11. Bouzo, B.L.; Calvelo, M.; Martín-Pastor, M.; García-Fandiño, R.; De La Fuente, M. In Vitro—In Silico Modeling Approach to Rationally Designed Simple and Versatile Drug Delivery Systems. *J. Phys. Chem. B* **2020**, *124*, 5788–5800. [CrossRef] [PubMed]

12. Nagachinta, S.; Becker, G.; Dammicco, S.; Serrano, M.E.; Leroi, N.; Bahri, M.A.; Plenevaux, A.; Lemaire, C.; Lopez, R.; Luxen, A.; et al. Radiolabelling of Lipid-Based Nanocarriers with Fluorine-18 for in Vivo Tracking by PET. *Colloids Surf. B Biointerfaces* **2020**, *188*, 110793. [CrossRef] [PubMed]

13. Shao, S.; Zhu, Y.; Meng, T.; Liu, Y.; Hong, Y.; Yuan, M.; Yuan, H.; Hu, F. Targeting High Expressed α5β1 Integrin in Liver Metastatic Lesions To Resist Metastasis of Colorectal Cancer by RPM Peptide-Modified Chitosan-Stearic Micelles. *Mol. Pharm.* **2018**, *15*, 1653–1663. [CrossRef] [PubMed]

14. Benezra, M.; Hambardzumyan, D.; Penate-Medina, O.; Veach, D.R.; Pillarsetty, N.; Smith-Jones, P.; Phillips, E.; Ozawa, T.; Zanzonico, P.B.; Longo, V.; et al. Fluorine-Labeled Dasatinib Nanoformulations as Targeted Molecular Imaging Probes in a PDGFB-Driven Murine Glioblastoma Model. *Neoplasia* **2012**, *14*, 1132-1N8. [CrossRef] [PubMed]

15. Paulus, A.; Drude, N.; Nascimento, E.B.M.; Buhl, E.M.; Berbée, J.F.P.; Rensen, P.C.N.; Van Marken Lichtenbelt, W.D.; Mottaghy, F.M.; Bauwens, M. [¹⁸F]BODIPY-Triglyceride-Containing Chylomicron-like Particles as an Imaging Agent for Brown Adipose Tissue in Vivo. *Sci. Rep.* **2019**, *9*, 2706. [CrossRef] [PubMed]

16. Ducongé, F.; Pons, T.; Pestourie, C.; Hérin, L.; Thézé, B.; Gombert, K.; Mahler, B.; Hinnen, F.; Kühnast, B.; Dollé, F.; et al. Fluorine-18-Labeled Phospholipid Quantum Dot Micelles for in Vivo Multimodal Imaging from Whole Body to Cellular Scales. *Bioconjug. Chem.* **2008**, *19*, 1921–1926. [CrossRef]

17. Kallinen, A.M.; Sarparanta, M.P.; Liu, D.; Mäkilä, E.M.; Salonen, J.J.; Hirvonen, J.T.; Santos, H.A.; Airaksinen, A.J. In Vivo Evaluation of Porous Silicon and Porous Silicon Solid Lipid Nanocomposites for Passive Targeting and Imaging. *Mol. Pharm.* **2014**, *11*, 2876–2886. [CrossRef]

18. Reibel, A.T.; Müller, S.S.; Pektor, S.; Bausbacher, N.; Miederer, M.; Frey, H.; Rösch, F. Fate of Linear and Branched Polyether-Lipids In Vivo in Comparison to Their Liposomal Formulations by ¹⁸F-Radiolabeling and Positron Emission Tomography. *Biomacromolecules* **2015**, *16*, 842–851. [CrossRef]

19. Liu, Y.; Miao, Q.; Zou, P.; Liu, L.; Wang, X.; An, L.; Zhang, X.; Qian, X.; Luo, S.; Liang, G. Enzyme-Controlled Intracellular Self-Assembly of ¹⁸F Nanoparticles for Enhanced MicroPET Imaging of Tumor. *Theranostics* **2015**, *5*, 1058–1067. [CrossRef]

20. Qiu, L.; Li, K.; Dong, W.; Seimbille, Y.; Liu, Q.; Gao, F.; Lin, J. Tumor Microenvironment Responsive “Head-to-Foot” Self-Assembly Nanoplatform for Positron Emission Tomography Imaging in Living Subjects. *ACS Nano* **2021**, *15*, 18250–18259. [CrossRef]

21. Chen, M.; Chen, Z.; Castillo, J.B.; Cui, L.; Zhou, K.; Shen, B.; Xie, J.; Chin, F.T.; Rao, J. [18F]-C-SNAT4: An Improved Caspase-3-Sensitive Nanoaggregation PET Tracer for Imaging of Tumor Responses to Chemo- and Immunotherapies. *Eur. J. Nucl. Med. Mol. Imaging* **2021**, *48*, 3386–3399. [CrossRef] [PubMed]

22. Polyak, A.; Ross, T.L. Nanoparticles for SPECT and PET Imaging: Towards Personalized Medicine and Theranostics. *Curr. Med. Chem.* **2018**, *25*, 4328–4353. [CrossRef] [PubMed]

23. Wagener, K.; Worm, M.; Pektor, S.; Schinnerer, M.; Thiermann, R.; Miederer, M.; Frey, H.; Rösch, F. Comparison of Linear and Hyperbranched Polyether Lipids for Liposome Shielding by ¹⁸F-Radiolabeling and Positron Emission Tomography. *Biomacromolecules* **2018**, *19*, 2506–2516. [CrossRef] [PubMed]

24. Nsairat, H.; Khater, D.; Sayed, U.; Odeh, F.; Al Bawab, A.; Alshaer, W. Liposomes: Structure, Composition, Types, and Clinical Applications. *Heliyon* **2022**, *8*, e09394. [CrossRef] [PubMed]

25. Liu, P.; Chen, G.; Zhang, J. A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives. *Molecules* **2022**, *27*, 1372. [CrossRef] [PubMed]

26. Aranda-Lara, L.; Morales-Avila, E.; Luna-Gutiérrez, M.A.; Olivé-Alvarez, E.; Isaac-Olivé, K. Radiolabeled Liposomes and Lipoproteins as Lipidic Nanoparticles for Imaging and Therapy. *Chem. Phys. Lipids* **2020**, *230*, 104934. [CrossRef] [PubMed]

27. Man, F.; Gawne, P.J.; de Rosales, R.T.M. Nuclear Imaging of Liposomal Drug Delivery Systems: A Critical Review of Radiolabelling Methods and Applications in Nanomedicine. *Adv. Drug Deliv. Rev.* **2019**, *143*, 134–160. [CrossRef] [PubMed]

28. Wagener, K.; Bros, M.; Krumb, M.; Langhanki, J.; Pektor, S.; Worm, M.; Schinnerer, M.; Montermann, E.; Miederer, M.; Frey, H.; et al. Targeting of Immune Cells with Trimannosylated Liposomes. *Adv. Ther.* **2020**, *3*, 1900185. [CrossRef]

29. Urakami, T.; Akai, S.; Katayama, Y.; Harada, N.; Tsukada, H.; Oku, N. Novel Amphiphilic Probes for [¹⁸F]-Radiolabeling Preformed Liposomes and Determination of Liposomal Trafficking by Positron Emission Tomography. *J. Med. Chem.* **2007**, *50*, 6454–6457. [CrossRef]

30. Marik, J.; Tartis, M.S.; Zhang, H.; Fung, J.Y.; Kheirolomoom, A.; Sutcliffe, J.L.; Ferrara, K.W. Long-Circulating Liposomes Radiolabeled with [¹⁸F]Fluorodipalmitin ([18F]FDP). *Nucl. Med. Biol.* **2007**, *34*, 165–171. [CrossRef]

31. Urakami, T.; Kawaguchi, A.T.; Akai, S.; Hatanaka, K.; Koide, H.; Shimizu, K.; Asai, T.; Fukumoto, D.; Harada, N.; Tsukada, H.; et al. In Vivo Distribution of Liposome-Encapsulated Hemoglobin Determined by Positron Emission Tomography. *Artif. Organs* **2009**, *33*, 164–168. [CrossRef] [PubMed]

32. Hatanaka, K.; Asai, T.; Koide, H.; Kenjo, E.; Tsuzuku, T.; Harada, N.; Tsukada, H.; Oku, N. Development of Double-Stranded siRNA Labeling Method Using Positron Emitter and Its In Vivo Trafficking Analyzed by Positron Emission Tomography. *Bioconjug. Chem.* **2010**, *21*, 756–763. [CrossRef] [PubMed]

33. Fukuta, T.; Ishii, T.; Asai, T.; Nakamura, G.; Takeuchi, Y.; Sato, A.; Agato, Y.; Shimizu, K.; Akai, S.; Fukumoto, D.; et al. Real-Time Trafficking of PEGylated Liposomes in the Rodent Focal Brain Ischemia Analyzed by Positron Emission Tomography: Real-Time Trafficking of PEGylated Liposomes. *Artif. Organs* **2014**, *38*, 662–666. [CrossRef] [PubMed]
11. Bouzo, B.L.; Calvelo, M.; Martín-Pastor, M.; García-Fandiño, R.; De La Fuente, M. In Vitro—In Silico Modeling Approach to Rationally Designed Simple and Versatile Drug Delivery Systems. *J. Phys. Chem. B* **2020**, *124*, 5788–5800. [CrossRef] [PubMed]

12. Nagachinta, S.; Becker, G.; Dammicco, S.; Serrano, M.E.; Leroi, N.; Bahri, M.A.; Plenevaux, A.; Lemaire, C.; Lopez, R.; Luxen, A.; et al. Radiolabelling of Lipid-Based Nanocarriers with Fluorine-18 for in Vivo Tracking by PET. *Colloids Surf. B Biointerfaces* **2020**, *188*, 110793. [CrossRef] [PubMed]

13. Shao, S.; Zhu, Y.; Meng, T.; Liu, Y.; Hong, Y.; Yuan, M.; Yuan, H.; Hu, F. Targeting High Expressed α5β1 Integrin in Liver Metastatic Lesions To Resist Metastasis of Colorectal Cancer by RPM Peptide-Modified Chitosan-Stearic Micelles. *Mol. Pharm.* **2018**, *15*, 1653–1663. [CrossRef] [PubMed]

14. Benezra, M.; Hambardzumyan, D.; Penate-Medina, O.; Veach, D.R.; Pillarsetty, N.; Smith-Jones, P.; Phillips, E.; Ozawa, T.; Zanzonico, P.B.; Longo, V.; et al. Fluorine-Labeled Dasatinib Nanoformulations as Targeted Molecular Imaging Probes in a PDGFB-Driven Murine Glioblastoma Model. *Neoplasia* **2012**, *14*, 1132-1N8. [CrossRef] [PubMed]

15. Paulus, A.; Drude, N.; Nascimento, E.B.M.; Buhl, E.M.; Berbée, J.F.P.; Rensen, P.C.N.; Van Marken Lichtenbelt, W.D.; Mottaghy, F.M.; Bauwens, M. [¹⁸F]BODIPY-Triglyceride-Containing Chylomicron-like Particles as an Imaging Agent for Brown Adipose Tissue in Vivo. *Sci. Rep.* **2019**, *9*, 2706. [CrossRef] [PubMed]

16. Ducongé, F.; Pons, T.; Pestourie, C.; Hérin, L.; Thézé, B.; Gombert, K.; Mahler, B.; Hinnen, F.; Kühnast, B.; Dollé, F.; et al. Fluorine-18-Labeled Phospholipid Quantum Dot Micelles for in Vivo Multimodal Imaging from Whole Body to Cellular Scales. *Bioconjug. Chem.* **2008**, *19*, 1921–1926. [CrossRef]

17. Kallinen, A.M.; Sarparanta, M.P.; Liu, D.; Mäkilä, E.M.; Salonen, J.J.; Hirvonen, J.T.; Santos, H.A.; Airaksinen, A.J. In Vivo Evaluation of Porous Silicon and Porous Silicon Solid Lipid Nanocomposites for Passive Targeting and Imaging. *Mol. Pharm.* **2014**, *11*, 2876–2886. [CrossRef]

18. Reibel, A.T.; Müller, S.S.; Pektor, S.; Bausbacher, N.; Miederer, M.; Frey, H.; Rösch, F. Fate of Linear and Branched Polyether-Lipids In Vivo in Comparison to Their Liposomal Formulations by ¹⁸F-Radiolabeling and Positron Emission Tomography. *Biomacromolecules* **2015**, *16*, 842–851. [CrossRef]

19. Liu, Y.; Miao, Q.; Zou, P.; Liu, L.; Wang, X.; An, L.; Zhang, X.; Qian, X.; Luo, S.; Liang, G. Enzyme-Controlled Intracellular Self-Assembly of ¹⁸F Nanoparticles for Enhanced MicroPET Imaging of Tumor. *Theranostics* **2015**, *5*, 1058–1067. [CrossRef]

20. Qiu, L.; Li, K.; Dong, W.; Seimbille, Y.; Liu, Q.; Gao, F.; Lin, J. Tumor Microenvironment Responsive “Head-to-Foot” Self-Assembly Nanoplatform for Positron Emission Tomography Imaging in Living Subjects. *ACS Nano* **2021**, *15*, 18250–18259. [CrossRef]

21. Chen, M.; Chen, Z.; Castillo, J.B.; Cui, L.; Zhou, K.; Shen, B.; Xie, J.; Chin, F.T.; Rao, J. [18F]-C-SNAT4: An Improved Caspase-3-Sensitive Nanoaggregation PET Tracer for Imaging of Tumor Responses to Chemo- and Immunotherapies. *Eur. J. Nucl. Med. Mol. Imaging* **2021**, *48*, 3386–3399. [CrossRef] [PubMed]

22. Polyak, A.; Ross, T.L. Nanoparticles for SPECT and PET Imaging: Towards Personalized Medicine and Theranostics. *Curr. Med. Chem.* **2018**, *25*, 4328–4353. [CrossRef] [PubMed]

23. Wagener, K.; Worm, M.; Pektor, S.; Schinnerer, M.; Thiermann, R.; Miederer, M.; Frey, H.; Rösch, F. Comparison of Linear and Hyperbranched Polyether Lipids for Liposome Shielding by ¹⁸F-Radiolabeling and Positron Emission Tomography. *Biomacromolecules* **2018**, *19*, 2506–2516. [CrossRef] [PubMed]

24. Nsairat, H.; Khater, D.; Sayed, U.; Odeh, F.; Al Bawab, A.; Alshaer, W. Liposomes: Structure, Composition, Types, and Clinical Applications. *Heliyon* **2022**, *8*, e09394. [CrossRef] [PubMed]

25. Liu, P.; Chen, G.; Zhang, J. A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives. *Molecules* **2022**, *27*, 1372. [CrossRef] [PubMed]

26. Aranda-Lara, L.; Morales-Avila, E.; Luna-Gutiérrez, M.A.; Olivé-Alvarez, E.; Isaac-Olivé, K. Radiolabeled Liposomes and Lipoproteins as Lipidic Nanoparticles for Imaging and Therapy. *Chem. Phys. Lipids* **2020**, *230*, 104934. [CrossRef] [PubMed]

27. Man, F.; Gawne, P.J.; de Rosales, R.T.M. Nuclear Imaging of Liposomal Drug Delivery Systems: A Critical Review of Radiolabelling Methods and Applications in Nanomedicine. *Adv. Drug Deliv. Rev.* **2019**, *143*, 134–160. [CrossRef] [PubMed]

28. Wagener, K.; Bros, M.; Krumb, M.; Langhanki, J.; Pektor, S.; Worm, M.; Schinnerer, M.; Montermann, E.; Miederer, M.; Frey, H.; et al. Targeting of Immune Cells with Trimannosylated Liposomes. *Adv. Ther.* **2020**, *3*, 1900185. [CrossRef]

29. Urakami, T.; Akai, S.; Katayama, Y.; Harada, N.; Tsukada, H.; Oku, N. Novel Amphiphilic Probes for [¹⁸F]-Radiolabeling Preformed Liposomes and Determination of Liposomal Trafficking by Positron Emission Tomography. *J. Med. Chem.* **2007**, *50*, 6454–6457. [CrossRef]

30. Marik, J.; Tartis, M.S.; Zhang, H.; Fung, J.Y.; Kheirolomoom, A.; Sutcliffe, J.L.; Ferrara, K.W. Long-Circulating Liposomes Radiolabeled with [¹⁸F]Fluorodipalmitin ([18F]FDP). *Nucl. Med. Biol.* **2007**, *34*, 165–171. [CrossRef]

31. Urakami, T.; Kawaguchi, A.T.; Akai, S.; Hatanaka, K.; Koide, H.; Shimizu, K.; Asai, T.; Fukumoto, D.; Harada, N.; Tsukada, H.; et al. In Vivo Distribution of Liposome-Encapsulated Hemoglobin Determined by Positron Emission Tomography. *Artif. Organs* **2009**, *33*, 164–168. [CrossRef] [PubMed]

32. Hatanaka, K.; Asai, T.; Koide, H.; Kenjo, E.; Tsuzuku, T.; Harada, N.; Tsukada, H.; Oku, N. Development of Double-Stranded siRNA Labeling Method Using Positron Emitter and Its In Vivo Trafficking Analyzed by Positron Emission Tomography. *Bioconjug. Chem.* **2010**, *21*, 756–763. [CrossRef] [PubMed]

33. Fukuta, T.; Ishii, T.; Asai, T.; Nakamura, G.; Takeuchi, Y.; Sato, A.; Agato, Y.; Shimizu, K.; Akai, S.; Fukumoto, D.; et al. Real-Time Trafficking of PEGylated Liposomes in the Rodent Focal Brain Ischemia Analyzed by Positron Emission Tomography: Real-Time Trafficking of PEGylated Liposomes. *Artif. Organs* **2014**, *38*, 662–666. [CrossRef] [PubMed]
34. Emmetiere, F.; Irwin, C.; Viola-Villegas, N.T.; Longo, V.; Cheal, S.M.; Zanzonico, P.; Pillarsetty, N.; Weber, W.A.; Lewis, J.S.; Reiner, T. ¹⁸F-Labeled-Bioorthogonal Liposomes for In Vivo Targeting. *Bioconjug. Chem.* **2013**, *24*, 1784–1789. [CrossRef] [PubMed]

35. Zhang, H.; Kusunose, J.; Kheirolomoom, A.; Seo, J.W.; Qi, J.; Watson, K.D.; Lindfors, H.A.; Ruoslahti, E.; Sutcliffe, J.L.; Ferrara, K.W. Dynamic Imaging of Arginine-Rich Heart-Targeted Vehicles in a Mouse Model. *Biomaterials* **2008**, *29*, 1976–1988. [CrossRef]

36. Oku, N.; Yamashita, M.; Katayama, Y.; Urakami, T.; Hatanaka, K.; Shimizu, K.; Asai, T.; Tsukada, H.; Akai, S.; Kanazawa, H. PET Imaging of Brain Cancer with Positron Emitter-Labeled Liposomes. *Int. J. Pharm.* **2011**, *403*, 170–177. [CrossRef] [PubMed]

37. Jensen, A.T.I.; Binderup, T.; Andresen, T.L.; Kjær, A.; Rasmussen, P.H. PET Imaging of Liposomes Labeled with an [¹⁸F]-Fluorocholesteryl Ether Probe Prepared by Automated Radiosynthesis. *J. Liposome Res.* **2012**, *22*, 295–305. [CrossRef]

38. Rokka, J.; Snellman, A.; Kaasalainen, M.; Salonen, J.; Zona, C.; La Ferla, B.; Nicotra, F.; Re, F.; Masserini, M.; Forsback, S.; et al. ¹⁸F-Labeling Syntheses and Preclinical Evaluation of Functionalized Nanoliposomes for Alzheimer's Disease. *Eur. J. Pharm. Sci.* **2016**, *88*, 257–266. [CrossRef] [PubMed]

39. Lamichhane, N.; Dewkar, G.; Sundaresan, G.; Mahon, R.; Zweit, J. [¹⁸F]-Fluorinated Carboplatin and [¹¹In]-Liposome for Image-Guided Drug Delivery. *Int. J. Mol. Sci.* **2017**, *18*, 1079. [CrossRef]

40. Schieferstein, H.; Kelsch, A.; Reibel, A.; Koynov, K.; Barz, M.; Buchholz, H.; Bausbacher, N.; Thews, O.; Zentel, R.; Ross, T.L. ¹⁸F-Radiolabeling, Preliminary Evaluation of Folate-pHPMA Conjugates via PET. *Macromol. Biosci.* **2014**, *14*, 1396–1405. [CrossRef]

41. Herth, M.M.; Barz, M.; Moderegger, D.; Allmeroth, M.; Jahn, M.; Thews, O.; Zentel, R.; Rösch, F. Radioactive Labeling of Defined HPMA-Based Polymeric Structures Using [¹⁸F]FETos for In Vivo Imaging by Positron Emission Tomography. *Biomacromolecules* **2009**, *10*, 1697–1703. [CrossRef] [PubMed]

42. Allmeroth, M.; Moderegger, D.; Gündel, D.; Koynov, K.; Buchholz, H.-G.; Mohr, K.; Rösch, F.; Zentel, R.; Thews, O. HPMA-LMA Copolymer Drug Carriers in Oncology: An in Vivo PET Study to Assess the Tumor Line-Specific Polymer Uptake and Body Distribution. *Biomacromolecules* **2013**, *14*, 3091–3101. [CrossRef] [PubMed]

43. Goos, J.A.C.M.; Davydova, M.; Lengkeek, N.; Greguric, I.; Whittaker, M.R.; Quinn, J.F.; Baell, J.B.; Lewis, J.S.; Davis, T.P. pH-Responsive Polymers for Improving the Signal-to-Noise Ratio of Hypoxia PET Imaging with [¹⁸F]Fluoromisonidazole. *Macromol. Rapid Commun.* **2020**, *41*, 2000061. [CrossRef] [PubMed]

44. Sirianni, R.W.; Zheng, M.-Q.; Patel, T.R.; Shafbauer, T.; Zhou, J.; Saltzman, W.M.; Carson, R.E.; Huang, Y. Radiolabeling of Poly(Lactic- Co -Glycolic Acid) (PLGA) Nanoparticles with Biotinylated F-18 Prosthetic Groups and Imaging of Their Delivery to the Brain with Positron Emission Tomography. *Bioconjug. Chem.* **2014**, *25*, 2157–2165. [CrossRef] [PubMed]

45. Di Mauro, P.P.; Gómez-Vallejo, V.; Baz Maldonado, Z.; Llop Roig, J.; Borrós, S. Novel 18F Labeling Strategy for Polyester-Based NPs for in Vivo PET-CT Imaging. *Bioconjug. Chem.* **2015**, *26*, 582–592. [CrossRef] [PubMed]

46. Yamamoto, F.; Yamahara, R.; Makino, A.; Kurihara, K.; Tsukada, H.; Hara, E.; Hara, I.; Kizaka-Kondoh, S.; Ohkubo, Y.; Ozeki, E.; et al. Radiosynthesis and Initial Evaluation of ¹⁸F Labeled Nanocarrier Composed of Poly(L-Lactic Acid)-Block-Poly(Sarcosine) Amphiphilic Polydepsipeptide. *Nucl. Med. Biol.* **2013**, *40*, 387–394. [CrossRef] [PubMed]

47. Wang, Q.; Sun, Y.; Zhang, Z.; Duan, Y. Targeted Polymeric Therapeutic Nanoparticles: Design and Interactions with Hepatocellular Carcinoma. *Biomaterials* **2015**, *56*, 229–240. [CrossRef]

48. Kampmann, A.; Luksin, M.; Pretzer, I.; Weberskirch, R. Formation of Well-Defined Polymer Particles in the Sub-100 nm Size Range by Using Amphiphilic Block Copolymer Surfactants and a Microemulsion Approach. *Macromol. Chem. Phys.* **2016**, *217*, 1704–1711. [CrossRef]

49. Berke, S.; Kampmann, A.-L.; Wuest, M.; Bailey, J.J.; Glowacki, B.; Wuest, F.; Jurkschat, K.; Weberskirch, R.; Schirrmacher, R. ¹⁸F-Radiolabeling and In Vivo Analysis of SiFA-Derivatized Polymeric Core–Shell Nanoparticles. *Bioconjug. Chem.* **2018**, *29*, 89–95. [CrossRef]

50. Matson, J.B.; Grubbs, R.H. Synthesis of Fluorine-18 Functionalized Nanoparticles for Use as in Vivo Molecular Imaging Agents. *J. Am. Chem. Soc.* **2008**, *130*, 6731–6733. [CrossRef]

51. Dias, A.P.; Da Silva Santos, S.; Da Silva, J.V.; Parise-Filho, R.; Igne Ferreira, E.; Seoud, O.E.; Giarolla, J. Dendrimers in the Context of Nanomedicine. *Int. J. Pharm.* **2020**, *573*, 118814. [CrossRef] [PubMed]

52. Zhao, L.; Zhu, M.; Li, Y.; Xing, Y.; Zhao, J. Radiolabeled Dendrimers for Nuclear Medicine Applications. *Molecules* **2017**, *22*, 1350. [CrossRef] [PubMed]

53. Trembleau, L.; Simpson, M.; Cheyne, R.W.; Escofet, I.; Appleyard, M.V.C.A.L.; Murray, K.; Sharp, S.; Thompson, A.M.; Smith, T.A.D. Development of ¹⁸F-Fluorinatable Dendrons and Their Application to Cancer Cell Targeting. *N. J. Chem.* **2011**, *35*, 2496. [CrossRef]

54. Zhou, D.; Kim, S.H.; Carroll, V.M.; Dence, C.S.; Katzenellenbogen, J.A. Utilizing Electrostatic Interactions to Facilitate F-18 Radiolabeling of Poly(Amido)amine (PAMAM) Dendrimers. *Org. Biomol. Chem.* **2014**, *12*, 8696–8701. [CrossRef] [PubMed]

55. Carlson, M.L.; Jackson, I.M.; Azevedo, E.C.; Reyes, S.T.; Alam, I.S.; Kellow, R.; Castillo, J.B.; Nagy, S.C.; Sharma, R.; Brewer, M.; et al. Development and Initial Assessment of [¹⁸F]OP-801: A Novel Hydroxyl Dendrimer PET Tracer for Preclinical Imaging of Innate Immune Activation in the Whole Body and Brain. *Mol. Imaging Biol.* **2023**, *25*, 1063–1072. [CrossRef] [PubMed]

56. Jackson, I.M.; Carlson, M.L.; Beinat, C.; Malik, N.; Kalita, M.; Reyes, S.; Azevedo, E.C.; Nagy, S.C.; Alam, I.S.; Sharma, R.; et al. Clinical Radiosynthesis and Translation of [¹⁸F]OP-801: A Novel Radiotracer for Imaging Reactive Microglia and Macrophages. *ACS Chem. Neurosci.* **2023**, *14*, 2416–2424. [CrossRef] [PubMed]
34. Emmetiere, F.; Irwin, C.; Viola-Villegas, N.T.; Longo, V.; Cheal, S.M.; Zanzonico, P.; Pillarsetty, N.; Weber, W.A.; Lewis, J.S.; Reiner, T. ¹⁸F-Labeled-Bioorthogonal Liposomes for In Vivo Targeting. *Bioconjug. Chem.* **2013**, *24*, 1784–1789. [CrossRef] [PubMed]

35. Zhang, H.; Kusunose, J.; Kheirolomoom, A.; Seo, J.W.; Qi, J.; Watson, K.D.; Lindfors, H.A.; Ruoslahti, E.; Sutcliffe, J.L.; Ferrara, K.W. Dynamic Imaging of Arginine-Rich Heart-Targeted Vehicles in a Mouse Model. *Biomaterials* **2008**, *29*, 1976–1988. [CrossRef]

36. Oku, N.; Yamashita, M.; Katayama, Y.; Urakami, T.; Hatanaka, K.; Shimizu, K.; Asai, T.; Tsukada, H.; Akai, S.; Kanazawa, H. PET Imaging of Brain Cancer with Positron Emitter-Labeled Liposomes. *Int. J. Pharm.* **2011**, *403*, 170–177. [CrossRef] [PubMed]

37. Jensen, A.T.I.; Binderup, T.; Andresen, T.L.; Kjær, A.; Rasmussen, P.H. PET Imaging of Liposomes Labeled with an [¹⁸F]-Fluorocholesteryl Ether Probe Prepared by Automated Radiosynthesis. *J. Liposome Res.* **2012**, *22*, 295–305. [CrossRef]

38. Rokka, J.; Snellman, A.; Kaasalainen, M.; Salonen, J.; Zona, C.; La Ferla, B.; Nicotra, F.; Re, F.; Masserini, M.; Forsback, S.; et al. ¹⁸F-Labeling Syntheses and Preclinical Evaluation of Functionalized Nanoliposomes for Alzheimer's Disease. *Eur. J. Pharm. Sci.* **2016**, *88*, 257–266. [CrossRef] [PubMed]

39. Lamichhane, N.; Dewkar, G.; Sundaresan, G.; Mahon, R.; Zweit, J. [¹⁸F]-Fluorinated Carboplatin and [¹¹In]-Liposome for Image-Guided Drug Delivery. *Int. J. Mol. Sci.* **2017**, *18*, 1079. [CrossRef]

40. Schieferstein, H.; Kelsch, A.; Reibel, A.; Koynov, K.; Barz, M.; Buchholz, H.; Bausbacher, N.; Thews, O.; Zentel, R.; Ross, T.L. ¹⁸F-Radiolabeling, Preliminary Evaluation of Folate-HPMA Conjugates via PET. *Macromol. Biosci.* **2014**, *14*, 1396–1405. [CrossRef]

41. Herth, M.M.; Barz, M.; Moderegger, D.; Allmeroth, M.; Jahn, M.; Thews, O.; Zentel, R.; Rösch, F. Radioactive Labeling of Defined HPMA-Based Polymeric Structures Using [¹⁸F]FETos for In Vivo Imaging by Positron Emission Tomography. *Biomacromolecules* **2009**, *10*, 1697–1703. [CrossRef] [PubMed]

42. Allmeroth, M.; Moderegger, D.; Gündel, D.; Koynov, K.; Buchholz, H.-G.; Mohr, K.; Rösch, F.; Zentel, R.; Thews, O. HPMA-LMA Copolymer Drug Carriers in Oncology: An in Vivo PET Study to Assess the Tumor Line-Specific Polymer Uptake and Body Distribution. *Biomacromolecules* **2013**, *14*, 3091–3101. [CrossRef] [PubMed]

43. Goos, J.A.C.M.; Davydova, M.; Lengkeek, N.; Greguric, I.; Whittaker, M.R.; Quinn, J.F.; Baell, J.B.; Lewis, J.S.; Davis, T.P. pH-Responsive Polymers for Improving the Signal-to-Noise Ratio of Hypoxia PET Imaging with [¹⁸F]Fluoromisonidazole. *Macromol. Rapid Commun.* **2020**, *41*, 2000061. [CrossRef] [PubMed]

44. Sirianni, R.W.; Zheng, M.-Q.; Patel, T.R.; Shafbauer, T.; Zhou, J.; Saltzman, W.M.; Carson, R.E.; Huang, Y. Radiolabeling of Poly(Lactic- Co -Glycolic Acid) (PLGA) Nanoparticles with Biotinylated F-18 Prosthetic Groups and Imaging of Their Delivery to the Brain with Positron Emission Tomography. *Bioconjug. Chem.* **2014**, *25*, 2157–2165. [CrossRef] [PubMed]

45. Di Mauro, P.P.; Gómez-Vallejo, V.; Baz Maldonado, Z.; Llop Roig, J.; Borrós, S. Novel 18F Labeling Strategy for Polyester-Based NPs for in Vivo PET-CT Imaging. *Bioconjug. Chem.* **2015**, *26*, 582–592. [CrossRef] [PubMed]

46. Yamamoto, F.; Yamahara, R.; Makino, A.; Kurihara, K.; Tsukada, H.; Hara, E.; Hara, I.; Kizaka-Kondoh, S.; Ohkubo, Y.; Ozeki, E.; et al. Radiosynthesis and Initial Evaluation of ¹⁸F Labeled Nanocarrier Composed of Poly(L-Lactic Acid)-Block-Poly(Sarcosine) Amphiphilic Polydepsipeptide. *Nucl. Med. Biol.* **2013**, *40*, 387–394. [CrossRef] [PubMed]

47. Wang, Q.; Sun, Y.; Zhang, Z.; Duan, Y. Targeted Polymeric Therapeutic Nanoparticles: Design and Interactions with Hepatocellular Carcinoma. *Biomaterials* **2015**, *56*, 229–240. [CrossRef]

48. Kampmann, A.; Luksin, M.; Pretzer, I.; Weberskirch, R. Formation of Well-Defined Polymer Particles in the Sub-100 nm Size Range by Using Amphiphilic Block Copolymer Surfactants and a Microemulsion Approach. *Macromol. Chem. Phys.* **2016**, *217*, 1704–1711. [CrossRef]

49. Berke, S.; Kampmann, A.-L.; Wuest, M.; Bailey, J.J.; Glowacki, B.; Wuest, F.; Jurkschat, K.; Weberskirch, R.; Schirrmacher, R. ¹⁸F-Radiolabeling and In Vivo Analysis of SiFA-Derivatized Polymeric Core–Shell Nanoparticles. *Bioconjug. Chem.* **2018**, *29*, 89–95. [CrossRef]

50. Matson, J.B.; Grubbs, R.H. Synthesis of Fluorine-18 Functionalized Nanoparticles for Use as in Vivo Molecular Imaging Agents. *J. Am. Chem. Soc.* **2008**, *130*, 6731–6733. [CrossRef]

51. Dias, A.P.; Da Silva Santos, S.; Da Silva, J.V.; Parise-Filho, R.; Igne Ferreira, E.; Seoud, O.E.; Giarolla, J. Dendrimers in the Context of Nanomedicine. *Int. J. Pharm.* **2020**, *573*, 118814. [CrossRef] [PubMed]

52. Zhao, L.; Zhu, M.; Li, Y.; Xing, Y.; Zhao, J. Radiolabeled Dendrimers for Nuclear Medicine Applications. *Molecules* **2017**, *22*, 1350. [CrossRef] [PubMed]

53. Trembleau, L.; Simpson, M.; Cheyne, R.W.; Escofet, I.; Appleyard, M.V.C.A.L.; Murray, K.; Sharp, S.; Thompson, A.M.; Smith, T.A.D. Development of ¹⁸F-Fluorinatable Dendrons and Their Application to Cancer Cell Targeting. *N. J. Chem.* **2011**, *35*, 2496. [CrossRef]

54. Zhou, D.; Kim, S.H.; Carroll, V.M.; Dence, C.S.; Katzenellenbogen, J.A. Utilizing Electrostatic Interactions to Facilitate F-18 Radiolabeling of Poly(Amido)Amine (PAMAM) Dendrimers. *Org. Biomol. Chem.* **2014**, *12*, 8696–8701. [CrossRef] [PubMed]

55. Carlson, M.L.; Jackson, I.M.; Azevedo, E.C.; Reyes, S.T.; Alam, I.S.; Kellow, R.; Castillo, J.B.; Nagy, S.C.; Sharma, R.; Brewer, M.; et al. Development and Initial Assessment of [¹⁸F]OP-801: A Novel Hydroxyl Dendrimer PET Tracer for Preclinical Imaging of Innate Immune Activation in the Whole Body and Brain. *Mol. Imaging Biol.* **2023**, *25*, 1063–1072. [CrossRef] [PubMed]

56. Jackson, I.M.; Carlson, M.L.; Beinat, C.; Malik, N.; Kalita, M.; Reyes, S.; Azevedo, E.C.; Nagy, S.C.; Alam, I.S.; Sharma, R.; et al. Clinical Radiosynthesis and Translation of [¹⁸F]OP-801: A Novel Radiotracer for Imaging Reactive Microglia and Macrophages. *ACS Chem. Neurosci.* **2023**, *14*, 2416–2424. [CrossRef] [PubMed]
57. Conte, M.; De Feo, M.S.; Sidrak, M.M.A.; Corica, F.; Gorica, J.; Filippi, L.; Schillaci, O.; De Vincentis, G.; Frantellizzi, V. Radiolabeled Dendrimer Coated Nanoparticles for Radionuclide Imaging and Therapy: A Systematic Review. *Pharmaceutics* **2023**, *15*, 867. [CrossRef] [PubMed]

58. Sun, Y.; Yu, M.; Liang, S.; Zhang, Y.; Li, C.; Mou, T.; Yang, W.; Zhang, X.; Li, B.; Huang, C.; et al. Fluorine-18 Labeled Rare-Earth Nanoparticles for Positron Emission Tomography (PET) Imaging of Sentinel Lymph Node. *Biomaterials* **2011**, *32*, 2999–3007. [CrossRef] [PubMed]

59. Cao, X.; Cao, F.; Xiong, L.; Yang, Y.; Cao, T.; Cai, X.; Hai, W.; Li, B.; Guo, Y.; Zhang, Y.; et al. Cytotoxicity, Tumor Targeting and PET Imaging of Sub-5 nm KGdF₄ Multifunctional Rare Earth Nanoparticles. *Nanoscale* **2015**, *7*, 13404–13409. [CrossRef] [PubMed]

60. Rezende, T.K.L.; Barbosa, H.P.; Dos Santos, L.F.; Lima, K.D.O.; Alves De Matos, P.; Tsubone, T.M.; Gonçalves, R.R.; Ferrari, J.L. Upconversion Rare Earths Nanomaterials Applied to Photodynamic Therapy and Bioimaging. *Front. Chem.* **2022**, *10*, 1035449. [CrossRef]

61. Shi, X.; Gao, K.; Zhang, G.; Zhang, W.; Yang, X.; Gao, R. Signal Amplification Pretargeted PET/Fluorescence Imaging Based on Human Serum Albumin-Encapsulated GdF₃ Nanoparticles for Diagnosis of Ovarian Cancer. *ACS Biomater. Sci. Eng.* **2022**, *8*, 4956–4964. [CrossRef]

62. Xiong, L.; Shen, B.; Behera, D.; Gambhir, S.S.; Chin, F.T.; Rao, J. Synthesis of Ligand-Functionalized Water-Soluble [¹⁸F]YF₃ Nanoparticles for PET Imaging. *Nanoscale* **2013**, *5*, 3253. [CrossRef]

63. Malhotra, K.; Hrovat, D.; Kumar, B.; Qu, G.; Houten, J.V.; Ahmed, R.; Piunno, P.A.E.; Gunning, P.T.; Krull, U.J. Lanthanide-Doped Upconversion Nanoparticles: Exploring A Treasure Trove of NIR-Mediated Emerging Applications. *ACS Appl. Mater. Interfaces* **2023**, *15*, 2499–2528. [CrossRef]

64. Zhong, Y.; Dai, H. A Mini-Review on Rare-Earth down-Conversion Nanoparticles for NIR-II Imaging of Biological Systems. *Nano Res.* **2020**, *13*, 1281–1294. [CrossRef]

65. Wei, Z.; Chao, Z.; Zhang, X.; Yu, J.; Xiao, F.; Zhang, X.; Tian, L. NIR-II Luminescent and Multi-Responsive Rare Earth Nanocrystals for Improved Chemodynamic Therapy. *ACS Appl. Mater. Interfaces* **2023**, *15*, 11575–11585. [CrossRef]

66. Alonso-de Castro, S.; Ruggiero, E.; Lekuona Fernández, A.; Cossío, U.; Baz, Z.; Otaegui, D.; Gómez-Vallejo, V.; Padro, D.; Llop, J.; Salassa, L. Functionalizing NaGdF₄:Yb,Er Upconverting Nanoparticles with Bone-Targeting Phosphonate Ligands: Imaging and In Vivo Biodistribution. *Inorganics* **2019**, *7*, 60. [CrossRef]

67. Goel, S.; England, C.G.; Chen, F.; Cai, W. Positron Emission Tomography and Nanotechnology: A Dynamic Duo for Cancer Theranostics. *Adv. Drug Deliv. Rev.* **2017**, *113*, 157–176. [CrossRef]

68. Goel, S.; Chen, F.; Ehlerding, E.B.; Cai, W. Intrinsically Radiolabeled Nanoparticles: An Emerging Paradigm. *Small* **2014**, *10*, 3825–3830. [CrossRef]

69. Liu, Q.; Sun, Y.; Li, C.; Zhou, J.; Li, C.; Yang, T.; Zhang, X.; Yi, T.; Wu, D.; Li, F. ¹⁸F-Labeled Magnetic-Upconversion Nanophosphors via Rare-Earth Cation-Assisted Ligand Assembly. *ACS Nano* **2011**, *5*, 3146–3157. [CrossRef]

70. Zhou, J.; Yu, M.; Sun, Y.; Zhang, X.; Zhu, X.; Wu, Z.; Wu, D.; Li, F. Fluorine-18-Labeled Gd³⁺/Yb³⁺/Er³⁺ Co-Doped NaYF₄ Nanophosphors for Multimodality PET/MR/UCL Imaging. *Biomaterials* **2011**, *32*, 1148–1156. [CrossRef]

71. Liu, Q.; Chen, M.; Sun, Y.; Chen, G.; Yang, T.; Gao, Y.; Zhang, X.; Li, F. Multifunctional Rare-Earth Self-Assembled Nanosystem for Tri-Modal Upconversion Luminescence/Fluorescence/Positron Emission Tomography Imaging. *Biomaterials* **2011**, *32*, 8243–8253. [CrossRef] [PubMed]

72. Li, Y.; Liu, J.; Qin, X.; Deng, Y.; Zhang, J.; Sun, Y. Ultrafast Synthesis of Fluorine-18 Doped Bismuth Based Upconversion Nanophosphors for Tri-Modal CT/PET/UCL Imaging in Vivo. *Chem. Commun.* **2019**, *55*, 7259–7262. [CrossRef] [PubMed]

73. Tassa, C.; Shaw, S.Y.; Weissleder, R. Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy. *Acc. Chem. Res.* **2011**, *44*, 842–852. [CrossRef] [PubMed]

74. Devaraj, N.K.; Keliher, E.J.; Thurber, G.M.; Nahrendorf, M.; Weissleder, R. ¹⁸F Labeled Nanoparticles for in Vivo PET-CT Imaging. *Bioconjug. Chem.* **2009**, *20*, 397–401. [CrossRef] [PubMed]

75. Nahrendorf, M.; Keliher, E.; Marinelli, B.; Waterman, P.; Feruglio, P.F.; Fexon, L.; Pivovarov, M.; Swirski, F.K.; Pittet, M.J.; Vinegoni, C.; et al. Hybrid PET-Optical Imaging Using Targeted Probes. *Proc. Natl. Acad. Sci. USA* **2010**, *107*, 7910–7915. [CrossRef] [PubMed]

76. Nahrendorf, M.; Keliher, E.; Marinelli, B.; Leuschner, F.; Robbins, C.S.; Gerszten, R.E.; Pittet, M.J.; Swirski, F.K.; Weissleder, R. Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography–Computed Tomography. *Arterioscler. Thromb. Vasc. Biol.* **2011**, *31*, 750–757. [CrossRef] [PubMed]

77. De Simone, M.; Panetta, D.; Bramanti, E.; Giordano, C.; Salvatici, M.C.; Gherardini, L.; Menciassi, A.; Burchielli, S.; Cinti, C.; Salvadori, P.A. Magnetically Driven Nanoparticles: ¹⁸FDG-radiolabelling and Positron Emission Tomography Biodistribution Study. *Contrast Media Mol. Imaging* **2016**, *11*, 561–571. [CrossRef] [PubMed]

78. Wang, Y.; Liu, H.; Yao, D.; Li, J.; Yang, S.; Zhang, C.; Chen, W.; Wang, D. 18F-Labeled Magnetic Nanoparticles for Monitoring Anti-Angiogenic Therapeutic Effects in Breast Cancer Xenografts. *J. Nanobiotechnol.* **2019**, *17*, 105. [CrossRef]

79. Schütz, M.B.; Renner, A.M.; Ilyas, S.; Lê, K.; Guliyev, M.; Krapf, P.; Neumaier, B.; Mathur, S. ¹⁸F-Labeled Magnetic Nanovectors for Bimodal Cellular Imaging. *Biomater. Sci.* **2021**, *9*, 4717–4727. [CrossRef]

80. Sun, Z.; Cheng, K.; Wu, F.; Liu, H.; Ma, X.; Su, X.; Liu, Y.; Xia, L.; Cheng, Z. Robust Surface Coating for a Fast, Facile Fluorine-18 Labeling of Iron Oxide Nanoparticles for PET/MR Dual-Modality Imaging. *Nanoscale* **2016**, *8*, 19644–19653. [CrossRef]
57. Conte, M.; De Feo, M.S.; Sidrak, M.M.A.; Corica, F.; Gorica, J.; Filippi, L.; Schillaci, O.; De Vincentis, G.; Frantellizzi, V. Radiolabeled Dendrimer Coated Nanoparticles for Radionuclide Imaging and Therapy: A Systematic Review. *Pharmaceutics* **2023**, *15*, 867. [CrossRef] [PubMed]

58. Sun, Y.; Yu, M.; Liang, S.; Zhang, Y.; Li, C.; Mou, T.; Yang, W.; Zhang, X.; Li, B.; Huang, C.; et al. Fluorine-18 Labeled Rare-Earth Nanoparticles for Positron Emission Tomography (PET) Imaging of Sentinel Lymph Node. *Biomaterials* **2011**, *32*, 2999–3007. [CrossRef] [PubMed]

59. Cao, X.; Cao, F.; Xiong, L.; Yang, Y.; Cao, T.; Cai, X.; Hai, W.; Li, B.; Guo, Y.; Zhang, Y.; et al. Cytotoxicity, Tumor Targeting and PET Imaging of Sub-5 nm KGdF₄ Multifunctional Rare Earth Nanoparticles. *Nanoscale* **2015**, *7*, 13404–13409. [CrossRef] [PubMed]

60. Rezende, T.K.L.; Barbosa, H.P.; Dos Santos, L.F.; Lima, K.D.O.; Alves De Matos, P.; Tsubone, T.M.; Gonçalves, R.R.; Ferrari, J.L. Upconversion Rare Earths Nanomaterials Applied to Photodynamic Therapy and Bioimaging. *Front. Chem.* **2022**, *10*, 1035449. [CrossRef]

61. Shi, X.; Gao, K.; Zhang, G.; Zhang, W.; Yang, X.; Gao, R. Signal Amplification Pretargeted PET/Fluorescence Imaging Based on Human Serum Albumin-Encapsulated GdF₃ Nanoparticles for Diagnosis of Ovarian Cancer. *ACS Biomater. Sci. Eng.* **2022**, *8*, 4956–4964. [CrossRef]

62. Xiong, L.; Shen, B.; Behera, D.; Gambhir, S.S.; Chin, F.T.; Rao, J. Synthesis of Ligand-Functionalized Water-Soluble [¹⁸F]YF₃ Nanoparticles for PET Imaging. *Nanoscale* **2013**, *5*, 3253. [CrossRef]

63. Malhotra, K.; Hrovat, D.; Kumar, B.; Qu, G.; Houten, J.V.; Ahmed, R.; Piunno, P.A.E.; Gunning, P.T.; Krull, U.J. Lanthanide-Doped Upconversion Nanoparticles: Exploring A Treasure Trove of NIR-Mediated Emerging Applications. *ACS Appl. Mater. Interfaces* **2023**, *15*, 2499–2528. [CrossRef]

64. Zhong, Y.; Dai, H. A Mini-Review on Rare-Earth down-Conversion Nanoparticles for NIR-II Imaging of Biological Systems. *Nano Res.* **2020**, *13*, 1281–1294. [CrossRef]

65. Wei, Z.; Chao, Z.; Zhang, X.; Yu, J.; Xiao, F.; Zhang, X.; Tian, L. NIR-II Luminescent and Multi-Responsive Rare Earth Nanocrystals for Improved Chemodynamic Therapy. *ACS Appl. Mater. Interfaces* **2023**, *15*, 11575–11585. [CrossRef]

66. Alonso-de Castro, S.; Ruggiero, E.; Lekuona Fernández, A.; Cossío, U.; Baz, Z.; Otaegui, D.; Gómez-Vallejo, V.; Padro, D.; Llop, J.; Salassa, L. Functionalizing NaGdF₄:Yb,Er Upconverting Nanoparticles with Bone-Targeting Phosphonate Ligands: Imaging and In Vivo Biodistribution. *Inorganics* **2019**, *7*, 60. [CrossRef]

67. Goel, S.; England, C.G.; Chen, F.; Cai, W. Positron Emission Tomography and Nanotechnology: A Dynamic Duo for Cancer Theranostics. *Adv. Drug Deliv. Rev.* **2017**, *113*, 157–176. [CrossRef]

68. Goel, S.; Chen, F.; Ehlerding, E.B.; Cai, W. Intrinsically Radiolabeled Nanoparticles: An Emerging Paradigm. *Small* **2014**, *10*, 3825–3830. [CrossRef]

69. Liu, Q.; Sun, Y.; Li, C.; Zhou, J.; Li, C.; Yang, T.; Zhang, X.; Yi, T.; Wu, D.; Li, F. ¹⁸F-Labeled Magnetic-Upconversion Nanophosphors via Rare-Earth Cation-Assisted Ligand Assembly. *ACS Nano* **2011**, *5*, 3146–3157. [CrossRef]

70. Zhou, J.; Yu, M.; Sun, Y.; Zhang, X.; Zhu, X.; Wu, Z.; Wu, D.; Li, F. Fluorine-18-Labeled Gd³⁺/Yb³⁺/Er³⁺ Co-Doped NaYF₄ Nanophosphors for Multimodality PET/MR/UCL Imaging. *Biomaterials* **2011**, *32*, 1148–1156. [CrossRef]

71. Liu, Q.; Chen, M.; Sun, Y.; Chen, G.; Yang, T.; Gao, Y.; Zhang, X.; Li, F. Multifunctional Rare-Earth Self-Assembled Nanosystem for Tri-Modal Upconversion Luminescence/Fluorescence/Positron Emission Tomography Imaging. *Biomaterials* **2011**, *32*, 8243–8253. [CrossRef] [PubMed]

72. Li, Y.; Liu, J.; Qin, X.; Deng, Y.; Zhang, J.; Sun, Y. Ultrafast Synthesis of Fluorine-18 Doped Bismuth Based Upconversion Nanophosphors for Tri-Modal CT/PET/UCL Imaging in Vivo. *Chem. Commun.* **2019**, *55*, 7259–7262. [CrossRef] [PubMed]

73. Tassa, C.; Shaw, S.Y.; Weissleder, R. Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy. *Acc. Chem. Res.* **2011**, *44*, 842–852. [CrossRef] [PubMed]

74. Devaraj, N.K.; Keliher, E.J.; Thurber, G.M.; Nahrendorf, M.; Weissleder, R. ¹⁸F Labeled Nanoparticles for in Vivo PET-CT Imaging. *Bioconjug. Chem.* **2009**, *20*, 397–401. [CrossRef] [PubMed]

75. Nahrendorf, M.; Keliher, E.; Marinelli, B.; Waterman, P.; Feruglio, P.F.; Fexon, L.; Pivovarov, M.; Swirski, F.K.; Pittet, M.J.; Vinegoni, C.; et al. Hybrid PET-Optical Imaging Using Targeted Probes. *Proc. Natl. Acad. Sci. USA* **2010**, *107*, 7910–7915. [CrossRef] [PubMed]

76. Nahrendorf, M.; Keliher, E.; Marinelli, B.; Leuschner, F.; Robbins, C.S.; Gerszten, R.E.; Pittet, M.J.; Swirski, F.K.; Weissleder, R. Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography–Computed Tomography. *Arterioscler. Thromb. Vasc. Biol.* **2011**, *31*, 750–757. [CrossRef] [PubMed]

77. De Simone, M.; Panetta, D.; Bramanti, E.; Giordano, C.; Salvatici, M.C.; Gherardini, L.; Menciassi, A.; Burchielli, S.; Cinti, C.; Salvadori, P.A. Magnetically Driven Nanoparticles: ¹⁸FDG-radiolabelling and Positron Emission Tomography Biodistribution Study. *Contrast Media Mol. Imaging* **2016**, *11*, 561–571. [CrossRef] [PubMed]

78. Wang, Y.; Liu, H.; Yao, D.; Li, J.; Yang, S.; Zhang, C.; Chen, W.; Wang, D. 18F-Labeled Magnetic Nanoparticles for Monitoring Anti-Angiogenic Therapeutic Effects in Breast Cancer Xenografts. *J. Nanobiotechnol.* **2019**, *17*, 105. [CrossRef]

79. Schütz, M.B.; Renner, A.M.; Ilyas, S.; Lê, K.; Guliyev, M.; Krapf, P.; Neumaier, B.; Mathur, S. ¹⁸F-Labeled Magnetic Nanovectors for Bimodal Cellular Imaging. *Biomater. Sci.* **2021**, *9*, 4717–4727. [CrossRef]

80. Sun, Z.; Cheng, K.; Wu, F.; Liu, H.; Ma, X.; Su, X.; Liu, Y.; Xia, L.; Cheng, Z. Robust Surface Coating for a Fast, Facile Fluorine-18 Labeling of Iron Oxide Nanoparticles for PET/MR Dual-Modality Imaging. *Nanoscale* **2016**, *8*, 19644–19653. [CrossRef]
81. Cui, X. Aluminium Hydroxide Stabilised MnFe₂O₄ and Fe₃O₄ Nanoparticles as Dual-Modality Contrasts Agent for MRI and PET Imaging. *Biomaterials* **2014**, *35*, 5840–5846. [CrossRef] [PubMed]

82. González-Gómez, M.A.; Belderbos, S.; Yañez-Vilar, S.; Piñeiro, Y.; Cleeren, F.; Bormans, G.; Deroose, C.M.; Gsell, W.; Himmelreich, U.; Rivas, J. Development of Superparamagnetic Nanoparticles Coated with Polyacrylic Acid and Aluminum Hydroxide as an Efficient Contrast Agent for Multimodal Imaging. *Nanomaterials* **2019**, *9*, 1626. [CrossRef] [PubMed]

83. Belderbos, S.; González-Gómez, M.A.; Cleeren, F.; Wouters, J.; Piñeiro, Y.; Deroose, C.M.; Coosemans, A.; Gsell, W.; Bormans, G.; Rivas, J.; et al. Simultaneous in Vivo PET/MRI Using Fluorine-18 Labeled Fe₃O₄@Al(OH)₃ Nanoparticles: Comparison of Nanoparticle and Nanoparticle-Labeled Stem Cell Distribution. *EJNMMI Res.* **2020**, *10*, 73. [CrossRef] [PubMed]

84. Cui, X.; Mathe, D.; Kovács, N.; Horváth, I.; Jauregui-Osoro, M.; Torres Martín De Rosales, R.; Mullen, G.E.D.; Wong, W.; Yan, Y.; Krüger, D.; et al. Synthesis, Characterization, and Application of Core-Shell Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm) Nanoparticle as Trimodal (MRI, PET/SPECT, and Optical) Imaging Agents. *Bioconjug. Chem.* **2016**, *27*, 319–328. [CrossRef] [PubMed]

85. Pérez-Campaña, C.; Sansaloni, F.; Gómez-Vallejo, V.; Baz, Z.; Martin, A.; Moya, S.E.; Lagares, J.I.; Ziolo, R.F.; Llop, J. Production of ¹⁸F-Labeled Titanium Dioxide Nanoparticles by Proton Irradiation for Biodistribution and Biological Fate Studies in Rats. *Part. Part. Syst. Charact.* **2014**, *31*, 134–142. [CrossRef]

86. Wang, J.; Wang, Z.; Wang, W.; Wang, Y.; Hu, X.; Liu, J.; Gong, X.; Miao, W.; Ding, L.; Li, X.; et al. Synthesis, Modification and Application of Titanium Dioxide Nanoparticles: A Review. *Nanoscale* **2022**, *14*, 6709–6734. [CrossRef] [PubMed]

87. Ziental, D.; Czarczynska-Goslinska, B.; Mlynarczyk, D.T.; Glowacka-Sobotta, A.; Stanisz, B.; Goslinski, T.; Sobotta, L. Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine. *Nanomaterials* **2020**, *10*, 387. [CrossRef] [PubMed]

88. Lee, C.-M.; Jeong, H.-J.; Kim, D.W.; Sohn, M.-H.; Lim, S.T. The Effect of Fluorination of Zinc Oxide Nanoparticles on Evaluation of Their Biodistribution after Oral Administration. *Nanotechnology* **2012**, *23*, 205102. [CrossRef] [PubMed]

89. Rojas, S.; Gispert, J.D.; Abad, S.; Buaki-Sogo, M.; Victor, V.M.; Garcia, H.; Herance, J.R. In Vivo Biodistribution of Amino-Functionalized Ceria Nanoparticles in Rats Using Positron Emission Tomography. *Mol. Pharm.* **2012**, *9*, 3543–3550. [CrossRef] [PubMed]

90. Pérez-Campaña, C.; Gómez-Vallejo, V.; Martin, A.; San Sebastián, E.; Moya, S.E.; Reese, T.; Ziolo, R.F.; Llop, J. Tracing Nanoparticles in Vivo: A New General Synthesis of Positron Emitting Metal Oxide Nanoparticles by Proton Beam Activation. *Analyst* **2012**, *137*, 4902. [CrossRef]

91. Pérez-Campaña, C.; Gómez-Vallejo, V.; Puigivila, M.; Martín, A.; Calvo-Fernández, T.; Moya, S.E.; Ziolo, R.F.; Reese, T.; Llop, J. Biodistribution of Different Sized Nanoparticles Assessed by Positron Emission Tomography: A General Strategy for Direct Activation of Metal Oxide Particles. *ACS Nano* **2013**, *7*, 3498–3505. [CrossRef]

92. Jauregui-Osoro, M.; Williamson, P.A.; Glaria, A.; Sunassee, K.; Charoenphun, P.; Green, M.A.; Mullen, G.E.D.; Blower, P.J. Biocompatible Inorganic Nanoparticles for [¹⁸F]-Fluoride Binding with Applications in PET Imaging. *Dalton Trans.* **2011**, *40*, 6226. [CrossRef]

93. Cui, X.; Green, M.A.; Blower, P.J.; Zhou, D.; Yan, Y.; Zhang, W.; Djanashvili, K.; Mathe, D.; Veres, D.S.; Szigeti, K. Al(OH)₃ Facilitated Synthesis of Water-Soluble, Magnetic, Radiolabelled and Fluorescent Hydroxyapatite Nanoparticles. *Chem. Commun.* **2015**, *51*, 9332–9335. [CrossRef]

94. Sahu, A.; Kumar, D. Core-Shell Quantum Dots: A Review on Classification, Materials, Application, and Theoretical Modeling. *J. Alloys Compd.* **2022**, *924*, 166508. [CrossRef]

95. Wegner, K.D.; Hildebrandt, N. Quantum Dots: Bright and Versatile in Vitro and in Vivo Fluorescence Imaging Biosensors. *Chem. Soc. Rev.* **2015**, *44*, 4792–4834. [CrossRef]

96. Abdellatif, A.A.; Younis, M.A.; Alsharidah, M.; Al Rugaie, O.; Tawfeek, H.M. Biomedical Applications of Quantum Dots: Overview, Challenges, and Clinical Potential. *Int. J. Nanomed.* **2022**, *17*, 1951–1970. [CrossRef] [PubMed]

97. Hu, K.; Wang, H.; Tang, G.; Huang, T.; Tang, X.; Liang, X.; Yao, S.; Nie, D. In Vivo Cancer Dual-Targeting and Dual-Modality Imaging with Functionalized Quantum Dots. *J. Nucl. Med.* **2015**, *56*, 1278–1284. [CrossRef] [PubMed]

98. Patt, M.; Schildan, A.; Habermann, B.; Mishchenko, O.; Patt, J.T.; Sabri, O. ¹⁸F- and ¹¹C-Labelling of Quantum Dots with n.c.a. [¹⁸F]Fluoroethyltosylate and [¹¹C]Methyliodide: A Feasibility Study. *J. Radioanal. Nucl. Chem.* **2010**, *283*, 487–491. [CrossRef]

99. Kus-Liśkiewicz, M.; Fickers, P.; Ben Tahar, I. Biocompatibility and Cytotoxicity of Gold Nanoparticles: Recent Advances in Methodologies and Regulations. *Int. J. Mol. Sci.* **2021**, *22*, 10952. [CrossRef]

100. Ielo, I.; Rando, G.; Giacobello, F.; Sfameni, S.; Castellano, A.; Galletta, M.; Drommi, D.; Rosace, G.; Plutino, M.R. Synthesis, Chemical-Physical Characterization, and Biomedical Applications of Functional Gold Nanoparticles: A Review. *Molecules* **2021**, *26*, 5823. [CrossRef]

101. Okyem, S.; Awotunde, O.; Ogunlusi, T.; Riley, M.B.; Driskell, J.D. High-Affinity Points of Interaction on Antibody Allow Synthesis of Stable and Highly Functional Antibody-Gold Nanoparticle Conjugates. *Bioconjug. Chem.* **2021**, *32*, 1753–1762. [CrossRef]

102. Tan, K.F.; In, L.L.A.; Vijayaraj Kumar, P. Surface Functionalization of Gold Nanoparticles for Targeting the Tumor Microenvironment to Improve Antitumor Efficiency. *ACS Appl. Bio Mater.* **2023**, *6*, 2944–2981. [CrossRef] [PubMed]

103. Xi, Z.; Zhang, R.; Kiessling, F.; Lammers, T.; Pallares, R.M. Role of Surface Curvature in Gold Nanostar Properties and Applications. *ACS Biomater. Sci. Eng.* **2024**, *10*, 38–50. [CrossRef] [PubMed]

104. Chen, Y.; Yang, J.; Fu, S.; Wu, J. Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy. *Int. J. Nanomed.* **2020**, *15*, 9407–9430. [CrossRef] [PubMed]
81. Cui, X. Aluminium Hydroxide Stabilised MnFe₂O₄ and Fe₃O₄ Nanoparticles as Dual-Modality Contrasts Agent for MRI and PET Imaging. *Biomaterials* **2014**, *35*, 5840–5846. [CrossRef] [PubMed]

82. González-Gómez, M.A.; Belderbos, S.; Yañez-Vilar, S.; Piñeiro, Y.; Cleeren, F.; Bormans, G.; Deroose, C.M.; Gsell, W.; Himmelreich, U.; Rivas, J. Development of Superparamagnetic Nanoparticles Coated with Polyacrylic Acid and Aluminum Hydroxide as an Efficient Contrast Agent for Multimodal Imaging. *Nanomaterials* **2019**, *9*, 1626. [CrossRef] [PubMed]

83. Belderbos, S.; González-Gómez, M.A.; Cleeren, F.; Wouters, J.; Piñeiro, Y.; Deroose, C.M.; Coosemans, A.; Gsell, W.; Bormans, G.; Rivas, J.; et al. Simultaneous in Vivo PET/MRI Using Fluorine-18 Labeled Fe₃O₄@Al(OH)₃ Nanoparticles: Comparison of Nanoparticle and Nanoparticle-Labeled Stem Cell Distribution. *EJNMMI Res.* **2020**, *10*, 73. [CrossRef] [PubMed]

84. Cui, X.; Mathe, D.; Kovács, N.; Horváth, I.; Jauregui-Osoro, M.; Torres Martín De Rosales, R.; Mullen, G.E.D.; Wong, W.; Yan, Y.; Krüger, D.; et al. Synthesis, Characterization, and Application of Core-Shell Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm) Nanoparticle as Trimodal (MRI, PET/SPECT, and Optical) Imaging Agents. *Bioconjug. Chem.* **2016**, *27*, 319–328. [CrossRef] [PubMed]

85. Pérez-Campaña, C.; Sansaloni, F.; Gómez-Vallejo, V.; Baz, Z.; Martin, A.; Moya, S.E.; Lagares, J.I.; Ziolo, R.F.; Llop, J. Production of ¹⁸F-Labeled Titanium Dioxide Nanoparticles by Proton Irradiation for Biodistribution and Biological Fate Studies in Rats. *Part. Part. Syst. Charact.* **2014**, *31*, 134–142. [CrossRef]

86. Wang, J.; Wang, Z.; Wang, W.; Wang, Y.; Hu, X.; Liu, J.; Gong, X.; Miao, W.; Ding, L.; Li, X.; et al. Synthesis, Modification and Application of Titanium Dioxide Nanoparticles: A Review. *Nanoscale* **2022**, *14*, 6709–6734. [CrossRef] [PubMed]

87. Ziental, D.; Czarczynska-Goslinska, B.; Mlynarczyk, D.T.; Glowacka-Sobotta, A.; Stanisz, B.; Goslinski, T.; Sobotta, L. Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine. *Nanomaterials* **2020**, *10*, 387. [CrossRef] [PubMed]

88. Lee, C.-M.; Jeong, H.-J.; Kim, D.W.; Sohn, M.-H.; Lim, S.T. The Effect of Fluorination of Zinc Oxide Nanoparticles on Evaluation of Their Biodistribution after Oral Administration. *Nanotechnology* **2012**, *23*, 205102. [CrossRef] [PubMed]

89. Rojas, S.; Gispert, J.D.; Abad, S.; Buaki-Sogo, M.; Victor, V.M.; Garcia, H.; Herance, J.R. In Vivo Biodistribution of Amino-Functionalized Ceria Nanoparticles in Rats Using Positron Emission Tomography. *Mol. Pharm.* **2012**, *9*, 3543–3550. [CrossRef] [PubMed]

90. Pérez-Campaña, C.; Gómez-Vallejo, V.; Martin, A.; San Sebastián, E.; Moya, S.E.; Reese, T.; Ziolo, R.F.; Llop, J. Tracing Nanoparticles in Vivo: A New General Synthesis of Positron Emitting Metal Oxide Nanoparticles by Proton Beam Activation. *Analyst* **2012**, *137*, 4902. [CrossRef]

91. Pérez-Campaña, C.; Gómez-Vallejo, V.; Puigivila, M.; Martín, A.; Calvo-Fernández, T.; Moya, S.E.; Ziolo, R.F.; Reese, T.; Llop, J. Biodistribution of Different Sized Nanoparticles Assessed by Positron Emission Tomography: A General Strategy for Direct Activation of Metal Oxide Particles. *ACS Nano* **2013**, *7*, 3498–3505. [CrossRef]

92. Jauregui-Osoro, M.; Williamson, P.A.; Glaria, A.; Sunassee, K.; Charoenphun, P.; Green, M.A.; Mullen, G.E.D.; Blower, P.J. Biocompatible Inorganic Nanoparticles for [¹⁸F]-Fluoride Binding with Applications in PET Imaging. *Dalton Trans.* **2011**, *40*, 6226. [CrossRef]

93. Cui, X.; Green, M.A.; Blower, P.J.; Zhou, D.; Yan, Y.; Zhang, W.; Djanashvili, K.; Mathe, D.; Veres, D.S.; Szigeti, K. Al(OH)₃ Facilitated Synthesis of Water-Soluble, Magnetic, Radiolabelled and Fluorescent Hydroxyapatite Nanoparticles. *Chem. Commun.* **2015**, *51*, 9332–9335. [CrossRef]

94. Sahu, A.; Kumar, D. Core-Shell Quantum Dots: A Review on Classification, Materials, Application, and Theoretical Modeling. *J. Alloys Compd.* **2022**, *924*, 166508. [CrossRef]

95. Wegner, K.D.; Hildebrandt, N. Quantum Dots: Bright and Versatile in Vitro and in Vivo Fluorescence Imaging Biosensors. *Chem. Soc. Rev.* **2015**, *44*, 4792–4834. [CrossRef]

96. Abdellatif, A.A.; Younis, M.A.; Alsharidah, M.; Al Rugaie, O.; Tawfeek, H.M. Biomedical Applications of Quantum Dots: Overview, Challenges, and Clinical Potential. *Int. J. Nanomed.* **2022**, *17*, 1951–1970. [CrossRef] [PubMed]

97. Hu, K.; Wang, H.; Tang, G.; Huang, T.; Tang, X.; Liang, X.; Yao, S.; Nie, D. In Vivo Cancer Dual-Targeting and Dual-Modality Imaging with Functionalized Quantum Dots. *J. Nucl. Med.* **2015**, *56*, 1278–1284. [CrossRef] [PubMed]

98. Patt, M.; Schildan, A.; Habermann, B.; Mishchenko, O.; Patt, J.T.; Sabri, O. ¹⁸F- and ¹¹C-Labelling of Quantum Dots with n.c.a. [¹⁸F]Fluoroethyltosylate and [¹¹C]Methyliodide: A Feasibility Study. *J. Radioanal. Nucl. Chem.* **2010**, *283*, 487–491. [CrossRef]

99. Kus-Liśkiewicz, M.; Fickers, P.; Ben Tahar, I. Biocompatibility and Cytotoxicity of Gold Nanoparticles: Recent Advances in Methodologies and Regulations. *Int. J. Mol. Sci.* **2021**, *22*, 10952. [CrossRef]

100. Ielo, I.; Rando, G.; Giacobello, F.; Sfameni, S.; Castellano, A.; Galletta, M.; Drommi, D.; Rosace, G.; Plutino, M.R. Synthesis, Chemical-Physical Characterization, and Biomedical Applications of Functional Gold Nanoparticles: A Review. *Molecules* **2021**, *26*, 5823. [CrossRef]

101. Okyem, S.; Awotunde, O.; Ogunlusi, T.; Riley, M.B.; Driskell, J.D. High-Affinity Points of Interaction on Antibody Allow Synthesis of Stable and Highly Functional Antibody-Gold Nanoparticle Conjugates. *Bioconjug. Chem.* **2021**, *32*, 1753–1762. [CrossRef]

102. Tan, K.F.; In, L.L.A.; Vijayaraj Kumar, P. Surface Functionalization of Gold Nanoparticles for Targeting the Tumor Microenvironment to Improve Antitumor Efficiency. *ACS Appl. Bio Mater.* **2023**, *6*, 2944–2981. [CrossRef] [PubMed]

103. Xi, Z.; Zhang, R.; Kiessling, F.; Lammers, T.; Pallares, R.M. Role of Surface Curvature in Gold Nanostar Properties and Applications. *ACS Biomater. Sci. Eng.* **2024**, *10*, 38–50. [CrossRef] [PubMed]

104. Chen, Y.; Yang, J.; Fu, S.; Wu, J. Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy. *Int. J. Nanomed.* **2020**, *15*, 9407–9430. [CrossRef] [PubMed]
105. Das, P.; Fatehbasharzad, P.; Colombo, M.; Fiandra, L.; Prosperi, D. Multifunctional Magnetic Gold Nanomaterials for Cancer. *Trends Biotechnol.* **2019**, *37*, 995–1010. [CrossRef] [PubMed]

106. Cho, H.H.; Jung, D.H.; Heo, J.H.; Lee, C.Y.; Jeong, S.Y.; Lee, J.H. Gold Nanoparticles as Exquisite Colorimetric Transducers for Water Pollutant Detection. *ACS Appl. Mater. Interfaces* **2023**, *15*, 19785–19806. [CrossRef]

107. Bouché, M.; Hsu, J.C.; Dong, Y.C.; Kim, J.; Taing, K.; Cormode, D.P. Recent Advances in Molecular Imaging with Gold Nanoparticles. *Bioconjug. Chem.* **2020**, *31*, 303–314. [CrossRef] [PubMed]

108. Luo, D.; Wang, X.; Burda, C.; Basilion, J.P. Recent Development of Gold Nanoparticles as Contrast Agents for Cancer Diagnosis. *Cancers* **2021**, *13*, 1825. [CrossRef]

109. Yang, Z.; Yang, X.; Guo, Y.; Kawasaki, H. A Review on Gold Nanoclusters for Cancer Phototherapy. *ACS Appl. Bio Mater.* **2023**, *6*, 4504–4517. [CrossRef]

110. Ge, P.; Zhang, J.; Ding, T.; Xianyu, Y. Surface Chemistry of Gold Nanoparticles for Bacterial Detection and Antimicrobial Applications. *ACS Mater. Lett.* **2023**, *5*, 638–655. [CrossRef]

111. Zhao, X.; Tang, H.; Jiang, X. Deploying Gold Nanomaterials in Combating Multi-Drug-Resistant Bacteria. *ACS Nano* **2022**, *16*, 10066–10087. [CrossRef] [PubMed]

112. Mantri, Y.; Jokerst, J.V. Engineering Plasmonic Nanoparticles for Enhanced Photoacoustic Imaging. *ACS Nano* **2020**, *14*, 9408–9422. [CrossRef]

113. Roa, W.; Xiong, Y.; Chen, J.; Yang, X.; Song, K.; Yang, X.; Kong, B.; Wilson, J.; Xing, J.Z. Pharmacokinetic and Toxicological Evaluation of Multi-Functional Thiol-6-Fluoro-6-Deoxy-d-Glucose Gold Nanoparticles in vivo. *Nanotechnology* **2012**, *23*, 375101. [CrossRef] [PubMed]

114. van de Looij, S.M.; Hebels, E.R.; Viola, M.; Hembury, M.; Oliveira, S.; Vermonden, T. Gold Nanoclusters: Imaging, Therapy, and Theranostic Roles in Biomedical Applications. *Bioconjug. Chem.* **2022**, *33*, 4–23. [CrossRef] [PubMed]

115. Fan, M.; Han, Y.; Gao, S.; Yan, H.; Cao, L.; Li, Z.; Liang, X.-J.; Zhang, J. Ultrasmall Gold Nanoparticles in Cancer Diagnosis and Therapy. *Theranostics* **2020**, *10*, 4944–4957. [CrossRef] [PubMed]

116. Yañez-Aulestia, A.; Gupta, N.K.; Hernández, M.; Osorio-Toribio, G.; Sánchez-González, E.; Guzmán-Vargas, A.; Rivera, J.L.; Ibarra, I.A.; Lima, E. Gold Nanoparticles: Current and Upcoming Biomedical Applications in Sensing, Drug, and Gene Delivery. *Chem. Commun.* **2022**, *58*, 10886–10895. [CrossRef]

117. Jahangiri-Manesh, A.; Mousazadeh, M.; Taji, S.; Bahmani, A.; Zarepour, A.; Zarrabi, A.; Sharifi, E.; Azimzadeh, M. Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements. *Pharmaceutics* **2022**, *14*, 664. [CrossRef] [PubMed]

118. Pissuwan, D.; Poomrattanangoon, S.; Chungchaiyart, P. Trends in Using Gold Nanoparticles for Inducing Cell Differentiation: A Review. *ACS Appl. Nano Mater.* **2022**, *5*, 3110–3120. [CrossRef]

119. Kimling, J.; Maier, M.; Okenve, B.; Kotaidis, V.; Ballot, H.; Plech, A. Turkevich Method for Gold Nanoparticle Synthesis Revisited. *J. Phys. Chem. B* **2006**, *110*, 15700–15707. [CrossRef]

120. Guerrero, S.; Herance, J.R.; Rojas, S.; Mena, J.F.; Gispert, J.D.; Acosta, G.A.; Albericio, F.; Kogan, M.J. Synthesis and In Vivo Evaluation of the Biodistribution of a ¹⁸F-Labeled Conjugate Gold-Nanoparticle-Peptide with Potential Biomedical Application. *Bioconjug. Chem.* **2012**, *23*, 399–408. [CrossRef]

121. Zhu, J.; Waengler, C.; Lennox, R.B.; Schirrmacher, R. Preparation of Water-Soluble Maleimide-Functionalized 3 nm Gold Nanoparticles: A New Bioconjugation Template. *Langmuir* **2012**, *28*, 5508–5512. [CrossRef] [PubMed]

122. Zhu, J.; Chin, J.; Wängler, C.; Wängler, B.; Lennox, R.B.; Schirrmacher, R. Rapid ¹⁸F-Labeling and Loading of PEGylated Gold Nanoparticles for in Vivo Applications. *Bioconjug. Chem.* **2014**, *25*, 1143–1150. [CrossRef] [PubMed]

123. De Paz, J.-L.; Ojeda, R.; Barrientos, Á.G.; Penadés, S.; Martín-Lomas, M. Synthesis of a Ley Neoglycoconjugate and Ley-Functionalized Gold Glyconanoparticles. *Tetrahedron Asymmetry* **2005**, *16*, 149–158. [CrossRef]

124. Ghiassian, S.; Yu, L.; Gobbo, P.; Nazemi, A.; Romagnoli, T.; Luo, W.; Luyt, L.G.; Workentin, M.S. Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as ¹⁸F-Labeled Positron Emission Tomography Probes via I-SPANC. *ACS Omega* **2019**, *4*, 19106–19115. [CrossRef] [PubMed]

125. Yang, H.; Zhang, L.; Liu, H.; Zhang, Y.; Mou, Z.; Chen, X.; Li, J.; He, F.; Li, Z. Simplified One-Pot ¹⁸F-Labeling of Biomolecules with in Situ Generated Fluorothiophosphate Synthons in High Molar Activity. *Theranostics* **2023**, *13*, 472–482. [CrossRef]

126. Hosseini, S.M.; Mohammadnejad, J.; Najafi-Taher, R.; Zadeh, Z.B.; Tanhaei, M.; Ramakrishna, S. Multifunctional Carbon-Based Nanoparticles: Theranostic Applications in Cancer Therapy and Diagnosis. *ACS Appl. Bio Mater.* **2023**, *6*, 1323–1338. [CrossRef] [PubMed]

127. Jaymand, M.; Davatgaran Taghipour, Y.; Rezaei, A.; Derakhshankhah, H.; Foad Abazari, M.; Samadian, H.; Hamblin, M.R. Radiolabeled Carbon-Based Nanostructures: New Radiopharmaceuticals for Cancer Therapy? *Coord. Chem. Rev.* **2021**, *440*, 213974. [CrossRef]

128. Krueger, A.; Lang, D. Functionality Is Key: Recent Progress in the Surface Modification of Nanodiamond. *Adv. Funct. Mater.* **2012**, *22*, 890–906. [CrossRef]

129. Tegafaw, T.; Liu, S.; Ahmad, M.Y.; Ali Al Saidi, A.K.; Zhao, D.; Liu, Y.; Yue, H.; Nam, S.-W.; Chang, Y.; Lee, G.H. Production, Surface Modification, Physicochemical Properties, Biocompatibility, and Bioimaging Applications of Nanodiamonds. *RSC Adv.* **2023**, *13*, 32381–32397. [CrossRef]
105. Das, P.; Fatehbasharzad, P.; Colombo, M.; Fiandra, L.; Prosperi, D. Multifunctional Magnetic Gold Nanomaterials for Cancer. *Trends Biotechnol.* **2019**, *37*, 995–1010. [CrossRef] [PubMed]

106. Cho, H.H.; Jung, D.H.; Heo, J.H.; Lee, C.Y.; Jeong, S.Y.; Lee, J.H. Gold Nanoparticles as Exquisite Colorimetric Transducers for Water Pollutant Detection. *ACS Appl. Mater. Interfaces* **2023**, *15*, 19785–19806. [CrossRef]

107. Bouché, M.; Hsu, J.C.; Dong, Y.C.; Kim, J.; Taing, K.; Cormode, D.P. Recent Advances in Molecular Imaging with Gold Nanoparticles. *Bioconjug. Chem.* **2020**, *31*, 303–314. [CrossRef] [PubMed]

108. Luo, D.; Wang, X.; Burda, C.; Basilion, J.P. Recent Development of Gold Nanoparticles as Contrast Agents for Cancer Diagnosis. *Cancers* **2021**, *13*, 1825. [CrossRef]

109. Yang, Z.; Yang, X.; Guo, Y.; Kawasaki, H. A Review on Gold Nanoclusters for Cancer Phototherapy. *ACS Appl. Bio Mater.* **2023**, *6*, 4504–4517. [CrossRef]

110. Ge, P.; Zhang, J.; Ding, T.; Xianyu, Y. Surface Chemistry of Gold Nanoparticles for Bacterial Detection and Antimicrobial Applications. *ACS Mater. Lett.* **2023**, *5*, 638–655. [CrossRef]

111. Zhao, X.; Tang, H.; Jiang, X. Deploying Gold Nanomaterials in Combating Multi-Drug-Resistant Bacteria. *ACS Nano* **2022**, *16*, 10066–10087. [CrossRef] [PubMed]

112. Mantri, Y.; Jokerst, J.V. Engineering Plasmonic Nanoparticles for Enhanced Photoacoustic Imaging. *ACS Nano* **2020**, *14*, 9408–9422. [CrossRef]

113. Roa, W.; Xiong, Y.; Chen, J.; Yang, X.; Song, K.; Yang, X.; Kong, B.; Wilson, J.; Xing, J.Z. Pharmacokinetic and Toxicological Evaluation of Multi-Functional Thiol-6-Fluoro-6-Deoxy-d-Glucose Gold Nanoparticles in vivo. *Nanotechnology* **2012**, *23*, 375101. [CrossRef] [PubMed]

114. van de Looij, S.M.; Hebels, E.R.; Viola, M.; Hembury, M.; Oliveira, S.; Vermonden, T. Gold Nanoclusters: Imaging, Therapy, and Theranostic Roles in Biomedical Applications. *Bioconjug. Chem.* **2022**, *33*, 4–23. [CrossRef] [PubMed]

115. Fan, M.; Han, Y.; Gao, S.; Yan, H.; Cao, L.; Li, Z.; Liang, X.-J.; Zhang, J. Ultrasmall Gold Nanoparticles in Cancer Diagnosis and Therapy. *Theranostics* **2020**, *10*, 4944–4957. [CrossRef] [PubMed]

116. Yañez-Aulestia, A.; Gupta, N.K.; Hernández, M.; Osorio-Toribio, G.; Sánchez-González, E.; Guzmán-Vargas, A.; Rivera, J.L.; Ibarra, I.A.; Lima, E. Gold Nanoparticles: Current and Upcoming Biomedical Applications in Sensing, Drug, and Gene Delivery. *Chem. Commun.* **2022**, *58*, 10886–10895. [CrossRef]

117. Jahangiri-Manesh, A.; Mousazadeh, M.; Taji, S.; Bahmani, A.; Zarepour, A.; Zarrabi, A.; Sharifi, E.; Azimzadeh, M. Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements. *Pharmaceutics* **2022**, *14*, 664. [CrossRef] [PubMed]

118. Pissuwan, D.; Poomrattanangoon, S.; Chungchaiyart, P. Trends in Using Gold Nanoparticles for Inducing Cell Differentiation: A Review. *ACS Appl. Nano Mater.* **2022**, *5*, 3110–3120. [CrossRef]

119. Kimling, J.; Maier, M.; Okenve, B.; Kotaidis, V.; Ballot, H.; Plech, A. Turkevich Method for Gold Nanoparticle Synthesis Revisited. *J. Phys. Chem. B* **2006**, *110*, 15700–15707. [CrossRef]

120. Guerrero, S.; Herance, J.R.; Rojas, S.; Mena, J.F.; Gispert, J.D.; Acosta, G.A.; Albericio, F.; Kogan, M.J. Synthesis and In Vivo Evaluation of the Biodistribution of a ¹⁸F-Labeled Conjugate Gold-Nanoparticle-Peptide with Potential Biomedical Application. *Bioconjug. Chem.* **2012**, *23*, 399–408. [CrossRef]

121. Zhu, J.; Waengler, C.; Lennox, R.B.; Schirrmacher, R. Preparation of Water-Soluble Maleimide-Functionalized 3 nm Gold Nanoparticles: A New Bioconjugation Template. *Langmuir* **2012**, *28*, 5508–5512. [CrossRef] [PubMed]

122. Zhu, J.; Chin, J.; Wängler, C.; Wängler, B.; Lennox, R.B.; Schirrmacher, R. Rapid ¹⁸F-Labeling and Loading of PEGylated Gold Nanoparticles for in Vivo Applications. *Bioconjug. Chem.* **2014**, *25*, 1143–1150. [CrossRef] [PubMed]

123. De Paz, J.-L.; Ojeda, R.; Barrientos, Á.G.; Penadés, S.; Martín-Lomas, M. Synthesis of a Ley Neoglycoconjugate and Ley-Functionalized Gold Glyconanoparticles. *Tetrahedron Asymmetry* **2005**, *16*, 149–158. [CrossRef]

124. Ghiassian, S.; Yu, L.; Gobbo, P.; Nazemi, A.; Romagnoli, T.; Luo, W.; Luyt, L.G.; Workentin, M.S. Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as ¹⁸F-Labeled Positron Emission Tomography Probes via I-SPANC. *ACS Omega* **2019**, *4*, 19106–19115. [CrossRef] [PubMed]

125. Yang, H.; Zhang, L.; Liu, H.; Zhang, Y.; Mou, Z.; Chen, X.; Li, J.; He, F.; Li, Z. Simplified One-Pot ¹⁸F-Labeling of Biomolecules with in Situ Generated Fluorothiophosphate Synthons in High Molar Activity. *Theranostics* **2023**, *13*, 472–482. [CrossRef]

126. Hosseini, S.M.; Mohammadnejad, J.; Najafi-Taher, R.; Zadeh, Z.B.; Tanhaei, M.; Ramakrishna, S. Multifunctional Carbon-Based Nanoparticles: Theranostic Applications in Cancer Therapy and Diagnosis. *ACS Appl. Bio Mater.* **2023**, *6*, 1323–1338. [CrossRef] [PubMed]

127. Jaymand, M.; Davatgaran Taghipour, Y.; Rezaei, A.; Derakhshankhah, H.; Foad Abazari, M.; Samadian, H.; Hamblin, M.R. Radiolabeled Carbon-Based Nanostructures: New Radiopharmaceuticals for Cancer Therapy? *Coord. Chem. Rev.* **2021**, *440*, 213974. [CrossRef]

128. Krueger, A.; Lang, D. Functionality Is Key: Recent Progress in the Surface Modification of Nanodiamond. *Adv. Funct. Mater.* **2012**, *22*, 890–906. [CrossRef]

129. Tegafaw, T.; Liu, S.; Ahmad, M.Y.; Ali Al Saidi, A.K.; Zhao, D.; Liu, Y.; Yue, H.; Nam, S.-W.; Chang, Y.; Lee, G.H. Production, Surface Modification, Physicochemical Properties, Biocompatibility, and Bioimaging Applications of Nanodiamonds. *RSC Adv.* **2023**, *13*, 32381–32397. [CrossRef]
130. Rojas, S.; Gispert, J.D.; Martín, R.; Abad, S.; Menchón, C.; Pareto, D.; Víctor, V.M.; Álvaro, M.; García, H.; Herance, J.R. Biodistribution of Amino-Functionalized Diamond Nanoparticles. In Vivo Studies Based on ¹⁸F Radionuclide Emission. *ACS Nano* **2011**, *5*, 5552–5559. [CrossRef]

131. Jang, S.-C.; Kang, S.-M.; Lee, J.Y.; Oh, S.Y.; Vilian, A.E.; Lee, I.; Han, Y.-K.; Park, J.H.; Cho, W.-S.; Roh, C.; et al. Nano-Graphene Oxide Composite for in Vivo Imaging. *Int. J. Nanomed.* **2018**, *13*, 221–234. [CrossRef] [PubMed]

132. Riley, P.R.; Narayan, R.J. Recent Advances in Carbon Nanomaterials for Biomedical Applications: A Review. *Curr. Opin. Biomed. Eng.* **2021**, *17*, 100262. [CrossRef] [PubMed]

133. Peng, F.; Su, Y.; Zhong, Y.; Fan, C.; Lee, S.-T.; He, Y. Silicon Nanomaterials Platform for Bioimaging, Biosensing, and Cancer Therapy. *Acc. Chem. Res.* **2014**, *47*, 612–623. [CrossRef] [PubMed]

134. Salonen, J.; Mäkilä, E. Thermally Carbonized Porous Silicon and Its Recent Applications. *Adv. Mater.* **2018**, *30*, 1703819. [CrossRef] [PubMed]

135. Sarparanta, M.; Mäkilä, E.; Heikkilä, T.; Salonen, J.; Kukk, E.; Lehto, V.-P.; Santos, H.A.; Hirvonen, J.; Airaksinen, A.J. ¹⁸F-Labeled Modified Porous Silicon Particles for Investigation of Drug Delivery Carrier Distribution in Vivo with Positron Emission Tomography. *Mol. Pharm.* **2011**, *8*, 1799–1806. [CrossRef] [PubMed]

136. Bimbo, L.M.; Sarparanta, M.; Santos, H.A.; Airaksinen, A.J.; Mäkilä, E.; Laaksonen, T.; Peltonen, L.; Lehto, V.-P.; Hirvonen, J.; Salonen, J. Biocompatibility of Thermally Hydrocarbonized Porous Silicon Nanoparticles and Their Biodistribution in Rats. *ACS Nano* **2010**, *4*, 3023–3032. [CrossRef] [PubMed]

137. Sarparanta, M.; Bimbo, L.M.; Rytkönen, J.; Mäkilä, E.; Laaksonen, T.J.; Laaksonen, P.; Nyman, M.; Salonen, J.; Linder, M.B.; Hirvonen, J.; et al. Intravenous Delivery of Hydrophobin-Functionalized Porous Silicon Nanoparticles: Stability, Plasma Protein Adsorption and Biodistribution. *Mol. Pharm.* **2012**, *9*, 654–663. [CrossRef]

138. Keinänen, O.; Mäkilä, E.M.; Lindgren, R.; Virtanen, H.; Liljenbäck, H.; Oikonen, V.; Sarparanta, M.; Molthoff, C.; Windhorst, A.D.; Roivainen, A.; et al. Pretargeted PET Imaging of *Trans*-Cyclooctene-Modified Porous Silicon Nanoparticles. *ACS Omega* **2017**, *2*, 62–69. [CrossRef]

139. Jeelani, P.G.; Mulay, P.; Venkat, R.; Ramalingam, C. Multifaceted Application of Silica Nanoparticles. A Review. *Silicon* **2020**, *12*, 1337–1354. [CrossRef]

140. Liberman, A.; Mendez, N.; Trogler, W.C.; Kummel, A.C. Synthesis and Surface Functionalization of Silica Nanoparticles for Nanomedicine. *Surf. Sci. Rep.* **2014**, *69*, 132–158. [CrossRef]

141. Janjua, T.I.; Cao, Y.; Yu, C.; Popat, A. Clinical Translation of Silica Nanoparticles. *Nat. Rev. Mater.* **2021**, *6*, 1072–1074. [CrossRef] [PubMed]

142. Rastegari, E.; Hsiao, Y.-J.; Lai, W.-Y.; Lai, Y.-H.; Yang, T.-C.; Chen, S.-J.; Huang, P.-I.; Chiou, S.-H.; Mou, C.-Y.; Chien, Y. An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine. *Pharmaceutics* **2021**, *13*, 1067. [CrossRef] [PubMed]

143. Rojas, S.; Gispert, J.D.; Menchón, C.; Baldoví, H.G.; Buaki-Sogo, M.; Rocha, M.; Abad, S.; Victor, V.M.; García, H.; Herance, J.R. Novel Methodology for Labelling Mesoporous Silica Nanoparticles Using the ¹⁸F Isotope and Their in Vivo Biodistribution by Positron Emission Tomography. *J. Nanoparticle Res.* **2015**, *17*, 131. [CrossRef]

144. Lee, S.B.; Kim, H.L.; Jeong, H.; Lim, S.T.; Sohn, M.; Kim, D.W. Mesoporous Silica Nanoparticle Pretargeting for PET Imaging Based on a Rapid Bioorthogonal Reaction in a Living Body. *Angew. Chem. Int. Ed.* **2013**, *52*, 10549–10552. [CrossRef] [PubMed]

145. Rezaei Aghdam, H.; Bitarafan Rajabi, A.; Sadat Ebrahimi, S.E.; Beiki, D.; Abdi, K.; Mousavi Motlagh, S.S.; Kiani Dehkordi, B.; Darbandi Azar, A.; Shafiee Ardestani, M. ¹⁸F-FDG MicroPET and MRI Targeting Breast Cancer Mouse Model with Designed Synthesis Nanoparticles. *J. Nanomater.* **2022**, *2022*, 5737835. [CrossRef]

146. Do Carmo, S.J.C.; De Oliveira, P.M.; Alves, F. Thermal Simulation Studies for the Characterization of a Cyclotron Liquid Target with Thick Niobium Target Windows. *Appl. Sci.* **2021**, *11*, 10922. [CrossRef]

147. Jakubowska, T.; Długosz-Lisiecka, M.; Biegała, M. Comparison of Radionuclide Impurities Activated during Irradiation of ¹⁸O-Enriched Water in Tantalum and Silver Targets during the Production of ¹⁸F in a Cyclotron. *Molecules* **2023**, *28*, 3485. [CrossRef] [PubMed]

148. Ozkaya, F.; Unak, P.; Medine, E.I.; Sakarya, S.; Unak, G.; Timur, S. ¹⁸FDG Conjugated Magnetic Nanoparticle Probes: Synthesis and in Vitro Investigations on MCF-7 Breast Cancer Cells. *J. Radioanal. Nucl. Chem.* **2013**, *295*, 1789–1796. [CrossRef]

149. Wester, H.J.; Hamacher, K.; Stöcklin, G. A Comparative Study of N.C.A. Fluorine-18 Labeling of Proteins via Acylation and Photochemical Conjugation. *Nucl. Med. Biol.* **1996**, *23*, 365–372. [CrossRef]

150. Liu, Z.; Pourghiasian, M.; Radtke, M.A.; Lau, J.; Pan, J.; Dias, G.M.; Yapp, D.; Lin, K.-S.; Bénard, F.; Perrin, D.M. An Organotrifluoro-borate for Broadly Applicable One-Step 18F-Labeling. *Angew. Chem.* **2014**, *53*, 11876–11880. [CrossRef]

151. Lin, J.; Wang, W.; Li, K.; Huang, H.; Lv, G.; Peng, Y.; Luo, S.; Qiu, L. Development of a Kit-like Radiofluorinated Biomolecule Leading to a Controlled Self-Assembly of ¹⁸F Nanoparticles for a Smart PET Imaging Application. *Chem. Commun.* **2017**, *53*, 6476–6479. [CrossRef]

152. Keliher, E.J.; Ye, Y.-X.; Wojtkiewicz, G.R.; Aguirre, A.D.; Tricot, B.; Senders, M.L.; Groenen, H.; Fay, F.; Perez-Medina, C.; Calcagno, C.; et al. Polyglucose Nanoparticles with Renal Elimination and Macrophage Avidity Facilitate PET Imaging in Ischaemic Heart Disease. *Nat. Commun.* **2017**, *8*, 14064. [CrossRef]

153. Mirfeizi, L.; Walsh, J.; Kolb, H.; Campbell-Verduyn, L.; Dierckx, R.; Feringa, B.; Elsinga, P.; Groot, T.; Sannen, I.; Bormans, G.; et al. Synthesis of [¹⁸F]RGD-K5 by Catalyzed [3+2] Cycloaddition for Imaging Integrin Avβ3 Expression in Vivo. *Nucl. Med. Biol.* **2013**, *40*, 710–716. [CrossRef]
130. Rojas, S.; Gispert, J.D.; Martín, R.; Abad, S.; Menchón, C.; Pareto, D.; Víctor, V.M.; Álvaro, M.; García, H.; Herance, J.R. Biodistribution of Amino-Functionalized Diamond Nanoparticles. In Vivo Studies Based on ¹⁸F Radionuclide Emission. *ACS Nano* **2011**, *5*, 5552–5559. [CrossRef]

131. Jang, S.-C.; Kang, S.-M.; Lee, J.Y.; Oh, S.Y.; Vilian, A.E.; Lee, I.; Han, Y.-K.; Park, J.H.; Cho, W.-S.; Roh, C.; et al. Nano-Graphene Oxide Composite for in Vivo Imaging. *Int. J. Nanomed.* **2018**, *13*, 221–234. [CrossRef] [PubMed]

132. Riley, P.R.; Narayan, R.J. Recent Advances in Carbon Nanomaterials for Biomedical Applications: A Review. *Curr. Opin. Biomed. Eng.* **2021**, *17*, 100262. [CrossRef] [PubMed]

133. Peng, F.; Su, Y.; Zhong, Y.; Fan, C.; Lee, S.-T.; He, Y. Silicon Nanomaterials Platform for Bioimaging, Biosensing, and Cancer Therapy. *Acc. Chem. Res.* **2014**, *47*, 612–623. [CrossRef] [PubMed]

134. Salonen, J.; Mäkilä, E. Thermally Carbonized Porous Silicon and Its Recent Applications. *Adv. Mater.* **2018**, *30*, 1703819. [CrossRef] [PubMed]

135. Sarparanta, M.; Mäkilä, E.; Heikkilä, T.; Salonen, J.; Kukk, E.; Lehto, V.-P.; Santos, H.A.; Hirvonen, J.; Airaksinen, A.J. ¹⁸F-Labeled Modified Porous Silicon Particles for Investigation of Drug Delivery Carrier Distribution in Vivo with Positron Emission Tomography. *Mol. Pharm.* **2011**, *8*, 1799–1806. [CrossRef] [PubMed]

136. Bimbo, L.M.; Sarparanta, M.; Santos, H.A.; Airaksinen, A.J.; Mäkilä, E.; Laaksonen, T.; Peltonen, L.; Lehto, V.-P.; Hirvonen, J.; Salonen, J. Biocompatibility of Thermally Hydrocarbonized Porous Silicon Nanoparticles and Their Biodistribution in Rats. *ACS Nano* **2010**, *4*, 3023–3032. [CrossRef] [PubMed]

137. Sarparanta, M.; Bimbo, L.M.; Rytkönen, J.; Mäkilä, E.; Laaksonen, T.J.; Laaksonen, P.; Nyman, M.; Salonen, J.; Linder, M.B.; Hirvonen, J.; et al. Intravenous Delivery of Hydrophobin-Functionalized Porous Silicon Nanoparticles: Stability, Plasma Protein Adsorption and Biodistribution. *Mol. Pharm.* **2012**, *9*, 654–663. [CrossRef]

138. Keinänen, O.; Mäkilä, E.M.; Lindgren, R.; Virtanen, H.; Liljenbäck, H.; Oikonen, V.; Sarparanta, M.; Molthoff, C.; Windhorst, A.D.; Roivainen, A.; et al. Pretargeted PET Imaging of *Trans*-Cyclooctene-Modified Porous Silicon Nanoparticles. *ACS Omega* **2017**, *2*, 62–69. [CrossRef]

139. Jeelani, P.G.; Mulay, P.; Venkat, R.; Ramalingam, C. Multifaceted Application of Silica Nanoparticles. A Review. *Silicon* **2020**, *12*, 1337–1354. [CrossRef]

140. Liberman, A.; Mendez, N.; Trogler, W.C.; Kummel, A.C. Synthesis and Surface Functionalization of Silica Nanoparticles for Nanomedicine. *Surf. Sci. Rep.* **2014**, *69*, 132–158. [CrossRef]

141. Janjua, T.I.; Cao, Y.; Yu, C.; Popat, A. Clinical Translation of Silica Nanoparticles. *Nat. Rev. Mater.* **2021**, *6*, 1072–1074. [CrossRef] [PubMed]

142. Rastegari, E.; Hsiao, Y.-J.; Lai, W.-Y.; Lai, Y.-H.; Yang, T.-C.; Chen, S.-J.; Huang, P.-I.; Chiou, S.-H.; Mou, C.-Y.; Chien, Y. An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine. *Pharmaceutics* **2021**, *13*, 1067. [CrossRef] [PubMed]

143. Rojas, S.; Gispert, J.D.; Menchón, C.; Baldoví, H.G.; Buaki-Sogo, M.; Rocha, M.; Abad, S.; Victor, V.M.; García, H.; Herance, J.R. Novel Methodology for Labelling Mesoporous Silica Nanoparticles Using the ¹⁸F Isotope and Their in Vivo Biodistribution by Positron Emission Tomography. *J. Nanoparticle Res.* **2015**, *17*, 131. [CrossRef]

144. Lee, S.B.; Kim, H.L.; Jeong, H.; Lim, S.T.; Sohn, M.; Kim, D.W. Mesoporous Silica Nanoparticle Pretargeting for PET Imaging Based on a Rapid Bioorthogonal Reaction in a Living Body. *Angew. Chem. Int. Ed.* **2013**, *52*, 10549–10552. [CrossRef] [PubMed]

145. Rezaei Aghdam, H.; Bitarafan Rajabi, A.; Sadat Ebrahimi, S.E.; Beiki, D.; Abdi, K.; Mousavi Motlagh, S.S.; Kiani Dehkordi, B.; Darbandi Azar, A.; Shafiee Ardestani, M. ¹⁸F-FDG MicroPET and MRI Targeting Breast Cancer Mouse Model with Designed Synthesis Nanoparticles. *J. Nanomater.* **2022**, *2022*, 5737835. [CrossRef]

146. Do Carmo, S.J.C.; De Oliveira, P.M.; Alves, F. Thermal Simulation Studies for the Characterization of a Cyclotron Liquid Target with Thick Niobium Target Windows. *Appl. Sci.* **2021**, *11*, 10922. [CrossRef]

147. Jakubowska, T.; Długosz-Lisiecka, M.; Biegała, M. Comparison of Radionuclide Impurities Activated during Irradiation of ¹⁸O-Enriched Water in Tantalum and Silver Targets during the Production of ¹⁸F in a Cyclotron. *Molecules* **2023**, *28*, 3485. [CrossRef] [PubMed]

148. Ozkaya, F.; Unak, P.; Medine, E.I.; Sakarya, S.; Unak, G.; Timur, S. ¹⁸FDG Conjugated Magnetic Nanoparticle Probes: Synthesis and in Vitro Investigations on MCF-7 Breast Cancer Cells. *J. Radioanal. Nucl. Chem.* **2013**, *295*, 1789–1796. [CrossRef]

149. Wester, H.J.; Hamacher, K.; Stöcklin, G. A Comparative Study of N.C.A. Fluorine-18 Labeling of Proteins via Acylation and Photochemical Conjugation. *Nucl. Med. Biol.* **1996**, *23*, 365–372. [CrossRef]

150. Liu, Z.; Pourghiasian, M.; Radtke, M.A.; Lau, J.; Pan, J.; Dias, G.M.; Yapp, D.; Lin, K.-S.; Bénard, F.; Perrin, D.M. An Organotrifluoro-borate for Broadly Applicable One-Step 18F-Labeling. *Angew. Chem.* **2014**, *53*, 11876–11880. [CrossRef]

151. Lin, J.; Wang, W.; Li, K.; Huang, H.; Lv, G.; Peng, Y.; Luo, S.; Qiu, L. Development of a Kit-like Radiofluorinated Biomolecule Leading to a Controlled Self-Assembly of ¹⁸F Nanoparticles for a Smart PET Imaging Application. *Chem. Commun.* **2017**, *53*, 6476–6479. [CrossRef]

152. Keliher, E.J.; Ye, Y.-X.; Wojtkiewicz, G.R.; Aguirre, A.D.; Tricot, B.; Senders, M.L.; Groenen, H.; Fay, F.; Perez-Medina, C.; Calcagno, C.; et al. Polyglucose Nanoparticles with Renal Elimination and Macrophage Avidity Facilitate PET Imaging in Ischaemic Heart Disease. *Nat. Commun.* **2017**, *8*, 14064. [CrossRef]

153. Mirfeizi, L.; Walsh, J.; Kolb, H.; Campbell-Verduyn, L.; Dierckx, R.; Feringa, B.; Elsinga, P.; Groot, T.; Sannen, I.; Bormans, G.; et al. Synthesis of [¹⁸F]RGD-K5 by Catalyzed [3+2] Cycloaddition for Imaging Integrin Avβ3 Expression in Vivo. *Nucl. Med. Biol.* **2013**, *40*, 710–716. [CrossRef]
154. de Bruin, B.; Kuhnast, B.; Hinnen, F.; Yaouancq, L.; Amessou, M.; Johannes, L.; Samson, A.; Boisgard, R.; Tavitian, B.; Dollé, F. 1-[3-(2-[¹⁸F]Fluoropyridin-3-Yloxy)Propyl]Pyrrole-2,5-Dione: Design, Synthesis, and Radiosynthesis of a New [¹⁸F]Fluoropyridine-Based Maleimide Reagent for the Labeling of Peptides and Proteins. *Bioconjug. Chem.* **2005**, *16*, 406–420. [CrossRef]

155. Ma, Y.; Liang, S.; Guo, J.; Wang, H. ¹⁸F-Radiolabeled RGD-A7R-Conjugated Nano-Particles for Integrin and VEGF-Targeted Tumor Imaging. *J. Radioanal. Nucl. Chem.* **2016**, *308*, 741–746. [CrossRef]

156. Dammicco, S.; Goux, M.; Lemaire, C.; Becker, G.; Bahri, M.A.; Plenevaux, A.; Cinier, M.; Luxen, A. Regiospecific Radiolabelling of Nanofitin on Ni Magnetic Beads with [¹⁸F]FBEM and in Vivo PET Studies. *Nucl. Med. Biol.* **2017**, *51*, 33–39. [CrossRef]

157. Wängler, B.; Quandt, G.; Iovkova, L.; Schirrmacher, E.; Wängler, C.; Boening, G.; Hacker, M.; Schmoeckel, M.; Jurkschat, K.; Bartenstein, P.; et al. Kit-Like ¹⁸F-Labeling of Proteins: Synthesis of 4-(Di- *Tert*-Butyl[¹⁸F]Fluorosilyl)Benzenethiol (Si[¹⁸F]FA-SH) Labeled Rat Serum Albumin for Blood Pool Imaging with PET. *Bioconjug. Chem.* **2009**, *20*, 317–321. [CrossRef]

158. Hong, H.; Zhang, L.; Xie, F.; Zhuang, R.; Jiang, D.; Liu, H.; Li, J.; Yang, H.; Zhang, X.; Nie, L.; et al. Rapid One-Step ¹⁸F-Radiolabeling of Biomolecules in Aqueous Media by Organophosphine Fluoride Acceptors. *Nat. Commun.* **2019**, *10*, 989. [CrossRef]

159. Stockhofe, K.; Postema, J.; Schieferstein, H.; Ross, T. Radiolabeling of Nanoparticles and Polymers for PET Imaging. *Pharmaceuticals* **2014**, *7*, 392–418. [CrossRef] [PubMed]

160. Lamb, J.; Holland, J.P. Advanced Methods for Radiolabeling Multimodality Nanomedicines for SPECT/MRI and PET/MRI. *J. Nucl. Med.* **2018**, *59*, 382–389. [CrossRef] [PubMed]

161. Farzin, L.; Sheibani, S.; Moassesi, M.E.; Shamsipur, M. An Overview of Nanoscale Radionuclides and Radiolabeled Nanomaterials Commonly Used for Nuclear Molecular Imaging and Therapeutic Functions. *J. Biomed. Mater. Res. A* **2019**, *107*, 251–285. [CrossRef]

162. Ranjbar Bahadori, S.; Mulgaonkar, A.; Hart, R.; Wu, C.; Zhang, D.; Pillai, A.; Hao, Y.; Sun, X. Radiolabeling Strategies and Pharmacokinetic Studies for Metal Based Nanotheranostics. *WIREs Nanomed. Nanobiotechnol.* **2021**, *13*, e1671. [CrossRef]

163. Molavipordanjani, S.; Tolmachev, V.; Hosseinimehr, S.J. Basic and Practical Concepts of Radiopharmaceutical Purification Methods. *Drug Discov. Today* **2019**, *24*, 315–324. [CrossRef]

164. Huclier-Markai, S.; Alliot, C.; Battu, S. Nanoparticles in Radiopharmaceutical Sciences: Review of the Fundamentals, Characterization Techniques and Future Challenges. *J. Mater. Nanosci.* **2020**, *7*, 36–61.

165. Goel, M.; Mackeyev, Y.; Krishnan, S. Radiolabeled Nanomaterial for Cancer Diagnostics and Therapeutics: Principles and Concepts. *Cancer Nanotechnol.* **2023**, *14*, 15. [CrossRef]

166. Oku, N.; Tokudome, Y.; Namba, Y.; Saito, N.; Endo, M.; Hasegawa, Y.; Kawai, M.; Tsukada, H.; Okada, S. Effect of Serum Protein Binding on Real-Time Trafficking of Liposomes with Different Charges Analyzed by Positron Emission Tomography. *Biochim. Biophys. Acta BBA-Biomembr.* **1996**, *1280*, 149–154. [CrossRef]

167. Allmeroth, M.; Moderegger, D.; Biesalski, B.; Koynov, K.; Rösch, F.; Thews, O.; Zentel, R. Modifying the Body Distribution of HPMA-Based Copolymers by Molecular Weight and Aggregate Formation. *Biomacromolecules* **2011**, *12*, 2841–2849. [CrossRef]

168. Wenzel, B.; Schmid, M.; Teodoro, R.; Moldovan, R.-P.; Lai, T.H.; Mitrach, F.; Kopka, K.; Fischer, B.; Schulz-Siegmund, M.; Brust, P.; et al. Radiofluorination of an Anionic, Azide-Functionalized Teroligomer by Copper-Catalyzed Azide-Alkyne Cycloaddition. *Nanomaterials* **2023**, *13*, 2095. [CrossRef]

169. Silva, F.; Cabral Campello, M.P.; Paulo, A. Radiolabeled Gold Nanoparticles for Imaging and Therapy of Cancer. *Materials* **2021**, *14*, 4. [CrossRef] [PubMed]

170. Unak, G.; Ozkaya, F.; Ilker Medine, E.; Kozgus, O.; Sakarya, S.; Bekis, R.; Unak, P.; Timur, S. Gold Nanoparticle Probes: Design and in Vitro Applications in Cancer Cell Culture. *Colloids Surf. B Biointerfaces* **2012**, *90*, 217–226. [CrossRef] [PubMed]

171. García-Vázquez, R.; Battisti, U.M.; Jørgensen, J.T.; Shalgunov, V.; Hvass, L.; Stares, D.L.; Petersen, I.N.; Crestey, F.; Löffler, A.; Svatunek, D.; et al. Direct Cu-Mediated Aromatic 18F-Labeling of Highly Reactive Tetrazines for Pretargeted Bioorthogonal PET Imaging. *Chem. Sci.* **2021**, *12*, 11668–11675. [CrossRef]

172. Simó, C.; Serra-Casablancas, M.; Hortelao, A.C.; Di Carlo, V.; Guallar-Garrido, S.; Plaza-García, S.; Rabanal, R.M.; Ramos-Cabrer, P.; Yagüe, B.; Aguado, L.; et al. Urease-Powered Nanobots for Radionuclide Bladder Cancer Therapy. *Nat. Nanotechnol.* **2024**. [CrossRef]

173. Idiago-López, J.; Moreno-Antolín, E.; De La Fuente, J.M.; Fratila, R.M. Nanoparticles and Bioorthogonal Chemistry Joining Forces for Improved Biomedical Applications. *Nanoscale Adv.* **2021**, *3*, 1261–1292. [CrossRef]

174. Huang, Z.; Hu, Y.; Yang, Y.; Huang, W.; Wang, Y.; Ye, D. Recent Advances in Pretargeted Imaging of Tumors in Vivo. *Anal. Sens.* **2022**, *2*, e202200013. [CrossRef]

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154. de Bruin, B.; Kuhnast, B.; Hinnen, F.; Yaouancq, L.; Amessou, M.; Johannes, L.; Samson, A.; Boisgard, R.; Tavitian, B.; Dollé, F. 1-[3-(2-[¹⁸F]Fluoropyridin-3-Yloxy)Propyl]Pyrrole-2,5-Dione: Design, Synthesis, and Radiosynthesis of a New [¹⁸F]Fluoropyridine-Based Maleimide Reagent for the Labeling of Peptides and Proteins. *Bioconjug. Chem.* **2005**, *16*, 406–420. [CrossRef]

155. Ma, Y.; Liang, S.; Guo, J.; Wang, H. ¹⁸F-Radiolabeled RGD-A7R-Conjugated Nano-Particles for Integrin and VEGF-Targeted Tumor Imaging. *J. Radioanal. Nucl. Chem.* **2016**, *308*, 741–746. [CrossRef]

156. Dammicco, S.; Goux, M.; Lemaire, C.; Becker, G.; Bahri, M.A.; Plenevaux, A.; Cinier, M.; Luxen, A. Regiospecific Radiolabelling of Nanofitin on Ni Magnetic Beads with [¹⁸F]FBEM and in Vivo PET Studies. *Nucl. Med. Biol.* **2017**, *51*, 33–39. [CrossRef]

157. Wängler, B.; Quandt, G.; Iovkova, L.; Schirrmacher, E.; Wängler, C.; Boening, G.; Hacker, M.; Schmoeckel, M.; Jurkschat, K.; Bartenstein, P.; et al. Kit-Like ¹⁸F-Labeling of Proteins: Synthesis of 4-(Di- *Tert* -Butyl[¹⁸F]Fluorosilyl)Benzenethiol (Si[¹⁸F]FA-SH) Labeled Rat Serum Albumin for Blood Pool Imaging with PET. *Bioconjug. Chem.* **2009**, *20*, 317–321. [CrossRef]

158. Hong, H.; Zhang, L.; Xie, F.; Zhuang, R.; Jiang, D.; Liu, H.; Li, J.; Yang, H.; Zhang, X.; Nie, L.; et al. Rapid One-Step ¹⁸F-Radiolabeling of Biomolecules in Aqueous Media by Organophosphine Fluoride Acceptors. *Nat. Commun.* **2019**, *10*, 989. [CrossRef]

159. Stockhofe, K.; Postema, J.; Schieferstein, H.; Ross, T. Radiolabeling of Nanoparticles and Polymers for PET Imaging. *Pharmaceuticals* **2014**, *7*, 392–418. [CrossRef] [PubMed]

160. Lamb, J.; Holland, J.P. Advanced Methods for Radiolabeling Multimodality Nanomedicines for SPECT/MRI and PET/MRI. *J. Nucl. Med.* **2018**, *59*, 382–389. [CrossRef] [PubMed]

161. Farzin, L.; Sheibani, S.; Moassesi, M.E.; Shamsipur, M. An Overview of Nanoscale Radionuclides and Radiolabeled Nanomaterials Commonly Used for Nuclear Molecular Imaging and Therapeutic Functions. *J. Biomed. Mater. Res. A* **2019**, *107*, 251–285. [CrossRef]

162. Ranjbar Bahadori, S.; Mulgaonkar, A.; Hart, R.; Wu, C.; Zhang, D.; Pillai, A.; Hao, Y.; Sun, X. Radiolabeling Strategies and Pharmacokinetic Studies for Metal Based Nanotheranostics. *WIREs Nanomed. Nanobiotechnol.* **2021**, *13*, e1671. [CrossRef]

163. Molavipordanjani, S.; Tolmachev, V.; Hosseinimehr, S.J. Basic and Practical Concepts of Radiopharmaceutical Purification Methods. *Drug Discov. Today* **2019**, *24*, 315–324. [CrossRef]

164. Huclier-Markai, S.; Alliot, C.; Battu, S. Nanoparticles in Radiopharmaceutical Sciences: Review of the Fundamentals, Characterization Techniques and Future Challenges. *J. Mater. Nanosci.* **2020**, *7*, 36–61.

165. Goel, M.; Mackeyev, Y.; Krishnan, S. Radiolabeled Nanomaterial for Cancer Diagnostics and Therapeutics: Principles and Concepts. *Cancer Nanotechnol.* **2023**, *14*, 15. [CrossRef]

166. Oku, N.; Tokudome, Y.; Namba, Y.; Saito, N.; Endo, M.; Hasegawa, Y.; Kawai, M.; Tsukada, H.; Okada, S. Effect of Serum Protein Binding on Real-Time Trafficking of Liposomes with Different Charges Analyzed by Positron Emission Tomography. *Biochim. Biophys. Acta BBA-Biomembr.* **1996**, *1280*, 149–154. [CrossRef]

167. Allmeroth, M.; Moderegger, D.; Biesalski, B.; Koynov, K.; Rösch, F.; Thews, O.; Zentel, R. Modifying the Body Distribution of HPMA-Based Copolymers by Molecular Weight and Aggregate Formation. *Biomacromolecules* **2011**, *12*, 2841–2849. [CrossRef]

168. Wenzel, B.; Schmid, M.; Teodoro, R.; Moldovan, R.-P.; Lai, T.H.; Mitrach, F.; Kopka, K.; Fischer, B.; Schulz-Siegmund, M.; Brust, P.; et al. Radiofluorination of an Anionic, Azide-Functionalized Teroligomer by Copper-Catalyzed Azide-Alkyne Cycloaddition. *Nanomaterials* **2023**, *13*, 2095. [CrossRef]

169. Silva, F.; Cabral Campello, M.P.; Paulo, A. Radiolabeled Gold Nanoparticles for Imaging and Therapy of Cancer. *Materials* **2021**, *14*, 4. [CrossRef] [PubMed]

170. Unak, G.; Ozkaya, F.; Ilker Medine, E.; Kozgus, O.; Sakarya, S.; Bekis, R.; Unak, P.; Timur, S. Gold Nanoparticle Probes: Design and in Vitro Applications in Cancer Cell Culture. *Colloids Surf. B Biointerfaces* **2012**, *90*, 217–226. [CrossRef] [PubMed]

171. García-Vázquez, R.; Battisti, U.M.; Jørgensen, J.T.; Shalgunov, V.; Hvass, L.; Stares, D.L.; Petersen, I.N.; Crestey, F.; Löffler, A.; Svatunek, D.; et al. Direct Cu-Mediated Aromatic 18F-Labeling of Highly Reactive Tetrazines for Pretargeted Bioorthogonal PET Imaging. *Chem. Sci.* **2021**, *12*, 11668–11675. [CrossRef]

172. Simó, C.; Serra-Casablancas, M.; Hortelao, A.C.; Di Carlo, V.; Guallar-Garrido, S.; Plaza-García, S.; Rabanal, R.M.; Ramos-Cabrer, P.; Yagüe, B.; Aguado, L.; et al. Urease-Powered Nanobots for Radionuclide Bladder Cancer Therapy. *Nat. Nanotechnol.* **2024**. [CrossRef]

173. Idiago-López, J.; Moreno-Antolín, E.; De La Fuente, J.M.; Fratila, R.M. Nanoparticles and Bioorthogonal Chemistry Joining Forces for Improved Biomedical Applications. *Nanoscale Adv.* **2021**, *3*, 1261–1292. [CrossRef]

174. Huang, Z.; Hu, Y.; Yang, Y.; Huang, W.; Wang, Y.; Ye, D. Recent Advances in Pretargeted Imaging of Tumors in Vivo. *Anal. Sens.* **2022**, *2*, e202200013. [CrossRef]

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