# Supplementary data to: Pregnancy outcomes in women
wiht pre-existing thyroid diseases: a french cohort study

Marion Lecorguillé, Juliane Léger, Anne Forhan, Marie Cheminat,
Marie-Noëlle Dufourg, Barbara Heude, Marie-Aline Charles

► To cite this version:

Marion Lecorguillé, Juliane Léger, Anne Forhan, Marie Cheminat, Marie-Noëlle Dufourg, et al. Supplementary data to: Pregnancy outcomes in women wiht pre-existing thyroid diseases: a french cohort study. 2018. inserm-01904665

HAL Id: inserm-01904665

https://inserm.hal.science/inserm-01904665

Submitted on 25 Oct 2018

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# SUPPLEMENTARY DATA.

## PREGNANCY OUTCOMES IN WOMEN WITH PRE-EXISTING THYROID DISEASES: A FRENCH COHORT STUDY

Marion Lecorguillé*<fnref n="1" />,<fnref n="2" />, Juliane Léger<fnref n="3" />,<fnref n="4" />,<fnref n="5" />, Anne Forhan<fnref n="1" />,<fnref n="2" />, Marie Cheminat<fnref n="6" />, Marie-Noëlle Dufourg<fnref n="6" />, Barbara Heude<fnref n="1" />,<fnref n="2" />*, Marie-Aline Charles<fnref n="1" />,<fnref n="2" />,<fnref n="6" />*

<table><tr><td>Supplementary Table 1.</td><td>Outcomes for women with and without pre-pregnancy thyroid diseases.</td></tr><tr><td>Supplementary Table 2.</td><td>Comparison of outcomes for women without pre-pregnancy thyroid diseases and with pre-pregnancy hypothyroidism (hyperthyroidism or unspecified thyroid diseases excluded).</td></tr></table>

<footnote n="1">¹INSERM UMR1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Team “Early Origins of the Child’s Health and Development” (ORCHAD), Paris, France.</footnote>

<footnote n="2">²Paris Descartes University, Sorbonne Paris Cité, F-75005 Paris, France.</footnote>

<footnote n="3">³Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1141, DHU Protect, F-75019 Paris, France.</footnote>

<footnote n="4">⁴Paris Diderot University, Sorbonne Paris Cité, F-75019 Paris, France.</footnote>

<footnote n="5">⁵Assistance Publique-Hôpitaux de Paris, Robert Debré University Hospital, Pediatric Endocrinology Diabetology Department, Reference Center for Growth and Development Endocrine Diseases, F-75019 Paris, France.</footnote>

<footnote n="6">⁶Ined-Inserm-EFS joint Unit Elfe, Paris, F-75980</footnote>
<table><caption>Table 1: Outcomes for women with and without pre-pregnancy thyroid diseases.</caption><thead><tr><th>Fertility and pregnancy complications</th><th>N</th><th>No pre-pregnancy thyroid diseases (N=16122)</th><th>Pre-pregnancy thyroid diseases (N=273)</th><th>P-value</th></tr></thead><tbody><tr><td>Infertility treatment</td><td>16230</td><td>7.0 (1124)</td><td>11.7 (31)</td><td>0.004</td></tr><tr><td>Gestational diabetes</td><td>15826</td><td>7.5 (1165)</td><td>11.9 (32)</td><td>0.006</td></tr><tr><td>Gestational age at birth (amenorrhea weeks)</td><td>16302</td><td>39.6 ± 1.4</td><td>39.7 ± 1.3</td><td>0.73</td></tr><tr><td>Hospitalization during pregnancy</td><td>16301</td><td>15.3 (2455)</td><td>18.8 (51)</td><td>0.12</td></tr><tr><td>Induction of labor</td><td>16277</td><td></td><td></td><td>0.32</td></tr><tr><td>Spontaneous labor</td><td></td><td>72.1 (11535)</td><td>68.8 (187)</td><td></td></tr><tr><td>Induction</td><td></td><td>19.3 (3084)</td><td>20.2 (55)</td><td></td></tr><tr><td>Pre-labor caesarean section</td><td></td><td>8.7 (1386)</td><td>11.0 (30)</td><td></td></tr><tr><td>Mode of delivery</td><td>16154</td><td></td><td></td><td>0.45</td></tr><tr><td>Vaginal delivery</td><td></td><td>69.7 (11073)</td><td>66.8 (181)</td><td></td></tr><tr><td>Assisted delivery*</td><td></td><td>12.9 (2041)</td><td>12.9 (35)</td><td></td></tr><tr><td>Caesarean section</td><td></td><td>17.4 (2769)</td><td>20.3 (55)</td><td></td></tr><tr><td>Premature rupture of membranes</td><td>16067</td><td>9.8 (1553)</td><td>12.3 (33)</td><td>0.18</td></tr><tr><td>Birth weight (g)</td><td>16198</td><td>3334.8 ± 478.4</td><td>3376 ± 460.3</td><td>0.16</td></tr><tr><td>Birth length (cm)</td><td>14967</td><td>49.6 ± 2.1</td><td>49.9 ± 2.0</td><td>0.05</td></tr><tr><td>Head circumference (cm)</td><td>14875</td><td>34.4 ± 1.4</td><td>34.4 ± 1.4</td><td>0.96</td></tr><tr><td>Birth weight categories**</td><td>15926</td><td></td><td></td><td>0.68</td></tr><tr><td>SGA</td><td></td><td>9.3 (1459)</td><td>7.8 (21)</td><td></td></tr><tr><td>AGA</td><td></td><td>80.8 (12646)</td><td>81.9 (221)</td><td></td></tr><tr><td>LGA</td><td></td><td>9.9 (1551)</td><td>10.4 (28)</td><td></td></tr></tbody></table>

Data are n (%) or mean ± SD.

* Assisted delivery: forceps, spatulas, vacuum

**A customized standard to assess fetal growth: SGA, small for gestational age (< 10th percentile); AGA, appropriate for gestational age (10th to 90th percentile); LGA, large gestational weight (>90th percentile)
<table><caption>Table 2: Comparison of outcomes for women without pre-pregnancy thyroid diseases and with pre-pregnancy hypothyroidism (hyperthyroidism or unspecified thyroid diseases excluded)</caption><thead><tr><th>Fertility and pregnancy complications</th><th>N</th><th>No Pre-pregnancy thyroid diseases (N=16122)</th><th>Pre-pregnancy hypothyroidism (N=196)</th><th>P-value</th><th>Adjusted model 2</th></tr></thead><tbody><tr><td>Infertility treatment</td><td>16155</td><td>7.0 (1124)</td><td>12.0 (23)</td><td><strong>0.007</strong></td><td>1.55 [0.99-2.43]</td></tr><tr><td>Gestational diabetes</td><td>15752</td><td>7.5 (1165)</td><td>12.4 (24)</td><td><strong>0.010</strong></td><td>1.24 [0.78-1.95]</td></tr><tr><td>Gestational age at birth (amenorrhea weeks)</td><td>16225</td><td>39.6 ± 1.4</td><td>39.6 ± 1.3</td><td>0.87</td><td>-0.04 [-0.24;0.16]</td></tr><tr><td>Hospitalization during pregnancy</td><td>16225</td><td>15.3 (2455)</td><td>16.3 (32)</td><td>0.70</td><td>1.10 [0.75-1.61]</td></tr><tr><td>Induction of labor</td><td>16201</td><td></td><td></td><td>0.31</td><td></td></tr><tr><td>Spontaneous labor</td><td></td><td>72.1 (11535)</td><td>69.4 (136)</td><td></td><td>ref</td></tr><tr><td>Induction</td><td></td><td>19.3 (3084)</td><td>18.9 (37)</td><td></td><td>0.90 [0.62-1.30]</td></tr><tr><td>Prelabor caesarean section</td><td></td><td>8.7 (1386)</td><td>11.7 (23)</td><td></td><td>1.11 [0.70-1.75]</td></tr><tr><td>Mode of delivery</td><td>16078</td><td></td><td></td><td>0.21</td><td></td></tr><tr><td>Vaginal delivery</td><td></td><td>69.7 (11073)</td><td>64.6 (126)</td><td></td><td>ref</td></tr><tr><td>Assisted delivery*</td><td></td><td>12.9 (2041)</td><td>13.3 (26)</td><td></td><td>1.11 [0.71-1.72]</td></tr><tr><td>Caesarean section</td><td></td><td>17.4 (2769)</td><td>22.1 (43)</td><td></td><td>1.12 [0.78-1.60]</td></tr><tr><td>Premature rupture of membranes</td><td>15991</td><td>9.8 (1553)</td><td>14.5 (28)</td><td><strong>0.030</strong></td><td>1.49 [0.99-2.27]</td></tr><tr><td>Birth weight (g)</td><td>16121</td><td>3334.8 ± 478.4</td><td>3366.8 ± 467.8</td><td>0.35</td><td>-0.20 [-55.9;55.5]</td></tr><tr><td>Birth length (cm)</td><td>14897</td><td>49.6 ± 2.1</td><td>49.8 ± 2.1</td><td>0.34</td><td>0.02 [-0.25;0.29]</td></tr><tr><td>Head circumference (cm)</td><td>14806</td><td>34.4 ± 1.4</td><td>34.3 ± 1.4</td><td>0.34</td><td><strong>-0.20 [-0.39;-0.01]</strong></td></tr><tr><td>Birth weight categories**</td><td>15851</td><td></td><td></td><td>0.86</td><td></td></tr><tr><td>SGA</td><td></td><td>9.3 (1459)</td><td>8.2 (16)</td><td></td><td>NA</td></tr><tr><td>AGA</td><td></td><td>80.8 (12646)</td><td>81.5 (159)</td><td></td><td></td></tr><tr><td>LGA</td><td></td><td>9.9 (1551)</td><td>10.3 (20)</td><td></td><td></td></tr></tbody></table>

Model 2: adjusted on maternal education level, maternal age, parity, smoking during pregnancy, BMI and infant sex and gestational age for head circumference, birth weight and length.

* Assisted delivery: forceps, spatulas, vacuum

** A customized standard to assess fetal growth: SGA, small for gestational age (< 10th percentile); AGA, appropriate for gestational age (10th to 90th percentile); LGA, large gestational weight (>90th percentile).