<figure><img src="image_1.png" /></figure>

# Author Correction: Integrative genetic analysis illuminates ALS heritability and identifies risk genes

Correction to: *Nature Communications*
https://doi.org/10.1038/s41467-022-35724-1,
published online 20 January 2023

https://doi.org/10.1038/s41467-023-43710-4

Published online: 04 December 2023

<figure><img src="image_2.png" /></figure>

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Salim Megat, Natalia Mora, Jason Sanogo, Olga Roman, Alberto Catanese, Najwa Ouali Alami, Axel Freischmidt, Xhuljana Mingaj, Hortense De Calbiac, François Muratet, Sylvie Dirrig-Grosch, Stéphane Dieterle, Nick Van Bakel, Kathrin Müller, Kirsten Sieverding, Jochen Weishaupt, Peter Munch Andersen, Markus Weber, Christoph Neuwirth, Markus Margelisch, Andreas Sommacal, Kristel R. Van Eijk, Jan H. Veldink, Project Mine Als Sequencing Consortium*, Géraldine Lautrette, Philippe Couratier, Agnès Camuzat, Isabelle Le Ber, Maurizio Grassano, Adriano Chio, Tobias Boeckers, Albert C. Ludolph, Francesco Roselli, Deniz Yilmazer-Hanke, Stéphanie Millecamps, Edor Kabashi, Erik Storkebaum, Chantal Sellier & Luc Dupuis

The original version of this article contained errors in Table 2 in the variant_location, cDNA_change, protein_change and dbSNPid columns. The correct version of Table 2 is:

<table><thead><tr><th>variant_type</th><th>variant_location</th><th>cDNA_change</th><th>protein_change</th><th>gnomAD_AF</th><th>ALS cases (n = 9390)</th><th>Control (n = 4594)</th><th>MVP</th><th>CADD</th><th>dbSNPid</th></tr></thead><tbody><tr><td>missenseief variant</td><td>22:g.45564104G>A</td><td>c.46G>A</td><td>p.Asp16Asn</td><td>0.000322851</td><td>11</td><td>2</td><td>0.87</td><td>26.5</td><td>rs200329756</td></tr><tr><td>frameshift variant</td><td>22:g.45564091dupATAGGAATTG</td><td>c.35_45dupATAGGAATTGG</td><td>p.Asp16fs</td><td>NA</td><td>1</td><td>0</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>structural</td><td>22:g.45564117A>G</td><td>c.59A>G</td><td>p.Glu20Gly</td><td>4.2e-06</td><td>3</td><td>0</td><td>0.84</td><td>26.3</td><td>rs1200142847</td></tr><tr><td>structural</td><td>22:g.45567544C>T</td><td>c.133C>T</td><td>p.Arg45Cys</td><td>9.68367e-05</td><td>9</td><td>0</td><td>0.89</td><td>28.1</td><td>rs113634721</td></tr><tr><td>missense variant</td><td>22:g.45571835C>T</td><td>c.214C>T</td><td>p.Arg72Cys</td><td>3.23018e-05</td><td>1</td><td>0</td><td>0.81</td><td>23.6</td><td>rs781273344</td></tr><tr><td>splice variant</td><td>22:g.45574119G>A</td><td>c.341G>A</td><td>p.Gly114Asp</td><td>0.000419897</td><td>3</td><td>0</td><td>0.73</td><td>24.2</td><td>rs148003438</td></tr><tr><td>missense variant</td><td>22:g.45574245A>G</td><td>c.467A>G</td><td>p.Tyr156Cys</td><td>2.88367e-05</td><td>1</td><td>0</td><td>0.75</td><td>23</td><td>rs779406443</td></tr><tr><td>missense variant</td><td>22:g.45574601A>G</td><td>c.823A>G</td><td>p.Lys275Glu</td><td>3.22768e-05</td><td>2</td><td>0</td><td>0.71</td><td>23.5</td><td>rs753113949</td></tr><tr><td>splice acceptor</td><td>22:g.45567480G>C</td><td>c.70_1G>C</td><td>NA</td><td>3.9e-06</td><td>1</td><td>0</td><td>NA</td><td>32</td><td>rs770658454</td></tr><tr><td>missense variant</td><td>22:g.45574313C>G</td><td>c.535C>G</td><td>p.Pro179Ala</td><td>6.52768e-06</td><td>1</td><td>0</td><td>0.81</td><td>22.4</td><td>rs763689432</td></tr><tr><td>missense variant</td><td>22:g.45580471C>T</td><td>c.1342C>T</td><td>p.Arg448Trp</td><td>6.52768e-05</td><td>1</td><td>0</td><td>0.91</td><td>24</td><td>rs777952476</td></tr></tbody></table>

which replaces the previous incorrect version:

<table><thead><tr><th>variant_type</th><th>variant_location</th><th>cDNA_change</th><th>protein_change</th><th>gnomAD_AF</th><th>ALS cases (n = 9390)</th><th>Control (n = 4594)</th><th>MVP</th><th>CADD</th><th>dbSNPid</th></tr></thead><tbody><tr><td>missense variant</td><td>22:g.45564104G>A</td><td>c.46G>A</td><td>p.Asp16Asn</td><td>0.000322851</td><td>11</td><td>2</td><td>0.88</td><td>26.5</td><td>rs200329756</td></tr><tr><td>frameshift variant</td><td>22:g.45564091dupATAGGAATTG</td><td>c.35_45dupATAGGAATTGG</td><td>p.Asp16fs</td><td>NA</td><td>1</td><td>0</td><td>NA</td><td>NA</td><td>NA</td></tr><tr><td>structural</td><td>22:g.45564117A>G</td><td>c.59A>G</td><td>p.Gln20Cys</td><td>4.2e-06</td><td>3</td><td>0</td><td>0.86</td><td>26.3</td><td>rs1200142847</td></tr><tr><td>structural</td><td>22:g.45567544C>T</td><td>c.133C>T</td><td>p.Arg45Cys</td><td>9.68367e-05</td><td>9</td><td>0</td><td>0.89</td><td>28.1</td><td>rs113634721</td></tr><tr><td>missense variant</td><td>22:g.45571835C>T</td><td>c.214C>T</td><td>p.Arg72Cys</td><td>3.23018e-05</td><td>1</td><td>0</td><td>0.81</td><td>23.6</td><td>rs781273344</td></tr><tr><td>splice variant</td><td>22:g.45574119G>A</td><td>c.341G>A</td><td>p.Gly114Asp</td><td>0.000419897</td><td>3</td><td>0</td><td>0.74</td><td>24.2</td><td>rs148003438</td></tr><tr><td>missense variant</td><td>22:g.45574245A>G</td><td>c.467A>G</td><td>p.Tyr156Cys</td><td>2.88367e-05</td><td>1</td><td>0</td><td>0.76</td><td>23</td><td>rs779406443</td></tr><tr><td>missense variant</td><td>22:g.45574601A>G</td><td>c.823A>G</td><td>p.Lys275Glu</td><td>3.22768e-05</td><td>2</td><td>0</td><td>0.71</td><td>23.5</td><td>rs753113943</td></tr><tr><td>splice acceptor</td><td>22:g.45567480G>C</td><td>c.70_1G>C</td><td>NA</td><td>3.9e-06</td><td>1</td><td>0</td><td>NA</td><td>32</td><td>rs770658454</td></tr><tr><td>missense variant</td><td>22:g.45178432C>G</td><td>c.734C>G</td><td>p.Pro179Ala</td><td>6.52768e-06</td><td>1</td><td>0</td><td>0.81</td><td>22.4</td><td>rs763689432</td></tr><tr><td>missense variant</td><td>22:g.45184590C>T</td><td>c.1734C>G</td><td>p.Arg448Trp</td><td>6.52768e-05</td><td>1</td><td>0</td><td>0.91</td><td>24</td><td>rs777952476</td></tr></tbody></table>

In addition, the original version of Fig. 3c showed one variant (Lys275Glu) in an incorrect location and another variant (Arg448Trp) was missing. The correct version of Fig. 3 is:

<footnote>*A list of authors and their affiliations appears online.</footnote>
a

Rare damaging variant burden analysis
(2,794 ALS/FTD cases and 2,010 controls)

<figure><img src="image_3.png" /></figure>

b

<figure><img src="image_4.png" /></figure>

Replication (6,596 ALS cases and 2,584 controls)
Discovery (2,794 ALS/FTD cases and 2,010 controls)
Inverse variance-weighted meta-analysis

c

NUP50 variants

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d

Patient 1: p.Phe58fs

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e

Patient 1: p.Phe58fs

<figure><img src="image_7.png" /></figure>

f

RT-qPCR, lymphoblasts

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which replaces the previous incorrect version:
a
Rare damaging variant burden analysis
(2,794 ALS/FTD cases and 2,010 controls)

<figure><img src="image_9.png" /></figure>

<figure><img src="image_10.png" /></figure>

Replication (6,596 ALS cases and 2,584 controls)
Discovery (2,794 ALS/FTD cases and 2,010 controls)
Inverse variance-weighted meta-analysis

This has been corrected in both the PDF and HTML versions of the
Article.

c
NUP50 variants

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d
Patient 1: p.Phe58fs

<figure><img src="image_12.png" /></figure>

e
Patient 1: p.Phe58fs

<figure><img src="image_13.png" /></figure>

f
RT-qPCR, lymphoblasts

<figure><img src="image_14.png" /></figure>

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