EN   EN 
 
 
 EUROPEAN  
COMMISSION   
Brussels, XXX   
[…](2022) XXX  draft  
ANNEX  
 
ANNEX  
to the  
Commission Regulation (EU) .../...  
amending Regulation (EC) No 1223/2009 of the European Parliament and of the Council 
as regards the use in cosmetic products of certain substances classified as carcinogenic, 
mutagenic or toxic for reproduction  
   
EN 1  EN ANNEX  
 
Annex II  is amended as follow s: 
(1) entry 1024 of Annex II is replaced by the following:  
 
Reference 
number  Substance ide ntification  
 
Chemical name/INN  CAS number  EC n umber  
a b c d 
ʻ1024  2-ethylhexanoic acid and its salts with the 
exception of those specified elsewhere in Annex 
VI to Regulation (EC) No 1272/2008  149-57-5/- 205-743-6/-’ 
 
(2) the following entries are added:  
 
Reference 
number  Substance ide ntification  
 
Chemical name/INN  CAS number  EC n umber  
a b c d 
ʻX  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Ammonium bromide  12124 -97-9 235-183-8 
X [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Dibutyltin bis(2 -ethylhexanoate)  2781 -10-4 220-481-2 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Dibutyltin di(acetate)  1067 -33-0 213-928-8 
X  [OP: 
please 
replace Tellurium dioxide  7446 -07-3 231-193-1  
EN 2  EN with the 
next 
consecutive 
number ] 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Barium diboron tetraoxide  13701 -59-2 237-222-4 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] 2,2-dimethylpropan -1-ol,tribromo derivative; 
3-bromo -2,2-bis(bromomethyl)propan -1-ol 36483 -57-5/ 
1522 -92-5 253-057-0/- 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] 2,4,6 -tri-tert-butylphenol  732-26-3 211-989-5 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] 4,4’-sulphonyldiphenol; bisphenol S  80-09-1 201-250-5 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Benzophenone  119-61-9 204-337-6 
X  [OP: 
please 
replace 
with the 
next 
consecutive Quinoclamine (ISO); 2 -amino -3-chloro -1,4-
naphthoquinone  2797 -51-5 220-529-2  
EN 3  EN number ] 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Perfluoroheptanoic acid; 
tridecafluoroheptanoic acid  375-85-9 206-798-9 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] methyl N-(isopropoxycarbonyl) -L-valyl -
(3RS) -3-(4-chlorophenyl) -β-alaninate; 
valifenalate  283159 -90-0 608-192-3  
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] 6-[C12 -18-alkyl -(branched, unsaturated) -2,5-
dioxopyrrolidin -1-yl]hexanoic acid, sodium 
and tris(2 -hydroxyethyl)ammonium salts   - 701-271-4  
X  [OP: 
please 
replace 
with the 
next 
consecuti ve 
number ] 6-[(C10 -C13) -alkyl -(branched, unsaturated) -
2,5-dioxopyrrolidin -1-yl]hexanoic acid  2156592 -54-8  701-118-1 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] 6-[C12 -18-alkyl -(branched, unsaturated) -2,5-
dioxopyrrolidin -1-yl]hexanoic acid  - 701-162-1 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Theophylline; 1,3 -dimethyl -3,7-dihydro -1H-
purine -2,6-dione  58-55-9 200-385-7 
X  [OP: 1,3,5 -triazine -2,4,6 -triamine; melamine  108-78-1 203-615-4  
EN 4  EN please 
replace 
with the 
next 
consecutive 
number ] 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Fluopicolide (ISO); 2,6 -dichloro -N-[3-chloro -
5-(trifluoromethyl) -2-
pyridylmethyl]benzamide  607-285-6 239110 -15-7 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] N-(2-nitrophenyl)phosphoric triamide  874819 -71-3 477-690-9 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] N-(5-chloro -2-isopropylbenzyl) -N-
cyclopropyl -3-(difluoromethyl) -5-fluoro -1-
methyl -1H-pyrazole -4-carboxamide; 
isoflucypram  1255734 -28-1 811-438-4 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Reaction mass of 3 -(difluoromethyl) -1-methyl -
N-[(1RS,4SR,9RS)-1,2,3,4 -tetrahydro -9-
isopropyl -1,4-methanonaphthalen -5-
yl]pyrazole -4-carboxamide and 3 -
(difluoromethyl) -1-methyl -N-[(1RS,4SR,9SR)-
1,2,3,4 -tetrahydro -9-isopropyl -1,4-
methanonaphthalen -5-yl]pyrazole -4-
carboxamide [>78% syn isomers <15% anti 
isomers relative content]; isopyrazam  881685 -58-1  632-619-2  
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Margosa, ext. [from the kernels of Azadirachta 
indica  extracted with water and further 
processed with organic solvents]  84696 -25-3 283-644-7 
X  [OP: 
please Cumene  98-82-8 202-704-5  
EN 5  EN replace 
with the 
next 
consecutive 
number ] 
X  [OP: 
please 
replace 
with the  
next 
consecutive 
number ] 2-ethyl -2-[[(1-oxoallyl)oxy]methyl] -1,3-
propanediyl diacrylate; 2,2 -
bis(acryloyloxymethyl)butyl acrylate;  
trimethylolpropane triacrylate ; 15625 -89-5 239-701-3 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Pentapotassiu m 2,2’,2’’,2’’’,2’’’’ -(ethane -1,2-
diylnitrilo)pentaacetate  7216 -95-7 404-290-3 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] N-
carboxymethyliminobis(ethylenenitrilo)tetra(a
cetic acid) ; Pentetic Acid  (INCI)  67-43-6 200-652-8 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Pentasodium 
(carboxylatomethyl)iminobis(ethylenenitrilo)te
traacetate ; Pentasodium Pentetate  (INCI)  140-01-2 205-391-3 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Acetamiprid (ISO); (1 E)-N-[(6-chloropyridin -
3-yl)methyl] -N'-cyano -N-
methylethanimidamide; (E) -N1-[(6-chloro -3-
pyridyl)methyl] -N2-cyano -N1-
methylacetamidine  135410 -20-7/ 
160430 -64-8 603-921-1/ 
682-791-8 
X  [OP: 
please 
replace 
with the 
next Pendimethalin (ISO); N -(1-ethylpropyl) -2,6-
dinitro -3,4-xylidene  40487 -42-1 254-938-2  
EN 6  EN consecutive 
number ] 
X  [OP: 
please 
replace 
with the 
next 
consecutive 
number ] Bentazone (ISO); 3 -isopropyl -2,1,3 -
benzothiadiazine -4-one-2,2-dioxide  25057 -89-0 246-585-8’