This work aims to determine the traditional uses of medicinal plants in the site of Djebel Djedoug located at the north of M’sila region (Algeria). This locate contains a rich and diversified medicinal flora. The ethnobotanical surveys carried out using the questionnaire cards made it possible to inventory 64 medicinal species belonging to 35 botanical families, and to collect as much information as possible about the traditional therapeutic uses of the local population. In addition, the results can be considered as a source of information for scientific research in the field of phytochemistry and pharmacology.