Introduction. Non-Hodgkin’s lymphomas (NHL) are hemopathies developed from cell precursors present in lymphoid organs and whose pathogenesis involves the production of abnormal lymphocytes, which could significantly affect CD4+ T-Lymphocyte levels (CD4+TL) during an NHL. Objective. To profile the CD4+TL variation rate, based on few clinical parameters in subjects with NHL. Methods. A cross-sectional study was conducted on NHL patients at Yaoundé General Hospital from October 2018 to March 2019. For each consenting patient, venous blood was collected and CD4+TL quantified by immunophenotyping. The studied characteristics were demographic, clinical and biological. Results. Forty participants were enrolled. Their average age was 51±16 years, with a sex ratio of 1.5. Weight loss and impaired overall condition were the main causes of clinical evolutivity. Lymph node location, aggressive lymphoma and advanced stage of disease were the most common clinical parameters in our population. The median number of LT CD4+ TL was 723 cells/mm3 and remained high regardless of the demographic and clinical endpoint used. Conclusion. Although lymphopenia remains a common trait in NHL patients according to the literature, our study showed a high CD4+ TL rate in these patients.