# Keynote: Improved immunosensing using low dimensional carbon

Michael Holzinger

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## To cite this version:

Michael Holzinger. Keynote: Improved immunosensing using low dimensional carbon. 2nd European Biosensor Symposium (EBS 2019), Feb 2019, Florence (Italie), Italy. hal-04888513

HAL Id: hal-04888513

https://hal.science/hal-04888513v1

Submitted on 15 Jan 2025

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# Improved immunosensing using low dimensional carbon

Michael Holzinger¹

1) Département de Chimie Moléculaire, CNRS – University of Grenoble Alpes, 570 rue de la Chimie, 38041 Grenoble, France
e-mail: michael.holzinger@univ-grenoble-alpes.fr

The outstanding properties of nanostructured carbon such as carbon nanotubes or graphene made them a widely used material as electronic or electrochemical transducer in biosensor devices. In particular, carbon nanotubes (CNTs) possess the outstanding combination of nanowire morphology, biocompatibility and electronic properties. Furthermore, their ease and well-documented organic functionalization brings new properties to nanostructured electrodes [1-2] such as specific docking sites for biomolecules. Moreover, CNT films exhibits a high electroactive surface area due to the natural formation of highly porous three-dimensional networks, suitable for the anchoring of a high amount of bioreceptor units, leading consequently to high sensitivities. Furthermore, the controlled formation of porous structures with reproducible identical morphology could be obtained by an optimized filtration and transfer process leading to reliable high performing label free impedimetric immunosensors [3-4]

Since several years, monolayer graphene and related 2D carbon materials are shown as promising alternative to CNTs. The presented examples will show some interesting properties of monolayer graphene for SPR biosensors [5] while CNTs remains the material of choice for 3D matrices as receptor-transducer interface for electrochemical biosensor devices.

<figure><img src="image_3.png" /><figcaption>**Figure 1.** Illustrations of immunosensor setups using low dimensional carbon materials</figcaption></figure>

## References:

[1] M. Singh, M. Holzinger, O. Biloivan, S. Cosnier, *Carbon* **2013**, *61*, 349-356.

[2] M. Singh, M. Holzinger, M. Tabrizian, S. Cosnier, *Carbon* **2015**, *81*, 731-738.

[3] Q. Palomar, C. Gondran, R. Marks, S. Cosnier, M. Holzinger, *Electrochimica Acta* **2018**, *274*, 84-90.

[4] Q. Palomar, C. Gondran, M. Holzinger, R. Marks, S. Cosnier, *Biosens Bioelectron.* **2017**, *97*, 177-183.

[5] M. Singh, M. Holzinger, M. Tabrizian, S. Winters, N. C. Berner, S. Cosnier, G. S. Duesberg, *Journal of the American Chemical Society* **2015**, *137*, 2800-2803.