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**Conflict of Interest Statement:** H-JA reports personal fees from Ethypharm, grants, personal fees and non-financial support from Lundbeck, personal fees and non-financial support from D&A Pharma, other from Pfizer, other from Lilly, other from Indivior, other from AbbVie, other from Arbor Pharmaceuticals, other from Alkermes, other from Amygdala Neurosciences, outside the submitted work. PJ reports personal fees from Polpharma, outside the submitted work. AL-H reports grants and personal fees from Lundbeck, personal fees from Silence Therapeutics, other from Opiant, other from Lightlake, other from Britannia, grants from GSK, personal fees from Janssen-Cilag, personal fees from Pfizer, personal fees from Sanofi-Aventis, during the conduct of the study.

CM reports personal fees from Silence Therapeutics, outside the submitted work. BR reports personal fees from Ethypharm, outside the submitted work. WvdB reports personal fees from Lundbeck, personal fees from Eli Lilly, personal fees from Indivior, personal fees from Mundipharma, personal fees from Bioproject, personal fees from D&A Pharma, personal fees from Novartis, personal fees from Opiant Pharmaceuticals, outside the submitted work.

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2019 de Beaurepaire, Sinclair, Heydtmann, Addolorato, Aubin, Beraha, Caputo, Chick, de La Selle, Franchitto, Garbutt, Haber, Jaury, Lingford-Hughes, Morley, Müller, Owens, Pastor, Paterson, Pélissier, Rolland, Stafford, Thompson, van den Brink, Leggio and Agabio. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
sleep, neurobehavioral performance, and memory. Sleep (2012) 35:1071-83.
doi: 10.5665/sleep.1992

129. Orr WC, Goodrich S, Wright S, Shepherd K, Mellow M. The effect of baclofen on nocturnal gastroesophageal reflux and measures of sleep quality: a randomized, cross-over trial. *Neurogastroenterol Motil* (2012) 24:553-9, e253. doi: 10.1111/j.1365-2982.2012.01900.x

130. McGehee M, Hornyak JE, Lin C, Kelly BM. Baclofen-induced sexual dysfunction. *Neurology* (2006) 67:1097-8. doi: 10.1212/01.wnl.0000237332.25528.ac

131. Garbutt JC. Use of baclofen for alcohol use disorders in the United States. *Front Psychiatry* 9:448. doi: 10.3389/fpsyt.2018.00448

**Conflict of Interest Statement:** H-JA reports personal fees from Ethypharm, grants, personal fees and non-financial support from Lundbeck, personal fees and non-financial support from D&A Pharma, other from Pfizer, other from Lilly, other from Indivior, other from AbbVie, other from Arbor Pharmaceuticals, other from Alkermes, other from Amygdala Neurosciences, outside the submitted work. PJ reports personal fees from Polpharma, outside the submitted work. AL-H reports grants and personal fees from Lundbeck, personal fees from Silence Therapeutics, other from Opiant, other from Lightlake, other from Britannia, grants from GSK, personal fees from Janssen-Cilag, personal fees from Pfizer, personal fees from Sanofi-Aventis, during the conduct of the study.

CM reports personal fees from Silence Therapeutics, outside the submitted work. BR reports personal fees from Ethypharm, outside the submitted work. WvdB reports personal fees from Lundbeck, personal fees from Eli Lilly, personal fees from Indivior, personal fees from Mundipharma, personal fees from Bioproject, personal fees from D&A Pharma, personal fees from Novartis, personal fees from Opiant Pharmaceuticals, outside the submitted work.

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2019 de Beaurepaire, Sinclair, Heydtmann, Addolorato, Aubin, Beraha, Caputo, Chick, de La Selle, Franchitto, Garbutt, Haber, Jaury, Lingford-Hughes, Morley, Müller, Owens, Pastor, Paterson, Pélissier, Rolland, Stafford, Thompson, van den Brink, Leggio and Agabio. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.