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# Recent achievements in the synthesis and reactivity of pentafluorosulfanyl-alkynes

Floriane René, Leo Clement-Comoy, Nicolas Blanchard, Vincent Bizet

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Floriane René, Leo Clement-Comoy, Nicolas Blanchard, Vincent Bizet. Recent achievements in the synthesis and reactivity of pentafluorosulfanyl-alkynes. Comptes Rendus. Chimie, 2024, 27 (G1), pp.227-240. 10.5802/crchim.350. hal-05377233

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Submitted on 24 Nov 2025

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Distributed under a Creative Commons Attribution 4.0 International License
Comptes Rendus
Chimie

Floriane René, Léo Clément-Comoy, Nicolas Blanchard and Vincent Bizet

Recent achievements in the synthesis and reactivity of pentafluorosulfanyl-alkynes

Volume 27 (2024), p. 227-240

Online since: 7 November 2024

https://doi.org/10.5802/crchim.350

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This article is licensed under the
CREATIVE COMMONS ATTRIBUTION 4.0 INTERNATIONAL LICENSE.

http://creativecommons.org/licenses/by/4.0/
Review article

# Recent achievements in the synthesis and reactivity of pentafluorosulfanyl-alkynes

Floriane René<sup>®,*a</sup>, Léo Clément-Comoy<sup>®,*a</sup>, Nicolas Blanchard<sup>®,*a</sup> and Vincent Bizet<sup>®,*,*a</sup>

<sup>a</sup> Université de Haute-Alsace, Université de Strasbourg, CNRS, LIMA, UMR 7042, 3bis rue Werner, 68000 Mulhouse, France

E-mail: vbizet@unistra.fr (V. Bizet)

**Abstract.** In the dynamic field of pentafluorosulfanyl (SF₅) chemistry, the SF₅-alkynes have emerged as essential, readily accessible, and modular building blocks for the construction of a wide variety of SF₅-containing molecules. This polarized platform has been used to perform highly regio-, chemo-, and stereoselective transformations such as heterocycle synthesis, cycloaddition, and hydroelementation reactions. This brief review provides an overview of recent developments in the synthesis and reactivity of SF₅-alkynes, which are fascinating building blocks that have yet to reveal their full synthetic potential.

**Keywords.** Pentafluorosulfanyl, SF₅-alkyne, Cycloaddition, Hydrofunctionalization, Regioselective, Stereoselective.

Manuscript received 18 July 2024, revised 9 September 2024, accepted 27 September 2024.

## 1. Introduction

Often compared to trifluoromethyl (CF₃), the pentafluorosulfanyl (SF₅) group is an emerging fluorinated group that has experienced exponential growth over the years, finding numerous applications in life and material sciences (for reviews on SF₅, see [1-6]). This is due to a unique combination of physicochemical properties such as a large volume between CF₃ and *tert*-butyl, an octahedral geometry, a high electronegativity (3.65 vs 3.36 for the CF₃) combined with a high lipophilicity, which makes this SF₅ group highly polar and lipophilic. SF₅-alkynes are readily available substrates, easily prepared from terminal alkynes, which have been used as SF₅-building blocks in many transformations [7]. This short review/account is the follow-up to the review article we have published in 2022 [7] and it is mainly dedicated to the latest developments of SF₅-alkynes from their preparation to the synthetic applications.

## 2. Pentafluorosulfanylation of alkynes

### 2.1. *Chloropentafluorosulfanylation*

For the last two decades, the most efficient and reliable method to carry out chloropentafluorosulfanylation of alkynes 1 has been the Dolbier's procedure using SF₅Cl in hexane under free radical conditions initiated by triethylborane/oxygen [8]. Like all methods, this one suffers from certain limitations, such as a restricted substrate range (2) and the formation of some dimeric by-products 3 (Scheme 1). Since then, several scientific groups have developed alternative conditions for the activation and/or generation of SF₅Cl to broaden the scope and reactivity.

In 2021, Paquin and co-workers developed an alternative activation strategy to generate the SF₅ radical from SF₅Cl by using an electron donor-acceptor (EDA) complex and visible light irradiation for the chloropentafluorosulfanylation of alkenes and alkynes (Scheme 2) [9]. A mechanism was proposed starting with the in-situ formation of enamine 5 from 2,2-diphenylacetaldehyde and pyrrolidine.

<footnote>* Corresponding author</footnote>
<figure><img src="image_5.png" /><figcaption>**Scheme 1.** Radical chloropentafluorosulfanylation of terminal alkynes initiated by triethylborane.</figcaption></figure>

<figure><img src="image_6.png" /></figure>

Proposed mechanism

<figure><img src="image_7.png" /><figcaption>**Scheme 2.** Radical chloropentafluorosulfanylation of terminal alkynes initiated by EDA-complex under visible light irradiation.</figcaption></figure>

The EDA complex **6** is then formed by halogen bonding with the chlorine atom of SF₅Cl. Under visible light irradiation from a 23 W compact fluorescent lamp (CFL), the SF₅ radical is formed together with the radical cationic enamine **7** and the chlorine anion. The SF₅ radical is selectively introduced at the terminal position of the alkyne (to generate the vinyl radical **8**), while the chlorine atom could originate from SF₅Cl by radical propagation or by recombination of **8** with a chlorine radical released during the regeneration of **5**.

In 2022, Qing and co-workers developed the synthesis of SF₅-alkynes by radical addition of SF₅Cl to ethynylbenziodoxolone derivatives **9** under blue light irradiation [10]. According to the proposed mechanism, the SF₅ radical is generated by light irradiation at 440 nm, followed by addition onto the triple bond of the EBX reagent. The elimination of the adduct (**10**) then allows the direct formation of a SF₅-alkyne **4**. This method gives access to SF₅-alkynes in yields ranging from 49 to 76% yield (Scheme 3).

Light activation of SF₅Cl was also used by the Paquin's group in 2023 for the addition onto alkenes and alkynes **1** [11]. This time, the reaction is activated by exposing the SF₅Cl solution to black light (370 nm), which initiates the radical chain process. This new methodology provides access to various chloro-olefins **2** from terminal alkynes in moderate to good yields. An example of an internal alkyne is also reported, yielding a single regio- and stereoisomer (Scheme 4).

In 2024, Cahard, Bizet and co-workers published a simple regio- and stereoselective method for the chloropentafluorosulfanylation of alkynes with SF₅Cl in THF at -40 °C [12]. In contrast to other methods [8-11], performing the reaction in THF alone was sufficient to initiate the radical addition, yielding exclusively (*E*)-1-chloro-2-SF₅-alkenes **2** without the use of radical initiator or light activation (Scheme 5). The formation of the SF₅ radical was proposed to be initiated by hydroperoxides **11** formed from the autoxidation of THF with oxygen. Addition of the SF₅ radical to the terminal position of the alkyne resulted in a vinylic radical **8**, which was chlorinated by chlorine abstraction of SF₅Cl, allowing the chain propagation. The stereochemistry of these (*E*)-1-chloro-2-SF₅-alkenes **2** was definitively established by single crystal X-ray diffraction (SCXRD). Both aromatic and aliphatic alkynes reacted with good to excellent yields under these conditions. This method is of great interest and complementary to previous ones, since SF₅-alkynes with electron-deficient aromatic rings or heteroaromatic substituents are now accessible, and the formation of the dimeric by-product observed under Dolbier's conditions is significantly reduced. Notably, hetero-substituted alkynes with a silyl- or boron-motif were also competent substrates. The method is not limited to terminal alkynes, as polarized internal alkynes such as ynoates or ynones were efficiently converted. In this case, the SF₅ was introduced regioselectively at the α-position of the C=O, affording the product as a single *E*-isomer.
<figure><img src="image_8.png" /><figcaption>**Scheme 3.** Chloropentafluorosulfanylation of ethynylbenziodoxolone derivatives under blue light irradiation.</figcaption></figure>

<figure><img src="image_9.png" /><figcaption>**Scheme 4.** Chloropentafluorosulfanylation of alkynes under black light irradiation.</figcaption></figure>

In the same year, Wang and co-workers used variously substituted 1,3-enynes **13** as starting materials for chloropentafluorosulfanylation under copper-catalyzed conditions [13]. Depending on the substitution, they observed the 1,2-difunctionalization (with R¹, R² = H) to afford **14** or the 4,3-difunctionalization (with R⁴ = H) to give **15** (Scheme 6). Interestingly, a phenyl substituent at the C2 position (R³) induced the formation of the SF₅-substituted allene **16**. A radical pathway for this transformation was proposed on the basis of experimental mechanistic studies. The SF₅ radical was generated by a single electron transfer (SET) induced by the Cu(I)-bipyridyl species. The SF₅ addition took place preferentially at the terminal position of the olefin or alkyne, together with the formation of a vinyl (**17**), propargyl (**18**) or allenyl radical (**19**) (due to the formation of more stable secondary or tertiary radicals) and subsequent chlorine abstraction, which

regenerated the SF₅ radical. Several transformations such as hydrodechlorination, hydrostannation or dehydrochlorination under basic conditions have also been proposed as synthetic applications.

Efforts to avoid the direct manipulation of the costly and toxic SF₅Cl are ongoing, as demonstrated by the group of Tlili in 2022, who developed the pentafluorosulfanylation of alkynes starting from SF₆, an inert, non-toxic, but known potent greenhouse gas (Scheme 7) [14]. They developed the activation of SF₆ using tetrakis(dimethylamino)ethylene (TDAE) under a blue light (455 nm) irradiation. The TDAE excited state performs a two-electron reduction on SF₆, forming the ion pair intermediate SF₅⁻/TDAE²⁺/F⁻ (**20**). Using a two-chamber system, the resulting intermediate can then react with TCICA to produce SF₅Cl in situ in the first tube, which can then be transferred to the second tube to carry out the pentafluorosulfanylation of various alkynes **21**.
<figure><img src="image_10.png" /><figcaption>**Scheme 5.** Chloropentafluorosulfanylation of alkynes using SF<sub>5</sub>Cl in THF.</figcaption></figure>

<figure><img src="image_11.png" /><figcaption>**Scheme 6.** Copper-catalyzed chloropentafluorosulfanylation of 1,3-enynes.</figcaption></figure>
<figure><img src="image_12.png" /><figcaption>**Scheme 7.** In-situ generation of SF₅Cl from SF₅⁻/TDAE²⁺/F⁻ salt.</figcaption></figure>

with moderate to good yields with or without the use of triethylborane as a radical initiator.

In another approach, De Borggraeeve and co-workers developed in 2023 the in-situ generation of SF₅Cl by oxidative fluorination of 4,4'-dipyridyl disulfide **23** (Scheme 8) [15]. The reaction was carried out in the presence of TCICA as chlorine source and KF in acetonitrile at room temperature as reported by Pitts, Santschi, and Togni [16,17]. A two-chamber reactor was used to generate SF₅Cl in the first chamber, which was then reacted in the second chamber by radical addition of SF₅Cl to alkynes **25**, alkenes, and 2-diazo-1-phenylethan-1-one under Dolbier's conditions, to afford the corresponding products **26** in moderate to good yields.

## 2.2. Iodopentafluorosulfanylation

In 2023, Cahard, Bizet, Legault and co-workers developed a method for the iodopentafluorosulfanylation of alkynes which led exclusively to (E)-1-iodo-2-SF₅ alkenes **28** as confirmed by SCXRD [18]. The optimal conditions consisted in mixing a terminal alkyne **27**, SF₅Cl, potassium iodide and 18-crown-6-ether in THF at -78 °C resulting in regio- and stereoselective access to unprecedented (E)-1-iodo-2-SF₅ alkenes **28** (Scheme 9). The addition of 18-crown-6-ether improved the nucleophilicity of the iodide and the use of THF instead of hexane significantly increased conversion and yield. Conducting the reaction at -78 °C was necessary to avoid the formation of the diiodo alkene side product. Other sources of iodide were also tested but were not as efficient as potassium

iodide in achieving this conversion. For aromatic alkynes and one internal alkyne, only 1-iodo-2-SF₅-products were observed, whereas aliphatic alkynes gave mixtures of 1-iodo- and 1-chloro-2-SF₅-alkenes due to a competing reaction pathway with SF₅Cl in this case. A detailed mechanistic investigation was carried out and supported by DFT calculations. It was found that a radical chain mechanism is more likely to be responsible for the addition of SF₅ at the terminal position of the alkyne, whereas an anionic mechanism would give the opposite regioselectivity. It was clearly shown that the formation of SF₅I, as a reagent itself, cannot be thermodynamically feasible and that the most probable reaction pathway is as follows: after the in-situ generation of the SF₅⁻ (30, observed by ¹⁹F NMR), the latter is oxidized by a single electron transfer (SET) with I₃⁻ to form the SF₅· radical which undergoes classical radical addition onto alkyne (27a) to give a vinyl radical **32a**. The abstraction of iodine from ICl is then much more favored with aromatic substrates than the abstraction of chlorine (28a vs 33a).

## 2.3. Hydropentafluorosulfanylation

In 2022, Paquin, Champagne, and co-workers reported a photoinitiated anti-hydropentafluorosulfanylation of terminal alkynes in favor of the Z isomer **35** (>85% Z-selective) [19]. The reaction required SF₅Cl as a source of SF₅ radical and (TMS)₃SiH acting as a hydrogen atom donor (HAD) species (Scheme 10). Due to the competitive chlorine abstraction by the vinylic radical resulting
<figure><img src="image_13.png" /><figcaption>**Scheme 8.** In-situ generation of SF<sub>5</sub>Cl from oxidative fluorination of 4,4′-dipyridyl disulfide.</figcaption></figure>

<figure><img src="image_14.png" /><figcaption>**Scheme 9.** Iodopentafluorosulfanylation of alkynes using SF<sub>5</sub>Cl, KI and 18-crown-6-ether in THF.</figcaption></figure>

in 1-chloro-2-SF<sub>5</sub> alkenes, gaseous SF<sub>5</sub>Cl was added incrementally to artificially lower its concentration, thereby favoring the hydrogen atom transfer (HAT). Using a black light CFL bulb, a SF<sub>5</sub> radical is generated from the photochemical activation of SF<sub>5</sub>Cl. Its addition to terminal alkynes gives a bent or a linear vinylic radical (36, 36'), depending on the nature of the substituent, which is then captured by the

HAD that provides 35. A wide range of substrates were used, such as aromatic or aliphatic alkynes, and even ynones, which showed good reactivity under these conditions. A detailed DFT calculation study showed that the selectivity is due to the intrinsic preference of SF<sub>5</sub>-substituted vinylic radicals to adopt a cis-geometry, and to the reduced distortion in the transition structures.
<figure><img src="image_15.png" /><figcaption>**Scheme 10.** Photoinitiated hydropentafluorosulfanylation of alkynes using SF<sub>5</sub>Cl and (TMS)<sub>3</sub>SiH.</figcaption></figure>

<figure><img src="image_16.png" /><figcaption>**Scheme 11.** Synthesis of 2-SF<sub>5</sub>-(aza)indoles and further derivatization.</figcaption></figure>

**3. Cycloaddition and cyclization reactions of SF<sub>5</sub>-alkynes**

SF<sub>5</sub>-Alkynes are very versatile small building blocks that have been found to be relevant reaction partners in [4+2] Diels-Alder cycloadditions and 1,3-dipolar cycloadditions [7]. In 2021, Bizet, Blanchard and co-workers reported an efficient synthesis of 2-SF<sub>5</sub>-(aza)indoles **39** starting from 2-ethynyl aniline derivatives **37** via a 3-step telescoped procedure

(Scheme 11) [20]. The first step is the classical radical addition of SF<sub>5</sub>Cl to a 2-ethynyl aniline **37** initiated by triethylborane to give intermediate **38**. The reaction was very efficient in ethyl acetate, and required room temperature to reach completion. The reaction was therefore carried out in sealed tubes to keep the gas in solution. Treatment with LiOH·H<sub>2</sub>O in DMSO produced a cascade of dehydrochlorination, 5-endo-dig cyclization, and deprotection of the tosyl fragment, giving 2-SF<sub>5</sub>-indole **39** in good to high yields.
<figure><img src="image_17.png" /><figcaption>**Scheme 12.** Synthesis of SF<sub>5</sub>-pyrazoles under flow conditions.</figcaption></figure>

The sequence was then deconstructed and carried out stepwise. The dehydrochlorination was highly selective using LiHMDS as base and the corresponding alkynes **40** were formed in almost quantitative yields. The 5-endo-dig cyclization was then carried out with K<sub>3</sub>PO<sub>4</sub>, with conservation of the tosyl fragment expected for substrates with strong electron-withdrawing groups, where a mixture of NH **39** and N-Ts indoles **41** was observed. Downstream functionalizations at the N and C3 positions provided various *N*-protected and 3-halogenated 2-SF<sub>5</sub>-indoles, which were further involved in Negishi and Heck cross-couplings, or even allylation and cyanation after halogen/metal exchange. In addition to the synthetic part, several physicochemical measurements were carried out with 2-R<sub>f</sub>-indoles (R<sub>f</sub> = H, Me, F, CF<sub>3</sub>, and SF<sub>5</sub>) in order to better evaluate the impact of the SF<sub>5</sub> motif. Differential scanning calorimetry (DSC) measurements showed that 2-SF<sub>5</sub>-indoles **39** are high-energy materials with an onset of exotherm above 165 °C with an enthalpy of -1180 kJ/kg, compared to the 2-F-indoles (>120 °C, -623 kJ/kg) and 2-CF<sub>3</sub>-indoles (>325 °C, -403 kJ/kg). However, the synthesis of 2-SF<sub>5</sub>-indoles has a rather large safety margin gap (>120 °C) between the temperature of the reaction sequence (up to 40 °C max.) and the exotherm. The mutagenic potential of 2-SF<sub>5</sub>-indoles was evaluated by a classical biological test known as the "Ames test", using different histidine-requiring bacterial strains of *Salmonella typhimurium* carrying mutations in the genes in the absence and presence of a liver metabolizing system. No evidence of mutagenicity was observed with 2-SF<sub>5</sub>-indoles, which

means that they can potentially be used for further development in drug design. Finally, the pKa and logP of the 2-R<sub>f</sub>-indoles were measured by Leito's group, which showed a 2.3 pKa unit difference between the 2-SF<sub>5</sub>- and 2-CF<sub>3</sub>-indoles (pKa = 24.44 for SF<sub>5</sub> vs 26.76 for CF<sub>3</sub> in MeCN), confirming that SF<sub>5</sub> is a stronger electron-withdrawing group than CF<sub>3</sub>, while the lipophilicity is in the same range (3.8 ± 0.2 for SF<sub>5</sub> vs 3.5 ± 0.2 for CF<sub>3</sub>).

In 2024, the Paquin's group proposed a synthesis of substituted SF<sub>5</sub>-pyrazoles by 1,3-dipolar cycloaddition of ethyl diazoacetate with SF<sub>5</sub>-alkynes under flow conditions (Scheme 12) [21]. The use of flow conditions was motivated by the potential hazards associated with the heating of diazo compounds. Although both isomers **44** and **45** of the pyrazoles were obtained in all the cases, the regioselectivity was mainly induced by the substituent on the SF<sub>5</sub>-alkynes. 3-SF<sub>5</sub>-Pyrazoles **44** were the main products obtained from alkyl-substituted SF<sub>5</sub>-alkynes, whereas aryl-substituted SF<sub>5</sub>-alkynes preferentially gave 4-SF<sub>5</sub>-pyrazoles **45**, regardless of the electronic nature of the substituents. The methodology was extended to CF<sub>3</sub>-pyrazoles, this time with reversed regioselectivity. Some post-functionalization reactions were successfully applied to these pyrazoles, such as acetylation to give *N*-acetylpyrazole whereas the ester moiety was reduced to a terminal alcohol or hydrolyzed to form a carboxylic acid group.

In 2024, the Bizet group reported the palladium-catalyzed synthesis of 2-SF<sub>5</sub>-indenols and indenamines **48** from SF<sub>5</sub>-alkynes **47** and 2-formyl
<figure><img src="image_18.png" /></figure>

**Proposed mechanism**

<figure><img src="image_19.png" /></figure>

**Representatives examples**

<figure><img src="image_20.png" /><figcaption>**Scheme 13.** Palladium-catalyzed synthesis of 2-SF₅-indenols and further derivatizations.</figcaption></figure>

phenylboronic acid derivatives **46** (Scheme 13) [22]. The scope of the reaction is very general and can be realized either from a boronic acid, a boronic ester or even a potassium trifluoroborate salt in similar yields. The proposed mechanism proceeds by a transmetallation between the L-Pd-OR species (I) and the boronic acid **46** to generate the intermediate **III**, which, after coordination with the SF₅-alkyne (IV), undergoes a regioselective migratory insertion (V) controlled by the polarization of the SF₅-alkyne towards the SF₅. Then, migratory insertion to the formyl fragment (VI) and ligand exchange with the alcoholic solvent yields the 2-SF₅-indenol.

The 2-SF₅-indenol **48** was further oxidized with MnO₂ to give the corresponding 2-SF₅-indenone **49**. Downstream functionalizations such as nitration reaction, 1,2 and 1,4-nucleophilic additions with N- and S-nucleophiles were designed. The 1,4-nucleophilic addition (**50**) was found to be highly diastereoselective due to the steric constraint imposed by the bulky SF₅ group.

### 4. Hydrofunctionalization of SF₅-alkynes

The Rombach group investigated the reactivity of triisopropylsilyl acetylene sulfur pentafluoride (TASP).
<figure><img src="image_21.png" /><figcaption>**Scheme 14.** Hydroamination of triisopropylsilyl acetylene-SF₅ using secondary amines, AcOH and KF.</figcaption></figure>

They first reported a diastereoselective hydroamination reaction for the synthesis of (E)-β-SF₅-enamines **52** (Scheme 14) [23]. The product is formed by a one-pot sequence of in-situ deprotection of the TIPS with potassium fluoride in the presence of acetic acid, leading to the formation of several intermediates including enolacetate **51**. The hydroamination step is carried out with acyclic or cyclic secondary amines yielding exclusively (E)-β-SF₅-enamines **52**. A very small energy difference was calculated by DFT between the *E*- and *Z*-nucleophilic addition to SF₅-acetylene, making this pathway unlikely. The enolacetate **51** is proposed as a reactive intermediate leading to the formation of the thermodynamically most stable *E*-enamines **52**.

Shortly afterwards, the same group succeeded in using TASP in a hydrothiolation reaction. The β-SF₅-vinyl sulfides **54** were obtained under similar conditions by mixing TASP with a thiol as nucleophile, acetic acid and cesium fluoride in acetonitrile (Scheme 15) [24]. These conditions were applied to a wide range of thiol derivatives including aromatic, heteroaromatic, and aliphatic thiols. Even tertiary alkyl SF₅-vinyl sulfides could be obtained with slightly modified reaction conditions. In contrast with the hydroamination, the hydrothiolation yields only the (Z)-isomer. In this case, the proposed mechanism based on DFT calculations suggested an ionic pathway with direct nucleophilic attack of the thiol on SF₅-acetylene **53**.

Simultaneously and independently, the Bizet group has reported the regio- and stereoselective hydroelementation of SF₅ alkynes **56** with O-, N-, and S-nucleophiles **57**, where the nucleophile is introduced

exclusively at the Cβ of the SF₅-alkynes, giving in all cases the β,Z-product **58**, whatever the nature of the nucleophile (Scheme 16) [25]. The reaction was carried out in the presence of a base to maintain good reactivity for all the nucleophiles; it was shown that the same procedure could be applied directly from the SF₅-chloro-olefins **55**, giving the same selectivity by successive dehydrochlorination/hydroelementation steps in a single pot. With reactive nucleophiles such as pyrrolidine or piperidine, the hydrolysis of the intermediate enamine **60** was carried out with HBF₄ solution yielding the corresponding SF₅ ketones **61** in moderate to good yields. Experimental and computational mechanistic studies were performed and confirmed an ionic mechanism in which the nucleophile, deprotonated by the base (62), selectively attacks the triple bonds at the most electron deficient Cβ of the SF₅-alkynes, while the intermediate carbanion **63** is rapidly reprotonated in the reaction medium. The origin of the selectivity was explained by DFT calculations considering several aspects. The privileged attack at the Cβ is favored because of the polarization of the SF₅-alkyne and the slightly electrophilic character of this position, as shown by the calculation of natural charges from a Natural Population Analysis (NPA) of the SF₅-alkyne **56**, which are +0.09 for the Cβ and -0.030 for the Cα (with R = *p*-Ph-C₆H₄). Moreover, the Z-isomer **58** appeared to be kinetically favored (ΔG‡ = 21.7 kcal/mol) compared to the *E*-isomer (ΔΔG‡ ≈ 5 kcal/mol), while the β-selectivity was confirmed by a greater steric repulsion (ΔEPauli) in the attack on Cα. Some downstream functionalizations of **58** were revealed, such as cross-coupling reactions, halogenations, and reductions.
<figure><img src="image_22.png" /><figcaption>**Scheme 15.** Hydrothiolation of triisopropylsilyl acetylene-SF<sub>5</sub> using thiols, AcOH, and CsF.</figcaption></figure>

<figure><img src="image_23.png" /><figcaption>**Scheme 16.** Regio- and stereoselective hydroelementation of SF<sub>5</sub>-alkynes with N, O, S-nucleophiles.</figcaption></figure>

The SF<sub>5</sub>-ketones **61** were also subjected to Bayer–Villiger oxidation and reduction with NaBH<sub>4</sub> to give the corresponding ester or alcohol in good to high yields.

In 2024, Shibata and co-workers developed a regio- and stereoselective hydrofluorination of RSF<sub>4</sub>- and SF<sub>5</sub>-alkynes to give (Z)-RSF<sub>4</sub>- and (Z)-SF<sub>5</sub>-vinyl fluorides (Scheme 17) [26], using the SF<sub>5</sub>-alkyne **64** as the electrophile with TBAF·3H<sub>2</sub>O as the fluoride source (nucleophile). The reaction was found to

be efficient with aryl-substituted SF<sub>5</sub>-alkynes, giving good yields, while alkyl derivatives showed a poor stability. The mechanism of the reaction was discussed using DFT calculations and confirmed that the formation of the β,Z-isomer **67** was favored by 3.7 kcal/mol, which explains the very high selectivity. The proposed mechanism starts with a nucleophilic attack of the fluoride on the electron-deficient C<sub>β</sub> (**65**), which generates a carbanion on C<sub>α</sub> (**66**), which is rapidly protonated with water. The Z/E
<figure><img src="image_24.png" /><figcaption>**Scheme 17.** Hydrofluorination of SF<sub>5</sub>-alkynes with TBAF solution.</figcaption></figure>

interconversion was calculated to be strongly disfa-
vored ($\Delta G^{\ddagger} = 49.8$ kcal/mol).

At the same time, Bizet and co-workers reported a stereodivergent hydrohalogenation of SF<sub>5</sub>-alkynes, providing access to a wide range of β,Z- and β,E-halogenated SF<sub>5</sub>-alkenes 69–76 with all the halogens (Scheme 18) [27]. They postulated that the SF<sub>5</sub>-alkynes 68 might be ambiphilic, reacting as both an electrophile and a nucleophile. The regioselectivity of the reaction was controlled by the polarization of the triple bond induced by the SF<sub>5</sub> moiety, leading to the fully selective introduction of halides on the electron-deficient C<sub>β</sub> to the SF<sub>5</sub>. On the other hand, the stereoselectivity was determined by the reaction conditions. For the hydroiodination in the presence of a strong acid such as HI, the reaction was fully selective for the β,E-isomer 69, whereas in the presence of NaI and acetic acid as a soft acid, the reaction was fully selective for the β,Z-isomer 73. The two conditions sets were exemplified with many substrates and these methods were extended to the other halogens. Some difficulties were encountered with other halides, but these were solved by replacing HX solution with trifluoroacetic acid (TFA) with ammonium or phosphonium halide salts (with I-69, Br-70, and Cl-71) to improve solubility. Similarly, improved reactivity and selectivity were obtained by replacing NaX with ammonium or phosphonium halide salt (with I-73, Br-74, and Cl-75) in acetic acid. Fluorination was somewhat more challenging, but like Shibata we observed that TBAF solution without acid was efficient enough to form the β,Z-fluoroolefin 76, while the use of a pyridinium

BF₄ salt was used to access the β,E-fluoroolefin **72**. Two different reaction mechanisms have been proposed: in the first one (red arrows), the alkyne plays the role of the nucleophile and is protonated by the strong acid (HI or TFA); then, the intermediate carbocation **78** reacts with the halide on the most accessible face (on the opposite side to SF₅ due to steric hindrance) to form the β,E-SF₅-haloolefin **79**. In the second one (blue arrows), the alkyne plays the role of the electrophile and the halides (I, Br, Cl) perform a nucleophilic addition on the Cβ to generate a carbanion **80** which is protonated with the acetic acid, selectively yielding the β,Z-SF₅-haloolefin **81** (Scheme 18). These two mechanisms were validated by DFT calculations, indicating that the Z-stereoselectivity is solely due to the lower energy required to distort the reactant, whereas a stronger interaction between the reactants in the formation of E-alkenyl halides is due to a smaller overlap between their main occupied orbitals, ultimately leading to lower Pauli repulsion. This ambiphilic reactivity has also been exploited to perform dihalogenations of SF₅ alkynes with I₂, ICl, and Br₂ (**77**). The reaction with aryl-substituted SF₅-alkynes proved to be particularly efficient for these three reactants, whereas only the 1,2-dibromination gave the desired product with alkyl-SF₅-alkynes. A highly selective *cis*-dihalogenation was observed in all cases, which was even fully regioselective in the case of ICl with incorporation of the iodine on Cα and the chlorine on Cβ. The reaction mechanism was calculated for the 1,2-dibromination (green arrows) and confirmed that the reaction proceeds by the
<figure><img src="image_25.png" /><figcaption>**Scheme 18.** Regioselective and stereodivergent hydrohalogenation and dehalogenation of SF₅-alkynes.</figcaption></figure>

attack of the alkyne on Br⁺, with formation of a Cα-Br bond and a carbocation on Cβ (83), then the attack of the halide (Br⁻ from Br₃⁻) on the least hindered face of the carbocation at Cβ (on the opposite side of the SF₅), giving the cis-dibrominated product 84.

Finally, post-functionalization of β,ζ-iodo-SF₅-olefin 73 was developed for the first time (Scheme 19), including Pd-catalyzed Negishi, Sono-gashira, Stille and Suzuki cross-coupling reactions (85-88), Cu-catalyzed cyanation (89), Pd-catalyzed reduction or radical-initiated reduction (90-91), giving moderate to high yields. The reactivity of the β,ζ-iodo-SF₅-olefin 69 was also investigated but it proved to be much more sensitive to basic conditions, leading in some cases mainly to dehydrohalogenation or decomposition.

**5. Conclusion**

Several groups are actively working in the vibrant field of pentafluorosulfanyl chemistry. The keen interest in this motif is due to the unique properties of SF₅ such as geometry, volume, electronegativity, lipophilicity, and stability. Although usually considered as a “super CF₃”, the reactivity and selectivity conferred by the SF₅ substituent is fundamentally different. In this review, new synthetic achievements in the synthesis and use of SF₅-alkynes have been reported and we have shown that this small building block is highly versatile for the design of more complex molecules. Many challenges remain to be addressed and we along others are working hard to generalize the applications of SF₅ in various fields, including biological and medicinal chemistry, catalysis, and materials science.
<figure><img src="image_26.png" /><figcaption>**Scheme 19.** Functionalization of β,Z-iodo-SF₅-olefin.</figcaption></figure>

**Declaration of interests**

The authors do not work for, advise, own shares in, or receive funds from any organization that could benefit from this article, and have declared no affiliations other than their research organizations.

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