G/SPS/N/CAN/1549  
4 April 2024  
(24-2878) Page: 1/2 
Committee on Sanitary and Phytosanitary Measures  Original: English/French  
 
  NOTIFICATION  
1. Notifying Member:  CANADA  
If applicable, name of local government involved:   
2. Agency responsible:  Health Canada  
3. Products covered (provide tariff item number(s) as specified in national 
schedules deposited with the WTO; ICS numbers should be provided in addition, 
where applicable):  Chymosin B from Trichoderma reesei  GICC03546 (ICS codes: 
67.220.20)  
4. Regions or countries likely to be affected, to the extent relevant or practicable : 
[X] All trading partners   
[ ] Specific regions or countries:   
5. Title of the notified document:  Notice of Modification to the List of Permitted Food 
Enzymes  to Authorize the Use of Chymosin B from Trichoderma reesei  GICC03546 in Sour 
Cream and Various Cheeses . Language(s):  English and French . Number of pages:   
6. Description of content:  Health Canada's Food Directorate completed a premarket safety 
assessment of a food additive submission seeking authorization for the use of chymosin B 
from Trichoderma reesei  GICC03546 as a milk clotting enzyme in the manufacture of sour 
cream and various cheeses.  
The results of the premarket assessment support the safety of chymosin B from T. reesei  
GICC03546 for its requested use. Consequently, Health Canada has authorized the use of 
chymosin B from T. reesei  GICC03546 as described in the information docu ment 
referenced above by modifying the List of Permitted Food Enzymes , effective 22 Ma rch 
2024.  
The purpose of the information document is to publicly announce the Department's 
decision in this regard and to provide the appropriate contact information for those wishing 
to submit an inquiry or new scientific information relevant to the safet y of this food 
additive.  
7. Objective and rationale: [X]  food safety, [  ] animal health, [  ] plant protection, 
[ ] protect humans from animal/plant pest or disease, [  ] protect territory from 
other damage from pests.   
8. Is there a relevant international  standard? If so, identify the standard:  
[ ] Codex Alimentarius Commission (e.g.  title or serial number of Codex 
standard or related text) :  
[ ] World Organization for Animal Health (OIE) (e.g.  Terrestrial or Aquatic 
Animal Health Code, chapter number) :  
[ ] International Plant Protection Convention (e.g.  ISPM number) :  
[X] None  G/SPS/N/CAN/1549  
 
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  Does this proposed regulation conform to the relevant international standard?  
[ ] Yes   [  ] No 
If no, describe, whenever possible, how and why it deviates from the 
international standard:   
9. Other relevant documents and language(s) in which these are available:  
Health  Canada's Food and Nutrition – 'Public Involvement and Partnerships' Website, 
posted 22 March 2024 (available in English and French):  
https://www.canada.ca/en/health -canada/services/food -nutrition/public -involvement -
partnerships.html  (English ) 
https://www.canada.ca/fr/sante -canada/services/aliments -nutrition/participation -public -
partenariats.html  (French)  
10. Proposed date of adoption (dd/mm/yy) : The proposed food additive modification(s) 
will be legally enabled once published in Health Canada's Lists of Permitted Food Additives 
(https://www.canada.ca/en/health -canada/services/food -nutrition/food -safety/food -
additives/lists -permitted.html ). 
Proposed date of publication (dd/mm/yy) :  
11. Proposed date of entry into force: [  ] Six months from date of publication , and/or  
(dd/mm/yy) : The food additive modification(s) noted in this document come into force 
the day they are made to the Lists of Permitted Food Additives  
(https://www.canada.ca/en/health -canada/services/food -nutrition/food -safety/food -
additives/lists -permitted.html ). 
[ ] Trade facilitating measure   
12. Final date for comments: [  ] Sixty days from the date of circulation of the 
notification and/or (dd/mm/yy) : 5 June 2024  
Agency or authority designated to handle comments: [  ] National Notification 
Authority, [X]  National Enquiry Point. Address, fax number and e -mail address (if 
availa ble) of other body:   
13. Text(s) available from: [  ] National Notification Authority, [X]  National Enquiry 
Point. Address, fax number and e -mail address (if available) of other body:   
The Notice of Modification to the List of Permitted Food Enzymes  to Authorize the Use of 
Chymosin B from Trichoderma reesei  GICC03546 in Sour Cream and Various Cheeses is 
available through the following weblink:  
https://www.canada.ca/en/health -canada/services/food -nutrition/public -involvement -
partnerships/notice -modification -list-permitted -enzymes -authorize -chymosin -b-
trichoderma -reesei -gicc03546 -sour-cream -various -cheeses.html  (English)  
https://www.canada.ca/fr/sante -canada/services/aliments -nutrition/aliments -
genetiquement -modifies -autres -aliments -nouveaux/avis -modification -liste-enzymes -
autorisees -utilisation -chymosine -b-issue-trichoderma -reesei -gicc03546 -creme -sure-divers -
fromages.html  (French)  
Canada's Notification Authority and Enquiry Point  
Technical Barrier s and Regulations Division  
Global Affairs Canada  
111 Sussex Drive  
Ottawa, Ontario, K1A 0G2  
Canada  
Tel: +(343) 203 4273  
Fax: +(613) 943 0346  
E-mail: enquirypoint@international.gc.ca