# Editorial: The roles of micro-RNAs in neuroendocrine systems

Lourdes Mounien, Kazuaki Nakamura, Fatiha Chigr, Fumihiko Maekawa

► To cite this version:

Lourdes Mounien, Kazuaki Nakamura, Fatiha Chigr, Fumihiko Maekawa. Editorial: The roles of micro-RNAs in neuroendocrine systems. Frontiers in Endocrinology, 2024, 15, 10.3389/fendo.2024.1349804. hal-04550901

HAL Id: hal-04550901

https://hal.inrae.fr/hal-04550901

Submitted on 18 Apr 2024

HAL is a multi-disciplinary open access
archive for the deposit and dissemination of sci-
entific research documents, whether they are pub-
lished or not. The documents may come from
teaching and research institutions in France or
abroad, or from public or private research centers.

L'archive ouverte pluridisciplinaire HAL, est
destinée au dépôt et à la diffusion de documents
scientifiques de niveau recherche, publiés ou non,
émanant des établissements d'enseignement et de
recherche français ou étrangers, des laboratoires
publics ou privés.

<figure><img src="image_1.png" /></figure>
# Editorial: The roles of micro-RNAs in neuroendocrine systems

Lourdes Mounien, Kazuaki Nakamura, Fatiha Chigr, Fumihiko Maekawa

<figure><img src="image_1.png" /></figure>

## To cite this version:

Lourdes Mounien, Kazuaki Nakamura, Fatiha Chigr, Fumihiko Maekawa. Editorial: The roles of micro-RNAs in neuroendocrine systems. Frontiers in Endocrinology, 2024, 15, 10.3389/fendo.2024.1349804. hal-04550901

HAL Id: hal-04550901

https://hal.inrae.fr/hal-04550901v1

Submitted on 18 Apr 2024

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.

L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

<figure><img src="image_2.png" /></figure>

Distributed under a Creative Commons Attribution 4.0 International License
<figure><img src="image_2.png" /></figure>

Check for updates

OPEN ACCESS

EDITED AND REVIEWED BY

Hubert Vaudry,
Universitéde Rouen,
France

*CORRESPONDENCE

Lourdes Mounien

<figure><img src="image_3.png" /></figure>

lourdes.mounien@univ-amu.fr

RECEIVED 05 December 2023

ACCEPTED 15 January 2024

PUBLISHED 24 January 2024

CITATION

Mounien L, Nakamura K, Chigr F and
Maekawa F (2024) Editorial: The roles of
micro-RNAs in neuroendocrine systems.
*Front. Endocrinol.* 15:1349804.
doi: 10.3389/fendo.2024.1349804

COPYRIGHT

© 2024 Mounien, Nakamura, Chigr and
Maekawa. This is an open-access article
distributed under the terms of the **Creative
Commons Attribution License (CC BY)**. The
use, distribution or reproduction in other
forums is permitted, provided the original
author(s) and the copyright owner(s) are
credited and that the original publication in
this journal is cited, in accordance with
accepted academic practice. No use,
distribution or reproduction is permitted
which does not comply with these terms.

# Editorial: The roles of micro-RNAs in neuroendocrine systems

Lourdes Mounien¹*, Kazuaki Nakamura², Fatiha Chigr³ and Fumihiko Maekawa⁴

¹Aix Marseille Université, C2VN, INRAE, INSERM, Marseille, France, ²National Research Institute for Child Health and Development, Tokyo, Japan, ³Université Sultan Moulay Slimane, Béni Mellal, Morocco, ⁴National Institute for Environmental Studies (NIES), Tsukuba, Japan

KEYWORDS

microRNA, neuroendocrine axis, neuroendocrine tumor, cancer, neuroendocrinological markers

## Editorial on the Research Topic

### The roles of micro-RNAs in neuroendocrine systems

Understanding the molecular mechanisms that regulate neuroendocrine systems is an exciting area of research, leading to a better comprehension of physiology and pathophysiology. In this context, evidence suggests that microRNAs, short non-coding RNAs, are involved in the regulation of hormone synthesis and release. This Research Topic, "*The Roles of MicroRNAs in Neuroendocrine Systems*", focuses on the latest discoveries and advances in the field of relationships between microRNAs and the neuroendocrine processes. The selected articles cover various aspects of microRNA-based regulation and explore its effect on neuroendocrine responses in both healthy and pathophysiological states.

## 1 MicroRNAs as neuroendocrine modulators

The chosen articles highlight the role of microRNAs as key modulators in neuroendocrine signaling cascades. These studies shed light on the fine-tuned regulation of hormone release and receptor expression which are crucial aspects of neuroendocrine systems.

## 2 Neuroendocrine dysfunction in pathological states

By means of different approaches, the studies presented in this Research Topic explore how dysregulation of microRNAs expression contributes to neuroendocrine dysfunction in various pathologies, such as adrenal or thyroid diseases (Hara et al., Mondin et al., Ma et al.).

These findings offer critical insights into potential therapeutic aspects.

Interestingly, one of the articles in this Research Topic suggests that environment factors, such as endocrine disruptors like phthalates, could lead to a dysregulation of microRNA expression (Nazzari et al.).
<figure><img src="image_3.png" /></figure>

Check for updates

OPEN ACCESS

EDITED AND REVIEWED BY

Hubert Vaudry,
Universitéde Rouen,
France

*CORRESPONDENCE

Lourdes Mounien

<figure><img src="image_4.png" /></figure>

lourdes.mounien@univ-amu.fr

RECEIVED 05 December 2023

ACCEPTED 15 January 2024

PUBLISHED 24 January 2024

CITATION

Mounien L, Nakamura K, Chigr F and
Maekawa F (2024) Editorial: The roles of
micro-RNAs in neuroendocrine systems.
*Front. Endocrinol.* 15:1349804.
doi: 10.3389/fendo.2024.1349804

COPYRIGHT

© 2024 Mounien, Nakamura, Chigr and
Maekawa. This is an open-access article
distributed under the terms of the **Creative
Commons Attribution License (CC BY)**. The
use, distribution or reproduction in other
forums is permitted, provided the original
author(s) and the copyright owner(s) are
credited and that the original publication in
this journal is cited, in accordance with
accepted academic practice. No use,
distribution or reproduction is permitted
which does not comply with these terms.

Editorial: The roles of micro-
RNAs in neuroendocrine systems

Lourdes Mounien¹*, Kazuaki Nakamura², Fatiha Chigr³ and Fumihiko Maekawa⁴

¹Aix Marseille Université, C2VN, INRAE, INSERM, Marseille, France, ²National Research Institute for Child Health and Development, Tokyo, Japan, ³Université Sultan Moulay Slimane, Béni Mellal, Morocco, ⁴National Institute for Environmental Studies (NIES), Tsukuba, Japan

KEYWORDS

microRNA, neuroendocrine axis, neuroendocrine tumor, cancer, neuroendocrinological
markers

Editorial on the Research Topic

The roles of micro-RNAs in neuroendocrine systems

Understanding the molecular mechanisms that regulate neuroendocrine systems is an exciting area of research, leading to a better comprehension of physiology and pathophysiology. In this context, evidence suggests that microRNAs, short non-coding RNAs, are involved in the regulation of hormone synthesis and release. This Research Topic, “*The Roles of MicroRNAs in Neuroendocrine Systems*”, focuses on the latest discoveries and advances in the field of relationships between microRNAs and the neuroendocrine processes. The selected articles cover various aspects of microRNA-based regulation and explore its effect on neuroendocrine responses in both healthy and pathophysiological states.

1 MicroRNAs as neuroendocrine modulators

The chosen articles highlight the role of microRNAs as key modulators in neuroendocrine signaling cascades. These studies shed light on the fine-tuned regulation of hormone release and receptor expression which are crucial aspects of neuroendocrine systems.

2 Neuroendocrine dysfunction in
pathological states

By means of different approaches, the studies presented in this Research Topic explore how dysregulation of microRNAs expression contributes to neuroendocrine dysfunction in various pathologies, such as adrenal or thyroid diseases (Hara et al., Mondin et al., Ma et al.).

These findings offer critical insights into potential therapeutic aspects.

Interestingly, one of the articles in this Research Topic suggests that environment factors, such as endocrine disruptors like phthalates, could lead to a dysregulation of microRNA expression (Nazzari et al.).
## 3 Crosstalk between microRNAs and hormones

These articles provide an understanding of how microRNAs contribute to the dynamic regulation of hormone release. As illustrated in the literature and in the articles of this Research Topic, circulating microRNAs are identified as biomarkers of hormonal dysfunction and may be associated with the pathophysiological heterogeneity of several diseases (Hara et al.).

## 4 Therapeutic implications and future directions

The data presented in this Research Topic make it evident that microRNAs play a role beyond basic research. Particularly, the articles indicate potential therapeutic applications where microRNA-based interventions could impact neuroendocrine treatment.

In conclusion, the articles published in this Research Topic provide valuable insights into understanding the impacts of microRNAs on neuroendocrine regulation. This Research Topic not only enhances our scientific knowledge but also indicates a medical perspective where modulating microRNAs expression could revolutionize our approach of neuroendocrine disorders. Particularly, microRNA therapy holds promise for patients dealing with therapeutic or drug resistance which are critical issues in many diseases.

## Author contributions

LM: Writing - original draft, Writing - review & editing.
KN: Writing - review & editing. FC: Writing - review & editing.
FM: Writing - review & editing.

## Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

## Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
## 3 Crosstalk between microRNAs and hormones

These articles provide an understanding of how microRNAs contribute to the dynamic regulation of hormone release. As illustrated in the literature and in the articles of this Research Topic, circulating microRNAs are identified as biomarkers of hormonal dysfunction and may be associated with the pathophysiological heterogeneity of several diseases (Hara et al.).

## 4 Therapeutic implications and future directions

The data presented in this Research Topic make it evident that microRNAs play a role beyond basic research. Particularly, the articles indicate potential therapeutic applications where microRNA-based interventions could impact neuroendocrine treatment.

In conclusion, the articles published in this Research Topic provide valuable insights into understanding the impacts of microRNAs on neuroendocrine regulation. This Research Topic not only enhances our scientific knowledge but also indicates a medical perspective where modulating microRNAs expression could revolutionize our approach of neuroendocrine disorders. Particularly, microRNA therapy holds promise for patients dealing with therapeutic or drug resistance which are critical issues in many diseases.

## Author contributions

LM: Writing – original draft, Writing – review & editing.

KN: Writing – review & editing. FC: Writing – review & editing.

FM: Writing – review & editing.

## Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

## Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.