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							Issue
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<div>
											BIO Web Conf.
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<div><strong>Volume </strong>209, 2026				</div>
				
					                The 1<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> International Conference on Biological Technology and Engineering for Sustainable Nature (IC-BioTEStA 2025)
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					Article Number
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<td>03003</td>
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					Number of page(s)
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<td>8</td>
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<th>Section</th>
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<td>Biomedical and Pharmaceutical Sciences</td>
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<th>DOI</th>
<td></td>
<td>
<a href="https://doi.org/10.1051/bioconf/202620903003">
					https://doi.org/10.1051/bioconf/202620903003
				</a>
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<th>Published online</th>
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				09 January 2026
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## The Effects of Scurrula atropurpurea and Dendrophthoe pentandra Leaves on Platelet and Leukocyte Profiles: A Phase 1 Clinical Trial

Hajid Iqbal Prasetyo1, Silvy Amalia Falyani1,2, Nour Athiroh Abdoes Sjakoer3 and Erna Sulistyowati1,21

1 Department of Medicine, Faculty of Medicine, Universitas Islam Malang, Malang, Indonesia 2 Center for the Integration of Islamic Medicine, Bioinformatics, and Indonesian Traditional Medicine, Universitas Islam Malang, Malang, Indonesia 3 Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Islam Malang, Malang, Indonesia

1 Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Tea mistletoe (Scurrula atropurpurea) and mango mistletoe (Dendrophthoe pentandra) (SADP) are parasitic plants that are widely utilized as folk medicines due to the presence of some active flavonoid compounds. However, there are no scientific reports regarding the effects of SADP on platelet and leukocyte profiles in humans. Therefore, we studied the impact of SADP on healthy human subjects. This single-blinded clinical trial involved 15 days of oral administration of SADP capsules and enrolled 28 residents of Malang. They were then divided into two groups: a placebo group (n=13) and a treatment group (n=15). The treatment group received 560 mg of S. atropurpurea and 187 mg of the D. pentandra leaves powder. After 15 days, subjects were measured for platelet, leukocyte counts, platelet distribution width (PDW), and leukocyte differential count. Our findings showed no significant differences between the placebo and treatment groups in platelet and leukocyte counts, PDW, or leukocyte differential counts. It can be concluded that SADP administered orally for 15 days was safe in healthy human subjects.

Key words: Scurrula atropurpurea BI. Dans / Dendrophthoe petandra / platelet profile / leukocyte profile / first phase of clinical trial

© The Authors, published by EDP Sciences, 2026

This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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