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167. Sun, C.; Li, G.; Li, H.; Lyu, Y.; Yu, S.; Zhou, J. Enhancing Flavan-3-ol Biosynthesis in *Saccharomyces cerevisiae*. *J. Agric. Food Chem.* **2021**, *69*, 12763-12772. [CrossRef]

168. Liu, S.; Lyu, Y.; Yu, S.; Cheng, J.; Zhou, J. Efficient production of orientin and vitexin from luteolin and apigenin using coupled catalysis of glycosyltransferase and sucrose synthase. *J. Agric. Food Chem.* **2021**, *69*, 6578-6587. [CrossRef]

169. Liu, Y.; Xu, Y.; Ding, D.; Wen, J.; Zhu, B.; Zhang, D. Genetic engineering of *Escherichia coli* to improve L-phenylalanine production. *BMC Biotechnol.* **2018**, *18*, 5. [CrossRef]

170. Jiang, M.; Zhang, H. Engineering the shikimate pathway for biosynthesis of molecules with pharmaceutical activities in *E. coli*. *Curr. Opin. Biotechnol.* **2016**, *42*, 1-6. [CrossRef]

171. Fordjour, E.; Adipah, F.K.; Zhou, S.; Du, G.; Zhou, J. Metabolic engineering of *Escherichia coli* BL21 (DE3) for de novo production of L-DOPA from D-glucose. *Microb. Cell Factories* **2019**, *18*, 74. [CrossRef]

172. Li, S.; Zhang, Q.; Wang, J.; Liu, Y.; Zhao, Y.; Deng, Y. Recent progress in metabolic engineering of *Saccharomyces cerevisiae* for the production of malonyl-CoA derivatives. *J. Biotechnol.* **2021**, *325*, 83-90. [CrossRef] [PubMed]

173. Zhou, S.; Yuan, S.-F.; Nair, P.H.; Alper, H.S.; Deng, Y.; Zhou, J. Development of a growth coupled and multi-layered dynamic regulation network balancing malonyl-CoA node to enhance (2S)-naringenin biosynthesis in *Escherichia coli*. *Metab. Eng.* **2021**, *67*, 41-52. [CrossRef] [PubMed]

174. Li, S.; Fu, W.; Su, R.; Zhao, Y.; Deng, Y. Metabolic engineering of the malonyl-CoA pathway to efficiently produce malonate in *Saccharomyces cerevisiae*. *Metab. Eng.* **2022**, *73*, 1-10. [CrossRef]

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177. Zhou, S.; Lyu, Y.; Li, H.; Koffas, M.A.; Zhou, J. Fine-tuning the (2S)-naringenin synthetic pathway using an iterative high-throughput balancing strategy. *Biotechnol. Bioeng.* **2019**, *116*, 1392–1404. [CrossRef] [PubMed]

178. Pei, J.; Sun, Q.; Gu, N.; Zhao, L.; Fang, X.; Tang, F.; Cao, F. Production of isoorientin and isovitexin from luteolin and apigenin using coupled catalysis of glycosyltransferase and sucrose synthase. *Appl. Biochem. Biotechnol.* **2020**, *190*, 601–615. [CrossRef]

179. Eichenberger, M.; Hansson, A.; Fischer, D.; Dürr, L.; Naesby, M. De novo biosynthesis of anthocyanins in *Saccharomyces cerevisiae*. *FEMS Yeast Res.* **2018**, *18*, foy046. [CrossRef]

180. Wang, P.; Li, C.; Li, X.; Huang, W.; Wang, Y.; Wang, J.; Zhang, Y.; Yang, X.; Yan, X.; Wang, Y. Complete biosynthesis of the potential medicine icaritin by engineered *Saccharomyces cerevisiae* and *Escherichia coli*. *Sci. Bull.* **2021**, *66*, 1906–1916. [CrossRef]

181. Yang, J.; Liang, J.; Shao, L.; Liu, L.; Gao, K.; Zhang, J.-L.; Sun, Z.; Xu, W.; Lin, P.; Yu, R. Green production of silybin and isosilybin by merging metabolic engineering approaches and enzymatic catalysis. *Metab. Eng.* **2020**, *59*, 44–52. [CrossRef]

182. Wang, X.; Li, Z.; Policarpio, L.; Koffas, M.A.G.; Zhang, H. De novo biosynthesis of complex natural product sakuranetin using modular co-culture engineering. *Appl. Microbiol. Biotechnol.* **2020**, *104*, 4849–4861. [CrossRef]

183. Thuan, N.H.; Chaudhary, A.K.; Van Cuong, D.; Cuong, N.X. Engineering co-culture system for production of apigetrin in *Escherichia coli*. *J. Ind. Microbiol. Biotechnol.* **2018**, *45*, 175–185. [CrossRef] [PubMed]

184. Wu, G.; Yan, Q.; Jones, J.A.; Tang, Y.J.; Fong, S.S.; Koffas, M.A.G. Metabolic Burden: Cornerstones in Synthetic Biology and Metabolic Engineering Applications. *Trends Biotechnol.* **2016**, *34*, 652–664. [CrossRef] [PubMed]

185. Akdemir, H.; Silva, A.; Zha, J.; Zagorevski, D.V.; Koffas, M.A.G. Production of pyranoanthocyanins using *Escherichia coli* co-cultures. *Metab. Eng.* **2019**, *55*, 290–298. [CrossRef] [PubMed]

186. Thuan, N.H.; Tatipamula, V.B.; Viet, T.T.; Tien, N.Q.D.; Loc, N.H. Bioproduction of eriodictyol by *Escherichia coli* engineered co-culture. *World J. Microbiol. Biotechnol.* **2022**, *38*, 112. [CrossRef]

187. Qiu, C.; Wang, H.; Zhao, L.; Pei, J. Orientin and vitexin production by a one-pot enzymatic cascade of a glycosyltransferase and sucrose synthase. *Bioorg. Chem.* **2021**, *112*, 104926. [CrossRef]

188. Zhang, W.; Liu, H.; Li, X.; Liu, D.; Dong, X.T.; Li, F.F.; Wang, E.X.; Li, B.Z.; Yuan, Y.J. Production of naringenin from D-xylose with co-culture of *E. coli* and *S. cerevisiae*. *Eng. Life Sci.* **2017**, *17*, 1021–1029. [CrossRef]

189. Lu, Y.; Song, Y.; Zhu, J.; Xu, X.; Pang, B.; Jin, H.; Jiang, C.; Liu, Y.; Shi, J. Potential application of CHS and 4CL genes from grape endophytic fungus in production of naringenin and resveratrol and the improvement of polyphenol profiles and flavour of wine. *Food Chem.* **2021**, *347*, 128972. [CrossRef]

**Disclaimer/Publisher's Note:** The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.
176. Ramzi, A.B. Metabolic Engineering and Synthetic Biology. In *Omics Applications for Systems Biology*; Aizat, W.M., Goh, H.-H., Baharum, S.N., Eds.; Springer International Publishing: Cham, Switzerland, 2018; pp. 81–95.

177. Zhou, S.; Lyu, Y.; Li, H.; Koffas, M.A.; Zhou, J. Fine-tuning the (2S)-naringenin synthetic pathway using an iterative high-throughput balancing strategy. *Biotechnol. Bioeng.* **2019**, *116*, 1392–1404. [CrossRef] [PubMed]

178. Pei, J.; Sun, Q.; Gu, N.; Zhao, L.; Fang, X.; Tang, F.; Cao, F. Production of isoorientin and isovitexin from luteolin and apigenin using coupled catalysis of glycosyltransferase and sucrose synthase. *Appl. Biochem. Biotechnol.* **2020**, *190*, 601–615. [CrossRef]

179. Eichenberger, M.; Hansson, A.; Fischer, D.; Dürr, L.; Naesby, M. De novo biosynthesis of anthocyanins in *Saccharomyces cerevisiae*. *FEMS Yeast Res.* **2018**, *18*, foy046. [CrossRef]

180. Wang, P.; Li, C.; Li, X.; Huang, W.; Wang, Y.; Wang, J.; Zhang, Y.; Yang, X.; Yan, X.; Wang, Y. Complete biosynthesis of the potential medicine icaritin by engineered *Saccharomyces cerevisiae* and *Escherichia coli*. *Sci. Bull.* **2021**, *66*, 1906–1916. [CrossRef]

181. Yang, J.; Liang, J.; Shao, L.; Liu, L.; Gao, K.; Zhang, J.-L.; Sun, Z.; Xu, W.; Lin, P.; Yu, R. Green production of silybin and isosilybin by merging metabolic engineering approaches and enzymatic catalysis. *Metab. Eng.* **2020**, *59*, 44–52. [CrossRef]

182. Wang, X.; Li, Z.; Policarpio, L.; Koffas, M.A.G.; Zhang, H. De novo biosynthesis of complex natural product sakuranetin using modular co-culture engineering. *Appl. Microbiol. Biotechnol.* **2020**, *104*, 4849–4861. [CrossRef]

183. Thuan, N.H.; Chaudhary, A.K.; Van Cuong, D.; Cuong, N.X. Engineering co-culture system for production of apigetrin in *Escherichia coli*. *J. Ind. Microbiol. Biotechnol.* **2018**, *45*, 175–185. [CrossRef] [PubMed]

184. Wu, G.; Yan, Q.; Jones, J.A.; Tang, Y.J.; Fong, S.S.; Koffas, M.A.G. Metabolic Burden: Cornerstones in Synthetic Biology and Metabolic Engineering Applications. *Trends Biotechnol.* **2016**, *34*, 652–664. [CrossRef] [PubMed]

185. Akdemir, H.; Silva, A.; Zha, J.; Zagorevski, D.V.; Koffas, M.A.G. Production of pyranoanthocyanins using *Escherichia coli* co-cultures. *Metab. Eng.* **2019**, *55*, 290–298. [CrossRef] [PubMed]

186. Thuan, N.H.; Tatipamula, V.B.; Viet, T.T.; Tien, N.Q.D.; Loc, N.H. Bioproduction of eriodictyol by *Escherichia coli* engineered co-culture. *World J. Microbiol. Biotechnol.* **2022**, *38*, 112. [CrossRef]

187. Qiu, C.; Wang, H.; Zhao, L.; Pei, J. Orientin and vitexin production by a one-pot enzymatic cascade of a glycosyltransferase and sucrose synthase. *Bioorg. Chem.* **2021**, *112*, 104926. [CrossRef]

188. Zhang, W.; Liu, H.; Li, X.; Liu, D.; Dong, X.T.; Li, F.F.; Wang, E.X.; Li, B.Z.; Yuan, Y.J. Production of naringenin from D-xylose with co-culture of *E. coli* and *S. cerevisiae*. *Eng. Life Sci.* **2017**, *17*, 1021–1029. [CrossRef]

189. Lu, Y.; Song, Y.; Zhu, J.; Xu, X.; Pang, B.; Jin, H.; Jiang, C.; Liu, Y.; Shi, J. Potential application of CHS and 4CL genes from grape endophytic fungus in production of naringenin and resveratrol and the improvement of polyphenol profiles and flavour of wine. *Food Chem.* **2021**, *347*, 128972. [CrossRef]

**Disclaimer/Publisher's Note:** The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.