# UHRF1 wt Allele

National Cancer Institute

## Source

National Cancer Institute. <u>UHRF1 wt Allele</u>, NCI Thesaurus. Code C115278.

Human UHRF1 wild-type allele is located in the vicinity of 19p13.3 and is approximately 59 kb in length. This allele, which encodes E3 ubiquitin-protein ligase UHRF1 protein, plays a role in both protein ubiquitination and epigenetic silencing of gene transcription. Aberrant expression of the gene is associated with many neoplastic diseases.