# RIPK1 wt Allele

National Cancer Institute

## Source

National Cancer Institute. *RIPK1 wt Allele*. NCI Thesaurus. Code C51308.

Human RIPK1 wild-type allele is located in the vicinity of 6p25.2 and is approximately 37 kb in length. This allele, which encodes receptor-interacting serine/threonine-protein kinase 1 protein, is involved in positive regulation of apoptosis and activation of the transcription factor NF-kappa-B. The RIPK1 gene is down-regulated in mantle cell lymphomas.