# Sterically Bulky NHC Adducts of GaMe3 and InMe3 for H2 Activation and Lactide Polymerization

Anaëlle Bolley, Gilles Schnee, Lucas Thévenin, Béatrice Jacques, Samuel Dagorne

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Anaëlle Bolley, Gilles Schnee, Lucas Thévenin, Béatrice Jacques, Samuel Dagorne. Sterically Bulky NHC Adducts of GaMe3 and InMe3 for H2 Activation and Lactide Polymerization. Inorganics, 2018, 6 (1), pp.23. 10.3390/inorganics6010023 . hal-04868201

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Article

# Sterically Bulky NHC Adducts of GaMe₃ and InMe₃ for H₂ Activation and Lactide Polymerization

Anaëlle Bolley<sup>D</sup>, Gilles Schnee, Lucas Thévenin, Béatrice Jacques and Samuel Dagorne<sup>*</sup>

Institut de Chimie de Strasbourg, CNRS-Université de Strasbourg, 1 rue Blaise Pascal, 67000 Strasbourg, France; anaelle.bolley@etu.unistra.fr (A.B.); gilles.schnee@wanadoo.fr (G.S.); lucas.thevenin@lcc-toulouse.fr (L.T.); jacques@unistra.fr (B.J.)

* Correspondence: dagorne@unistra.fr; Tel.: +33-368-85-1530

Received: 22 December 2017; Accepted: 23 January 2018; Published: 25 January 2018

**Abstract:** The sterically bulky Ga(III) and In(III) (IPr\*)MMe₃ adducts (1 and 2) and (SItBu)MMe₃ adducts (3 and 4) (M = Ga, In; IPr\* = 1,3-bis{2,6-bis(diphenylmethyl)-4-methylphenyl}-1,3-dihydro-imidazol-2-ylidene; SItBu = 1,3-bis(1,1-dimethylethyl)-imidazolidin-2-ylidene) were prepared and structurally characterized, allowing an estimation of the steric hindrance of such Lewis pairs (yields in **1–4**: 92%, 90%, 73%, and 42%, respectively). While the IPr\* adducts **1** and **2** are robust species, the more severely congested SItBu adducts **3** and **4** are more reactive and exhibit a limited stability in solution. Adduct (SItBu)GaMe₃ (**3**) reacts quickly with H₂ at room temperature to afford the corresponding aminal product, 1,3-di-*tert*-butylimidazolidine (**5**), along with free GaMe₃. Such Frustrated Lewis Pair (FLP) reactivity constitutes the first instance of a H₂ activation involving a simple trialkyl GaR₃ species. Adduct **3** also mediates the ring-opening polymerization (ROP) of *rac*-lactide at room temperature to afford cyclic polylactide (PLA).

**Keywords:** N-heterocyclic carbene; gallium; indium; H₂ activation

## 1. Introduction

Thanks to their exceptional σ-donating properties and steric tunability, N-heterocyclic carbenes (NHCs) constitute a privileged class of supporting ligands for the stabilization of various metal complexes [1–5]. This has led to the widespread use of NHC-supported metal species in numerous research fields, notably in metal-based homogeneous catalysis and for the characterization of unusual organometallic motifs [6,7].

The coordination (and related reactivity studies) of NHCs to oxophilic and high-oxidation-state metal centers such as group 13 metals M(III) (M = Al, Ga, In) is currently attracting growing attention [8]. For the most part, this is due to the potential usefulness of the derived Lewis adducts for novel reactivity and/or small molecule activation, in particular through Frustrated Lewis Pair (FLP) reactivity [9]. FLP reactivity has attracted tremendous attention over the past few years thanks to the ability of sterically hindered Lewis pairs and FLPs to activate numerous polar/unsaturated substrates, including H₂ and CO₂ [9–11]. In the area of group 13 metal species, we and others have shown that sterically bulky group 13 metal Lewis adducts may display limited stability and readily isomerize to their “abnormal” counterparts for steric relief of (NHC)MMe₃ (Scheme 1, taking the example of adducts (ItBu)MMe₃) [12–14].

In the case of the bulky adduct (ItBu)AlMe₃, steric hindrance may also promote an unusual deprotonation of the AlMe₃ moiety by ItBu in the presence of Al₂Me₆ [15]. The ItBu/Al(iBu)₃ FLP system was also shown to activate H₂ at room temperature [13]. The reactivity of lower group 13 metal Ga(III)–/In(III)–NHC Lewis pairs has been less studied, though recent studies have detailed FLP activation of various polar substrates with an NHC/GaR₃ mixture (R = alkyl, carbyl) [16,17].
<figure><img src="image_3.png" /><figcaption>**Scheme 1.** Isomerization of *N*-heterocyclic carbene (NHC) adducts of group 13 metal complexes.</figcaption></figure>

To further probe the structural features and reactivity of sterically hindered Ga(III) and In(III) of the type NHC-MR₃ (R = alkyl, carbyl), the use of bulky NHCs IPr* and SitBu (IPr* = 1, 3-bis{2,6-bis(diphenylmethyl)-4-methylphenyl}-1,3-dihydro-imidazol-2-ylidene, SitBu = 1,3-bis(1,1-dimethylethyl)-imidazolidin-2-ylidene; Figure 1) for adduct formation with GaMe₃ and InMe₃ was studied.

<figure><img src="image_4.png" /><figcaption>**Figure 1.** Structures of NHCs IPr* and SitBu.</figcaption></figure>

We herein report the synthesis and structural characterization of such adducts and their reactivity with H₂, leading, as described below, to the first instance of H₂ activation by a simple NHC/GaMe₃ system. Preliminary results on the use of such compounds as lactide ring-opening polymerization catalysts are also discussed.

## 2. Results

### 2.1. Adducts (IPr*)MMe₃ (1, M = Ga; 2, M = In)

The superbulky NHC carbene IPr*, first reported by Marko and co-workers in 2010 [18], is frequently referred to as an "exceptionally bulky NHC with some flexible stericities" in several reports, and thus appeared to be a suitable candidate for our studies [19]. While a number of IPr*-supported complexes of late transition metals are known, the coordination of IPr* to oxophilic metal centers is thus far unreported.

The reaction of IPr*, which was prepared according to literature procedures, with a stoichiometric amount of MMe₃ (room temperature, toluene, 2 h) led to the quantitative formation of corresponding (IPr*)MMe₃ adducts (1, M = Ga; 2, M = In; Scheme 2), isolated in high yield as colorless solids (90% and 92% yield, respectively) [18,19]. The NMR data for 1 and 2 are consistent with the coordination of IPr* to the M(III) centers. In particular, the ¹³C NMR $C_{\text{carbene}}$ chemical shifts (δ 183.4 and 185.8 ppm for 1 and 2, respectively) lie in the expected range for NHC–Ga and NHC–In species and are significantly upfield shifted versus that of free IPr* (δ 220.0 ppm). Somewhat surprisingly given the steric properties of IPr*, adducts 1 and 2 are stable species in solution at room temperature, including in a coordinative solvent such as THF. Likewise, as monitored by ¹H NMR, species 1 and 2 are thermally robust and retain their integrity upon prolonged heating ($C_6D_6$, 48 h, 80 °C). The latter observations sharply contrast with the instability of their (ItBu)MMe₃ counterparts (Scheme 1).
<figure><img src="image_5.png" /><figcaption>**Scheme 2.** Synthesis of NHC adducts 1–4.</figcaption></figure>

As determined through X-ray crystallographic studies (XRD), the solid-state molecular structure of **2** confirmed the effective coordination of IPr\* to InMe₃, resulting in a four-coordinate In(III) adopting a distorted tetrahedral geometry and coplanar to the NHC heterocyclic ring (Figure 2). The In–C<sub>carbene</sub> bond distance (2.330(5) Å) in **2** is a bit longer than those in (IMes)InMe₃ and (IPr)InMe₃ (2.292(6) and 2.309(2) Å, respectively; IMes = 1,3-bis(2,4,6-trimethylphenyl)-1,3-dihydro-imidazol-2-ylidene; IPr = 1,3-bis{2,6-bis(1-methylethyl)phenyl})-1,3-dihydro-imidazol-2-ylidene), likely reflecting greater steric hindrance between the NHC and InMe₃ in **2** [20,21]. However, the shortest contacts between IPr\* and InMe₃ (H···H = 2.257 Å and C···H = 2.747 Å) remain close to the sum of the van der Waals (vdW) radii of the corresponding atoms, in line with no severe steric congestion in **2** and in agreement with the observed stability of adduct (IPr\*)InMe₃ in solution [22].

<figure><img src="image_6.png" /><figcaption>**Figure 2.** Molecular structure of adduct (IPr\*)InMe₃ (2, ORTEP view, the ellipsoids are at 50% probability level). Hydrogen atoms are omitted for clarity. Selected bond distances (Å): In(1)–C(1) = 2.330(5), C(1)–N(1) = 1.368(5), C(1)–N(2) = 1.355(6), C(2)–C(3) = 1.335(6).</figcaption></figure>

## 2.2. Adducts (StBu)MMe₃ (3, M = Ga; 4, M = In)

As earlier mentioned, the sterically hindered Lewis pairs (ItBu)MMe₃ (M = Ga, In) are unstable and rearrange to the corresponding C4-bonded isomers (*a*ItBu)MMe₃ (Scheme 1) [12–14]. To avoid such isomerization, the backbone-saturated carbene StBu, prepared according to a known procedure [23], was coordinated to GaMe₃ and InMe₃. Thus, reaction of StBu with one equiv. of GaMe₃/InMe₃ (pentane, –35 °C to room temperature, 30 min) led to the formation of species (StBu)MMe₃ (3, M = Ga; 4, M = In), which were isolated in moderate to good yields as highly air-sensitive colorless solids (73% and 42% yield, respectively). Unlike adducts 1 and 2, species 3 and 4 display a limited stability
in common solvents. While stable for days in benzene/toluene at room temperature (under inert atmosphere), they quickly decompose to unknown species in CH₂Cl₂ and THF at room temperature, in line with severely hindered Lewis pairs. The NMR data for **3** and **4** only display sharp resonances that are consistent with the proposed adduct formulation. Taking the example of the In(III) species **4**, the ¹H NMR spectrum contains a singlet resonance for the StBu-CH₂CH₂ moiety (δ 2.82 ppm, 4 H), upfield shielded relative to that in free StBu (δ 1.33 ppm), as well as a characteristic singlet in the In–Me region (δ 0.01 ppm, 9 H). No evidence for adduct dissociation is observable under the studied conditions for either **3** or **4** (C₆D₆, room temperature).

The solid-state molecular structures of adducts **3** and **4**, as established by XRD studies, confirmed the effective coordination of SitBu to the Ga(III) and In(III) metal centers, respectively (Figures 3 and 4). In species 3, the Ga–C<sub>carbene</sub> bond distance (2.195(2) Å) is significantly longer (≈ 0.07 Å) than those in related adducts (SIMes)GaMe<sub>3</sub> and (SIPr)GaMe<sub>3</sub> (2.124(5) and 2.137(2) Å, respectively) [21]. The latter, together with very short contacts between the NHC and the GaMe<sub>3</sub> moieties (shortest distances between SitBu and GaMe<sub>3</sub>: Ga···H = 2.581 Å, H···H = 2.009 Å, C···H = 2.550 Å) well below the sum of the vdW radii of the corresponding atoms, indicates that adduct **3** is severely crowded.

<figure><img src="image_7.png" /><figcaption>**Figure 3.** Molecular structure of adduct (SitBu)GaMe₃ (3, ORTEP view, the ellipsoids are at 50% probability level). Hydrogen atoms are omitted for clarity. Selected bond distances (Å): Ga(1)–C(1) = 2.195(2), C(1)–N(1) = 1.351(2), C(2)–C(2)' = 1.496(3).</figcaption></figure>

<figure><img src="image_8.png" /><figcaption>**Figure 4.** Molecular structure of adduct (SitBu)InMe₃ (4, ORTEP view, the ellipsoids are at 50% probability level). Hydrogen atoms are omitted for clarity. Selected bond distances (Å): In(1)–C(1) = 2.399(2), C(1)–N(1) = 1.350(2), C(2)–C(2)' = 1.500(4).</figcaption></figure>

The solid-state molecular structure of the In(III) adduct (SitBu)InMe₃ (4) features a longer In–C<sub>carbene</sub> bond distance (2.399(2) Å) versus those in (SIMes)InMe₃ and (SIPr)InMe₃ (2.304(8) and 2.342(2) Å, respectively) [20,21]. Comparing adducts **3** and **4**, the longer In–C<sub>carbene</sub> (versus Ga–C<sub>carbene</sub>)
bond distance decreases steric congestion in adduct **4** (versus **3**), as suggested by longer NHC/MMe₃ atom contacts in **4** (shortest contacts: In···H = 2.642 Å, H···H = 2.169 Å, C···H = 2.660 Å).

## 2.3. Reactivity of Adducts 1–4 with H₂

As sterically bulky Lewis adducts, the Ga- and In-based adducts are potential candidates for FLP reactivity. Ga- and In-based intermolecular FLP systems remain rare [16,17]. The reactivity of NHC adducts **1–4** with H₂ was therefore studied. In line with their stability and robustness in solution, IPr* adducts **1** and **2** were found to not react with H₂ (1.5 bar) even under prolonged heating (80 °C, C₆D₆, 48 h). In sharp contrast and satisfyingly, the most sterically hindered adduct (SItBu)GaMe₃ (**3**) exhibits FLP reactivity as it reacts quickly with H₂ (1.5 bar of H₂, room temperature, 5 min) to quantitatively yield the corresponding aminal derivative, 1,3-di-tert-butylimidazolidine (**5**), along with free GaMe₃, as deduced from ¹H NMR data (Scheme 3) [24]. Note that neither SItBu nor GaMe₃ alone react with H₂ under such conditions.

<figure><img src="image_9.png" /><figcaption>**Scheme 3.** Reaction of (SItBu)GaMe₃ with H₂.</figcaption></figure>

A similar H₂ activation was observed for the ItBu/Al(ιBu)₃ FLP system with H₂ [13]. The formation of product **5** is likely to proceed via a H₂ heterolytic cleavage (mediated to **3**) to yield transient salt species (SItBu–H)(HGaMe₃) (Scheme 4). The latter may then decompose via hydride transfer from the Ga center to the C2-imidazolinium atom of SItBu–H⁺ to afford **5** and regenerate GaMe₃. Consistent with the latter proposal, a SItBu/GaMe₃ mixture in a 1/0.4 ratio, i.e., with a substoichiometric amount of GaMe₃, also rapidly reacted and led to the quantitative conversion of SItBu to aminal **5** along with 0.4 equiv. of free GaMe₃ (Figure S8). Formally, GaMe₃ thus catalyzes the formation of **5** from **3** and H₂ (Scheme 4). Unlike its Ga(III) counterpart, the In(III) adduct **4** led to a complicated mixture of products upon reaction with H₂ (1.5 bar of H₂, room temperature, 3 h), among which only derivative **5** could be identified. The distinct reactivities towards H₂ of **3** and **4** versus **5** is certainly related to greater steric hindrance between the NHC and the MMe₃ fragments in **3** and **4**, prompting their easier dissociation and subsequent reactivity with H₂.

<figure><img src="image_10.png" /><figcaption>**Scheme 4.** GaMe₃-catalyzed hydrogenation of SItBu to afford imidazolidine **5** through Frustrated Lewis Pair (FLP) reactivity.</figcaption></figure>
## 2.4. Reactivity of Adducts 1–4 with Lactide

Over the past twenty years, group 13 metal alkoxide complexes supported by various ligand platforms have been widely and successfully investigated as ring-opening polymerization (ROP) initiators of cyclic esters/carbonates for the production of well-defined biodegradable poly-esters/-carbonates [25–27]. More recently, the polymerization of polar/unsaturated monomers, including cyclic esters, initiated by simple Al-based Lewis adducts has attracted attention [28,29]. Such a Lewis pair polymerization (LPP) relies on the cooperative activation of the monomer by the Lewis acid/base fragments and may be related to FLP reactivity.

The Lewis adducts **1–4** were thus tested as lactide (LA) ROP initiators (100 equiv. of *rac*-lactide (*rac*-LA), toluene, room temperature, 18 h). Adducts **1, 2, and 4** promote the ROP of *rac*-lactide to quantitatively yield ill-defined and broadly disperse polylactide (PLA), as deduced from Size Exclusion Chromatography (SEC) data (1000 < *M*<sub>n</sub> < 5000 g·mol<sup>-1</sup>, 3 < *D* < 4). On the contrary, narrow disperse PLA (*M*<sub>n</sub> = 4500 g·mol<sup>-1</sup>, *D* = 1.12) was quantitatively produced using the Ga adduct **3** as the ROP catalyst. The MALDI-TOF data of the prepared PLA display peaks that are equally spaced by 72 a.u., which is consistent with transesterified PLA (Figure S9). Also, both the mass values and the <sup>1</sup>H NMR data for the isolated PLA agree with the absence of any chain-end signals, and, therefore, with a cyclic PLA (Figure S10, SI). We recently reported the formation of cyclic PLA using related NHC–AlMe<sub>3</sub> Lewis pairs as lactide ROP catalysts [20]. It therefore seems likely that an analogous ROP mechanism is presently at play, involving a zwitterionic chain growing species that undergoes an intramolecular nucleophilic attack to form cyclic PLA and regenerate adduct **3** (Scheme 5).

<figure><img src="image_11.png" /><figcaption>**Scheme 5.** ROP of lactide mediated by adduct (SiBu)GaMe<sub>3</sub>.</figcaption></figure>

## 3. Materials and Methods

All experiments were carried out under N<sub>2</sub> using standard Schlenk techniques or in an M-Braun Unilab glovebox (M-Braun, Garching, Germany). Toluene and pentane were collected after being passed through drying columns and stored over activated molecular sieves (4 Å) for 24 h in a glovebox prior to use. Tetrahydrofuran was distilled over Na/benzophenone and stored over activated molecular sieves (4 Å) for 24 h in a glovebox prior to use. CD<sub>2</sub>Cl<sub>2</sub> and C<sub>6</sub>D<sub>6</sub> were distilled from CaH<sub>2</sub>, degassed under a N<sub>2</sub> flow, and stored over activated molecular sieves (4 Å) in a glovebox prior to use. GaMe<sub>3</sub> and InMe<sub>3</sub> were purchased from Strem Corporation (MA, USA). IPr* and 1,3-di-*tert*-butylimidazolin-2-ylidene (SiBu) [18,23]. The NMR spectra were recorded on Bruker AC 300, 400, or 500 MHz NMR spectrometers in Teflon-valved J-Young NMR tubes. <sup>1</sup>H and <sup>13</sup>C chemical shifts are reported versus SiMe<sub>4</sub> and were determined by reference to the residual <sup>1</sup>H and <sup>13</sup>C solvent peaks. Mass spectra were performed at the Mass Spectrometry Department of the University of Strasbourg. Mass spectra were acquired on a time-of-flight mass spectrometer (MALDI-TOF-TOF Autoflex II TOF-TOF, Bruker Daltonics, Bremen, Germany) equipped with a nitrogen laser (λ = 337 nm). An external multipoint calibration was carried out before each measurement with a standard peptide mixture and a standard protein mixture (depending on the mass range analysed). Scan accumulation and data processing were performed with FlexAnalysis 3.4 software (Bruker Daltonics, Bremen,
Germany). α-Cyano-4-hydroxy-cinnamic acid (CHCA), dithranol (DIT), or super-DHB (a 9/1 mixture of dihydroxybenzoid acid/2-hydroxy-5-methoxybenzoic acid) was used as the matrix for analysis of the prepared PLA samples. SEC analyses were performed on a SEC system equipped with a Shimadzu RID10A refractometer detector using HPLC-grade THF as an eluant (MilliporeSigma, MA, USA). Molecular weights and polydispersity indices (PDIs) were calculated using polystyrene standards. Molecular weight numbers ($M_n$) were corrected with the appropriate correcting factor (0.58) for the $M_n$ values.

### 3.1. Synthesis of (IPr*)$MMe_3$ (1, M = Ga; 2, M = In)

In a glovebox, a toluene solution of free carbene IPr* (400 mg, 0.438 mmol) was added dropwise via a pipette of toluene solution (10 mL) of $MMe_3$ (M= Ga or In, 0.438 mmol) under vigorous stirring. The latter mixture was stirred for 1h to room temperature then dried in vacuo to afford a colorless solid residue that was washed twice with pentane. It was further dried in vacuo to quantitatively afford the corresponding (IPr*)Ga$Me_3$ (1) and (IPr*)In$Me_3$ (2) adducts as NMR-pure colorless solids. **Data for compound 1.** 92% yield. X-ray quality crystals were grown from a pentane/toluene solution cooled at -35 °C. ¹H NMR (400 MHz, $C_6D_6$): $\delta = -0.08$ (s, 9H, Ga($CH_3$)$_3$), 1.78 (s, 6H, *p*-CH$_3$), 5.02 (s, 2H, CH*Im*), 5.69 (s, 4H, CHPh$_2$), 6.74-6.86 (m, 20H, CH$_Ph$), 7.04 (t, *J* = 7.5 Hz, 4H, CH$_Ph$), 7.14 (s, 4H, CH$_{Ar}$), 7.20 (t, *J* = 7.5 Hz, 8H, CH$_Ph$), 7.59 (d, *J* = 7.5 Hz, 8H, CH$_Ph$) ppm; $^{13}$C{$^1$H} NMR (125.8 MHz, $C_6D_6$): $\delta = -3.2$ (Ga($CH_3$)$_3$), 21.3 (*p*-CH$_3$), 52.2 (CHPh$_2$), 123.6 (CH$_{Im}$), 126.6, 127.2, 128.8, 129.8, 130.3, 131.1, 135.1, 140.0, 142.5, 143.2, 144.8, 183.4 ($C_{carbene}$) ppm. **Data for compound 2.** 90% yield. ¹H NMR (500 MHz, $C_6D_6$): $\delta = -0.11$ (s, 9H, In($CH_3$)$_3$), 1.77 (s, 6H, *p*-CH$_3$), 5.11 (s, 2H, CH$_{Im}$), 5.66 (s, 4H, CHPh$_2$), 6.75-6.88 (m, 20H, CH$_Ph$), 7.04 (t, *J* = 7.5 Hz, 4H, CH$_Ph$), 7.13 (s, 4H, CH$_{Ar}$), 7.19 (t, *J* = 7.5 Hz, 8H, CH$_Ph$), 7.52 (d, *J* = 7.5 Hz, 8H, CH$_Ph$) ppm; $^{13}$C{$^1$H} NMR (125.8 MHz, $C_6D_6$): $\delta = -7.7$ (In($CH_3$)$_3$), 21.3 (*p*-CH$_3$), 52.1 (CHPh$_2$), 124.1 (CH$_{Im}$), 126.7, 127.2, 128.4, 128.7, 129.8, 130.5, 131.0, 135.4, 140.1, 142.5, 143.2, 144.5, 185.8 ($C_{carbene}$) ppm.

### 3.2. (SItBu)$MMe_3$ (3, M = Ga; 4, M = In)

In a glovebox, a precooled pentane solution (-35 °C, 10 mL) of free carbene 1,3-di-*tert*-butylimidazolin-2-ylidene (SItBu, 100.0 mg, 0.55 mmol) was added dropwise via a pipette to a precooled (-35 °C) pentane solution (5 mL) of $MMe_3$ (M = Ga or In, 0.55 mmol) under vigorous stirring. The resulting colorless solution was allowed to warm to room temperature, provoking, upon warming, the massive precipitation of a colorless solid. The latter suspension was stirred for 10 min at room temperature after which it was filtered through a glass frit. The collected colorless solid was dried in vacuo to afford the corresponding adduct (SItBu)$MMe_3$ (3, M = Ga; 4, M = In). For both 3 and 4, X-ray quality crystals were grown from a saturated pentane solution cooled at -35 °C. **Data for compound 3.** 123 mg, 73% yield. ¹H NMR (300 MHz, $C_6D_6$): $\delta = -0.06$ (s, 9H, Ga($CH_3$)$_3$), 1.32 (s, 18H, tBu), 2.83 (s, 4H, ($CH_2$)$_{Im}$) ppm; $^{13}$C{$^1$H} NMR (75 MHz, $C_6D_6$): $\delta = -0.8$ (Ga($CH_3$)$_3$), 30.1 (C($CH_3$)$_3$), 44.7 (($CH_2$)$_{Im}$), 54.6 (C($CH_3$)$_3$), 232.1 ($C_{carbene}$) ppm. **Data for compound 4.** 79 mg, 42% yield. Anal. Calcd. for $C_{14}H_{31}InN$: C 49.13, H 9.13; found: C 49.24, H 9.12; ¹H NMR (300 MHz, $C_6D_6$): $\delta = -0.01$ (s, 9H, In($CH_3$)$_3$), 1.31 (s, 18H, tBu), 2.82 (s, 4H, ($CH_2$)$_{Im}$) ppm; $^{13}$C{$^1$H} NMR (75 MHz, $C_6D_6$): $\delta = -0.3$ (In($CH_3$)$_3$), 30.1 (C($CH_3$)$_3$), 45.0 (($CH_2$)$_{Im}$), 55.2 (C($CH_3$)$_3$), 223.3 ($C_{carbene}$) ppm.

### 3.3. Reaction of Adducts 1–4 with $H_2$

A Teflon-valved J-Young NMR tube containing a $C_6D_6$ solution of the desired adduct (NHC)$MMe_3$ (10 mg, NHC = IPr*, ItBu or SItBu, M = Ga or In, 0.5 mL,) was charged with $H_2$ (1.5 bar) at room temperature. The reaction was monitored by ¹H NMR spectroscopy until consumption of the starting (NHC)$MMe_3$ adduct was completed. In the case of adduct **3**, immediate and quantitative conversion to 1,3-di-*tert*-butylimidazolidine and free Ga$Me_3$ was observed.

**1,3-Di-tert-butylimidazolidine [24].** ¹H NMR (300 MHz, $C_6D_6$): $\delta = 1.00$ (s, 18H, tBu), 2.70 (s, 4H, -N-CH$_2$-CH$_2$-N-), 3.67 (s, 2H, N-CH$_2$-N).
### 3.4. Typical Procedure for the ROP of Lactide Initiated by Complexes 1–4

In a N₂-filled glovebox, the desired Lewis pair initiator (0.05 mmol) was charged in a vial equipped with a Teflon®-tight screw-cap and rac-lactide solution (100 equiv., [rac-lactide]₀ = 1 M, toluene) was added via a syringe all at once. The reaction mixture was stirred for 18 h at room temperature and subsequently was quenched with cold MeOH, provoking the precipitation of the polymer. The latter was then washed several times with MeOH, dried in vacuo and subsequently analyzed by SEC. In most cases, a MALDI-TOF MS analysis of the isolated polymers was performed. Catalytic runs under a given set of conditions were all duplicated.

## 4. Conclusions

The sterically bulky NHC-GaMe₃ and NHC-InMe₃ adducts (NHC = IPr*, SitBu) were prepared and characterized, and their level of steric congestion was assessed through structural analysis. All data agree with the IPr* adducts **1** and **2** being robust and stable adducts under various conditions. In contrast, the more severely congested SitBu adducts **3** and **4** are more reactive: this is best exemplified by the fast reaction of (SitBu)GaMe₃ (**3**) with H₂ at room temperature to afford the corresponding aminal product, the mechanism of which is currently being studied. Such an FLP reactivity constitutes the first instance of a H₂ activation involving GaMe₃, and further exemplifies the usefulness of bulky NHC ligands in FLP chemistry [30]. Adduct **3** was also found to mediate the ROP of rac-lactide at room temperature to afford cyclic PLA.

**Supplementary Materials:** The following are available online www.mdpi.com/2304-6740/6/1/23/s1, CIF files for adducts **2**, **3**, and **4** (CCDC 1813207, 1813208, and 1813209, respectively). NMR spectra of all compounds. MALDI-TOF and ¹H NMR data of the produced PLA.

**Acknowledgments:** The authors thank the CNRS and the University for financial support.

**Author Contributions:** Samuel Dagorne and Béatrice Jacques designed the experiments; Anaëlle Bolley, Gilles Schnee and Lucas Thévenin performed the experiments; Samuel Dagorne and Béatrice Jacques wrote the paper.

**Conflicts of Interest:** The authors declare no conflict of interest.

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