<table><caption>**Table 1 - Supplement 1.** Comparison of recent computational models for plasticity highlighting the experimental conditions implemented and the experiments in the hippocampus and cortex they reproduce. See **Table 1-Table Supplement 2** for additional details on experimental conditions of experimental works.</caption><thead><tr><th>Model</th><th>Graupner and Brunel (2012)</th><th>Ebner et al. (2019)</th><th>Jědrzejewska-Szmek et al. (2017)</th><th>Inglebert et al. (2020)</th><th>Chindemi et al. (2020)</th><th>Rodrigues et al. 2021</th></tr></thead><tbody><tr><th>model framework</th><td>extension of Shouval et al. (2002)</td><td>extension of Clopath et al. (2010) and modified from Hay et al. (2011)</td><td>modified from Evans et al. (2013)</td><td>extension of Graupner and Brunel (2012)</td><td>extension of Graupner and Brunel (2012)</td><td>extension of Graupner and Brunel (2012)</td></tr><tr><th>Parameter</th><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>temperature</th><td>absent</td><td>absent</td><td>temperature corrected ion channels (but not receptors)</td><td>no temperature control needed (experiments covered are at 30°C)</td><td>only in the GHK equation</td><td>temperature is selectable on the dendritic spine level for ion channels, receptor and the calcium cascade</td></tr><tr><th>development</th><td>absent</td><td>absent</td><td>absent</td><td>absent</td><td>absent</td><td>age is selectable and implemented by GABAr and NMDAr switch and BaP maturation</td></tr><tr><th>aCSF</th><td>absent</td><td>absent</td><td>absent</td><td>phenomenological changes in pre and post amplitudes to mimic extracellular calcium effects</td><td>in vivo or in vitro changes for release probability, calcium reversal potential on NMDAr-induced calcium influx</td><td>External Ca and Mg are selectable and affect release probability, reversal potential, NMDAr and VGCCs calcium current driving force</td></tr><tr><th>Plasticity experiments reproduced (quant. comparisons only)</th><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Sjöström et al. (2001)</th><td>X</td><td>X</td><td></td><td></td><td>X</td><td>X</td></tr><tr><th>Wittenberg and Wang (2006)</th><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Wang et al. (2005)</th><td>X</td><td>X</td><td></td><td></td><td>X</td><td></td></tr><tr><th>Sjöström and Häusser (2006)</th><td>X</td><td>X</td><td></td><td></td><td></td><td></td></tr><tr><th>Nevian and Sakmann (2006)</th><td>X</td><td>X</td><td></td><td></td><td></td><td></td></tr><tr><th>Letzkus et al. (2006)</th><td>X</td><td>X</td><td></td><td></td><td></td><td></td></tr><tr><th>Weber et al. (2016)</th><td>X</td><td>X</td><td></td><td></td><td></td><td></td></tr><tr><th>Fino et al. (2010)</th><td></td><td></td><td>X</td><td></td><td></td><td></td></tr><tr><th>Pawlak and Kerr (2008)</th><td></td><td></td><td>X</td><td></td><td></td><td></td></tr><tr><th>Shen et al. (2008)</th><td></td><td></td><td>X</td><td></td><td></td><td></td></tr><tr><th>Inglebert et al. (2020)</th><td></td><td></td><td></td><td>X</td><td>X</td><td>X</td></tr><tr><th>Markram et al. (1997)</th><td></td><td></td><td></td><td></td><td>X</td><td>X</td></tr><tr><th>Rodriguez-Moreno and Paulsen (2008)</th><td></td><td></td><td></td><td></td><td>X</td><td>X</td></tr><tr><th>EGger et al. (1999)</th><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Tigaret et al. (2016)</th><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Dudek and Bear (1992)</th><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Dudek and Bear (1993)</th><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Mizuno et al. (2001)</th><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Meredith et al. (2003)</th><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>O'Connor et al. (2005)</th><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>(not included due to space)</th><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Bittner et al. (2017)</th><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>(not included due to space)</th><td></td><td></td><td></td><td></td><td></td><td></td></tr></tbody></table>
<table><caption>**Table 1 - Supplement 2.** Comparison of the experimental conditions for the different reproduced datasets in Table 1-Table Supplement 1 covering experiments from neocortex, hippocampus and striatum</caption><thead><tr><th>Experimental work</th><th>Age (days)</th><th>[Ca<sup>2+</sup>]<sub>o</sub> (Mm)</th><th>[Mg<sup>2+</sup>]<sub>o</sub> (Mm)</th><th>Temperature (°C)</th></tr></thead><tbody><tr><td>Sjöström et al. (2001)</td><td>12-21</td><td>2.5</td><td>1</td><td>32-34</td></tr><tr><td>Wittenberg and Wang (2006)</td><td>14-21</td><td>2</td><td>1</td><td>24-30 or 30-34</td></tr><tr><td>Wang et al. (2005)</td><td>embryonic day 17-18</td><td>3</td><td>2</td><td>room</td></tr><tr><td>Sjöström and Häusser (2006)</td><td>14-21</td><td>2</td><td>1</td><td>32-35</td></tr><tr><td>Nevian and Sakmann (2006)</td><td>13-15</td><td>2</td><td>1</td><td>32-35</td></tr><tr><td>Letzkus et al. (2006)</td><td>21-42</td><td>2</td><td>1</td><td>34-35</td></tr><tr><td>Weber et al. (2016)</td><td>49-77</td><td>1.25</td><td>1.3 or 0.1</td><td>32-35</td></tr><tr><td>Fino et al. (2010)</td><td>15-21</td><td>2</td><td>1</td><td>34</td></tr><tr><td>Pawlak and Kerr (2008)</td><td>19-22</td><td>2.5</td><td>2</td><td>31-33</td></tr><tr><td>Shen et al. (2008)</td><td>19-26</td><td>2</td><td>1</td><td>room</td></tr><tr><td>Inglebert et al. (2020)</td><td>14-20</td><td>1.3-3.0</td><td>Ca/1.5</td><td>30</td></tr><tr><td>Markram et al. (1997)</td><td>14-16</td><td>2</td><td>1</td><td>32-34</td></tr><tr><td>Rodriguez-Moreno and Paulsen (2008)</td><td>9-14</td><td>2</td><td>2</td><td>room</td></tr><tr><td>Egger et al. (1999)</td><td>12-14</td><td>2</td><td>1</td><td>34-36</td></tr><tr><td>Tigaret et al. (2016)</td><td>50-55</td><td>2.5</td><td>1.3</td><td>35</td></tr><tr><td>Dudek and Bear (1992)</td><td>35</td><td>2.5</td><td>1.5</td><td>35</td></tr><tr><td>Dudek and Bear (1993)</td><td>7-35</td><td>2.5</td><td>1.5</td><td>35</td></tr><tr><td>Mizuno et al. (2001)</td><td>12-28</td><td>2.4</td><td>Mg-Free (most experiments)</td><td>30</td></tr><tr><td>Meredith et al. (2003)</td><td>9-45</td><td>2</td><td>2</td><td>24-28</td></tr><tr><td>O'Connor et al. (2005)</td><td>14-21</td><td>2</td><td>1</td><td>27.5-32</td></tr><tr><td>Bittner et al. (2017)</td><td>42-63</td><td>2</td><td>1</td><td>35</td></tr></tbody></table>

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