# TBEV - InTraMoTick - Data Management Plan

Caroline Manet, Nolwenn Jouvenet, Sarah Bonnet

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Caroline Manet, Nolwenn Jouvenet, Sarah Bonnet. TBEV - InTraMoTick - Data Management Plan.
Institut Pasteur. 2025. hal-05344686

HAL Id: hal-05344686

https://hal.science/hal-05344686v1

Submitted on 3 Nov 2025

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<table><thead><tr><th colspan="3">TBEV - InTraMoTick</th></tr></thead><tbody><tr><td>1</td><td>Project Details</td><td></td></tr><tr><td>1.1</td><td>Project title</td><td>Exploring mechanisms of TBEV infection and transmission in mouse-tick models</td></tr><tr><td>1.2</td><td>Project acronym</td><td>TBEV - InTraMoTick</td></tr><tr><td>1.3</td><td>Project abstract</td><td>Tick-borne encephalitis (TBE) is a zoonotic disease caused by the flavivirus Tick-Borne Encephalitis Virus (TBEV), which is endemic in Europe and Asia. While TBEV is primarily transmitted through tick bites to humans and animals, transmission through consumption of raw milk or dairy products from infected farm animals is also possible. TBEV targets the central nervous system, with a fatality rate ranging from 1-5%, and can lead to mild to severe neurological complications with potential long-term effects. Although a vaccine is available, the increasing incidence of TBE in Europe, combined with the virus's expanding geographical range, identifies TBEV as an emerging public health concern. The variable severity observed in humans strongly suggests a role of host genetic variants, which could also modulate the efficacy of virus transmission between the vector and the mammalian host. However, investigating these variants is challenging due to the limited number of cases available for study. While mice serve as valuable models for studying flavivirus infections, existing models of TBE fail to accurately replicate the full spectrum of human disease manifestations. The objectives of our project are to exploit mouse genetic diversity to unravel the intricate mechanisms underlying variations in susceptibility to TBEV infection and transmission, with a focus on disease pathophysiology, antiviral defenses, and transmissibility to tick vectors. Specifically, we aim (1) to characterize TBEV infection in diverse mouse genetic backgrounds to produce a variety of mouse models spanning the range of human TBE presentations, (2) to uncover immune mechanisms driving differences in disease severity by identifying the most effective murine Interferon stimulated genes (ISGs) against TBEV, and (3) to assess variations in tick-to-mouse and mouse-to-tick transmission due to mouse genetic diversity.</td></tr><tr><td>1.4</td><td>Project funder(s)</td><td>PTR Institut Pasteur</td></tr><tr><td>1.5</td><td>Grant identifier</td><td>#1784</td></tr><tr><td>1.6</td><td>Project start date</td><td>01/01/2025</td></tr><tr><td>1.7</td><td>Project end date</td><td>31/12/2026</td></tr><tr><td>1.8</td><td>List the partners associated with the project</td><td>Partner 1: Institut Pasteur (Mouse Genetics Laboratory)<br>Partner 2: Institut Pasteur (Virus sensing and Signaling Unit)<br>Partner 3: Institut Pasteur (Ecology and Emergence of Arthropod-borne Pathogens Unit)</td></tr><tr><td>1.9</td><td>Project coordinator, research unit, institution and ORCID</td><td>Caroline Manet, Mouse Genetics Laboratory, Institut Pasteur (https://orcid.org/0000-0002-7730-8818)</td></tr><tr><td>2</td><td>Data Management Plan (DMP) Information</td><td></td></tr><tr><td>2.1</td><td>DMP manager(s)</td><td>Caroline Manet (https://orcid.org/0000-0002-7730-8818)</td></tr><tr><td>2.2</td><td>DMP version</td><td>First version</td></tr><tr><td>2.3</td><td>Date of the current version of the DMP</td><td>2025-02-20</td></tr><tr><td>2.4</td><td>Version history</td><td>First version: 20/02/2025 (stored on an internal server)</td></tr><tr><td>2.5</td><td>If the DMP is published: URL or identifier of the DMP and license</td><td></td></tr></tbody></table>
<table><thead><tr><th></th><th></th><th></th><th></th><th></th><th></th><th></th><th></th><th></th></tr></thead><tbody><tr><td>2.2.1</td><td>Describe the general legal issues of your project</td><td>The consortium agreement defines who owns the data and therefore who controls the dissemination of the data each partner owns (the data it produces).</td><td>The consortium agreement defines who owns the data and therefore who controls the dissemination of the data each partner owns the data it produces.</td><td>The consortium agreement defines who owns the data and therefore who controls the dissemination of the data each partner owns the data it produces.</td><td>The consortium agreement defines who owns the data and therefore who controls the dissemination of the data each partner owns the data it produces.</td><td>The consortium agreement defines who owns the data and therefore who controls the dissemination of the data each partner owns the data it produces.</td><td>The consortium agreement defines who owns the data and therefore who controls the dissemination of the data each partner owns the data it produces.</td></tr><tr><td>2.2.2</td><td>Indicate the reference(s) of documents related to legal aspects</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td></tr><tr><td>2.2.3</td><td>Identify legal experts</td><td>Consortium</td><td>Consortium</td><td>Consortium</td><td>Consortium</td><td>Consortium</td><td>Consortium</td></tr><tr><td>3.5</td><td colspan="8">What ethical issues and codes of conduct are there, and how will they be taken into account?</td></tr><tr><td>3.5.1</td><td>Describe the ethical issues</td><td>The ethical issue identified (legal) welfare has no impact on data management.</td><td>The ethical issue identified (legal) welfare has no impact on data management.</td><td>The ethical issue identified (legal) welfare has no impact on data management.</td><td>N/A</td><td>N/A</td><td>N/A</td></tr><tr><td>3.5.2</td><td>Indicate the reference(s) of documents related to ethical issues</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td></tr><tr><td>3.5.3</td><td>Persons in charge of ethical issues</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td></tr><tr><td colspan="8">4. Data processing and analysis</td></tr><tr><td>4.1</td><td colspan="8">How and with what resources will the data be processed / analysed?</td></tr><tr><td>4.1.1</td><td>Describe data processing methods or protocols</td><td>Data formatting and statistical analysis on R</td><td>Image analysis on Zen Software (Disc) and/or ImageJ</td><td>Data formatting and statistical analysis on R</td><td>Data formatting and statistical analysis on R</td><td>Data formatting and statistical analysis on R</td><td>Data formatting and statistical analysis on R</td></tr><tr><td>4.1.2</td><td>Indicate related references</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td></tr><tr><td>4.1.3</td><td>Equipment, technical platform(s) used for data processing and statistics</td><td>N/A</td><td>MicroPathology Core Facility working space</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td></tr><tr><td>4.1.4</td><td>Research data processing and analysis data</td><td>Partner 1</td><td>MicroPathology Core Facility, Partner 1 and Partner 2</td><td>Partner 1 and Partner 2</td><td>Partner 1 and Partner 1</td><td>Partner 2 and Partner 1</td><td>Partner 2 and Partner 1</td></tr><tr><td>4.1.5</td><td>Data treatment/analysis associated costs</td><td>N/A</td><td>Costs related to the use of the microPathology Core Facility's equipment and services</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td></tr><tr><td colspan="8">5. Storage and backing during the research process</td></tr><tr><td>5.1</td><td colspan="8">How will data be stored and backed up during the research?</td></tr><tr><td>5.1.1</td><td>Describe storage needs</td><td>At the start of the project, a dedicated Data project space (DD0000) was set up on the Institut "Pierre" storage servers to facilitate data storage and sharing among partners.</td><td>At the start of the project, a dedicated Data project space (DD0000) was set up on the Institut "Pierre" storage servers to facilitate data storage and sharing among partners.</td><td>At the start of the project, a dedicated Data project space (DD0000) was set up on the Institut "Pierre" storage servers to facilitate data storage and sharing among partners.</td><td>At the start of the project, a dedicated Data project space (DD0000) was set up on the Institut "Pierre" storage servers to facilitate data storage and sharing among partners.</td><td>At the start of the project, a dedicated Data project space (DD0000) was set up on the Institut "Pierre" storage servers to facilitate data storage and sharing among partners.</td><td>At the start of the project, a dedicated Data project space (DD0000) was set up on the Institut "Pierre" storage servers to facilitate data storage and sharing among partners.</td></tr><tr><td>5.1.2</td><td>Estimated volume of data</td><td>1-6 Gb</td><td>1-6 Gb</td><td>1-6 Gb</td><td>1-6 Gb</td><td>1-6 Gb</td><td>1-6 Gb</td></tr><tr><td>5.1.3</td><td>Equipment, technical platform(s) used for data storage and sharing</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td><td>N/A</td></tr><tr><td>5.1.4</td><td>Logistics policy (backup type and frequency, storage format)</td><td>This data is stored on a non-replicated server space from the Institut "Pierre" (DD0000).</td><td>This data is stored on a non-replicated server space from the Institut "Pierre" (DD0000).</td><td>This data is stored on a non-replicated server space from the Institut "Pierre" (DD0000).</td><td>This data is stored on a non-replicated server space from the Institut "Pierre" (DD0000).</td><td>This data is stored on a non-replicated server space from the Institut "Pierre" (DD0000).</td><td>This data is stored on a non-replicated server space from the Institut "Pierre" (DD0000).</td></tr><tr><td>5.1.5</td><td>Describe the measures taken to ensure data security</td><td>These data are not sensitive. No special security measures are necessary.</td><td>These data are not sensitive. No special security measures are necessary.</td><td>These data are not sensitive. No special security measures are necessary.</td><td>These data are not sensitive. No special security measures are necessary.</td><td>These data are not sensitive. No special security measures are necessary.</td><td>These data are not sensitive. No special security measures are necessary.</td></tr><tr><td>5.1.6</td><td>Person(s) in charge of storage</td><td>Partner 1</td><td>Partner 1</td><td>Partner 1</td><td>Partner 1 and Partner 2</td><td>Partner 2 and Partner 1</td><td>Partner 2 and Partner 1</td></tr><tr><td>5.1.7</td><td>Data storage and backup associated costs</td><td>Nominal costs due to low data volume</td><td>Nominal costs due to low data volume</td><td>Nominal costs due to low data volume</td><td>Nominal costs due to low data volume</td><td>Nominal costs due to low data volume</td><td>Nominal costs due to low data volume</td></tr><tr><td colspan="8">6. Data sharing and sharing level management</td></tr><tr><td>6.1</td><td colspan="8">How will data be shared?</td></tr><tr><td>6.1.1</td><td>Describe the modelling of sharing</td><td>1) This dataset will be made freely available at the time of publication of the associated article.<br>2) It will be deposited in the MicroPathology Database.<br>3) The license associated with this dataset will be a CC-BY license.</td><td>1) This dataset will be made freely available at the time of publication of the associated article.<br>2) It will be deposited in the MicroPathology Database or Image Data Resource (in be determined).<br>3) The license associated with this dataset will be a CC-BY license.</td><td>1) This dataset will be made freely available at the time of publication of the associated article.<br>2) The license associated with this dataset will be a CC-BY license.</td><td>1) This dataset will be made freely available at the time of publication of the associated article.<br>2) The license associated with this dataset will be a CC-BY license.</td><td>1) This dataset will be made freely available at the time of publication of the associated article.<br>2) The license associated with this dataset will be a CC-BY license.</td><td>1) This dataset will be made freely available at the time of publication of the associated article.<br>2) The license associated with this dataset will be a CC-BY license.</td></tr><tr><td>6.1.2</td><td>Modularity</td><td>This dataset could be used for a meta-analysis.</td><td>This dataset could be used for a meta-analysis.</td><td>This dataset could be used for a meta-analysis.</td><td>This dataset could be used for a meta-analysis.</td><td>N/A</td><td>N/A</td></tr><tr><td>6.1.3</td><td>Repository and/or catalogue chosen to store or display data</td><td>MicroPathology Database</td><td>MicroPathology Archive or Image Data Resource (in be determined).</td><td>Be determined</td><td>Be determined</td><td>Be determined</td><td>Be determined</td></tr><tr><td>6.1.4</td><td>Person(s) in charge of data deposition and diffusion</td><td>Partner 1</td><td>Partner 1</td><td>Partner 1</td><td>Partner 1 and Partner 2</td><td>Partner 2 and Partner 1</td><td>Partner 2 and Partner 1</td></tr><tr><td>6.1.5</td><td>Data sharing associated costs</td><td>The repository is free of charge. Costs are linked to the time spent documenting the data before it is made available.</td><td>The repository is free of charge. Costs are linked to the time spent documenting the data before it is made available.</td><td>The repository is free of charge. Costs are linked to the time spent documenting the data before it is made available.</td><td>The repository is free of charge. Costs are linked to the time spent documenting the data before it is made available.</td><td>The repository is free of charge. Costs are linked to the time spent documenting the data before it is made available.</td><td>The repository is free of charge. Costs are linked to the time spent documenting the data before it is made available.</td></tr><tr><td>6.2</td><td colspan="8">How will data be long term preserved? Which data?</td></tr><tr><td>6.2.1</td><td>Long-term preservation justification</td><td>The raw data must be preserved because of the difficulties of reproducibility and the time required to represent them. This is essential to ensure the reproducibility of the results presented in publications and to be able to compare them with the data that will be generated at a later date.</td><td>The raw data must be preserved because of the difficulties of reproducibility and the time required to represent them. This is essential to ensure the reproducibility of the results presented in publications and to be able to compare them with the data that will be generated at a later date.</td><td>The raw data must be preserved because of the difficulties of reproducibility and the time required to represent them. This is essential to ensure the reproducibility of the results presented in publications and to be able to compare them with the data that will be generated at a later date.</td><td>The raw data must be preserved because of the difficulties of reproducibility and the time required to represent them. This is essential to ensure the reproducibility of the results presented in publications and to be able to compare them with the data that will be generated at a later date.</td><td>The raw data must be preserved because of the difficulties of reproducibility and the time required to represent them. This is essential to ensure the reproducibility of the results presented in publications and to be able to compare them with the data that will be generated at a later date.</td><td>The raw data must be preserved because of the difficulties of reproducibility and the time required to represent them. This is essential to ensure the reproducibility of the results presented in publications and to be able to compare them with the data that will be generated at a later date.</td></tr><tr><td>6.2.2</td><td>Estimated volume of data</td><td>1-6 Gb</td><td>1-6 Gb</td><td>1-6 Gb</td><td>1-6 Gb</td><td>1-6 Gb</td><td>1-6 Gb</td></tr><tr><td>6.2.3</td><td>Operation of retention (start and end date) if applicable</td><td>Archived data will be kept for the maximum period permitted by Institut "Pierre"'s archiving system.</td><td>Archived data will be kept for the maximum period permitted by Institut "Pierre"'s archiving system.</td><td>Archived data will be kept for the maximum period permitted by Institut "Pierre"'s archiving system.</td><td>Archived data will be kept for the maximum period permitted by Institut "Pierre"'s archiving system.</td><td>Archived data will be kept for the maximum period permitted by Institut "Pierre"'s archiving system.</td><td>Archived data will be kept for the maximum period permitted by Institut "Pierre"'s archiving system.</td></tr><tr><td>6.2.4</td><td>Choose as a factor for long-term data preservation</td><td>Institut "Pierre"'s long-term archiving system</td><td>Institut "Pierre"'s long-term archiving system</td><td>Institut "Pierre"'s long-term archiving system</td><td>Institut "Pierre"'s long-term archiving system</td><td>Institut "Pierre"'s long-term archiving system</td><td>Institut "Pierre"'s long-term archiving system</td></tr><tr><td>6.2.5</td><td>Person(s) in charge of long-term data preservation</td><td>Caroline Manet (Partner 1) + Institut "Pierre"'s Archives Unit</td><td>Caroline Manet (Partner 1) + Institut "Pierre"'s Archives Unit</td><td>Caroline Manet (Partner 1) + Institut "Pierre"'s Archives Unit</td><td>Sarah Bonnet (Partner 1) + Caroline Manet (Partner 1) + Institut "Pierre"'s Archives Unit</td><td>Nevenleuven (Partner 1) + Caroline Manet (Partner 1) + Institut "Pierre"'s Archives Unit</td><td>Nevenleuven (Partner 1) + Caroline Manet (Partner 1) + Institut "Pierre"'s Archives Unit</td></tr><tr><td>6.2.6</td><td>Long-term data preservation associated costs</td><td>The cost of long-term preservation is covered by the Institut "Pierre". The costs are related to the time spent selecting the data, reorganizing it and documenting it before archiving.</td><td>The cost of long-term preservation is covered by the Institut "Pierre". The costs are related to the time spent selecting the data, reorganizing it and documenting it before archiving.</td><td>The cost of long-term preservation is covered by the Institut "Pierre". The costs are related to the time spent selecting the data, reorganizing it and documenting it before archiving.</td><td>The cost of long-term preservation is covered by the Institut "Pierre". The costs are related to the time spent selecting the data, reorganizing it and documenting it before archiving.</td><td>The cost of long-term preservation is covered by the Institut "Pierre". The costs are related to the time spent selecting the data, reorganizing it and documenting it before archiving.</td><td>The cost of long-term preservation is covered by the Institut "Pierre". The costs are related to the time spent selecting the data, reorganizing it and documenting it before archiving.</td></tr></tbody></table>