1 
 
 
 
 
  
ISSUED FOR COMMENT S ONLY  
ooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooo  
 
 
 
 
DRAFT  
BELIZE STANDARD  
SPECIFICATION FOR MARKING  AND LABELLING  OF MEDICAL GAS 
CYLINDERS  
 
 
 
 
 
This is a Draft and should not be regarded or used as a Belize Standard.  
 
 
Last date for comments: 27 May 2022 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Belize Bureau of Standards  
Power Lane  
P. O. Box 430  
City of Belmopan , Cayo District  
Belize , Central  America  
 
DBZS 1: Part 8: 202X  
2 
 
 
 
 
 DRAFT BELIZE STANDARD  
SPECIFICATION FOR MARKING  AND LABELLING  OF MEDICAL GAS 
CYLINDERS  
 
 
Committee Representation  
 
The preparation of this standard for the Standards Advisory Council established under the 
Standards Act 1992 was carried out under the supervision of the Belize Bureau of Standards’  
Medical and Industrial Gases  Technical Committee, which at the time comprised the following 
members:  
 
TECHNICAL COMMITTEE  
CHAIR       REPRESENTING  
Ms. Darlinea Chea      Medical Gases Con sultant  
 
MEMBERS       REPRESENTING  
Mr. Leo Smith       Fabrigas Belize Ltd.  
Mr. Glenford Baptist      Fabrigas Belize Ltd.  
Mr. Lloyd Orellano (Technical Secretary)   Belize Bureau of Standards  
 
 
 
 
 
 
 
 
        
 
 
 
 
 
 
 
 
 
 
 
 
 
  
DBZS 1: Part 8: 202X  
3 
 
 
 
 
 Table of Content s 
 
0 FOREWORD  ................................ ................................ ................................ ......................  4 
1 SCOPE  ................................ ................................ ................................ ................................  4 
2 NORMATIVE REFERENCES  ................................ ................................ ..........................  5 
3 TERMS AND D EFINITIONS  ................................ ................................ ...........................  5 
4 REQUIREMENTS ................................ ................................ ................................ ..............  8 
4.1 General Requirements  ................................ ................................ ................................ . 8 
4.2 Specific Requirements ................................ ................................ ................................ . 9 
5 LABEL DIAGRAMS AND EXAMPLES  ................................ ................................ ....... 13 
Annex A  CGA marking system for compressed gas cylinders  (Normative ) ...........................  18 
Appendix B  CGA labeling guide for compressed medical gases classified as drugs  (Normative)
................................ ................................ ................................ ................................ ..................  25 
Annex C : CGA labeling guide for compressed medical gases  classified as medical devices or 
used with medical devices  (Normative)  ................................ ................................ ...................  32 
Annex D : Pure product classifications  (Normative)  ................................ ................................  37 
Annex E : CGA -recommended hazard and precautionary statements and rules for  their use 
(Normative)  ................................ ................................ ................................ ..............................  41 
Appendix F : Guide for use of 360 degree wrap around product  identification for DOT -4L/TC -
4LM and similar cylinders  (Normative)  ................................ ................................ ..................  43 
Appendix G : Hazard and precautionary statements and codes  (Normative)  ...........................  45 
Annex H : CGA -recommended hazard and precautionary statements and   rules  for their use 
(Normative)  ................................ ................................ ................................ ..............................  47 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
  
DBZS 1: Part 8: 202X  
4 
 
 
 
 
 DRAFT BELIZE STANDARD  
SPECIFICATION FOR MARKING AND LABELLING OF MEDICAL GAS 
CYLINDERS  
 
 
0 FOREWORD  
 
0.1 The medical compressed gas industry has developed precautionary labels and 
markings for use on containers of compressed gases, cryogenic liquids, and 
other hazardous materials for the purpose of identifying the contents, warning 
of principal phys ical, health, and environmental hazards, and providing 
appropriate precautionary information following the Globally Harmonized 
System of Classification and Labelling of Chemicals (GHS).  
 
0.2 This standard was established to meet the specific labeling and mark ing needs 
and methods of preparing label information established by GHS specifically for 
medical compressed gases in Belize.  
 
0.3 Labelling of medical gases in Belize follows the United Nations ( UN) 
regulations established in the GHS.  
 
0.4 In drafting this standar d, considerable assistance was derived from the 
following document(s):  
 
a) CGA C -7-2020  - 11th Edition - Guide to Classification and Labeling of  
Compressed Gases , Compressed Gas Association, USA . 
 
b) Title 49 (Transportation) Parts 100 -180, Code of Federal  Regulations, 
U.S. Government Printing Office.  
 
c) Globally Harmonized System of Classification and Labelling of 
Chemicals (GHS), United Nations Economic Commission  for Europe.  
 
1 SCOPE  
 
1.1 This standard provides minimum requirements for labels and markings on 
compressed gas in cylinders and cryogenic liquid containers cylinders 
containing for medical gases namely for medical air, oxygen, carbon dioxide, 
helium, nitrogen, nitrous oxide and mixtures.  
 
1.2 Labels shall be applied to compressed gas and cryo genic liquid containers to 
identify the container contents and to warn of principal physical and health 
hazards associated with the container and its contents.  
 
1.3 Labels as given herein with regard to cylinder handling and storage information 
may be modified  with respect to format so they can be applied as required to  
DBZS 1: Part 8: 202X  
5 
 
 
 
 
 fixed storage vessels, portable tanks, tube trailers, cargo tanks, or other 
packaging.  
 
2 NORMATIVE REFERENCES  
 
The following referenced documents are indispensable for the application of this 
document. For dated references, only the edition cited applies. For undated references, 
the latest edition of the referenced document (including any amendments) applies.  
 
a) BZS XX – Belize Standard Specification for Medical Gases namely for medical air, 
oxyge n, carbon dioxide, helium, nitrogen, nitrous oxide and mixture s. 
 
3 TERMS AND D EFINITIONS  
 
For the pu rpose of this  stand ard, the  following  terms and definitions shall app ly: 
 
3.1 Acute toxicity estimate (ATE)  means the numerical value that is used to 
evaluate acute toxicity.  
 
NOTE:  For an ingredient, the ATE is derived from the lethal 
concentration (LC50), if available, or a converted acute toxicity 
point estimate that is based on an experimentally obtained ra nge 
or the classification category. For a gas mixture, the ATE is 
calculated for inhalation toxicity based on the ATE values for all 
relevant ingredients and the percentage concentration in the 
product.  
 
3.2 Adequate ventilation  means the condition falling  within any or all of the 
following categories:  
 
a) Ventilation to reduce levels of the air contaminant below that which may 
cause personal injury or illness.  
NOTE:  Values have been established by many sources for specific 
chemicals such as permissible exposure limits, threshold limit 
values, and short -term exposure limits.  
 
b) Ventilation sufficient to prevent accumulation to a concentration of 
contaminant vapor in air at a level in excess of 25% of the level set for the 
lower flammable limit; or 
c) Ventilation sufficient to prevent oxygen -deficient (less than 19.5%) or 
oxygen -enriched (greater than 23.5%) atmospheres.  
3.3 Corrosive liquid or gas  means liquid or gas when in contact with living tissue 
causes full thickness destruction of the human s kin within a specified period of 
time.  
  
DBZS 1: Part 8: 202X  
6 
 
 
 
 
 NOTE:  In this publication, this term shall not refer to action on metal 
surfaces.  
 
3.4 Critical temperature  means temperature above which a pure gas cannot be 
liquefied, regardless of the degree of compression.  
 
3.5 Cryogenic liquid  means refrigerated liquefied gas having a boiling point colder 
than –90 °C ( –130 °F) at 101.3 kPa, abs (14.7 psia).  
 
3.6 Distributor  means a ny person or firm who markets filled medical drug gas 
cylinders and who has not performed any manufacturing steps such as filling, 
repackaging, or relabeling.  
 
3.7 Flammable gas  means gas having a flammable range with air at 20 °C  (68 °F)  
and a standard pressure of 101.3 kPa and is classified in one of the two 
categories:  
 
a) Category 1 Gases, which a t 20 °C (68 °F) and a standard pressure of 101.3 
kPa (14.7 psia) : are ignitable when in a mixture of 13% or less by volume 
in air; or have a flammable range with air of at least 12 percentage points 
regardless of the lower flammable limit; or  
b) Category 2 Ga ses, other than those of Category 1, which, at 20 °C  (68 °F)  
and a standard pressure of 101.3 kPa  (14.7 psia) , have a flammable range 
while mixed in air.  
3.8 Flammable liquid  means a liquid having a flash point of not more than 93 °C 
(199.4 °F) and is clas sified in one of four categories:  
 
a) Category 1 - Flash point < 23 °C (73.4 °F) and initial boiling point ≤ 35°C  
(95 °F) ;  
b) Category 2 - Flash point < 23 °C (73.4 °F) and initial boiling point > 35 °C  
(95 °F) ;  
c) Category 3 - Flash point ≥ 23 °C  (73.4 °F)  and ≤ 60 °C; or  
d) Category 4 - Flash point > 60 °C (140 °F) and ≤ 93 °C (199.4 °F) . 
3.9 Flash point  means minimum temperature at which a substance gives off 
flammable vapors that when in contact with sparks or flame ignites . 
 
3.10 Gas means a normally formless fluid that occupies the space of enclosure and 
can be changed to the liquid or solid state by the effect of increased pressure, 
decreased temperature, or both. A gas diffuses.  
 
3.10.1  Gases under pressure: gases are classified, according to their physical 
state when packaged, in one of four groups.   
DBZS 1: Part 8: 202X  
7 
 
 
 
 
 3.10.2  Compressed gas (non -liquefied compressed gas): gas which when 
packaged under pressure is entirely gaseous at –50 °C ( -58 °F); 
including all gases with a critical temperature less than or equal to –50 
°C (-58 °F).  
 
3.10.3  Liquefied gas (liquefied compressed gas): gas when packaged under 
pressure, is partially liquid at temperatures above –50 °C ( -58 °F). A 
distinction is made between:  
a) High pressure liquefied gas: a gas with a critical temperature 
between –50 °C( -58 °F) and 65 °C (149 °F); and  
b) Low pressure liquefied gas: a gas with a critical temperature above 
65 °C (149 °F).  
3.10.4  Refrigerated liquefied gas: gas when packaged is made partially liquid 
because of its low temperature.  
 
3.11 Health hazard  means chemical which is classified as posing one of the 
following hazardous effects: acute toxicity (any route of exposure) ; skin 
corrosion or irritation; serious eye damage or eye irritation; respiratory or skin 
sensitization; germ cell mutagenicity; carcinogenicity; reproductive toxicity; 
specific target organ toxicity (single or repeated exposure); or aspiration hazard.  
 
NOTE: The criteria for determining whether a chemical is classified as 
a health hazard are detailed in Annex A to §1910.1200 —Health 
Hazard Criteria.  
 
3.12 Irritation  means result of a chemical, either liquid or gas (not a corrosive 
chemical), that causes a r eversible inflammatory effect on living tissue at the 
site of contact (such as eyes, skin, or respiratory tract).  
 
3.13 High pressure gas  means liquefied or compressed gas in a container that has a 
pressure of 3450 kPa (500 psi) or higher at 21.1 °C (70 °F ). 
 
3.14  Label  means a display of written, printed, or graphic matter upon the immediate 
container of any article; and a requirement made by or under authority of this 
chapter that any word, statement, or other information appear on the label shall 
not be  considered to be complied with unless such word, statement, or other 
information also appears on the outside container or wrapper, if any there be, of 
the retail package of such article, or is easily legible through the outside 
container or wrapper.  
 
3.15 LC 50 means concentration of a substance in air, exposure to which for a 
specified length of time is expected to cause the death of 50% of the entire 
defined experimental animal population.  
 
NOTE:  LC 50 is usually measured as ppm (mol/mol).  
  
DBZS 1: Part 8: 202X  
8 
 
 
 
 
 3.16 Liquid means substance or mixture which at 50 °C (122 °F) has a vapor 
pressure of not more than 300 kPa (44 psi), which is not completely gaseous at 
20 °C (68 °F) and at a standard pressure of 101.3 kPa (14.7 psi), and which has 
a melting point or initial melting point of 20 °C (68 °F) or less at a standard 
pressure of 101.3 kPa (14.7 psi).  
 
3.17 Manufacturer  means a ny person or firm who produces, fills, repackages 
(transfills), or relabels medical drug gas cylinders.  
 
3.18 Mixture  means mixture,  or a solut ion composed of two or more substances in 
which they do not react.  
 
3.19 Oxidizing gas  means any gas that can, generally by providing oxygen, cause or 
contribute to the combustion of other material more than air does.  
 
NOTE:  Pure gases or mixtures with an oxidizing potential greater than 
23.5% oxygen in nitrogen by volume as defined in ISO 
10156:2010 or an equivalent testing method are regarded as 
oxidizing for DOT, TC, and the United States Occupational 
Safety and Health Administration  (OSHA ) regulatory pu rposes.  
 
3.20 Respiratory Quotient  (RQ), also known as respiratory ratio, means  the volume 
of carbon  dioxide released over the volume of oxygen absorbed during 
respiration.  
   
4 REQUIREMENTS  
 
4.1 General Requirements  
 
a) All statements on labels sh all be brief, accurate, and expressed in simple, 
easily understood terms.  
b) Precautionary information s hall be used only as appropriate. Excessive 
information should not be used. Unnecessary wording on labels could 
develop a disregard for the labels and markings. I t is desirable to use 
uniform precautionary wording when indicating the same hazards for 
different gases.  
c) Precautionary statements shall be in legible type that is in contrast by 
typography or layout with other printed matter on the labels and markings. 
The label shall be displayed in a conspicuous place on the container so it 
can easily be read by the handler or user.  
d) Any additional information regarding hazards, precautionary information, 
response, and storage and disposal should appear in the appropriate  section  
DBZS 1: Part 8: 202X  
9 
 
 
 
 
 of a product's Safety Data Sheet  (SDS). The information on the label shall 
be consistent with the SDS, and the label shall reference the product's SDS.  
e) Gas mixtures can have properties that are similar to those of the individual 
components. Labels  for mixtures shall be based on the physical and health 
hazards of the finished mixture, based on the physical and health hazards of 
its ingredients in accordance with the criteria given in Globally Harmonized 
System of Classification and Labeling of Chemi cals (GHS ). 
f) All United States Department of Transportation  (DOT -4L/TC -4LM ) liquid 
cylinders shall have additional product identification visible from all 
directions. Refer to Annex F for additional instructions . 
4.2 Specific Requirements  
 
4.2.1  Label cont ent for hazard communication  
 
Information required on labels is as follows:  
 
a) Product Identifier;  
Product identifier shall be the proper shipping name and shall match 
the name used on the SDS. It provides a unique means by which the 
user can identify the gas.  
 
b) Signal Word;  
The signal word shall indicate the relative degree of severity of a 
hazard in the diminishing order of DANGER or WARNING. When 
a product has m ore than one hazard, only the signal word 
corresponding to the class of the greatest immediate hazard shall be 
used. The assignment of signal words is based upon the hazard 
classification.  DANGER is mostly used for the more severe hazard 
categories, while WARNING is mostly used for the less severe.  
 
c) Symbol(s)/Pictogram(s);  
Applicable GHS pictograms shall be affixed to indicate hazards in 
the workplace. The  GHS  pictogram shall be no less than 10 mm 
(0.39 in) on each side inclusive of the red border and oriented as a    
diamond.    
DBZS 1: Part 8: 202X  
10 
 
 
 
 
  
                         Flame                  Flame  over circle                  Exploding  bomb  
 
 
                       Corrosion               Gas cylinder              Skull  and crossbones  
 
 
                Exclamation  mark                   Environment                  Health  hazard  
 
Figure 1: Cryogenic liquid label  
Figure 2: GHS Pictograms   
DBZS 1: Part 8: 202X  
11 
 
 
 
 
  
In addition, the background color on the NON -FLAMMABLE GAS 
label must be green.  
 
d) Hazard Statement(s):  
A hazard statement (such as FLAMMABLE GAS) gives notice of 
the hazards present in connection with the customary or reasonably 
anticipated handling or use of the product and shall follow the signal 
word. If a product has several hazardous properties, a statement of 
each significant hazard shall be included. Examples of hazard 
statements and associated signa l words are shown in Table 1.  
          
    Table 1: Examples of hazard statements and their associated signal words  
Hazard statement  Associated 
signal word  
EXTREMELY FLAMMABLE GAS (H220)  
 
MAY FORM EXPLOSIVE MIXTURES WITH AIR (CGA -
HG04)  
 
TOXIC IF INHALED (H331)  
 
CAUSES SEVERE SKIN BURNS AND EYE DAMAGE 
(H314)  
 
MAY CAUSE OR INTENSIFY FIRE; OXIDIZER (H270)  
 
MAY CAUSE CANCER (H350)  
 DANGER  
 
DBZS 1: Part 8: 202X  
12 
 
 
 
 
 CATCHES FIRE SPONTANEOUSLY IF EXPOSED TO 
AIR (H250)  
CORROSIVE TO THE RESPIRATORY TRACT (CGA -
HG22)  
 
CONTAINS GAS UNDER PRESSURE; MAY EXPLODE 
IF HEATED (H280)  
 
HARMFUL IF INHALED (H332)  
 
MAY CAUSE DAMAGE TO CENTRAL NERVOUS 
SYSTEM (H371)  
 
MAY DISPLACE OXYGEN AND CAUSE RAPID 
SUFFOCATION (OSHA -HG01)  WARNING  
 
e) Precautionary Statements (prevention,  response, storage, and 
disposal);  
 
Precautionary statements are intended to supplement the hazard 
statement(s) by briefly describing measures to be taken to avoid 
injury or damage from stated hazards. Normally, one or more 
precautionary measures accompany each hazard statement.  
 
f) Response (first aid, emergency response, accidental spillage or 
exposure)  
Instructions in case of contact and exposure shall be included where 
the results of contact or exposure are severe and immediate treatment 
is desira ble, and where simple remedial measures can be taken safely 
before medical assistance is available. These instructions shall be 
limited to recognized procedures based on simple methods and 
commonly available materials. Simple remedial measures (such as 
washing or removing clothing) shall be included where they lessen 
injury following contact or exposure. Additional instructions in case 
of fire or leak may be included on the labels or in safety literature 
referenced on the label. Such references on the label  to safety 
literature could include SDSs, supplier’s safety booklets, or 
Compressed Gases Association ( CGA ) publications.  
 
g) Storage (handling and storage)  
Important instructions for handling and storage (such as “Use and 
store only outdoors or in a well -ventilated place” and “Close valve 
after each use and when empty”) should be included on the label. 
Additional instructions for container handling and storage may be 
included on the labels or in safety literature referenced on the label. 
Such references on th e label to safety literature could include SDSs, 
supplier’s safety booklets, or CGA publications.  
  
DBZS 1: Part 8: 202X  
13 
 
 
 
 
 h) Name, telephone number, and address of the manufacturer, importer, 
or other responsible party . 
4.2.2  Label content for transport  
 
See Annex A for information on DOT/TC requirements.  
 
4.2.3  Label content for medical applications  
 
See Annexes B and C for additional United States Food and Drugs 
Administration  (FDA ) requirements.  
 
5 LABEL DIAGRAMS AND EXAMPLES  
 
5.1 Label elements and label element codes for pure gases are provided in Annex 
D and include the required signal word, pictogram(s), and hazard and 
precautionary statements. The label diagrams as illustrated in Figures 5 and 6 
provide examples of how label el ements may be arranged on a shoulder and 
sidewall label for  compressed gas cylinders or cryogenic liquid containers.  
 
5.2 Examples of gas -specific labels prepared per the label diagrams and in 
accordance with the general principles given in this publicatio n and showing the 
minimum requirements are illustrated in Figures below . 
 
5.3 The example labels might not contain all language necessary to comply with 
government regulations. It is the responsibility of the gas supplier to ensure that 
the label contains any additional information necessary to comply with 
applicable government regulations.  
 
5.4 The example labels show minimum warnings based upon sources, technical 
information, and experience at the time this edition was published. They are 
subject to perio dic review and might change as new information becomes 
available.  
 
5.5 CGA has developed additional hazard and precautionary statements to convey 
further information specific to the industrial and medical compressed gas 
industry. These additional CGA hazar d and precautionary statements are 
included on the label examples as applicable and can be found in A nnexe s E 
and G. The rules for the use of CGA hazard and precautionary statements on 
labels also appear in Annex E . 
 
5.6 If a label has a transport pictogra m, and a health pictogram, GHS pictogram  
may be used . 
  
DBZS 1: Part 8: 202X  
14 
 
 
 
 
 
Figure 3: Example of a cylinder shoulder label layout  Table 2: Key for Figures 5 and 6  
Color 
block  Figure area  
 Proper shipping name (PSN). Minimum type size 5 mm (0.1875 in).  
 United  States  Pharmacopeia (USP)/ National Formulary from the 
United States  (NF) designation, if permitted.  
 Components for N.O.S. mixtures. At least two components listed 
within parentheses, percentages may be included.  
 UN number. Minimum type size 6 mm (0.2 in) for cylinders with a 
water capacity of 60 L or less, 12 mm (0.47 in) for cylinders with a 
water capacity greater than 60 L.  
 RQ or INHALATION HAZARD, if required. Minimum type size 2 
mm (0.0625 in).  
 Transportation diamond, square -on-point. Minimum size 30 mm 
(1.25 in).  
 FDA -required signal word, if necessary.  
 FDA -required phrases, if necessary.  
 OSHA -required signal word.  
 OSHA -required hazard statement.  
 OSHA -required precautionary statements, additional language if 
necessary.  
 Name, address, and phone number of responsible party.  
 OSHA -required pictogram, if necessary. Minimum size 10 mm 
(0.39in).  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
This example label is provided for illustrative purposes only. See Annex A for 
specifics regarding the height of the PSN, transportation diamond, UN number, 
and RQ/INHALATION HAZARD warnings.  
 
DBZS 1: Part 8: 202X  
15 
 
 
 
 
  
 
 
 
 
 
 
Figure 5: Example of an Oxygen cylinder shoulder label for transport and use  
 
Figure 4: Example of an Air, Compressed cylinder shoulder label   
DBZS 1: Part 8: 202X  
16 
 
 
 
 
  
This example  label  is provided  for illustrative  purposes  only.  See Appendix  A for 
specifics  regarding  the height  of the PSN,  transportation  diamond,  UN number,  and 
RQ/INHALATION  HAZARD warnings.  
 
 
 
 
 
 
Figure 6: Example of a cylinder sidewall label layout   
DBZS 1: Part 8: 202X  
17 
 
 
 
 
 
Figure 7: Example of a Carbon Dioxide, Refrigerated Liquid cylinder sidewall label   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
This example  label  is provided  for illustrative  purposes  only.  See Appendix  A for 
specifics  regarding  the height  of the PSN,  transportation  diamond,  UN number,  and 
RQ/INHALATION  HAZARD warnings  
 
 
 
 
 
 
 
 
 
 
 
  
DBZS 1: Part 8: 202X  
18 
 
 
 
 
 Annex A  
CGA marking system for compressed gas cylinders  
(Normative)  
 
A.1 Labels and Markings  
 
A.1.1  The basic marking, illustrated in Figure A -1, shall consist of a diamond -shaped 
figure indicating the hazard class  of the contained gas combined with a panel 
containing the proper shipping name of the contained gas and the UN 
identification number. The panel shall be located to the left of the diamond.  
 
A.1.2  The word GAS may be used with the hazard identification words 
FLAMMABLE or NON -FLAMMABLE on the diamond -shape figure. The 
hazard class text may be displayed on one or two lines.  
 
A.1.3  Certain gases with subsidiary hazards require multiple square -on-point 
(diamond) labels. For such gases, the basic marking shall include additional 
diamonds denoting the subsidiary hazard or hazards. Hazard class numbers shall 
appear on both the primary an d subsidiary hazard diamond or diamonds. The 
diamonds shall be adjacent to one another,  but their adjoining points are allowed 
to be overlapped by not more than 10 mm (0.375 in), as illustrated in Figures 
A-2 and A -3. The primary hazard diamond shall be pl aced to the left of the 
subsidiary hazard diamond( s) and  not overlapped. Subsidiary labels shall only 
be overlapped on the left side .  
 
A.1.4  The letters USP or NF are also allowed to be shown in this panel following the 
proper shipping name or product ide ntification number. USP refers to United 
States Pharmacopeia and NF refers to National Formulary, both of which are 
published by the United States Pharmacopeia. Refer to Annexes B  and C  for 
additional information.  
 
A.1.5  For Medical Air, the proper shippin g name is "Air, compressed" and the USP 
monograph name is "Medical Air, USP." The letters USP are not allowed to 
follow the proper shipping name "Air, compressed." "Medical Air, USP" may 
appear in the left panel along with the proper shipping name as shown  in Figure 
A-5, or it may appear elsewhere on the label.  
 
A.2 Precautionary Information  
 
CGA's marking system, illustrated in Figure A -5, provides for additional information 
on cylinders such as the name of the supplier, precautions to be observed in the 
handling, storage, and use of the cylinder and/or its contents, and other information of 
value to the user. CGA's marking system allows information for medical or industrial 
use to be included as required by other regulatory bodies. It allows this additiona l 
information to appear above , beside, or below the basic marking as long as it does not 
interfere with the recognition of the basic marking.  
  
DBZS 1: Part 8: 202X  
19 
 
 
 
 
  
 
A.3 Label Dimensions and Modifications  
 
The diamond figure in the basic marking shall measure at least 30 mm (1 .25 in) on each 
side and the corners shall have an included angle of 90 degrees. The hazard class 
number should be not less than 5 mm (0.1875 in) in height. The hazard class words (for 
example: flammable gas) are allowed to be included in the diamond in le tters not less 
than 3.175 mm (0.125 in) in height.  
 
A.4 Left panel  
 
A.4.1  The panel to the left of the diamond shall be white and shall be imprinted with 
the proper shipping name and the UN identification number of the contained 
gas in black characters. Th e characters of the shipping name shall be no less 
than 5 mm (0.1875 in) in height. The UN identification number shall be:  
 
a) 12 mm (0.47 in) in height for containers greater than 60 L (132 lb) water 
capacity;  
 
b) No less than 6 mm (0.2 in) in height for containers greater than 5 L (11 lb) 
to less than or equal to 60 L (132 lb) water capacity; or  
 
c) Marked in a size appropriate for the package for containers less than or equal 
to 5 L (11 lb) water capacity.  
 
A.4.2  The panel shall measure not less than 25 mm (1 in) from top to bottom but is 
allowed to vary in length to accommodate the proper shipping name.  
 
A.4.3  Where required, the letters RQ and/or the words INHALATION HAZARD 
shall be printed in letters not less than 2 mm (0.0625 in) in height.  
 
A.5 N.O.S. Mixtures  
 
For gas mixtures classified as N.O.S., the technical names of at least two components 
that most predominantly contribute to the hazards of the mixture shall appear in 
parenthesis in association with the proper shipping name.  The percentages of the  
components may be included.  
 
A.6 Additional requirement  
 
A.6.1  The basic marking shall be located (a) when space permits, on the shoulder of 
the cylinder, but not covering the current test date, requalification date, or any 
other required permanent markin gs, or (b) on the side of the cylinder, at a point 
approximately two thirds of the distance from the cylinder bottom to the top of 
the valve or cap.  
  
DBZS 1: Part 8: 202X  
20 
 
 
 
 
 A.6.2  The complete CGA marking system may be of any size or shape suitable for 
application to the cylinder on which it is to be used, subject to the restrictions 
that the basic marking shall occupy a position of prominence and that the 
marking system elements meet minimum size requirements.  
 
A.6.3  The complete CGA marking system may have as a background color any color 
that suits the user with the exception that the panel to the left of the diamond 
shall be white and there shall be a contrast between the background color and 
the color that is required for the diamond in the basic marking. When an 
identical or similar background color is desirable, this contrast may be 
accomplished by providing a border of contrasting color to separate the basic 
marking from the background. A similar border is required where the basic 
marking is to be applied to a non -contrasting surface.  
 
A.6.4  The basic marking system shall be firmly affixed to the container and shall be 
of materials that are durable under conditions incident to transportation, storage, 
and use and shall be maintained in legible condition.  
 
A.6.5 The basic marking and/or CGA's marking system shall remain affixed to the 
cylinder, full or empty, as long as it remains in the same gas service. The basic 
marking provides identification of the hazardous material contained in a filled 
cylinder. The info rmation is of equal value to the handlers of empty cylinders, 
as it provides identification of any residual hazardous material that could be 
present in the cylinder. The removal or replacement of the basic marking shall, 
therefore, be performed only by, or  at the direction of, the supplier responsible 
for filling the cylinder.  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
DBZS 1: Part 8: 202X  
21 
 
 
 
 
 
A.7 Illustrative examples  
These illustrations use the style of hazard labels (square -on-point).  
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
NOTE:  The word GAS may be included in the 30 -mm (1.25 -in) 
diamond of the basic marking. The hazard class text may 
be displayed on one or  two lines.  
 
Figure  A-1: Basic  markings  (not to scale)  White panel containing the 
proper shipping name and 
UN identification number 
of the gas. The panel may  
be either  curved  or 
rectangular.  
 Color  of the diamond,  hazard  
class  number,  and pic torial  
symbol  are to be in 
accordance  with comparable  
GHS labels.  The hazard  class 
number shall not be less than 
5 mm (0.1875  in) in height. 
The pictorial symbol shall be 
proportional  in size to that 
shown  in the referenced  
section.  
 
Hazard  class  words,  in 
letters  not less than 30 mm 
(1.25  in), may be used.  
 When necessary to provide 
distinction between  the color 
of the diamond and any 
background  color, a 2 -mm 
(0.0625 -in) border of 
contrasting  color  shall be 
used.  
  
DBZS 1: Part 8: 202X  
22 
 
 
 
 
 The basic marking in Figures A -2 and A -3 illustrate an example when an 
additional diamond is added to denote  the subsidiary hazard.  The primary 
hazard diamond  overlaps  the subsidiary hazard.  
 
 
 
 
 
 
 
 
 
Figure  A-2: Basic  markings  for multiple  hazard  diamonds  (overlapped)  
 
 
 
 
 
 
 
 
 
 
 
The colors of the individual 
diamonds shall be in accordanc e 
with GHS regulations. The 
primary hazard diamond shall be 
placed to the left of the 
subsidiary hazard diamond(s).   
DBZS 1: Part 8: 202X  
23 
 
 
 
 
 The primary and subsidiary hazard diamonds are  truncated  with the 
primary hazard diamond always on the left.  
 
 
 
 
 
 
 
 
NOTE :  For shipments  within  the United  States  or to Canada  that 
originate  in the United  States,  truncating  of the 
diamonds  is permitted.  
 
Figure  A-3: Basic  markings  for multiple  hazard  diamonds  (truncated)  
 
NOTE —When  required  by FDA,  the official  product  name  including  the 
USP/NF  designation  is allowed  to appear  directly  above,  below,  or beside  
the proper  shipping  name  in the panel  or elsewhere  on the label.  
 
 
 
 
The colors of the individual 
diamonds shall be in accordance 
with GHS. The primary  hazard  
diamond  shall  be placed  to the 
left of the subsidiary  hazard  
diamond(s).   
DBZS 1: Part 8: 202X  
24 
 
 
 
 
  
Figure  A-4: Example of  CGA  marking  system  
(not to scale)  
 
 
 
 
 
 
Figure A -5: Example of CGA marking system for domestic shipment of oxygen (not to 
scale).  
 
 
 
 
 
 
 
 
 
 
 
 
 
When the USP/NF markings are required 
by FDA, they are allowed to be displayed 
in the left  panel  This portion  of the label  may be 
used to display the additional 
information required by  FDA.   
DBZS 1: Part 8: 202X  
25 
 
 
 
 
 Appendix B  
CGA labeling guide for compressed medical gases classified as drugs  
(Normative)  
 
This guide contains what is considered to be the minimum requirements for medical gas labels.  
 
This Annex should be used in conjunction with other applicable labeling and marking 
information contained in this publication. For designated medical gases (oxy gen, nitrogen, 
medical air, nitrous oxide, carbon dioxide, and helium), use Annex A  and the example labels 
shown in this Annex.  
 
For medical drug gas mixtures, use Annexes E and G.  
 
The phrases presented as hazard and precautionary statements (i.e., not th e Warning statement 
that begins with “Administration of …”) are directed to the persons who are handling or 
administering the gas and not the person to whom the gas may ultimately be administered. In 
some cases when the first aid statement "If Inhaled" is indicated by Annex G, it is appropriate 
to modify those words to "If Accidently Inhaled" given that drug gases and gas mixtures are 
purposely intended to be inhaled by the person to whom they are administered.  
 
B.1 General requirements  
 
All medical drug ga s labels shall bear the:  
 
B.1.1  Name and address of the manufacturer or distributor. Where the medical gas 
distributor’s name appears on the label, the distributor’s name shall be qualified 
by one of the following phrases:  
 
a) “Manufactured for (name)”  
b) “Distr ibuted by (name)”  
c) “Manufactured by (name) for (name)”  
d) “Manufactured for (name) by (name)”  
e) “Distributor: (name)” or  
f) “Marketed by (name)”;  
 
NOTE : If cylinders are owned by one company but filled by another 
company, the use of a small ownership or possession sticker in 
addition to the drug product label is allowed (see Figure B -1). 
 
g) Official product name (for single -component gases);  
h) Statement of ing redients (for gas mixtures including %);  
i) Lot number; and  
j) Net contents, in appropriate units of measure as follows:  
 
i. If the medical gas is in a gaseous state in a high-pressure  final use 
container, it shall be expressed in liters or cubic feet qualified by the 
statement "at 70 °F and ## psi"   
DBZS 1: Part 8: 202X  
26 
 
 
 
 
 ii. If the medical gas is in a liquefied compressed gas state in a high-
pressure  final use container it shall be expressed in gaseous liters, or 
by an appropriate net weight statement  
 
iii. If the medical gas is in a liquefied st ate in a portable cryogenic final 
use container it shall be expressed in gaseous liters, liquid liters (if 
identified as a liquid measure), gallons, or by an appropriate net 
weight statement  
 
iv. If the medical gas is in a refrigerated liquid or high-pressure  tube 
transport (i.e., non -final use container), labeling for net quantity of 
contents is not required or  
 
v. If the medical gas is in a large non -portable cryogenic storage 
container or high-pressure  storage bank (i.e., non -final use container 
that supplies p roduct via a pipeline), labeling for net quantity of 
contents is not  required.  
 
B.1.2  Expiration date is not a mandatory requirement for medical gases. If 
manufacturer’s Standard Operating Procedures (SOP) requires that appropriate 
stability test data to support the expiration date, it may appear with other 
information on a separate sticker instead of the main product label or in the 
Purity Certificate.  
 
NOTE : The lot number and/or net contents may appear on a separate 
sticker instead of on the main product label . Figure B -2 provides 
an example of a separate sticker containing supplementary 
information.  
 
B.1.3  The small ownership sticker shall only identify the cylinder owner (name, 
address, and/or phone number) and shall contain the words “property o f” or 
“owned by”. The sticker shall be placed so it cannot be confused with the 
product label. The sticker should not contain language that can be confused with 
language on the product label.  
 
B.1.4  If a separate sticker is used for this information, it sh all be applied in close 
proximity to the main product label.  
 
 
 
Figure  B-1: Example  of a small  ownership  sticker  Property  of COMPANY 
NAME  COMPANY  
ADDRESS  
 
COMPANY  PHONE  NUMBER   
DBZS 1: Part 8: 202X  
27 
 
 
 
 
  
NOTE : Open -topped dewars filled from a liquid nitrogen NF supply do 
not require drug or device product labeling; however,  they 
should be identified  with the word  "Nitrogen."  
 
Figure  B-2: Example  of a separate  sticker  containing  supplementary  information  
 
 
B.2 Specific required statements for certain Designated Medical Gases  
 
The following example labels include required statements used in conjunction with 
other applicable labeling and marking information contained in this publication.  
Statements are appropriate for both compres sed and cryogenic liquid labels for 
Designated Medical Gases  
 
Example of an Oxygen, Compressed USP cylinder label text.  
 
a) OXYGEN, COMPRESSED  
b) USP 
c) UN 1072  
d) WARNING:  
i. For emergency use only when administered by properly trained personnel 
for oxygen deficiency and resuscitation. For all other medical applications. 
By prescription only.  
 
ii. Uninterrupted use of high concentrations of oxygen over a long duration, 
without monitoring its effect on oxygen content of arterial blood, may be 
harmful.  Do not att empt to use on patients who have stopped breathing 
unless used in conjunction with resuscitative equipment.  
e) Produced by Air Liquefaction  
f) Keep out of reach of children; and  
g) This container is to be refilled with oxygen USP only by establishments registered  
as a drug manufacturer or transfiller.  
h) DANGER:  
i. MAY CAUSE OR INTENSIFY FIRE.  
ii. OXIDIZER.  
iii. CONTAINS GAS UNDER PRESSURE.  MAY EXPLODE IF HEATED.  
 
i) Do not handle until all safety precautions have been read and understood.  
j) Keep and store away from clothing and oth er combustible materials.  
k) Keep valves and fittings free from grease and oil.  
l) Use and store only outdoors or in a well -ventilated place.  #######  
LOT  NO. 
####  LITERS   
DBZS 1: Part 8: 202X  
28 
 
 
 
 
 m) In case of fire: stop leak if safe to do so.  
n) Use back flow preventive device in the piping.  
o) Use only with equipment of c ompatible materials of construction and rated for 
cylinder pressure.  
p) Use only equipment cleaned for oxygen service.  
q) Do not open valve until connected to equipment prepared for use.  
r) Open valve slowly.  
s) Close valve after each use and when empty.  
t) Protect from sunlight when ambient temperature exceeds 52°C (125.6 °F)  
u) Read and follow the Safety Data Sheet (SDS) before use.  
v) DO NOT REMOVE THIS LABEL.  
w) COMPANY NAME, ADDRESS AND PHONE NUMBER.  
 
NOTE : Consideration should be given to adding a statement on m edical oxygen 
cylinders that reads "Do not smoke" to advise consumers.  
 
This example label is provided for illustrative purposes only. See Annex A for specifics 
regarding height of proper shipping name, transportation diamond, UN number, and 
RQ/INHALATION HAZARD warnings.  
 
 
Example  of an Oxygen,  Refrigerated  Liquid  USP  cylinder  label text  
 
a) OXYGEN, REFRIGERATED LIQUID  
b) USP 
c) UN 1073    
d) WARNING:  
i. For emergency use only when administered by properly trained personnel 
for oxygen deficiency and resuscitation.  For all other medical applications. 
By prescription only . 
ii. Uninterrupted use of high concentrations of oxygen over a long duration, 
without monitoring its effect on oxygen content of arterial blood, may be 
harmful.  Do not attempt to use on patients who have stopped breathing 
unless used in conjunction with resuscitative equipment.  
e) Produced by Air Liquefaction  
f) Keep  out of reach  of children;  and 
g) This container  is to be refilled  with oxygen  USP only by establishments  registered  
as a drug manufacturer or transfiller.  
h) DANGER:  
i. MAY CAUSE OR INTENSIFY FIRE.  
ii. OXIDIZER.  
iii. CONTAINS REFRIGERATED GAS.  MAY CAUSE  
DBZS 1: Part 8: 202X  
29 
 
 
 
 
 CRIOGENIC BURNS OR INJURY.  
iv. COMBUSTIBLE S IN CONTACT WITH OXIDIZING 
REFRIGERATED LIQUIDS MAY EXPLODE ON IGNITION 
OR IMPACT.  
i) Do not handle until all safety precautions have been read and understood.  
j) Keep and store away from clothing and other combustible materials.  
k) Keep valves and fittings free f rom grease and oil.  
l) Use and store only outdoors or in a well -ventilated place.  
m) Wear cold insulating gloves, face shields and eyes protection.  
n) In case of fire: stop leak if safe to do so.  
o) Use back flow preventive device in the piping.  
p) Use only with equipment of compatible materials of construction and 
rated for cylinder pressure.  
q) Use only equipment cleaned for oxygen service.  
r) DO NOT change or force fit connections.  
s) Avoid spills.  Do not walk on or roll equipment over spills.  
t) Do not open valve until c onnected to equipment prepared for use.  
u) Open valve slowly.  
v) Close valve after each use and when empty.  
w) Always keep container in upright position.  
x) Read and follow the Safety Data Sheet (SDS) before use.  
y) FIRST AID  
i. IF ON SKIN: Thaw frosted parts with lukewarm water.  Do not 
rub affected area. Get immediate medical advice/attention.  
z) DO NOT REMOVE THIS LABEL.  
aa) COMPANY NAME, ADDRESS AND PHONE NUMBER.  
 
NOTE :  Consideration should be given to adding a statement on 
medical oxygen cylinders that reads "Do not smoke" to  advise  
consumers.  
 
B.3 Required  statements  for certain  combinations  of Designated  Medical Gases  
other than  Medical  Air 
 
B.3.1  The following -required  statements  shall  be used in conjunction  with other  
applicable  labeling  and marking  information  contained in this  publication, 
specifically Annexes A, E and G.  
  
DBZS 1: Part 8: 202X  
30 
 
 
 
 
 a) Oxygen/Nitrogen  Medical  Mixtures  
 
 
1 The USP or NF designation may be placed before or after the 
component or percentage entry. As an alternate method  of stating  that the 
mixture  was prepared  using  USP or NF gases  when  applicable,  the USP 
or NF designation  after each component may be eliminated, and the 
statement “Gases used to prepare this mixture meet USP or NF 
specifications  where  applicable”  or equivalent  wording  may be added  to 
the label.  Component  names  may appear in any order.  
 
NOTE : If this mixture  is to be used as a respiratory  challenge  mix, 
the label  may indicate  “FOR  USE  WITH  
RESPIRATORY  CHALLENGE  DIAGNOSTIC  
EQUIPMENT  IN ACCORDANCE  WITH  
MANUFACTURERS  INSTRUCTIONS.”  
 
b) Oxygen/Helium  Medical  Mixtures  
 
1 The statement “Gases used to prepare this mixture meet USP 
or NF specifications  where  applicable”  or equivalent  wording  
WARNING :  Administration of this gas mixture may be hazardous or contraindicated. For use 
only by or  under the supervision of a licensed pract itioner who is experienced in 
the use and administration of gas mixtures, and is familiar with the indications, 
effects, dosages, methods,  and frequency and duration of administration, and 
with the hazards, contraindications and  side effects, and the precautions to be 
taken.  
 % Oxygen,  USP 1 
 % Nitrogen,  NF 1 
Rx only 
WARNING :  Administration of this gas mixture may be hazardous or contraindicated. 
For use only by or  under the supervision of a licensed practitioner who is 
experienced in the use and administration of gas mixtures, and is familiar 
with the indications, effects, dos ages, methods,  and frequency and duration 
of administration, and with the hazards, contraindications and  side effects, 
and the precautions to be taken.  
 % Oxygen,  USP 1 
 % Helium,  USP 1 
 
   Rx Only   
DBZS 1: Part 8: 202X  
31 
 
 
 
 
 may be added  to the label.  Component  names  may appear  in any 
order.  
 
c) Oxygen/Carbon  Dioxide  Mixtures  
 
 
 
 
 
 
 
 
 
 
 
 
 
The statement “Gases used to prepare this mixture meet USP or NF 
specifications  where  applicable”  or equivalent  wording  may be added  to the 
label.  Component  names  may appear  in any order.  
 
d) Oxygen/Carbon  Dioxide/Nitrogen  Medical  Mixture  
 
 
1 “Gases used to prepare this mixture meet USP or NF specifications  
where  applicable”  or equivalent  wording  may be added  to the label.  
Component  names  may appear  in any order.  
 
NOTE —If this mixture  is to be used as a respiratory  challenge  mix, the 
label  may indicate  “FOR  USE  WITH  RESPIRATORY  CHALLENGE  
DIAGNOSTIC  EQUIPMENT  IN ACCORDANCE  WITH  
MANUFACTURERS  INSTRUCTIONS”.  
WARNING :  Administration of this ga s mixture may be hazardous or contraindicated. 
For use only by or under the supervision of a licensed practitioner who 
is experienced in the use and administration of gas mixtures, and is 
familiar with the indications, effects, dosages, methods, and freque ncy 
and duration of administration, and with the hazards, contraindications 
and side effects, and the precautions to be taken.  
 % Oxygen,  USP 1 
 % Carbon Dioxide,  USP 1 
 
    
 Rx only 
WARNING :     Administration of this gas mixture may be hazardous or contraindicated. For 
use only by or under  the supervision of a licensed practitioner who is 
experienced in the use and administration of  gas mixtures,  and is familiar  with 
the indications,  effects,  dosages,  methods,  and frequency  and duration  of 
administration,  and with the hazards,  contraindications  and side effects,  and the 
pre- cautions  to be taken.  
  % Oxygen,  USP 1 
  % Carbon  Dioxide,  USP 1 
  % Nitrogen,  NF 1 
Rx only  
DBZS 1: Part 8: 202X  
32 
 
 
 
 
 Annex C  
CGA labeling guide for compressed medical gases classified as medical devices or used 
with medical devices  
(Normative)  
 
This Annex was revised to be consistent with curr ent industry practices as they apply to the 
labeling of certain compressed gases classified as medical devices or used with medical 
devices.  
 
This guide should be used in conjunction with other applicable labeling and marking 
information contained in this publication, specifically Annexes A and D.  
 
C.1 General requirements  
 
All compressed gas medical device labels shall bear the following information:  
 
a) Name and address of manufacturer or distributor. Where the medical gas is not 
manufactured by the person or firm appearing on the label, as is the case with a 
distributor, the name identified on the label shall be qualified by the phrase:  
 
i. “Manufactured for (name)”  
ii. “Distributed by (name)” or  
iii. Any other wording that expresses the connection between the p erson or 
firm named on the label and the medical device gas;  
 
b) Proprietary name and established name (common or usual name), if any;  
 
c) Statement on the application for use;  
 
d) Lot number;  
 
e) Statement of ingredients (including % mol/mol);  
 
f) Adequate directions for use (cylinder handling and storage); and  
 
g) Net contents, in units of measure as follows:  
 
i. If the medical gas is in a gaseous state in a high pressure final use 
container, it shall be expressed in liters or cubic feet qualified by the 
statement “at 70 °F and ##2000 psi”  
 
ii. If the medical gas is in a liquefied compressed gas state in a high 
pressure final use container it shall be expressed in gaseous liters or by 
an appropriate net weight statement  
 
  
DBZS 1: Part 8: 202X  
33 
 
 
 
 
 iii. If the medical gas is in a liquefied s tate in a portable cryogenic final use 
container shall be expressed in gaseous liters, liquid liters (if identified 
as a liquid measure), gallons, or by an appropriate net weight statement 
or 
iv. If the medical gas is in a refrigerated liquid or high pressure tube 
transport (i.e., non -final use container), labeling for net quantity of 
contents is not required.  
 
h) The lot number and/or net contents may appear on the main product label or on a 
separate sticker instead of on the main product label. If a separate sti cker is used for 
this information, it shall be applied in close proximity to the required main product 
label.  
 
i) Open -topped dewars filled from a liquid nitrogen NF supply do not require drug or 
device product labeling but should be identified with the word "Nitrogen."  
 
C.2 Minimum required statements  
 
The following required statements shall be used in conjunction with other applicable 
labeling and marking information contained in this publication, specifically Appendix 
A and applicable hazard and precautiona ry statements (identified by code designations), 
signal words, and GHS or DOT pictograms provided in Annex D.  
 
C.2.1 Lung Diffusion Mixtures  
 
1 As an alternate method the statement “All concentrations are expressed as % 
mol/mol” or equivalent wording may be used instead of using % mol/mol after 
each component. If the mixture does not contain carbon monoxide, the "% 
mol/mol carbon monoxide" statement sha ll not appear.  
 
WARNING :  Administration of lung diffusion mixtures may be hazardous or contraindicated. For 
use only by or  under  the supervision  of a licensed  practitioner  who is experienced  in the 
use and administration  of lung diffusion mixtures and is familiar with the indications, 
effects, dosages, methods, and  frequency and duration of administration, and with the 
hazards , contraindications and side effects,  and the precautions  to be taken.  
 
FIRST  AID:   IF ACCIDENTLY INHALED: Remove person to fresh air and keep comfortable for 
breathing. Get  medical  advice/attention.  
   % mol/mol  1 carbon  monoxide  
   % mol/mol  (name  of gas) USP or NF when  applicable 2 
   % mol/mol  (name  of gas) 2 
   % mol/mol  (name  of gas) 2 
   % mol/mol  (name  of gas) 
FOR USE WITH LUNG DIFFUSION DIAGNOSTIC EQUIPMENT IN ACCORDANCE 
WITH MANUFACTURER’S  INSTRUCTIONS.  
NOT  FOR DRUG  USE.   
DBZS 1: Part 8: 202X  
34 
 
 
 
 
 2 As an alternate method of stating that the mixture was prepared using USP or 
NF gases when applicable, the USP or NF designation after each component 
may be eliminated, and the statement “Gases used to prepare this mixture meet 
USP or NF specifications where applicable” or equivalent wording may be 
added to the label.  
 
C.2.2  Blood  Gas Mixtures  
 
1 As an alternate method the statement “All concentrations are expressed 
as % mol/mol” or equivalent wording may be used instead of using % mol/mol 
after each component.  
 
C.2.3  Calibration  Gas Mixtures  
 
a) Medical gas calibration gas mixtures can fall into three categories based on 
the number and concentration of  their components:  
i. nonflammable,  nonoxidizing  where  the oxygen  concentration  is 
less than or equal  to 23.5%,  including  mix tures  that do not contain 
oxygen;  
ii. nonflammable,  oxidizing  where  the oxygen  concentration  is greater  
than 23.5%;  or 
iii. flammable.  
 
b) Because calibration gas mixtures can contain many different components at 
various concentrations, t he label for calibration gas mixtures shall include, 
in addition to the information shown below, hazard and precautionary 
statements and appropriate GHS or  DOT pictograms and the statements in 
Annexes D, E and G.  
 
    % mol/mol  1 (name  of gas)  
   % mol/mol  (name  of gas) 
   % mol/mol  (name  of gas) 
FOR CALIBRATION OF BLOOD GAS ANALYZERS IN 
ACCORDANCE WITH  MANUFACTURER’S  INSTRUCTIONS.  
 
NOT FOR DRUG USE.   
 
NOT FOR  INHALATION.   
DBZS 1: Part 8: 202X  
35 
 
 
 
 
  
 
 
1 As an alternate method the statement “All concentrations are 
expressed as % mol/mol” or equivalent wording may be  used instead  of 
using  % mol/mol  after each component.  
 
C.3.4  Laser Gases and Laser Gas Mixtures (containing components of noble 
gases, nitrogen, and/or carbon dioxide)  
 
 
1     As an alternate  method  the statement  “All concentrations  are expressed  as 
% mol/mol”  or equivalent  wording  may be used instead  of using  % mol/mol  
after each component.  
 
 
C.3.5  Artificial  Atmosphere  Gas Mixtures  (both  aerobic  and anaerobic)  
 
a) Artificial atmosphere gas mixtures can fall into three categories based upon 
the number and concentration of  their components:  
i. nonflammable,  nonoxidizing  where  the oxygen  concentration  is less 
than or equal  to 23.5%,  including  mixtures  that do not contain 
oxygen;  
ii. nonflammable,  oxidizing  where  the oxygen  concentration  is greater  
than 23.5%;  or    % mol/mol  1 (name  of gas) 
   % mol/mol  (name  of gas) 
   % mol/mol  (name  of gas) 
 
FOR CALIBRATION OF MEDICAL ANALYZERS IN  
ACCORDANCE WITH   MANUFACTURER’S INSTRUCTIONS.  
 
NOT FOR DRUG USE.   
 
NOT  FOR  INHALATION.  
   % mol/mol  1 (name  of gas) 
   % mol/mol  (name  of gas) 
   % mol/mol  (name  of gas) 
 
FOR USE WITH MEDICAL LASER EQUIPMENT. USE IN 
ACCORDANCE WITH  EQUIPMENT  MANUFACTURER'S 
INSTRUCTIONS.  
 
NOT FOR DRUG USE.   
 
NOT  FOR  INHALATION.  
 
FOR  USE  ONLY  BY OR UNDER  THE  SUPERVISION  OF A 
LICENSED  PRACTITIONER  WHO  IS EXPERIENCED  IN THE  USE  
OF LASER  EQUIPMENT.   
DBZS 1: Part 8: 202X  
36 
 
 
 
 
 iii. flammable.  
 
b) Because artificial atmosphere gas mixtures can contain many different 
components at various concentrations,  the label for artificial atmosphere gas 
mixtures shall include, in addition to the information shown below, hazard  
and precautionary statements and appropriate GHS  or DOT  pictograms and 
the statements in Anne xes D,  E and  G. 
 
 
1 As an alternate method the statement “All concentrations are expressed as % 
mol/mol” or equivalent wording may be  used instead  of using  % mol/mol  after 
each component.  
 
2 While commonly used for this application, mixtures could have other 
applications and therefore this statement may be  removed  as applicable.  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    % mol/mol  1 (name  of gas) 
   % mol/mol  (name  of gas) 
   % mol/mol  (name  of gas) 
 
BIOLOGICAL  ATMOSPHERE  MIXTURE  FOR  CULTURE  
GROWTH.  2 
 
FOR LABORATORY USE ONLY.  
 
 NOT  FOR DRUG USE.  
 
NOT  FOR  INHALATION.   
DBZS 1: Part 8: 202X  
37 
 
 
 
 
 Annex D  
Pure product classifications  
(Normative)  
 
This Annex includes the information necessary to create pure material GHS labels, which 
includes GHS classifications with corresponding hazard and precautionary statements, hazard 
categories, signal word, and GHS pictogram(s) or/ DOT for the pure gases lis ted in this 
publication.  
 
For ease of reference, the CAS number, if available, is provided. This information is not 
required for a GHS -compliant label but can be useful for product identification.  This Annex 
does not provide the proper shipping name (PSN)  or other information required to develop 
transportation labels.  
 
See Annexes E and G for wording for the hazard and precautionary statements used in this 
guideline.  
 
 
Carbon  Dioxide,  Refrigerated  Liquid   
Carbon  Dioxide   
Air, Compressed   
Gas name 
124-38-9 124-38-9 132259 -10-0 CAS number  
Gases  under  pressure  
Simple  asphyx iant Gases  under  pressure  
Simple  asphyxi ant Gases  under  pressure  Hazard  class 
Refrigerated  Liquefied  gas Liquefied  gas Compressed  gas Hazard  category  
Warning  Warning  Warning  Signal  word 
Gas cylinder  Gas cylinder  Gas cylinder  GHS  pictogram(s)  
2.2 Nonfla mmable  Gas 2.2 Nonflammable  Gas 2.2 Nonflammable  Gas Transportation  label 
H281  H280  H280  Hazard  statements  
OSHA -H01 OSHA -H01  OSHA -required  hazard  
statement  
CGA - HG03  CGA - HG01  
CGA - HG03  CGA - HG24  CGA -required  hazard  
statements  
P202   
P271+P403   
P282 P202 P261 P262 
P271+P403  P280 P202 Prec.  statements:  prevention  
P304,  P340,   
P313 , P302,   
P336, P315 P304,  P340,   
P313 , P302,   
P336, P315   Prec.  statements:  response  
   Prec.  statements:  storage  
   Prec.  statements:  disposal  
OSHA -PG01  OSHA -PG01  OSHA -PG01  OSHA -required  
precautionary  statement  
CGA -PG05  
 CGA -PG06 
CGA -PG11   
CGA -PG12   CGA -PG02  
 CGA -PG05   
CGA -PG06 
CGA -PG11  CGA -PG02   
CGA -PG05  
 CGA -PG06   
CGA -PG10  CGA -required  precautionary  
statements   
DBZS 1: Part 8: 202X  
38 
 
 
 
 
 CGA -PG20   
CGA -PG23   
CGA -PG24 
CGA -PG27   CGA -PG12   
CGA -PG27  CGA -PG12   
CGA -PG27 
 
 
Nitrogen   
Nitrogen,  Refrigerated  
Liquid   
Helium,  Refrigerated  Liquid   
Helium   
Gas name 
 
7727 -37-9  
7727 -37-9  
7440 -59-7  
7440 -59-7  
CAS number  
Gases  under  pressure  
 
Simple  asphyxiant  Gases  under  pressure  
 
Simple  asphyxiant  Gases  under  pressure  
 
Simple  asphyxiant  Gases  under  
pressure  
 
Simple  asphyxiant  Hazard  class 
Compressed  gas Refrigerated  Liquefied  gas Refrigerated  Liquefied  gas Compressed  gas Hazard  category  
Warning  Warning  Warning  Warning  Signal  word 
Gas cylinder  Gas cylinder  Gas cylinder  Gas cylinder  GHS  pictogram(s)  
2.2 Nonfla mmable  Gas 2.2 Nonflammable  Gas 2.2 Nonflammable  Gas 2.2 Nonflammable  
Gas Transportation  label 
H280  H281  H281  H280  Hazard  statements  
OSHA -H01 OSHA -H01 OSHA -H01 OSHA -H01 OSHA -required  
hazard  statement  
    CGA -required  
hazard  statements  
P202   
P271+P403  P202   
P271+P403   
P282  P202   
P271+P403   
P282 P202   
P271+P403  Prec.  statements:  
prevention  
P304,  P340,  P313  P304,  P340,  P313 
P302,  P336,  P315  P304,  P340,  P313 
P302,  P336,  P315 P304,  P340,  P313 Prec.  statements:  
response  
    Prec.  statements:  
storage  
    Prec.  statements:  
disposal  
OSHA -PG01  OSHA -PG01  OSHA -PG01  OSHA -PG01  OSHA -required  
precautionary  
statement  
CGA -PG02  
CGA -PG05  
CGA -PG06  
CGA -PG10  
CGA -PG12 
CGA -PG27  CGA -PG05  
 CGA -PG06 
CGA -PG12  
CGA -PG23   
CGA -PG24   
CGA -PG27  CGA -PG05   
CGA -PG06 
CGA -PG12   
CGA -PG20   
CGA -PG23   
CGA -PG24   
CGA -PG26 CGA -PG02   
CGA -PG05   
CGA -PG06  
 CGA -PG10   
CGA -PG12 
CGA -PG27  CGA -required  
precautionary  
statements   
DBZS 1: Part 8: 202X  
39 
 
 
 
 
  
 
Oxygen,  Refrigerated  Liquid   
Oxygen   
Nitrous  Oxide,  
Refrigerated  Liquid   
Nitrous  Oxide   
Gas name 
7782 -44-7 7782 -44-7 10024 -97-2 10024 -97-2 CAS number  
Gases  under  pressure  
 
Oxidizing  gas Gases  under  pressure  
 
Oxidizing  gas Gases  under  pressure  
 
Simple  asphyx i ant 
Oxidizing  gas STOT  SE 
dizziness/  drowsi ness Gases  under  pressure  
 
Simple  asphyxi ant 
 
Oxidizing  gas 
 
STOT  SE dizziness/  
drowsiness  Hazard  class 
Refrigerated  Liquefied  gas 
 
Category  1 Compressed  gas 
 
Category  1 Refrigerated  Liquefied  gas 
 
Category  1 
 
Category  3 Liquefied  gas 
 
Category  1 
 
Category  3 Hazard  category  
Danger  Danger  Danger  Danger  Signal  word 
Gas cylinder  Flame  over circle Gas cylinder  Flame  over 
circle Gas cylinder  Flame  over 
circle 
 
Exclamation  mark Gas cylinder  
Flame  over circle  
 
Exclamation  mark GHS  pictogram(s)  
2.2 Nonfla mmable  Gas 
5.1 Oxidizer  2.2 Nonflammable  Gas 
5.1 Oxidizer  2.2 Nonflammable  Gas 
5.1 Oxidizer  2.2 Nonflammable  Gas 
5.1 Oxidizer  Transportation  
label 
H270  H281  H270  H280  H270  H281  H336 H270  H280  H336 Hazard  statements  
  OSHA -H01 OSHA -H01 OSHA -required  
hazard  statement  
CGA - HG13   CGA - HG13  CGA - HG01  CGA -required  
hazard  statements  
P202  
P220  
P244 
P271+P403  
 P282  P202  
P220  
P244 
P271+P403  P202  
P220  
P244  
P261 
P271+P403  
 P282 P202  
P220  
P244 
 P261 
 P262 
P271+P403   
P280 Prec.  statements:  
prevention  
P370,  P376 
P302,  P336,  P315  P370,  P376 P370,  P376 
P304,  P340,  P312 
P302,  P336,  P315 P370,  P376 
P304,  P340,  P312 
P302,  P336,  P315 Prec.  statements:  
response  
  P405 P405 Prec.  statements:  
storage  
  P501 P501 Prec.  statements:  
disposal  CGA -PG27   
DBZS 1: Part 8: 202X  
40 
 
 
 
 
 OSHA -PG01  OSHA -PG01  OSHA -PG01  OSHA -PG01  OSHA -required  
precautionary  
statement  
CGA -PG05   
CGA -PG06 
CGA -PG12   
CGA -PG20   
CGA -PG21   
CGA -PG22  
 CGA -PG23   
CGA -PG24   
CGA -PG27 
CGA -PG28  CGA -PG02  
 CGA -PG05   
CGA -PG06  
 CGA -PG10   
CGA -PG12   
CGA -PG20   
CGA -PG21   
CGA -PG22 
CGA -PG27  CGA -PG05   
CGA -PG06 
CGA -PG12  
CGA -PG21   
CGA -PG22   
CGA -PG23 
CGA -PG27   
CGA -PG28 CGA -PG02   
CGA -PG05   
CGA -PG06   
CGA -PG10 
CGA -PG20  
 CGA -PG21   
CGA -PG22 
CGA -PG27  CGA -required  
precautionary  
statements  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
DBZS 1: Part 8: 202X  
41 
 
 
 
 
 Annex E  
CGA -recommended hazard and precautionary statements and rules for  their  use 
(Normative)  
 
CGA  developed  hazard  and precautionary  statements,  as shown  in Tables  E-1, to convey  
additional  information  or to further  clarify the hazards and  the rules for  their use on labels  and 
SDSs  
 
Table E-1 Precautionary  Statement  Codes (PSCs) , text, and rules  for use 
 
PSCs  STATEMENT  USED ON  
OSHA -PG01  DO NOT  REMOVE  THIS  PRODUCT  LABEL  (or equivalent  
wording).  Label  
Rule  for use: This OSHA  precautionary  statement  is required  on all products.  
 
CGA -PG02  Protect  from  sunlight  when  ambient  temperature  exceeds  52 °C 
(125 °F). Label  and 
SDS 
Rule for use: This CGA precautionary statement is required on all gases except for those classified as 
refrigerated liquefied  gases.  
 
CGA -PG05  Use a back  flow preventive  device  in the piping.  Label  and 
SDS 
Rule  for use: This CGA  precautionary  statement  is required  on all products.  
 
CGA -PG06  Close  valve  after  each  use and when  empty.  Label  and 
SDS 
Rule  for use: This CGA  precautionary  statement  is required  on all products.  
 
CGA -PG10  Use only with  equipment  rated  for cylinder  pressure.  Label  and 
SDS 
Rule  for use: This CGA  precautionary  statement  is required  on all products  with the Gas cylinder  pictogram.  
This statement may be combined with CGA -PG20 into one that reads: "Use only with equipment of 
compatible materials of  construction  and rated  for cylinder  pressure.”  
 
CGA -PG11  Never  put cylinders  into unventilated  areas  of passenger  vehicles.  Label  and 
SDS 
Rule for use: This CGA precautionary statement is required on labels for carbon dioxide; carbon dioxide, 
refrigerated liquid;  liquefied petroleum gas; acetylene; and propane. This CGA statement is used on SDSs 
for all flammable, pyrophoric, toxic,  and refrigerated  liquefied  gases. 
 
CGA -PG12  Do not open  valve  until  connected  to equipment  prepared  for use. Label  and 
SDS 
Rule  for use: This CGA  precautionary  statement  is required  on all products.  
 
CGA -PG20  Use only equipment  of compatible  materials  of construction.  Label  and 
SDS  
DBZS 1: Part 8: 202X  
42 
 
 
 
 
 Rule for use: This CGA precautionary statement is required for DOT -classified corrosives (hazard class 8) 
and gases that  have compatibility issues with materials used in gas handling systems. Known exceptions to 
its use are nonrefrigerated nitro - gen and noble  gases.  
This statement may be combined with CGA -PG10 into one that reads: "Use only with equipment of 
compatible materials of  construction  and rated  for cylinder  pressure.”  
This statement may be combined with CGA -PG22 and CGA -PG32 into one that reads: "Use only with 
equipment constructed  of compatible  materials,  cleaned  for oxygen  service  and passivated  before  use.”  
 
CGA -PG21  Open  valve  slowly.  Label  and 
SDS 
Rule  for use: This CGA  precautionary  statement  is required  on oxidizing  gases  Category  1. 
 
CGA -PG22  Use only with  equipment  cleaned  for oxygen  service.  Label  and 
SDS 
Rule  for use: This CGA  precautionary  statement  is required  on oxidizing  gases  Category  1. 
This statement may be combined with CGA -PG20 and CGA -PG32 into one that reads: "Use only with 
equipment constructed  of compatible  materials,  cleaned  for oxygen  service  and passivated  before  use.”  
 
CGA -PG23  Always  keep  container  in upright  position.  Label  and 
SDS 
Rule  for use: This CGA  precautionary  statement  is required  on refrigerated  liquefied  gases.  
 
CGA -PG24  DO NOT  change  or force  fit connections.  Label  and 
SDS 
Rule  for use: This CGA  precautionary  statement  is required  on refrigerated  liquefied  gases.  
 
CGA -PG26  Use insulated  hoses  and piping  to avoid  condensation  of oxygen -rich 
liquid  air. Label  and 
SDS 
Rule for use: This CGA precautionary statement is required on helium, refrigerated liquid; hydrogen, 
refrigerated liquid; and  neon,  refrigerated liquid.  
 
CGA -PG27  Read  and follow  the Safety  Data  Sheet  (SDS)  before  use. Label  
Rule  for use: This CGA  precautionary  statement  is required  on all products.  
 
CGA -PG28  Avoid  spills.  Do not walk  on or roll equipment  over  spills.  Label  and 
SDS 
Rule  for use: This CGA  precautionary  statement  is required  on refrigerated  liquefied  oxygen  and refrigerated  
nitrous  oxide.  
 
 
 
 
 
 
 
 
 
 
  
DBZS 1: Part 8: 202X  
43 
 
 
 
 
 Appendix F  
Guide for use of 360 degree wrap around product  identification for DOT -4L/TC -4LM 
and similar cylinders  
(Normative)  
 
This Appendix contains the requirement for 360° wrap around product identification for DOT -
4L/TC -4LM  and similar  cylinders  designed  for cryogenic  liquids.  This identification  is in 
addition  to the product  label  containing  hazard warn ings and precautionary information, and 
transportation symbols. It is also referred to in the compressed  gas industry as a  decal and in 
the medical  gas industry as a label.  
 
Appendix  F does  not apply  to: 
a) Large  cryogenic  vessels  permanently  mounted  in vehicles;  
b) Small  liquid  oxygen  cryogenic  units  used by patients  for medical  purposes;  or 
c) Open  topped nitrogen  dewars.  
 
F.1 General  recommendations  
 
F.1.1  Each container designed for cryogenic liquids, except those described 
previously as non -applicable, sho uld be  marked  with a 360 degree  wrap  around  
product  identification  to identify  its contents.  The identification  should  be 
marked  continuously  with the liquid  product  identification.   
 
F.1.2  The identification  should  be sized  (minimum  51 mm [2 in] high letters) and 
spaced so that it is visible from all sides when not obstructed. Placement should 
be horizontal and just below the upper circumferential weld adhering to the 
cylinder sidewall. See Figure F -1 for an  illustration of the decal (oxygen is used 
as an example).  
 
Figure  F-1: Example  of industrial  cryogenic  identification  
 
DBZS 1: Part 8: 202X  
44 
 
 
 
 
 F.1.3  Portable cryogenic medical gas containers utilizing 360° wrap around 
decals as labels  with the text shown in  Table  F-1 as appropriate are  
compliant with applicable regulations.  
F.1.4  Table  F-1 lists the color  options  for each medical  gas. Either  color  option  
may be selected  with 360°  wrap  around label wording.  
 
Table  F-1: Color  coding  for portable  cryogenic  medical  gas containers  
 
Medical  gas Color  (select  one) 360 degrees  wrap around label wording  
(select  one) 
Carbon  dioxide  Gray lettering on white background; or  
White  lettering on gray  background  MEDICAL CARBON 
DIOXIDE; or                                                    CARBON  
DIOXIDE  USP 
Nitrogen  Black lettering on white background: 
or White  lettering on black  background  MEDICAL NITROGEN; 
or NITROGEN NF 
Nitrous  oxide  Blue lettering on white background; 
or White  lettering on blue  background  MEDICAL NITROUS OXIDE; 
or NITROUS OXIDE USP  
Oxygen  Green  lettering  on white  background;  or 
White  lettering on green  background  MEDICAL OXYGEN; 
or OXYGEN USP 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
DBZS 1: Part 8: 202X  
45 
 
 
 
 
 Appendix G  
Hazard and precautionary statements and codes  
(Normative)  
 
Table  G-1 lists the hazard  statements  identified  by code designations  in Appendices  D and E with 
their associated  signal  word, pictogram, and precautionary statement codes.  
 
Table  G-2 lists the  precautionary statements  as identified by  code designations  in Appendix  D 
and Table  G-1. 
 
Table  G-1: Hazard  Statement  Codes (HSC)  and associated  label  elements  
 
 
 
 
 
 
HSC   
 
 
 
 
Hazard  statement  
 
 
Signal  word  
 
 
Pictogram  Associated precautionary 
statement  
codes1) 
1) See Table G -2 for 
precautionary statements  required  
on all labels.  
2) This statement/group of 
statements is to be  used only on 
liquids.  
3) This hazard  statement  appears  
in Table  2.2.2  of the 7th Revised  
Edition  of GHS.  
 
GHS  Physical hazards  
 
H270   
MAY CAUSE OR 
INTENSIFY FIRE;  
OXIDIZER   
DANGER   
 P202; P220; P244; P370, 
P376;  P271+P403; CGA -
PG10; CGA -PG21: CGA -
PG22  
 
H280  CONTAINS GAS  UNDER  
PRESSURE; MAY 
EXPLODE IF  HEATED   
WARNING  
  
P202; P271+P403; CGA -
PG10; CGA -PG02  
 
H281  CONTAINS 
REFRIGERATED GAS;  
MAY CAUSE 
CRYOGENIC BURNS  OR 
INJURY   
WARNING   
  
P202; P282; P302, P336, 
P315; P 403; CGA -PG10; 
CGA -PG21: CGA -PG22  
GHS  Health  hazards  
 
H336   
MAY CAUSE 
DROWSINESS OR  
DIZZINESS   
WARNING  
  
P202; P233 2); P261; P304, 
P340, P312;  P271+P403;  
P405; P501  
 
Table  G-2—Precautionary  statement  codes  and text 
Precautionary  
statement code  Statement  
Required  on all labels  
 
DBZS 1: Part 8: 202X  
46 
 
 
 
 
 OSHA -PG01  DO NOT  REMOVE  THIS  PRODUCT  LABEL  (or equivalent  wording)  
P202  Do not handle until all safety  precautions have  been  read and  understood.  
CGA -PG05  Use a back  flow preventive  device  in the piping.  
CGA -PG06  Close  valve  after each use and when  empty.  
CGA -PG12  Do not open valve  until connected  to equipment  prepared for  use. 
CGA -PG27  Read  and follow the  Safety  Data Sheet  (SDS) before  use. 
Prevention  (GHS)  
P220  Keep  and store away  from  clothing  and other  combustible materials.  
P244  Keep  valves  and fittings  free from grease and  oil. 
P261  Avoid  breathing gas.  
P262  Do not get in  eyes, on  skin, or  on clothing.  
P271+P403  Use and store  only outdoors or  in a well-ventilated  place.  
P280  Wear  protective gloves,  protective  clothing,  and either eye  or face protection.  
P282  Wear  cold insulating  gloves,  face shield,  and eye protection.  
Prevention  (CGA)  
CGA -PG10  Use only with equipment  rated  for cylinder  pressure.  
CGA -PG17  Use only with equipment  purged with  inert gas  or evacuated  prior  to discharge from 
cylinder.  
CGA -PG20  Use only equipment  of compatible  materials  of construction.  
CGA -PG21  Open  valve  slowly.  
CGA -PG22  Use only with equipment  cleaned  for oxygen  service.  
CGA -PG24  DO NOT  change  or force  fit connections.  
CGA -PG26  Use insulated  hoses  and piping  to avoid  condensation  of oxygen -rich liquid  air. 
CGA -PG28  Avoid  spills.  Do not  walk  on or  roll equipment  over spills.  
Response  (GHS)  
P302  IF ON SKIN:  
P304  IF INHALED:  
P312  Call a POISON CENTER  or doctor/physician  if you feel unwell.  
P313  Get medical  advice/attention.  
P315  Get immediate  medical  advice/attention.  
P336  Thaw  frosted  parts  with lukewarm  water.  Do not rub affected  area.  
P340  Remove  person  to fresh air  and keep comfortable for  breathing.  
P370  In case of fire:  
P376  Stop leak if safe  to do  so. 
Storage  (GHS)  
P405  Store  locked  up. 
Storage  (CGA)  
CGA -PG02  Protect  from  sunlight  when  ambient  temperature  exceeds  52°C  (125°F).  
CGA -PG11  Never  put cylinders  into unventilated  areas  of passenger  vehicles.  
CGA -PG23  Always  keep  container  in upright  position.  
Disposal  (GHS)  
P501  Dispose  of contents/container  in accordance  with container  supplier/owner  instructions.  
2) This statement is to be used if immediate specific measures are required in accordance with OSHA's Hazard 
Communication Standard, Appendix C.4.3.  
 
 
  
DBZS 1: Part 8: 202X  
47 
 
 
 
 
 Annex  H 
CGA -recommended hazard and precautionary statements and  rules  for their  use 
(Normative)  
 
CGA  developed  hazard  and precautionary  statements,  as shown  in Tables  H-1 and H-2, to 
convey  additional  information  or to further  clarify the hazards and  the rules for  their use on 
labels  and SDSs.  
 
Table  H-1: Hazard  statement  codes,  text, and rules  for use 
 
 
HSC  STATEMENT  USED ON  
OSHA -H01 MAY  DISPLACE  OXYGEN  AND  CAUSE  RAPID  SUFFOCATION  Label  and SDS 
Rule for use: This OSHA hazard statement is required on any products with a hazard class of “Gases under pressure” and no  
classification for health hazards. This hazard statement is not used on pyrophorics, compressed air, oxygen/oxygen refrigerat ed, 
or oxygen  mixtures  with the oxygen  concentration greater  than 19.5%.  
 
CGA -HG01  MAY  CAUSE  FROSTBITE  Label  and SDS 
Rule for use: This CGA hazard statement is used on liquefied gases including toxics based on the state of gas because expo - sure 
to the gas and its latent  heat energy  transfer  is what  causes  frostbite.  
 
CGA -HG03  MAY  INCREASE RESPIRATION AND  HEART RATE.  Label  and SDS  
Rule for use: This CGA hazard statement is used on carbon dioxide and gas mixtures containing greater than or equal to 2%  
carbon dioxide.  
 
CGA -HG13  COMBUSTIBLES IN CONTACT WITH OXIDIZING REFRIGERATED 
LIQUIDS MAY  EXPLODE  ON IGNITION OR IMPACT  Label  and SDS 
  Rule  for use: This CGA  hazard  statement  is used on oxygen,  refrigerated  liquid,  and nitrous  oxide,  refrigerated  liquid.  
 
CGA -HG24  SUPPORTS  COMBUSTION  Label  and SDS 
Rule  for use: This CGA  hazard  statement  is only used on compressed  air. 
 
 
 
 
 
 
END OF DOCUMENT