G/SPS/N/CAN/1434  
 
28 April 2022  
(22-3375) Page: 1/2 
Committee on Sanitary and Phytosanitary Measures  Original: English/French  
 
  NOTIFICATION  
1. Notifying Member:  CANADA  
If applicable, name of local government involved:   
2. Agency responsible:  Health Canada  
3. Products covered (provide tariff item number(s) as specified in national 
schedules deposited with the WTO; ICS numbers should be provided in addition, 
where applicable):  Lipase from Mucor circinelloides f. circinelloides  AE-LM (ICS codes: 
67.220.20; 67.100.30)  
4. Regions or countries likely to be affected, to the extent relevant or practicable : 
[X] All trading partners   
[ ] Specific regions or countries:   
5. Title of the notified document:  Notice of Modification to the List of Permitted Food 
Enzymes  to Enable the Use of Lipase from Mucor circinelloides f. circinelloides  AE-LM in 
Certain Cheeses . Language(s):  English and French . Number of pages:  3 and 4  
https://members.wto.org/crnattachments/2022/SPS/CAN/22_3070_00_e.pdf  
https://members.wto.org/crnattachments/2022/SPS/CAN/22_3070_00_f.pdf  
6. Description of content:  Health Canada's Food Directorate completed a premarket safety 
assessment of a food additive submission seeking approval for the use of lipase from 
Mucor circinelloides f. circinelloides AE-LM in certain standardized cheeses, namely cheddar 
cheese and cheeses subject to the standard for (naming the variety) cheese.  
Lipase from other sources is already permitted for use in Canada in these cheeses, and 
lipase from M. circinelloides f. circinelloides (previous name: Mucor javanicus ) is also 
permitted for use in dairy -based flavouring preparations. However, prior to this Not ice, 
M. circinelloides f. circinelloides  AE-LM is a strain of this microorganism was not a 
permitted source for any food enzyme in Canada.  
The results of the premarket assessment support the safety of lipase from M. circinelloides 
f. circinelloides  AE-LM for its requested uses. Consequently, Health Canada has enabled 
the use of lipase from this source, as described in the information document, by modifying 
the List of Permitted Food Enzymes , effective 14 April 2022.  
The purpose of this communication is to p ublically announce the Department's decision in 
this regard and to provide the appropriate contact information for inquiries or for those 
wishing to submit new scientific information relevant to the safety of this food additive.  
7. Objective and rationale : [X]  food safety, [  ] animal health, [  ] plant protection, 
[ ] protect humans from animal/plant pest or disease, [  ] protect territory from 
other damage from pests.   G/SPS/N/CAN/1434  
 
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  8. Is there a relevant international standard? If so, identify the standard:  
[ ] Codex Alimentarius Commission (e.g.  title or serial number of Codex 
standard or related text) :  
[ ] World Organization for Animal Health (OIE) (e.g.  Terrestrial or Aquatic 
Animal Health Code, chapter number) :  
[ ] International Plant Protection Convention (e.g.  ISPM number) :  
[X] None  
Does this proposed regulation conform to the relevant international standard?  
[ ] Yes   [  ] No 
If no, describe, whenever possible, how and why it deviates from the 
international stand ard:  
9. Other relevant documents and language(s) in which these are available:  
Health  Canada's Food and Nutrition – 'Public Involvement and Partnerships' Website, 
posted 14 April 2022 (available in English and French):  
https://www.canada.ca/en/health -canada/services/food -nutrition/public -involvement -
partnerships.html  
https://www.canada.ca/fr/sante -canada/services/aliments -nutrition/participation -public -
partenariats.html  
10. Proposed date of adoption (dd/mm/yy) : 14 April 2022  
Proposed date o f publication (dd/mm/yy) :  
11. Proposed date of entry into force: [  ] Six months from date of publication , and/or  
(dd/mm/yy) : 14 April 2022  
[ ] Trade facilitating measure   
12. Final date for comments: [  ] Sixty days from the date of circulation of the 
notification and/or (dd/mm/yy) : 27 June 2022  
Agency or authority designated to handle comments: [  ] National Notification 
Authority, [X]  National Enquiry Point. Address, fax number and e -mail address (if 
avail able) of other body:   
13. Text(s) available from: [  ] National Notification Authority, [X]  National Enquiry 
Point. Address, fax number and e -mail address (if available) of other body:   
The "Notice of Modification to the List of Permitted Food Enzymes  to Enable the Use of 
Lipase from Mucor circinelloides f. circinelloides  AE-LM in Certain Cheeses" is available 
through the following weblink:  
https://www.canada.ca/en/health -canada/services/food -nutrition/public -involvement -
partnerships/notice -modification -list-permitted -food-enzymes -lipase -mucor -circinelloide -
certain -cheeses.html  (English)  
https://www.canada.ca/fr/sante -canada/services/aliments -nutrition/participation -public -
partenariats/avis -modification -liste-enzymes -alimentaires -autorisees -lipase -mucor -
circinelloides -certains -fromages.html  (French)  
 
Canada's Notification Auth ority and Enquiry Point  
Technical Barriers and Regulations Division  
Global Affairs Canada  
111 Sussex Drive  
Ottawa, Ontario, K1A 0G2  
Canada  
Tel: +(343) 203 4273  
Fax: +(613) 943 0346  
E-mail: enquirypoint@international.gc.ca