshire RG14 
1JA 
 
 
2.3.2.  Residue definition, Method of detection and withdrawal periods of Anthelmintic agents  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of detection  
(Technique)   
 
References  
  
 
Withdrawal 
period   
 
References  
 Species  Tissue 
or 
product  
2.3.2.1. Abamectin  
   
Cattle  Muscle  Avermectin B1a  
 
LC-MS/MS  Inoue K, Yoshimi Y, 
Hino T, Oka  H.(2009) 
Simultaneous 
determination of 
avermectins  
in bovine tissues by 
LC-MS/MS. J Sep 
Sci. 2009 
Nov;32(21):3596 -602 42 days  The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.187  121 
  
2.3.2.2. Albendazole  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 Cattle  
 
 
 
 
 
 Muscle  Sum of albendazole 
sulphoxide, albendazole 
sulphone, and 
albendazole 2 -amino 
sulphone, expressed as 
albendazole.  
capillary 
electrophoresis  
 
 
 
 
 
 
 
 
 
 
 
 Procházková A, 
Chouki M, Theurillat 
R, Thormann 
W.(2000) Therapeutic 
drug monitoring  
of albendazole: 
determination of 
albendazole, 
albendazole sulfoxide, 
and 
albendazole sulfone in 
human plasma using 
nonaqueous capillary 
electrophoresis.  
Electrophoresis. 
21(4):729 -36. 
 
 
 
 
 
 
 
 
 
 
 
 
 27 days  
 
 
20 days  
 Drugs and Their Usage  
William D.Grimly 1998  
pp. 107 
The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.191  
Milk  3 days  Dutch Farm International 
B.V.  Industrieweg 14c – 
1231 KH Loosdrecht – 
Holland , P.O. Box 63 – 
1230 AB Loosdrecht - 
Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
Sheep  Muscle  8 days  The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.1 91 
 
Goat  
 Muscle  8 days  Dutch Farm International 
B.V. Industrieweg 14c – 
1231 KH Loosdrecht  – 
Holland, P.O. Box 63 – 
1230 AB Loosdrecht - 122 
  
  
 
 
 
 
 
 Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
Milk  3 days  Dutch Farm International 
B.V. Industrieweg 14c – 
1231 KH Loosdrecht – 
Holland, P.O. Box 63 – 
1230 AB Loosdrecht - 
Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
2.3.2.3. Avermectin  
(abamectin)  Cattle  Muscle  22, 23 -Dihydro -
avermectin B1a  
HPLC  GONG Xiaoming, 
SUN Jun, DONG 
Jing, YU Jinling, 
WANG 
Hongtao (2011)  
Determination of 
avermectin, diclazuril, 
toltrazuril and 
metabolite residues in   123 
 pork by high 
performance liquid 
chromatography -
tandem mass 
spectrometry  
Chinese Journal of 
Chromatography   20
11, Vol. 29  Issue 
(3): 217 -222     
2.3.2.4. Closantel  
 
 
 
 
 
 Cattle  Muscle  
Closantel  
HPLC  
 
 
 Sun HW, Wang FC, 
Ai LF.( 2008) 
Determination of 
closantel residues in 
milk and animal  
tissues by HPLC with 
fluorescence detection 
and SPE with oasis 
MAX cartridges. J  
Chromatogr Sci. 
Apr;46(4):351 -5. 28 days  
 
 Drugs and Their Usage  
William D.Grimly 1998  
pp. 108  
Blacks Veterinary 
Dictionary ,Edward 
Boden,19TH ED.1998  
Sheep  
 Muscle  42 days  Blacks Veterinary 
Dictionary ,Edward 
Boden,19TH ED.1998  
 2.3.2.5. Derquantel  
 
 Sheep  Muscle  Derquantel  
 
HPLC  Australian Pesticides 
& Veterinary 
Medicines Authority  
Application Summary 
for Application No 
47910  14 days  Pfizer Ltd , Ramsgate 
Road  
Sandwich  Kent  CT13 9NJ  
124 
 2.3.2.6. Doramectin  
 
 
 
 
 
 Cattle  Muscle  Doramectin  
LC  
 
 
 
 
 Ali MS, Sun T, 
McLeroy  GE, 
Phillippo  ET.(2000)  
Simultaneous  
determination  of 
eprinomectin,  
moxidectin,  
abamectin,  
doramectin,  and 
ivermectin  in beef 
liver by  
LC with fluorescence  
detection.  J AOAC  
Int. 83(1):31 -8. 56 days  
 
 
 
Pour -on 35 days  The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.1 87 
 
The Veterinary 
Formulary  6th 
ed.Yolande Bishop 6th ed 
2005 pp.1 88 
Sheep  Muscle  63 days  
 
 
70 days  
 Blacks Veterinary 
Dictionary ,Edward 
Boden,19TH ED.1998  
The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.187  
2.3.2.7. Eprinomectin  
 Cattle  
 
 Muscle  Eprinomectin B1a  
 
HPLC  Sutra JF, Chartier C, 
Galtier P, Alvinerie 
M.(1998) 
Determination of 
eprinomectin in  
plasma by high -
performance liquid 
chromatography with 
automated solid phase  
extraction and 15 days pour -on The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.1 88 Milk  Zero  125 
 fluorescence 
detection. Analyst. 
123(7):1525 -7. 
2.3.2.8. 
Febantel/Fenbendazole  
 
 
 
 
 
 
 
 
 
 
 
 
 Cattle  Muscle  Sum of 
extractableresidues 
which maybe oxidised 
tooxfendazole sulphone  
HPLC  
 
 
 
 
 
 
 
 
 
 
 
 György Morovján, 
Peter Csokán, László 
Makransz(1998)  
 Determination of 
fenbendazole, 
praziquantel and 
pyrantel pamoate in 
dog plasma by high -
performance liquid 
chromatography    Jour
nal of 
Chromatography A, 
Volume 797, (1 –2), 
27, 237 -244  
 
 
 
 
 
 Febantel 35 days  
Fenbendazole 
14 days 
 
 
Fenbendazole   
28 days   
Drugs and Their Usage  
William D.Grimly 1998  
pp. 111  
 
The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.192  
Milk  4 days  
 
 
 
3 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 111  
 
The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.192  
Sheep  Muscle  15 days  Blacks Veterinary 
Dictionary ,Edward 
Boden,19TH ED.1998  
The Veterinary milk 7 days  126 
   
 Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.192  
Goat  
 Muscle  14 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 1 11 milk 1 days  
2.3.2.9. Flubendazole  
 Chicken  
 
 Muscle  Sum of 
flubendazoleand (2 -
amino 1H -
benzimidazol -5-
yl)(4fluorophenyl)meth
anone  
HPLC  György Morovján, 
Peter Csokán, László 
Makransz(1998)  
 Determination of 
fenbendazole, 
praziquantel and 
pyrantel pamoate in 
dog plasma by high -
performance liquid 
chromatography    Jour
nal of 
Chromatography A, 
Volume 797, (1 –2), 
27, 237 -244  
 7 days The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.1 93 eggs Zero  
2.3.2.10. Ivermectin  
 
 
  
Cattle  
 Muscle  
22, 23 -Dihydro -
avermectin B1a  
HPLC  
 Patricia C. 
Tway  , James S. 
Wood  Jr., George V. 
Downi ng(1981)  
Determination of 49 days 
 
14 days oral  Drugs and Their Usage  
William D.Grimly 1998  
pp. 112  
Dutch Farm International 
B.V.  Industrieweg 14c – 
1231 KH Loosdrecht – 127 
  
 
  
 
 
 
 ivermectin in cattle 
and sheep tissues 
using high -
performance liquid 
chromatography with 
fluorescence detection  
J. Agric. Food 
Chem.,  , 29 (5), 1059 –
1063  Holland , P.O. Box 63 – 
1230 AB Loosdrecht - 
Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
 
 
Sheep  Muscle  42 days S.C.  
 
 
10 days oral  Blacks Veterinary 
Dictionary ,Edward 
Boden,19TH ED.1998  
Dutch Farm International 
B.V.  Industrieweg 14c – 
1231 KH Loosdrecht – 
Holland , P.O. Box 63 – 
1230 AB Loosdrecht - 
Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
2.3.2.11. Levamisole  
 Cattle  
 Muscle   
  
 
R.Woestenborghs, L. 28 days  The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 128 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 Levamisole  
GC 
 
 
 
 
 Michielsen, J. 
Heykant (1981)  
Determination of 
levamisole in plasma 
and animal tissues by 
gas chromatography 
with thermionic 
specific detection    
Journal of 
Chromatography B: 
Biomedical Sciences 
and Applications, 
Volume 224, (1) 25 -
32  2005 pp.1 95 
 Milk  4 days  Dutch Farm International 
B.V.  
Industrieweg 14c – 1231 
KH Loosdrecht - Holland  
P.O. Box 63 – 1230 AB 
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
Sheep  
 Muscle  21 days 
 
 
28 days  Blacks Veterinary 
Dictionary ,Edward 
Boden,19TH ED.1998  
The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.195  
Chicken  
 Muscle  16 days  Dutch Farm International 
B.V.  Industrieweg 14c – 
1231 KH Loosdrecht – 
Holland , P.O. Box 63 – 
1230 AB Loosdrecht - 
Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  Eggs  4 days  129 
 M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
2.3.2.12. Mebendazol e 
 Sheep  
 Muscle  Sum of 
mebendazolemethyl (5 -
(1-hydroxy, 1-
phenyl)methyl -1H-
benzimidazol -2-
yl)carbamate and(2 -
amino -1H-
benzimidazol -5-
yl)phenylmethanone,ex
pressed asmebendazole 
equivalents  
HPLC   Juan José Garcia   
Francisco Bolás -
Fernández  
Juan José 
Torrado (1999)  
Quantitative 
determination of 
albendazole and its 
main me tabolites in 
plasma  
Journal of 
Chromatography B: 
Biomedical Sciences 
and Applicatio ns 
Volume 723, Issues 
(1–2), 265 –27 7 days  
 
 
 
14 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 114  
 
The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.193  
2.3.2.13. Monepantel  
 Cattle  Muscle  Monepantel -sulfone  
HPLC -MS/MS  Kinsella B, Byrne P, 
Cantwell H, 
McCormack M, Furey 30 days   
 
 Milk  Zero USA  130 
  
 
 
 A, Danaher M. (2011)  
Determination of the 
new anthelmintic 
monepantel and its 
sulfone metabolite in  
milk and muscle using 
a UHPLC -MS/MS 
and QuEChERS 
method. J Chromatogr 
B Analyt  
Technol Biomed Life 
Sci. 1;879(31):3707 -
13. 14 days Canada  Drugs and Their Usage  
William D.Grimly 1998  
pp. 114  
Sheep  
 
 Muscle  30 days  
2.3.2.14. Moxidectin  
 
 Cattle  
 Muscle   
 
 
Moxidectin  
LC-MS Khunachak A, 
Dacunha AR, Stout 
SJ.( 1993) Liquid 
chromatographic 
determination of  
moxidectin residues in 
cattle tissues and 
confirmation in cattle 
fat by liquid  
chromatography/mass 
spectrometry J AOAC 
Int. 76(6):1230 -5 65 days ( s/c)  The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.1 89 
Sheep  Muscle  Oral 14 days  
Injection 70 
days 
Goats  Muscle  14 (oral 0.2 
mg/kg)  
23 (oral 0.5 
mg/kg)  Drugs and Their Usage  
William D.Grimly 1998  
pp. 135  
2.3.2.15. Nitobimin  
 Cattle  
 Muscle  Nitobimin  
LC Ramadan NK, 
Mohamed AO, 
Shawky SE, Salem 10 days   
 
Drugs and Their Usage  Milk  3 days  131 
  
 
 
 
 
 
 
  
 
 
 
  
 
 
 MY.(2012) Different 
stability -indicating  
chromatographic 
techniques for the 
determination of 
netobimin. J Anal 
Methods  
Chem.;2012:754650.  
doi:  10.1155/2012/75
4650  William D.Grimly 1998  
pp. 135  
 
 
 
Sheep  Muscle  5 days  
Milk  3 days  
2.3.2.16. Nitroxynil  
 
 
 
 
 
 Cattle  Muscle   
 
Nitroxynil  
 
GC 1. M. J. Parnell(1970)  
Determination of 
nitroxynil residues in 
sheep and calves  
Pesticide  Science  
Volume  1, ( 4,) 138–
143,   49 days  
 
 
60 days   
Blacks Veterinary 
Dictionary ,Edward 
Boden,19TH ED.1998  
 
The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.199  Merial Co.  Sheep  
 Muscle  49 days  
 
 
60 days  
2.3.2.17. Oxfendazole  
 
 Cattle  Muscle  Sum of 
extractableresidues 
which maybe oxidised 
tooxfendazole sulphone  Tsina IW, Matin 
SB.(1981) 
Determination of 
oxfendazole in cow 
milk by reversed -7 days  Boehringer Ingelheim  
Sheep  
 Muscle  24 days  Blacks Veterinary 
Dictionary ,Edward 132 
 HPLC  phase  
high-performance 
liquid 
chromatography. J 
Pharm Sci. 70(8):858 -
60. Boden,19TH ED.1998  
2.3.2.18. Oxyclozanide  
 Cattle  Muscle  Oxyclozanide  
HPLC  Jo K, Cho HJ, Yi H, 
Cho SM, Park JA, 
Kwon CH, Park HR, 
Kwon KS, Shin 
HC.(2011)  
Determination of 
Oxyclozanide in Beef 
and Milk  using High -
Performance Liquid  
Chromatography 
System with UV 
Detector. Lab 
AnimRes;27(1):37 -40.  14 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 1 17 Milk  Zero  
 
2.3.2.19. Piperazine  
 Chicken  eggs  
 
 
Piperazine  
HPLC  
 Renata 
Gadzała‐Kopciuch (20
05) Accurate HPLC 
Determination of 
Piper azine Residues in 
the Presence of other 
Secondary and 
Primary Amines  
 4 days  Dutch Farm International 
B.V.  
Industrieweg 14c – 1231 
KH Loosdrecht - Holland  
P.O. Box 63 – 1230 AB 
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet   Muscle  8 days  133 
  Journal of Liquid 
Chromatography & 
Related Technologies  
Volume 28 , Issue 14 , 
2005  (ONLINE )  
DOI: 10.1081/JLC200
064156  www.dutchfarmint.com  
 Cattle  Muscle  8 days  Dutch Farm International 
B.V.  
Industrieweg 14c – 1231 
KH Loosdrecht - Holland  
P.O. Box 63 – 1230 AB 
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
  Milk    4 days  Dutch Farm International 
B.V.  Industrieweg 14c – 
1231 KH Loosdrecht – 
Holland , P.O. Box 63 – 
1230 AB Loosdrecht - 
Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
2.3.2.20. Praz iquantel  
  
Sheep  Muscle  Prazequantel  CVMP Summary 
Report 
EMEA/MRL/867/03, 28 days  Merial Animal Health 
Ltd PO Box 327  
Sandringham House , 134 
 (1998),  Harlow Business Park , 
Harlow  Essex  CM19 
5TG 
2.3.2.21. Rafoxanide  
 
 Cattle  Muscle  Rafoxanide  
HPLC  Benchaoui HA, 
McKellar QA.( 1993) 
Determination of 
rafoxanide and 
closantel in ovine  
plasma by high 
performance liquid 
chromatography. 
Biomed Chromatogr.  
7(4):181 -3. 28 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 120  
2.3.2.22. Thiabendazole  
 
 
 
 
 
 
 Cattle  
 Muscle  Sum of 
thiabendazoleand 
5hydroxythiabendazole  
LC  Cannavan A.;  Haggan 
S.A.;  Glenn Kennedy 
D.(1998)  
Simultaneous 
determination of 
thiabendazole and its 
major metabolite, 5 -
hydroxythiabendazole, 
in bovine tissues using 
gradient liquid 
chromatography with 
thermospray and 
atmospheric pressure 
chemical ionisation 
mass spectrometry  
 
J.ChromatographyB:  30 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 120  
Milk  4 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 120 
Goat  Muscle  30 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 120  
Sheep  Muscle  30 days  Drugs and Their Usage  
William D.Grimly 1998  
pp. 120  135 
 718, Issue 1 , 23 
October 1998, 103 –
113 
2.3.2.23. 
Triclabendazole  
  
 Cattle  
 
 Muscle  Sum of 
extractableresidues 
which maybe oxidised 
to ketotriclabendazole  
HPLC  Kazue Takeba , 
Kenji Fujinuma   
Miho Sakamoto ,  
TomoyukiMiyazaki , 
Hisao O ka,  
Yuko Itoh Hiroyuki 
Nakazawa (2000)  
Simultaneous 
determination of 
triclabendazole and its 
sulphoxide and 
sulphone metabolites 
in bovine milk by  
high-performance 
liquid chromatography  
 
J.Chromatography,  
Volume 882, Issues 
1–2, 2000, Pages 99 –
107 56 days  The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th ed 
2005 pp.199  
Sheep  Muscle  56 days  Blacks Veterinary 
Dictionary ,Edward 
Boden,19TH ED.1998  
 
 136 
  
2.3.3.  Residue definition, Method of detection and withdrawal periods of Antiprotozoal drugs  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of 
detection  
(Technique)   
 
References  
  
 
Withdraw
al period   
 
References  
 Species  Tissue 
or 
product  
2.3.3.1.  Diminazene  
 
 Cattle  
 
 Muscle  Diminazene  
 
LC José e. Roybal, 
Allen p. Pfenning, 
Josephm. Storey, 
steve a. gonzales, 
and Sherrib. 
Turnipseed(2003)  
Liquid 
Chromatographic 
Determination of 
DiminazeneDiacetu
rate (Berenil)in 
Raw Bovine Milk  
Journal of AOAC 
InternationaL. 86,. 
5, 930 -934 21 days  Dutch Farm International 
B.V.  
Industrieweg 14c – 1231 
KH Loosdrecht - Holland  
P.O. Box 63 – 1230 AB 
Loosdrecht - Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  
E-mail: 
mail@du tchfarmint.com  
Internet 
www.dutchfarmint.com  
Milk  3 days  Dutch Farm International 
B.V.  Industrieweg 14c – 
1231 KH Loosdrecht – 
Holland , P.O. Box 63 – 
1230 AB Loosdrecht - 
Holland  
T: +31 35 5821220 - F: 
+31 35 5822224  
M : +31 6 53 86 88 53  137 
 E-mail: 
mail@dutchfarmint.com  
Internet 
www.dutchfarmint.com  
2.3.3.2.Imidocarb  
 Cattle  
 Muscle  Imidocarb  
LC KoichiInoue a, Mari
Nunome b, Tomoak
iHino a & Hisao 
Okaab (2011)  
Journal of Liquid 
Chromatography & 
Related 
Technologies  
Volume 34 , Issue 
18, 2149 -2156  
(EMEA),  213 days  The Veterinary Formulary 
6th ed.Yolande Bishop 6th 
ed 2005 pp.177  
Milk  21 days  The Veterinary Formulary 
6th ed.Yolande Bishop 6th 
ed 2005 pp.177  
2.3.3.3.  Isometamidium  
 Cattle  
 Muscle   
 
 
Isometamidium  
HPLC  Perschke 
H, Vollner L (1985)  
Determination of 
the trypanocidal 
drugs homidium, 
isometamidium and 
quinapyramine in 
bovine serum or 
plasma using 
HPLC.  Acta 
Tropica  [1985, 
42(3):209 -216 30 days  Genevet limited  
Encyclopedic Reference of 
Parasitology:Diseases,Trea
tment,Therapy Vol.2, 
Philip M. Armstrong, 
Heinz Mehilhorn 2001,pp.  
 622. 
 Milk  Zero  Genevet limited  
 
 
 138 
 2.3.4.  Residue definition, Method of detection and withdrawal periods of  Ectoparasiticides  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of 
detection  
(Technique)   
 
References  
  
 
Withdrawal 
period   
 
References  
 Species  Tissue or 
product  
2.3.4.1.  Amitraz  
 
 
 
 Cattle  Muscle   
 
 
 
Sum of amitraz 
andall metabolites 
containing the 2,4 -
DMAmoiety, 
expressed as 
amitraz  
 
GC   M.E.C.  Queiroz   
 C.A.A.  Valadão   
 A. Farias  D. 
Carvalho F.M.  Lanças  
(2003)  Determination of 
amitraz in canine plasma 
by solid -phase 
microextraction –gas 
chromatography with 
thermionic specific 
detection  
J.Chromatography B  
Volume 794, (2 ) 337 –
342  
4 days   
 
 
 
 
The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th 
ed 2005 pp.208  Milk  
Sheep  Meat   
1 days  Goat Meat  
2.3.4.2.  Cyfluthrin  
 
 
 Cattle  
 Muscle  
Cyfluthrin (sum 
ofisomers  
LC FAO/WHO Specification 
385/TC (November 2004  
FAO SPECIFICATIONS 
AND EVALUATIONS  
FOR CYFLUTHRIN  1 day  Bayer, Bayer Cross, 
CyLence and Tempo 
are registered 
trademarks of Bayer 
AG, used under 
license by Bayer Inc  Milk  Zero  139 
 Page 1 -22  
2.3.4.3.  Cyhalothrin  
 Cattle  Muscle  Cyhalothrin (sum 
of isomers ) 
HPLC  
Denise Zuccari 
Bissacot  and Igor 
Vassili eff(1997)  
HPLC Determination of 
Flumethrin, 
Deltamethrin, 
Cypermethrin,  and 
Cyhalothrin Residues in 
the Milk and Blood of 
Lactating Dairy Cows  
Journal  of Analytical  
Toxicolog y 21 : 397-402  42 days  Encyclopedia of 
Parasitology, vol. 1 -2 
Heinz Mehlhorn , 3ed  , 
pp.378  
2.3.4.4.  Cypermethrin  
 
 
 
 
 
 
 
 
 Cattle  
 Muscle  
Cypermethrin  (sum 
of isomers)  
HPLC  28 days  
 pour-on The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th 
ed 2005 pp.213  
Milk  zero The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th 
ed 2005 pp.213  
Sheep  Muscle  8 days  
 Novartis Animal  
Health UK Limited  
Frimley Business  ark 
Frimley  Camberley  
Surrey  GU16 7SR  
United Kingdom  
Chicken  muscle  21 days   
The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th 
ed 2005 pp.213   eggs Zero  
2.3.4.5.  Cyromazine  
 
 Sheep  Muscle  Cyromazine  
 
HPLC  Ruicheng Wei Ran 
Wang , Qingfei Zeng ,  
Ming Chen  and Tiezheng 
Liu (2009)  High -28 days  Blacks Veterinary 
Dictionary ,Edward 
Boden,19TH ED.1998  140 
 Performa nce Liquid 
Chromatographic 
Method for the 
Determination of 
Cyromazine and 
Melamine Residues in 
Milk and Pork  Journal  of 
Chromatographic  
Science  Volume  47, ( 7) 
 . 581-584. 
2.3.4.6.  Deltamethrin  
 
 
 
 
 
 
 Cattle  
 
 Muscle   
Metabolite 3 -
phenoxybenzoic 
acid 
HPLC  
  Yan Ding ,  Catherine  A. 
White , S. Muralidhara ,  
 James  Bruckner ,  
 Michael  G. Bartlett  
(2004) Determination of 
deltamethrin and its 
metabolite 3 -
phenoxybenzoic acid in 
male rat plasma by high -
performance liquid 
chromatography  
J.Chromatography 
B:810(2) 221 -227 
 
 20 days  The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th 
ed 2005 pp.214  
Milk  Zero  The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th 
ed 2005 pp.214  
Sheep  
 Muscle  7 days  The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th 
ed 2005 pp.214  
Sheep  Muscle  35 days  
 
 
 
 
 
70 days  The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th 
ed 2005 pp.211  
An  imax Ltd , 
Shepherds  Grove  
West  Stanton  Bury St 
Edmunds  Suffolk  
IP31 2AR  
 141 
 2.3.4. 7.  Diazinon  
 Sheep  Muscle   
 
 
Diazinon  
GC  
 
 
 
 
 
COMMISSION 
REGULATION (EU) No 
37/2010   
35 days  
 
 
 
 
 
70 days   
The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th 
ed 2005 pp.211  
 
An imax Ltd 
Shepherds Grove 
West Stanton Bury St 
Edmunds Suffolk  
IP31 2AR  
2.3.4.8.  Dicyclanil  
 Sheep  
 Muscle  Sum of 
dicyclaniland 2, 4, 
6-triamino -
pyrimidine -5-
carbonitrile  
 
Sum of 
dicyclaniland 2, 4, 
6-triamino -
pyrimidine -5-
carbonitrile  
HPLC  COMMISSION 
REGULATION (EU) No 
37/2010  40 days  The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th 
ed 2005 pp.217  
2.3.4.9.  Emamectin  
 
 Cattle  
 Muscle   
  
 
 
 
 Zero  Intervet UK Ltd. 
Walton  Milton 
Keynes, Bucks.  
MK7 7AJ  142 
 Salmonids  Muscle  Emamectin B1a  
Not applicable  
  
- Norway 17.5 
at 100C 
USA 60 days  Schering Plough 
Animal Health  
2.3.4.10.  Fluazuron  
 
 Cattle  
 Muscle  Fluazuron  
LC COMMISSION 
REGULATION (EU) No 
37/2010  42 days  
Don’t 
slaughter 
calves  
younger than 
10 months  
suckling on 
treated dams  Novartis Animal 
Health: A business 
unit of Novartis South 
Africa (Pty) Ltd. 
(Company Reg. No.: 
1946/020671/07). P. 
O. Box 92, Isando, 
1600. Tel.: (011) 929 
2387. Email: 
infosa.ahzais@novarti
s.com. (FABE 
15/11/08)  
2.3.4.11.   Permethrin  
 
 
 
 Cattle  
 
 
 
 Muscle  Permethrin  
(sum of  isomers ) 
LC COMMISSION 
REGULATION (EU) No 
37/2010  Zero  
Pour - on 3 
days  
The Veterinary 
Formulary 6th 
ed.Yolande Bishop 6th 
ed 2005 pp.214  Milk  Zero  
 
Pour - on 6h  
2. 3.4.12.  Phoxim  
 
 Sheep  Muscle  Phoxim  
Not established  JECFA Evaluation: 52 
(1999); 62 (2004)  28 days  www.  WeiKu.com  
 Milk  3 days  
2.3.4.13.  Teflubenzuron  
 Salmonids  Muscle   
Not established   
 7 days  Trouw (UK) Limited  
Wincham  Northwich  143 
 - Cheshire  CW9 6DF  
2.3.4.14.  Trichlorfon 
(metrifonate)  
 Cattle  
 Milk Metrifonate   
GC CAC/MRL 2 -2012  Pour -on 21 
days Drugs and Their 
Usage  
William D.Grimly 
1998  pp. 121  
 
 
 
 
 
 
 
 
 
 
 
 
 144 
 2.4.  RESIDUE DEFINITION, METHODS OF DTECTION AND WITHDRAWAL PEROIDS OF ANTI -
INFLAMMATORIES (AI)  
2.4.1.  Residue definition, Method of detection and withdrawal periods of Non  Steroidal AI  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of 
detection  
(Technique)   
 
References  
  
 
Withdrawal 
period   
 
References  
 Species  Tissue 
or 
product  
2.4.1.1. Carprofen  
 
 Cattle  
 Muscle   
 
Not established   
 
 
- 
 21 days Norbrook 
Laboratories Limited  
Station Works  
Camlough Road  
Newry  Co. Down  
BT35 6JP  
Northern  Ireland    Milk  Zero  
2.4.1.2. Diclofenac  
 Cattle  
 Muscle   
 
Not established   
 
 
- 28 days  Genevet limited  
Milk  7 days  
2.4.1.3. Flunixin meglumine  
 
 
 Cattle  
 
 
 Muscle   
Not established  
  
 
- 14 days  Drugs and Their Usage  
William D.Grimly 1998 , 
pp. 155  
 
The Veterinary Formulary 
6th ed. 
Yolande Bishop 2005 
pp.344  145 
  Milk  2 days  The Veterinary Formulary 
6th ed. Yolande Bishop 
2005 pp.344  
2.4.1.4. Ketoprofen  
 Cattle  
 
 
 
 Muscle  Ketoprofen  
HPLC  Allegrini A, Nuzzo L, 
Zucchelli M, Scaringi 
AT, Felaco S, 
Giangreco D, Pavone 
D, Toniato E, 
Mezzetti A, Martinotti 
S, Comuzio S, Di 
Grigoli M. Fast  (2009)   
HPLC method  for the 
determination of 
ketoprofen in human 
plasma using a 
monolithic column 
and its application to a 
comparative 
bioavailability  study 
in man.  
Arzneimittelforschung
.;59(3):135 -40. 4 days  
 
 
i.v. 1 day  
i.m. 4 days  
  
MARKETING 
AUTHORISATION 
HOLDER , Orion 
Corporation , P.O. BOX 
65 Fin - 02101 Espoo  
 
The Veterinary Formulary 
6th ed. 
YOLANDE BISHOP 2005 
PP.345  
Milk  Zero  
2.4.1.5. Meloxicam  
 
 Cattle  Muscle  Meloxicam  
HPLC  Rigato HM, Mendes 
GD, Borges NC, 
Moreno RA.(2006) 
Meloxicam 
determination in 
human  plasma by 
high-performance 
liquid  chromatography 
coupled with tandem 
mass  spectrometry 
(LC-MS-MS) in 
Brazilian  15 days   
The Veterinary Formulary 
6th ed.Yolande Bishop 
2005 pp.345  Milk  5 days  146 
 bioequivalence 
studies.  Int J Clin 
Pharmacol 
Ther. ;44(10):489 -98 
2.4.1.6. Tolfenamic acid  
 
 Cattle  
 Muscle   
Not established   
- i.v. 3 days  
s.c. 7 days  Vétoquinol UK Limited  
Vetoquinol House  
Great Slade  
Buckingham Industrial 
Park 
Buckingham  
MK18 1PA  
 Milk  1 days  
2.4.2.  Residue definition, Method of detection and withdrawal periods of  Steroidal AI  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of 
detection  
(Technique)   
 
References  
  
 
Withdrawal 
period   
 
References  
 Species  Tissue 
or 
product  
2.4.2.1. Dexamethasone  
 Cattle  Muscle  Dexamethasone.  
HPLC  Kumar V, Mostafa S, 
Kayo MW, Goldberg EP, 
Derendorf H(2006). 
HPLC determination of  
dexamethasone in human 
plasma and its 
application to an in vitro 
release study  
from endovascular stents. 
Pharmazie;61(11):908 -
11. 8 days  Dopharma 
Research B.V.  
Zalmweg 24  
4941 VX  
Raamsdonksveer  
The Netherlands    Milk   3 days  147 
 2.4.2.2. Hydrocortisone  Cattle  Milk   
Not established   
-  
Not 
established   
- 
2.4.2.3. Prednisolone  
 Cattle  
 Muscle   
Not established   
-  
3 days  Pfizer Animal 
Health  
Tetra -Delta Pfizer  
 
 
2.5.  RESIDUE DEFINITION, METHODS OF  DTECTION AND WITHDRAWAL PEROIDS  OF HORMONES  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of detection  
(Technique)   
 
References  
  
 
Withdrawal 
period   
 
References  
 Species  Tissue 
or 
product  
2.5.1. Cloprostenol  
 
 Cattle  Edible 
tissues   
14C-cloprostenol. 
lactone and its tetranor 
acid 
 
Radioactive  liquid 
chromatography  
atmospheric pressure 
chemical ionization 
tandem mass 
spectrometry  
 (LC-APCI -MS-MS)  
 
Annex II of Council 
Regulation (EEC) 
No. 377/90 . 
 2 days  
 
 
 
1 days  VIRBAC S.A.  
1ère avenue – 2065 
m – L.I.D.  
06516 Carros  
FRANCE  
The Veterinary 
Formulary 6th ed.Yolande 
Bishop 2005 pp.329   
 Milk  Zero  148 
 2.5.2. Estradiol -beta 
 
 Cattle  
 
 Muscle   
17alpha -
hydroxytrenbolone 
and 17Beta -
hydroxytrenbolone  
 
GC/MS   
Wu YY, Shi WX, 
Chen SQ.(2009) 
[Determination of 
beta-estradiol, 
bisphenol A,  
diethylstilbestrol and 
salbutamol in human 
urine by GC/MS]. 
Zhejiang Da Xue 
Xue 
Bao Yi Xue 
Ban.;38(3):235 -41 
  Zero  The Veterinary 
Formulary 6th ed.Yolande 
Bishop 2005 pp.323  
2.5.3. Gonadotrophin  
 
  
All food 
producing 
species  Edible 
tissues   
Not established   
- Zero  The Veterinary 
Formulary 6th ed.Yolande 
Bishop 2005 pp.323  
2.5.4. Melengestrol acetate  
 
 Cattle  
 Muscle   
Melengestrol acetate  
liquid chromatograph y 
(LC)   
Weigand JL, Dille 
DS.(1988) 
Determination of 
melengestrol acetate 
in feedstuffs with  
liquid 
chromatographic 
preparatory column 
cleanup and 
quantitative analysis  
J Assoc Off Anal 
Chem.;71(4):707 -9.  2 days  Modern Livestock& 
Poultry Production 7th ed. 
James R.Gillespie 2004, 
pp.142  149 
 2.5.5. Oxytocin  
 
  
All food 
producing 
species  Edible 
tissues   
Not established   
- Zero  Intervet UK Ltd.  
Walton  Walton Manor  
Milton Keynes  MK7 7AJ  
The Veterinary 
Formulary 6th ed.Yolande 
Bishop 2005 pp.331  
2.5.6. Progesterone  
 
 Cattle  
 Muscle   
Not established   
- Zero  
 
 
 
 
6 h  Ceva Animal Health Ltd  
Unit 3, Anglo Office 
Park,  
White Lion Road,  
Amersham,  
Buckinghamshire  
HP7 9FB  
The Veterinary 
Formulary 6th ed.Yolande 
Bishop 2005 pp.327  
Milk  Zero  The Veterinary  
Formulary 6th ed.Yolande 
Bishop 2005 pp.327  
2.5.7. Testosterone  
 
 Cattle  
 Muscle   
Not established   
- Zero  Modern Livestock& 
Poultry Production 7th ed. 
James R.Gillespie 
2004 ,pp.145  
 
 
 
 150 
 2.6.  RESIDUE DEFINITION, METHODS OF DTECTION AND WITHDRAWAL PEROIDS  OF GROWTH  
PROMOTING AGENTS  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of detection  
(Technique)   
 
References  
  
 
Withdrawal 
period   
 
References  
 Species  Tissue 
or 
product  
2.6.1. Arsanilic acid  
 
 
 
 
 
 Chicken  
 
 Muscle   
Arsenic  
Atomic Absorption 
Spectrophotometry  
 
 
    
 W.A.Maher  (1981)  
Determination of 
inorganic and methylated 
arsenic species in marine 
organisms and sediments  
analytica Chimica Acta, 
126 (1981) 157 -165 
Elsevier  5 days  
University of Nebraska 
- Lincoln  
DigitalCommons@Uni
versity of Nebraska - 
Lincoln  . The board of 
reagents of the Univ. of 
Nebraska  
www.ucsusa.org/assets/
documents/.../hog_apps.
pdf Turkey  Muscle  5 days  
2.6.2. Clenbuterol  
hydrochloride  
 
 Cattle  
 
 Muscle   
Clenbuterol  
GC-MS  
 Limin  He Yijuan  Su 
Zhenling  Zeng Yahong  
LiuXianhui  Huang (2007)  
Determination of 
ractopamine and 
clenbuterol in feeds by 
gas chromatography –
mass spectrometry  
Animal  Feed  Science  and 14 days   
Boehringer Ingelheim 
Limited,  
Ellesfield Avenue,  
Bracknell,  Berkshire  
RG12 8YS  
United Kingdom  Milk  Zero  151 
 Technology  
Volume  132, ( 3–4), 
316–323 
 
2.6.3. Ractopamine  
 
 Cattle  
 
 
 Muscle  
Ractopamine  
HPLC  
Used in swine only  Elanco Report # -231 Zero  ELANCO® Division Eli 
Lilly Canada Inc., 150 
Research Lane, Suite 
120, Guelph, Ontario, 
Canada N1G 4T2  
2.6.4. Rosarsone  
 
 
 Chicken  
 Muscle  
Roxarsone  
 
Atomic absorption  
 
spectrophotometry  Frahm LJ, Albrecht ME, 
McDonnell JP.(1975) 
Atomic absorption 
spectrophotometric  
determination of 4 -
hydroxy -3-
nitrobenzenearsonic acid 
(roxarsone) in premixes. 
J  
Assoc Off Anal Chem. 
58(5):945 -8.  
 
5 days   
 
www.ucsusa.org/assets/
documents/.../hog_apps.
pdf  Turkey  Muscle  
2.6.5. Trenbolone  acetate  
 
 Cattle  
 Muscle  Beta-Trenbolone  
 
LC-MS Masakazu  Horie, , 
Hiroyuki  Nakazawa  
(2000)  Determination of 
trenbolone and zeranol in 
bovine muscle and liver 
by liquid 
chromatography –
electrospray mass 
spectrometry  
J.chromatogr.B  Zero  The Nutritio n and 
Management section  of 
the Alberta Feedlot 
Management Guide ,2nd  
Edition published 
September 2000  
Pfizer Animal Health  
2.6.6. Zeranol  
 Cattle  Muscle  Zeranol  
HPLC  Zero  Cooper Veterinary 
Products (Pty) Ltd  
Co. Reg. No. 
2002/021376/07  152 
 Volume 882, Issues 1 –2, 
53–62 
2.6.7. Zilpaterol  
 Cattle  
 Muscle   
Zilpaterol  
 
HPLC   C.S Stachel , W Radeck ,P 
Gowik (2003)  
Zilpaterol —a new focus 
of concern in residue 
analysis Analytica 
Chimi ca Acta 493 (2003) 
63–67 10 days  Analytica Chimica Acta 
493 (2003) 63 –67 
 
 
 
 
 
 
 
 
 
 153 
 2.7.  RESIDUE  DEFINITION,   METHODS   OF DTECTION   AND WITHDRAWAL   PEROIDS   OF  NERVOUS  
SYSTEM  DRUGS  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of 
detection  
(Technique)   
 
References  
  
 
Withdrawal 
period   
 
References  
 Species  Tissue 
or 
product  
2.7.1. Doxapram HCl  
 
 All 
mammalia
n food 
producing 
species   
Edible 
tissues  DoxapramHCl  
 
LC-MS-MS Guanyang  Lin, 
 Jianshe  Ma,Lufeng  
Hu,Xuebao  
Wang ,Jiayin  
Zhu, Xianqin  
Wang (2011) 
Determination of 
Doxapram 
Hydrochloride in 
Rabbit Plasma by LC -
MS-MS and Its 
Application 
Chromatographia  
73, ( 1-2),  183-187 28 days Pfizer Limited  
Ramsgate Road  
Sandwich  
Kent  
CT13 9NJ  154 
 2.7.2. Ketamine  
 
  
All food 
producing 
species  Edible 
tissues  Ketamine  
GC-MS 
  
Ya-Hsueh  Wu Keh-
Liang Lin,  Su-Chin 
Chen,  Yan-Zin 
Chang( 2008 ) 
1. Simultaneous 
quantitative 
determination of 
amphetamines, 
ketamine, opiates and 
metabolites in human 
hair by gas 
chromatography/mass 
spectrometry  
Rapid Communications 
in Mass Spectrometry  
Volume  22, ( 6,)  887–
897, 
  
3 days 
Milk 2  days  
Food Animal Residue 
Avoidance & Depletion 
Program (FARAD) 
http://www.farad.org/eld
u/prohibit.html  
2.7.3. Procaine HCl  
 
  
All food 
producing 
species  Edible 
tissues  Procaine HCl  
 
Spectrophotometric  
method   Lian Dong  Liu Yuan  
Liu Huai  You Wang  
 Yue SunLi Ma Bo 
Tang (2000) Use of  p-
dimethylaminobenzalhy
de as a colored rea gent 
for determination of 
procaine ydrochloride 
by spectrophotometry  3 days Food Animal Residue 
Avoidance & Depletion 
Program (FARAD) 
http://www.farad.org/eld
u/prohibit.html  155 
 Talanta  52, 6 , 991 –999 
2.7.4. Tricaine Methane 
sulfonate  
  
Salmonids   
Muscle   
Not established   
-   70 days  Pharmaq Limited  
Unit 15  Sandleheath 
Industrial Estate  
Fordingbridge  
Hants SP6 1PA  
 
2.7.5. Xylazine  Cattle  Muscle   
Not established   
- 14 days  Chanelle Animal Health 
Ltd, 7 Rodney St.  
Liverpool L1 9HZ  UK. 
 
 
 
 
 
 
 
 
 
 156 
 2.8.  RESIDUE   DEFINITION,   METHODS  OF DTECTION AND WITHDRAWAL PEROIDS  OF 
CARDIOVASCULAR  SYSTEM  DRUGS  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of detection  
(Technique)   
 
References  
  
 
Withdrawal 
period   
 
References  
 Species  Tissue or 
product  
2.8.1. Epinephrine  
 
 All food 
producing 
species   
Edible 
tissues  Epinephrine  
High Performance 
Liquid 
Chromatography 
(HPLC)  Kumar Mishra Amrita 
Mishra and Pronobesh 
Chattopadhyay(2010) A 
reversed -phase high 
performance liquid 
chromatographic 
method for 
determination of 
Epinephrine in 
pharmaceutical 
formulation  
Archives of Applied 
Science Research, 2 
(2):251 -256 Zero   
Dechra Limited  
Dechra House  
Jamage Industrial 
Estate  
Talke Pits  
Stoke -on-Trent  
Staffordshire  
ST7 1XW , UK  
 
 
 
 157 
 2.9.  RESIDUE DEFINITION, METHODS OF DTECTION AND WITHDRAWAL PEROIDS  OF RESPIRATORY  
SYSTEM  DRUGS  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of 
detection  
(Technique)   
 
References  
  
 
Withdrawal 
period   
 
References  
 Species  Tissue or 
product  
2.9.1. Bromhexine  
 
 Cattle   
Edible 
tissues  
  
 
Bromhexine  
 
 
Spectrophotometric  
method   Ana C.B.  
DiasJoão L.M. 
Santos   José L.F.C. 
Lima  Elias A.G. 
Zagatto  (2003 ) 
Multi -pumping 
flow system for 
spectrophotometric 
determination of 
bromhexine  
Analytica Chimica 
Acta   499,( 1 –
2),107 –113 Oral 2 days  
Inject. 28 
days Boehringer Ingelheim Limited  
Ellesfield Avenue  
Bracknell Berkshire  
RG12 8YS, UK 
Poultry  Edible 
tissues  
 Oral zero  MINH DUNG VETERINARY 
- AQUACULTURE 
MEDICINE COMPANY LTD. 
| Web Design : VietProtocol  
Address: 47/4B Khanh Hoi 
Village, Tan Ph uoc Khanh 
Town, Tan Uyen District, Binh 
Duong Province, Viet Nam  
2.9.2. Etamiphylline  
camsilat  
 All food 
producing 
species   
Edible 
tissues   
Not established   
- 7 days  Dechra Limited,  Dechra 
House,  Jamage Industrial 
Estate,  Talke Pits,  Stoke -on-
Trent,  Staffordshire,  ST7 
1XW,  UK. 
 
 158 
 2.10.  RESIDUE DEFINITION, METHODS OF DTECTION AND WITHDRAWAL PEROIDS  OF DIGESTIVE  
SYSTEM  DRUGS  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of detection  
(Technique)   
 
References  
  
 
Withdrawal  
period   
 
References  
 Species  Tissue or 
product  
2.10.1. Atropine sulfate  
 
 All food 
producing 
species   
Edible 
tissues   
Not established  - 14 days  
Milk 3 days  Food Animal 
Residue 
Avoidance & 
Depletion 
Program 
(FARAD) 
http://www.farad.
org/eldu/prohibit.
html 
2.10.2. Poloxalene  
 All food 
producing 
species  Edible 
tissues  Poloxalene  
Spectrophotometric   
method  Nabeel S. Othman and  
Shilan A. Omer(2008)  
Indirect 
Spectrophotometric 
Method for Determination 
of Bromhexine -
Hydrochloride in 
Pharmaceutical  
Preparations Raf. Jour. 
Sci., 19, (2), 16  -  27 , Zero  Phibro Animal 
Health  
Pfizer, Inc.  
 159 
 2.11.  RESIDUE DEFINITION, METHODS OF DTECTION AND WITHDRAWAL PEROIDS  OF URINARY  
SYSTEM  DRUGS  
 
Drug groups  Food commodity   
Residue Definition  
(Marker residue)  
and 
Method of 
detection  
(Technique)   
 
References  
  
 
Withdrawal 
period   
 
References  
 Species  Tissue or 
product  
 
2.11.1 . Hydrochlorothiazide  
 
  
Cattle   
Edible 
tissues   
Hydrochlorothiazide  
Gas 
Chromatography  
(GC)  K. Szyrwińska  
A. Kołodziejczak  
I. RykowskaW. Wasiakand 
J. Lulek(2007)  
Derivatization and gas 
chromatography – 
low-resolution mass 
spectrometry  
of bisphenol a  
Acta Chromatographica,. 
18,49 -58 3 days  
Milk 2  days Vetoquinol 
Co.France