Proposed Maximum Residue Limit  PMRL2019- 37 
Cyprodinil  
(publié aussi en français)  27 November 2019 
T
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Catalogue number:  H113- 24/2019-37E (print version)  
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Proposed Maximum Residue Limit - PMRL2019 -37 
Page 1 Under the authority of the Pest Control Products Act , Health Canada’s Pest Management 
Regulatory Agency (PMRA) has concluded that the addition of new uses on dried shelled pea 
and bean (except soybean) – crop sub group 6C to the product label s of Switch 62.5 WG  
Fungicide  and Cyproflu Fungicide , containing technical grade active ingredient s cyprodinil  and 
fludioxonil , is acceptable. The specific uses approved in Canada are detailed on the label s of 
Switch 62.5 WG Fungicide and Cyproflu Fungicide , Pest Control Products Act  Registration 
Number s 28189 and  30185, respectively . 
The evaluation of this cyprodinil  application indicated that the end- use product has value and the 
human health and environmental risks associated with the new use  are acceptable.  
Before registering a pesticide for food use in Canada, the PMRA must determi ne the quantity of 
residues that are likely to remain in or on the food when the pesticide is used according to label 
directions and that such residues will not be a concern to human health. This quantity is then 
legally established as a maximum residue li mit (MRL). An MRL applies to the identified raw 
agricultural food commodity as well as to any processed food product that contains it, except 
where separate MRLs are specified for the raw agricultural commodity and a processed product 
made from it.  
Consult ation on the proposed MRL for cyprodinil is being conducted via this document (see 
Next Steps). A summary of the field trial data used to support the proposed MRL can be found in 
Appendix I. MRL consultation for the other active ingredient, fludioxonil, pr esent in Switch 62.5 
WG Fungicide and Cyproflu Fungicide is being conducted under a separate action.  
To comply with Canada’s international trade obligations, c onsultation on the proposed MRL  is 
also being conducted internationally by  notifying the World Trade Organization , as coordinated 
by the Canada’s Notification Authority and Enquiry  Point . 
The proposed MRL , to be added to the  MRLs already established for cyprodinil , is as follows.  
Table 1  Proposed Maximum Residue Limit for Cyprodinil  
Common 
Name  Residue Definition  MRL (ppm)1 Food Commodity  
Cyprodinil  4-cyclopropyl -6-methy l-N-
phenyl -2-pyrimidinamine  0.62 Dried shelled pea and bean 
(except soybean)  (crop 
subgroup 6C)  
1 ppm = parts per million  
2 The 0.6 ppm MRL is proposed to be extended to all food commodities in crop subgroup 6C.    
 
Proposed Maximum Residue Limit - PMRL2019 -37 
Page 2 MRLs are proposed for each commodity included in the listed crop groupings in accordance with 
the Residue Chemistry Crop Groups  webpage in the Pesti cides and Pest Management section of  
the Canada.ca  website.  
MRLs established in Canada may be found using the  Maximum Residue Limit Database  on the 
Maximum Residue Limits for Pesticides  webpage . The database allows users to search for 
established MRLs, regulated under the Pest Control Products Act , both for pesticides or for food 
commodities.  
International Situation and Trade Implications  
MRLs may vary from one country to another for a number of reasons, including differences in 
pesticide  use patterns and the locations of the crop field trials used to generate residue chemistry 
data.  
Table 2 compares the MRL proposed for cyprodinil in Canada  with  the corresponding American 
tolerance and Codex MRL.1 American tolerances are listed in  the Electronic Code of Federal 
Regulations , 40 CFR Part 180, by  pesticide. A listing of established Codex MRL s is available on 
the Codex Alimentarius Pesticide Index  webpage, by pesticide or commodity.  
Table 2  Comparison of the Canadian MRL, American Tolerance and Codex MRL  
(where different)  
Food Commodity  Canadian MRL 
(ppm)  American Tolerance  
(ppm)  Codex MRL  
(ppm)  
Crop subgroup 6C  0.6 0.6 (dry beans)  0.2 (dry beans)  
 
Next Steps  
The PMRA invites the public to submit written comments on the proposed MRL for cyprodinil  
up to 75 days from the date of publication of this document. Please forward your comments to 
Publications (see the contact information on the cover page of this document). The PMRA will 
consider all comments received before making a final decision on the proposed MRL. C omments 
received will be addressed in a separate document link ed to this PMRL. The established MRL  
will be  legal ly in effect as of the date that it is entered into the Maximum Residue Limit 
Database .
                                                           
1  The Codex Alimentarius Commission  is an international organization under the auspices of the United 
Nations that develops international food standards, including MRLs.  Appendix I  
  
 
Proposed Maximum Residue Limit - PMRL2019 -37 
Page 3 Appendix  I 
Summary of Field Trial Data Used to Support the Proposed Maximum Residue L imits 
Residue data for cyprodinil in dry pea were submitted to support the domestic use of Switch 62.5 
WG Fungicide and Cyproflu Fungicide on crop subgroup 6C. In addition, previously reviewed 
residue data from field trials co nducted on dry beans were reassessed in the framework of this 
petition.  
Maximum Residue Limit(s)  
The recommendation for the maximum residue limit (MRL) for cyprodinil  was based upon the  
submitted field trial data , and the guidance provided in the OECD MRL Calculator . Table A1 
summarizes the residue data used to calculate the proposed MRL  for all commodities of crop 
subgroup 6C . 
Table A1 Summary of Field Trial Data Used to Support the MRL  
Commodity  Application 
Method/ Total 
Application Rate  
(g a.i./ha)1 Preharvest 
Interval  
(days)  Lowest 
Average Field 
Trial  Residues  
(ppm) Highest 
Average Field 
Trial Residues  
(ppm)  
Dry peas  Foliar application / 
1100  6–7 0.04 0.12 
Dry beans  Foliar application / 
1500  5–8 0.02 0.15 
1 g a.i./ha = grams of active ingredient  per hectare  
Following the review of all available data,  the MRL as proposed in Table 1 is  recommended to 
cover residues of cyprodinil. Residues of cyprodinil in these commodities at the proposed MRL 
will not pose an unacceptable risk to any segment of the population, including infants, children, 
adults and seniors.