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169. Zhu, S.; Ding, S.; Wang, P.; Wei, Z.; Pan, W.; Palm, N.W.; Yang, Y.; Yu, H.; Li, H.B.; Wang, G.; et al. Nlrp9b Inflammasome Restricts Rotavirus Infection in Intestinal Epithelial Cells. *Nature* **2017**, *546*, 667–670. [CrossRef]

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159. Yang, Y.; Lang, X.; Sun, S.; Gao, C.; Hu, J.; Ding, S.; Li, J.; Li, Y.; Wang, F.; Gong, T. Nlrp2 Negatively Regulates Antiviral Immunity by Interacting with Tbk1. *Eur. J. Immunol.* **2018**, *48*, 1817–1825. [CrossRef]

160. Pothlichet, J.; Meunier, I.; Davis, B.K.; Ting, J.P.; Skamene, E.; von Messling, V.; Vidal, S.M. Type I Ifn Triggers Rig-I/Tlr3/Nlrp3-Dependent Inflammasome Activation in Influenza a Virus Infected Cells. *PLoS Pathog.* **2013**, *9*, e1003256. [CrossRef]

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163. Lian, Y.G.; Zhao, H.Y.; Wang, S.J.; Xu, Q.L.; Xia, X.J. Nlrp4 Is an Essential Negative Regulator of Fructose-Induced Cardiac Injury in Vitro and in Vivo. *Biomed. Pharm.* **2017**, *91*, 590–601. [CrossRef] [PubMed]

164. Cui, J.; Li, Y.; Zhu, L.; Liu, D.; Songyang, Z.; Wang, H.Y.; Wang, R.F. Nlrp4 Negatively Regulates Type I Interferon Signaling by Targeting the Kinase Tbk1 for Degradation Via the Ubiquitin Ligase Dtx4. *Nat. Immunol.* **2012**, *13*, 387–395. [CrossRef] [PubMed]

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167. Hara, H.; Seregin, S.S.; Yang, D.; Fukase, K.; Chamaillard, M.; Alnemri, E.S.; Inohara, N.; Chen, G.Y.; Nunez, G. The Nlrp6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. *Cell* **2018**, *175*, 1651–1664. [CrossRef]

168. Wang, P.; Zhu, S.; Yang, L.; Cui, S.; Pan, W.; Jackson, R.; Zheng, Y.; Rongvaux, A.; Sun, Q.; Yang, G.; et al. Nlrp6 Regulates Intestinal Antiviral Innate Immunity. *Science* **2015**, *350*, 826–830. [CrossRef]

169. Zhu, S.; Ding, S.; Wang, P.; Wei, Z.; Pan, W.; Palm, N.W.; Yang, Y.; Yu, H.; Li, H.B.; Wang, G.; et al. Nlrp9b Inflammasome Restricts Rotavirus Infection in Intestinal Epithelial Cells. *Nature* **2017**, *546*, 667–670. [CrossRef]

170. Ellwanger, K.; Becker, E.; Kienes, I.; Sowa, A.; Postma, Y.; Gloria, Y.C.; Weber, A.N.R.; Kufer, T.A. The Nlr Family Pyrin Domain-Containing 11 Protein Contributes to the Regulation of Inflammatory Signaling. *J. Biol. Chem.* **2018**, *293*, 2701–2710. [CrossRef]

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271. Veeranki, S.; Duan, X.; Panchanathan, R.; Liu, H.; Choubey, D. Ifi16 Protein Mediates the Anti-Inflammatory Actions of the Type-I Interferons through Suppression of Activation of Caspase-1 by Inflammasomes. *PLoS ONE* **2011**, *6*, e27040. [CrossRef]
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293. Weiss, E.S.; Girard-Guyonvarc'h, C.; Holzinger, D.; de Jesus, A.A.; Tariq, Z.; Picarsic, J.; Schiffrin, E.J.; Foell, D.; Grom, A.A.; Ammann, S.; et al. Interleukin-18 Diagnostically Distinguishes and Pathogenically Promotes Human and Murine Macrophage Activation Syndrome. *Blood* **2018**, *131*, 1442–1455. [CrossRef] [PubMed]

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273. Hernandez-Cuellar, E.; Tsuchiya, K.; Hara, H.; Fang, R.; Sakai, S.; Kawamura, I.; Akira, S.; Mitsuyama, M. Cutting Edge: Nitric Oxide Inhibits the Nlrp3 Inflammasome. *J. Immunol.* **2012**, *189*, 5113–5117. [CrossRef] [PubMed]

274. Thomas, P.G.; Dash, P.; Aldridge, J.R., Jr.; Ellebedy, A.H.; Reynolds, C.; Funk, A.J.; Martin, W.J.; Lamkanfi, M.; Webby, R.J.; Boyd, K.L.; et al. The Intracellular Sensor Nlrp3 Mediates Key Innate and Healing Responses to Influenza a Virus Via the Regulation of Caspase-1. *Immunity* **2009**, *30*, 566–575. [CrossRef] [PubMed]

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278. Chen, I.Y.; Moriyama, M.; Chang, M.F.; Ichinohe, T. Severe Acute Respiratory Syndrome Coronavirus 3a Activates the Nlrp3 Inflammasome. *Front. Microbiol.* **2019**, *10*, 50. [CrossRef]

279. Park, S.; Juliana, C.; Hong, S.; Datta, P.; Hwang, I.; Fernandes-Alnemri, T.; Yu, J.W.; Alnemri, E.S. The Mitochondrial Antiviral Protein Mavs Associates with Nlrp3 and Regulates Its Inflammasome Activity. *J. Immunol.* **2013**, *191*, 4358–4366. [CrossRef]

280. Subramanian, N.; Natarajan, K.; Clatworthy, M.R.; Wang, Z.; Germain, R.N. The Adaptor Mavs Promotes Nlrp3 Mitochondrial Localization and Inflammasome Activation. *Cell* **2013**, *153*, 348–361. [CrossRef]

281. Crow, Y.J.; Manel, N. Aicardi-Goutières Syndrome and the Type I Interferonopathies. *Nat. Rev. Immunol.* **2015**, *15*, 429–440. [CrossRef]

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284. Kampmann, B.; Hemingway, C.; Stephens, A.; Davidson, R.; Goodsall, A.; Anderson, S.; Nicol, M.; Schölvinck, E.; Relman, D.; Waddell, S.; et al. Acquired Predisposition to Mycobacterial Disease Due to Autoantibodies to Ifn-Gamma. *J. Clin. Investig.* **2005**, *115*, 2480–2488. [CrossRef] [PubMed]

285. Rong, L.; Perelson, A.S. Treatment of Hepatitis C Virus Infection with Interferon and Small Molecule Direct Antivirals: Viral Kinetics and Modeling. *Crit. Rev. Immunol.* **2010**, *30*, 131–148. [CrossRef] [PubMed]

286. Woo, A.S.J.; Kwok, R.; Ahmed, T. Alpha-Interferon Treatment in Hepatitis B. *Ann. Transl. Med.* **2017**, *5*, 159. [CrossRef] [PubMed]

287. Ghany, M.G.; Morgan, T.R. Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection. *Hepatology* **2020**, *71*, 686–721. [CrossRef]

288. Rodero, M.P.; Crow, Y.J. Type I Interferon—Mediated Monogenic Autoinflammation: The Type I Interferonopathies, a Conceptual Overview. *J. Exp. Med.* **2016**, *213*, 2527–2538. [CrossRef]

289. Crayne, C.B.; Albeituni, S.; Nichols, K.E.; Cron, R.Q. The Immunology of Macrophage Activation Syndrome. *Front. Immunol.* **2019**, *10*. [CrossRef]

290. Limmroth, V.; Putzki, N.; Kachuck, N.J. The Interferon Beta Therapies for Treatment of Relapsing-Remitting Multiple Sclerosis: Are They Equally Efficacious? A Comparative Review of Open-Label Studies Evaluating the Efficacy, Safety, or Dosing of Different Interferon Beta Formulations Alone or in Combination. *Ther. Adv. Neurol. Disord.* **2011**, *4*, 281–296.

291. Malhotra, S.; Río, J.; Urcelay, E.; Nurtdinov, R.; Bustamante, M.F.; Fernández, O.; Oliver, B.; Zettl, U.; Brassat, D.; Killestein, J.; et al. Nlrp3 Inflammasome Is Associated with the Response to Ifn-B in Patients with Multiple Sclerosis. *Brain* **2015**, *138*, 644–652. [CrossRef]

292. Inoue, M.; Williams, K.L.; Oliver, T.; Vandenabeele, P.; Rajan, J.V.; Miao, E.A.; Shinohara, M.L. Interferon-B Therapy against Eae Is Effective Only When Development of the Disease Depends on the Nlrp3 Inflammasome. *Sci. Signal.* **2012**, *5*, ra38. [CrossRef]

293. Weiss, E.S.; Girard-Guyonvarc'h, C.; Holzinger, D.; de Jesus, A.A.; Tariq, Z.; Picarsic, J.; Schiffrin, E.J.; Foell, D.; Grom, A.A.; Ammann, S.; et al. Interleukin-18 Diagnostically Distinguishes and Pathogenically Promotes Human and Murine Macrophage Activation Syndrome. *Blood* **2018**, *131*, 1442–1455. [CrossRef] [PubMed]

294. Zaki, M.H.; Vogel, P.; Malireddi, R.K.; Body-Malapel, M.; Anand, P.K.; Bertin, J.; Green, D.R.; Lamkanfi, M.; Kanneganti, T.D. The Nod-Like Receptor Nlrp12 Attenuates Colon Inflammation and Tumorigenesis. *Cancer Cell* **2011**, *20*, 649–660. [CrossRef] [PubMed]

295. Satie, A.P.; Mazaud-Guittot, S.; Seif, I.; Mahé, D.; He, Z.; Jouve, G.; Jégou, B.; Dejucq-Rainsford, N. Excess Type I Interferon Signaling in the Mouse Seminiferous Tubules Leads to Germ Cell Loss and Sterility. *J. Biol. Chem.* **2011**, *286*, 23280–23295. [CrossRef] [PubMed]

296. Ulusoy, E.; Cayan, S.; Yilmaz, N.; Aktaş, S.; Acar, D.; Doruk, E. Interferon Alpha-2b May Impair Testicular Histology Including Spermatogenesis in a Rat Model. *Arch. Androl.* **2004**, *50*, 379–385. [CrossRef]
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