# Verrucous carcinoma: a difficult differential diagnosis

Brendan Guegan

► To cite this version:

Brendan Guegan. Verrucous carcinoma: a difficult differential diagnosis. The Pan African Medical Journal, 2024, 47, pp.118. 10.11604/pamj.2024.47.118.37715. hal-05066669

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Submitted on 14 May 2025

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# Verrucous carcinoma: a difficult differential diagnosis

Brendan Guegan

**Corresponding author:** Brendan Guegan, Department of Oral Surgery, Nimes University Hospital, Nimes, France.
guegan.brendan@gmail.com

**Received:** 09 Oct 2022 - **Accepted:** 13 Nov 2022 - **Published:** 13 Mar 2024

**Keywords:** Verrucous carcinoma, verrous hyperplasia, proliferative verrucous leukoplasia

**Copyright:** Brendan Guegan et al. Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**Cite this article:** Brendan Guegan et al. Verrucous carcinoma: a difficult differential diagnosis. Pan African Medical Journal. 2024;47(118). 10.11604/pamj.2024.47.118.37715

**Available online at:** https://www.panafrican-med-journal.com/content/article/47/118/full

## Verrucous carcinoma: a difficult differential diagnosis

Brendan Guegan¹,&

¹Department of Oral Surgery, Nimes University Hospital, Nimes, France

⁸**Corresponding author**

Brendan Guegan, Department of Oral Surgery,
Nimes University Hospital, Nimes, France

## Image in medicine

A woman aged 85 years old was followed up for a giant verrucous carcinoma of the oral cavity. Looking at the patient's history, P16 was not over-expressed, Ki67 was expressed in basal layers, and no HPV was detected. Significant squamous hyperplasia of verrucous architecture with parakeratosis. Ulcerated areas are present on the surface. The chorion is the site of a moderate lymphocytic and plasma cell inflammatory infiltrate associated with numerous neutrophils in intraepithelial exocytosis with the formation of superficial micro-abscesses. Treatment with external radiotherapy, with an incomplete response rate, is to be completed with surgical removal. Difficult diagnosis between verrucous
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hyperplasia, proliferative verrucous leukoplasia and verrucous carcinoma. The essential rule in this type of lesion is the importance of deep and multiple biopsies, to rule out conventional

squamous cell carcinoma and to distinguish verrucous carcinoma from verrucous hyperplasia and proliferative verrucous leukoplasia.

<figure><img src="image_5.png" /><figcaption>**Figure 1:** verrucous carcinoma</figcaption></figure>