# Piritrexim

National Cancer Institute

## Source

National Cancer Institute. *Piritrexim*. NCI Thesaurus. Code C1031.

A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties.
Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate
metabolism and DNA synthesis and cell division. (NCI04)