# The challenge of exploring neuropsychiatric and cognitive symptoms after spontaneous intracerebral hemorrhage.

Giuseppe Scopelliti, Charlotte Cordonnier, Leonardo Pantoni

► To cite this version:

Giuseppe Scopelliti, Charlotte Cordonnier, Leonardo Pantoni. The challenge of exploring neuropsychiatric and cognitive symptoms after spontaneous intracerebral hemorrhage. European Journal of Neurology, 2024, European Journal of Neurology, 32 (1), pp.e16585. 10.1111/ene.16585. hal-05301875

HAL Id: hal-05301875

https://lilloa.hal.science/hal-05301875v1

Submitted on 7 Oct 2025

HAL is a multi-disciplinary open access
archive for the deposit and dissemination of sci-
entific research documents, whether they are pub-
lished or not. The documents may come from
teaching and research institutions in France or
abroad, or from public or private research centers.

L'archive ouverte pluridisciplinaire HAL, est
destinée au dépôt et à la diffusion de documents
scientifiques de niveau recherche, publiés ou non,
émanant des établissements d'enseignement et de
recherche français ou étrangers, des laboratoires
publics ou privés.

<figure><img src="image_1.png" /></figure>

Distributed under a Creative Commons Attribution 4.0 International License
EDITORIAL

european journal
of neurology

The official journal of the european academy of neurology

# The challenge of exploring neuropsychiatric and cognitive symptoms after spontaneous intracerebral hemorrhage

Spontaneous intracerebral hemorrhage (ICH) is an extremely dangerous condition, with overall greater social-economic burden than ischemic stroke despite lower incidence. Approximately half of patients with acute ICH do not survive beyond the first year, and those who do often face significant, lasting disability [1]. Qiuyi Jiang et al. investigated one of the more subtle long-term effects of ICH, the affective and cognitive symptoms that have been often overlooked by stroke neurologists, but are an especially pressing burden for patients and their caregivers [2, 3]. This study, conducted in China, included nearly 1600 patients, marking the largest cohort on this topic to date. However, the majority of participants had deep ICH (85%) and were relatively young (median age 57 years), limiting the generalizability of the findings to older populations with lobar ICH.

Although the study explicitly focused on "small" ICHs (median volume of 10mL), it should be noted that the majority of previous studies on long-term cognitive and neuropsychiatric outcomes of ICH have also predominantly included patients with smaller hematoma volumes [4, 5]. This is mainly because larger hemorrhages are associated with poor short-term survival, or patients are less likely to be able to attend outpatient clinic for long term follow-up. Similar considerations can be made regarding studies on the long-term cognitive consequences of ischemic stroke, in which patients with more severe events and language impairment are often excluded, resulting in an unavoidable bias in evaluating long-term trajectories [6]. Nevertheless, we might hypothesize that those patients suffering from lower levels of disability after the index event are probably the ones who are going to benefit the most from a long-term stroke neuropsychiatric and cognitive follow-up.

Given that most studies have predominantly focused on small ICHs, our understanding of the cognitive and neuropsychiatric consequences of ICH survivors so far may reflect more the influence of the underlying cerebral small vessel disease (e.g., arteriolosclerosis and cerebral amyloid angiopathy) rather than the direct impact of the initial ICH event. Although this study did not assess MRI features of cerebral small vessel disease, the authors found that potentially modifiable factors related to ICH at baseline (e.g., blood pressure levels, length of hospitalization, and anteroposterior diameter of the index ICH) could influence long-term cognitive and affective outcomes. This finding underscores the importance of consistently

including cognitive and affective measures as outcome variables in clinical trials of acute phase interventions.

Another important catch on the current topic is the complex presentation of affective symptoms following an ICH, and, more broadly, in patients with cerebrovascular diseases. Qiuyi Jiang and colleagues adopted a pragmatic approach, using both in-hospital and telephone-based assessments to evaluate patients' cognitive and affective status. While this method may boost neuropsychiatric screening rates, categorizing a patient as simply having depressive or anxiety symptoms may not capture the full complexity of the neuropsychiatric profile, especially as growing evidence shows that different mood and cognitive manifestations are often interlinked and comorbid. We now recognize that the neuropsychiatric profile may reflect both the structural integrity and age-related changes of the brain (e.g., neurodegeneration, vascular burden), offering insights into the cognitive status of patients with stroke [5, 7]. This understanding is especially important when evaluating post-ICH depression, as different neuropsychiatric patterns may be present under the general category of depressive symptoms; for example, identifying apathetic traits alongside mood disturbances could help to pinpoint the patients at greater risk for cognitive impairment [8]. The tools currently used in clinical practice do not adequately capture the nuanced neuropsychiatric status of cerebrovascular patients: developing new, multidimensional screening instruments to better assess this complexity remains a significant challenge for the future.

AUTHOR CONTRIBUTIONS

Giuseppe Scopelliti: Conceptualization; writing - original draft.

Charlotte Cordonnier: Writing - review and editing; conceptualization.
Leonardo Pantoni: Writing - review and editing; conceptualization.

CONFLICT OF INTEREST STATEMENT

None.

DATA AVAILABILITY STATEMENT

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

This is an open access article under the terms of the [Creative Commons Attribution](https://creativecommons.org/licenses/by) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

© 2024 The Author(s). *European Journal of Neurology* published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.
Giuseppe Scopelliti¹ ID

Charlotte Cordonnier² ID

Leonardo Pantoni³,⁴ ID

¹Neurology Unit, Luigi Sacco University Hospital, Milan, Italy

²Univ. Lille, Inserm U1172 - Lille Neuroscience & Cognition, CHU-Lille, Lille, France

³Department of Biomedical and Clinical Sciences, Neuroscience Research Center, University of Milan, Milan, Italy

⁴Department of Neurorehabilitation Sciences, Casa di Cura Igea, Milan, Italy

Correspondence

Giuseppe Scopelliti, Neurology Unit, Luigi Sacco University Hospital, Milan, Italy.

Email: giuseppescopelliti.gs@gmail.com

ORCID

Giuseppe Scopelliti ID https://orcid.org/0000-0002-2313-2124

Charlotte Cordonnier ID https://orcid.org/0000-0002-5697-6892

Leonardo Pantoni ID https://orcid.org/0000-0001-7357-8530

REFERENCES

1. Puy L, Parry-Jones AR, Sandset EC, Dowlatshahi D, Ziai W, Cordonnier C. Intracerebral haemorrhage. *Nat Rev Dis Primers*. 2023;9:1. doi:10.1038/s41572-023-00424-7

2. Kim KT, Chang WK, Jung YS, et al. Unmet needs for rehabilitative management in common health-related problems negatively impact the quality of life of community-dwelling stroke survivors. *Front Neurol*. 2021;12:2440. doi:10.3389/FNEUR.2021.758536/BIBTEX

3. Jiang Q, Liu C, Zhang H, et al. Predictors of affective disturbances and cognitive impairment following small spontaneous supraturorial intracerebral hemorrhage. *Eur J Neurol*. Published online 2024;e16544.

4. Biffi A, Bailey D, Anderson CD, et al. Risk factors associated with early vs delayed dementia after intracerebral hemorrhage. *JAMA Neurol*. 2016;73(8):969-976. doi:10.1001/JAMANEUROL.2016.0955

5. Scopelliti G, Casolla B, Boulouis G, et al. Long-term neuropsychiatric symptoms in spontaneous intracerebral haemorrhage survivors. *J Neurol Neurosurg Psychiatry*. 2022;93(3):232-237. doi:10.1136/JNNP-2021-327557

6. Pendlebury ST, Chen PJ, Bull L, Silver L, Mehta Z, Rothwell PM. Methodological factors in determining rates of dementia in transient ischemic attack and stroke: (I) impact of baseline selection bias. *Stroke*. 2015;46(3):641-646. doi:10.1161/STROKEAHA.114.008043

7. Tay J, Morris RG, Tuladhar AM, Husain M, De Leeuw FE, Markus HS. Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease. *J Neurol Neurosurg Psychiatry*. 2020;91(9):953-959. doi:10.1136/jnnp-2020-323092

8. Scopelliti G, Kyheng M, Casolla B, et al. Depressive symptoms profile and dementia risk after spontaneous intracerebral haemorrhage. *Eur Stroke J*. 2024. Online ahead of print. doi:10.1177/23969873241284725