# COMT wt Allele

National Cancer Institute

## Source

National Cancer Institute. COMT wt Allele. NCI Thesaurus. Code C51044.

Human COMT wild-type allele is located in the vicinity of 22q11.21 and is approximately 27 kb in length. This allele, which encodes catechol O-methyltransferase protein, plays a role in the O-methylation-mediated inactivation of catecholamine neurotransmitters and catechol hormones. Defects in the COMT gene are associated with susceptibility to neurological disorders such as schizophrenia and bipolar disorder.