266. Appunni, S.; Rubens, M.; Ramamoorthy, V.; Anand, V.; Khandelwal, M.; Sharma, A. Biglycan: An Emerging Small Leucine-Rich Proteoglycan (SLRP) Marker and Its Clinicopathological Significance. *Mol. Cell Biochem.* **2021**, *476*, 3935–3950. [CrossRef] [PubMed]

267. Stern, R.; Asari, A.A.; Sugahara, K.N. HA Fragments: An Information-Rich System. *Eur. J. Cell Biol.* **2006**, *85*, 699–715. [CrossRef]

268. Berdiaki, A.; Neagu, M.; Spyridaki, I.; Kuskov, A.; Perez, S.; Nikitovic, D. HA and Reactive Oxygen Species Signaling-Novel Cues from the Matrix? *Antioxidants* **2023**, *12*, 824. [CrossRef]

269. Jiang, D.; Liang, J.; Fan, J.; Yu, S.; Chen, S.; Luo, Y.; Prestwich, G.D.; Mascarenhas, M.M.; Garg, H.G.; Quinn, D.A.; et al. Regulation of Lung Injury and Repair by Toll-like Receptors and HA. *Nat. Med.* **2005**, *11*, 1173–1179. [CrossRef]

270. Noble, P.W. HA and Its Catabolic Products in Tissue Injury and Repair. *Matrix Biol.* **2002**, *21*, 25–29. [CrossRef]

271. McKee, C.M.; Penno, M.B.; Cowman, M.; Burdick, M.D.; Strieter, R.M.; Bao, C.; Noble, P.W. HA (HA) Fragments Induce Chemokine Gene Expression in Alveolar Macrophages. The Role of HA Size and CD44. *J. Clin. Investig.* **1996**, *98*, 2403–2413. [CrossRef]

272. Mummert, M.E.; Mummert, D.; Edelbaum, D.; Hui, F.; Matsue, H.; Takashima, A. Synthesis and Surface Expression of HA by Dendritic Cells and Its Potential Role in Antigen Presentation. *J. Immunol.* **2002**, *169*, 4322–4331. [CrossRef]

273. Termeer, C.; Benedix, F.; Sleeman, J.; Fieber, C.; Voith, U.; Ahrens, T.; Miyake, K.; Freudenberg, M.; Galanos, C.; Simon, J.C. Oligosaccharides of HA Activate Dendritic Cells via Toll-like Receptor 4. *J. Exp. Med.* **2002**, *195*, 99–111. [CrossRef]

274. Monslow, J.; Govindaraju, P.; Puré, E. HA—A Functional and Structural Sweet Spot in the Tissue Microenvironment. *Front. Immunol.* **2015**, *6*, 231. [CrossRef] [PubMed]

275. Reitsma, S.; Slaaf, D.W.; Vink, H.; van Zandvoort, M.A.M.J.; oude Egbrink, M.G.A. The Endothelial Glycocalyx: Composition, Functions, and Visualization. *Pflug. Arch.* **2007**, *454*, 345–359. [CrossRef] [PubMed]

276. Kumar, A.V.; Katakam, S.K.; Urbanowitz, A.-K.; Gotte, M. Heparan Sulphate as a Regulator of Leukocyte Recruitment in Inflammation. *Curr. Protein. Pept. Sci.* **2015**, *16*, 77–86. [CrossRef] [PubMed]

277. Dragovich, M.A.; Genemaras, K.; Dailey, H.L.; Jedlicka, S.; Zhang, X.F. Dual Regulation of L-Selectin-Mediated Leukocyte Adhesion by Endothelial Surface Glycocalyx. *Cell Mol. Bioeng.* **2017**, *10*, 102–113. [CrossRef]

278. Norgard-Sumnicht, K.; Varki, A. Endothelial Heparan Sulfate Proteoglycans That Bind to L-Selectin Have Glucosamine Residues with Unsubstituted Amino Groups. *J. Biol. Chem.* **1995**, *270*, 12012–12024. [CrossRef]

279. Falanga, V. Wound Healing and Its Impairment in the Diabetic Foot. *Lancet* **2005**, *366*, 1736–1743. [CrossRef]

280. Evanko, S.P.; Tammi, M.I.; Tammi, R.H.; Wight, T.N. HA-Dependent Pericellular Matrix. *Adv. Drug. Deliv. Rev.* **2007**, *59*, 1351–1365. [CrossRef]

281. Schneider, A.; Francius, G.; Obeid, R.; Schwinté, P.; Hemmerlé, J.; Frisch, B.; Schaaf, P.; Voegel, J.-C.; Senger, B.; Picart, C. Polyelectrolyte Multilayers with a Tunable Young's Modulus: Influence of Film Stiffness on Cell Adhesion. *Langmuir* **2006**, *22*, 1193–1200. [CrossRef]

282. Fan, F.; Su, B.; Kolodychak, A.; Ekwueme, E.; Alderfer, L.; Saha, S.; Webber, M.J.; Hanjaya-Putra, D. Hyaluronic Acid Hydrogels with Phototunable Supramolecular Cross-Linking for Spatially Controlled Lymphatic Tube Formation. *ACS Appl. Mater. Interfaces* **2023**, *15*, 58181–58195. [CrossRef]

283. Rinaldi, E.; Baggi, F. LYVE-1 Is "on Stage" Now: An Emerging Player in Dendritic Cell Docking to Lymphatic Endothelial Cells. *Cell. Mol. Immunol.* **2018**, *15*, 663–665. [CrossRef]

284. Kieu, T.Q.; Tazawa, K.; Kawashima, N.; Noda, S.; Fujii, M.; Nara, K.; Hashimoto, K.; Han, P.; Okiji, T. Kinetics of LYVE-1-Positive M2-like Macrophages in Developing and Repairing Dental Pulp in Vivo and Their pro-Angiogenic Activity in Vitro. *Sci. Rep.* **2022**, *12*, 5176. [CrossRef] [PubMed]

285. Rosenberg, R.D.; Shworak, N.W.; Liu, J.; Schwartz, J.J.; Zhang, L. Heparan Sulfate Proteoglycans of the Cardiovascular System. Specific Structures Emerge but How Is Synthesis Regulated? *J. Clin. Investig.* **1997**, *99*, 2062–2070. [CrossRef] [PubMed]

286. Tarbell, J.M.; Simon, S.I.; Curry, F.-R.E. Mechanosensing at the Vascular Interface. *Annu. Rev. Biomed. Eng.* **2014**, *16*, 505–532. [CrossRef] [PubMed]

287. Florian, J.A.; Kosky, J.R.; Ainslie, K.; Pang, Z.; Dull, R.O.; Tarbell, J.M. Heparan Sulfate Proteoglycan Is a Mechanosensor on Endothelial Cells. *Circ. Res.* **2003**, *93*, e136–e142. [CrossRef] [PubMed]

288. Yao, Y.; Rabodzey, A.; Dewey, C.F. Glycocalyx Modulates the Motility and Proliferative Response of Vascular Endothelium to Fluid Shear Stress. *Am. J. Physiol. Heart Circ. Physiol.* **2007**, *293*, H1023–H1030. [CrossRef]

289. Giantsos-Adams, K.M.; Koo, A.J.-A.; Song, S.; Sakai, J.; Sankaran, J.; Shin, J.H.; Garcia-Cardena, G.; Dewey, C.F. Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation. *Cell. Mol. Bioeng.* **2013**, *6*, 160–174. [CrossRef]

290. Maiti, G.; Ashworth, S.; Choi, T.; Chakravarti, S. Molecular Cues for Immune Cells from Small Leucine-Rich Repeat Proteoglycans in Their Extracellular Matrix-Associated and Free Forms. *Matrix Biol.* **2023**, *123*, 48–58. [CrossRef]

291. Chen, C.; Zhao, S.; Karnad, A.; Freeman, J.W. The Biology and Role of CD44 in Cancer Progression: Therapeutic Implications. *J. Hematol. Oncol.* **2018**, *11*, 64. [CrossRef]

292. Bhattacharyya, M.; Jariyal, H.; Srivastava, A. Hyaluronic Acid: More than a Carrier, Having an Overpowering Extracellular and Intracellular Impact on Cancer. *Carbohydr. Polym.* **2023**, *317*, 121081. [CrossRef]

293. Amorim, S.; da Costa, D.S.; Mereiter, S.; Pashkuleva, I.; Reis, C.A.; Reis, R.L.; Pires, R.A. Multilayer Platform to Model the Bioactivity of Hyaluronic Acid in Gastric Cancer. *Mater. Sci. Eng. C* **2021**, *119*, 111616. [CrossRef]
294. Chen, J.; Meng, J.; Li, X.; Li, X.; Liu, Y.; Jin, C.; Zhang, L.; Hao, Z.; Chen, X.; Zhang, M.; et al. HA/CD44 Regulates the T Helper 1 Cells Differentiation by Activating Annexin A1/Akt/mTOR Signaling to Drive the Pathogenesis of EAP. *Front. Immunol.* **2022**, *13*, 875412. [CrossRef] [PubMed]

295. Wight, T.N.; Kang, I.; Evanko, S.P.; Harten, I.A.; Chang, M.Y.; Pearce, O.M.T.; Allen, C.E.; Frevert, C.W. Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation. *Front. Immunol.* **2020**, *11*, 512. [CrossRef] [PubMed]

296. Nadanaka, S.; Hashiguchi, T.; Kitagawa, H. Aberrant Glycosaminoglycan Biosynthesis by Tumor Suppressor EXT2 Deficiency Promotes Liver Inflammation and Tumorigenesis through Toll-like 4 Receptor Signaling. *FASEB J.* **2020**, *34*, 8385–8401. [CrossRef] [PubMed]

297. Hanoux, V.; Eguida, J.; Fleurot, E.; Levallet, J.; Bonnamy, P.-J. Increase in Hyaluronic Acid Degradation Decreases the Expression of Estrogen Receptor Alpha in MCF7 Breast Cancer Cell Line. *Mol. Cell. Endocrinol.* **2018**, *476*, 185–197. [CrossRef] [PubMed]

298. Jariyal, H.; Gupta, C.; Srivastava, A. Hyaluronic Acid Induction on Breast Cancer Stem Cells Unfolds Subtype Specific Variations in Stemness and Epithelial-to-Mesenchymal Transition. *Int. J. Biol. Macromol.* **2020**, *160*, 1078–1089. [CrossRef]

299. Li, L.; Qi, L.; Liang, Z.; Song, W.; Liu, Y.; Wang, Y.; Sun, B.; Zhang, B.; Cao, W. Transforming Growth Factor-B1 Induces EMT by the Transactivation of Epidermal Growth Factor Signaling through HA/CD44 in Lung and Breast Cancer Cells. *Int. J. Mol. Med.* **2015**, *36*, 113–122. [CrossRef]

300. Bourguignon, L.Y.W. Matrix HA Promotes Specific MicroRNA Upregulation Leading to Drug Resistance and Tumor Progression. *Int. J. Mol. Sci.* **2016**, *17*, 517. [CrossRef]

301. Afroz, R.; Zhou, Y.; Little, P.J.; Xu, S.; Mohamed, R.; Stow, J.; Kamato, D. Toll-like Receptor 4 Stimulates Gene Expression via Smad2 Linker Region Phosphorylation in Vascular Smooth Muscle Cells. *ACS Pharmacol. Transl. Sci.* **2020**, *3*, 524–534. [CrossRef]

302. Leppert, P.C.; Jayes, F.L.; Segars, J.H. The Extracellular Matrix Contributes to Mechanotransduction in Uterine Fibroids. *Obstet. Gynecol. Int.* **2014**, *2014*, 783289. [CrossRef]

303. Remodelling the Extracellular Matrix in Development and Disease—PubMed. Available online: https://pubmed.ncbi.nlm.nih.gov/25415508/ (accessed on 28 July 2024).

304. Zhu, L.; Liu, L.; Wang, A.; Liu, J.; Huang, X.; Zan, T. Positive Feedback Loops between Fibroblasts and the Mechanical Environment Contribute to Dermal Fibrosis. *Matrix Biol.* **2023**, *121*, 1–21. [CrossRef]

305. Li, S.; Li, C.; Zhang, Y.; He, X.; Chen, X.; Zeng, X.; Liu, F.; Chen, Y.; Chen, J. Targeting Mechanics-Induced Fibroblast Activation through CD44-RhoA-YAP Pathway Ameliorates Crystalline Silica-Induced Silicosis. *Theranostics* **2019**, *9*, 4993–5008. [CrossRef] [PubMed]

306. Zhao, Y.-Q.; Deng, X.-W.; Xu, G.-Q.; Lin, J.; Lu, H.-Z.; Chen, J. Mechanical Homeostasis Imbalance in Hepatic Stellate Cells Activation and Hepatic Fibrosis. *Front. Mol. Biosci.* **2023**, *10*, 1183808. [CrossRef] [PubMed]

307. Kimura, A.; Toyoki, Y.; Hakamada, K.; Yoshihara, S.; Sasaki, M. Characterization of Heparan Sulfate on Hepatocytes in Regenerating Rat Liver. *J. Hepato-Biliary-Pancreat. Surg.* **2008**, *15*, 608–614. [CrossRef] [PubMed]

308. Mead, T.J.; Bhutada, S.; Martin, D.R.; Apte, S.S. Proteolysis: A Key Post-Translational Modification Regulating Proteoglycans. *Am. J. Physiol. Cell. Physiol.* **2022**, *323*, C651–C665. [CrossRef] [PubMed]

309. Force-Dependent Breaching of the Basement Membrane—PMC. Available online: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328923/ (accessed on 28 July 2024).

310. Lachowski, D.; Cortes, E.; Rice, A.; Pinato, D.; Rombouts, K.; del Rio Hernandez, A. Matrix Stiffness Modulates the Activity of MMP-9 and TIMP-1 in Hepatic Stellate Cells to Perpetuate Fibrosis. *Sci. Rep.* **2019**, *9*, 7299. [CrossRef]

311. Kim, J.; Seki, E. HA in Liver Fibrosis: Basic Mechanisms, Clinical Implications, and Therapeutic Targets. *Hepatol. Commun.* **2023**, *7*, e0083. [CrossRef]

312. Masola, V.; Greco, N.; Gambaro, G.; Franchi, M.; Onisto, M. Heparanase as Active Player in Endothelial Glycocalyx Remodeling. *Matrix Biol. Plus* **2021**, *13*, 100097. [CrossRef]

313. Berdiaki, A.; Neagu, M.; Giatagana, E.-M.; Kuskov, A.; Tsatsakis, A.M.; Tzanakakis, G.N.; Nikitovic, D. Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy. *Biomolecules* **2021**, *11*, 395. [CrossRef]

314. Tzanakakis, G.; Giatagana, E.-M.; Kuskov, A.; Berdiaki, A.; Tsatsakis, A.; Neagu, M.; Nikitovic, D. Proteoglycans in the Pathogenesis of Hormone-Dependent Cancers: Mediators and Effectors. *Cancers* **2020**, *12*, 2401. [CrossRef]

315. Espinoza-Sánchez, N.A.; Götte, M. Role of Cell Surface Proteoglycans in Cancer Immunotherapy. *Semin. Cancer Biol.* **2020**, *62*, 48–67. [CrossRef]

316. Dong, Y.; Zheng, Q.; Wang, Z.; Lin, X.; You, Y.; Wu, S.; Wang, Y.; Hu, C.; Xie, X.; Chen, J.; et al. Higher Matrix Stiffness as an Independent Initiator Triggers Epithelial-Mesenchymal Transition and Facilitates HCC Metastasis. *J. Hematol. Oncol.* **2019**, *12*, 112. [CrossRef] [PubMed]

317. Pankova, D.; Chen, Y.; Terajima, M.; Schliekelman, M.J.; Baird, B.N.; Fahrenholtz, M.; Sun, L.; Gill, B.J.; Vadakkan, T.J.; Kim, M.P.; et al. Cancer-Associated Fibroblasts Induce a Collagen Cross-Link Switch in Tumor Stroma. *Mol. Cancer Res.* **2016**, *14*, 287–295. [CrossRef] [PubMed]

318. De Felice, D.; Alaimo, A. Mechanosensitive Piezo Channels in Cancer: Focus on Altered Calcium Signaling in Cancer Cells and in Tumor Progression. *Cancers* **2020**, *12*, 1780. [CrossRef] [PubMed]

319. Kalli, M.; Poskus, M.D.; Stylianopoulos, T.; Zervantonakis, I.K. Beyond Matrix Stiffness: Targeting Force-Induced Cancer Drug Resistance. *Trends Cancer* **2023**, *9*, 937–954. [CrossRef] [PubMed]
320. Zhang, T.; Jia, Y.; Yu, Y.; Zhang, B.; Xu, F.; Guo, H. Targeting the Tumor Biophysical Microenvironment to Reduce Resistance to Immunotherapy. *Adv. Drug Deliv. Rev.* **2022**, *186*, 114319. [CrossRef]

321. Tilsed, C.M.; Fisher, S.A.; Nowak, A.K.; Lake, R.A.; Lesterhuis, W.J. Cancer Chemotherapy: Insights into Cellular and Tumor Microenvironmental Mechanisms of Action. *Front. Oncol.* **2022**, *12*, 960317. [CrossRef]

322. Ahmed, N.; Abubaker, K.; Findlay, J.; Quinn, M. Epithelial Mesenchymal Transition and Cancer Stem Cell-like Phenotypes Facilitate Chemoresistance in Recurrent Ovarian Cancer. *Curr. Cancer Drug Targets* **2010**, *10*, 268–278. [CrossRef]

323. Darvishi, B.; Eisavand, M.R.; Majidzadeh-A, K.; Farahmand, L. Matrix Stiffening and Acquired Resistance to Chemotherapy: Concepts and Clinical Significance. *Br. J. Cancer* **2022**, *126*, 1253–1263. [CrossRef]

324. Meads, M.B.; Gatenby, R.A.; Dalton, W.S. Environment-Mediated Drug Resistance: A Major Contributor to Minimal Residual Disease. *Nat. Rev. Cancer.* **2009**, *9*, 665–674. [CrossRef]

325. Deng, M.; Lin, J.; Nowsheen, S.; Liu, T.; Zhao, Y.; Villalta, P.W.; Sicard, D.; Tschumperlin, D.J.; Lee, S.; Kim, J.; et al. Extracellular Matrix Stiffness Determines DNA Repair Efficiency and Cellular Sensitivity to Genotoxic Agents. *Sci. Adv.* **2020**, *6*, eabb2630. [CrossRef]

326. Baltes, F.; Pfeifer, V.; Silbermann, K.; Caspers, J.; Wantoch von Rekowski, K.; Schlesinger, M.; Bendas, G. β1-Integrin Binding to Collagen Type 1 Transmits Breast Cancer Cells into Chemoresistance by Activating ABC Efflux Transporters. *Biochim. Biophys. Acta Mol. Cell Res.* **2020**, *1867*, 118663. [CrossRef] [PubMed]

327. Bell-McGuinn, K.M.; Matthews, C.M.; Ho, S.N.; Barve, M.; Gilbert, L.; Penson, R.T.; Lengyel, E.; Palaparthy, R.; Gilder, K.; Vassos, A.; et al. A Phase II, Single-Arm Study of the Anti-A5β1 Integrin Antibody Volociximab as Monotherapy in Patients with Platinum-Resistant Advanced Epithelial Ovarian or Primary Peritoneal Cancer. *Gynecol. Oncol.* **2011**, *121*, 273–279. [CrossRef] [PubMed]

328. Haddad, T.; Qin, R.; Lupu, R.; Satele, D.; Eadens, M.; Goetz, M.P.; Erlichman, C.; Molina, J. A Phase I Study of Cilengitide and Paclitaxel in Patients with Advanced Solid Tumors. *Cancer Chemother. Pharmacol.* **2017**, *79*, 1221–1227. [CrossRef] [PubMed]

329. McNeel, D.G.; Eickhoff, J.; Lee, F.T.; King, D.M.; Alberti, D.; Thomas, J.P.; Friedl, A.; Kolesar, J.; Marnocha, R.; Volkman, J.; et al. Phase I Trial of a Monoclonal Antibody Specific for αvβ3 Integrin (MEDI-522) in Patients with Advanced Malignancies, Including an Assessment of Effect on Tumor Perfusion. *Clin. Cancer Res.* **2005**, *11*, 7851–7860. [CrossRef] [PubMed]

330. Tedla, Y.G.; Yano, Y.; Carnethon, M.; Greenland, P. Association Between Long-Term Blood Pressure Variability and 10-Year Progression in Arterial Stiffness: The Multiethnic Study of Atherosclerosis. *Hypertension* **2017**, *69*, 118–127. [CrossRef]

331. Goswami, R.; Cohen, J.; Sharma, S.; Zhang, D.X.; Lafyatis, R.; Bhawan, J.; Rahaman, S.O. TRPV4 ION Channel Is Associated with Scleroderma. *J. Investig. Dermatol.* **2017**, *137*, 962–965. [CrossRef]

332. Rahaman, S.O.; Grove, L.M.; Paruchuri, S.; Southern, B.D.; Abraham, S.; Niese, K.A.; Scheraga, R.G.; Ghosh, S.; Thodeti, C.K.; Zhang, D.X.; et al. TRPV4 Mediates Myofibroblast Differentiation and Pulmonary Fibrosis in Mice. *J. Clin. Investig.* **2014**, *124*, 5225–5238. [CrossRef]

333. Tang, W.; Fan, Y. SIRT6 as a Potential Target for Treating Insulin Resistance. *Life Sci.* **2019**, *231*, 116558. [CrossRef]

334. Li, L.; Wang, F.; Wei, X.; Liang, Y.; Cui, Y.; Gao, F.; Zhong, J.; Pu, Y.; Zhao, Y.; Yan, Z.; et al. Transient Receptor Potential Vanilloid 1 Activation by Dietary Capsaicin Promotes Urinary Sodium Excretion by Inhibiting Epithelial Sodium Channel α Subunit-Mediated Sodium Reabsorption. *Hypertension* **2014**, *64*, 397–404. [CrossRef]

335. Ma, L.; Zhong, J.; Zhao, Z.; Luo, Z.; Ma, S.; Sun, J.; He, H.; Zhu, T.; Liu, D.; Zhu, Z.; et al. Activation of TRPV1 Reduces Vascular Lipid Accumulation and Attenuates Atherosclerosis. *Cardiovasc. Res.* **2011**, *92*, 504–513. [CrossRef]

336. Xu, S.; Liu, B.; Yin, M.; Koroleva, M.; Mastrangelo, M.; Ture, S.; Morrell, C.N.; Zhang, D.X.; Fisher, E.A.; Jin, Z.G. A Novel TRPV4-Specific Agonist Inhibits Monocyte Adhesion and Atherosclerosis. *Oncotarget* **2016**, *7*, 37622–37635. [CrossRef] [PubMed]

337. Thorneloe, K.S.; Cheung, M.; Bao, W.; Alsaid, H.; Lenhard, S.; Jian, M.-Y.; Costell, M.; Maniscalco-Hauk, K.; Krawiec, J.A.; Olzinski, A.; et al. An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure. *Sci. Transl. Med.* **2012**, *4*, 159ra148. [CrossRef] [PubMed]

338. Goyal, N.; Skrdla, P.; Schroyer, R.; Kumar, S.; Fernando, D.; Oughton, A.; Norton, N.; Sprecher, D.L.; Cheriyan, J. Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects. *Am. J. Cardiovasc. Drugs* **2019**, *19*, 335–342. [CrossRef] [PubMed]

339. Mukherjee, P.; Rahaman, S.G.; Goswami, R.; Dutta, B.; Mahanty, M.; Rahaman, S.O. Role of Mechanosensitive Channels/Receptors in Atherosclerosis. *Am. J. Physiol. Cell Physiol.* **2022**, *322*, C927–C938. [CrossRef] [PubMed]

340. Puech, P.-H.; Bongrand, P. Mechanotransduction as a Major Driver of Cell Behaviour: Mechanisms, and Relevance to Cell Organization and Future Research. *Open Biol.* **2021**, *11*, 210256. [CrossRef] [PubMed]

341. Bongrand, P. Understanding How Cells Probe the World: A Preliminary Step towards Modeling Cell Behavior? *Int. J. Mol. Sci.* **2023**, *24*, 2266. [CrossRef] [PubMed]

342. LeCun, Y.; Bengio, Y.; Hinton, G. Deep Learning. *Nature.* **2015**, *521*, 436–444. [CrossRef]

343. Caicedo, J.C.; Cooper, S.; Heigwer, F.; Warchal, S.; Qiu, P.; Molnar, C.; Vasilevich, A.S.; Barry, J.D.; Bansal, H.S.; Kraus, O.; et al. Data-Analysis Strategies for Image-Based Cell Profiling. *Nat. Methods* **2017**, *14*, 849–863. [CrossRef]

344. Das, A.; Fischer, R.S.; Pan, D.; Waterman, C.M. YAP Nuclear Localization in the Absence of Cell-Cell Contact Is Mediated by a Filamentous Actin-Dependent, Myosin II- and Phospho-YAP-Independent Pathway during Extracellular Matrix Mechanosensing. *J. Biol. Chem.* **2016**, *291*, 6096–6110. [CrossRef]
345. Bonnevie, E.D.; Ashinsky, B.G.; Dekky, B.; Volk, S.W.; Smith, H.E.; Mauck, R.L. Cell Morphology and Mechanosensing Can Be Decoupled in Fibrous Microenvironments and Identified Using Artificial Neural Networks. *Sci. Rep.* **2021**, *11*, 5950. [CrossRef]

346. Wang, N.; Tytell, J.D.; Ingber, D.E. Mechanotransduction at a Distance: Mechanically Coupling the Extracellular Matrix with the Nucleus. *Nat. Rev. Mol. Cell Biol.* **2009**, *10*, 75–82. [CrossRef] [PubMed]

347. Gann, P.H.; Deaton, R.; Amatya, A.; Mohnani, M.; Rueter, E.E.; Yang, Y.; Ananthanarayanan, V. Development of a Nuclear Morphometric Signature for Prostate Cancer Risk in Negative Biopsies. *PLoS ONE* **2013**, *8*, e69457. [CrossRef] [PubMed]

348. Lee, R.Y.; Wu, Y.; Goh, D.; Tan, V.; Ng, C.W.; Lim, J.C.T.; Lau, M.C.; Yeong, J.P.S. Application of Artificial Intelligence to In Vitro Tumor Modeling and Characterization of the Tumor Microenvironment. *Adv. Healthc. Mater.* **2023**, *12*, e2202457. [CrossRef] [PubMed]

349. Binas, D.A.; Tzanakakis, P.; Economopoulos, T.L.; Konidari, M.; Bourgiotis, C.; Moulopoulos, L.A.; Matsopoulos, G.K. A Novel Approach for Estimating Ovarian Cancer Tissue Heterogeneity through the Application of Image Processing Techniques and Artificial Intelligence. *Cancers* **2023**, *15*, 1058. [CrossRef] [PubMed]

350. SubramanianBalachandar, V.; Islam, M.M.; Steward, R.L. A Machine Learning Approach to Predict Cellular Mechanical Stresses in Response to Chemical Perturbation. *Biophys. J.* **2023**, *122*, 3413–3424. [CrossRef] [PubMed]

**Disclaimer/Publisher's Note:** The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.