Rajendran, R. L., Gangadaran, P., Seo, C. H., Kwack, M. H., Oh, J. M., Lee, H. W., et al. (2020). Macrophage-Derived Extracellular Vesicle Promotes Hair Growth. *Cells* 9 (4), 856. doi:10.3390/cells9040856

Rana, S., Yue, S., Stadel, D., and Zöller, M. (2012). Toward Tailored Exosomes: the Exosomal Tetraspanin Web Contributes to Target Cell Selection. *Int. J. Biochem. Cel Biol.* 44 (9), 1574-1584. doi:10.1016/j.biocel.2012.06.018

Ricobono, D., Agay, D., Scherthan, H., Forcheron, F., Vivier, M., Ballester, B., et al. (2012). Application of Adipocyte-Derived Stem Cells in Treatment of Cutaneous Radiation Syndrome. *Health Phys.* 103 (2), 120-126. doi:10.1097/HP.0b013e318240595b

Rios, C., Jourdain, J.-R., and DiCarlo, A. L. (2017). Cellular Therapies for Treatment of Radiation Injury after a Mass Casualty Incident. *Radiat. Res.* 188 (2), 242-245. doi:10.1667/RR14835.1

Rocchi, C., and Emmerson, E. (2020). Mouth-Watering Results: Clinical Need, Current Approaches, and Future Directions for Salivary Gland Regeneration. *Trends Mol. Med.* 26 (7), 649-669. doi:10.1016/j.molmed.2020.03.009

Rong, X., Liu, J., Yao, X., Jiang, T., Wang, Y., and Xie, F. (2019). Human Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Alleviate Liver Fibrosis through the Wnt/β-Catenin Pathway. *Stem Cel Res Ther.* 10 (1), 98. doi:10.1186/s13287-019-1204-2

Rotolo, J., Stancevic, B., Zhang, J., Hua, G., Fuller, J., Yin, X., et al. (2012). Anti-ceramide Antibody Prevents the Radiation Gastrointestinal Syndrome in Mice. *J. Clin. Invest.* 122 (5), 1786-1790. doi:10.1172/JCI59920

Royo, F., Théry, C., Falcón-Pérez, J. M., Nieuwland, R., and Witwer, K. W. (2020). Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee. *Cells* 9 (9), 1955. doi:10.3390/cells9091955

Rühle, A., Xia, O., Perez, R. L., Trinh, T., Richter, W., Sarnowska, A., et al. (2018). The Radiation Resistance of Human Multipotent Mesenchymal Stromal Cells Is Independent of Their Tissue of Origin. *Int. J. Radiat. Oncology*Biology*Physics 100 (5), 1259-1269. doi:10.1016/j.ijrobp.2018.01.015

Sáez, T., de Vos, P., Kuipers, J., Sobrevia, L., and Faas, M. M. (2019). Exosomes Derived from Monocytes and from Endothelial Cells Mediate Monocyte and Endothelial Cell Activation under High D-Glucose Conditions. *Immunobiology* 224 (2), 325-333. doi:10.1016/j.imbio.2019.02.004

Sáez, T., de Vos, P., Kuipers, J., Sobrevia, L., and Faas, M. M. (2018). Fetoplacental Endothelial Exosomes Modulate High D -Glucose-Induced Endothelial Dysfunction. *Placenta* 66, 26-35. doi:10.1016/j.placenta.2018.04.010

Saha, S., Aranda, E., Hayakawa, Y., Bhanja, P., Atay, S., Brodin, N. P., et al. (2016). Macrophage-derived Extracellular Vesicle-Packaged WNTs Rescue Intestinal Stem Cells and Enhance Survival after Radiation Injury. *Nat. Commun.* 7, 13096. doi:10.1038/ncomms13096

Saha, S., Bhanja, P., Kabarriti, R., Liu, L., Alfieri, A. A., and Guha, C. (2011). Bone Marrow Stromal Cell Transplantation Mitigates Radiation-Induced Gastrointestinal Syndrome in Mice. *PLoS One* 6 (9), e24072. doi:10.1371/journal.pone.0024072

Schubart, A., Anderson, K., Mainolfi, N., Sellner, H., Ehara, T., Adams, C. M., et al. (2019). Small-molecule Factor B Inhibitor for the Treatment of Complement-Mediated Diseases. *Proc. Natl. Acad. Sci. USA* 116 (16), 7926-7931. doi:10.1073/pnas.1820892116

Singh, V., Fatanmi, O., Santiago, P., Simas, M., Hanlon, B., Garcia, M., et al. (2018). Current Status of Radiation Countermeasures for Acute Radiation Syndrome under Advanced Development. *J. Radiat. Cancer Res.* 9 (1), 13. doi:10.4103/jrcr.jrcr_3_18

Singh, S., Kloss, F. R., Brunauer, R., Schimke, M., Jarnig, A., Greiderer-Kleinlercher, B., et al. (2012). Mesenchymal stem cells show radioresistance in vivo. *J. Cell. Mol. Med.* 16 (4), 877-887. doi:10.1111/j.1582-4934.2011.01383.x

Singh, V. K., and Seed, T. M. (2020). BIO 300: a Promising Radiation Countermeasure under Advanced Development for Acute Radiation Syndrome and the Delayed Effects of Acute Radiation Exposure. *Expert Opin. Investig. Drugs* 29 (5), 429-441. doi:10.1080/13543784.2020.1757648

Soria, B., Martin-Montalvo, A., Aguilera, Y., Mellado-Damas, N., López-Beas, J., Herrera-Herrera, I., et al. (2019). Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy. *Front. Cel. Neurosci.* 13, 204. doi:10.3389/fncel.2019.00204

Stevens, T., Phan, S., Frid, M. G., Alvarez, D., Herzog, E., and Stenmark, K. R. (2008). Lung Vascular Cell Heterogeneity: Endothelium, Smooth Muscle, and

Fibroblasts. *Proc. Am. Thorac. Soc.* 5 (7), 783-791. doi:10.1513/pats.200803-027HR

Stewart, F. A., Seemann, I., Hoving, S., and Russell, N. S. (2013). Understanding Radiation-Induced Cardiovascular Damage and Strategies for Intervention. *Clin. Oncol.* 25 (10), 617-624. doi:10.1016/j.clon.2013.06.012

Taheri, B., Soleimani, M., Fekri Aval, S., Esmaeili, E., Bazi, Z., and Zarghami, N. (2019). Induced Pluripotent Stem Cell-derived Extracellular Vesicles: A Novel Approach for Cell-free Regenerative Medicine. *J. Cel Physiol* 234 (6), 8455-8464. doi:10.1002/jcp.27775

Takeuchi, R., Katagiri, W., Endo, S., and Kobayashi, T. (2019). Exosomes from Conditioned Media of Bone Marrow-Derived Mesenchymal Stem Cells Promote Bone Regeneration by Enhancing Angiogenesis. *PLoS One* 14 (11), e0225472. doi:10.1371/journal.pone.0225472

Tan, C., Lai, R., Wong, W., Dan, Y., Lim, S.-K., and Ho, H. (2014). Mesenchymal Stem Cell-Derived Exosomes Promote Hepatic Regeneration in Drug-Induced Liver Injury Models. *Stem Cel Res. Ther.* 5 (3), 76. doi:10.1186/s00465

Thery, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., et al. (2018). Minimal Information for Studies of Extracellular Vesicles 2018 (MISEV2018): a Position Statement of the International Society for Extracellular Vesicles and Update of the MISEV2014 Guidelines. *J. Extracell Vesicles* 7 (1), 1535750. doi:10.1080/20013078.2018.1535750

Tomasoni, S., Longaretti, L., Rota, C., Morigi, M., Conti, S., Gotti, E., et al. (2013). Transfer of Growth Factor Receptor mRNA via Exosomes Unravels the Regenerative Effect of Mesenchymal Stem Cells. *Stem Cell Development* 22 (5), 772-780. doi:10.1089/scd.2012.0266

Tsiapalis, D., and O'Driscoll, L. (2020). Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications. *Cells* 9 (4), 991. doi:10.3390/cells9040991

Uribe-Etxebarria, V., Luzuriaga, J., Luzuriaga, J., García-Gallastegui, P., Agliano, A., Unda, F., et al. (2017). Notch/Wnt Cross-Signalling Regulates Stemness of Dental Pulp Stem Cells through Expression of Neural Crest and Core Pluripotency Factors. *ECM* 34, 249-270. doi:10.22203/eCM.v03a416

Vakili, S., Ahooyi, T. M., Yarandi, S. S., Donadoni, M., Rappaport, J., and Sariyer, I. K. (2020). Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials. *Brain Sci.* 10 (7), 424. doi:10.3390/brainsci10070424

van Balkom, B. W. M., Eisele, A. S., Pegtel, D. M., Bervoets, S., and Verhaar, M. C. (2015). Quantitative and Qualitative Analysis of Small RNAs in Human Endothelial Cells and Exosomes Provides Insights into Localized RNA Processing, Degradation and Sorting. *J. Extracellular Vesicles* 4, 26760. doi:10.3402/jev.v4.26760

Van Deun, J., Mestdagh, P., Mestdagh, P., Agostinis, P., Akay, Ö., Anand, S., et al. (2017). EV-TRACK: Transparent Reporting and Centralizing Knowledge in Extracellular Vesicle Research. *Nat. Methods* 14 (3), 228-232. doi:10.1038/nnmeth.4185

Viñas, J. L., Spence, M., Gutsol, A., Knoll, W., Burger, D., Zimpelmann, J., et al. (2018). Receptor-Ligand Interaction Mediates Targeting of Endothelial Colony Forming Cell-Derived Exosomes to the Kidney after Ischemic Injury. *Sci. Rep.* 8 (1), 16320. doi:10.1038/s41598-018-34557-7

Viswanathan, S., Shi, Y., Galipeau, J., Krampera, M., Leblanc, K., Martin, I., et al. (2019). Mesenchymal Stem versus Stromal Cells: International Society for Cell & Gene Therapy (ISCT) Mesenchymal Stromal Cell Committee Position Statement on Nomenclature. *Cytotherapy* 21 (10), 1019-1024. doi:10.1016/j.jcyt.2019.08.002

Vrijsen, K. R., Maring, J. A., Chamuleau, S. A. J., Verhage, V., Mol, E. A., Deddens, J. C., et al. (2016). Exosomes from Cardiomyocyte Progenitor Cells and Mesenchymal Stem Cells Stimulate Angiogenesis via EMMPRIN. *Adv. Healthc. Mater.* 5 (19), 2555-2565. doi:10.1002/adhm.201600308

Walasek, M. A., van Os, R., and de Haan, G. (2012). Hematopoietic Stem Cell Expansion: Challenges and Opportunities. *Ann. N. Y Acad. Sci.* 1266, 138-150. doi:10.1111/j.1749-6632.2012.06549.x

Wallis, R., Mizen, H., and Bishop, C. L. (2020). The Bright and Dark Side of Extracellular Vesicles in the Senescence-Associated Secretory Phenotype. *Mech. Ageing Development* 189, 111263. doi:10.1016/j.mad.2020.111263
Rajendran, R. L., Gangadaran, P., Seo, C. H., Kwack, M. H., Oh, J. M., Lee, H. W., et al. (2020). Macrophage-Derived Extracellular Vesicle Promotes Hair Growth. *Cells* 9 (4), 856. doi:10.3390/cells9040856

Rana, S., Yue, S., Stadel, D., and Zöller, M. (2012). Toward Tailored Exosomes: the Exosomal Tetraspanin Web Contributes to Target Cell Selection. *Int. J. Biochem. Cel Biol.* 44 (9), 1574-1584. doi:10.1016/j.biocel.2012.06.018

Ricobono, D., Agay, D., Scherthan, H., Forcheron, F., Vivier, M., Ballester, B., et al. (2012). Application of Adipocyte-Derived Stem Cells in Treatment of Cutaneous Radiation Syndrome. *Health Phys.* 103 (2), 120-126. doi:10.1097/HP.0b013e318240595b

Rios, C., Jourdain, J.-R., and DiCarlo, A. L. (2017). Cellular Therapies for Treatment of Radiation Injury after a Mass Casualty Incident. *Radiat. Res.* 188 (2), 242-245. doi:10.1667/RR14835.1

Rocchi, C., and Emmerson, E. (2020). Mouth-Watering Results: Clinical Need, Current Approaches, and Future Directions for Salivary Gland Regeneration. *Trends Mol. Med.* 26 (7), 649-669. doi:10.1016/j.molmed.2020.03.009

Rong, X., Liu, J., Yao, X., Jiang, T., Wang, Y., and Xie, F. (2019). Human Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Alleviate Liver Fibrosis through the Wnt/β-Catenin Pathway. *Stem Cel Res Ther.* 10 (1), 98. doi:10.1186/s13287-019-1204-2

Rotolo, J., Stancevic, B., Zhang, J., Hua, G., Fuller, J., Yin, X., et al. (2012). Anti-ceramide Antibody Prevents the Radiation Gastrointestinal Syndrome in Mice. *J. Clin. Invest.* 122 (5), 1786-1790. doi:10.1172/JCI59920

Royo, F., Théry, C., Falcón-Pérez, J. M., Nieuwland, R., and Witwer, K. W. (2020). Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee. *Cells* 9 (9), 1955. doi:10.3390/cells9091955

Rühle, A., Xia, O., Perez, R. L., Trinh, T., Richter, W., Sarnowska, A., et al. (2018). The Radiation Resistance of Human Multipotent Mesenchymal Stromal Cells Is Independent of Their Tissue of Origin. *Int. J. Radiat. Oncology*Biology*Physics 100 (5), 1259-1269. doi:10.1016/j.ijrobp.2018.01.015

Sáez, T., de Vos, P., Kuipers, J., Sobrevia, L., and Faas, M. M. (2019). Exosomes Derived from Monocytes and from Endothelial Cells Mediate Monocyte and Endothelial Cell Activation under High D-Glucose Conditions. *Immunobiology* 224 (2), 325-333. doi:10.1016/j.imbio.2019.02.004

Sáez, T., de Vos, P., Kuipers, J., Sobrevia, L., and Faas, M. M. (2018). Fetoplacental Endothelial Exosomes Modulate High D -Glucose-Induced Endothelial Dysfunction. *Placenta* 66, 26-35. doi:10.1016/j.placenta.2018.04.010

Saha, S., Aranda, E., Hayakawa, Y., Bhanja, P., Atay, S., Brodin, N. P., et al. (2016). Macrophage-derived Extracellular Vesicle-Packaged WNTs Rescue Intestinal Stem Cells and Enhance Survival after Radiation Injury. *Nat. Commun.* 7, 13096. doi:10.1038/ncomms13096

Saha, S., Bhanja, P., Kabarriti, R., Liu, L., Alfieri, A. A., and Guha, C. (2011). Bone Marrow Stromal Cell Transplantation Mitigates Radiation-Induced Gastrointestinal Syndrome in Mice. *PLoS One* 6 (9), e24072. doi:10.1371/journal.pone.0024072

Schubart, A., Anderson, K., Mainolfi, N., Sellner, H., Ehara, T., Adams, C. M., et al. (2019). Small-molecule Factor B Inhibitor for the Treatment of Complement-Mediated Diseases. *Proc. Natl. Acad. Sci. USA* 116 (16), 7926-7931. doi:10.1073/pnas.1820892116

Singh, V., Fatanmi, O., Santiago, P., Simas, M., Hanlon, B., Garcia, M., et al. (2018). Current Status of Radiation Countermeasures for Acute Radiation Syndrome under Advanced Development. *J. Radiat. Cancer Res.* 9 (1), 13. doi:10.4103/jrcr.jrcr_3_18

Singh, S., Kloss, F. R., Brunauer, R., Schimke, M., Jarnig, A., Greiderer-Kleinlercher, B., et al. (2012). Mesenchymal stem cells show radioresistance in vivo. *J. Cell. Mol. Med.* 16 (4), 877-887. doi:10.1111/j.1582-4934.2011.01383.x

Singh, V. K., and Seed, T. M. (2020). BIO 300: a Promising Radiation Countermeasure under Advanced Development for Acute Radiation Syndrome and the Delayed Effects of Acute Radiation Exposure. *Expert Opin. Investig. Drugs* 29 (5), 429-441. doi:10.1080/13543784.2020.1757648

Soria, B., Martin-Montalvo, A., Aguilera, Y., Mellado-Damas, N., López-Beas, J., Herrera-Herrera, I., et al. (2019). Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy. *Front. Cel. Neurosci.* 13, 204. doi:10.3389/fncel.2019.00204

Stevens, T., Phan, S., Frid, M. G., Alvarez, D., Herzog, E., and Stenmark, K. R. (2008). Lung Vascular Cell Heterogeneity: Endothelium, Smooth Muscle, and

Fibroblasts. *Proc. Am. Thorac. Soc.* 5 (7), 783-791. doi:10.1513/pats.200803-027HR

Stewart, F. A., Seemann, I., Hoving, S., and Russell, N. S. (2013). Understanding Radiation-Induced Cardiovascular Damage and Strategies for Intervention. *Clin. Oncol.* 25 (10), 617-624. doi:10.1016/j.clon.2013.06.012

Taheri, B., Soleimani, M., Fekri Aval, S., Esmaeili, E., Bazi, Z., and Zarghami, N. (2019). Induced Pluripotent Stem Cell-derived Extracellular Vesicles: A Novel Approach for Cell-free Regenerative Medicine. *J. Cel Physiol* 234 (6), 8455-8464. doi:10.1002/jcp.27775

Takeuchi, R., Katagiri, W., Endo, S., and Kobayashi, T. (2019). Exosomes from Conditioned Media of Bone Marrow-Derived Mesenchymal Stem Cells Promote Bone Regeneration by Enhancing Angiogenesis. *PLoS One* 14 (11), e0225472. doi:10.1371/journal.pone.0225472

Tan, C., Lai, R., Wong, W., Dan, Y., Lim, S.-K., and Ho, H. (2014). Mesenchymal Stem Cell-Derived Exosomes Promote Hepatic Regeneration in Drug-Induced Liver Injury Models. *Stem Cel Res. Ther.* 5 (3), 76. doi:10.1186/s00465

Thery, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., et al. (2018). Minimal Information for Studies of Extracellular Vesicles 2018 (MISEV2018): a Position Statement of the International Society for Extracellular Vesicles and Update of the MISEV2014 Guidelines. *J. Extracell Vesicles* 7 (1), 1535750. doi:10.1080/20013078.2018.1535750

Tomasoni, S., Longaretti, L., Rota, C., Morigi, M., Conti, S., Gotti, E., et al. (2013). Transfer of Growth Factor Receptor mRNA via Exosomes Unravels the Regenerative Effect of Mesenchymal Stem Cells. *Stem Cell Development* 22 (5), 772-780. doi:10.1089/scd.2012.0266

Tsiapalis, D., and O'Driscoll, L. (2020). Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications. *Cells* 9 (4), 991. doi:10.3390/cells9040991

Uribe-Etxebarria, V., Luzuriaga, J., Luzuriaga, J., García-Gallastegui, P., Agliano, A., Unda, F., et al. (2017). Notch/Wnt Cross-Signalling Regulates Stemness of Dental Pulp Stem Cells through Expression of Neural Crest and Core Pluripotency Factors. *ECM* 34, 249-270. doi:10.22203/eCM.v03a416

Vakili, S., Ahooyi, T. M., Yarandi, S. S., Donadoni, M., Rappaport, J., and Sariyer, I. K. (2020). Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials. *Brain Sci.* 10 (7), 424. doi:10.3390/brainsci10070424

van Balkom, B. W. M., Eisele, A. S., Pegtel, D. M., Bervoets, S., and Verhaar, M. C. (2015). Quantitative and Qualitative Analysis of Small RNAs in Human Endothelial Cells and Exosomes Provides Insights into Localized RNA Processing, Degradation and Sorting. *J. Extracellular Vesicles* 4, 26760. doi:10.3402/jev.v4.26760

Van Deun, J., Mestdagh, P., Mestdagh, P., Agostinis, P., Akay, Ö., Anand, S., et al. (2017). EV-TRACK: Transparent Reporting and Centralizing Knowledge in Extracellular Vesicle Research. *Nat. Methods* 14 (3), 228-232. doi:10.1038/nnmeth.4185

Viñas, J. L., Spence, M., Gutsol, A., Knoll, W., Burger, D., Zimpelmann, J., et al. (2018). Receptor-Ligand Interaction Mediates Targeting of Endothelial Colony Forming Cell-Derived Exosomes to the Kidney after Ischemic Injury. *Sci. Rep.* 8 (1), 16320. doi:10.1038/s41598-018-34557-7

Viswanathan, S., Shi, Y., Galipeau, J., Krampera, M., Leblanc, K., Martin, I., et al. (2019). Mesenchymal Stem versus Stromal Cells: International Society for Cell & Gene Therapy (ISCT) Mesenchymal Stromal Cell Committee Position Statement on Nomenclature. *Cytotherapy* 21 (10), 1019-1024. doi:10.1016/j.jcyt.2019.08.002

Vrijsen, K. R., Maring, J. A., Chamuleau, S. A. J., Verhage, V., Mol, E. A., Deddens, J. C., et al. (2016). Exosomes from Cardiomyocyte Progenitor Cells and Mesenchymal Stem Cells Stimulate Angiogenesis via EMMPRIN. *Adv. Healthc. Mater.* 5 (19), 2555-2565. doi:10.1002/adhm.201600308

Walasek, M. A., van Os, R., and de Haan, G. (2012). Hematopoietic Stem Cell Expansion: Challenges and Opportunities. *Ann. N. Y Acad. Sci.* 1266, 138-150. doi:10.1111/j.1749-6632.2012.06549.x

Wallis, R., Mizen, H., and Bishop, C. L. (2020). The Bright and Dark Side of Extracellular Vesicles in the Senescence-Associated Secretory Phenotype. *Mech. Ageing Development* 189, 111263. doi:10.1016/j.mad.2020.111263
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Yan, W., Li, T., Yin, T., Hou, Z., Qu, K., Wang, N., et al. (2020). M2 Macrophage-Derived Exosomes Promote the C-KIT Phenotype of Vascular Smooth Muscle Cells during Vascular Tissue Repair after Intravascular Stent Implantation. *Theranostics* 10 (23), 10712–10728. doi:10.7150/thno.46143

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Zhang, Y., Jiang, X., and Ren, L. (2019). Optimization of the Adipose-Derived Mesenchymal Stem Cell Delivery Time for Radiation-Induced Lung Fibrosis Treatment in Rats. *Sci. Rep.* 9 (1), 5589. doi:10.1038/s41598-019-41576-5

Zhang, Y., Qin, Y., Chopp, M., Li, C., Kemper, A., Liu, X., et al. (2020b). Ischemic Cerebral Endothelial Cell-Derived Exosomes Promote Axonal Growth. *Stroke* 51 (12), 3701–3712. doi:10.1161/STROKEAHA.120.031728

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Zhou, Y., Li, P., Goodwin, A. J., Cook, J. A., Halushka, P. V., Chang, E., et al. (2018). Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis. *Mol. Ther.* 26 (5), 1375–1384. doi:10.1016/j.ymthe.2018.02.020

Ziegler, V., Henninger, C., Simiantonakis, I., Buchholzer, M., Ahmadian, M. R., Budach, W., et al. (2017). Rho Inhibition by Lovastatin Affects Apoptosis and DSB Repair of Primary Human Lung Cells In Vitro and Lung Tissue In Vivo Following Fractionated Irradiation. *Cel Death Dis.* 8 (8), e2978. doi:10.1038/ cddis.2017.372

Zou, L., Ma, X., Lin, S., Wu, B., Chen, Y., and Peng, C. (2019). Bone Marrow Mesenchymal Stem Cell-derived E-xosomes P-rotect against M-yocardial I-nfarction by P-romoting A-utophagy. *Exp. Ther. Med.* 18 (4), 2574–2582. doi:10.3892/etm.2019.7874

Zuo, R., Liu, M., Wang, Y., Li, J., Wang, W., Wu, J., et al. (2019). BM-MSC-derived Exosomes Alleviate Radiation-Induced Bone Loss by Restoring the Function of Recipient BM-MSCs and Activating Wnt/β-Catenin Signaling. *Stem Cel Res Ther.* 10 (1), 30. doi:10.1186/s13287-018-1121-9

**Conflict of Interest:** The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2021 Nanduri, Duddempudi, Yang, Tamarat and Guha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Ziegler, V., Henninger, C., Simiantonakis, I., Buchholzer, M., Ahmadian, M. R., Budach, W., et al. (2017). Rho Inhibition by Lovastatin Affects Apoptosis and DSB Repair of Primary Human Lung Cells In Vitro and Lung Tissue In Vivo Following Fractionated Irradiation. *Cel Death Dis.* 8 (8), e2978. doi:10.1038/cddis.2017.372

Zou, L., Ma, X., Lin, S., Wu, B., Chen, Y., and Peng, C. (2019). Bone Marrow Mesenchymal Stem Cell-derived E-xosomes P-rotect against M-yocardial I-nfarction by P-romoting A-utophagy. *Exp. Ther. Med.* 18 (4), 2574–2582. doi:10.3892/etm.2019.7874

Zuo, R., Liu, M., Wang, Y., Li, J., Wang, W., Wu, J., et al. (2019). BM-MSC-derived Exosomes Alleviate Radiation-Induced Bone Loss by Restoring the Function of Recipient BM-MSCs and Activating Wnt/β-Catenin Signaling. *Stem Cel Res Ther.* 10 (1), 30. doi:10.1186/s13287-018-1121-9

**Conflict of Interest:** The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2021 Nanduri, Duddempudi, Yang, Tamarat and Guha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
GLOSSARY

**ARS** Acute radiation syndrome

**BMASC** Bone marrow-derived adherent stromal cell

**BMMSC** Bone marrow mesenchymal stem cells

**BMM** Bone marrow macrophage

**BV/TV** Bone volume fraction

**CCL2** Chemokine (C-C motif) ligand 2

**DAMP** Damage-associated molecular patterns

**DEARE** Delayed effects of acute radiation exposure

**DSB** double-strand breaks

**DSS** Dextran sulfate sodium

**EC** Endothelial cell

**EC-EVs** Endothelial cell-extracellular vesicles

**ECFC** Endothelial colony-forming cells

**ERK1/2** Extracellular signal-regulated protein kinase

**EM** Electron microscopy

**EMMPRIN** Extracellular matrix metalloproteinase inducer

**EV** Extracellular vesicle

**FDA** Food and drug administration

**G-CSF** Granulocyte colony-stimulating factor

**GM-CSF** Granulocyte-macrophage colony-stimulating factor

**Gy** unit of radiation

**Gray** = 100 rads

**GMP** Good manufacturing practice

**HSCs** Hematopoietic stem cells

**HUVEC** Human umbilical cord vein endothelial cells

**ICAM1** Intercellular adhesion molecule 1

**iPSC** induced pluripotent stem cells

**IL** Interleukin

**ISC** Intestinal Stem Cells

**ISEV** International society of extracellular vesicles

**Lgr5** Leucine-rich repeat-containing G-protein coupled receptor 5

**MAPK** Mitogen-activated protein kinase

**Mφs** Macrophages

**MCM** Medical countermeasure

**MISEV** Minimal information for studies on extracellular vesicles

**MM6** Mono-Mac-6

**MSC** Mesenchymal Stem Cells

**NF-κB** nuclear factor kappa-light-chain-enhancer of activated B cells

**NIH** National Institute of Health

**PTEN** Phosphatase and Tensin Homolog

**RIBE** Radiation-induced bystander effect

**RILD** Radiation-induced liver disease

**ROS** reactive oxygen species

**SASP** Senescence-associated secreted phenotype

**SH-SY5Y** human neuroblastoma cells

**SOD** Super oxide dismutase

**SSB** Single strand breaks

**TCF/LEF** T-cell factor/lymphoid enhancer factor

**TNF-α** Tumor necrosis factor-alpha

**TSG101** Tumor susceptibility gene 101

**Plau/uPA** urokinase-type plasminogen activator

**VCAM1** Vascular cell adhesion molecule 1

**VE-cadherin** Vascular endothelial-cadherin

**WBI** Whole-body irradiation
GLOSSARY

**ARS** Acute radiation syndrome

**BMASC** Bone marrow-derived adherent stromal cell

**BMMSC** Bone marrow mesenchymal stem cells

**BMM** Bone marrow macrophage

**BV/TV** Bone volume fraction

**CCL2** Chemokine (C-C motif) ligand 2

**DAMP** Damage-associated molecular patterns

**DEARE** Delayed effects of acute radiation exposure

**DSB** double-strand breaks

**DSS** Dextran sulfate sodium

**EC** Endothelial cell

**EC-EVs** Endothelial cell-extracellular vesicles

**ECFC** Endothelial colony-forming cells

**ERK1/2** Extracellular signal-regulated protein kinase

**EM** Electron microscopy

**EMMPRIN** Extracellular matrix metalloproteinase inducer

**EV** Extracellular vesicle

**FDA** Food and drug administration

**G-CSF** Granulocyte colony-stimulating factor

**GM-CSF** Granulocyte-macrophage colony-stimulating factor

**Gy** unit of radiation

**Gray** = 100 rads

**GMP** Good manufacturing practice

**HSCs** Hematopoietic stem cells

**HUVEC** Human umbilical cord vein endothelial cells

**ICAM1** Intercellular adhesion molecule 1

**iPSC** induced pluripotent stem cells

**IL** Interleukin

**ISC** Intestinal Stem Cells

**ISEV** International society of extracellular vesicles

**Lgr5** Leucine-rich repeat-containing G-protein coupled receptor 5

**MAPK** Mitogen-activated protein kinase

**Mφs** Macrophages

**MCM** Medical countermeasure

**MISEV** Minimal information for studies on extracellular vesicles

**MM6** Mono-Mac-6

**MSC** Mesenchymal Stem Cells

**NF-κB** nuclear factor kappa-light-chain-enhancer of activated B cells

**NIH** National Institute of Health

**PTEN** Phosphatase and Tensin Homolog

**RIBE** Radiation-induced bystander effect

**RILD** Radiation-induced liver disease

**ROS** reactive oxygen species

**SASP** Senescence-associated secreted phenotype

**SH-SY5Y** human neuroblastoma cells

**SOD** Super oxide dismutase

**SSB** Single strand breaks

**TCF/LEF** T-cell factor/lymphoid enhancer factor

**TNF-α** Tumor necrosis factor-alpha

**TSG101** Tumor susceptibility gene 101

**Plau/uPA** urokinase-type plasminogen activator

**VCAM1** Vascular cell adhesion molecule 1

**VE-cadherin** Vascular endothelial-cadherin

**WBI** Whole-body irradiation