ELI: http://data.europa.eu/eli/reg_impl/2023/2632/oj 1/3COMMISSION IMPLEMENTING REGUL ATION (EU) 2023/2632 
of 27 November 2023
concer ning the author isation of disodium 5′-inosinate produced by fermenta tion with 
Cor ynebacter ium stationis KCCM 80235 as a feed additiv e for all animal species 
(Text with EEA relevance) 
THE EUR OPEAN COMMISSION,
Havi ng regar d to the Treaty on the Functioning of the European Union,
Havi ng rega rd to Regulation (EC) No 1831/2003 of the European Parliament and of the Council of 22 Sept ember 2003 on 
additives for use in animal nutr ition (1), and in particular Article 9(2) thereof,
Whereas:
(1) Regulation (EC) No 1831/2003 provid es for the author isation of additives for use in animal nutr ition and for the 
grounds and procedures for granting such author isation.
(2) In accordance with Article 7 of Regulation (EC) No 1831/2003, an application was submitted for the author isation 
of disodium 5′-inosinate produced by fermentation with Corynebacter ium stationis KCCM 80235 for all animal 
species. The application was accompanied by the particulars and documents required under Article 7(3) of 
Regulation (EC) No 1831/2003.
(3) That application concer ns the author isation of disodium 5′-inosinate produced by fermentation with 
Corynebacter ium stationis KCCM 80235 as a feed additive for all animal species, requesting that additive to be 
classifie d in the additive categor y ‘sensor y additives ’ and in the functional group ‘flavouri ng compo unds ’. The 
applicant requested the additive to be author ised for use also in water for drinking. However , Regulation (EC) 
No 1831/2003 does not allow the author isation of ‘flavouri ng compounds’ for use in water for drinking. Theref ore, 
the use of this additive in wate r for drinking should not be allowed.
(4) The European Food Safety Author ity (‘the Author ity’) concluded in its opinions of 26 Januar y 2022 (2)and 21 March 
2023 (3)that, under the proposed conditions of use, disodium 5′-inosinate produced by fermentation with 
Corynebacter ium stationis KCCM 80235 is safe for all animal species, for consumers and for the environment. It 
concluded that disodium 5′-inosinate produced by fermentation with Corynebacter ium stationis KCCM 80235 should 
be considered not toxic by inhalation, not irritant to skin or eyes and not a dermal sensitiser . The Author ity further 
concluded that since disodium 5′-inosinat e produced by fermentation with Corynebacter ium stationis KCCM 80235 is 
recognised to flavour food and since its function in feed would be essentially the same as that in food, no further 
demonstration of efficacy is considered necessar y. The Author ity also verified the repor t on the method of analysis 
of the feed additive in feed submitted by the Reference Laborator y set up by Regulation (EC) No 1831/2003.
(5) In view of the above, the Commission considers that disodium 5′-inosinat e produced by fermentation with 
Corynebacter ium stationis KCCM 80235 satisfi es the conditions for author isation, as provid ed for in Article 5 of 
Regulation (EC) No 1831/2003. According ly, the use of that substance should be author ised.
(6) The measures provid ed for in this Regulation are in accordance with the opinion of the Standing Committ ee on 
Plants, Animals, Food and Feed,
(1)OJ L 268, 18.10.2003, p. 29.
(2)EFSA Journal 2022;20(3):7153.
(3)EFSA Journal 2023;21(4):7958.
Offi cial Jour nal  
of the European Union EN 
L series    
2023/2632  28.11.2023ELI: http://data.europa.eu/eli/reg_impl/2023/2632/oj 2/3HAS ADOPTED THIS REGUL ATION:
Article 1
Author isation
The substance specified in the Annex, belonging to the additive cate gory ‘sensor y additives’ and to the functional group 
‘flavouring compounds’, is author ised as an additive in animal nutr ition, subject to the conditions laid down in that Annex.
Article 2
Entr y into force
This Regulation shall enter into force on the twentieth day followi ng that of its publication in the Official Journal of the 
European Union.
This Regulation shall be binding in its entirety and directly applicable in all Member States.
Done at Brussels, 27 November 2023 .
For the Commission
The President
Ursula VON DER LEYENOJ L, 28.11.2023 EN  ELI: http://data.europa.eu/eli/reg_impl/2023/2632/oj 3/3ANNEX 
Identifica -
tion 
number of 
the additiveAdditiveComposition, chemical formula, descr iption, 
analytical methodSpecies or 
categor y of 
animalMaximum 
ageMinimum 
contentMaximum 
content
Other provisi onsEnd of period of 
author isationmg of active 
substance/kg of 
complet e feedingstuff 
with a moisture conten t 
of 12 %
Categor y: Sensor y additiv es. Functional group: Flav our ing compounds
2b631i Disodium 5′- 
inosinateAdditive composition:
Disodium 5′-inosinate
Solid form
Char acter isation of active substance:
Disodium 5′-inosinate produced by 
fermentation with Corynebacter ium stationis 
KCCM 80235
Purity: min. 97 % on dry matt er basis.
Chemical formula: 
C10H11O8N4Na 2P·7,5H 2O
CAS number: 4691-65-0
Analytical method (1):
For the identification of disodium 5'- 
inosinate (IMP) in the feed additive: FAO 
JECF A monograph ‘disodium 5'-inosinat e’
For the determination of disodium 5'- 
inosinate (IMP) in the feed additive, 
flavouring premixtures and water: – High 
performa nce liquid chromat ography 
coupled to UV detec tion (HPL C-UV)All animal 
species— — — 1. The additive shall be incor porated into 
the feed in the form of a premixture.
2. In the directions for use of the additive 
and premixtures, the storage conditions 
and stability to heat treatment shall be 
indicated .
3. On the label of the additive the following 
shall be indicated: ‘Recommended max ­
imum cont ent of the active substance 
alone or in combination with other 
author ised disodium 5′-r ibonucleotides: 
50 mg/kg of complet e feedingstuff with a 
moisture conte nt of 12 %’.
4. The functional group, the identification 
number , the name and the added amount 
of the active substance shall be indicated 
on the label of the premixture where the 
use level on the label of the premixture 
would result in exce eding the level re­
ferred to in point 3.18 December 2033
(1)Details of the analytical methods are available at the following address of the Reference Laborato ry: https://joint-research-centre.ec.europa.eu/eurl-f a-eurl-feedadditives/eurl-f a-author isation/eurl-f a-evaluation- 
repor ts_enOJ L, 28.11.2023 EN