# Expert Consensus on Clinical Decision Making in the Disease Trajectory of Oropharyngeal Dysphagia in Adults: An International Delphi Study

Renée Speyer, Mathieu Balaguer, Emmanuelle Cugy, Clémence Devoucoux, Sylvain Morinière, Gaëlle Soriano, Eric Vérin, Virginie Woisard

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## To cite this version:

Renée Speyer, Mathieu Balaguer, Emmanuelle Cugy, Clémence Devoucoux, Sylvain Morinière, et al. Expert Consensus on Clinical Decision Making in the Disease Trajectory of Oropharyngeal Dysphagia in Adults: An International Delphi Study. Journal of Clinical Medicine, 2023, 12 (20), pp.6572-10.3390/jcm12206572. [https://doi.org/10.3390/jcm12206572](https://doi.org/10.3390/jcm12206572)

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Article

# Expert Consensus on Clinical Decision Making in the Disease Trajectory of Oropharyngeal Dysphagia in Adults: An International Delphi Study

Renée Speyer ¹,²,³,* ID, Mathieu Balaguer ⁴,⁵ ID, Emmanuelle Cugy ⁶,⁷, Clémence Devoucoux ⁵,⁸ ID,
Sylvain Morinière ⁹,¹⁰ ID, Gaëlle Soriano ¹¹, Eric Vérin ¹²,¹³ and Virginie Woisard ⁵,⁸,¹⁴,¹⁵

1 Department Special Needs Education, University of Oslo, 0318 Oslo, Norway

2 Curtin School of Allied Health, Faculty of Health Sciences, Curtin University, Perth 6102, Australia

3 Department of Otorhinolaryngology and Head and Neck Surgery, Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands

4 Institut de Recherche en Informatique de Toulouse, Centre national de la Recherche Scientifique, University of Toulouse, 31062 Toulouse, France; mathieu.balaguer@irit.fr

5 Department of Medicine, Maieutic and Allied Health, Faculty of Health, University of Toulouse, Paul Sabatier Toulouse III, 133 Route de Narbonne, 31062 Toulouse, France; devoucoux.c@chu-toulouse.fr (C.D.); woisard.virginie@iuct-oncopole.fr (V.W.)

6 Department of Physical and Rehabilitation Medicine, Arcachon Hospital, 33260 La Teste de Buch, France; emmanuelle.cugy@chu-bordeaux.fr

7 Department of Physical and Rehabilitation Medicine, Tastet Girard Hospital, CEDEX, 33076 Bordeaux, France

8 Department of Otorhinolaryngology and Head and Neck Surgery, Larrey Hospital, University Hospital of Toulouse, 31400 Toulouse, France

9 Department of Otorhinolaryngology and Head and Neck Surgery, Tours University Hospital, 37000 Tours, France; sylvain.moriniere@univ-tours.fr

10 Otorhinolaryngology Department, University François Rabelais of Tours, 10 Bd Tonnellé, 37032 Tours, France

11 Department of Geriatrics, Toulouse University Hospital, 31000 Toulouse, France; soriano.g@chu-toulouse.fr

12 GRHVN UR 3830, Research Group on Ventilatory and Neurological Handicap, Laboratoire de Chirurgie Experimentale, University of Rouen Normandie, 76000 Rouen, France; eric.verin@chu-rouen.fr

13 Department of Pulmonary Rehabilitation, CHU Rouen, UR 3830, Normandie University, UNIROUEN, 76000 Rouen, France

14 Neuro-Psycho-Linguistic Lab UR 4156, University of Toulouse, Jean Jaurès Toulouse II, 5, Allée Antonio Machado, CEDEX 9, 31058 Toulouse, France

15 Department of Supportive Care, Cancer University Institute of Toulouse Oncopole, 1 avenue Irène Joliot-Curie, CEDEX 9, 31059 Toulouse, France

* Correspondence: renee.speijer@isp.uio.no

<figure><img src="image_1.png" /></figure>

check for
updates

**Citation:** Speyer, R.; Balaguer, M.; Cugy, E.; Devoucoux, C.; Morinière, S.; Soriano, G.; Vérin, E.; Woisard, V. Expert Consensus on Clinical Decision Making in the Disease Trajectory of Oropharyngeal Dysphagia in Adults: An International Delphi Study. *J. Clin. Med.* **2023**, *12*, 6572. https://doi.org/10.3390/jcm12206572

Academic Editor: Lee Michael Akst

Received: 7 September 2023

Revised: 11 October 2023

Accepted: 13 October 2023

Published: 17 October 2023

<figure><img src="image_2.png" /></figure>

**Copyright:** © 2023 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/).

**Abstract:** To date, no consensus exists on the complex clinical decision-making processes involved in oropharyngeal dysphagia, or swallowing disorders. This study aimed to develop an international consensus on a clinical decision tree for the disease trajectory of oropharyngeal dysphagia in adults, taking into account physiological impairments of swallowing, risk factors for the development of complications from oropharyngeal dysphagia, and prognostic factors for treatment outcomes. Using the Delphi technique, consensus was achieved among dysphagia experts across 31 countries, resulting in a total of 10 physiological impairments, 23 risk factors and 21 prognostic factors identified as relevant factors in the clinical decision-making process. Factors most contributing to the severity of oropharyngeal dysphagia were 'Aspiration', 'Incomplete ejection or failure to eject aspirated materials from the airways', 'Weak or absent cough', 'Choking' and 'Sensory deficits in the oropharynx'. To connect the existing theoretical framework to clinical practice, future research will develop the current findings by corroborating the domains based on relevant factors for clinical decision making and those that contribute to the severity of oropharyngeal dysphagia.

**Keywords:** deglutition; swallowing disorders; survey; questionnaire; framework; prognosis; risk; impairment; severity
Article

# Expert Consensus on Clinical Decision Making in the Disease Trajectory of Oropharyngeal Dysphagia in Adults: An International Delphi Study

Renée Speyer ¹,²,³,* ID, Mathieu Balaguer ⁴,⁵ ID, Emmanuelle Cugy ⁶,⁷, Clémence Devoucoux ⁵,⁸ ID, Sylvain Morinière ⁹,¹⁰ ID, Gaëlle Soriano ¹¹, Eric Vérin ¹²,¹³ and Virginie Woisard ⁵,⁸,¹⁴,¹⁵

1 Department Special Needs Education, University of Oslo, 0318 Oslo, Norway

2 Curtin School of Allied Health, Faculty of Health Sciences, Curtin University, Perth 6102, Australia

3 Department of Otorhinolaryngology and Head and Neck Surgery, Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands

4 Institut de Recherche en Informatique de Toulouse, Centre national de la Recherche Scientifique, University of Toulouse, 31062 Toulouse, France; mathieu.balaguer@irit.fr

5 Department of Medicine, Maieutic and Allied Health, Faculty of Health, University of Toulouse, Paul Sabatier Toulouse III, 133 Route de Narbonne, 31062 Toulouse, France; devoucoux.c@chu-toulouse.fr (C.D.); woisard.virginie@iuct-oncopole.fr (V.W.)

6 Department of Physical and Rehabilitation Medicine, Arcachon Hospital, 33260 La Teste de Buch, France; emmanuelle.cugy@chu-bordeaux.fr

7 Department of Physical and Rehabilitation Medicine, Tastet Girard Hospital, CEDEX, 33076 Bordeaux, France

8 Department of Otorhinolaryngology and Head and Neck Surgery, Larrey Hospital, University Hospital of Toulouse, 31400 Toulouse, France

9 Department of Otorhinolaryngology and Head and Neck Surgery, Tours University Hospital, 37000 Tours, France; sylvain.moriniere@univ-tours.fr

10 Otorhinolaryngology Department, University François Rabelais of Tours, 10 Bd Tonnellé, 37032 Tours, France

11 Department of Geriatrics, Toulouse University Hospital, 31000 Toulouse, France; soriano.g@chu-toulouse.fr

12 GRHVN UR 3830, Research Group on Ventilatory and Neurological Handicap, Laboratoire de Chirurgie Experimentale, University of Rouen Normandie, 76000 Rouen, France; eric.verin@chu-rouen.fr

13 Department of Pulmonary Rehabilitation, CHU Rouen, UR 3830, Normandie University, UNIROUEN, 76000 Rouen, France

14 Neuro-Psycho-Linguistic Lab UR 4156, University of Toulouse, Jean Jaurès Toulouse II, 5, Allée Antonio Machado, CEDEX 9, 31058 Toulouse, France

15 Department of Supportive Care, Cancer University Institute of Toulouse Oncopole, 1 avenue Irène Joliot-Curie, CEDEX 9, 31059 Toulouse, France

* Correspondence: renee.speijer@isp.uio.no

<figure><img src="image_3.png" /></figure>

check for
updates

**Citation:** Speyer, R.; Balaguer, M.; Cugy, E.; Devoucoux, C.; Morinière, S.; Soriano, G.; Vérin, E.; Woisard, V. Expert Consensus on Clinical Decision Making in the Disease Trajectory of Oropharyngeal Dysphagia in Adults: An International Delphi Study. *J. Clin. Med.* **2023**, *12*, 6572. https://doi.org/10.3390/jcm12206572

Academic Editor: Lee Michael Akst

Received: 7 September 2023

Revised: 11 October 2023

Accepted: 13 October 2023

Published: 17 October 2023

<figure><img src="image_4.png" /></figure>

**Copyright:** © 2023 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/).

**Abstract:** To date, no consensus exists on the complex clinical decision-making processes involved in oropharyngeal dysphagia, or swallowing disorders. This study aimed to develop an international consensus on a clinical decision tree for the disease trajectory of oropharyngeal dysphagia in adults, taking into account physiological impairments of swallowing, risk factors for the development of complications from oropharyngeal dysphagia, and prognostic factors for treatment outcomes. Using the Delphi technique, consensus was achieved among dysphagia experts across 31 countries, resulting in a total of 10 physiological impairments, 23 risk factors and 21 prognostic factors identified as relevant factors in the clinical decision-making process. Factors most contributing to the severity of oropharyngeal dysphagia were 'Aspiration', 'Incomplete ejection or failure to eject aspirated materials from the airways', 'Weak or absent cough', 'Choking' and 'Sensory deficits in the oropharynx'. To connect the existing theoretical framework to clinical practice, future research will develop the current findings by corroborating the domains based on relevant factors for clinical decision making and those that contribute to the severity of oropharyngeal dysphagia.

**Keywords:** deglutition; swallowing disorders; survey; questionnaire; framework; prognosis; risk; impairment; severity
# 1. Introduction

Dysphagia (i.e., swallowing problems) is a symptom or a collection of symptoms of underlying anatomical abnormalities, or impairments and disorders in cognitive, sensory and motor acts involved in the transport of, mainly, food and drink from the oral cavity towards the stomach. Dysphagia may lead to reduced efficiency and safety of swallowing, failure to maintain hydration and nutrition, risk of choking and aspiration, leading to pulmonary complications and reduced quality of life [1]. In contrast to esophageal dysphagia, which typically results from a motility disorder or obstruction in the esophagus, oropharyngeal dysphagia refers to abnormalities affecting the upper esophageal sphincter, pharynx, larynx, and/or tongue.

The prevalence of oropharyngeal dysphagia in the general population has been estimated to range between 2.3 and 16% [2], but in selected patient populations pooled prevalence has been reported to be as high as 42% in stroke [3], 50.9% in cerebral palsy [4] and 72.4% in dementia [5]. Prevalence numbers may depend on the severity of underlying diseases, screening or assessment tools used to identify dysphagia, and healthcare settings [6]. To date, no international consensus exists on which outcome measures to use in order to identify and monitor oropharyngeal dysphagia [7,8]. Moreover, there is no agreement on how clinical decisions are made regarding the management and care of patients with oropharyngeal dysphagia.

Few publications are available on the subject of decision making for dysphagia relevant for selected patient populations, for instance head and neck oncology [9] and stroke [10]. However, these studies are based on limited literature and restricted numbers of clinical cases without presenting a complete overview or framework based on international consensus between healthcare professionals involved in the disease trajectory of oropharyngeal dysphagia. Alternatively, a more generic approach can be taken by applying the four-topic framework developed by Jonsen et al. [11] to support ethical reasoning in clinics. The framework is used through the identification of four domains and principles: medical indications referring to diagnostic and therapeutic interventions (i.e., the principle of beneficence and nonmaleficence); patient preferences in treatment (i.e., the principle of respect for autonomy); patient quality of life prior to and following treatment (i.e., the principle of beneficence and nonmaleficence and respect for autonomy); and, contextual features, for example, social, institutional, financial and legal settings influencing medical decisions (i.e., the principle of justice and fairness). Although this approach frames ethical dilemmas and can be applied in clinics, the framework only organises dilemmas, and clinicians are still required to use their own judgment in examining the respective weights of ethical principles [12].

The process of clinical decision making for oropharyngeal dysphagia in adults involves the identification of three factors across the disease trajectory: (1) physiological impairments of swallowing (or swallowing disability) resulting in inefficient and/or unsafe swallowing; (2) risk factors for the development of complications from oropharyngeal dysphagia; and, (3) prognostic factors for treatment outcome. Swallowing efficiency refers to the ability to transfer a bolus, secretions and/or any other material from the oral cavity, nasal cavity and paranasal sinuses, tracheobronchial tree or esophagus to the stomach without post-swallow residue, whereas swallowing safety is the ability to transfer material to the stomach without penetration and/or aspiration into the lower airways [13]. Risk factors for the development of complications from oropharyngeal dysphagia (e.g., pulmonary complications or aspiration pneumonia, reduced nutrition or oral intake, and/or poor health-related quality of life or depression) refer to patient characteristics related to health status or comorbidities, and/or health consequences due to the physiological impairment of swallowing. For example, health consequences due to tracheal residue (physiological impairment) may lead to the development of aspiration pneumonia (complication) in the presence of pulmonary disease, e.g., COPD (risk factor). Prognostic factors may impact the success of any treatment for oropharyngeal dysphagia and/or treatment of underlying etiology.
# 1. Introduction

Dysphagia (i.e., swallowing problems) is a symptom or a collection of symptoms of underlying anatomical abnormalities, or impairments and disorders in cognitive, sensory and motor acts involved in the transport of, mainly, food and drink from the oral cavity towards the stomach. Dysphagia may lead to reduced efficiency and safety of swallowing, failure to maintain hydration and nutrition, risk of choking and aspiration, leading to pulmonary complications and reduced quality of life [1]. In contrast to esophageal dysphagia, which typically results from a motility disorder or obstruction in the esophagus, oropharyngeal dysphagia refers to abnormalities affecting the upper esophageal sphincter, pharynx, larynx, and/or tongue.

The prevalence of oropharyngeal dysphagia in the general population has been estimated to range between 2.3 and 16% [2], but in selected patient populations pooled prevalence has been reported to be as high as 42% in stroke [3], 50.9% in cerebral palsy [4] and 72.4% in dementia [5]. Prevalence numbers may depend on the severity of underlying diseases, screening or assessment tools used to identify dysphagia, and healthcare settings [6]. To date, no international consensus exists on which outcome measures to use in order to identify and monitor oropharyngeal dysphagia [7,8]. Moreover, there is no agreement on how clinical decisions are made regarding the management and care of patients with oropharyngeal dysphagia.

Few publications are available on the subject of decision making for dysphagia relevant for selected patient populations, for instance head and neck oncology [9] and stroke [10]. However, these studies are based on limited literature and restricted numbers of clinical cases without presenting a complete overview or framework based on international consensus between healthcare professionals involved in the disease trajectory of oropharyngeal dysphagia. Alternatively, a more generic approach can be taken by applying the four-topic framework developed by Jonsen et al. [11] to support ethical reasoning in clinics. The framework is used through the identification of four domains and principles: medical indications referring to diagnostic and therapeutic interventions (i.e., the principle of beneficence and nonmaleficence); patient preferences in treatment (i.e., the principle of respect for autonomy); patient quality of life prior to and following treatment (i.e., the principle of beneficence and nonmaleficence and respect for autonomy); and, contextual features, for example, social, institutional, financial and legal settings influencing medical decisions (i.e., the principle of justice and fairness). Although this approach frames ethical dilemmas and can be applied in clinics, the framework only organises dilemmas, and clinicians are still required to use their own judgment in examining the respective weights of ethical principles [12].

The process of clinical decision making for oropharyngeal dysphagia in adults involves the identification of three factors across the disease trajectory: (1) physiological impairments of swallowing (or swallowing disability) resulting in inefficient and/or unsafe swallowing; (2) risk factors for the development of complications from oropharyngeal dysphagia; and, (3) prognostic factors for treatment outcome. Swallowing efficiency refers to the ability to transfer a bolus, secretions and/or any other material from the oral cavity, nasal cavity and paranasal sinuses, tracheobronchial tree or esophagus to the stomach without post-swallow residue, whereas swallowing safety is the ability to transfer material to the stomach without penetration and/or aspiration into the lower airways [13]. Risk factors for the development of complications from oropharyngeal dysphagia (e.g., pulmonary complications or aspiration pneumonia, reduced nutrition or oral intake, and/or poor health-related quality of life or depression) refer to patient characteristics related to health status or comorbidities, and/or health consequences due to the physiological impairment of swallowing. For example, health consequences due to tracheal residue (physiological impairment) may lead to the development of aspiration pneumonia (complication) in the presence of pulmonary disease, e.g., COPD (risk factor). Prognostic factors may impact the success of any treatment for oropharyngeal dysphagia and/or treatment of underlying etiology.
The aim of this study is to develop an international consensus on a clinical decision-making tree for the disease trajectory of oropharyngeal dysphagia in adults. To achieve this, the Delphi technique will be utilised, with consideration given to the physiological impairments of swallowing, risk factors for the development of complications from oropharyngeal dysphagia, and prognostic factors for treatment outcome.

## 2. Methods

### 2.1. Study Design

This study used the Delphi technique to develop international consensus on a framework for clinical decision making for the disease trajectory of oropharyngeal dysphagia in adults, taking into account: (1) *physiological impairments* of swallowing resulting in efficient and/or unsafe swallowing; (2) *risk factors* for the development of complications from oropharyngeal dysphagia (referring to patient characteristics in relation to health status or comorbidities, and/or health consequences due to physiological impairment of swallowing); and, (3) *prognostic factors* for treatment outcome and/or treatment of underlying etiology.

Group consensus between experts was achieved using a series of Delphi rounds as part of a structured process [14] during which consecutive online surveys (e-Delphi) were modified based on participants' percentage of agreement and feedback from preceding survey rounds. Delphi rounds continued until group consensus was achieved or it became obvious that consensus would not be reached. To avoid bias, participants remained anonymous throughout all Delphi rounds. For all rounds, the same experts were invited although some participants may have chosen to withdraw during the Delphi process.

### 2.2. Participants

Participants were eligible to participate in the Delphi study if they: (1) were fluent in English (i.e., able to use English adequately for work and study purposes); and, (2) had spent five years full-time equivalent (or ten years part-time equivalent) engaged in activities related to adults with dysphagia.

### 2.3. Procedure

#### 2.3.1. Recruitment

This study was approved by the Ethics Committee of Sud-Ouest et Outre Mer II (Comité de Protection des Personnes Sud-Ouest et Outre Mer II, France: 23.00117.000173). Delphi participants were recruited from the professional networks of the authors, professional organisations (e.g., the European Society for Swallowing Disorders [ESSD], the Union of European Phoniatricians [UEP] and the French Society for Deglutition and Dysphagia [SF2D]), and by asking recruited participants to identify other potential participants (snowballing). Identified potential participants were sent an invitation and information sheet about the background and purpose of the Delphi study. Participants who accepted the invitation received a link to the first online Delphi survey. All participants were reinvited for consecutive Delphi rounds regardless of whether they completed previous rounds, as survey data were processed anonymously.

#### 2.3.2. e-Delphi Surveys

A list of potential physiological impairments, risk factors and prognostic factors was constructed based on: (a) relevant international literature, and (b) group discussions between the authors. If required, definitions of the main concepts and references were listed. Potential factors were presented to participants across three Delphi rounds via an online survey platform (Limesurvey, University of Toulouse III–Paul Sabatier) over ten months (July 2022–April 2023).

Participants indicated consensus on the importance of a factor as a physiological impairment contributing to inefficient and/or unsafe swallowing, as a risk factor for the development of complications from oropharyngeal dysphagia, and/or as a prognostic factor for treatment outcome of oropharyngeal dysphagia and/or underlying etiology.
The aim of this study is to develop an international consensus on a clinical decision-making tree for the disease trajectory of oropharyngeal dysphagia in adults. To achieve this, the Delphi technique will be utilised, with consideration given to the physiological impairments of swallowing, risk factors for the development of complications from oropharyngeal dysphagia, and prognostic factors for treatment outcome.

## 2. Methods

### 2.1. Study Design

This study used the Delphi technique to develop international consensus on a framework for clinical decision making for the disease trajectory of oropharyngeal dysphagia in adults, taking into account: (1) *physiological impairments* of swallowing resulting in efficient and/or unsafe swallowing; (2) *risk factors* for the development of complications from oropharyngeal dysphagia (referring to patient characteristics in relation to health status or comorbidities, and/or health consequences due to physiological impairment of swallowing); and, (3) *prognostic factors* for treatment outcome and/or treatment of underlying etiology.

Group consensus between experts was achieved using a series of Delphi rounds as part of a structured process [14] during which consecutive online surveys (e-Delphi) were modified based on participants' percentage of agreement and feedback from preceding survey rounds. Delphi rounds continued until group consensus was achieved or it became obvious that consensus would not be reached. To avoid bias, participants remained anonymous throughout all Delphi rounds. For all rounds, the same experts were invited although some participants may have chosen to withdraw during the Delphi process.

### 2.2. Participants

Participants were eligible to participate in the Delphi study if they: (1) were fluent in English (i.e., able to use English adequately for work and study purposes); and, (2) had spent five years full-time equivalent (or ten years part-time equivalent) engaged in activities related to adults with dysphagia.

### 2.3. Procedure

#### 2.3.1. Recruitment

This study was approved by the Ethics Committee of Sud-Ouest et Outre Mer II (Comité de Protection des Personnes Sud-Ouest et Outre Mer II, France: 23.00117.000173). Delphi participants were recruited from the professional networks of the authors, professional organisations (e.g., the European Society for Swallowing Disorders [ESSD], the Union of European Phoniatricians [UEP] and the French Society for Deglutition and Dysphagia [SF2D]), and by asking recruited participants to identify other potential participants (snowballing). Identified potential participants were sent an invitation and information sheet about the background and purpose of the Delphi study. Participants who accepted the invitation received a link to the first online Delphi survey. All participants were reinvited for consecutive Delphi rounds regardless of whether they completed previous rounds, as survey data were processed anonymously.

#### 2.3.2. e-Delphi Surveys

A list of potential physiological impairments, risk factors and prognostic factors was constructed based on: (a) relevant international literature, and (b) group discussions between the authors. If required, definitions of the main concepts and references were listed. Potential factors were presented to participants across three Delphi rounds via an online survey platform (Limesurvey, University of Toulouse III–Paul Sabatier) over ten months (July 2022–April 2023).

Participants indicated consensus on the importance of a factor as a physiological impairment contributing to inefficient and/or unsafe swallowing, as a risk factor for the development of complications from oropharyngeal dysphagia, and/or as a prognostic factor for treatment outcome of oropharyngeal dysphagia and/or underlying etiology.
Participants were also asked about the relevance of agreed factors as physiological impairments, risk factors and prognostic factors in clinical decision making, within the disease trajectory of oropharyngeal dysphagia. Participants responded to all questions on importance and relevance using a five-point scale. Participants who disagreed were asked to provide further details and comments in open text boxes. In addition, respondents were asked about the comprehensiveness of the lists of potential factors and to identify missing factors to fully capture all related constructs and aspects of the process of clinical decision making in oropharyngeal dysphagia. Finally, participants were requested to select factors that most contribute to the severity of oropharyngeal dysphagia from all included factors (i.e., physiological impairments, risk factors, and prognostic factors) as agreed on during the previous two Delphi rounds. Open-ended comment sections were available at the end of each Delphi survey. Between Delphi rounds, participants received summarised findings on participants’ demographics and percentage agreement on the importance of potential factors as physiological impairments, risk factors and prognostic factors. Supplementary File S1 provides samples of all three Delphi rounds with additional details on structure and content.

## 2.4. Analysis

Survey responses were analysed using the Statistical Package for the Social Sciences [15]. Before the first Delphi round, agreed consensus between participants was defined as at least 75% of respondents indicating ‘Strongly agree’ or ‘Agree’ on importance ratings (5-point scale: strongly disagree, disagree, neither agree nor disagree, agree, strongly agree), or ‘Extremely relevant’ or ‘Very relevant’ on relevance ratings (5-point scale: extremely relevant, very relevant, moderately relevant, slightly relevant, not at all relevant) [16,17]. Responses to open-ended questions on comprehensiveness were grouped into themes where potential new factors were identified based on the aggregated feedback. The final number of Delphi rounds was to be determined by the level of consensus following each round. The authors were blinded to participants’ identities when performing data analysis.

Exploratory Principal Component factor analyses were performed on relevance ratings of factors as physiological impairments, risk factors and prognostic factors in clinical decision making in the disease trajectory of oropharyngeal dysphagia. Furthermore, Mann-Whitney *U* tests were conducted to identify differences between professions (i.e., allied health professionals and medical specialists) in rating the relevance of factors in the clinical decision-making process. Differences between professions when ranking the ten factors most contributing to the severity of oropharyngeal dysphagia were compared using descriptive statistics.

# 3. Results

## 3.1. Delphi Participants

Potential candidates were identified through authors’ networks, professional organisations and snowballing. The numbers of participants who completed the three consecutive Delphi rounds were 75, 62 and 69, respectively. Table 1 presents the participants’ demographics. Across Delphi rounds, participants’ backgrounds varied slightly. Allied health professionals (49.3–60.1%) were mainly represented by speech–language pathologists (42.7–45.2%) in addition to occupational therapists and physiotherapists. About half of the medical specialists (39.9–50.7%) were otolaryngologists/phoniatricians (24.2–27.5%), whereas the remaining medical doctors represented a variety of specialties (e.g., radiologists, geriatricians, gastroenterologists and physiatrists). Most participants had completed a higher degree by research (62.3–62.9%) or Master’s degrees (29.0–36.7%), and showed wide variety in years of working with adults with dysphagia: 5–10 years (11.6–21.0%), 11–20 year (38.7–46.3%), and over 20 years of experience (41.9–44.0%). The majority of respondents were clinicians or clinical supervisors (71.0–76.0%) in addition to researchers (8.1–10.7%) and academics (12.0–14.5%), whose primary practice settings were mostly
Participants were also asked about the relevance of agreed factors as physiological impairments, risk factors and prognostic factors in clinical decision making, within the disease trajectory of oropharyngeal dysphagia. Participants responded to all questions on importance and relevance using a five-point scale. Participants who disagreed were asked to provide further details and comments in open text boxes. In addition, respondents were asked about the comprehensiveness of the lists of potential factors and to identify missing factors to fully capture all related constructs and aspects of the process of clinical decision making in oropharyngeal dysphagia. Finally, participants were requested to select factors that most contribute to the severity of oropharyngeal dysphagia from all included factors (i.e., physiological impairments, risk factors, and prognostic factors) as agreed on during the previous two Delphi rounds. Open-ended comment sections were available at the end of each Delphi survey. Between Delphi rounds, participants received summarised findings on participants’ demographics and percentage agreement on the importance of potential factors as physiological impairments, risk factors and prognostic factors. Supplementary File S1 provides samples of all three Delphi rounds with additional details on structure and content.

## 2.4. Analysis

Survey responses were analysed using the Statistical Package for the Social Sciences [15]. Before the first Delphi round, agreed consensus between participants was defined as at least 75% of respondents indicating ‘Strongly agree’ or ‘Agree’ on importance ratings (5-point scale: strongly disagree, disagree, neither agree nor disagree, agree, strongly agree), or ‘Extremely relevant’ or ‘Very relevant’ on relevance ratings (5-point scale: extremely relevant, very relevant, moderately relevant, slightly relevant, not at all relevant) [16,17]. Responses to open-ended questions on comprehensiveness were grouped into themes where potential new factors were identified based on the aggregated feedback. The final number of Delphi rounds was to be determined by the level of consensus following each round. The authors were blinded to participants’ identities when performing data analysis.

Exploratory Principal Component factor analyses were performed on relevance ratings of factors as physiological impairments, risk factors and prognostic factors in clinical decision making in the disease trajectory of oropharyngeal dysphagia. Furthermore, Mann-Whitney U tests were conducted to identify differences between professions (i.e., allied health professionals and medical specialists) in rating the relevance of factors in the clinical decision-making process. Differences between professions when ranking the ten factors most contributing to the severity of oropharyngeal dysphagia were compared using descriptive statistics.

# 3. Results

## 3.1. Delphi Participants

Potential candidates were identified through authors’ networks, professional organisations and snowballing. The numbers of participants who completed the three consecutive Delphi rounds were 75, 62 and 69, respectively. Table 1 presents the participants’ demographics. Across Delphi rounds, participants’ backgrounds varied slightly. Allied health professionals (49.3–60.1%) were mainly represented by speech–language pathologists (42.7–45.2%) in addition to occupational therapists and physiotherapists. About half of the medical specialists (39.9–50.7%) were otolaryngologists/phoniatricians (24.2–27.5%), whereas the remaining medical doctors represented a variety of specialties (e.g., radiologists, geriatricians, gastroenterologists and physiatrists). Most participants had completed a higher degree by research (62.3–62.9%) or Master’s degrees (29.0–36.7%), and showed wide variety in years of working with adults with dysphagia: 5–10 years (11.6–21.0%), 11–20 year (38.7–46.3%), and over 20 years of experience (41.9–44.0%). The majority of respondents were clinicians or clinical supervisors (71.0–76.0%) in addition to researchers (8.1–10.7%) and academics (12.0–14.5%), whose primary practice settings were mostly
hospitals (66.7–75.8%), university/education (8.1–17.4%) and private practice (4.8–12.0%). Most frequently, participants worked with patients with non-degenerative neurological diseases (33.3–43.5%), oncology patients (23.2–24.2%) and geriatric populations (6.5–14.7%). Participants, of which over 80% originated from Europe, were spread across 31 countries and five continents. Further details can be found in Table 1.

<table><caption>**Table 1.** Participant demographics.</caption><thead><tr><th>Round</th><th>Round One</th><th>Round Two</th><th>Round Three</th></tr></thead><tbody><tr><td>Number of Participants</td><td>N = 75</td><td>N = 62</td><td>N = 69</td></tr><tr><td>Demographics</td><td>Frequency (%)</td><td>Frequency (%)</td><td>Frequency (%)</td></tr><tr><td>Continent of Residence</td><td></td><td></td><td></td></tr><tr><td>Asia (Participants; Countries)</td><td>4 (5.3%; 4)<br>(Hong Kong [n = 1], Lebanon<br>[n = 1], Philippines [n = 1],<br>United Arab Emirates [n = 1])</td><td>4 (6.5%; 4)<br>(Hong Kong [n = 1], Japan<br>[n = 1], Lebanon [n = 1], United<br>Arab Emirates [n = 1])</td><td>6 (8.7%; 4)<br>(Hong Kong [n = 1], Japan [n = 1],<br>Turkey [n = 3], United Arab<br>Emirates [n = 1])</td></tr><tr><td>Europe (Participants; Countries)</td><td>60 (80.0%; 20<sup>a</sup>)</td><td>50 (80.6%; 17<sup>b</sup>)</td><td>56 (81.2%; 19<sup>c</sup>)</td></tr><tr><td>North America (Participants; Countries)</td><td>3 (4.0%; 2)<br>(Canada [n = 2], United States<br>[n = 1])</td><td>2 (3.2%; 2)<br>(Canada [n = 1], United States<br>[n = 1])</td><td>2 (2.9%; 1)<br>(Canada [n = 2])</td></tr><tr><td>Oceania (Participants; Countries)</td><td>3 (4.0%; 2)<br>(Australia [n = 2], New<br>Zealand [n = 1])</td><td>3 (4.8%; 2)<br>(Australia [n = 2], New Zealand<br>[n = 2])</td><td>1 (1.4%; 1)<br>(Australia [n = 1])</td></tr><tr><td>South America (Participants; Countries)</td><td>5 (6.7%; 1)<br>(Brazil [n = 5])</td><td>3 (4.8%; 1)<br>(Brazil [n = 3])</td><td>4 (5.8%; 1)<br>(Brazil [n = 4])</td></tr><tr><td>Highest qualification (related to work in the field of dysphagia)</td><td></td><td></td><td></td></tr><tr><td>Bachelor</td><td>N.A.</td><td>5 (8.1%)</td><td>4 (5.8%)</td></tr><tr><td>Master</td><td>27 (36.0%)</td><td>18 (29.0%)</td><td>22 (36.7%)</td></tr><tr><td>PhD</td><td>47 (62.7%)</td><td>39 (62.9%)</td><td>43 (62.3%)</td></tr><tr><td>Profession</td><td></td><td></td><td></td></tr><tr><td>Speech Language Pathologist</td><td>32 (42.7%)</td><td>28 (45.2%)</td><td>31 (44.9%)</td></tr><tr><td>Occupational Therapist</td><td>3 (4.0%)</td><td>4 (6.4%)</td><td>4 (5.8%)</td></tr><tr><td>Physiotherapist</td><td>2 (2.7%)</td><td>4 (6.4%)</td><td>3 (4.3%)</td></tr><tr><td>ENT/Phoniatrician</td><td>18 (24.0%)</td><td>15 (24.2%)</td><td>19 (27.5%)</td></tr><tr><td>Radiologist</td><td>6 (8.0%)</td><td>3 (4.8%)</td><td>4 (5.8%)</td></tr><tr><td>Other Medical Specialist</td><td>8 (10.7%)</td><td>5 (8.1%)</td><td>6 (8.7%)</td></tr><tr><td>Dual Allied Health Med Spec</td><td>6 (8.0%)</td><td>3 (4.8%)</td><td>N.A.</td></tr><tr><td>Primary role</td><td></td><td></td><td></td></tr><tr><td>Clinician/Clinical supervisor</td><td>57 (76.0%)</td><td>46 (74.2%)</td><td>49 (71.0%)</td></tr><tr><td>Researcher</td><td>8 (10.7%)</td><td>5 (8.1%)</td><td>6 (8.7%)</td></tr><tr><td>Academic</td><td>9 (12.0%)</td><td>9 (14.5%)</td><td>9 (13.0%)</td></tr><tr><td>Teacher</td><td>N.A.</td><td>1 (1.6%)</td><td>1 (1.4%)</td></tr><tr><td>Not currently working</td><td>1 (1.3%)</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Practice setting (Primary)</td><td></td><td></td><td></td></tr><tr><td>Hospital</td><td>50 (66.7%)</td><td>47 (75.8%)</td><td>50 (72.5%)</td></tr><tr><td>Community</td><td>2 (2.7%)</td><td>3 (4.8%)</td><td>N.A.</td></tr><tr><td>Private Practice</td><td>9 (12.0%)</td><td>3 (4.8%)</td><td>5 (7.2%)</td></tr><tr><td>Residential Aged Care</td><td>1 (1.3%)</td><td>1 (1.6%)</td><td>2 (2.9%)</td></tr><tr><td>University/Education</td><td>12 (16.0%)</td><td>5 (8.1%)</td><td>12 (17.4%)</td></tr><tr><td>Student</td><td>1 (1.3%)</td><td>1 (1.6%)</td><td>N.A.</td></tr><tr><td>Other</td><td>N.A.</td><td>2 (3.2%)<sup>d</sup></td><td>N.A.</td></tr><tr><td>Practice setting (secondary)</td><td></td><td></td><td></td></tr><tr><td>No Secondary Sector</td><td>23 (30.7%)</td><td>13 (21.0%)</td><td>23 (33.3%)</td></tr><tr><td>Hospital</td><td>8 (10.7%)</td><td>3 (6.5%)</td><td>7 (10.1%)</td></tr><tr><td>Community</td><td>4 (5.3%)</td><td>3 (6.5%)</td><td>6 (8.7%)</td></tr></tbody></table>
hospitals (66.7–75.8%), university/education (8.1–17.4%) and private practice (4.8–12.0%). Most frequently, participants worked with patients with non-degenerative neurological diseases (33.3–43.5%), oncology patients (23.2–24.2%) and geriatric populations (6.5–14.7%). Participants, of which over 80% originated from Europe, were spread across 31 countries and five continents. Further details can be found in Table 1.

<table><caption>**Table 1.** Participant demographics.</caption><thead><tr><th>Round</th><th>Round One</th><th>Round Two</th><th>Round Three</th></tr></thead><tbody><tr><td>Number of Participants</td><td>N = 75</td><td>N = 62</td><td>N = 69</td></tr><tr><td>Demographics</td><td>Frequency (%)</td><td>Frequency (%)</td><td>Frequency (%)</td></tr><tr><td>Continent of Residence</td><td></td><td></td><td></td></tr><tr><td>Asia (Participants; Countries)</td><td>4 (5.3%; 4)<br>(Hong Kong [n = 1], Lebanon<br>[n = 1], Philippines [n = 1],<br>United Arab Emirates [n = 1])</td><td>4 (6.5%; 4)<br>(Hong Kong [n = 1], Japan<br>[n = 1], Lebanon [n = 1], United<br>Arab Emirates [n = 1])</td><td>6 (8.7%; 4)<br>(Hong Kong [n = 1], Japan [n = 1],<br>Turkey [n = 3], United Arab<br>Emirates [n = 1])</td></tr><tr><td>Europe (Participants; Countries)</td><td>60 (80.0%; 20 <sup>a</sup>)</td><td>50 (80.6%; 17 <sup>b</sup>)</td><td>56 (81.2%; 19 <sup>c</sup>)</td></tr><tr><td>North America (Participants; Countries)</td><td>3 (4.0%; 2)<br>(Canada [n = 2], United States<br>[n = 1])</td><td>2 (3.2%; 2)<br>(Canada [n = 1], United States<br>[n = 1])</td><td>2 (2.9%; 1)<br>(Canada [n = 2])</td></tr><tr><td>Oceania (Participants; Countries)</td><td>3 (4.0%; 2)<br>(Australia [n = 2], New<br>Zealand [n = 1])</td><td>3 (4.8%; 2)<br>(Australia [n = 2], New Zealand<br>[n = 2])</td><td>1 (1.4%; 1)<br>(Australia [n = 1])</td></tr><tr><td>South America (Participants; Countries)</td><td>5 (6.7%; 1)<br>(Brazil [n = 5])</td><td>3 (4.8%; 1)<br>(Brazil [n = 3])</td><td>4 (5.8%; 1)<br>(Brazil [n = 4])</td></tr><tr><td>Highest qualification (related to work in the field of dysphagia)</td><td></td><td></td><td></td></tr><tr><td>Bachelor</td><td>N.A.</td><td>5 (8.1%)</td><td>4 (5.8%)</td></tr><tr><td>Master</td><td>27 (36.0%)</td><td>18 (29.0%)</td><td>22 (36.7%)</td></tr><tr><td>PhD</td><td>47 (62.7%)</td><td>39 (62.9%)</td><td>43 (62.3%)</td></tr><tr><td>Profession</td><td></td><td></td><td></td></tr><tr><td>Speech Language Pathologist</td><td>32 (42.7%)</td><td>28 (45.2%)</td><td>31 (44.9%)</td></tr><tr><td>Occupational Therapist</td><td>3 (4.0%)</td><td>4 (6.4%)</td><td>4 (5.8%)</td></tr><tr><td>Physiotherapist</td><td>2 (2.7%)</td><td>4 (6.4%)</td><td>3 (4.3%)</td></tr><tr><td>ENT/Phoniatrician</td><td>18 (24.0%)</td><td>15 (24.2%)</td><td>19 (27.5%)</td></tr><tr><td>Radiologist</td><td>6 (8.0%)</td><td>3 (4.8%)</td><td>4 (5.8%)</td></tr><tr><td>Other Medical Specialist</td><td>8 (10.7%)</td><td>5 (8.1%)</td><td>6 (8.7%)</td></tr><tr><td>Dual Allied Health Med Spec</td><td>6 (8.0%)</td><td>3 (4.8%)</td><td>N.A.</td></tr><tr><td>Primary role</td><td></td><td></td><td></td></tr><tr><td>Clinician/Clinical supervisor</td><td>57 (76.0%)</td><td>46 (74.2%)</td><td>49 (71.0%)</td></tr><tr><td>Researcher</td><td>8 (10.7%)</td><td>5 (8.1%)</td><td>6 (8.7%)</td></tr><tr><td>Academic</td><td>9 (12.0%)</td><td>9 (14.5%)</td><td>9 (13.0%)</td></tr><tr><td>Teacher</td><td>N.A.</td><td>1 (1.6%)</td><td>1 (1.4%)</td></tr><tr><td>Not currently working</td><td>1 (1.3%)</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Practice setting (Primary)</td><td></td><td></td><td></td></tr><tr><td>Hospital</td><td>50 (66.7%)</td><td>47 (75.8%)</td><td>50 (72.5%)</td></tr><tr><td>Community</td><td>2 (2.7%)</td><td>3 (4.8%)</td><td>N.A.</td></tr><tr><td>Private Practice</td><td>9 (12.0%)</td><td>3 (4.8%)</td><td>5 (7.2%)</td></tr><tr><td>Residential Aged Care</td><td>1 (1.3%)</td><td>1 (1.6%)</td><td>2 (2.9%)</td></tr><tr><td>University/Education</td><td>12 (16.0%)</td><td>5 (8.1%)</td><td>12 (17.4%)</td></tr><tr><td>Student</td><td>1 (1.3%)</td><td>1 (1.6%)</td><td>N.A.</td></tr><tr><td>Other</td><td>N.A.</td><td>2 (3.2%) <sup>d</sup></td><td>N.A.</td></tr><tr><td>Practice setting (secondary)</td><td></td><td></td><td></td></tr><tr><td>No Secondary Sector</td><td>23 (30.7%)</td><td>13 (21.0%)</td><td>23 (33.3%)</td></tr><tr><td>Hospital</td><td>8 (10.7%)</td><td>3 (6.5%)</td><td>7 (10.1%)</td></tr><tr><td>Community</td><td>4 (5.3%)</td><td>3 (6.5%)</td><td>6 (8.7%)</td></tr></tbody></table>
<table><caption>Table 1. *Cont.*</caption><thead><tr><th>Round</th><th>Round One</th><th>Round Two</th><th>Round Three</th></tr></thead><tbody><tr><td>Number of Participants</td><td>N = 75</td><td>N = 62</td><td>N = 69</td></tr><tr><td>Demographics</td><td>Frequency (%)</td><td>Frequency (%)</td><td>Frequency (%)</td></tr><tr><td>Private Practice</td><td>5 (6.7%)</td><td>6 (9.7%)</td><td>6 (8.7%)</td></tr><tr><td>Residential Aged Care</td><td>3 (4.0%)</td><td>2 (3.2%)</td><td>1 (1.4%)</td></tr><tr><td>University/Education</td><td>26 (34.7%)</td><td>24 (38.7%)</td><td>20 (29%)</td></tr><tr><td>Student</td><td>6 (8.0%)</td><td>8 (12.9%)</td><td>6 (8.7%)</td></tr><tr><td>Patient populations (Primary)</td><td></td><td></td><td></td></tr><tr><td>Non-degenerative Neurology</td><td>25 (33.3%)</td><td>26 (41.9%)</td><td>30 (43.5%)</td></tr><tr><td>Degenerative Neurology</td><td>8 (10.7%)</td><td>7 (11.3%)</td><td>2 (2.9%)</td></tr><tr><td>Oncology</td><td>18 (24.0%)</td><td>15 (24.2%)</td><td>16 (23.2%)</td></tr><tr><td>Gastroenterology</td><td>5 (6.7%)</td><td>1 (1.6%)</td><td>1 (1.4%)</td></tr><tr><td>Geriatrics</td><td>11 (14.7%)</td><td>4 (6.5%)</td><td>8 (11.6%)</td></tr><tr><td>Respiratory diseases</td><td>N.A.</td><td>1 (1.6%)</td><td>2 (2.9%)</td></tr><tr><td>Combined</td><td>7 (9.3%)</td><td>4 (6.5%)</td><td>6 (8.7%)</td></tr><tr><td>Other</td><td>N.A.</td><td>3 (4.8%)</td><td>N.A.</td></tr><tr><td>Patient populations (Secondary)</td><td></td><td></td><td></td></tr><tr><td>No Secondary Population</td><td>5 (6.7%)</td><td>12 (19.4%)</td><td>5 (7.2%)</td></tr><tr><td>Non-degenerative Neurology</td><td>17 (22.7%)</td><td>11 (17.7%)</td><td>8 (11.6%)</td></tr><tr><td>Degenerative Neurology</td><td>22 (29.3%)</td><td>20 (32.3%)</td><td>22 (31.9%)</td></tr><tr><td>Oncology</td><td>8 (10.7%)</td><td>10 (16.1%)</td><td>8 (11.6%)</td></tr><tr><td>Gastroenterology</td><td>5 (6.7%)</td><td>1 (1.6%)</td><td>7 (10.1%)</td></tr><tr><td>Geriatrics</td><td>6 (8.0%)</td><td>2 (3.2%)</td><td>6 (8.7%)</td></tr><tr><td>Respiratory diseases</td><td>6 (8.0%)</td><td>5 (8.1%)</td><td>5 (7.2%)</td></tr><tr><td>Combined</td><td>4 (5.3%)</td><td>1 (1.6%)</td><td>4 (5.8%)</td></tr><tr><td>Other</td><td>1 (1.3%)</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Years of experience</td><td></td><td></td><td></td></tr><tr><td>5–10</td><td>13 (17.3%)</td><td>13 (21.0%)</td><td>8 (11.6%)</td></tr><tr><td>11–15</td><td>20 (26.7%)</td><td>14 (22.6%)</td><td>17 (24.6%)</td></tr><tr><td>16–20</td><td>9 (12.0%)</td><td>9 (14.5%)</td><td>15 (21.7%)</td></tr><tr><td>21–30</td><td>24 (32.0%)</td><td>19 (30.6%)</td><td>21 (30.4%)</td></tr><tr><td>>30</td><td>9 (12.0%)</td><td>7 (11.3%)</td><td>8 (11.6%)</td></tr></tbody></table>

Note. N.A. = Not Applicable. <sup>a</sup> Austria [n = 3], Belgium [n = 5], Croatia [n = 1], Denmark [n = 3], Estonia [n = 1], Finland [n = 2], France [n = 16], Germany [n = 3], Greece [n = 2], Italy [n = 3], Norway [n = 3], Portugal [n = 1], Slovakia [n = 2], Slovenia [n = 1], Spain [n = 1], Sweden [n = 3], Switzerland [n = 3], the Netherlands [n = 2], Ukraine [n = 1], United Kingdom [n = 4]. <sup>b</sup> Austria [n = 4], Belgium [n = 5], Croatia [n = 1], Denmark [n = 4], Finland [n = 1], France [n = 12], Germany [n = 2], Italy [n = 2], Norway [n = 2], Portugal [n = 1], Slovakia [n = 3], Slovenia [n = 2], Spain [n = 2], Sweden [n = 2], the Netherlands [n = 2], Ukraine [n = 1], United Kingdom [n = 4]. <sup>c</sup> Austria [n = 3], Belgium [n = 6], Croatia [n = 1], Denmark [n = 4], Estonia [n = 1], Finland [n = 2], France [n = 14], Germany [n = 3], Italy [n = 2], Norway [n = 2], Portugal [n = 2], Slovakia [n = 2], Slovenia [n = 2], Spain [n = 1], Sweden [n = 2], Switzerland [n = 2], the Netherlands [n = 2], Ukraine [n = 1], United Kingdom [n = 4]. <sup>d</sup> Currently not working (n = 1), Currently not working in dysphagia (n = 1).

## 3.2. Delphi Process

In addition to Supplementary File S1 providing an overview of the structure and content of all three Delphi rounds with listed example questions, a summary of the Delphi process is outlined in Table 2.
<table><caption>Table 1. *Cont.*</caption><thead><tr><th>Round</th><th>Round One</th><th>Round Two</th><th>Round Three</th></tr></thead><tbody><tr><td>Number of Participants</td><td>N = 75</td><td>N = 62</td><td>N = 69</td></tr><tr><td>Demographics</td><td>Frequency (%)</td><td>Frequency (%)</td><td>Frequency (%)</td></tr><tr><td>Private Practice</td><td>5 (6.7%)</td><td>6 (9.7%)</td><td>6 (8.7%)</td></tr><tr><td>Residential Aged Care</td><td>3 (4.0%)</td><td>2 (3.2%)</td><td>1 (1.4%)</td></tr><tr><td>University/Education</td><td>26 (34.7%)</td><td>24 (38.7%)</td><td>20 (29%)</td></tr><tr><td>Student</td><td>6 (8.0%)</td><td>8 (12.9%)</td><td>6 (8.7%)</td></tr><tr><td>Patient populations (Primary)</td><td></td><td></td><td></td></tr><tr><td>Non-degenerative Neurology</td><td>25 (33.3%)</td><td>26 (41.9%)</td><td>30 (43.5%)</td></tr><tr><td>Degenerative Neurology</td><td>8 (10.7%)</td><td>7 (11.3%)</td><td>2 (2.9%)</td></tr><tr><td>Oncology</td><td>18 (24.0%)</td><td>15 (24.2%)</td><td>16 (23.2%)</td></tr><tr><td>Gastroenterology</td><td>5 (6.7%)</td><td>1 (1.6%)</td><td>1 (1.4%)</td></tr><tr><td>Geriatrics</td><td>11 (14.7%)</td><td>4 (6.5%)</td><td>8 (11.6%)</td></tr><tr><td>Respiratory diseases</td><td>N.A.</td><td>1 (1.6%)</td><td>2 (2.9%)</td></tr><tr><td>Combined</td><td>7 (9.3%)</td><td>4 (6.5%)</td><td>6 (8.7%)</td></tr><tr><td>Other</td><td>N.A.</td><td>3 (4.8%)</td><td>N.A.</td></tr><tr><td>Patient populations (Secondary)</td><td></td><td></td><td></td></tr><tr><td>No Secondary Population</td><td>5 (6.7%)</td><td>12 (19.4%)</td><td>5 (7.2%)</td></tr><tr><td>Non-degenerative Neurology</td><td>17 (22.7%)</td><td>11 (17.7%)</td><td>8 (11.6%)</td></tr><tr><td>Degenerative Neurology</td><td>22 (29.3%)</td><td>20 (32.3%)</td><td>22 (31.9%)</td></tr><tr><td>Oncology</td><td>8 (10.7%)</td><td>10 (16.1%)</td><td>8 (11.6%)</td></tr><tr><td>Gastroenterology</td><td>5 (6.7%)</td><td>1 (1.6%)</td><td>7 (10.1%)</td></tr><tr><td>Geriatrics</td><td>6 (8.0%)</td><td>2 (3.2%)</td><td>6 (8.7%)</td></tr><tr><td>Respiratory diseases</td><td>6 (8.0%)</td><td>5 (8.1%)</td><td>5 (7.2%)</td></tr><tr><td>Combined</td><td>4 (5.3%)</td><td>1 (1.6%)</td><td>4 (5.8%)</td></tr><tr><td>Other</td><td>1 (1.3%)</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Years of experience</td><td></td><td></td><td></td></tr><tr><td>5–10</td><td>13 (17.3%)</td><td>13 (21.0%)</td><td>8 (11.6%)</td></tr><tr><td>11–15</td><td>20 (26.7%)</td><td>14 (22.6%)</td><td>17 (24.6%)</td></tr><tr><td>16–20</td><td>9 (12.0%)</td><td>9 (14.5%)</td><td>15 (21.7%)</td></tr><tr><td>21–30</td><td>24 (32.0%)</td><td>19 (30.6%)</td><td>21 (30.4%)</td></tr><tr><td>&gt;30</td><td>9 (12.0%)</td><td>7 (11.3%)</td><td>8 (11.6%)</td></tr></tbody></table>

Note. N.A. = Not Applicable. <sup>a</sup> Austria [n = 3], Belgium [n = 5], Croatia [n = 1], Denmark [n = 3], Estonia [n = 1], Finland [n = 2], France [n = 16], Germany [n = 3], Greece [n = 2], Italy [n = 3], Norway [n = 3], Portugal [n = 1], Slovakia [n = 2], Slovenia [n = 1], Spain [n = 1], Sweden [n = 3], Switzerland [n = 3], the Netherlands [n = 2], Ukraine [n = 1], United Kingdom [n = 4]. <sup>b</sup> Austria [n = 4], Belgium [n = 5], Croatia [n = 1], Denmark [n = 4], Finland [n = 1], France [n = 12], Germany [n = 2], Italy [n = 2], Norway [n = 2], Portugal [n = 1], Slovakia [n = 3], Slovenia [n = 2], Spain [n = 2], Sweden [n = 2], the Netherlands [n = 2], Ukraine [n = 1], United Kingdom [n = 4]. <sup>c</sup> Austria [n = 3], Belgium [n = 6], Croatia [n = 1], Denmark [n = 4], Estonia [n = 1], Finland [n = 2], France [n = 14], Germany [n = 3], Italy [n = 2], Norway [n = 2], Portugal [n = 2], Slovakia [n = 2], Slovenia [n = 2], Spain [n = 1], Sweden [n = 2], Switzerland [n = 2], the Netherlands [n = 2], Ukraine [n = 1], United Kingdom [n = 4]. <sup>d</sup> Currently not working (n = 1), Currently not working in dysphagia (n = 1).

## 3.2. Delphi Process

In addition to Supplementary File S1 providing an overview of the structure and content of all three Delphi rounds with listed example questions, a summary of the Delphi process is outlined in Table 2.
<table><caption>Table 2. Overview of Delphi process.</caption><thead><tr><th>Round (N<sub>participants</sub>)</th><th>Content</th><th>Results</th></tr></thead><tbody><tr><td></td><td><strong>IMPORTANCE AND COMPREHENSIVENESS</strong></td><td></td></tr><tr><td></td><td><strong>PART I List of potential factors: Physiological Impairments, Risk Factor and/or Prognostic Factor (n = 22)</strong><br>Questions <sup>a</sup> (5-point ordinal scale)</td><td></td></tr><tr><td></td><td><ul><li>This factor is an important physiological impairment contributing to inefficient and/or unsafe swallowing.</li><li>This factor is an important risk factor for the development of complications from oropharyngeal dysphagia.</li><li>This factor is an important prognostic factor for treatment outcome or oropharyngeal dysphagia and/or underlying aetiology.</li></ul></td><td><strong>FACTORS Included: Agreement <sup>b</sup></strong><br><ul><li>Physiological Impairments (n = 12)</li><li>Risk Factor (n = 28)</li><li>Prognostic Factor (n = 26)</li></ul></td></tr><tr><td>Round I (N = 75)</td><td><strong>PART II List of potential factors: Risk Factor and/or Prognostic Factor (n = 22)</strong><br>Questions <sup>a,b</sup> (5-point ordinal scale)</td><td><strong>FACTORS Excluded: No agreement <sup>b</sup></strong><br><ul><li>Physiological Impairments (n = 10)</li><li>Risk Factor (n = 16)</li><li>Prognostic Factor (n = 18)</li></ul></td></tr><tr><td></td><td><strong>PART III Comprehensiveness</strong><br>Overview of all potential Physiological Impairments, Risk Factors and/or Prognostic Factors (Open) Question</td><td><strong>NEW potential FACTORS (Include Round II)</strong><br><ul><li>Physiological Impairments (n = 18)</li><li>Risk Factor (n = 23)</li><li>Prognostic Factor (n = 23)</li></ul></td></tr><tr><td></td><td><ul><li>Focus on comprehensiveness; are any important factors missing?</li></ul></td><td></td></tr><tr><td></td><td><strong>IMPORTANCE AND COMPREHENSIVENESS</strong></td><td></td></tr><tr><td></td><td><strong>PART I List of new potential factors: Physiological Impairments, Risk Factors and/or Prognostic factors from Round I, Part III (n = 18)</strong><br>Questions as per Round I (Part I)</td><td><strong>NEW FACTORS Included: Agreement <sup>b</sup></strong><br><ul><li>Physiological Impairments (n = 9)</li><li>Risk Factor (n = 15)</li><li>Prognostic factor (n = 13)</li></ul></td></tr><tr><td>Round II (N = 62)</td><td><strong>PART II List of new Risk Factors and/or Prognostic factors from Round I, Part III (n = 23)</strong><br>Questions as per Round I (Part II)</td><td><strong>NEW FACTORS Excluded: No agreement <sup>b</sup></strong><br><ul><li>Physiological Impairments (n = 9)</li><li>Risk Factor (n = 8)</li><li>Prognostic factor (n = 10)</li></ul></td></tr><tr><td></td><td><strong>PART III Comprehensiveness</strong><br>Overview of all potential Physiological Impairments, Risk Factors and/or Prognostic factors (Open) Question as per Round I (Part III)</td><td><strong>NEW potential FACTORS (Include Round III)</strong><br><ul><li>No new factors (n = 0)</li></ul></td></tr><tr><td></td><td><strong>RELEVANCE AND RANK ORDER</strong></td><td></td></tr><tr><td></td><td><strong>PART I List of included Physiological Impairments (n = 21)</strong><br>Questions <sup>a,b</sup> (5-point ordinal scale)</td><td></td></tr><tr><td></td><td><ul><li>Rate the relevance of the physiological impairment in clinical decision making in the disease trajectory of oropharyngeal dysphagia.</li></ul></td><td><strong>FACTORS Included: Agreement <sup>b</sup></strong><br><ul><li>Physiological Impairments (n = 10)</li><li>Risk Factor (n = 23)</li><li>Prognostic Factor (n = 20)</li></ul></td></tr><tr><td>Round III (N = 69)</td><td><strong>PART II List of included Risk Factors (n = 43)</strong><br>Questions <sup>a,b</sup> (5-point ordinal scale)</td><td><strong>FACTORS Excluded: No agreement <sup>b</sup></strong><br><ul><li>Physiological Impairments (n = 11)</li><li>Risk Factor (n = 21)</li><li>Prognostic Factor (n = 18)</li></ul></td></tr><tr><td></td><td><ul><li>Rate the relevance of the risk factor in clinical decision making in the disease trajectory of oropharyngeal dysphagia.</li></ul></td><td></td></tr><tr><td></td><td><strong>PART III List of included Prognostic Factors (n = 39)</strong><br>Questions <sup>a,b</sup> (5-point ordinal scale)</td><td></td></tr><tr><td></td><td><ul><li>Rate the relevance of the prognostic factor in clinical decision making in the disease trajectory of oropharyngeal dysphagia.</li></ul></td><td></td></tr><tr><td></td><td><strong>PART IV List of all included factors (i.e., physiological impairments, risk factors, and prognostic factors) as agreed on during Round I and II (n = 50)</strong><br>Question</td><td></td></tr><tr><td></td><td><ul><li>Select and rank up to ten factors that most contribute to the severity of oropharyngeal dysphagia.</li></ul></td><td></td></tr></tbody></table>

### 3.2.1. Delphi Round I

The first Delphi round included: (1) a list of 22 items of potential physiological impairments, risk factors and prognostic factors (Part I), and (2) an additional 22 items of potential risk factors and prognostic factors only (Part II). Participants were asked to rate

<footnote><sup>a</sup> If 'Disagree' or 'Strongly disagree', changes can be suggested in comment boxes. <sup>b</sup> Consensus agreement is defined as ≥75% of participants rating 'Strongly agree' or 'Agree'.</footnote>
<table><caption>Table 2. Overview of Delphi process.</caption><thead><tr><th>Round (N<sub>participants</sub>)</th><th>Content</th><th>Results</th></tr></thead><tbody><tr><td></td><td><strong>IMPORTANCE AND COMPREHENSIVENESS</strong><br><strong>PART I List of potential factors: Physiological Impairments, Risk Factor and/or Prognostic Factor (n = 22)</strong><br>Questions <sup>a</sup> (5-point ordinal scale)<ul><li>This factor is an important physiological impairment contributing to inefficient and/or unsafe swallowing.</li><li>This factor is an important risk factor for the development of complications from oropharyngeal dysphagia.</li><li>This factor is an important prognostic factor for treatment outcome or oropharyngeal dysphagia and/or underlying aetiology.</li></ul><strong>PART II List of potential factors: Risk Factor and/or Prognostic Factor (n = 22)</strong><br>Questions <sup>a,b</sup> (5-point ordinal scale)<ul><li>This factor is an important risk factor for the development of complications from oropharyngeal dysphagia.</li><li>This factor is an important prognostic factor for treatment outcome or oropharyngeal dysphagia and/or underlying aetiology.</li></ul><strong>PART III Comprehensiveness</strong><br>Overview of all potential Physiological Impairments, Risk Factors and/or Prognostic Factors (Open) Question<ul><li>Focus on comprehensiveness; are any important factors missing?</li></ul></td><td><strong>FACTORS Included: Agreement <sup>b</sup></strong><ul><li>Physiological Impairments (n = 12)</li><li>Risk Factor (n = 28)</li><li>Prognostic Factor (n = 26)</li></ul><strong>FACTORS Excluded: No agreement <sup>b</sup></strong><ul><li>Physiological Impairments (n = 10)</li><li>Risk Factor (n = 16)</li><li>Prognostic Factor (n = 18)</li></ul><strong>NEW potential FACTORS (Include Round II)</strong><ul><li>Physiological Impairments (n = 18)</li><li>Risk Factor (n = 23)</li><li>Prognostic Factor (n = 23)</li></ul></td></tr><tr><td>Round I (N = 75)</td><td><strong>IMPORTANCE AND COMPREHENSIVENESS</strong><br><strong>PART I List of new potential factors: Physiological Impairments, Risk Factors and/or Prognostic factors from Round I, Part III (n = 18)</strong><br>Questions as per Round I (Part I)<br><strong>PART II List of new Risk Factors and/or Prognostic factors from Round I, Part III (n = 23)</strong><br>Questions as per Round I (Part II)<br><strong>PART III Comprehensiveness</strong><br>Overview of all potential Physiological Impairments, Risk Factors and/or Prognostic factors (Open) Question as per Round I (Part III)</td><td><strong>NEW FACTORS Included: Agreement <sup>b</sup></strong><ul><li>Physiological Impairments (n = 9)</li><li>Risk Factor (n = 15)</li><li>Prognostic factor (n = 13)</li></ul><strong>NEW FACTORS Excluded: No agreement <sup>b</sup></strong><ul><li>Physiological Impairments (n = 9)</li><li>Risk Factor (n = 8)</li><li>Prognostic factor (n = 10)</li></ul><strong>NEW potential FACTORS (Include Round III)</strong><ul><li>No new factors (n = 0)</li></ul></td></tr><tr><td>Round II (N = 62)</td><td><strong>RELEVANCE AND RANK ORDER</strong><br><strong>PART I List of included Physiological Impairments (n = 21)</strong><br>Questions <sup>a,b</sup> (5-point ordinal scale)<ul><li>Rate the relevance of the physiological impairment in clinical decision making in the disease trajectory of oropharyngeal dysphagia.</li></ul><strong>PART II List of included Risk Factors (n = 43)</strong><br>Questions <sup>a,b</sup> (5-point ordinal scale)<ul><li>Rate the relevance of the risk factor in clinical decision making in the disease trajectory of oropharyngeal dysphagia.</li></ul><strong>PART III List of included Prognostic Factors (n = 39)</strong><br>Questions <sup>a,b</sup> (5-point ordinal scale)<ul><li>Rate the relevance of the prognostic factor in clinical decision making in the disease trajectory of oropharyngeal dysphagia.</li></ul><strong>PART IV List of all included factors (i.e., physiological impairments, risk factors, and prognostic factors) as agreed on during Round I and II (n = 50)</strong><br>Question<ul><li>Select and rank up to ten factors that most contribute to the severity of oropharyngeal dysphagia.</li></ul></td><td><strong>FACTORS Included: Agreement <sup>b</sup></strong><ul><li>Physiological Impairments (n = 10)</li><li>Risk Factor (n = 23)</li><li>Prognostic Factor (n = 20)</li></ul><strong>FACTORS Excluded: No agreement <sup>b</sup></strong><ul><li>Physiological Impairments (n = 11)</li><li>Risk Factor (n = 21)</li><li>Prognostic Factor (n = 18)</li></ul></td></tr><tr><td>Round III (N = 69)</td><td></td><td></td></tr></tbody></table>

### 3.2.1. Delphi Round I

The first Delphi round included: (1) a list of 22 items of potential physiological impairments, risk factors and prognostic factors (Part I), and (2) an additional 22 items of potential risk factors and prognostic factors only (Part II). Participants were asked to rate

<footnote><sup>a</sup> If 'Disagree' or 'Strongly disagree', changes can be suggested in comment boxes. <sup>b</sup> Consensus agreement is defined as ≥75% of participants rating 'Strongly agree' or 'Agree'.</footnote>
the importance of a factor as a physiological impairment contributing to inefficient and/or unsafe swallowing, a risk factor for the development of complications from oropharyngeal dysphagia, and/or a prognostic factor for treatment outcome or oropharyngeal dysphagia and/or underlying etiology. A total of 12 physiological impairments, 28 risk factors and 26 prognostic factors were identified achieving consensus ratings of 75% or higher. Participants were also asked about the comprehensibility of the presented items (Part III), resulting in an additional list of potential factors: 18 physiological impairments, 23 risk factors and 23 prognostic factors. Further details can be found in Table 3 (column ‘Importance’, Delphi Round I) presenting an overview of all potential factors and percentage agreement ratings resulting in the exclusion (<75% agreement) or inclusion (≥75% agreement) of relevant factors.

### 3.2.2. Delphi Round II

The second Delphi round presented the carried-over new potential factors as suggested by the participants, using similar ‘importance’ rating scales. An additional total of nine physiological impairments, 15 risk factors and 13 prognostic factors were included based on participants’ agreement scores (Table 3 (column ‘Importance’, Delphi Round II). When asked about the comprehensiveness of all identified factors, no additional items were suggested by the participants.

### 3.2.3. Delphi Round III

The final, third Delphi round focused on the *relevance* of agreed factors as physiological impairments (Part I), risk factors (Part II) and prognostic factors (Part III) in clinical decision making in the disease trajectory of oropharyngeal dysphagia. A total of 10 physiological impairments (10/21), 23 risk factors (23/43) and 21 prognostic factors (21/39) were identified as relevant factors in the clinical decision-making process (≥75% agreement). Table 3 (column ‘Relevance’) provides an overview of all relevance ratings.

Finally, participants were asked to select up to ten factors that most contribute to the severity of oropharyngeal dysphagia from all included fifty factors (i.e., physiological impairments, risk factors, and prognostic factors) as agreed on during the previous Delphi rounds (Part IV). Individual participants’ ranks ranged between 1–10, with 10 representing the most contributing factor to the severity of oropharyngeal dysphagia. The final ranking of factors was based on sum ranks. The five factors achieving the highest sum ranks were ‘Aspiration’, ‘Incomplete ejection or failure to eject aspirated materials from the airways’, ‘Weak or absent cough’, ‘Choking’ and ‘Sensory deficits in oropharynx’. When determining the frequency of factors listed as most contributing to the severity of oropharyngeal dysphagia, 40.6 to 68.1% of participants included the five factors with the highest sum ranks also in their individual top ten rankings. Further details on ranking results are provided in Table 3 (columns ‘Rank’ and ‘Frequency top 10’).
the importance of a factor as a physiological impairment contributing to inefficient and/or unsafe swallowing, a risk factor for the development of complications from oropharyngeal dysphagia, and/or a prognostic factor for treatment outcome or oropharyngeal dysphagia and/or underlying etiology. A total of 12 physiological impairments, 28 risk factors and 26 prognostic factors were identified achieving consensus ratings of 75% or higher. Participants were also asked about the comprehensibility of the presented items (Part III), resulting in an additional list of potential factors: 18 physiological impairments, 23 risk factors and 23 prognostic factors. Further details can be found in Table 3 (column ‘Importance’, Delphi Round I) presenting an overview of all potential factors and percentage agreement ratings resulting in the exclusion (<75% agreement) or inclusion (≥75% agreement) of relevant factors.

### 3.2.2. Delphi Round II

The second Delphi round presented the carried-over new potential factors as suggested by the participants, using similar ‘importance’ rating scales. An additional total of nine physiological impairments, 15 risk factors and 13 prognostic factors were included based on participants’ agreement scores (Table 3 (column ‘Importance’, Delphi Round II). When asked about the comprehensiveness of all identified factors, no additional items were suggested by the participants.

### 3.2.3. Delphi Round III

The final, third Delphi round focused on the *relevance* of agreed factors as physiological impairments (Part I), risk factors (Part II) and prognostic factors (Part III) in clinical decision making in the disease trajectory of oropharyngeal dysphagia. A total of 10 physiological impairments (10/21), 23 risk factors (23/43) and 21 prognostic factors (21/39) were identified as relevant factors in the clinical decision-making process (≥75% agreement). Table 3 (column ‘Relevance’) provides an overview of all relevance ratings.

Finally, participants were asked to select up to ten factors that most contribute to the severity of oropharyngeal dysphagia from all included fifty factors (i.e., physiological impairments, risk factors, and prognostic factors) as agreed on during the previous Delphi rounds (Part IV). Individual participants’ ranks ranged between 1–10, with 10 representing the most contributing factor to the severity of oropharyngeal dysphagia. The final ranking of factors was based on sum ranks. The five factors achieving the highest sum ranks were ‘Aspiration’, ‘Incomplete ejection or failure to eject aspirated materials from the airways’, ‘Weak or absent cough’, ‘Choking’ and ‘Sensory deficits in oropharynx’. When determining the frequency of factors listed as most contributing to the severity of oropharyngeal dysphagia, 40.6 to 68.1% of participants included the five factors with the highest sum ranks also in their individual top ten rankings. Further details on ranking results are provided in Table 3 (columns ‘Rank’ and ‘Frequency top 10’).
<table><caption>**Table 3.** Importance, Relevance and Ranking: Importance of factors as physiological impairment, risk factor, and/or prognostic factor; Relevance of factors in clinical decision making in the disease trajectory of oropharyngeal dysphagia; and, ranking of factors that most contribute to the severity of oropharyngeal dysphagia.</caption><thead><tr><th rowspan="2">Item (Final Rank Order <sup>a</sup>)</th><th colspan="4">Importance <sup>b,c</sup> (% Agreement)</th><th colspan="4">Relevance <sup>c,d</sup> (% Agreement)</th><th colspan="3">Rank</th><th colspan="2">Frequency top 10 <sup>e</sup></th></tr><tr><th>Physiological Impairment</th><th>Risk Factor</th><th>Prognostic Factor</th><th>Delphi Round</th><th>Physiological Impairment</th><th>Risk Factor</th><th>Prognostic Factor</th><th>Final Rank <sup>f</sup></th><th>Sum Rank <sup>g</sup></th><th>Mean Rank <sup>h</sup></th><th>Freq.</th><th>%</th></tr></thead><tbody><tr><td>Aspiration</td><td>84.0</td><td>94.6</td><td>86.6</td><td>I</td><td>91.3</td><td>92.8</td><td>85.5</td><td>1</td><td>390</td><td>5.7</td><td>46</td><td>66.7%</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>93.3</td><td>98.6</td><td>89.4</td><td>I</td><td>98.6</td><td>92.8</td><td>85.5</td><td>2</td><td>357</td><td>5.2</td><td>47</td><td>68.1%</td></tr><tr><td>Weak or absent cough</td><td>94.7</td><td>100.0</td><td>89.4</td><td>I</td><td>85.7</td><td>91.3</td><td>87.0</td><td>3</td><td>344</td><td>5.0</td><td>44</td><td>63.8%</td></tr><tr><td>Choking</td><td>81.3</td><td>94.6</td><td>78.7</td><td>I</td><td>85.5</td><td>88.4</td><td>78.3</td><td>4</td><td>204</td><td>3.0</td><td>28</td><td>40.6%</td></tr><tr><td>Sensory deficits in oropharynx</td><td>96.0</td><td>97.3</td><td>88.0</td><td>I</td><td>78.3</td><td>79.7</td><td>76.8</td><td>5</td><td>187</td><td>2.7</td><td>36</td><td>52.2%</td></tr><tr><td>Poor oromotor functioning/skills (e.g., tongue, lip and velum)</td><td>97.3</td><td>81.3</td><td>81.4</td><td>I</td><td>86.9</td><td>71.0</td><td>63.7</td><td>6</td><td>182</td><td>2.6</td><td>26</td><td>37.7%</td></tr><tr><td>Recurrent pulmonary infections</td><td>N.A.</td><td>90.6</td><td>90.7</td><td>I</td><td>N.A.</td><td>88.4</td><td>84.1</td><td>7</td><td>151</td><td>2.2</td><td>30</td><td>43.5%</td></tr><tr><td>Poor respiratory status, pulmonary infection or pulmonary disease (e.g., COPD)</td><td>81.3</td><td>93.3</td><td>89.3</td><td>I</td><td>73.9</td><td>78.3</td><td>82.6</td><td>8</td><td>136</td><td>2.0</td><td>28</td><td>40.6%</td></tr><tr><td>Progress and severity of underlying disease</td><td>83.8</td><td>90.3</td><td>95.2</td><td>II</td><td>72.1</td><td>81.1</td><td>95.6</td><td>9</td><td>123</td><td>1.8</td><td>21</td><td>30.4%</td></tr><tr><td>Presence of residue</td><td>78.7</td><td>85.4</td><td>70.7</td><td>I</td><td>71.0</td><td>75.3</td><td>N.A.</td><td>10</td><td>116</td><td>1.7</td><td>23</td><td>33.3%</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills Insufficient or inadequate oral intake (e.g., caloric intake, consistency, nutritional supplements)</td><td>96.8</td><td>95.2</td><td>93.6</td><td>II</td><td>94.2</td><td>85.5</td><td>78.2</td><td>11</td><td>113</td><td>1.6</td><td>24</td><td>34.8%</td></tr><tr><td>Malnutrition</td><td>52.0</td><td>85.4</td><td>81.3</td><td>I</td><td>N.A.</td><td>78.2</td><td>75.3</td><td>12</td><td>107</td><td>1.6</td><td>19</td><td>27.5%</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>64.0</td><td>93.3</td><td>92.0</td><td>I</td><td>N.A.</td><td>78.2</td><td>79.7</td><td>13</td><td>106</td><td>1.5</td><td>18</td><td>26.1%</td></tr><tr><td>Frailty</td><td>N.A.</td><td>93.3</td><td>86.6</td><td>I</td><td>N.A.</td><td>66.6</td><td>75.4</td><td>15</td><td>81</td><td>1.2</td><td>17</td><td>24.6%</td></tr><tr><td>Poor oral hygiene</td><td>N.A.</td><td>92.0</td><td>81.3</td><td>I</td><td>N.A.</td><td>75.4</td><td>66.6</td><td>16</td><td>74</td><td>1.1</td><td>14</td><td>20.3%</td></tr><tr><td>Sarcopenia</td><td>92.0</td><td>90.6</td><td>93.3</td><td>I</td><td>58.1</td><td>69.5</td><td>71.0</td><td>17</td><td>72</td><td>1.0</td><td>13</td><td>18.8%</td></tr><tr><td>Impaired cognitive functioning</td><td>N.A.</td><td>90.7</td><td>89.4</td><td>I</td><td>N.A.</td><td>81.1</td><td>84.0</td><td>18</td><td>68</td><td>1.0</td><td>17</td><td>24.6%</td></tr><tr><td>Dehydration</td><td>N.A.</td><td>90.7</td><td>85.4</td><td>I</td><td>N.A.</td><td>76.8</td><td>73.9</td><td>19</td><td>65</td><td>0.9</td><td>13</td><td>18.8%</td></tr><tr><td>Anatomical/Physiological abnormalities</td><td>87.1</td><td>83.9</td><td>82.3</td><td>II</td><td>75.3</td><td>63.7</td><td>66.6</td><td>20</td><td>60</td><td>0.9</td><td>12</td><td>17.4%</td></tr><tr><td>Tracheostomy and/or ventilation support</td><td>87.1</td><td>85.5</td><td>75.8</td><td>II</td><td>76.8</td><td>79.7</td><td>71.0</td><td>21</td><td>57</td><td>0.8</td><td>12</td><td>17.4%</td></tr><tr><td>Unawareness of the swallowing disorder (i.e., anosognosia)</td><td>N.A.</td><td>90.7</td><td>92.0</td><td>I</td><td>N.A.</td><td>82.6</td><td>81.2</td><td>22</td><td>52</td><td>0.8</td><td>13</td><td>18.8%</td></tr><tr><td>Wet/gurgly voice</td><td>N.A.</td><td>85.5</td><td>79.0</td><td>II</td><td>N.A.</td><td>73.9</td><td>63.8</td><td>23</td><td>50</td><td>0.7</td><td>11</td><td>15.9%</td></tr><tr><td>Lack of skilled clinicians to manage and/or care for oropharyngeal dysphagia</td><td>56.5</td><td>96.8</td><td>86.7</td><td>II</td><td>N.A.</td><td>85.5</td><td>90.9</td><td>24</td><td>47</td><td>0.7</td><td>11</td><td>15.9%</td></tr><tr><td>Nonadherence to treatment and medical recommendations</td><td>N.A.</td><td>81.3</td><td>82.7</td><td>I</td><td>N.A.</td><td>72.4</td><td>84.0</td><td>25</td><td>42</td><td>0.6</td><td>11</td><td>15.9%</td></tr><tr><td>Respiratory difficulties</td><td>92.0</td><td>75.1</td><td>88.7</td><td>II</td><td>71.0</td><td>73.9</td><td>78.3</td><td>26</td><td>36</td><td>0.5</td><td>6</td><td>8.7%</td></tr><tr><td>No or limited assessment for oropharyngeal dysphagia</td><td>N.A.</td><td>94.7</td><td>94.6</td><td>I</td><td>N.A.</td><td>84.0</td><td>75.4</td><td>27</td><td>35</td><td>0.5</td><td>9</td><td>13.0%</td></tr><tr><td>Lack of screening for oropharyngeal dysphagia</td><td>N.A.</td><td>89.3</td><td>73.3</td><td>I</td><td>N.A.</td><td>75.4</td><td>N.A.</td><td>28</td><td>31</td><td>0.4</td><td>6</td><td>8.7%</td></tr></tbody></table>
<table><caption>**Table 3.** Importance, Relevance and Ranking: Importance of factors as physiological impairment, risk factor, and/or prognostic factor; Relevance of factors in clinical decision making in the disease trajectory of oropharyngeal dysphagia; and, ranking of factors that most contribute to the severity of oropharyngeal dysphagia.</caption><thead><tr><th rowspan="2">Item (Final Rank Order <sup>a</sup>)</th><th colspan="4">Importance <sup>b,c</sup> (% Agreement)</th><th colspan="4">Relevance <sup>c,d</sup> (% Agreement)</th><th colspan="3">Rank</th><th colspan="2">Frequency top 10 <sup>e</sup></th></tr><tr><th>Physiological Impairment</th><th>Risk Factor</th><th>Prognostic Factor</th><th>Delphi Round</th><th>Physiological Impairment</th><th>Risk Factor</th><th>Prognostic Factor</th><th>Final Rank <sup>f</sup></th><th>Sum Rank <sup>g</sup></th><th>Mean Rank <sup>h</sup></th><th>Freq.</th><th>%</th></tr></thead><tbody><tr><td>Aspiration</td><td>84.0</td><td>94.6</td><td>86.6</td><td>I</td><td>91.3</td><td>92.8</td><td>85.5</td><td>1</td><td>390</td><td>5.7</td><td>46</td><td>66.7%</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>93.3</td><td>98.6</td><td>89.4</td><td>I</td><td>98.6</td><td>92.8</td><td>85.5</td><td>2</td><td>357</td><td>5.2</td><td>47</td><td>68.1%</td></tr><tr><td>Weak or absent cough</td><td>94.7</td><td>100.0</td><td>89.4</td><td>I</td><td>85.7</td><td>91.3</td><td>87.0</td><td>3</td><td>344</td><td>5.0</td><td>44</td><td>63.8%</td></tr><tr><td>Choking</td><td>81.3</td><td>94.6</td><td>78.7</td><td>I</td><td>85.5</td><td>88.4</td><td>78.3</td><td>4</td><td>204</td><td>3.0</td><td>28</td><td>40.6%</td></tr><tr><td>Sensory deficits in oropharynx</td><td>96.0</td><td>97.3</td><td>88.0</td><td>I</td><td>78.3</td><td>79.7</td><td>76.8</td><td>5</td><td>187</td><td>2.7</td><td>36</td><td>52.2%</td></tr><tr><td>Poor oromotor functioning/skills (e.g., tongue, lip and velum)</td><td>97.3</td><td>81.3</td><td>81.4</td><td>I</td><td>86.9</td><td>71.0</td><td>63.7</td><td>6</td><td>182</td><td>2.6</td><td>26</td><td>37.7%</td></tr><tr><td>Recurrent pulmonary infections</td><td>N.A.</td><td>90.6</td><td>90.7</td><td>I</td><td>N.A.</td><td>88.4</td><td>84.1</td><td>7</td><td>151</td><td>2.2</td><td>30</td><td>43.5%</td></tr><tr><td>Poor respiratory status, pulmonary infection or pulmonary disease (e.g., COPD)</td><td>81.3</td><td>93.3</td><td>89.3</td><td>I</td><td>73.9</td><td>78.3</td><td>82.6</td><td>8</td><td>136</td><td>2.0</td><td>28</td><td>40.6%</td></tr><tr><td>Progress and severity of underlying disease</td><td>83.8</td><td>90.3</td><td>95.2</td><td>II</td><td>72.1</td><td>81.1</td><td>95.6</td><td>9</td><td>123</td><td>1.8</td><td>21</td><td>30.4%</td></tr><tr><td>Presence of residue</td><td>78.7</td><td>85.4</td><td>70.7</td><td>I</td><td>71.0</td><td>75.3</td><td>N.A.</td><td>10</td><td>116</td><td>1.7</td><td>23</td><td>33.3%</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills Insufficient or inadequate oral intake (e.g., caloric intake, consistency, nutritional supplements)</td><td>96.8</td><td>95.2</td><td>93.6</td><td>II</td><td>94.2</td><td>85.5</td><td>78.2</td><td>11</td><td>113</td><td>1.6</td><td>24</td><td>34.8%</td></tr><tr><td>Malnutrition</td><td>52.0</td><td>85.4</td><td>81.3</td><td>I</td><td>N.A.</td><td>78.2</td><td>75.3</td><td>12</td><td>107</td><td>1.6</td><td>19</td><td>27.5%</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>64.0</td><td>93.3</td><td>92.0</td><td>I</td><td>N.A.</td><td>78.2</td><td>79.7</td><td>13</td><td>106</td><td>1.5</td><td>18</td><td>26.1%</td></tr><tr><td>Frailty</td><td>88.7</td><td>96.7</td><td>93.5</td><td>II</td><td>92.8</td><td>86.9</td><td>89.9</td><td>14</td><td>105</td><td>1.5</td><td>15</td><td>21.7%</td></tr><tr><td>Poor oral hygiene</td><td>N.A.</td><td>93.3</td><td>86.6</td><td>I</td><td>N.A.</td><td>66.6</td><td>75.4</td><td>15</td><td>81</td><td>1.2</td><td>17</td><td>24.6%</td></tr><tr><td>Sarcopenia</td><td>N.A.</td><td>92.0</td><td>81.3</td><td>I</td><td>N.A.</td><td>75.4</td><td>66.6</td><td>16</td><td>74</td><td>1.1</td><td>14</td><td>20.3%</td></tr><tr><td>Impaired cognitive functioning</td><td>N.A.</td><td>90.6</td><td>93.3</td><td>I</td><td>58.1</td><td>69.5</td><td>71.0</td><td>17</td><td>72</td><td>1.0</td><td>13</td><td>18.8%</td></tr><tr><td>Dehydration</td><td>N.A.</td><td>90.7</td><td>89.4</td><td>I</td><td>N.A.</td><td>81.1</td><td>84.0</td><td>18</td><td>68</td><td>1.0</td><td>17</td><td>24.6%</td></tr><tr><td>Anatomical/Physiological abnormalities</td><td>87.1</td><td>83.9</td><td>82.3</td><td>II</td><td>75.3</td><td>63.7</td><td>66.6</td><td>20</td><td>60</td><td>0.9</td><td>12</td><td>17.4%</td></tr><tr><td>Tracheostomy and/or ventilation support</td><td>87.1</td><td>85.5</td><td>75.8</td><td>II</td><td>76.8</td><td>79.7</td><td>71.0</td><td>21</td><td>57</td><td>0.8</td><td>12</td><td>17.4%</td></tr><tr><td>Unawareness of the swallowing disorder (i.e., anosognosia)</td><td>N.A.</td><td>90.7</td><td>92.0</td><td>I</td><td>N.A.</td><td>82.6</td><td>81.2</td><td>22</td><td>52</td><td>0.8</td><td>13</td><td>18.8%</td></tr><tr><td>Wet/gurgly voice</td><td>N.A.</td><td>85.5</td><td>79.0</td><td>II</td><td>N.A.</td><td>73.9</td><td>63.8</td><td>23</td><td>50</td><td>0.7</td><td>11</td><td>15.9%</td></tr><tr><td>Lack of skilled clinicians to manage and/or care for oropharyngeal dysphagia</td><td>56.5</td><td>96.8</td><td>86.7</td><td>II</td><td>N.A.</td><td>85.5</td><td>90.9</td><td>24</td><td>47</td><td>0.7</td><td>11</td><td>15.9%</td></tr><tr><td>Nonadherence to treatment and medical recommendations</td><td>N.A.</td><td>81.3</td><td>82.7</td><td>I</td><td>N.A.</td><td>72.4</td><td>84.0</td><td>25</td><td>42</td><td>0.6</td><td>11</td><td>15.9%</td></tr><tr><td>Respiratory difficulties</td><td>92.0</td><td>75.1</td><td>88.7</td><td>II</td><td>71.0</td><td>73.9</td><td>78.3</td><td>26</td><td>36</td><td>0.5</td><td>6</td><td>8.7%</td></tr><tr><td>No or limited assessment for oropharyngeal dysphagia</td><td>N.A.</td><td>94.7</td><td>94.6</td><td>I</td><td>N.A.</td><td>84.0</td><td>75.4</td><td>27</td><td>35</td><td>0.5</td><td>9</td><td>13.0%</td></tr><tr><td>Lack of screening for oropharyngeal dysphagia</td><td>N.A.</td><td>89.3</td><td>73.3</td><td>I</td><td>N.A.</td><td>75.4</td><td>N.A.</td><td>28</td><td>31</td><td>0.4</td><td>6</td><td>8.7%</td></tr></tbody></table>
<table><caption>Table 3. *Cont.*</caption><thead><tr><th rowspan="2">Item (Final Rank Order <sup>a</sup>)</th><th colspan="3">Importance <sup>b,c</sup> (% Agreement)</th><th colspan="4">Relevance <sup>c,d</sup> (% Agreement)</th><th colspan="3">Rank</th><th colspan="2">Frequency top 10 <sup>e</sup></th></tr><tr><th>Physiological Impairment</th><th>Risk Factor</th><th>Prognostic Factor</th><th>Delphi Round</th><th>Physiological Impairment</th><th>Risk Factor</th><th>Prognostic Factor</th><th>Final Rank <sup>f</sup></th><th>Sum Rank <sup>g</sup></th><th>Mean Rank <sup>h</sup></th><th>Freq.</th><th>%</th></tr></thead><tbody><tr><td>Caregiver dependence when eating (no or limited self-feeding skills)</td><td>N.A.</td><td>85.3</td><td>81.3</td><td>I</td><td>N.A.</td><td>72.5</td><td>71.0</td><td>29</td><td>31</td><td>0.4</td><td>12</td><td>17.4%</td></tr><tr><td>Poor dental status</td><td>74.6</td><td>78.7</td><td>64.0</td><td>I</td><td>N.A.</td><td>47.8</td><td>N.A.</td><td>30</td><td>29</td><td>0.4</td><td>5</td><td>7.2%</td></tr><tr><td>Comorbidities (e.g., diabetes, COPD)</td><td>61.3</td><td>80.0</td><td>76.0</td><td>I</td><td>N.A.</td><td>59.4</td><td>71.0</td><td>31</td><td>27</td><td>0.4</td><td>7</td><td>10.1%</td></tr><tr><td>Drooling (i.e., sialorrhea)</td><td>78.7</td><td>66.7</td><td>54.7</td><td>I</td><td>43.4</td><td>N.A.</td><td>N.A.</td><td>32</td><td>26</td><td>0.4</td><td>5</td><td>7.2%</td></tr><tr><td>Chronicity of dysphagia</td><td>N.A.</td><td>87.1</td><td>88.7</td><td>II</td><td>N.A.</td><td>75.3</td><td>72.4</td><td>33</td><td>25</td><td>0.4</td><td>4</td><td>5.8%</td></tr><tr><td>Esophageal dysfunction or disease (e.g., reflux or GERD), or more general digestive problems</td><td>74.6</td><td>81.4</td><td>66.7</td><td>I</td><td>N.A.</td><td>53.6</td><td>N.A.</td><td>34</td><td>24</td><td>0.3</td><td>5</td><td>7.2%</td></tr><tr><td>Problems associated with head and body positioning (e.g., unable to support posture)</td><td>86.6</td><td>94.7</td><td>84.0</td><td>I</td><td>60.9</td><td>59.4</td><td>57.9</td><td>35</td><td>24</td><td>0.3</td><td>8</td><td>11.6%</td></tr><tr><td>Lack of social network/support (i.e., caregiver and family)</td><td>N.A.</td><td>64.0</td><td>77.3</td><td>I</td><td>N.A.</td><td>N.A.</td><td>81.1</td><td>36</td><td>23</td><td>0.3</td><td>7</td><td>10.1%</td></tr><tr><td>Xerostomia</td><td>88.7</td><td>74.2</td><td>69.4</td><td>II</td><td>43.4</td><td>N.A.</td><td>N.A.</td><td>37</td><td>19</td><td>0.3</td><td>4</td><td>5.8%</td></tr><tr><td>Poor mastication (not related to dentures)</td><td>85.5</td><td>75.8</td><td>56.5</td><td>II</td><td>58.0</td><td>49.3</td><td>N.A.</td><td>38</td><td>19</td><td>0.3</td><td>4</td><td>5.8%</td></tr><tr><td>Short attention span and/or poor memory</td><td>N.A.</td><td>58.0</td><td>78.7</td><td>I</td><td>N.A.</td><td>N.A.</td><td>69.6</td><td>39</td><td>18</td><td>0.3</td><td>5</td><td>7.2%</td></tr><tr><td>Lack of resources (e.g., adapted cutlery, special needs wheelchair, texture modified food)</td><td>N.A.</td><td>82.7</td><td>85.3</td><td>I</td><td>N.A.</td><td>66.7</td><td>71.0</td><td>40</td><td>15</td><td>0.2</td><td>6</td><td>8.7%</td></tr><tr><td>Apraxia</td><td>77.4</td><td>66.6</td><td>68.0</td><td>I</td><td>44.9</td><td>N.A.</td><td>N.A.</td><td>41</td><td>14</td><td>0.2</td><td>4</td><td>5.8%</td></tr><tr><td>Prolonged mealtime duration</td><td>62.9</td><td>74.2</td><td>75.8</td><td>II</td><td>N.A.</td><td>N.A.</td><td>50.7</td><td>42</td><td>13</td><td>0.2</td><td>6</td><td>8.7%</td></tr><tr><td>No or limited follow-up of people with oropharyngeal dysphagia</td><td>N.A.</td><td>92.0</td><td>90.7</td><td>I</td><td>N.A.</td><td>82.6</td><td>81.2</td><td>43</td><td>12</td><td>0.2</td><td>4</td><td>5.8%</td></tr><tr><td>Poor patient self-reported Functional Health Status (FHS)</td><td>53.3</td><td>77.3</td><td>86.7</td><td>I</td><td>N.A.</td><td>47.8</td><td>55.1</td><td>44</td><td>12</td><td>0.2</td><td>3</td><td>4.3%</td></tr><tr><td>Movement disorders</td><td>N.A.</td><td>82.2</td><td>80.6</td><td>II</td><td>N.A.</td><td>55.0</td><td>60.9</td><td>45</td><td>10</td><td>0.1</td><td>3</td><td>4.3%</td></tr><tr><td>Living environment (e.g., independent living, hospital, rehabilitation, nursing home)</td><td>N.A.</td><td>83.9</td><td>83.9</td><td>II</td><td>N.A.</td><td>56.5</td><td>68.1</td><td>46</td><td>9</td><td>0.1</td><td>2</td><td>2.9%</td></tr><tr><td>Delayed oral transit time</td><td>85.5</td><td>72.5</td><td>71.0</td><td>II</td><td>47.8</td><td>N.A.</td><td>N.A.</td><td>47</td><td>8</td><td>0.1</td><td>2</td><td>2.9%</td></tr><tr><td>Bedridden</td><td>61.3</td><td>82.2</td><td>72.5</td><td>II</td><td>N.A.</td><td>65.2</td><td>N.A.</td><td>48</td><td>4</td><td>0.1</td><td>2</td><td>2.9%</td></tr><tr><td>Poor self-feeding skills</td><td>71.0</td><td>83.9</td><td>80.6</td><td>II</td><td>N.A.</td><td>69.6</td><td>62.3</td><td>49</td><td>3</td><td>0.0</td><td>1</td><td>1.4%</td></tr><tr><td>Infections of the oral cavity, naso, oro and/or hypopharynx</td><td>70.9</td><td>77.4</td><td>66.2</td><td>II</td><td>N.A.</td><td>63.6</td><td>N.A.</td><td>50</td><td>2</td><td>0.0</td><td>1</td><td>1.4%</td></tr><tr><td>Advanced age</td><td>N.A.</td><td>74.7</td><td>64.7</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Aphasia and/or poor communication skills</td><td>43.6</td><td>41.9</td><td>53.2</td><td>II</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Behavioural/psychological eating disorders (e.g., anorexia, picky eaters, binge eating)</td><td>N.A.</td><td>58.0</td><td>50.7</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Dependence in activities of daily living (ADL)</td><td>N.A.</td><td>69.3</td><td>70.6</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Depression</td><td>N.A.</td><td>45.3</td><td>66.7</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Dysarthria</td><td>59.6</td><td>50.0</td><td>54.8</td><td>II</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr></tbody></table>
<table><caption>Table 3. *Cont.*</caption><thead><tr><th rowspan="2">Item (Final Rank Order <sup>a</sup>)</th><th colspan="3">Importance <sup>b,c</sup> (% Agreement)</th><th colspan="4">Relevance <sup>c,d</sup> (% Agreement)</th><th colspan="3">Rank</th><th colspan="2">Frequency top 10 <sup>e</sup></th></tr><tr><th>Physiological Impairment</th><th>Risk Factor</th><th>Prognostic Factor</th><th>Delphi Round</th><th>Physiological Impairment</th><th>Risk Factor</th><th>Prognostic Factor</th><th>Final Rank <sup>f</sup></th><th>Sum Rank <sup>g</sup></th><th>Mean Rank <sup>h</sup></th><th>Freq.</th><th>%</th></tr></thead><tbody><tr><td>Caregiver dependence when eating (no or limited self-feeding skills)</td><td>N.A.</td><td>85.3</td><td>81.3</td><td>I</td><td>N.A.</td><td>72.5</td><td>71.0</td><td>29</td><td>31</td><td>0.4</td><td>12</td><td>17.4%</td></tr><tr><td>Poor dental status</td><td>74.6</td><td>78.7</td><td>64.0</td><td>I</td><td>N.A.</td><td>47.8</td><td>N.A.</td><td>30</td><td>29</td><td>0.4</td><td>5</td><td>7.2%</td></tr><tr><td>Comorbidities (e.g., diabetes, COPD)</td><td>61.3</td><td>80.0</td><td>76.0</td><td>I</td><td>N.A.</td><td>59.4</td><td>71.0</td><td>31</td><td>27</td><td>0.4</td><td>7</td><td>10.1%</td></tr><tr><td>Drooling (i.e., sialorrhea)</td><td>78.7</td><td>66.7</td><td>54.7</td><td>I</td><td>43.4</td><td>N.A.</td><td>N.A.</td><td>32</td><td>26</td><td>0.4</td><td>5</td><td>7.2%</td></tr><tr><td>Chronicity of dysphagia</td><td>N.A.</td><td>87.1</td><td>88.7</td><td>II</td><td>N.A.</td><td>75.3</td><td>72.4</td><td>33</td><td>25</td><td>0.4</td><td>4</td><td>5.8%</td></tr><tr><td>Esophageal dysfunction or disease (e.g., reflux or GERD), or more general digestive problems</td><td>74.6</td><td>81.4</td><td>66.7</td><td>I</td><td>N.A.</td><td>53.6</td><td>N.A.</td><td>34</td><td>24</td><td>0.3</td><td>5</td><td>7.2%</td></tr><tr><td>Problems associated with head and body positioning (e.g., unable to support posture)</td><td>86.6</td><td>94.7</td><td>84.0</td><td>I</td><td>60.9</td><td>59.4</td><td>57.9</td><td>35</td><td>24</td><td>0.3</td><td>8</td><td>11.6%</td></tr><tr><td>Lack of social network/support (i.e., caregiver and family)</td><td>N.A.</td><td>64.0</td><td>77.3</td><td>I</td><td>N.A.</td><td>N.A.</td><td>81.1</td><td>36</td><td>23</td><td>0.3</td><td>7</td><td>10.1%</td></tr><tr><td>Xerostomia</td><td>88.7</td><td>74.2</td><td>69.4</td><td>II</td><td>43.4</td><td>N.A.</td><td>N.A.</td><td>37</td><td>19</td><td>0.3</td><td>4</td><td>5.8%</td></tr><tr><td>Poor mastication (not related to dentures)</td><td>85.5</td><td>75.8</td><td>56.5</td><td>II</td><td>58.0</td><td>49.3</td><td>N.A.</td><td>38</td><td>19</td><td>0.3</td><td>4</td><td>5.8%</td></tr><tr><td>Short attention span and/or poor memory</td><td>N.A.</td><td>58.0</td><td>78.7</td><td>I</td><td>N.A.</td><td>N.A.</td><td>69.6</td><td>39</td><td>18</td><td>0.3</td><td>5</td><td>7.2%</td></tr><tr><td>Lack of resources (e.g., adapted cutlery, special needs wheelchair, texture modified food)</td><td>N.A.</td><td>82.7</td><td>85.3</td><td>I</td><td>N.A.</td><td>66.7</td><td>71.0</td><td>40</td><td>15</td><td>0.2</td><td>6</td><td>8.7%</td></tr><tr><td>Apraxia</td><td>77.4</td><td>66.6</td><td>68.0</td><td>I</td><td>44.9</td><td>N.A.</td><td>N.A.</td><td>41</td><td>14</td><td>0.2</td><td>4</td><td>5.8%</td></tr><tr><td>Prolonged mealtime duration</td><td>62.9</td><td>74.2</td><td>75.8</td><td>II</td><td>N.A.</td><td>N.A.</td><td>50.7</td><td>42</td><td>13</td><td>0.2</td><td>6</td><td>8.7%</td></tr><tr><td>No or limited follow-up of people with oropharyngeal dysphagia</td><td>N.A.</td><td>92.0</td><td>90.7</td><td>I</td><td>N.A.</td><td>82.6</td><td>81.2</td><td>43</td><td>12</td><td>0.2</td><td>4</td><td>5.8%</td></tr><tr><td>Poor patient self-reported Functional Health Status (FHS)</td><td>53.3</td><td>77.3</td><td>86.7</td><td>I</td><td>N.A.</td><td>47.8</td><td>55.1</td><td>44</td><td>12</td><td>0.2</td><td>3</td><td>4.3%</td></tr><tr><td>Movement disorders</td><td>N.A.</td><td>82.2</td><td>80.6</td><td>II</td><td>N.A.</td><td>55.0</td><td>60.9</td><td>45</td><td>10</td><td>0.1</td><td>3</td><td>4.3%</td></tr><tr><td>Living environment (e.g., independent living, hospital, rehabilitation, nursing home)</td><td>N.A.</td><td>83.9</td><td>83.9</td><td>II</td><td>N.A.</td><td>56.5</td><td>68.1</td><td>46</td><td>9</td><td>0.1</td><td>2</td><td>2.9%</td></tr><tr><td>Delayed oral transit time</td><td>85.5</td><td>72.5</td><td>71.0</td><td>II</td><td>47.8</td><td>N.A.</td><td>N.A.</td><td>47</td><td>8</td><td>0.1</td><td>2</td><td>2.9%</td></tr><tr><td>Bedridden</td><td>61.3</td><td>82.2</td><td>72.5</td><td>II</td><td>N.A.</td><td>65.2</td><td>N.A.</td><td>48</td><td>4</td><td>0.1</td><td>2</td><td>2.9%</td></tr><tr><td>Poor self-feeding skills</td><td>71.0</td><td>83.9</td><td>80.6</td><td>II</td><td>N.A.</td><td>69.6</td><td>62.3</td><td>49</td><td>3</td><td>0.0</td><td>1</td><td>1.4%</td></tr><tr><td>Infections of the oral cavity, naso, oro and/or hypopharynx</td><td>70.9</td><td>77.4</td><td>66.2</td><td>II</td><td>N.A.</td><td>63.6</td><td>N.A.</td><td>50</td><td>2</td><td>0.0</td><td>1</td><td>1.4%</td></tr><tr><td>Advanced age</td><td>N.A.</td><td>74.7</td><td>64.7</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Aphasia and/or poor communication skills</td><td>43.6</td><td>41.9</td><td>53.2</td><td>II</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Behavioural/psychological eating disorders (e.g., anorexia, picky eaters, binge eating)</td><td>N.A.</td><td>58.0</td><td>50.7</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Dependence in activities of daily living (ADL)</td><td>N.A.</td><td>69.3</td><td>70.6</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Depression</td><td>N.A.</td><td>45.3</td><td>66.7</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Dysarthria</td><td>59.6</td><td>50.0</td><td>54.8</td><td>II</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr></tbody></table>
<table><caption>Table 3. *Cont.*</caption><thead><tr><th rowspan="2">Item (Final Rank Order <sup>a</sup>)</th><th colspan="3">Importance <sup>b,c</sup> (% Agreement)</th><th colspan="5">Relevance <sup>c,d</sup> (% Agreement)</th><th colspan="2">Rank</th><th colspan="2">Frequency top 10 <sup>e</sup></th></tr><tr><th>Physiological Impairment</th><th>Risk Factor</th><th>Prognostic Factor</th><th>Delphi Round</th><th>Physiological Impairment</th><th>Risk Factor</th><th>Prognostic Factor</th><th>Final Rank <sup>f</sup></th><th>Sum Rank <sup>g</sup></th><th>Mean Rank <sup>h</sup></th><th>Freq.</th><th>%</th></tr></thead><tbody><tr><td>Dysphonia</td><td>42.0</td><td>48.4</td><td>43.5</td><td>II</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Geographical isolation (no or limited access to support)</td><td>N.A.</td><td>58.7</td><td>66.7</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Inappropriate impulsive behaviour</td><td>53.3</td><td>68.0</td><td>62.7</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Lack of inhibitory control on food intake</td><td>57.4</td><td>73.3</td><td>64.0</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Loss of appetite</td><td>30.6</td><td>66.7</td><td>57.3</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>No or limited supervision during mealtimes</td><td>N.A.</td><td>65.3</td><td>62.6</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Orofacial, laryngeal and/or pharyngeal pain</td><td>74.2</td><td>58.1</td><td>66.2</td><td>II</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Penetration</td><td>68.0</td><td>70.7</td><td>61.4</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Polypharmacy</td><td>N.A.</td><td>72.6</td><td>67.7</td><td>II</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Social isolation</td><td>N.A.</td><td>60.0</td><td>70.6</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Tube feeding</td><td>N.A.</td><td>66.7</td><td>69.4</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr></tbody></table>

Note. N.A. (grey background) = Not Applicable. <sup>a</sup> Items ordered as per final ranks. Items not considered important physiological impairments, risk factors or prognostic factors are listed in alphabetical order at the end of the table. <sup>b</sup> Importance of factors as physiological impairment, risk factor, and/or prognostic factor. <sup>c</sup> Data in bold italic: % Agreement ≥ 75% (Agree or Strongly Agree). <sup>d</sup> Relevance of factors (i.e., physiological impairment, risk factor, and/or prognostic factor) in clinical decision making in the disease trajectory of oropharyngeal dysphagia. <sup>e</sup> Frequency of items being included in the top ten factors that most contribute to the severity of oropharyngeal dysphagia (N<sub>Total</sub> = 69). <sup>f</sup> Rank order based on sum of all ranks. <sup>g</sup> Sum of all participants' ranks (N<sub>Total</sub> = 69); individual participants' ranks ranging between 1–10 (with 10 representing the most contributing factor to the severity of oropharyngeal dysphagia). <sup>h</sup> Mean of all participants' ranks (N<sub>Total</sub> = 69).
<table><caption>Table 3. *Cont.*</caption><thead><tr><th rowspan="2">Item (Final Rank Order <sup>a</sup>)</th><th colspan="3">Importance <sup>b,c</sup> (% Agreement)</th><th colspan="5">Relevance <sup>c,d</sup> (% Agreement)</th><th colspan="2">Rank</th><th colspan="2">Frequency top 10 <sup>e</sup></th></tr><tr><th>Physiological Impairment</th><th>Risk Factor</th><th>Prognostic Factor</th><th>Delphi Round</th><th>Physiological Impairment</th><th>Risk Factor</th><th>Prognostic Factor</th><th>Final Rank <sup>f</sup></th><th>Sum Rank <sup>g</sup></th><th>Mean Rank <sup>h</sup></th><th>Freq.</th><th>%</th></tr></thead><tbody><tr><td>Dysphonia</td><td>42.0</td><td>48.4</td><td>43.5</td><td>II</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Geographical isolation (no or limited access to support)</td><td>N.A.</td><td>58.7</td><td>66.7</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Inappropriate impulsive behaviour</td><td>53.3</td><td>68.0</td><td>62.7</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Lack of inhibitory control on food intake</td><td>57.4</td><td>73.3</td><td>64.0</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Loss of appetite</td><td>30.6</td><td>66.7</td><td>57.3</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>No or limited supervision during mealtimes</td><td>N.A.</td><td>65.3</td><td>62.6</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Orofacial, laryngeal and/or pharyngeal pain</td><td>74.2</td><td>58.1</td><td>66.2</td><td>II</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Penetration</td><td>68.0</td><td>70.7</td><td>61.4</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Polypharmacy</td><td>N.A.</td><td>72.6</td><td>67.7</td><td>II</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Social isolation</td><td>N.A.</td><td>60.0</td><td>70.6</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr><tr><td>Tube feeding</td><td>N.A.</td><td>66.7</td><td>69.4</td><td>I</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td><td>N.A.</td></tr></tbody></table>

Note. N.A. (grey background) = Not Applicable. <sup>a</sup> Items ordered as per final ranks. Items not considered important physiological impairments, risk factors or prognostic factors are listed in alphabetical order at the end of the table. <sup>b</sup> Importance of factors as physiological impairment, risk factor, and/or prognostic factor. <sup>c</sup> Data in bold italic: % Agreement ≥ 75% (Agree or Strongly Agree). <sup>d</sup> Relevance of factors (i.e., physiological impairment, risk factor, and/or prognostic factor) in clinical decision making in the disease trajectory of oropharyngeal dysphagia. <sup>e</sup> Frequency of items being included in the top ten factors that most contribute to the severity of oropharyngeal dysphagia (N<sub>Total</sub> = 69). <sup>f</sup> Rank order based on sum of all ranks. <sup>g</sup> Sum of all participants' ranks (N<sub>Total</sub> = 69); individual participants' ranks ranging between 1–10 (with 10 representing the most contributing factor to the severity of oropharyngeal dysphagia). <sup>h</sup> Mean of all participants' ranks (N<sub>Total</sub> = 69).
### 3.3. Statistical Analyses

#### 3.3.1. Exploratory Principal Component Factor Analyses

Three exploratory Principal Component factor analyses were performed for all physical impairments (n = 10), risk factors (n = 23) and prognostic factors (n = 21) that were considered relevant (≥75% agreement) in the process of clinical decision making for the disease trajectory of oropharyngeal dysphagia. The factor analysis including all relevant physical impairments revealed three components explaining 59.1% of the total variance (goodness-of-fit test, *p* < 0.001; Tables 4 and 5); the factor analysis including all relevant risk factors identified six components explaining 74.2% of the total variance (goodness-of-fit test, *p* < 0.001; Tables 6 and 7); and, the factor analysis including all relevant prognostic factors resulted in five components explaining 72.3% of the total variance (goodness-of-fit test, *p* < 0.001; Tables 8 and 9). A factor analysis including all factors combined (i.e., physical impairments, risk factors and prognostic factors) was not performed due to poor sample-to-variable ratio (N:p ratio), referring to the number of participants (n = 69) compared to the total number of included factors (n = 53). Although recommendations differ in the literature, most rules of thumb suggest a minimum ratio of 3:1 [18].

<table><caption>**Table 4.** Exploratory Principal Component factor analyses for Physical Impairments relevant in the process of clinical decision making for the disease trajectory of oropharyngeal dysphagia: Eigenvalues, Percentages of variance and Cumulative percentages for components for 10 physical impairment items.</caption><thead><tr><th>Component</th><th>Eigenvalue</th><th>% of Variance</th><th>Cumulative %</th></tr></thead><tbody><tr><td>1</td><td>2.938</td><td>29.384</td><td>29.384</td></tr><tr><td>2</td><td>1.637</td><td>16.370</td><td>45.754</td></tr><tr><td>3</td><td>1.334</td><td>13.342</td><td>59.096</td></tr></tbody></table>

<table><caption>**Table 5.** Exploratory Principal Component factor analyses for Physical Impairments: Factor loadings and Communalities for Varimax rotated 3-Factor solution for 10 items (n = 69).</caption><thead><tr><th rowspan="2">Physical Impairment<br>Item</th><th colspan="3">Component</th><th rowspan="2">Communalities</th></tr><tr><th>1</th><th>2</th><th>3</th></tr></thead><tbody><tr><td>Sensory deficits in oropharynx</td><td><strong>0.804</strong></td><td>0.115</td><td>0.267</td><td>0.731</td></tr><tr><td>Poor oromotor functioning/skills (e.g., tongue, lip and velum)</td><td><strong>0.750</strong></td><td>-0.283</td><td>0.155</td><td>0.666</td></tr><tr><td>Poor oropharyngeal and laryngeal motor functioning/skills</td><td><strong>0.686</strong></td><td>0.360</td><td>-0.131</td><td>0.618</td></tr><tr><td>Anatomical/Physiological abnormalities</td><td><strong>0.640</strong></td><td>0.399</td><td>-0.158</td><td>0.594</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>0.244</td><td><strong>0.718</strong></td><td>0.168</td><td>0.604</td></tr><tr><td>Tracheostomy and/or ventilation support</td><td>0.185</td><td><strong>0.647</strong></td><td>0.162</td><td>0.479</td></tr><tr><td>Weak or absent cough</td><td>-0.057</td><td><strong>0.528</strong></td><td>-0.006</td><td>0.282</td></tr><tr><td>Choking</td><td>0.069</td><td>-0.235</td><td><strong>0.777</strong></td><td>0.664</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>-0.130</td><td>0.347</td><td><strong>0.724</strong></td><td>0.662</td></tr><tr><td>Aspiration</td><td>0.208</td><td>0.308</td><td><strong>0.687</strong></td><td>0.610</td></tr></tbody></table>

Factor loadings over 0.40 appear in bold. Highest factor loading per item appears against a dark grey background.
### 3.3. Statistical Analyses

#### 3.3.1. Exploratory Principal Component Factor Analyses

Three exploratory Principal Component factor analyses were performed for all physical impairments (n = 10), risk factors (n = 23) and prognostic factors (n = 21) that were considered relevant (≥75% agreement) in the process of clinical decision making for the disease trajectory of oropharyngeal dysphagia. The factor analysis including all relevant physical impairments revealed three components explaining 59.1% of the total variance (goodness-of-fit test, *p* < 0.001; Tables 4 and 5); the factor analysis including all relevant risk factors identified six components explaining 74.2% of the total variance (goodness-of-fit test, *p* < 0.001; Tables 6 and 7); and, the factor analysis including all relevant prognostic factors resulted in five components explaining 72.3% of the total variance (goodness-of-fit test, *p* < 0.001; Tables 8 and 9). A factor analysis including all factors combined (i.e., physical impairments, risk factors and prognostic factors) was not performed due to poor sample-to-variable ratio (N:p ratio), referring to the number of participants (n = 69) compared to the total number of included factors (n = 53). Although recommendations differ in the literature, most rules of thumb suggest a minimum ratio of 3:1 [18].

<table><caption>**Table 4.** Exploratory Principal Component factor analyses for Physical Impairments relevant in the process of clinical decision making for the disease trajectory of oropharyngeal dysphagia: Eigenvalues, Percentages of variance and Cumulative percentages for components for 10 physical impairment items.</caption><thead><tr><th>Component</th><th>Eigenvalue</th><th>% of Variance</th><th>Cumulative %</th></tr></thead><tbody><tr><td>1</td><td>2.938</td><td>29.384</td><td>29.384</td></tr><tr><td>2</td><td>1.637</td><td>16.370</td><td>45.754</td></tr><tr><td>3</td><td>1.334</td><td>13.342</td><td>59.096</td></tr></tbody></table>

<table><caption>**Table 5.** Exploratory Principal Component factor analyses for Physical Impairments: Factor loadings and Communalities for Varimax rotated 3-Factor solution for 10 items (n = 69).</caption><thead><tr><th rowspan="2">Physical Impairment<br>Item</th><th colspan="3">Component</th><th rowspan="2">Communalities</th></tr><tr><th>1</th><th>2</th><th>3</th></tr></thead><tbody><tr><td>Sensory deficits in oropharynx</td><td><strong>0.804</strong></td><td>0.115</td><td>0.267</td><td>0.731</td></tr><tr><td>Poor oromotor functioning/skills (e.g., tongue, lip and velum)</td><td><strong>0.750</strong></td><td>-0.283</td><td>0.155</td><td>0.666</td></tr><tr><td>Poor oropharyngeal and laryngeal motor functioning/skills</td><td><strong>0.686</strong></td><td>0.360</td><td>-0.131</td><td>0.618</td></tr><tr><td>Anatomical/Physiological abnormalities</td><td><strong>0.640</strong></td><td>0.399</td><td>-0.158</td><td>0.594</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>0.244</td><td><strong>0.718</strong></td><td>0.168</td><td>0.604</td></tr><tr><td>Tracheostomy and/or ventilation support</td><td>0.185</td><td><strong>0.647</strong></td><td>0.162</td><td>0.479</td></tr><tr><td>Weak or absent cough</td><td>-0.057</td><td><strong>0.528</strong></td><td>-0.006</td><td>0.282</td></tr><tr><td>Choking</td><td>0.069</td><td>-0.235</td><td><strong>0.777</strong></td><td>0.664</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>-0.130</td><td>0.347</td><td><strong>0.724</strong></td><td>0.662</td></tr><tr><td>Aspiration</td><td>0.208</td><td>0.308</td><td><strong>0.687</strong></td><td>0.610</td></tr></tbody></table>

Factor loadings over 0.40 appear in bold. Highest factor loading per item appears against a dark grey background.
<table><caption>**Table 6.** Exploratory Principal Component factor analyses for Risk Factors relevant in the process of clinical decision making for the disease trajectory of oropharyngeal dysphagia: Eigenvalues, Percentages of variance and Cumulative percentages for components for 23 risk factor items.</caption><thead><tr><th>Component</th><th>Eigenvalue</th><th>% of Variance</th><th>Cumulative %</th></tr></thead><tbody><tr><td>1</td><td>8.879</td><td>38.604</td><td>38.604</td></tr><tr><td>2</td><td>2.273</td><td>9.884</td><td>48.488</td></tr><tr><td>3</td><td>2.054</td><td>8.929</td><td>57.416</td></tr><tr><td>4</td><td>1.486</td><td>6.461</td><td>63.878</td></tr><tr><td>5</td><td>1.300</td><td>5.653</td><td>69.531</td></tr><tr><td>6</td><td>1.081</td><td>4.702</td><td>74.233</td></tr></tbody></table>

<table><caption>**Table 7.** Exploratory Principal Component factor analyses for Risk Factors: Factor loadings and Communalities for Varimax rotated 6-Factor solution for 23 items (n = 69).</caption><thead><tr><th rowspan="2">Item</th><th colspan="6">Component</th><th rowspan="2">Communalities</th></tr><tr><th>1</th><th>2</th><th>3</th><th>4</th><th>5</th><th>6</th></tr></thead><tbody><tr><td>No or limited assessment for oropharyngeal dysphagia</td><td><strong>0.905</strong></td><td>0.082</td><td>0.153</td><td>0.077</td><td>0.177</td><td>0.043</td><td>0.888</td></tr><tr><td>No or limited follow-up of people with oropharyngeal dysphagia</td><td><strong>0.877</strong></td><td>0.065</td><td>0.164</td><td>0.067</td><td>0.222</td><td>0.060</td><td>0.859</td></tr><tr><td>Lack of screening for oropharyngeal dysphagia</td><td><strong>0.819</strong></td><td>0.121</td><td>0.120</td><td>0.209</td><td>-0.209</td><td>0.167</td><td>0.816</td></tr><tr><td>Lack of skilled clinicians to manage and/or care for oropharyngeal dysphagia</td><td><strong>0.698</strong></td><td>0.128</td><td>0.216</td><td>0.086</td><td>0.321</td><td>0.294</td><td>0.747</td></tr><tr><td>Progress and severity of underlying disease</td><td><strong>0.584</strong></td><td>0.168</td><td>0.272</td><td>0.060</td><td><strong>0.492</strong></td><td>0.211</td><td>0.734</td></tr><tr><td>Malnutrition</td><td>0.148</td><td><strong>0.887</strong></td><td>0.159</td><td>0.028</td><td>0.116</td><td>0.049</td><td>0.850</td></tr><tr><td>Dehydration</td><td>0.130</td><td><strong>0.766</strong></td><td>0.157</td><td>0.194</td><td>0.132</td><td>0.113</td><td>0.697</td></tr><tr><td>Insufficient or inadequate oral intake (e.g., caloric intake, consistency, nutritional supplements)</td><td>-0.007</td><td><strong>0.838</strong></td><td>0.131</td><td>-0.012</td><td>0.091</td><td>0.211</td><td>0.772</td></tr><tr><td>Poor oral hygiene</td><td>0.252</td><td><strong>0.497</strong></td><td>-0.175</td><td>0.196</td><td><strong>0.406</strong></td><td>-0.014</td><td>0.544</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills</td><td>0.258</td><td>0.134</td><td><strong>0.764</strong></td><td>0.242</td><td>0.032</td><td>.072</td><td>0.732</td></tr><tr><td>Chronicity of dysphagia</td><td>0.135</td><td>-0.107</td><td><strong>0.682</strong></td><td>0.017</td><td>0.278</td><td>.316</td><td>0.672</td></tr><tr><td>Sensory deficits in oropharynx</td><td>0.326</td><td>0.258</td><td><strong>0.657</strong></td><td>0.238</td><td>-0.114</td><td>0.195</td><td>0.713</td></tr><tr><td>Presence of residue</td><td>0.075</td><td>0.316</td><td><strong>0.514</strong></td><td>0.367</td><td>0.150</td><td>0.038</td><td>0.529</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>0.259</td><td>0.286</td><td><strong>0.467</strong></td><td>0.275</td><td><strong>0.417</strong></td><td>0.187</td><td>0.651</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>0.051</td><td>0.109</td><td>0.260</td><td><strong>0.841</strong></td><td>0.207</td><td>0.047</td><td>0.834</td></tr><tr><td>Choking</td><td>0.250</td><td>0.111</td><td>-0.006</td><td><strong>0.820</strong></td><td>-0.141</td><td>0.229</td><td>0.820</td></tr><tr><td>Aspiration</td><td>0.083</td><td>0.095</td><td>0.372</td><td><strong>0.727</strong></td><td>0.316</td><td>0.089</td><td>0.790</td></tr><tr><td>Tracheostomy and/or ventilation support</td><td>0.287</td><td>0.209</td><td>0.283</td><td>0.108</td><td><strong>0.747</strong></td><td>0.088</td><td>0.784</td></tr><tr><td>Weak or absent cough</td><td>0.071</td><td>-0.092</td><td>0.227</td><td>0.485</td><td><strong>0.509</strong></td><td>0.355</td><td>0.685</td></tr><tr><td>Poor respiratory status, pulmonary infection or pulmonary disease (e.g., COPD)</td><td>0.062</td><td><strong>0.488</strong></td><td>-0.085</td><td>0.112</td><td><strong>0.704</strong></td><td>0.172</td><td>0.788</td></tr><tr><td>Recurrent pulmonary infections</td><td>0.118</td><td>-0.006</td><td>0.081</td><td>0.284</td><td>0.244</td><td><strong>0.749</strong></td><td>0.722</td></tr><tr><td>Impaired cognitive functioning</td><td>0.136</td><td>0.375</td><td>0.384</td><td>0.004</td><td>-0.012</td><td><strong>0.690</strong></td><td>0.783</td></tr><tr><td>Unawareness of the swallowing disorder (i.e., anosognosia)</td><td>0.285</td><td>0.305</td><td>0.154</td><td>0.123</td><td>0.103</td><td><strong>0.664</strong></td><td>0.665</td></tr></tbody></table>

Factor loadings over 0.40 appear in bold. Highest factor loading per item appears against a dark grey background and second highest factor loading against a light grey background (if > 0.40).

<table><caption>**Table 8.** Exploratory Principal Component factor analyses for Prognostic Factors relevant in the process of clinical decision making for the disease trajectory of oropharyngeal dysphagia: Eigenvalues, Percentages of variance and Cumulative percentages for components for 21 prognostic factor items.</caption><thead><tr><th>Component</th><th>Eigenvalue</th><th>% of Variance</th><th>Cumulative %</th></tr></thead><tbody><tr><td>1</td><td>8.423</td><td>40.108</td><td>40.108</td></tr><tr><td>2</td><td>2.345</td><td>11.166</td><td>51.275</td></tr><tr><td>3</td><td>1.980</td><td>9.427</td><td>60.702</td></tr><tr><td>4</td><td>1.337</td><td>6.365</td><td>67.067</td></tr><tr><td>5</td><td>1.094</td><td>5.207</td><td>72.275</td></tr></tbody></table>
<table><caption>**Table 6.** Exploratory Principal Component factor analyses for Risk Factors relevant in the process of clinical decision making for the disease trajectory of oropharyngeal dysphagia: Eigenvalues, Percentages of variance and Cumulative percentages for components for 23 risk factor items.</caption><thead><tr><th>Component</th><th>Eigenvalue</th><th>% of Variance</th><th>Cumulative %</th></tr></thead><tbody><tr><td>1</td><td>8.879</td><td>38.604</td><td>38.604</td></tr><tr><td>2</td><td>2.273</td><td>9.884</td><td>48.488</td></tr><tr><td>3</td><td>2.054</td><td>8.929</td><td>57.416</td></tr><tr><td>4</td><td>1.486</td><td>6.461</td><td>63.878</td></tr><tr><td>5</td><td>1.300</td><td>5.653</td><td>69.531</td></tr><tr><td>6</td><td>1.081</td><td>4.702</td><td>74.233</td></tr></tbody></table>

<table><caption>**Table 7.** Exploratory Principal Component factor analyses for Risk Factors: Factor loadings and Communalities for Varimax rotated 6-Factor solution for 23 items (n = 69).</caption><thead><tr><th rowspan="2">Item</th><th colspan="6">Component</th><th rowspan="2">Communalities</th></tr><tr><th>1</th><th>2</th><th>3</th><th>4</th><th>5</th><th>6</th></tr></thead><tbody><tr><td>No or limited assessment for oropharyngeal dysphagia</td><td><strong>0.905</strong></td><td>0.082</td><td>0.153</td><td>0.077</td><td>0.177</td><td>0.043</td><td>0.888</td></tr><tr><td>No or limited follow-up of people with oropharyngeal dysphagia</td><td><strong>0.877</strong></td><td>0.065</td><td>0.164</td><td>0.067</td><td>0.222</td><td>0.060</td><td>0.859</td></tr><tr><td>Lack of screening for oropharyngeal dysphagia</td><td><strong>0.819</strong></td><td>0.121</td><td>0.120</td><td>0.209</td><td>-0.209</td><td>0.167</td><td>0.816</td></tr><tr><td>Lack of skilled clinicians to manage and/or care for oropharyngeal dysphagia</td><td><strong>0.698</strong></td><td>0.128</td><td>0.216</td><td>0.086</td><td>0.321</td><td>0.294</td><td>0.747</td></tr><tr><td>Progress and severity of underlying disease</td><td><strong>0.584</strong></td><td>0.168</td><td>0.272</td><td>0.060</td><td><strong>0.492</strong></td><td>0.211</td><td>0.734</td></tr><tr><td>Malnutrition</td><td>0.148</td><td><strong>0.887</strong></td><td>0.159</td><td>0.028</td><td>0.116</td><td>0.049</td><td>0.850</td></tr><tr><td>Dehydration</td><td>0.130</td><td><strong>0.766</strong></td><td>0.157</td><td>0.194</td><td>0.132</td><td>0.113</td><td>0.697</td></tr><tr><td>Insufficient or inadequate oral intake (e.g., caloric intake, consistency, nutritional supplements)</td><td>-0.007</td><td><strong>0.838</strong></td><td>0.131</td><td>-0.012</td><td>0.091</td><td>0.211</td><td>0.772</td></tr><tr><td>Poor oral hygiene</td><td>0.252</td><td><strong>0.497</strong></td><td>-0.175</td><td>0.196</td><td><strong>0.406</strong></td><td>-0.014</td><td>0.544</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills</td><td>0.258</td><td>0.134</td><td><strong>0.764</strong></td><td>0.242</td><td>0.032</td><td>.072</td><td>0.732</td></tr><tr><td>Chronicity of dysphagia</td><td>0.135</td><td>-0.107</td><td><strong>0.682</strong></td><td>0.017</td><td>0.278</td><td>.316</td><td>0.672</td></tr><tr><td>Sensory deficits in oropharynx</td><td>0.326</td><td>0.258</td><td><strong>0.657</strong></td><td>0.238</td><td>-0.114</td><td>0.195</td><td>0.713</td></tr><tr><td>Presence of residue</td><td>0.075</td><td>0.316</td><td><strong>0.514</strong></td><td>0.367</td><td>0.150</td><td>0.038</td><td>0.529</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>0.259</td><td>0.286</td><td><strong>0.467</strong></td><td>0.275</td><td><strong>0.417</strong></td><td>0.187</td><td>0.651</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>0.051</td><td>0.109</td><td>0.260</td><td><strong>0.841</strong></td><td>0.207</td><td>0.047</td><td>0.834</td></tr><tr><td>Choking</td><td>0.250</td><td>0.111</td><td>-0.006</td><td><strong>0.820</strong></td><td>-0.141</td><td>0.229</td><td>0.820</td></tr><tr><td>Aspiration</td><td>0.083</td><td>0.095</td><td>0.372</td><td><strong>0.727</strong></td><td>0.316</td><td>0.089</td><td>0.790</td></tr><tr><td>Tracheostomy and/or ventilation support</td><td>0.287</td><td>0.209</td><td>0.283</td><td>0.108</td><td><strong>0.747</strong></td><td>0.088</td><td>0.784</td></tr><tr><td>Weak or absent cough</td><td>0.071</td><td>-0.092</td><td>0.227</td><td>0.485</td><td><strong>0.509</strong></td><td>0.355</td><td>0.685</td></tr><tr><td>Poor respiratory status, pulmonary infection or pulmonary disease (e.g., COPD)</td><td>0.062</td><td><strong>0.488</strong></td><td>-0.085</td><td>0.112</td><td><strong>0.704</strong></td><td>0.172</td><td>0.788</td></tr><tr><td>Recurrent pulmonary infections</td><td>0.118</td><td>-0.006</td><td>0.081</td><td>0.284</td><td>0.244</td><td><strong>0.749</strong></td><td>0.722</td></tr><tr><td>Impaired cognitive functioning</td><td>0.136</td><td>0.375</td><td>0.384</td><td>0.004</td><td>-0.012</td><td><strong>0.690</strong></td><td>0.783</td></tr><tr><td>Unawareness of the swallowing disorder (i.e., anosognosia)</td><td>0.285</td><td>0.305</td><td>0.154</td><td>0.123</td><td>0.103</td><td><strong>0.664</strong></td><td>0.665</td></tr></tbody></table>

Factor loadings over 0.40 appear in bold. Highest factor loading per item appears against a dark grey background and second highest factor loading against a light grey background (if > 0.40).

<table><caption>**Table 8.** Exploratory Principal Component factor analyses for Prognostic Factors relevant in the process of clinical decision making for the disease trajectory of oropharyngeal dysphagia: Eigenvalues, Percentages of variance and Cumulative percentages for components for 21 prognostic factor items.</caption><thead><tr><th>Component</th><th>Eigenvalue</th><th>% of Variance</th><th>Cumulative %</th></tr></thead><tbody><tr><td>1</td><td>8.423</td><td>40.108</td><td>40.108</td></tr><tr><td>2</td><td>2.345</td><td>11.166</td><td>51.275</td></tr><tr><td>3</td><td>1.980</td><td>9.427</td><td>60.702</td></tr><tr><td>4</td><td>1.337</td><td>6.365</td><td>67.067</td></tr><tr><td>5</td><td>1.094</td><td>5.207</td><td>72.275</td></tr></tbody></table>
<table><caption>**Table 9.** Exploratory Principal Component factor analyses for Prognostic Factors: Factor loadings and Communalities for Varimax rotated 5-Factor solution for 21 items (n = 69).</caption><thead><tr><th rowspan="2">Prognostic Factor<br>Item</th><th colspan="5">Component</th><th rowspan="2">Communalities</th></tr><tr><th>1</th><th>2</th><th>3</th><th>4</th><th>5</th></tr></thead><tbody><tr><td>Aspiration</td><td><strong>0.886</strong></td><td>0.144</td><td>0.167</td><td>0.072</td><td>0.006</td><td>0.839</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials<br>from the airways</td><td><strong>0.864</strong></td><td>0.157</td><td>0.082</td><td>0.210</td><td>0.079</td><td>0.828</td></tr><tr><td>Weak or absent cough</td><td><strong>0.826</strong></td><td>-0.002</td><td>-0.012</td><td>0.076</td><td>0.051</td><td>0.691</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor<br>functioning/skills</td><td><strong>0.776</strong></td><td>0.294</td><td>0.262</td><td>0.072</td><td>0.027</td><td>0.763</td></tr><tr><td>Choking</td><td><strong>0.759</strong></td><td>0.131</td><td>0.216</td><td>0.002</td><td>0.081</td><td>0.647</td></tr><tr><td>Sensory deficits in oropharynx</td><td><strong>0.737</strong></td><td>0.308</td><td>0.144</td><td>0.264</td><td>0.036</td><td>0.730</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td><strong>0.553</strong></td><td>0.343</td><td>-0.053</td><td>0.317</td><td>0.373</td><td>0.666</td></tr><tr><td>Impaired cognitive functioning</td><td>0.182</td><td><strong>0.806</strong></td><td>-0.050</td><td>0.067</td><td>0.219</td><td>0.738</td></tr><tr><td>Unawareness of the swallowing disorder (i.e., anosognosia)</td><td>0.095</td><td><strong>0.789</strong></td><td>0.014</td><td>0.272</td><td>0.083</td><td>0.713</td></tr><tr><td>Nonadherence to treatment and medical recommendations</td><td>0.343</td><td><strong>0.778</strong></td><td>0.208</td><td>0.052</td><td>-0.024</td><td>0.770</td></tr><tr><td>Lack of social network/support (i.e., caregiver and family)</td><td>0.120</td><td><strong>0.720</strong></td><td>0.218</td><td>0.087</td><td>0.102</td><td>0.598</td></tr><tr><td>Insufficient or inadequate oral intake (e.g., caloric intake,<br>consistency, nutritional supplements)</td><td>0.257</td><td>0.119</td><td><strong>0.870</strong></td><td>0.040</td><td>0.073</td><td>0.843</td></tr><tr><td>Malnutrition</td><td>0.082</td><td>0.150</td><td><strong>0.836</strong></td><td>0.203</td><td>0.087</td><td>0.777</td></tr><tr><td>Poor respiratory status, pulmonary infection or pulmonary<br>disease (e.g., COPD)</td><td>0.139</td><td>-0.052</td><td><strong>0.552</strong></td><td><strong>0.424</strong></td><td><strong>0.449</strong></td><td>0.708</td></tr><tr><td>Recurrent pulmonary infections</td><td><strong>0.505</strong></td><td>0.094</td><td><strong>0.513</strong></td><td>0.251</td><td>0.147</td><td>0.612</td></tr><tr><td>No or limited assessment for oropharyngeal dysphagia</td><td>0.151</td><td>0.136</td><td>0.264</td><td><strong>0.851</strong></td><td>0.021</td><td>0.835</td></tr><tr><td>No or limited follow-up of people with<br>oropharyngeal dysphagia</td><td>0.228</td><td>0.265</td><td>0.124</td><td><strong>0.776</strong></td><td>0.078</td><td>0.746</td></tr><tr><td>Lack of skilled clinicians to manage and/or care for<br>oropharyngeal dysphagia</td><td>0.180</td><td>0.029</td><td>0.038</td><td>0.374</td><td>-0.594</td><td>0.526</td></tr><tr><td>Respiratory difficulties</td><td>0.239</td><td>0.130</td><td><strong>0.406</strong></td><td>0.320</td><td><strong>0.674</strong></td><td>0.796</td></tr><tr><td>Progress and severity of underlying disease</td><td>0.281</td><td><strong>0.426</strong></td><td>0.083</td><td>0.065</td><td><strong>0.658</strong></td><td>0.704</td></tr><tr><td>Frailty</td><td>0.073</td><td>0.280</td><td>0.297</td><td><strong>0.405</strong></td><td><strong>0.557</strong></td><td>0.646</td></tr></tbody></table>

Factor loadings over 0.40 appear in bold. Highest factor loading per item appear against a dark grey background and second highest factor loading against a light grey background (if > 0.40).

Whereas some factors loaded on more than one component, obvious clustering of related factors was presented in all three exploratory factor analyses (Tables 5, 7 and 9). For example, several factors related to contextual features (e.g., 'No or limited assessment for oropharyngeal dysphagia', 'No or limited follow-up of people with oropharyngeal dysphagia', 'Lack of screening for oropharyngeal dysphagia' and 'Lack of skilled clinicians to manage and/or care for oropharyngeal dysphagia') loaded on the same component (i.e., 1st and 5th component for analyses including risk and prognostic factors, respectively). Also, factors related to impaired airway protection (e.g., 'Choking', 'Aspiration' and 'Incomplete ejection or failure to eject aspirated material from the airways') loaded on the same component (3rd, 4th and 1st component, for analyses including physical impairments, risk factors and prognostic factors, respectively). Similar results were found for oral intake-related factors (i.e., 'Malnutrition' and 'Insufficient or inadequate oral intake [e.g., caloric intake, consistency, nutritional supplements]') loading on the 2nd and 4th component for risk and prognostic factors, respectively. As a third oral intake-related item, 'Dehydration' was not considered a prognostic factor; this item only loaded on the 2nd component for risk factors.

### 3.3.2. Mann-Whitney *U* Tests and Ranking

Mann-Whitney *U* tests were conducted including the top five highest agreement ratings for the importance and relevance of Physical Impairment, Risk Factors and Prognostic Factors (Table 10). None of the thirty tests identified significant group differences between allied health professionals and medical specialists.
<table><caption>**Table 9.** Exploratory Principal Component factor analyses for Prognostic Factors: Factor loadings and Communalities for Varimax rotated 5-Factor solution for 21 items (n = 69).</caption><thead><tr><th rowspan="2">Prognostic Factor<br>Item</th><th colspan="5">Component</th><th rowspan="2">Communalities</th></tr><tr><th>1</th><th>2</th><th>3</th><th>4</th><th>5</th></tr></thead><tbody><tr><td>Aspiration</td><td><strong>0.886</strong></td><td>0.144</td><td>0.167</td><td>0.072</td><td>0.006</td><td>0.839</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials<br>from the airways</td><td><strong>0.864</strong></td><td>0.157</td><td>0.082</td><td>0.210</td><td>0.079</td><td>0.828</td></tr><tr><td>Weak or absent cough</td><td><strong>0.826</strong></td><td>-0.002</td><td>-0.012</td><td>0.076</td><td>0.051</td><td>0.691</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor<br>functioning/skills</td><td><strong>0.776</strong></td><td>0.294</td><td>0.262</td><td>0.072</td><td>0.027</td><td>0.763</td></tr><tr><td>Choking</td><td><strong>0.759</strong></td><td>0.131</td><td>0.216</td><td>0.002</td><td>0.081</td><td>0.647</td></tr><tr><td>Sensory deficits in oropharynx</td><td><strong>0.737</strong></td><td>0.308</td><td>0.144</td><td>0.264</td><td>0.036</td><td>0.730</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td><strong>0.553</strong></td><td>0.343</td><td>-0.053</td><td>0.317</td><td>0.373</td><td>0.666</td></tr><tr><td>Impaired cognitive functioning</td><td>0.182</td><td><strong>0.806</strong></td><td>-0.050</td><td>0.067</td><td>0.219</td><td>0.738</td></tr><tr><td>Unawareness of the swallowing disorder (i.e., anosognosia)</td><td>0.095</td><td><strong>0.789</strong></td><td>0.014</td><td>0.272</td><td>0.083</td><td>0.713</td></tr><tr><td>Nonadherence to treatment and medical recommendations</td><td>0.343</td><td><strong>0.778</strong></td><td>0.208</td><td>0.052</td><td>-0.024</td><td>0.770</td></tr><tr><td>Lack of social network/support (i.e., caregiver and family)</td><td>0.120</td><td><strong>0.720</strong></td><td>0.218</td><td>0.087</td><td>0.102</td><td>0.598</td></tr><tr><td>Insufficient or inadequate oral intake (e.g., caloric intake,<br>consistency, nutritional supplements)</td><td>0.257</td><td>0.119</td><td><strong>0.870</strong></td><td>0.040</td><td>0.073</td><td>0.843</td></tr><tr><td>Malnutrition</td><td>0.082</td><td>0.150</td><td><strong>0.836</strong></td><td>0.203</td><td>0.087</td><td>0.777</td></tr><tr><td>Poor respiratory status, pulmonary infection or pulmonary<br>disease (e.g., COPD)</td><td>0.139</td><td>-0.052</td><td><strong>0.552</strong></td><td><strong>0.424</strong></td><td><strong>0.449</strong></td><td>0.708</td></tr><tr><td>Recurrent pulmonary infections</td><td><strong>0.505</strong></td><td>0.094</td><td><strong>0.513</strong></td><td>0.251</td><td>0.147</td><td>0.612</td></tr><tr><td>No or limited assessment for oropharyngeal dysphagia</td><td>0.151</td><td>0.136</td><td>0.264</td><td><strong>0.851</strong></td><td>0.021</td><td>0.835</td></tr><tr><td>No or limited follow-up of people with<br>oropharyngeal dysphagia</td><td>0.228</td><td>0.265</td><td>0.124</td><td><strong>0.776</strong></td><td>0.078</td><td>0.746</td></tr><tr><td>Lack of skilled clinicians to manage and/or care for<br>oropharyngeal dysphagia</td><td>0.180</td><td>0.029</td><td>0.038</td><td>0.374</td><td>-0.594</td><td>0.526</td></tr><tr><td>Respiratory difficulties</td><td>0.239</td><td>0.130</td><td><strong>0.406</strong></td><td>0.320</td><td><strong>0.674</strong></td><td>0.796</td></tr><tr><td>Progress and severity of underlying disease</td><td>0.281</td><td><strong>0.426</strong></td><td>0.083</td><td>0.065</td><td><strong>0.658</strong></td><td>0.704</td></tr><tr><td>Frailty</td><td>0.073</td><td>0.280</td><td>0.297</td><td><strong>0.405</strong></td><td><strong>0.557</strong></td><td>0.646</td></tr></tbody></table>

Factor loadings over 0.40 appear in bold. Highest factor loading per item appear against a dark grey background and second highest factor loading against a light grey background (if > 0.40).

Whereas some factors loaded on more than one component, obvious clustering of related factors was presented in all three exploratory factor analyses (Tables 5, 7 and 9). For example, several factors related to contextual features (e.g., 'No or limited assessment for oropharyngeal dysphagia', 'No or limited follow-up of people with oropharyngeal dysphagia', 'Lack of screening for oropharyngeal dysphagia' and 'Lack of skilled clinicians to manage and/or care for oropharyngeal dysphagia') loaded on the same component (i.e., 1st and 5th component for analyses including risk and prognostic factors, respectively). Also, factors related to impaired airway protection (e.g., 'Choking', 'Aspiration' and 'Incomplete ejection or failure to eject aspirated material from the airways') loaded on the same component (3rd, 4th and 1st component, for analyses including physical impairments, risk factors and prognostic factors, respectively). Similar results were found for oral intake-related factors (i.e., 'Malnutrition' and 'Insufficient or inadequate oral intake [e.g., caloric intake, consistency, nutritional supplements]') loading on the 2nd and 4th component for risk and prognostic factors, respectively. As a third oral intake-related item, 'Dehydration' was not considered a prognostic factor; this item only loaded on the 2nd component for risk factors.

### 3.3.2. Mann-Whitney *U* Tests and Ranking

Mann-Whitney *U* tests were conducted including the top five highest agreement ratings for the importance and relevance of Physical Impairment, Risk Factors and Prognostic Factors (Table 10). None of the thirty tests identified significant group differences between allied health professionals and medical specialists.
<table><caption>**Table 10.** Group differences between allied health professionals and medical specialists for item agreement ratings (top five): Mann–Whitney *U* test.</caption><thead><tr><th rowspan="2">Factor</th><th rowspan="2">Item (Top Five)</th><th rowspan="2">% Agreement (All Participant)</th><th colspan="2">AH</th><th rowspan="2">U</th><th rowspan="2">p-Value (Two-Tailed)</th></tr><tr><th>MN Rank (n)</th><th>MS Rank (n)</th></tr></thead><tbody><tr><td rowspan="10">Physical Impairment</td><td>Poor oromotor functioning/skills (e.g., tongue, lip and velum)</td><td>97.3</td><td>36.78 (38)</td><td>39.26 (37)</td><td>749.5</td><td>0.570</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills</td><td>96.8</td><td>30.68 (36)</td><td>32.36 (26)</td><td>497.5</td><td>0.621</td></tr><tr><td>Sensory deficits in oropharynx</td><td>96.0</td><td>38.95 (38)</td><td>37.03 (37)</td><td>667.0</td><td>0.660</td></tr><tr><td>Weak or absent cough</td><td>94.7</td><td>35.32 (38)</td><td>40.76 (37)</td><td>805.0</td><td>0.174</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>93.3</td><td>36.61 (38)</td><td>39.43 (37)</td><td>756.0</td><td>0.487</td></tr><tr><td>Weak or absent cough</td><td>100</td><td>37.57 (38)</td><td>38.45 (37)</td><td>719.5</td><td>0.756</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>98.6</td><td>37.21 (38)</td><td>38.81 (37)</td><td>733.0</td><td>0.638</td></tr><tr><td>Sensory deficits in oropharynx</td><td>97.3</td><td>40.09 (38)</td><td>35.85 (37)</td><td>623.5</td><td>0.332</td></tr><tr><td>Lack of skilled clinicians to manage and/or care for oropharyngeal dysphagia</td><td>96.8</td><td>33.24 (36)</td><td>29.10 (26)</td><td>405.5</td><td>0.310</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>96.7</td><td>30.11 (36)</td><td>33.42 (26)</td><td>518.0</td><td>0.382</td></tr><tr><td rowspan="5">Importance <sup>a</sup></td><td>Progress and severity of underlying disease</td><td>95.2</td><td>32.89 (36)</td><td>29.58 (26)</td><td>418.0</td><td>0.368</td></tr><tr><td>No or limited assessment for oropharyngeal dysphagia</td><td>94.6</td><td>38.71 (38)</td><td>37.27 (37)</td><td>676.0</td><td>0.747</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills</td><td>93.6</td><td>31.67 (36)</td><td>31.27 (26)</td><td>462.0</td><td>0.921</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>93.5</td><td>30.63 (36)</td><td>32.71 (26)</td><td>499.5</td><td>0.610</td></tr><tr><td>Sarcopenia</td><td>93.3</td><td>39.89 (38)</td><td>36.05 (37)</td><td>631.0</td><td>0.392</td></tr><tr><td rowspan="10">Prognostic Factor</td><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>98.6</td><td>34.45 (38)</td><td>35.45 (31)</td><td>572.0</td><td>0.784</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills</td><td>94.2</td><td>35.06 (38)</td><td>34.95 (31)</td><td>591.0</td><td>0.978</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>92.8</td><td>32.19 (38)</td><td>37.29 (31)</td><td>502.0</td><td>0.240</td></tr><tr><td>Aspiration</td><td>91.3</td><td>36.24 (38)</td><td>33.99 (31)</td><td>627.5</td><td>0.576</td></tr><tr><td>Poor oromotor functioning/skills (e.g., tongue, lip and velum)</td><td>86.9</td><td>32.71 (38)</td><td>36.87 (31)</td><td>518.0</td><td>0.345</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>92.8</td><td>34.97 (38)</td><td>35.03 (31)</td><td>590.0</td><td>0.988</td></tr><tr><td>Aspiration</td><td>92.8</td><td>35.94 (38)</td><td>34.24 (31)</td><td>618.0</td><td>0.679</td></tr><tr><td>Weak or absent cough</td><td>91.3</td><td>31.66 (38)</td><td>37.72 (31)</td><td>485.5</td><td>0.145</td></tr><tr><td>Recurrent pulmonary infections</td><td>88.4</td><td>32.58 (38)</td><td>36.97 (31)</td><td>514.0</td><td>0.315</td></tr><tr><td>Choking</td><td>88.4</td><td>35.48 (38)</td><td>34.61 (31)</td><td>604.0</td><td>0.841</td></tr></tbody></table>
<table><caption>**Table 10.** Group differences between allied health professionals and medical specialists for item agreement ratings (top five): Mann–Whitney *U* test.</caption><thead><tr><th rowspan="2">Factor</th><th rowspan="2">Item (Top Five)</th><th rowspan="2">% Agreement (All Participant)</th><th colspan="2">MS</th><th rowspan="2">U</th><th rowspan="2">p-Value (Two-Tailed)</th></tr><tr><th>MN Rank (n)</th><th>MN Rank (n)</th></tr></thead><tbody><tr><td rowspan="10">Physical Impairment</td><td>Poor oromotor functioning/skills (e.g., tongue, lip and velum)</td><td>97.3</td><td>36.78 (38)</td><td>39.26 (37)</td><td>749.5</td><td>0.570</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills</td><td>96.8</td><td>30.68 (36)</td><td>32.36 (26)</td><td>497.5</td><td>0.621</td></tr><tr><td>Sensory deficits in oropharynx</td><td>96.0</td><td>38.95 (38)</td><td>37.03 (37)</td><td>667.0</td><td>0.660</td></tr><tr><td>Weak or absent cough</td><td>94.7</td><td>35.32 (38)</td><td>40.76 (37)</td><td>805.0</td><td>0.174</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>93.3</td><td>36.61 (38)</td><td>39.43 (37)</td><td>756.0</td><td>0.487</td></tr><tr><td>Weak or absent cough</td><td>100</td><td>37.57 (38)</td><td>38.45 (37)</td><td>719.5</td><td>0.756</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>98.6</td><td>37.21 (38)</td><td>38.81 (37)</td><td>733.0</td><td>0.638</td></tr><tr><td>Sensory deficits in oropharynx</td><td>97.3</td><td>40.09 (38)</td><td>35.85 (37)</td><td>623.5</td><td>0.332</td></tr><tr><td>Lack of skilled clinicians to manage and/or care for oropharyngeal dysphagia</td><td>96.8</td><td>33.24 (36)</td><td>29.10 (26)</td><td>405.5</td><td>0.310</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>96.7</td><td>30.11 (36)</td><td>33.42 (26)</td><td>518.0</td><td>0.382</td></tr><tr><td rowspan="5">Importance <sup>a</sup></td><td>Progress and severity of underlying disease</td><td>95.2</td><td>32.89 (36)</td><td>29.58 (26)</td><td>418.0</td><td>0.368</td></tr><tr><td>No or limited assessment for oropharyngeal dysphagia</td><td>94.6</td><td>38.71 (38)</td><td>37.27 (37)</td><td>676.0</td><td>0.747</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills</td><td>93.6</td><td>31.67 (36)</td><td>31.27 (26)</td><td>462.0</td><td>0.921</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>93.5</td><td>30.63 (36)</td><td>32.71 (26)</td><td>499.5</td><td>0.610</td></tr><tr><td>Sarcopenia</td><td>93.3</td><td>39.89 (38)</td><td>36.05 (37)</td><td>631.0</td><td>0.392</td></tr><tr><td rowspan="10">Prognostic Factor</td><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>98.6</td><td>34.45 (38)</td><td>35.45 (31)</td><td>572.0</td><td>0.784</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills</td><td>94.2</td><td>35.06 (38)</td><td>34.95 (31)</td><td>591.0</td><td>0.978</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>92.8</td><td>32.19 (38)</td><td>37.29 (31)</td><td>502.0</td><td>0.240</td></tr><tr><td>Aspiration</td><td>91.3</td><td>36.24 (38)</td><td>33.99 (31)</td><td>627.5</td><td>0.576</td></tr><tr><td>Poor oromotor functioning/skills (e.g., tongue, lip and velum)</td><td>86.9</td><td>32.71 (38)</td><td>36.87 (31)</td><td>518.0</td><td>0.345</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>92.8</td><td>34.97 (38)</td><td>35.03 (31)</td><td>590.0</td><td>0.988</td></tr><tr><td>Aspiration</td><td>92.8</td><td>35.94 (38)</td><td>34.24 (31)</td><td>618.0</td><td>0.679</td></tr><tr><td>Weak or absent cough</td><td>91.3</td><td>31.66 (38)</td><td>37.72 (31)</td><td>485.5</td><td>0.145</td></tr><tr><td>Recurrent pulmonary infections</td><td>88.4</td><td>32.58 (38)</td><td>36.97 (31)</td><td>514.0</td><td>0.315</td></tr><tr><td>Choking</td><td>88.4</td><td>35.48 (38)</td><td>34.61 (31)</td><td>604.0</td><td>0.841</td></tr></tbody></table>
<table><caption>Table 10. *Cont.*</caption><thead><tr><th rowspan="2">Factor</th><th rowspan="2">Item (Top Five)</th><th rowspan="2">% Agreement<br>(All Participant)</th><th colspan="2">AH</th><th rowspan="2">U</th><th rowspan="2">p-Value<br>(Two-Tailed)</th></tr><tr><th>MN Rank (n)</th><th>MS<br>MN Rank (n)</th></tr></thead><tbody><tr><td rowspan="5">Prognostic Factor</td><td>Progress and severity of underlying disease</td><td>95.6</td><td>33.48 (38)</td><td>36.24 (31)</td><td>542.0</td><td>0.519</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>89.9</td><td>35.02 (38)</td><td>34.99 (31)</td><td>589.5</td><td>0.995</td></tr><tr><td>Weak or absent cough</td><td>87.0</td><td>37.26 (38)</td><td>33.16 (31)</td><td>659.0</td><td>0.353</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>85.5</td><td>36.94 (38)</td><td>33.42 (31)</td><td>649.0</td><td>0.424</td></tr><tr><td>Aspiration</td><td>85.5</td><td>38.21 (38)</td><td>32.38 (31)</td><td>688.5</td><td>0.190</td></tr></tbody></table>

<footnote>a Importance of factors as physiological impairment, risk factor, and/or prognostic factor. b Relevance of factors (i.e., physiological impairment, risk factor, and/or prognostic factor) in clinical decision making in the disease trajectory of oropharyngeal dysphagia.</footnote>
<table><caption>Table 10. *Cont.*</caption><thead><tr><th rowspan="2">Factor</th><th rowspan="2">Item (Top Five)</th><th rowspan="2">% Agreement (All Participant)</th><th colspan="2">MS</th><th rowspan="2">U</th><th rowspan="2">p-Value (Two-Tailed)</th></tr><tr><th>AH</th><th>MS</th></tr><tr><th></th><th></th><th></th><th>MN Rank (n)</th><th>MN Rank (n)</th><th></th><th></th></tr></thead><tbody><tr><td rowspan="5">Prognostic Factor</td><td>Progress and severity of underlying disease</td><td>95.6</td><td>33.48 (38)</td><td>36.24 (31)</td><td>542.0</td><td>0.519</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>89.9</td><td>35.02 (38)</td><td>34.99 (31)</td><td>589.5</td><td>0.995</td></tr><tr><td>Weak or absent cough</td><td>87.0</td><td>37.26 (38)</td><td>33.16 (31)</td><td>659.0</td><td>0.353</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>85.5</td><td>36.94 (38)</td><td>33.42 (31)</td><td>649.0</td><td>0.424</td></tr><tr><td>Aspiration</td><td>85.5</td><td>38.21 (38)</td><td>32.38 (31)</td><td>688.5</td><td>0.190</td></tr></tbody></table>

<footnote>a Importance of factors as physiological impairment, risk factor, and/or prognostic factor. b Relevance of factors (i.e., physiological impairment, risk factor, and/or prognostic factor) in clinical decision making in the disease trajectory of oropharyngeal dysphagia.</footnote>
Similarly, group differences between professions were evaluated between the top ten rankings for factors that most contribute to the severity of oropharyngeal dysphagia (Table 11). Both allied health professionals and medical specialists included the following six factors in their top ten rankings (high to low-rank order): ‘Aspiration’, ‘Incomplete ejection or failure to eject aspirated materials from the airways’, ‘Weak or absent cough’, ‘Choking’, ‘Sensory deficits in oropharynx’ and ‘Poor oromotor functioning/skills (e.g., tongue, lip and velum)’. The remaining four top ten listed factors differed between professional groups but were still listed within the top 15 (medical specialists) or top 14 (allied health professionals) of the highest group rankings.

<table><caption>**Table 11. Ranking of factors that most contribute to the severity of oropharyngeal dysphagia: differences in ranking between allied health professionals and medical specialists.**</caption><thead><tr><th rowspan="2">Item</th><th colspan="3">All Participants (n = 69)</th><th colspan="3">Allied Health (n = 38)</th><th colspan="3">Medical Specialists (n = 31)</th></tr><tr><th>Final Rank</th><th>Sum Rank</th><th>MN Rank (Sum Rank/n)</th><th>Final Rank</th><th>Sum Rank</th><th>MN Rank (Sum Rank/n)</th><th>Final Rank</th><th>Sum Rank</th><th>MN Rank (Sum Rank/n)</th></tr></thead><tbody><tr><td>Aspiration</td><td>1</td><td>390</td><td>5.65</td><td>1</td><td>211</td><td>5.55</td><td>1</td><td>179</td><td>5.77</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>2</td><td>357</td><td>5.17</td><td>2</td><td>185</td><td>4.87</td><td>2</td><td>172</td><td>5.55</td></tr><tr><td>Weak or absent cough</td><td>3</td><td>344</td><td>4.98</td><td>3</td><td>180</td><td>4.74</td><td>3</td><td>164</td><td>5.29</td></tr><tr><td>Choking</td><td>4</td><td>204</td><td>2.96</td><td>6</td><td>95</td><td>2.50</td><td>4</td><td>109</td><td>3.52</td></tr><tr><td>Sensory deficits in oropharynx</td><td>5</td><td>187</td><td>2.71</td><td>4</td><td>132</td><td>3.47</td><td>10</td><td>55</td><td>1.77</td></tr><tr><td>Poor oromotor functioning/skills (e.g., tongue, lip and velum)</td><td>6</td><td>182</td><td>2.64</td><td>7</td><td>93</td><td>2.45</td><td>6</td><td>89</td><td>2.87</td></tr><tr><td>Recurrent pulmonary infections</td><td>7</td><td>151</td><td>2.19</td><td>14</td><td>47</td><td>1.24</td><td>5</td><td>104</td><td>3.36</td></tr><tr><td>Poor respiratory status, pulmonary infection or pulmonary disease (e.g., COPD)</td><td>8</td><td>136</td><td>1.97</td><td>5</td><td>102</td><td>2.68</td><td>15</td><td>34</td><td>1.10</td></tr><tr><td>Progress and severity of underlying disease</td><td>9</td><td>123</td><td>1.78</td><td>8</td><td>81</td><td>2.13</td><td>12</td><td>42</td><td>1.36</td></tr><tr><td>Presence of residue</td><td>10</td><td>116</td><td>1.68</td><td>11</td><td>57</td><td>1.50</td><td>9</td><td>59</td><td>1.90</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills</td><td>11</td><td>113</td><td>1.64</td><td>10</td><td>64</td><td>1.68</td><td>11</td><td>49</td><td>1.58</td></tr><tr><td>Insufficient or inadequate oral intake (e.g., caloric intake, consistency, nutritional supplements)</td><td>12</td><td>107</td><td>1.55</td><td>18</td><td>41</td><td>1.08</td><td>7</td><td>66</td><td>2.13</td></tr><tr><td>Malnutrition</td><td>13</td><td>106</td><td>1.54</td><td>16</td><td>46</td><td>1.21</td><td>8</td><td>60</td><td>1.94</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>14</td><td>105</td><td>1.52</td><td>9</td><td>67</td><td>1.76</td><td>13</td><td>38</td><td>1.23</td></tr><tr><td>Frailty</td><td>15</td><td>81</td><td>1.17</td><td>15</td><td>46</td><td>1.21</td><td>14</td><td>35</td><td>1.13</td></tr></tbody></table>

Note. Data against a grey background refer to items in the group's top ten (i.e., all participants, allied health professionals and/or medical specialists).

# 4. Discussion

## 4.1. *Decision Making in Patients' Disease Trajectory*

Participant numbers ranged from 62 to 75 across three Delphi rounds. According to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) group, a minimum of 50 experts support very good methodological quality for quantitative studies such as this Delphi study [19]. Furthermore, the vast majority of participants (over 60%) had completed a higher degree by research or Master's degree (around 30 to 35%), and most participants reported many years of experience working with adults with dysphagia, of whom over 40% reported more than 20 years of experience, indicating highly qualified and experienced Delphi participants.

After three Delphi rounds, a total of 29 factors were considered relevant in the clinical decision-making process (Table 3): 10 physiological impairments, 23 risk factors and 21 prognostic factors. Seven of these 29 factors were identified as relevant as a physiological impairment, risk factor and prognostic factor: ‘Aspiration’, ‘Incomplete ejection or failure
Similarly, group differences between professions were evaluated between the top ten rankings for factors that most contribute to the severity of oropharyngeal dysphagia (Table 11). Both allied health professionals and medical specialists included the following six factors in their top ten rankings (high to low-rank order): ‘Aspiration’, ‘Incomplete ejection or failure to eject aspirated materials from the airways’, ‘Weak or absent cough’, ‘Choking’, ‘Sensory deficits in oropharynx’ and ‘Poor oromotor functioning/skills (e.g., tongue, lip and velum)’. The remaining four top ten listed factors differed between professional groups but were still listed within the top 15 (medical specialists) or top 14 (allied health professionals) of the highest group rankings.

<table><caption>**Table 11. Ranking of factors that most contribute to the severity of oropharyngeal dysphagia: differences in ranking between allied health professionals and medical specialists.**</caption><thead><tr><th rowspan="2">Item</th><th colspan="3">All Participants (n = 69)</th><th colspan="3">Allied Health (n = 38)</th><th colspan="3">Medical Specialists (n = 31)</th></tr><tr><th>Final Rank</th><th>Sum Rank</th><th>MN Rank (Sum Rank/n)</th><th>Final Rank</th><th>Sum Rank</th><th>MN Rank (Sum Rank/n)</th><th>Final Rank</th><th>Sum Rank</th><th>MN Rank (Sum Rank/n)</th></tr></thead><tbody><tr><td>Aspiration</td><td>1</td><td>390</td><td>5.65</td><td>1</td><td>211</td><td>5.55</td><td>1</td><td>179</td><td>5.77</td></tr><tr><td>Incomplete ejection or failure to eject aspirated materials from the airways</td><td>2</td><td>357</td><td>5.17</td><td>2</td><td>185</td><td>4.87</td><td>2</td><td>172</td><td>5.55</td></tr><tr><td>Weak or absent cough</td><td>3</td><td>344</td><td>4.98</td><td>3</td><td>180</td><td>4.74</td><td>3</td><td>164</td><td>5.29</td></tr><tr><td>Choking</td><td>4</td><td>204</td><td>2.96</td><td>6</td><td>95</td><td>2.50</td><td>4</td><td>109</td><td>3.52</td></tr><tr><td>Sensory deficits in oropharynx</td><td>5</td><td>187</td><td>2.71</td><td>4</td><td>132</td><td>3.47</td><td>10</td><td>55</td><td>1.77</td></tr><tr><td>Poor oromotor functioning/skills (e.g., tongue, lip and velum)</td><td>6</td><td>182</td><td>2.64</td><td>7</td><td>93</td><td>2.45</td><td>6</td><td>89</td><td>2.87</td></tr><tr><td>Recurrent pulmonary infections</td><td>7</td><td>151</td><td>2.19</td><td>14</td><td>47</td><td>1.24</td><td>5</td><td>104</td><td>3.36</td></tr><tr><td>Poor respiratory status, pulmonary infection or pulmonary disease (e.g., COPD)</td><td>8</td><td>136</td><td>1.97</td><td>5</td><td>102</td><td>2.68</td><td>15</td><td>34</td><td>1.10</td></tr><tr><td>Progress and severity of underlying disease</td><td>9</td><td>123</td><td>1.78</td><td>8</td><td>81</td><td>2.13</td><td>12</td><td>42</td><td>1.36</td></tr><tr><td>Presence of residue</td><td>10</td><td>116</td><td>1.68</td><td>11</td><td>57</td><td>1.50</td><td>9</td><td>59</td><td>1.90</td></tr><tr><td>Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills</td><td>11</td><td>113</td><td>1.64</td><td>10</td><td>64</td><td>1.68</td><td>11</td><td>49</td><td>1.58</td></tr><tr><td>Insufficient or inadequate oral intake (e.g., caloric intake, consistency, nutritional supplements)</td><td>12</td><td>107</td><td>1.55</td><td>18</td><td>41</td><td>1.08</td><td>7</td><td>66</td><td>2.13</td></tr><tr><td>Malnutrition</td><td>13</td><td>106</td><td>1.54</td><td>16</td><td>46</td><td>1.21</td><td>8</td><td>60</td><td>1.94</td></tr><tr><td>Post-coma status and/or level of consciousness or alertness</td><td>14</td><td>105</td><td>1.52</td><td>9</td><td>67</td><td>1.76</td><td>13</td><td>38</td><td>1.23</td></tr><tr><td>Frailty</td><td>15</td><td>81</td><td>1.17</td><td>15</td><td>46</td><td>1.21</td><td>14</td><td>35</td><td>1.13</td></tr></tbody></table>

Note. Data against a grey background refer to items in the group's top ten (i.e., all participants, allied health professionals and/or medical specialists).

# 4. Discussion

## 4.1. *Decision Making in Patients' Disease Trajectory*

Participant numbers ranged from 62 to 75 across three Delphi rounds. According to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) group, a minimum of 50 experts support very good methodological quality for quantitative studies such as this Delphi study [19]. Furthermore, the vast majority of participants (over 60%) had completed a higher degree by research or Master's degree (around 30 to 35%), and most participants reported many years of experience working with adults with dysphagia, of whom over 40% reported more than 20 years of experience, indicating highly qualified and experienced Delphi participants.

After three Delphi rounds, a total of 29 factors were considered relevant in the clinical decision-making process (Table 3): 10 physiological impairments, 23 risk factors and 21 prognostic factors. Seven of these 29 factors were identified as relevant as a physiological impairment, risk factor and prognostic factor: ‘Aspiration’, ‘Incomplete ejection or failure
to eject aspirated materials from the airways', 'Weak or absent cough', 'Choking', 'Sensory deficits in oropharynx', 'Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills' and 'Post-coma status and/or level of consciousness or alertness'. Ten factors were identified as both risk and prognostic factors, and one factor was identified as both a physical impairment and a risk factor. The remaining 11 factors were either considered a physical impairment (n = 2), a risk factor (n = 5) or a prognostic factor (n = 4).

When comparing the list of relevant factors with the four-topic approach by Jonsen et al. [11], a limited number of items referred to contextual features (e.g., 'Caregiver dependence when eating [no or limited self-feeding skills]', 'Lack of social network/support [i.e., caregiver and family]' and 'Lack of skilled clinicians to manage and/or care for oropharyngeal dysphagia'), very few items referred to patient autonomy and preferences in treatment (e.g., 'Nonadherence to treatment and medical recommendations' and 'Impaired cognitive functioning'), and no items referred to patient quality of life before and after treatment. As most factors refer to patient medical status, it could be argued that the extent to which a factor impacts clinical decision making in relation to disease trajectory (i.e., relevance ratings) or to oropharyngeal dysphagia (i.e., severity rankings), is predominantly determined by medical indications (diagnostic and therapeutic interventions, i.e., Jonsen's fourth topic).

The concept of factor relevance, however, differed from the ranked contribution to the severity of oropharyngeal dysphagia. In relation to factors considered most contributory to dysphagia severity, some were considered highly relevant (≥80% agreement), but received relatively low severity rankings: e.g., 'No or limited follow-up of people with oropharyngeal dysphagia' (ranked 43), 'Lack of social network/support (i.e., caregiver and family)' (ranked 36) and 'Lack of skilled clinicians to manage and/or care for oropharyngeal dysphagia' (ranked 24) and 'Unawareness of the swallowing disorder (i.e., anosognosia)' (ranked 22).

When conducting exploratory Principal Component factor analyses for all physical impairments, risk factors and prognostic factors that were considered relevant, variables were grouped together, likely representing the same underlying construct or domain. Similar tendencies may be apparent from the ranking of variables contributing to the severity of dysphagia. For example, the top four ranked variables all referred to impaired airway protection (i.e., 'Aspiration', 'Incomplete ejection or failure to eject aspirated materials from the airways', 'Weak or absent cough' and 'Choking'). Also, 'Recurrent pulmonary infections' (ranked 7) and 'Poor respiratory status, pulmonary infection or pulmonary disease (e.g., COPD)' (ranked 8) are related factors. Therefore, the ranked order of how factors contribute to dysphagia severity may need to be interpreted as representing different domains, instead of individual factors. Clinicians potentially compare and prioritise selected domains that represent a group of correlated individual factors when making decisions relating to patients' disease trajectories. Similarly, differences were observed when comparing domain rankings between medical specialists and allied health professionals, for example, physicians generally ranked oral intake-related problems (i.e., 'Insufficient or inadequate oral intake [e.g., caloric intake, consistency, nutritional supplements]' and 'Malnutrition') significantly higher than allied health professionals.

## 4.2. *Strengths and Limitations*

The current Delphi study benefitted considerably from the incorporation of multiple opportunities for highly qualified and experienced participant feedback and discussion. Participants were encouraged to provide feedback throughout each survey using open text boxes for additional comments and to provide rationales for their ratings, or for feedback about the study in general. The authors used participant discussion and arguments to inform, for example, decisions about the inclusion of additional factors in progressive Delphi rounds. Further, participants were informed following each Delphi round about previous survey results, including decisions on excluded factors based on participant agreement ratings. However, while participants were considerably diverse in relation to geographi-
to eject aspirated materials from the airways', 'Weak or absent cough', 'Choking', 'Sensory deficits in oropharynx', 'Poor oropharyngeal, hypopharyngeal and laryngeal motor functioning/skills' and 'Post-coma status and/or level of consciousness or alertness'. Ten factors were identified as both risk and prognostic factors, and one factor was identified as both a physical impairment and a risk factor. The remaining 11 factors were either considered a physical impairment (n = 2), a risk factor (n = 5) or a prognostic factor (n = 4).

When comparing the list of relevant factors with the four-topic approach by Jonsen et al. [11], a limited number of items referred to contextual features (e.g., 'Caregiver dependence when eating [no or limited self-feeding skills]', 'Lack of social network/support [i.e., caregiver and family]' and 'Lack of skilled clinicians to manage and/or care for oropharyngeal dysphagia'), very few items referred to patient autonomy and preferences in treatment (e.g., 'Nonadherence to treatment and medical recommendations' and 'Impaired cognitive functioning'), and no items referred to patient quality of life before and after treatment. As most factors refer to patient medical status, it could be argued that the extent to which a factor impacts clinical decision making in relation to disease trajectory (i.e., relevance ratings) or to oropharyngeal dysphagia (i.e., severity rankings), is predominantly determined by medical indications (diagnostic and therapeutic interventions, i.e., Jonsen's fourth topic).

The concept of factor relevance, however, differed from the ranked contribution to the severity of oropharyngeal dysphagia. In relation to factors considered most contributory to dysphagia severity, some were considered highly relevant (≥80% agreement), but received relatively low severity rankings: e.g., 'No or limited follow-up of people with oropharyngeal dysphagia' (ranked 43), 'Lack of social network/support (i.e., caregiver and family)' (ranked 36) and 'Lack of skilled clinicians to manage and/or care for oropharyngeal dysphagia' (ranked 24) and 'Unawareness of the swallowing disorder (i.e., anosognosia)' (ranked 22).

When conducting exploratory Principal Component factor analyses for all physical impairments, risk factors and prognostic factors that were considered relevant, variables were grouped together, likely representing the same underlying construct or domain. Similar tendencies may be apparent from the ranking of variables contributing to the severity of dysphagia. For example, the top four ranked variables all referred to impaired airway protection (i.e., 'Aspiration', 'Incomplete ejection or failure to eject aspirated materials from the airways', 'Weak or absent cough' and 'Choking'). Also, 'Recurrent pulmonary infections' (ranked 7) and 'Poor respiratory status, pulmonary infection or pulmonary disease (e.g., COPD)' (ranked 8) are related factors. Therefore, the ranked order of how factors contribute to dysphagia severity may need to be interpreted as representing different domains, instead of individual factors. Clinicians potentially compare and prioritise selected domains that represent a group of correlated individual factors when making decisions relating to patients' disease trajectories. Similarly, differences were observed when comparing domain rankings between medical specialists and allied health professionals, for example, physicians generally ranked oral intake-related problems (i.e., 'Insufficient or inadequate oral intake [e.g., caloric intake, consistency, nutritional supplements]' and 'Malnutrition') significantly higher than allied health professionals.

## 4.2. *Strengths and Limitations*

The current Delphi study benefitted considerably from the incorporation of multiple opportunities for highly qualified and experienced participant feedback and discussion. Participants were encouraged to provide feedback throughout each survey using open text boxes for additional comments and to provide rationales for their ratings, or for feedback about the study in general. The authors used participant discussion and arguments to inform, for example, decisions about the inclusion of additional factors in progressive Delphi rounds. Further, participants were informed following each Delphi round about previous survey results, including decisions on excluded factors based on participant agreement ratings. However, while participants were considerably diverse in relation to geographi-
cal contexts (from 31 countries and five continents) and professional backgrounds, study outcomes remain highly dependent on the subjective perspectives of included participants.

Further, Exploratory Principal Component factor analyses were limited by poor sample-to-variable ratios. Therefore, analyses were conducted for each type of factor separately (i.e., physiological impairments, risk factors, and prognostic factors), but not for all factors combined. Combining the total number of relevant factors (n = 53) as determined by the current participants (n = 69) would have required higher recruitment numbers of at least triple the number of factors (n ≥ 159) [18].

## 5. Conclusions

This Delphi study reports on the first attempt to develop an international consensus on a clinical decision tree for the disease trajectory of oropharyngeal dysphagia in adults taking into account physiological impairments of swallowing, risk factors for the development of complications from oropharyngeal dysphagia, and prognostic factors for treatment outcome. A total of 10 physiological impairments, 23 risk factors and 21 prognostic factors were identified as relevant factors in the clinical decision-making process. Factors considered to contribute most to the severity of oropharyngeal dysphagia were ‘Aspiration’, ‘Incomplete ejection or failure to eject aspirated materials from the airways’, ‘Weak or absent cough’, ‘Choking’ and ‘Sensory deficits in oropharynx’. Future research is required to develop the current findings and confirm the domains based on relevant factors for clinical decision making, and those that contribute to the severity of oropharyngeal dysphagia, linking the current theoretical framework to clinical practice.

**Supplementary Materials:** The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/jcm12206572/s1, Supplementary File S1: Structure and content of Delphi rounds.

**Author Contributions:** Conceptualization: V.W. and R.S. Formal Analysis: R.S. and V.W. Project Administration: R.S., V.W., M.B. and G.S. Validation: R.S. and V.W. Writing—Review and Editing: R.S., V.W., M.B., E.C., C.D., S.M., G.S. and E.V. All authors have read and agreed to the published version of the manuscript.

**Funding:** This project was supported by the French National Research Agency (ANR-21-CE19-0057-01).

**Institutional Review Board Statement:** The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of Sud-Ouest et Outre Mer II (Comité de Protection des Personnes Sud-Ouest et Outre Mer II, France: 23.00117.000173; 16 March 2023).

**Informed Consent Statement:** Informed consent was obtained from all participants involved in the study.

**Data Availability Statement:** Data is available on request due to ethical restrictions.

**Conflicts of Interest:** The authors declare no conflict of interest.

## References

1. Speyer, R.; Cordier, R.; Denman, D.; Windsor, C.; Krisciunas, G.P.; Smithard, D.; Heijnen, B.J. Development of Two Patient Self-Reported Measures on Functional Health Status (FOD) and Health-Related Quality of Life (QOD) in Adults with Oropharyngeal Dysphagia Using the Delphi Technique. *J. Clin. Med.* **2022**, *11*, 5920. [CrossRef] [PubMed]

2. Kertscher, B.; Speyer, R.; Fong, E.; Georgiou, A.M.; Smith, M. Prevalence of oropharyngeal dysphagia in the Netherlands: A telephone survey. *Dysphagia* **2015**, *30*, 114–120. [CrossRef] [PubMed]

3. Banda, K.J.; Chu, H.; Kang, X.L.; Liu, D.; Pien, L.-C.; Jen, H.-J.; Hsiao, S.-T.S.; Chou, K.-R. Prevalence of dysphagia and risk of pneumonia and mortality in acute stroke patients: A meta-analysis. *BMC Geriatr.* **2022**, *22*, 420. [CrossRef] [PubMed]

4. Speyer, R.; Cordier, R.; Kim, J.H.; Cocks, N.; Michou, E.; Wilkes-Gillan, S. Prevalence of drooling, swallowing, and feeding problems in cerebral palsy across the lifespan: A systematic review and meta-analyses. *Dev. Med. Child Neurol.* **2019**, *61*, 1249–1258. [CrossRef] [PubMed]

5. Rajati, F.; Ahmadi, N.; Naghibzadeh, Z.A.S.; Kazeminia, M. The global prevalence of oropharyngeal dysphagia in different populations: A systematic review and meta-analysis. *J. Transl. Med.* **2022**, *20*, 175. [CrossRef] [PubMed]

6. Rivelsrud, M.C.; Hartelius, L.; Bergström, L.; Løvstad, M.; Speyer, R. Prevalence of oropharyngeal dysphagia in adults in different healthcare settings: A systematic review and meta-analyses. *Dysphagia* **2023**, *38*, 76–121. [CrossRef]
cal contexts (from 31 countries and five continents) and professional backgrounds, study outcomes remain highly dependent on the subjective perspectives of included participants.

Further, Exploratory Principal Component factor analyses were limited by poor sample-to-variable ratios. Therefore, analyses were conducted for each type of factor separately (i.e., physiological impairments, risk factors, and prognostic factors), but not for all factors combined. Combining the total number of relevant factors (n = 53) as determined by the current participants (n = 69) would have required higher recruitment numbers of at least triple the number of factors (n ≥ 159) [18].

**5. Conclusions**

This Delphi study reports on the first attempt to develop an international consensus on a clinical decision tree for the disease trajectory of oropharyngeal dysphagia in adults taking into account physiological impairments of swallowing, risk factors for the development of complications from oropharyngeal dysphagia, and prognostic factors for treatment outcome. A total of 10 physiological impairments, 23 risk factors and 21 prognostic factors were identified as relevant factors in the clinical decision-making process. Factors considered to contribute most to the severity of oropharyngeal dysphagia were 'Aspiration', 'Incomplete ejection or failure to eject aspirated materials from the airways', 'Weak or absent cough', 'Choking' and 'Sensory deficits in oropharynx'. Future research is required to develop the current findings and confirm the domains based on relevant factors for clinical decision making, and those that contribute to the severity of oropharyngeal dysphagia, linking the current theoretical framework to clinical practice.

**Supplementary Materials:** The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/jcm12206572/s1, Supplementary File S1: Structure and content of Delphi rounds.

**Author Contributions:** Conceptualization: V.W. and R.S. Formal Analysis: R.S. and V.W. Project Administration: R.S., V.W., M.B. and G.S. Validation: R.S. and V.W. Writing—Review and Editing: R.S., V.W., M.B., E.C., C.D., S.M., G.S. and E.V. All authors have read and agreed to the published version of the manuscript.

**Funding:** This project was supported by the French National Research Agency (ANR-21-CE19-0057-01).

**Institutional Review Board Statement:** The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of Sud-Ouest et Outre Mer II (Comité de Protection des Personnes Sud-Ouest et Outre Mer II, France: 23.00117.000173; 16 March 2023).

**Informed Consent Statement:** Informed consent was obtained from all participants involved in the study.

**Data Availability Statement:** Data is available on request due to ethical restrictions.

**Conflicts of Interest:** The authors declare no conflict of interest.

**References**

1. Speyer, R.; Cordier, R.; Denman, D.; Windsor, C.; Krisciunas, G.P.; Smithard, D.; Heijnen, B.J. Development of Two Patient Self-Reported Measures on Functional Health Status (FOD) and Health-Related Quality of Life (QOD) in Adults with Oropharyngeal Dysphagia Using the Delphi Technique. *J. Clin. Med.* **2022**, *11*, 5920. [CrossRef] [PubMed]

2. Kertscher, B.; Speyer, R.; Fong, E.; Georgiou, A.M.; Smith, M. Prevalence of oropharyngeal dysphagia in the Netherlands: A telephone survey. *Dysphagia* **2015**, *30*, 114–120. [CrossRef] [PubMed]

3. Banda, K.J.; Chu, H.; Kang, X.L.; Liu, D.; Pien, L.-C.; Jen, H.-J.; Hsiao, S.-T.S.; Chou, K.-R. Prevalence of dysphagia and risk of pneumonia and mortality in acute stroke patients: A meta-analysis. *BMC Geriatr.* **2022**, *22*, 420. [CrossRef] [PubMed]

4. Speyer, R.; Cordier, R.; Kim, J.H.; Cocks, N.; Michou, E.; Wilkes-Gillan, S. Prevalence of drooling, swallowing, and feeding problems in cerebral palsy across the lifespan: A systematic review and meta-analyses. *Dev. Med. Child Neurol.* **2019**, *61*, 1249–1258. [CrossRef] [PubMed]

5. Rajati, F.; Ahmadi, N.; Naghibzadeh, Z.A.S.; Kazeminia, M. The global prevalence of oropharyngeal dysphagia in different populations: A systematic review and meta-analysis. *J. Transl. Med.* **2022**, *20*, 175. [CrossRef] [PubMed]

6. Rivelsrud, M.C.; Hartelius, L.; Bergström, L.; Løvstad, M.; Speyer, R. Prevalence of oropharyngeal dysphagia in adults in different healthcare settings: A systematic review and meta-analyses. *Dysphagia* **2023**, *38*, 76–121. [CrossRef]
7. Speyer, R.; Cordier, R.; Farneti, D.; Nascimento, W.; Pilz, W.; Verin, E.; Walshe, M.; Woisard, V. White paper by the European society for Swallowing Disorders: Screening and non-instrumental assessment for dysphagia in adults. *Dysphagia* **2022**, *37*, 333–349. [CrossRef] [PubMed]

8. Swan, K.; Cordier, R.; Brown, T.; Speyer, R. Psychometric properties of visuoperceptual measures of videofluoroscopic and fibre-endoscopic evaluations of swallowing: A systematic review. *Dysphagia* **2019**, *34*, 2–33. [CrossRef] [PubMed]

9. Starmer, H.; Edwards, J. Clinical Decision Making with Head and Neck Cancer Patients with Dysphagia. In *Seminars in Speech and Language*, Thieme Medical Publishers: New York, NY, USA, 2019.

10. Felix, C.C.; Joseph, M.E.; Daniels, S.K. Clinical Decision Making in Patients with Stroke-Related Dysphagia. In *Seminars in Speech and Language*, Thieme Medical Publishers: New York, NY, USA, 2019.

11. Jonsen, A.R.; Siegler, M.; Winslade, W.J. *Clinical Ethics: A Practical Approach to Ethical Decisions in Clinical Medicine*; McGraw-Hill: New York, NY, USA, 1985.

12. Toh, H.J.; Low, J.A.; Lim, Z.Y.; Lim, Y.; Siddiqui, S.; Tan, L. Jonsen's four topics approach as a framework for clinical ethics consultation. *Asian Bioeth. Rev.* **2018**, *10*, 37–51. [CrossRef] [PubMed]

13. Newman, R.; Vilardell, N.; Clavé, P.; Speyer, R. Effect of bolus viscosity on the safety and efficacy of swallowing and the kinematics of the swallow response in patients with oropharyngeal dysphagia: White paper by the European Society for Swallowing Disorders (ESSD). *Dysphagia* **2016**, *31*, 232–249. [CrossRef] [PubMed]

14. Boulkedid, R.; Abdoul, H.; Loustau, M.; Sibony, O.; Alberti, C. Using and reporting the Delphi method for selecting healthcare quality indicators: A systematic review. *PLoS ONE* **2011**, *6*, e20476. [CrossRef] [PubMed]

15. IBM Corporation. *IBM SPSS Statistics for Windows*; IBM Corporation: Armonk, NY, USA, 2017.

16. Diamond, I.R.; Grant, R.C.; Feldman, B.M.; Pencharz, P.B.; Ling, S.C.; Moore, A.M.; Wales, P.W. Defining consensus: A systematic review recommends methodologic criteria for reporting of Delphi studies. *J. Clin. Epidemiol.* **2014**, *67*, 401–409. [CrossRef] [PubMed]

17. Hsu, C.-C.; Sandford, B.A. The Delphi Technique: Making Sense of Consensus. *Pract. Assess. Res. Eval.* **2019**, *12*, 10.

18. Williams, B.; Onsman, A.; Brown, T. Exploratory factor analysis: A five-step guide for novices. *Australas. J. Paramed.* **2010**, *8*, 1–13. [CrossRef]

19. Terwee, C.B.; Prinsen, C.; Chiarotto, A.; De Vet, H.; Bouter, L.M.; Alonso, J.; Westerman, M.J.; Patrick, D.L.; Mokkink, L.B. *COSMIN Methodology for Assessing the Content Validity of PROMs–User Manual*; VU University Medical Center: Amsterdam, The Netherlands, 2018.

**Disclaimer/Publisher's Note:** The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.
7. Speyer, R.; Cordier, R.; Farneti, D.; Nascimento, W.; Pilz, W.; Verin, E.; Walshe, M.; Woisard, V. White paper by the European society for Swallowing Disorders: Screening and non-instrumental assessment for dysphagia in adults. *Dysphagia* **2022**, *37*, 333–349. [CrossRef] [PubMed]

8. Swan, K.; Cordier, R.; Brown, T.; Speyer, R. Psychometric properties of visuoperceptual measures of videofluoroscopic and fibre-endoscopic evaluations of swallowing: A systematic review. *Dysphagia* **2019**, *34*, 2–33. [CrossRef] [PubMed]

9. Starmer, H.; Edwards, J. Clinical Decision Making with Head and Neck Cancer Patients with Dysphagia. In *Seminars in Speech and Language*, Thieme Medical Publishers: New York, NY, USA, 2019.

10. Felix, C.C.; Joseph, M.E.; Daniels, S.K. Clinical Decision Making in Patients with Stroke-Related Dysphagia. In *Seminars in Speech and Language*, Thieme Medical Publishers: New York, NY, USA, 2019.

11. Jonsen, A.R.; Siegler, M.; Winslade, W.J. *Clinical Ethics: A Practical Approach to Ethical Decisions in Clinical Medicine*; McGraw-Hill: New York, NY, USA, 1985.

12. Toh, H.J.; Low, J.A.; Lim, Z.Y.; Lim, Y.; Siddiqui, S.; Tan, L. Jonsen's four topics approach as a framework for clinical ethics consultation. *Asian Bioeth. Rev.* **2018**, *10*, 37–51. [CrossRef] [PubMed]

13. Newman, R.; Vilardell, N.; Clavé, P.; Speyer, R. Effect of bolus viscosity on the safety and efficacy of swallowing and the kinematics of the swallow response in patients with oropharyngeal dysphagia: White paper by the European Society for Swallowing Disorders (ESSD). *Dysphagia* **2016**, *31*, 232–249. [CrossRef] [PubMed]

14. Boulkedid, R.; Abdoul, H.; Loustau, M.; Sibony, O.; Alberti, C. Using and reporting the Delphi method for selecting healthcare quality indicators: A systematic review. *PLoS ONE* **2011**, *6*, e20476. [CrossRef] [PubMed]

15. IBM Corporation. *IBM SPSS Statistics for Windows*; IBM Corporation: Armonk, NY, USA, 2017.

16. Diamond, I.R.; Grant, R.C.; Feldman, B.M.; Pencharz, P.B.; Ling, S.C.; Moore, A.M.; Wales, P.W. Defining consensus: A systematic review recommends methodologic criteria for reporting of Delphi studies. *J. Clin. Epidemiol.* **2014**, *67*, 401–409. [CrossRef] [PubMed]

17. Hsu, C.-C.; Sandford, B.A. The Delphi Technique: Making Sense of Consensus. *Pract. Assess. Res. Eval.* **2019**, *12*, 10.

18. Williams, B.; Onsman, A.; Brown, T. Exploratory factor analysis: A five-step guide for novices. *Australas. J. Paramed.* **2010**, *8*, 1–13. [CrossRef]

19. Terwee, C.B.; Prinsen, C.; Chiarotto, A.; De Vet, H.; Bouter, L.M.; Alonso, J.; Westerman, M.J.; Patrick, D.L.; Mokkink, L.B. *COSMIN Methodology for Assessing the Content Validity of PROMs–User Manual*; VU University Medical Center: Amsterdam, The Netherlands, 2018.

**Disclaimer/Publisher's Note:** The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.