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# Exploring the diversity of brominated alkaloids naturally released by the sponge Aplysina cavernicola

Morgane Mauduit, Stephane Greff, Thierry Pérez, Charlotte Simmler

► To cite this version:

Morgane Mauduit, Stephane Greff, Thierry Pérez, Charlotte Simmler. Exploring the diversity of brominated alkaloids naturally released by the sponge Aplysina cavernicola. XII European Conference on Marine Natural Products, Aug 2021, Galway, Ireland. , 10.5281/zenodo.5654969 . hal-03857528

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https://hal.science/hal-03857528

Submitted on 17 Nov 2022

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# Exploring the diversity of brominated alkaloids naturally released by the sponge *Aplysina cavernicola*

SESAM
project

Morgane MAUDUIT¹, Stéphane GREFF¹, Thierry PEREZ¹, Charlotte SIMMLER¹

¹ Institut Méditerranéen de Biodiversité et d'Écologie Marine et Continentale, UMR 7263

Endoume Marine Station, Rue de la batterie des lions, 13007 Marseille (e-mail: morgane.mauduit@imbe.fr)

## Context

* *Aplysina* species are marine sponges known to produce **spiro-isoxazoline bromotyrosine** alkaloids (e.g. aerothionin).

* It has been reported that the Caribbean sponge *A. fistularis* releases aerothionin in seawater with/without intentional stress.¹

* Such released compounds, herein called **exo-metabolites (EM)**, could possibly exert their biological effects as marine chemical cues.²

The present study aims at determining (1) whether the Mediterranean sponge *Aplysina cavernicola* (Vacelet, 1959) naturally releases brominated alkaloids other than aerothionin, (2) what are their identity and, (3) in what proportions are they released.

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A. cavernicola

## General Experimental Workflow

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## References:

¹ Walker, R. P. et al. Mar Biol 88, 27-32 (1985), ²Santonja, M., et al. Mar Biol 165, 121 (2018)

This work is funded by ANR-20-CE-43-0003 (program SESAM)

MM Ph.D. is funded by a CNRS fellowship

MM participation to the XII ECMNP is funded by the GDR n°3658 MediatEC

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