# ICTV Virus Taxonomy Profile: Yueviridae 2023

Mart Krupovic, Yuri I Wolf, Eugene V Koonin, Jens H Kuhn

► To cite this version:

Mart Krupovic, Yuri I Wolf, Eugene V Koonin, Jens H Kuhn. ICTV Virus Taxonomy Profile: Yueviridae 2023. Journal of General Virology, 2023, 104 (10), pp.001904. 10.1099/jgv.0.001904. pasteur-04238148

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Submitted on 12 Oct 2023

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# ICTV Virus Taxonomy Profile: Yueviridae 2023

Mart Krupovic¹, Yuri I. Wolf², Eugene V. Koonin² and Jens H. Kuhn³,*

## Abstract

Yueviridae is a family of negative-sense RNA viruses with genomes of 7.8–8.2 kb that have been associated with crustaceans, insects, stramenopiles and plants. The yuevirid genome consist of two segments, each with at least one ORF. The large (L) segment ORF encodes a large protein containing an RNA-directed RNA polymerase domain. The small (S) segment ORF encodes a nucleocapsid protein. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Yueviridae, which is available at http://www.ictv.global/report/yueviridae.

<table><caption>**Table 1.** Characteristics of members of the family Yueviridae</caption><tr><td>Example</td><td>Bêihăi sesarmid crab virus 3 (L, KX884032; S, KX884033), species Yuyuevirus beihaiense, genus Yuyuevirus</td></tr><tr><td>Virion</td><td>Unknown</td></tr><tr><td>Genome</td><td>7.8–8.2 kb of bisegmented negative-sense RNA</td></tr><tr><td>Replication</td><td>Unknown</td></tr><tr><td>Translation</td><td>Unknown</td></tr><tr><td>Host range</td><td>Branchiopod, decapod and isopod crustaceans, dipteran and thysanopteran insects, lycopodiopsid and polypodiopsid plants and various macrophytes, and stramenopiles</td></tr><tr><td>Taxonomy</td><td>Realm Riboviria, kingdom Orthornavirae, phylum Negarnaviricota, class Yunchangviricetes, order Goujianvirales; the family includes the genus Yuyuevirus and two species</td></tr></table>

## VIRION

Unknown.

nucleocapsid protein structurally related to the homologues encoded by mononegavirals, in particular paramyxovirids.

## GENOME

The yuevirid genome comprises two segments of linear negative-sense RNA with a total length of 7.8–8.2 kb (large (L) segment, 6.6–6.9 kb; small (S) segment, 1.2–1.3 kb) [1–5] (Table 1, Fig. 1). The L segment ORF (L) encodes an RNA-directed RNA polymerase (RdRP) with a GDP : polyribonucleotidyltransferase (PRNTase) domain that is related to that of viruses in the order Mononegavirales, suggesting a similar capping mechanism. The S segment ORF (N) encodes a

## REPLICATION

Unknown.

## TAXONOMY

Current taxonomy: ictv.global/taxonomy. The family Yueviridae includes at least one genus and two species for the viruses Bêihăi sesarmid crab virus 3 and Shâhé yuevirus-like virus 1, found in unspecified sesarmid crabs (Crustacea: Decapoda) and freshwater isopods (Crustacea: Isopoda),

Received 27 September 2023; Accepted 27 September 2023; Published 11 October 2023

**Author affiliations:** ¹Institut Pasteur, Université Paris Cité, Paris 75015, France; ²National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA; ³Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA.

*Correspondence: Jens H. Kuhn, kuhnjens@mail.nih.gov

Keywords: ICTV Report; taxonomy; Yueviridae; yuyuevirus.

Abbreviation: L, large; N, nucleocapsid; RdRP, RNA-directed RNA polymerase; S, small.

001904 © 2023 The Authors

<figure><img src="image_5.png" /></figure>
<figure><img src="image_6.png" /><figcaption>**Fig. 1.** Genome organisation Bēihāi sesarmid crab virus 3. ORFs are coloured according to the predicted protein function [L, large protein gene encoding an RNA-directed RNA polymerase (RdRP) domain; N, gene encoding a nucleocapsid protein].</figcaption></figure>

respectively, in China [1] (Fig. 2). Unclassified yuevirids have been associated with diverse crustaceans and insects [6], stramenopiles [7–9], tracheophytes [3], and unspecified macrophytes [5]. Thus, the diversity of yuevirids is likely vastly underestimated [2, 4].

<figure><img src="image_7.png" /><figcaption>**Fig. 2.** Phylogenetic relationships of yuevirids. A phylogenetic tree was reconstructed for an alignment of the RdRP core domains of the ICTV Virus Metadata Resource (VMR) set of *Negarnaviricota* using the FastTree program. Branches for viruses other than yuevirids are collapsed according to order taxon; the complete tree is available in the full *Yueviridae* ICTV Report. Scale: substitutions/site.</figcaption></figure>

## References

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2. Käfer S, Paraskevopoulou S, Zirkel F, Wieseke N, Donath A, et al. Re-assessing the diversity of negative strand RNA viruses in insects. *PLoS Pathog* 2019;15:e1008224.

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## RESOURCES

The full ICTV Report on the family *Yueviridae* is available at: [ictv.global/report/yueviridae](https://ictv.global/report/yueviridae).

### Funding information

Production of this Profile, the ICTV Report and associated resources was supported by the Microbiology Society. This work was supported in part through the Laulima Government Solutions, LLC, prime contract with the U.S. National Institute of Allergy and Infectious Diseases (NIAID), under contract no. HHSN272201800013C. J.H.K. performed this work as an employee of Tunnell Government Services (TGS), a subcontractor of Laulima Government Solutions, LLC, under contract no. HHSN272201800013C. The content of this publication should not be interpreted as necessarily representing the official policies, either expressed or implied, of the U.S. Department of Health and Human Services or of the institutions and companies affiliated with the authors.

### Acknowledgements

We thank Stuart G. Siddell, Elliot J. Lefkowitz, Sead Sabanadzovic, Peter Simmonds, F. Murilo Zerbini, Evelien Adriaenssens, Mart Krupovic, Jens H. Kuhn, Luisa Rubino, Arvind Varsani (ICTV Report Editors) and Donald B. Smith (Managing Editor, ICTV Report). We thank Anya Crane (Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD, USA) for critically editing the manuscript.

### Conflicts of interest

The authors declare that there are no conflicts of interest.

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