Samples Detected by Polymerase Chain Reaction. *Int. J. Food Microbiol.* 72 (1-2), 45-52. doi:10.1016/s0168-1605(01)00615-8

Niculescu, A.-G., and Grumezescu, A. M. (2022). Applications of Chitosan-Alginate-Based Nanoparticles-An Up-To-Date Review. *Nanomaterials* 12 (2), 186. doi:10.3390/nano12020186

Nie, H., He, A., Zheng, J., Xu, S., Li, J., and Han, C. C. (2008). Effects of Chain Conformation and Entanglement on the Electrospinning of Pure Alginate. *Biomacromolecules* 9 (5), 1362-1365. doi:10.1021/bm701349j

Nikoo, A. M., Kadkhodaee, R., Ghorani, B., Razzaq, H., and Tucker, N. (2018). Electro spray-assisted Encapsulation of Caffeine in Alginate Microhydrogels. *Int. J. Biol. Macromolecules* 116, 208-216. doi:10.1016/j.ijbiomac.2018.04.167

Nitta, S., and Numata, K. (2013). Biopolymer-based Nanoparticles for Drug/gene Delivery and Tissue Engineering. *IJms* 14 (1), 1629-1654. doi:10.3390/ijms14011629

Nosrati, H., Aramideh Khouy, R., Nosrati, A., Khodaei, M., Banitalebi-Dehkordi, M., Ashrafi-Dehkordi, K., et al. (2021). Nanocomposite Scaffolds for Accelerating Chronic Wound Healing by Enhancing Angiogenesis. *J. Nanobiotechnol* 19 (1), 1. doi:10.1186/s12951-020-00755-7

Olivas, G. I., and Barbosa-Cánovas, G. V. (2008). Alginate-calcium Films: Water Vapor Permeability and Mechanical Properties as Affected by Plasticizer and Relative Humidity. *LWT - Food Sci. Technology* 41 (2), 359-366. doi:10.1016/j.lwt.2007.02.015

Omer, S. (2021). “Heavy Metal Removal by Alginate Based Agriculture and Industrial Waste Nanocomposites,” in *Properties and Applications of Algimates*. Editors I. Deniz, E. Imamoglu, and T. Keskin-Gundogdu (London, UK.: IntechOpen). doi:10.5772/intechopen.98832

Ong, W.-D., Tey, B.-T., Quek, S. Y., Tang, S.-Y., and Chan, E.-S. (2015). Alginate-based Emulsion Template Containing High Oil Loading Stabilized by Nonionic Surfactants. *J. Food Sci.* 80 (1), E93-E100. doi:10.1111/1750-3841.12729

Pakolpakçıl, A., and Draczynski, Z. (2021). Green Approach to Develop Bee Pollen-Loaded Alginate Based Nanofibrous Mat. *Materials* 14 (11), 2775. doi:10.3390/ma14112775

Pan, S.-Y., Litscher, G., Gao, S.-H., Zhou, S.-F., Yu, Z.-L., Chen, H.-Q., et al. (2014). Historical Perspective of Traditional Indigenous Medical Practices: the Current Renaissance and Conservation of Herbal Resources. *Evidence-Based Complement. Altern. Med.* 2014, 1-20. doi:10.1155/2014/525340

Paray, B. A., Kumari, I., Hajam, Y. A., Sharma, B., Kumar, R., Albeshr, M. F., et al. (2021). Honeybee Nutrition and Pollen Substitutes: A Review. *Saudi J. Biol. Sci.* 28 (1), 1167-1176. doi:10.1016/j.sjbs.2020.11.053

Parhi, B., Bharatiya, D., and Swain, S. K. (2020). Application of Quercetin Flavonoid Based Hybrid Nanocomposites: A Review. *Saudi Pharm. J.* 28 (12), 1719-1732. doi:10.1016/j.jsps.2020.10.017

Park, H. M., Hwang, E., Lee, K. G., Han, S.-M., Cho, Y., and Kim, S. Y. (2011). Royal Jelly Protects against Ultraviolet B-Induced Photoaging in Human Skin Fibroblasts Via Enhancing Collagen Production. *J. Med. Food* 14 (9), 899-906. doi:10.1089/jmf.2010.1363

Park, H. S., Kim, S. R., Kim, J. O., and Lee, Y. C. (2010). The Roles of Phytochemicals in Bronchial Asthma. *Molecules* 15 (10), 6810-6834. doi:10.3390/molecules15106810

Parker, R., Melathopoulos, A. P., White, R., Pernal, S. F., Guarna, M. M., and Foster, L. J. (2010). Ecological Adaptation of Diverse Honey Bee (*Apis mellifera*) Populations. *PLoS One* 5 (6), e11096. doi:10.1371/journal.pone.0011096

Partheniadis, I., Nikolakakis, I., Laidmäe, I., and Heinämäki, J. (2020). A Mini-Review: Needleless Electrospinning of Nanofibers for Pharmaceutical and Biomedical Applications. *Processes* 8 (6), 673. doi:10.3390/pr8060673

Pasupuleti, V. R., Sammugam, L., Ramesh, N., and Gan, S. H. (2017). Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. *Oxidative Med. Cell Longevity* 2017, 1-21. doi:10.1155/2017/1259510

Patil, N. H., and Devarajan, P. V. (2016). Insulin-loaded Alginic Acid Nanoparticles for Sublingual Delivery. *Drug Deliv.* 23 (2), 429-436. doi:10.3109/10717544.2016.916769

Patra, J. K., Das, G., Fraceto, L. F., Campos, E. V. R., Rodriguez-Torres, M. d. P., Acosta-Torres, L. S., et al. (2018). Nano Based Drug Delivery Systems: Recent Developments and Future Prospects. *J. Nanobiotechnol* 16 (1), 71. doi:10.1186/s12951-018-0392-8

Pereira, L., and Cotas, J. (2020). “Introductory Chapter: Algimates - A General Overview,” in *Algimates: Recent Uses of This Natural Polymer*. Editor L. Pereira (London, UK: IntechOpen). doi:10.5772/intechopen.88381

Pita-Calvo, C., and Vázquez, M. (2018). Honeydew Honeys: A Review on the Characterization and Authentication of Botanical and Geographical Origins. *J. Agric. Food Chem.* 66 (11), 2523-2537. doi:10.1021/acs.jafc.7b05807

Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., et al. (2017). Oxidative Stress: Harms and Benefits for Human Health. *Oxidative Med. Cell Longevity* 2017, 1-13. doi:10.1155/2017/8416763

Pragya, A., Mutalik, S., Younas, M. W., Pang, S.-K., So, P.-K., Wang, F., et al. (2021). Dynamic Cross-Linking of an Alginate-Acrylamide Tough Hydrogel System: Time-Resolved In Situ Mapping of Gel Self-Assembly. *RSC Adv.* 11 (18), 10710-10726. doi:10.1039/D0RA09210J

Qi, Y., Jiang, M., Cui, Y.-L., Zhao, L., and Zhou, X. (2015). Synthesis of Quercetin Loaded Nanoparticles Based on Alginate for Pb(II) Adsorption in Aqueous Solution. *Nanoscale Res. Lett.* 10 (1), 408. doi:10.1186/s11671-015-1117-7

Rada, S. M. A. (2016). *Healing Activity of Propolis-Alginate Dressing from the Philippine Stingless Bees (Tetragonula Biroi Friese) in a Mouse Model of Excisional Wound*. UNDERGRADUATE THESESES. Los Baños, Philippines: University of the Philippines Los Baños.

Rady, I., Siddiqui, I. A., Rady, M., and Mukhtar, H. (2017). Melittin, a Major Peptide Component of Bee Venom, and its Conjugates in Cancer Therapy. *Cancer Lett.* 402, 16-31. doi:10.1016/j.canlet.2017.05.010

Ranneh, Y., Akim, A. M., Hamid, H. A., Khazaaai, H., Fadel, A., Zakaria, Z. A., et al. (2021). Honey and its Nutritional and Anti-inflammatory Value. *BMC Complement. Med. Ther.* 21 (1), 30. doi:10.1186/s12906-020-03170-5

Rao, P. V., Krishnan, K. T., Salleh, N., and Gan, S. H. (2016). Biological and Therapeutic Effects of Honey Produced by Honey Bees and Stingless Bees: A Comparative Review. *Revista Brasileira de Farmacognosia* 26 (5), 657-664. doi:10.1016/j.bjp.2016.01.012

Rasmussen, C., and Cameron, S. A. (2010). Global Stingless Bee Phylogeny Supports Ancient Divergence, Vicariance, and Long Distance Dispersal. *Biol. J. Linn. Soc.* 99 (1), 206-232. doi:10.1111/j.1095-8312.2009.01341.x

Ravaud, S., Robert, X., Watzlawick, H., Haser, R., Mattes, R., and Aghajari, N. (2007). Trehalulose Synthase Native and Carbohydrate Complexed Structures Provide Insights into Sucrose Isomerization. *J. Biol. Chem.* 282 (38), 28126-28136. doi:10.1074/jbc.M704515200

Reckseidler-Zenteno, S. L. (2012). “Capsular Polysaccharides Produced by the Bacterial Pathogen Burkholderia Pseudomallei,” in *The Complex World of Polysaccharides*. Editor D. N. Karunaratne (London, UK: IntechOpen). doi:10.5772/50116

Resma, C. M. E. (2016). *Evaluation of Propolis-Alginate Dressing Treatment in the Management of Sutured Wound in Cats*. Undergraduate Theses. Los Baños, Philippines: University of the Philippines Los Baños.

Rhein-Knudsen, N., Ale, M., and Meyer, A. (2015). Seaweed Hydrocolloid Production: an Update on Enzyme Assisted Extraction and Modification Technologies. *Mar. Drugs* 13 (6), 3340-3359. doi:10.3390/md13063340

Rhim, J.-W. (2004). Physical and Mechanical Properties of Water Resistant Sodium Alginate Films. *LWT - Food Sci. Technology* 37 (3), 323-330. doi:10.1016/j.lwt.2003.09.008

Rosiak, P., Latanska, I., Paul, P., Sujka, W., and Kolesinska, B. (2021). Modification of Algimates to Modulate Their Physic-Chemical Properties and Obtain Biomaterials with Different Functional Properties. *Molecules* 26 (23), 7264. doi:10.3390/molecules26237264

Saberian, M., Seyedjafari, E., Zargar, S. J., Mahdavi, F. S., and Sanaei-rad, P. (2021). Fabrication and Characterization of Alginate/chitosan Hydrogel Combined with Honey and Aloe Vera for Wound Dressing Applications. *J. Appl. Polym. Sci.* 138 (47), 51398. doi:10.1002/app.51398

Sadek, W., El-Houssiny, A., Al-Mwafy, A., Farag, T., Al-Gethami, A., Grawish, S., et al. (2020). Egyptian Propolis 16: The Effect of Consumption of Propolis and Alginate-Propolis Nanoparticles in Combination with Colostrum on the Performance of Newborn Goats. *Adv. Anim. Vet. Sci.* 8 (12), 1256-1265. doi:10.17582/journal.aavs/2020/8.12.1256.1265

Saeed, M., Abbas Zare, M., Ali, S., Nasser Mohammadpour, d., Saman, S., and Mehrasa Rahimi, B. (2013). Preparation and Characterization of Sodium Alginate Nanoparticles Containing ICD-85 (Venom Derived Peptides). *Int. J. Innovation Appl. Stud.* 4 (3), 534-542.
Saitoh, S., Araki, Y., Kon, R., Katsura, H., and Taira, M. (2000). Swelling/deswelling Mechanism of Calcium Alginate Gel in Aqueous Solutions. *Dental Mater.* J. 19 (4), 396-404. doi:10.4012/dmj.19.396

Salahuddin, H., Shaiqah, M., Afiful Huda, A. A., Izzuddin, M., Nur Shafiq, N. M., Nur Hakimah, M., et al. (2020). Screening of Electro spray-Operating Parameters in the Production of Alginate-Royal Jelly Microbeads Using Factorial Design. *J. Pharm. Bioall Sci.* 12 (Suppl. 2), 703-S706. doi:10.4103/jpbs.JPBS_249_19

Samarghandian, S., Farkhondeh, T., and Samini, F. (2017). Honey and Health: A Review of Recent Clinical Research. *Pharmacognosy Res.* 9 (2), 121-127. doi:10. 4103/0974-8490.204647

Saquing, C. D., Tang, C., Monian, B., Bonino, C. A., Manasco, J. L., Alsberg, E., et al. (2013). Alginate-Polyethylene Oxide Blend Nanofibers and the Role of the Carrier Polymer in Electrospinning. *Ind. Eng. Chem. Res.* 52 (26), 8692-8704. doi:10.1021/ie302385b

Selvaraj, S., Shanmugasundaram, S., Maruthamuthu, M., Venkidasamy, B., and Shanmugasundaram, S. (2021). Facile Synthesis and Characterization of Quercetin-Loaded Alginate Nanoparticles for Enhanced In Vitro Anticancer Effect against Human Leukemic Cancer U937 Cells. *J. Clust Sci.* 32 (6), 1507-1518. doi:10.1007/s10876-020-01913-5

Seo, E.-J., Fischer, N., and Efferth, T. (2018). Phytochemicals as Inhibitors of NF-κB for Treatment of Alzheimer's Disease. *Pharmacol. Res.* 129, 262-273. doi:10. 1016/j.phrs.2017.11.030

Shalumon, K. T., Anulekha, K. H., Nair, S. V., Nair, S. V., Chennazhi, K. P., and Jayakumar, R. (2011). Sodium Alginate/poly(vinyl Alcohol)/nano ZnO Composite Nanofibers for Antibacterial Wound Dressings. *Int. J. Biol. Macromolecules* 49 (3), 247-254. doi:10.1016/j.ijbiomac.2011.04.005

Sharma, D., Kanchi, S., and Bisetty, K. (2019). Biogenic Synthesis of Nanoparticles: A Review. *Arabian J. Chem.* 12 (8), 3576-3600. doi:10.1016/j.arabjc.2015.11.002

Shehata, T. M., and Ibrahima, M. M. (2019). BÜCHI Nano spray Dryer B-90: a Promising Technology for the Production of Metformin Hydrochloride-Loaded Alginate-Gelatin Nanoparticles. *Drug Development Ind. Pharm.* 45 (12), 1907-1914. doi:10.1080/03639045.2019.1680992

Shreyash, N., Bajpai, S., Khan, M. A., Vijay, Y., Tiwary, S. K., and Sonker, M. (2021). Green Synthesis of Nanoparticles and Their Biomedical Applications: A Review. *ACS Appl. Nano Mater.* 4 (11), 11428-11457. doi:10.1021/acsnm. 1c02946

Siavash, M., Shokri, S., Haghighi, S., Shahtalebi, M. A., and Farajzadehgan, Z. (2015). The Efficacy of Topical Royal Jelly on Healing of Diabetic Foot Ulcers: a Double-Blind Placebo-Controlled Clinical Trial. *Int. Wound J.* 12 (2), 137-142. doi:10.1111/iwj.12063

Singh, P., Baisthakur, P., and Yemul, O. S. (2020). Synthesis, Characterization and Application of Crosslinked Alginate as green Packaging Material. *Heliyon* 6 (1), e03026. doi:10.1016/j.heliyon.2019.e03026

Smuga-Kogut, M., Pabiszczak, A., Dymkowska-Malesa, M., Szymanowska, D., Kobus-Cisowska, J., and Cielecka-Piontek, J. (2020). Preparation of Beebread Caviar from Buckwheat Honey through Immobilization with Sodium Alginate. *Molecules* 25 (19), 4483. doi:10.3390/molecules25194483

Song, R., Murphy, M., Li, C., Ting, K., Soo, C., and Zheng, Z. (2018). Current Development of Biodegradable Polymeric Materials for Biomedical Applications. *Dddt* 12, 3117-3145. doi:10.2147/DDDT.S165440

Souad, B., Fatiha, B., Mourad, M., Djamel, A., and Aissa, Z. (2018). Immobilization of the Enzyme Invertase Extracted from the Yeast Saccharomyces Cerevisiae in Calcium Alginate in Order to Improve the Physicochemical Quality of Honey. *J. Adv. Res. Dynamical Control. Syst.* 10 (4), 223-229.

Stalikas, C. D. (2007). Extraction, Separation, and Detection Methods for Phenolic Acids and Flavonoids. *J. Sep. Sci.* 30 (18), 3268-3295. doi:10.1002/jssc. 200700261

Sun, J., and Tan, H. (2013). Alginate-Based Biomaterials for Regenerative Medicine Applications. *Materials* 6 (4), 1285-1309. doi:10.3390/ma6041285

Talebi, M., Talebi, M., Farkhondeh, T., and Samarghandian, S. (2020). Molecular Mechanism-Based Therapeutic Properties of Honey. *Biomed. Pharmacother.* 130, 110590. doi:10.1016/j.biopha.2020.110590

Tang, Y., Lan, X., Liang, C., Zhong, Z., Xie, R., Zhou, Y., et al. (2019). Honey Loaded Alginate/PVA Nanofibrous Membrane as Potential Bioactive Wound Dressing. *Carbohydr. Polym.* 219, 113-120. doi:10.1016/j.carbpol.2019.05.004

Tatli Seven, P., Seven, I., Gul Baykalir, B., Iflazoglu Mutlu, S., and Salem, A. Z. M. (2018). Nanotechnology and Nano-Propolis in Animal Production and Health: an Overview. *Int. J. Anim. Sci.* 17 (4), 921-930. doi:10.1080/1828051X.2018. 1448726

Tati Seven, P., Seven, I., Karakus, S., Iflazoglu Mutlu, S., Arkali, G., Muge Sahin, Y., et al. (2020). Turkish Propolis and its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer. *Plants* 9 (9), 1075. doi:10.3390/plants9091075

Thomas, A., Harding, K. G., and Moore, K. (2000). Alginates from Wound Dressings Activate Human Macrophages to Secrete Tumour Necrosis Factor-α. *Biomaterials* 21 (17), 1797-1802. doi:10.1016/S0142-9612(00) 00072-7

Tsai, S., and Ting, Y. (2019). Synthesize of Alginate/chitosan Bilayer Nanocarrier by CCD-RSM Guided Co-axial Electro spray: A Novel and Versatile Approach. *Food Res. Int.* 116, 1163-1172. doi:10.1016/j foodres.2018.11.047

Ullah, A., Ullah, S., Khan, M. Q., Hashmi, M., Nam, P. D., Kato, Y., et al. (2020). Manuka Honey Incorporated Cellulose Acetate Nanofibrous Mats: Fabrication and In Vitro Evaluation as a Potential Wound Dressing. *Int. J. Biol. Macromolecules* 155, 479-489. doi:10.1016/j.ijbiomac.2020.03.237

van der Weyden, E. A. (2005). Treatment of a Venous Leg Ulcer with a Honey Alginate Dressing. *Br. J. Community Nurs.* 10 (S24), S21-S27. doi:10.12968/ bjcn.2005.10.sup2.18175

Velasco-Barraza, R. D., Vera-Graziano, R., López-Maldonado, E. A., Oropeza-Guzmán, M. T., Dastager, S. G., Álvarez-Andrade, A., et al. (2018). Study of Nanofiber Scaffolds of PAA, PAA/CS, and PAA/ALG for its Potential Use in Biotechnological Applications. *Int. J. Polymeric Mater. Polymeric Biomater.* 67 (13), 800-807. doi:10.1080/00914037.2017.1378887

Velmurugan, R., Selvamuthukumar, S., and Manavalan, R. (2011). Multi Criteria Decision Making to Select the Suitable Method for the Preparation of Nanoparticles Using an Analytical Hierarchy Process. *Pharmazie* 66 (11), 836-842.

Virtucio, R. C. P. (2014). *Healing Activity of Gamma Radiated Honey-Alginate and Propolis-Alginate Dressings from the Philippine Stingless Bees (Tetragona Biroi) on a Mouse Model of Incisional Wound*. Undergraduate Theses. Los Baños, Philippines: University of the Philippines Los Baños.

Vit, P., Pedro, S. R., and Roubik, D. (2013). *Pot-honey: A Legacy of Stingless Bees*. New York: Springer Science & Business Media.

Wang, W., Lu, K.-j., Yu, C.-h., Huang, Q.-l., and Du, Y.-Z. (2019). Nano-drug Delivery Systems in Wound Treatment and Skin Regeneration. *J. Nanobiotechnol* 17 (1), 82. doi:10.1186/s12951-019-0514-y

Wang, X., Xie, H., Shi, C., Dziugan, P., Zhao, H., and Zhang, B. (2021). Fabrication and Characterization of Gel Beads of Whey Isolate Protein-Pectin Complex for Loading Quercetin and Their Digestion Release. *Gels* 8 (1), 18. doi:10.3390/ gels8010018

Wattanakul, K., Imae, T., Chang, W.-W., Chu, C.-C., Nakahata, R., and Yusa, S.-i. (20192019). Oligopeptide-side Chained Alginate Nanocarrier for Melittin-Targeted Chemotherapy. *Polym. J.* 51, 771-780. doi:10.1038/s41428-019- 0191-6

Webb, M. K. (2009). Management of an Mrsa Colonized Wound Using Leptospermum Honey—Impregnated Calcium Alginate Dressings. *J. Wound Ostomyx Continence Nurs.* S17.

Wehbe, R., Frangieh, J., Rima, M., El Obeid, D., Sabatier, J.-M., and Fajloun, Z. (2019). Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests. *Molecules* 24 (16), 2997. doi:10.3390/molecules24162997

White, J. W. (1978). Honey. *Adv. Food Res.* 24, 287-374. doi:10.1016/s0065- 2628(08)60160-3

Wright, G. A., Nicolson, S. W., and Shafir, S. (2018). Nutritional Physiology and Ecology of Honey Bees. *Annu. Rev. Entomol.* 63, 327-344. doi:10.1146/ annurev-ent-020117-043423

Xing, L., Dawei, C., Liping, X., and Rongqing, Z. (2003). Oral colon-specific Drug Delivery for Bee Venom Peptide: Development of a Coated Calcium Alginate Gel Beads-Entrapped Liposome. *J. Controlled Release* 93 (3), 293-300. doi:10. 1016/j.jconrel.2003.08.019

Xue, J., Wu, T., Dai, Y., and Xia, Y. (2019). Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications. *Chem. Rev.* 119 (8), 5298-5415. doi:10.1021/acs.chemrev.8b00593

Yadav, S., Asthana, A., Chakraborty, R., Jain, B., Singh, A. K., Carabineiro, S. A. C., et al. (2020). Cationic Dye Removal Using Novel Magnetic/Activated Charcoal/ β-Cyclodextrin/Alginate Polymer Nanocomposite. *Nanomaterials* 10 (1), 170. doi:10.3390/nano1001070
Yang, D., and Jones, K. S. (2009). Effect of Alginate on Innate Immune Activation of Macrophages. *J. Biomed. Mater. Res.* 90A (2), 411–418. doi:10.1002/jbm.a.32096

Yesiltas, B., Capanoglu, E., Firatligil-Durmus, E., Sunay, A. E., Samanci, T., and Boyacioglu, D. (2014). Investigating the In-Vitro Bioaccessibility of Propolis and Pollen Using a Simulated Gastrointestinal Digestion System. *J. Apicultural Res.* 53 (1), 101–108. doi:10.3896/IBRA.1.53.1.10

Yom-Tov, O., Seliktar, D., and Bianco-Peled, H. (2015). A Modified Emulsion Gelation Technique to Improve Buoyancy of Hydrogel Tablets for Floating Drug Delivery Systems. *Mater. Sci. Eng.* C 55, 335–342. doi:10.1016/j.msec.2015.05.057

Zawawi, N., Zhang, J., Hungerford, N. L., Yates, H. S. A., Webber, D. C., Farrell, M., et al. (2022). Unique Physicochemical Properties and Rare Reducing Sugar Trehalulose Mandate New International Regulation for Stingless Bee Honey. *Food Chem.* 373 (B), 131566. doi:10.1016/j.foodchem.2021.131566

Zhang, C., Grossier, R., Candoni, N., and Veesler, S. (2021a). Preparation of Alginate Hydrogel Microparticles by Gelation Introducing Cross-Linkers Using Droplet-Based Microfluidics: a Review of Methods. *Biomater. Res.* 25 (1), 41. doi:10.1186/s40824-021-00243-5

Zhang, H., Cheng, J., and Ao, Q. (2021b). Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine. *Mar. Drugs* 19 (5), 264. doi:10.3390/md19050264

Zhang, H., Fu, Y., Xu, Y., Niu, F., Li, Z., Ba, C., et al. (2019). One-step Assembly of Zein/caseinate/alginate Nanoparticles for Encapsulation and Improved Bioaccessibility of Propolis. *Food Funct.* 10 (2), 635–645. doi:10.1039/C8FO01614C

Zhang, Z., and Zhang, X. (2021). Curcumin Loading on Alginate Nano-Micelle for Anti-infection and Colonic Wound Healing. *J Biomed. Nanotechnol* 17 (6), 1160–1169. doi:10.1166/jbn.2021.3089

Zhao, R., Liang, H., Clarke, E., Jackson, C., and Xue, M. (2016). Inflammation in Chronic Wounds. *Ijms* 17 (12), 2085. doi:10.3390/ijms17122085

Zhu, J., and Marchant, R. E. (2011). Design Properties of Hydrogel Tissue-Engineering Scaffolds. *Expert Rev. Med. Devices* 8 (5), 607–626. doi:10.1586/erd.11.27

Zhuang, Y., Yu, F., Chen, J., and Ma, J. (2016). Batch and Column Adsorption of Methylene Blue by Graphene/alginate Nanocomposite: Comparison of Single-Network and Double-Network Hydrogels. *J. Environ. Chem. Eng.* 4 (1), 147–156. doi:10.1016/j.jece.2015.11.014

Zulkhairi Amin, F. A., Sabri, S., Mohammad, S. M., Ismail, M., Chan, K. W., Ismail, N., et al. (2018). Therapeutic Properties of Stingless Bee Honey in Comparison with European Bee Honey. *Adv. Pharmacol. Sci.* 2018, 1–12. doi:10.1155/2018/6179596

**Conflict of Interest:** Author VU is the cofounder of TardigradeNano LLC, a biotech startup with no commercial or financial interest in the topic elaborated here.

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

**Publisher's Note:** All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Copyright © 2022 Al-Hatamleh, Alshaer, Hatmal, Lambuk, Ahmed, Mustafa, Low, Jaafar, Ferji, Six, Uskoković and Mohamud. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.