# Mal de Meleda

INSERM

## Source

INSERM. (1999). Orphanet: an online rare disease and orphan drug data base. *Mal de Meleda*. ORPHA:87503

Mal de Meleda (MdM) is a diffuse palmoplantar keratoderma, initially reported in the Island of Meleda, characterized by symmetric palmoplantar hyperkeratosis that progressively extends to the dorsal surfaces of hands and feet (transgrediens). The disease can be associated to hyperhidrosis, lichenoid plaques and perioral erythema.