This study examined the influence of Total Quality Management (TQM) on enhancing institutional performance in private hospitals located in Sana’a City, employing a descriptive-analytical methodology and utilizing questionnaires for data collection. The sample comprised 10 private hospitals, with 211 medical and administrative staff participating. Findings revealed a significant positive impact of TQM on institutional performance, alongside high levels of both TQM implementation and overall performance within these hospitals. The study recommended greater emphasis on TQM as a holistic organizational strategy driven by senior management to deliver continuously improving healthcare services, prioritize beneficiary needs, base decisions on reliable data, and strengthen employee training to elevate institutional effectiveness.