# Selective Aerobic Oxidation of Benzyl Alcohols with Palladium(0) Nanoparticles Suspension in Water

D. Bourbiaux, S. Mangematin, L. Djakovitch, F. Rataboul

► To cite this version:

D. Bourbiaux, S. Mangematin, L. Djakovitch, F. Rataboul. Selective Aerobic Oxidation of Benzyl Alcohols with Palladium(0) Nanoparticles Suspension in Water. Catalysis Letters, In press, 10.1007/s10562-021-03581-0. hal-03182207

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# Selective Aerobic Oxidation of Benzyl Alcohols with Palladium(0) Nanoparticles Suspension in Water

Dolorès Bourbiaux<fnref n="1" /> · Stéphane Mangematin<fnref n="1" /> · Laurent Djakovitch<fnref n="1" /> · Franck Rataboul<fnref n="1" />

## Abstract

This study concerns one of the rare applications of a suspension of palladium nanoparticles in water for oxidation reactions. The aqueous suspension containing well dispersed nanoparticles of 3.85 nm was obtained following a straightforward procedure involving the reduction of $Na_2PdCl_4$ with $NaBH_4$ in the presence of PVP as stabilizing agent. In the way of oxidative catalytic valorisation of lignin, the aqueous suspension was directly applied as catalytic medium for the selective oxidation of vanillic alcohol into vanillin (80 °C, $O_2$, 1 h) with more than 90% yield. Reusability of the catalytic medium has been demonstrated, acting as “quasi-homogeneous catalyst”. More sophisticated lignin-derived substrates like veratryl alcohol and hydrobenzoin gave yields of 50–80% to the respective aldehyde and ketone. In parallel, this as-synthesized suspension was directly used to prepare a $Pd/TiO_2$ catalyst, the latter showing less efficiency for the catalytic transformations.

## Graphic Abstract

<figure><img src="image_2.png" /></figure>

**Keywords** Metallic nanoparticles · Catalysis · Alcohols oxidation · Aqueous suspension

## 1 Introduction

The catalytic oxidation of alcohols is an important reaction giving aldehydes, ketones and carboxylic acids as valuable compounds for the chemical industry. Molecular catalysts and organic media are often used for this transformation. Besides, metal nanoparticles (NPs), particularly deposited on a support, are of great potential for oxidation reactions

[1, 2] and Pd is one of the most interesting metals [3–5]. Such heterogeneous catalysts are particularly powerful to conduct oxidations in environmentally friendly conditions, i.e. in water using oxygen or air as oxidant, especially if water is the solvent to implement both catalyst preparations and catalytic reactions.

Considering this general context of sustainable chemistry the oxidation of biosourced substrates like lignin is of great potential for the production of molecules of interest. Indeed lignin is a direct renewable source of aromatics and in recent years many studies reported its catalytic valorization under oxidative atmosphere giving oxygenated aromatics [6–8]. The oxidative transformation of lignin

<footnote>☒ Franck Rataboul
franck.rataboul@ircelyon.univ-lyon1.fr</footnote>

<footnote n="1">¹ Univ Lyon, Université Claude Bernard Lyon 1, CNRS, IRCELYON, 69626 Villeurbanne, France</footnote>
generally leads to vanillin and related products through
the oxidative cleavage of benzylic functions present in the
substrate structure [9, 10].

More generally, recent examples reported the aerobic
oxidation of benzyl alcohols in water using Pd-based het-
erogeneous catalysts. For instance Pd(0) nanoparticles
supported on a polymer have been directly prepared by the
polymerization of the Pd-containing methacrylate mono-
mer giving selective formation of aldehydes or ketones
[11]. More recently bimetallic Au-Pd NPs supported on
alumina showed higher activity than the monometallic NPs
for the selective oxidation of various benzyl alcohol deriv-
atives [12]. Pd(0) NPs deposited on mesoporous carbon
nanocomposites correspond to a rare example of catalyst
oxidizing benzyl alcohols to the corresponding carboxy-
lic acids [13]. Beside these supported-metal catalysts, a
recent approach based on metal suspensions in a solvent
gives dispersed (colloidal) nanoparticles having catalytic
behaviour often considered as "quasi-homogeneous"
[14–17]. If water is used as solvent, a stabilizer soluble in
water is required and several systems have been reported
to date especially for noble metals [18]. In the case of
Pd aqueous suspensions, Pd chloride salts are often used
as precursors in the presence of water soluble stabilizers
like polymers (polyvinyl alcohol, polyvinyl pyrrolidone,
polyethylene diamine, polystyrene, polyethylene glycol)
[19–23], short- and long-chain surfactants [24, 25], calix-
arenes, cyclodextrins [26, 27], natural ligand (glucose,
starch, proteins) [28–30] and P- or P–O-based ligands [31,
32]. As for heterogeneous catalysts, the main influencing
synthesis parameters are the metal precursor, the solvent,
and the stabilizing system. Preparations are generally one-
pot (direct) procedures but very different conditions have
been applied, leading to Pd(0) NPs through the presence
of a reductant such as a base, hydrogen, the stabilizer, and
most often NaBH₄. Examples of the formation of Pd(II)
NPs have also been reported from thermal decomposition
of preformed Pd complexes with water-soluble ligands
[33]. The application of these Pd aqueous suspensions falls
largely in the fields of C–C couplings and to a lesser extent
of hydrogenations. It appears to the best of our knowledge
that rare examples exist for oxidation reactions in water
[34–37].

We wish to report here a straightforward synthesis of Pd catalyst in the form of nanoparticles dispersed in water. The catalytic potential of these suspensions was assessed through oxidation reactions, rarely reported to date with Pd NPs water suspensions. We particularly studied the selective oxidation of benzylic alcohols as lignin model molecules. Indeed studies related to lignin oxidation often involve model molecules to discuss structure/reactivity of novel catalytic systems and highlight the importance of reaction parameters [38, 39].

**2 Experimental Section**

**2.1 Chemicals**

All reactants, reagents and products were used as received
from Sigma Aldrich except TiO₂ P25 (specific surface area
57 m² g⁻¹) obtained from Evonik.

**2.2 Synthesis of Pd NPs in Water**

A first solution was prepared by dissolving Na₂PdCl₄ (21 mg, 7.05×10⁻⁵ mol Pd) in HPLC-grade water (8 mL) at room temperature. A second solution was prepared by dissolving PVP K30 (MW ~ 40,000, 78 mg, 10 equiv./Pd) in HPLC-grade water (8 mL) at room temperature. Both solutions were mixed and stirred for 30 min. A third solution of NaBH₄ (6.7 mg, 2.5 equiv./Pd) in 4 mL of HPLC-grade water was quickly added into the previous mixture, leading to colour change from yellow to black. The obtained colloidal suspension of Pd nanoparticles (0.035 mol L⁻¹ of Pd) was stable over time and could be used for catalytic reactions 24 h after synthesis.

**2.3 Synthesis of Pd NPs on TiO₂**

Pd/TiO₂ was prepared by immobilisation of preformed Pd nanoparticles (see above). Prior to impregnation, the colloidal suspension of Pd NPs was adjusted to pH 2 by addition of HCl (10% in HPLC-grade water). TiO₂ P25 (750 mg) was then added and the mixture was stirred for 1 h at room temperature. The solid was filtered on Büchner, dried overnight (120 °C), and calcined under air flow (450 °C, 2 °C min⁻¹, N₂/O₂ 80/20, 60 mL min⁻¹) for 3 h. Reduction under H₂ flow (300 °C, 2 °C min⁻¹, 60 mL min⁻¹,) for 3 h followed by passivation with 1% O₂/N₂ (60 mL min⁻¹) for 30 min at room temperature led to a solid with 2.18 wt% of Pd.

**2.4 Nanoparticle Size Determination**

Suspended and supported Pd NPs were characterized using transmission electron microscopy on Jeol 2010 apparatus with LaB6 tip at 200 kV. For analysis, a dispersion of the sample crushed in ethanol was deposited on standard holey carbon-covered copper TEM grids. Metal particle size distributions have been determined using FIDJI image program from the measurement of around 200 particles in arbitrarily chosen areas from the images.
## 2.5 Pd Content Determination

Pd content was determined with an ICP-OES Activa from Horiba Jobin Yvon apparatus. The sample was dissolved with HCl/HNO₃ followed by complete water evaporation before heating further the residue in HCl.

## 2.6 Crystallinity Determination

Powder X-ray diffraction patterns were obtained on a Bruker D5005 spectrometer using a radiation Cu-Kα (λ = 1.054184 Å). Analysis was performed with DIFFRAC. EVA program.

## 2.7 Vanillic Alcohol, Veratryl Alcohol and Hydrobenzoin Oxidations

The reactions were performed in a 100 mL round-bottomed flask. A colloidal suspension of PVP stabilized Pd NPs (20 mL, 7.05 × 10⁻⁵ mol of Pd), or a dispersion of Pd/TiO₂ (277 mg, 7.05 × 10⁻⁵ mol Pd) in 20 mL of HPLC-grade water, was introduced in the flask. NaHCO₃ (400 mg) was added and the mixture heated at 80 °C under vigorous stirring. The reactant (7.05 × 10⁻³ mol for vanillic and veratryl alcohol, 100 equiv./Pd or 7.05 × 10⁻⁴ mol for hydrobenzoin, 10 equiv./Pd) was then added. The mixture was heated at the desired temperature stirred under air or O₂ flow, for a determined time with regular sampling for analysis.

## 2.8 Conversion and Yield Determination

Conversion and yields were determined using a Shimadzu GC-2030 gas chromatograph equipped with a FID detector (Phenomenex Zebron ZB-5HT column, He as carrier gas, T injection 300 °C, T detection 250 °C). Samples were prepared from regular sampling of 500 µL aliquots. Prior to analysis, aqueous samples were extracted with 1 mL of organic solvent (ethyl acetate for vanillic alcohol or dichloromethane for veratryl alcohol and hydrobenzoin experiments), in the presence of NaCl (200 mg). Yields are molar yields and determined through calibration of commercial samples with decane as external standard.

## 2.9 Recycling Experiments

After a first run, the organics were extracted with 5 mL of ethyl acetate (5 successive times) from the reaction medium until no vanillic alcohol nor vanillin were observed on GC analysis. Then a new charge of vanillic alcohol was added to the obtained aqueous phase and a second run was performed under identical conditions. This procedure was repeated for successive catalyst recycling.

# 3 Results and Discussion

## 3.1 Synthesis and Characterization of Water Suspensions of Pd(0) Nanoparticles

Several examples of dispersion of Pd(0) NPs in water stabilized by PVP have been reported, following varied synthetic conditions. Usually H₂PdCl₄, K₂PdCl₄ or Na₂PdCl₄ solutions are used as Pd sources, after conventional [40] or microwave heating [41]. Most often NaBH₄ serves as reductant [35, 42, 43] although examples exist using ethanol [41, 44] or even without additional reductant [45] particularly through electrochemical methods [46]. The obtained nanoparticles are of diverse average diameter size depending on the conditions, globally in the 2–5 nm range.

In the present work, we attempted to identify conditions to present a more straightforward synthetic procedure. In particular, colloidal suspensions were prepared at ambient temperature. Palladium precursor Na₂PdCl₄ was dissolved in water along with polyvinylpyrrolidone (PVP). Pd reduction occurred through addition of NaBH₄ in water and the mixture was stirred at room temperature. Different preparations were synthesized by varying the stoichiometry of PVP from 5, 10 and 25 molar equivalents (See Sect. 2 for details). This procedure led to colloidal suspensions with 0.035 mol L⁻¹ of Pd stable for months under ambient conditions.

As indicated by TEM images (Fig. 1), with PVP/Pd of 5, Pd particles were obtained with a 3.19 ± 1.63 nm average size, which is clearly in line with reported related systems. In this case, it appears that they were encapsulated in PVP micelles but their dispersion was not completely homogeneous. In the case of PVP/Pd of 10, Pd particles possess a mean diameter of 3.85 ± 0.94 nm with a homogeneous dispersion. In the presence of 25 equiv. of PVP, the mean diameter was much higher up to 6.64 ± 1.87 nm, with moreover the presence of aggregates. Therefore, among the three systems, that giving the most dispersed Pd nanoparticles with a relatively small average size was prepared with 10 equiv. of PVP. Therefore, this system was chosen for catalytic studies.

## 3.2 Synthesis and Characterization of Pd Nanoparticles Supported on TiO₂

The as-synthetized Pd NPs stabilized by PVP were used to prepare immobilized Pd NPs on TiO₂. TiO₂ was chosen since this usual support for heterogeneous catalyst preparation combines structural stability in water and relatively good surface area for Pd NPs immobilisation. The pH value of the suspension was adjusted to 2 by addition of aqueous HCl in order to favour ionic interaction with the support. After impregnation, calcination, reduction and passivation steps gave a Pd/TiO₂ material containing 2.18 wt% of
<figure><img src="image_3.png" /><figcaption>Fig. 1 TEM images and size distribution of Pd NPs prepared with a 5; b 10; c 25 molar equivalents of PVP in water</figcaption></figure>

<figure><img src="image_4.png" /><figcaption>Fig. 2 TEM images and size distribution of Pd NPs deposited on TiO$_{2}$</figcaption></figure>
Pd (see Sect. 2 for details). TEM images (Fig. 2) indicates that the preparation not only preserved the nice dispersion of the original nanoparticles without aggregation but also gave smaller nanoparticles with a mean diameter of $1.55 \pm 0.39$ nm.

To explain the presence of smaller particles, we performed a control experiment consisting of acidifying of a colloidal suspension, but without impregnation on $TiO_2$. TEM images (Fig. 3) of the resulting mixture indicates that acidification at pH 2.99 decreased the Pd particle sizes. Further acidification to pH 2.65 led to slight increase of the size. Indexing indicated the formation of a layer of palladium oxychloride during the acidification process. At lower pH of 2.00, this shell appeared to dissolve, releasing smaller Pd nanoparticles of lower distribution and agglomeration. When supported onto $TiO_2$ those NPs were of even smaller

size, certainly due to fast stabilization during deposition on the support.

The BET surface area of this material was $61 \text{ m}^2 \text{ g}^{-1}$ showing no significant difference compared to $TiO_2$ ($57 \text{ m}^2 \text{ g}^{-1}$). Moreover DRX analysis (Fig. 4) indicates that no modification of $TiO_2$ phases occurred during the synthesis, and as expected due to small particle size, the absence of signals from Pd.

### 3.3 Application to the Oxidation of Benzyl Alcohols

The catalytic properties of Pd NPs stabilised by PVP were evaluated in the oxidation of benzyl alcohols. We first studied the oxidation of vanillic alcohol, a simple lignin model. This substrate was chosen for determining the optimal reaction conditions using Pd NPs prepared with 10 equiv. of

<figure><img src="image_5.png" /><figcaption>Fig. 3 TEM images and size distribution of Pd NPs after progressive acidification of the suspension, a pH 2.99; b pH 2.65; c pH 2.00</figcaption></figure>
<figure><img src="image_6.png" /><figcaption>Fig. 4 X-ray diffractograms of TiO₂ and Pd/TiO₂</figcaption></figure>

PVP. Oxidation of vanillic alcohol can theoretically form the corresponding aldehyde (vanillin) and carboxylic acid (vanillic acid). Note that the latter is rarely formed over classical metallic catalysts [47] while most often obtained with enzymatic catalysts [48] (Scheme 1).

First set of experiments were performed under air flow at 50 and 80 °C, with or without NaHCO₃ as base. These conditions were not optimized and realized to observe first tendencies as presented in Fig. 5. Thus, in the absence of a base the transformation was quite efficient for the formation of vanillin with yield of 90–95% after 8 h. The temperature had only a slight influence at the beginning but allows as expected a faster global transformation at 80 °C. The presence of NaHCO₃, despite giving close apparent initial rate of reaction, increased significantly the reaction time for maximum vanillin formation. The presence of the base can deactivate the catalyst, or led more probably after a certain

time to uncontrolled reactivity of vanillin, successively to its continuous formation. A control experiment confirmed that vanillin was not stable in such conditions after expanded reaction time. Indeed, vanillin treated in the same condition was converted up to 75% after 15 h. As for the experiments performed in the absence of a base, no vanillic acid was observed, excluding therefore this way of transformation. Although we could not definitively identify corresponding products one can propose for example vanillin degradation through aromatic ring opening or even condensation to higher molecular mass compounds [49].

These first results indicate that the Pd NPs aqueous suspension is catalytically active for oxidation reactions and a fine tuning of the conditions has appeared necessary for a more efficient transformation. Therefore we performed the reaction in the presence of O₂ atmosphere in place of air to assess possible balance of reaction time and oxidant

<figure><img src="image_7.png" /><figcaption>**Scheme 1** Vanillic alcohol oxidation</figcaption></figure>
<figure><img src="image_8.png" /><figcaption>Fig. 5 Vanillic alcohol oxidation with Pd NPs stabilized by PVP under air</figcaption></figure>

<table><caption>**Table 1** Vanillic alcohol oxidation with Pd NPs stabilized by PVP under O₂</caption><thead><tr><th>Entry</th><th>Time (h)</th><th>T (°C)</th><th>NaHCO<sub>3</sub> (g L<sup>-1</sup>)</th><th>Yield of vanillin (%)<sup>a</sup></th></tr></thead><tbody><tr><td>1</td><td>3</td><td>80</td><td>0</td><td>100</td></tr><tr><td>2</td><td>3</td><td>80</td><td>5</td><td>65</td></tr><tr><td>3</td><td>6</td><td>80</td><td>10</td><td>100</td></tr><tr><td>4</td><td>1</td><td>80</td><td>20</td><td>91</td></tr><tr><td>5<sup>b</sup></td><td>1</td><td>80</td><td>20</td><td>80</td></tr><tr><td>6<sup>b</sup></td><td>1</td><td>80</td><td>20</td><td>66</td></tr><tr><td>7<sup>c</sup></td><td>1</td><td>80</td><td>20</td><td>36</td></tr></tbody></table>

H₂O (20 mL); substrate 100 mol equiv./Pd; Pd: 7.05×10⁻⁵ mol; air flow, ambient pressure

ᵃMaximum yield observed

ᵇ1st and 2nd recycling

ᶜIn the presence of Pd/TiO₂

concentration. Thus in this second set of experiments, various conditions under O₂ were evaluated (Table 1). Interestingly in the absence of a base, a complete vanillin formation was obtained at 80 °C within a much shorter reaction time of 3 h (entry 1) than using air as oxidant. This clearly confirms the positive influence of O₂ concentration. Next, the presence of a base gave results somewhat difficult to rationalize (entries 2–4). While lowest concentrations of 5 and 10 g L⁻¹ did not seem to influence the reaction, even at longer reaction times, the presence of 20 g L⁻¹ allowed a very fast transformation and a yield up to 91% could be obtained

after 1 h (entry 4). Note that at this level of base concentration, a noticeably short reaction time was mandatory since a decrease of vanillin yield was also clearly observed while keeping reaction running, as discussed above.

All these tendencies indicate the efficiency of this easily prepared aqueous suspension of Pd nanoparticles as catalyst without the need of purification of catalyst synthesis medium. In the literature there are not many reports of the aerobic oxidation of vanillic alcohol into vanillin with Pd-based catalysts. Examples with supported Pd such as Au–Pd/C(or HT) [50], Au–Pd/TiO₂ [51], Pd/MIL-101 [52], Pd/MgO [53], Pd/MCF [54] or Pd/Cu-chlorophosphate [55] gave interesting results at temperatures from 25 to 170 °C, however in organic solvents like dioxane, toluene or alcohols. It seems that the only example of this reaction in water using single Pd metal was performed using an immobilized Pd(0)-pyridyl-based molecular complex on SBA-15 giving 99% yield of vanillin (80 °C, 7 h, N₂ or air atmosphere, 325 equiv. of Pd) [12, 56]. Therefore, the present results are clearly in line with reported works.

Recyclability has been studied (see Sect. 2 for details). First, as shown in Fig. 6, the Pd suspension appeared to be stable after reaction since no Pd deposit was observed. Then, the organic products were extracted from the reaction medium with EtOAc leaving the catalytic system in the aqueous phase. After addition of vanillic alcohol only, another run was performed under same conditions. Results indicates that the Pd NPs were still active despite a loss of efficiency (Table 1, entries 5–6). TEM images and size distribution (Fig. 7) of Pd nanoparticles after the third run
<figure><img src="image_9.png" /><figcaption>**Fig. 7** TEM images and size distribution of Pd NPs after the third run</figcaption></figure>

confirmed the stability of the suspension with well dispersed NPs of 2.92 ± 0.85 nm average size, in the same range as before the catalytic reactions. For each recycling, ICP analysis indicates the presence of 0.04% of initial Pd in the organic solution. Despite the fact that this corresponds to a very light loss of Pd from the original suspension, this may be a possibility for the lesser vanillin formation.

Using these last conditions, the potential of Pd/TiO₂ material prepared from the NPs/PVP nanoparticles was compared to that of the parent NPs/PVP suspension (Table 1, entry 7). Here a significant lower efficiency led to a moderate maximum yield of 36% after 1 h.

Based on this, the potential of the NPs suspension was assessed for the oxidation of other substrates modelling the lignin structure under the same conditions [57] (Table 2). First we observed that the reaction was less efficient using 2-methoxybenzyl alcohol (entry 1) with a maximum yield of 21%. Here the presence of a methoxy substituent at the *ortho* position partly prevents the transformation. This phenomenon has been recently observed with Pd-catalysts under similar conditions and steric hindrance was given as

the reason for this lower reactivity [58, 59]. Veratryl alcohol oxidation was rarely reported using Pd catalysts, even more with O₂ as oxidant [60–65]. Here, veratryl alcohol reacted similarly to vanillic alcohol with the Pd NPs suspension leading to 83% of veratraldehyde after 2 h (entry 2). This is not surprising since veratryl alcohol structure only slightly differs from vanillic alcohol. Hydrobenzoin is a more sophisticated reactant having vicinal secondary alcohol functions as can be encountered within the lignin structure. Here, it was possible to obtain 58% of benzoin with nice selectivity after 5 h with the Pd NPs suspension (entry 3). Therefore no (PhCO)₂ benzil nor C–C cleavage products (e.g. benzylddehyde) were observed. While some reports exist with for example homogeneous Mn/H₂O₂ systems [57, 66], to the best of our knowledge this is the first example of the oxidation of this compound in the presence of a Pd/O₂/water system [67–69]. This is encouraging for the transformation of more functionalized substrates.

In all cases the colloidal suspension of Pd has proven to be much more efficient than Pd/TiO₂ which was particularly not able to transform hydrobenzoin. Note that optimization
<table><caption>**Table 2** 2-Methoxybenzyl alcohol, veratryl alcohol and hydrobenzoin oxidation under O₂</caption><thead><tr><th>Entry</th><th>Catalytic system</th><th>Time (h)</th><th>Substrate</th><th>Product</th><th>Conv/yield (%)</th></tr></thead><tbody><tr><td>1</td><td>Pd NPs suspension</td><td>3</td><td></td><td></td><td>50/21</td></tr><tr><td>2</td><td>Pd NPs suspension</td><td>2</td><td>2-methoxybenzyl alcohol<br>veratryl alcohol</td><td>2-methoxybenzaldehyde<br>veratraldehyde</td><td>100/83</td></tr><tr><td>3</td><td>Pd/TiO<sub>2</sub></td><td>6</td><td></td><td></td><td>45/38</td></tr><tr><td></td><td>Pd NPs suspension</td><td>5</td><td>hydrobenzoin</td><td>benzoin</td><td>59/58</td></tr><tr><td></td><td>Pd/TiO<sub>2</sub></td><td>6</td><td></td><td></td><td>0.6/0.5</td></tr></tbody></table>

H₂O (20 mL); substrate 10 molar equiv./Pd, Pd: 7.05 × 10⁻⁵ mol; O₂ flow, 80 °C, NaHCO₃ 20 g L⁻¹, ambient pressure

of conditions has not been attempted with Pd/TiO₂ but these results nevertheless highlight the probably higher accessibility of the Pd nanoparticles dispersed in water than supported on TiO₂, and that the particle size of the metal phase appeared to be not an exclusive parameter governing that reactivity.

## 4 Conclusion

We have presented an easy procedure for the synthesis of Pd nanoparticles in water stabilised by PVP. Nanoparticles of 3.85 nm with good dispersion were obtained. This mixture was used to prepare Pd/TiO₂ leading to a material having 2.18 wt% of Pd in the form of nanoparticles with a mean diameter of 1.55 ± 0.39 nm. These two systems were used as catalysts for the oxidation of benzyl alcohols as lignin model molecules in water. While Pd/TiO₂ presented relatively low efficiency, Pd nanoparticles suspension showed high potential for vanillic alcohol aerobic oxidation in basic medium under mild conditions of pressure and temperature, with a possibility of catalytic system reuse acting therefore as “quasi-homogeneous catalyst”. This system was also efficient for the oxidation of more complex lignin model molecules as veratryl alcohol or hydrobenzoin.

**Acknowledgements** The authors thank the French National Research Agency for funding through NANOTRAP Project

(ANR-17-CE07-0027). The authors thank L. Burel (IRCELYON) for precious discussion concerning TEM analysis.

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