COMMISSION IMPLEMENTING REGUL ATION (EU) 2022/672 
of 22 Apr il 2022
amending Implementing Regulation (EU) 2017/2470 as regards the specif ications of the novel food 
trans-resv eratrol (from microbial source) 
(Text with EEA relevance) 
THE EUR OPEAN COMMISSION,
Havi ng regar d to the Treaty on the Functioning of the European Union,
Havi ng regar d to Regulation (EU) 2015/2283 of the European Parliament and of the Council of 25 November 2015 on 
novel foods, amending Regulation (EU) No 1169/2011 of the European Parliament and of the Council and repealing 
Regulation (EC) No 258/97 of the European Parliament and of the Council and Commission Regulation (EC) 
No 1852/2001 (1), and in particular Article 12 thereof,
Whereas:
(1) Regulation (EU) 2015/2283 provides that only novel foods author ised and included in the Union list of novel foods 
may be placed on the mark et within the Union.
(2) Pursuant to Article 8 of Regulation (EU) 2015/2283, Commission Imple menting Regulation (EU) 2017/2470 (2)has 
established a Union list of novel foods.
(3) The Union list set out in the Annex to Implemen ting Regulation (EU) 2017/2470 includes trans-resveratrol from 
synthetic and microbial sources as an author ised novel food.
(4) The novel food trans-resveratrol from a microbial source has been author ised as a novel food ingredient under 
pursuant to Article 5 of Regulation (EC) No 258/97 of the European Parliament and of the Council (3)to be used in 
food supplements as defined in Directive 2002/46/EC of the European Parliament and of the Council (4), in capsule 
or tablet form, for the adult population on the basis of its substantial equivalence to resveratrol with a histor y of 
consum ption before 15 May 1997 extract ed from the Japanese knotweed (Fallopia japonica).
(5) Commission Implementing Decision (EU) 2016/1190 (5)author ised the placing on the Union mark et of synthetic 
trans-resveratrol as a novel food ingredient under Regulation (EC) No 258/97, also to be used in food supplements 
as defined in Directive 2002/46/EC in capsule or tablet form, for the adult population.
(6) Commission Implementing Regulation (EU) 2021/51 (6)amended the conditions of use of trans-resveratrol. In 
particular , the restr ictions on the deliver y formats of food supplements containing the novel food have been lifted.
(1)OJ L 327, 11.12.2015, p. 1.
(2)Commission Implementing Regulation (EU) 2017/2470 of 20 December 2017 establishing the Union list of novel foods in accordance 
with Regulation (EU) 2015/2283 of the European Parliament and of the Council on novel foods (OJ L 351, 30.12.2017, p. 72).
(3)Regulation (EC) No 258/97 of the European Parliament and of the Council of 27 Januar y 1997 concer ning novel foods and novel food 
ingredients (OJ L 43, 14.2.1997, p. 1).
(4)Directive 2002/46/EC of the European Parliament and of the Council of 10 June 2002 on the appro ximation of the laws of the 
Member States relating to food supplements (OJ L 183, 12.7.2002, p. 51).
(5)Commission Implementing Decision (EU) 2016/1190 of 19 July 2016 author ising the placing on the market of trans-resveratrol as a 
novel food ingredient under Regulation (EC) No 258/97 of the European Parliament and of the Council (OJ L 196, 21.7.2016, p. 53).
(6)Commission Implementing Regulation (EU) 2021/51 of 22 Januar y 2021 author ising a chang e of the conditions of use of the novel 
food ‘trans-resveratrol’ under Regulation (EU) 2015/2283 of the European Parliament and of the Council and amending Commission 
Implementing Regulation (EU) 2017/2470 (OJ, L 23, 25.1.2021, p. 10).EN Offi cial Jour nal of the European Union L 122/24 25.4.2022  (7) On 29 July 2021 , the compan y Evolva AG (‘the applicant ’) submitte d an application to the Commission in 
accordance with Article 10(1) of Regulation (EU) 2015/2283 for a chang e of the specifications of trans-resveratrol 
from a microbial source. The applicant request ed to remove the requirement that 100 % of the particles of the 
novel food produced by S. cerevisiae should be of a size less than 62,23 micrometres (< 62,23 μm).
(8) The applicant justifies the request by indicating that the change is necessar y in order to take account of the variation 
in the particle sizes of trans-resveratrol from a microbial source in the course of its production process and 
processing for use in food supplements. In suppor t of the request, the applicant provi ded analytical data 
demonstrating that the particle size prof ile of trans-resveratrol from a microbial source is compar able to the 
particle size prof ile of the chemically synthesised trans-resveratrol that was evaluated by the European Food Safet y 
Authority (‘the Author ity’) (7), and for which no particle size requirements are included in the Union list of novel 
foods.
(9) The Commission considers that the request ed update of the Union list is not liable to have an effect on human health 
and that a safety evaluation by the Author ity in accordance with Article 10(3) of Regulation (EU) 2015/2283 is not 
necessar y as the requeste d remo val of the particle size requirement for trans-resveratrol from a microbial source 
does not alter its safety profile because the analytical evidence submitte d by the applicant demonstrates that its 
particle size distr ibution prof ile is comparable to that of the chemically synthesised trans-resveratrol whic h was 
evaluated by the Auth ority.
(10) The information provid ed in the application gives sufficient grounds to establish that the request ed changes to the 
specifi cations of trans-resveratrol are in accordance with the conditions of Article 12 of Regulation (EU) 2015/2283 
and should be approved .
(11) The Annex to Implementing Regulation (EU) 2017/2470 should theref ore be amended according ly.
(12) The measures provid ed for in this Regulation are in accordance with the opinion of the Standing Committ ee on 
Plants, Animals, Food and Feed,
HAS ADOPTED THIS REGUL ATION:
Article 1
The Annex to Implementing Regulation (EU) 2017/2470 is amended in accordance with the Annex to this Regulation.
Article 2
This Regulation shall enter into force on the twentieth day followi ng that of its publication in the Official Journal of the 
European Union.
This Regulation shall be binding in its entirety and directly applicable in all Member States.
Done at Brussels, 22 Apr il 2022 .
For the Commission
The President
Ursula VON DER LEYEN
(7)EFSA Jour nal 2016;14(1):4368.EN Offi cial Jour nal of the European Union 25.4.2022 L 122/25  ANNEX 
In Table 2 (Specifications) of the Annex to Implementing Regulation (EU) 2017/2470 the entr y for trans-resveratrol is replaced by the followi ng:
Autho rised Novel Food Specifications
‘Trans-resveratrol Descr iption/Def inition:
Synthetic: Trans-resveratrol is off-white to beige crystals.
Chemical name: 5-[(E)-2-(4-hydro xyphenyl)ethen yl]benzene-1,3-diol
Chemical formula: C14H12O3
Molecular weight: 228,25 Da
CAS No: 501-36-0
Purity:
Trans-resveratrol: ≥ 98 %-99 %
Total by-products (relate d substances): ≤ 0,5 %
Any sing le related substance: ≤ 0,1 %
Sulphate d ash: ≤ 0,1 %
Loss on drying: ≤ 0,5 %
Hea vy metals :
Lead: ≤ 1,0 ppm
Mercur y: ≤ 0,1 ppm
Arsenic: ≤ 1,0 ppm
Impur ities:
Diisoprop ylamine: ≤ 50 mg/kg
Microbial source: A genetically modified strain of Sacchar omy ces cerevisiae
Appearance: Off-white to slight yello w powder
Trans-resveratrol content: Min. 98 % w/w (dry weight basis)
Ash: Max. 0,5 % w/w
Moisture: Max. 3 % w/w’EN Offi cial Jour nal of the European Union L 122/26 25.4.2022