# Development of a post-biotic as a Therapeutic Support for Managing Obesity-Linked Psoriasis

Arthur Chervet, Rawan Nehme, Clémence C. Defois-Fraysse Defois-Fraysse, Caroline Decombat, Bertrand Evrard, Edith Filaire, Jean-Yves Berthon, Assia Dreux-Zigha, Laetitia Delort, Florence Caldefie-Chezet

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## To cite this version:

Arthur Chervet, Rawan Nehme, Clémence C. Defois-Fraysse Defois-Fraysse, Caroline Decombat, Bertrand Evrard, et al.. Development of a post-biotic as a Therapeutic Support for Managing Obesity-Linked Psoriasis. SPIM: Skin Physiology International Meeting, Nov 2024, Vichy, France. hal-04875898

HAL Id: hal-04875898

https://hal.science/hal-04875898v1

Submitted on 13 Jan 2025

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Distributed under a Creative Commons Attribution 4.0 International License
# Development of a post-biotic as a Therapeutic Support for Managing Obesity-Linked Psoriasis

A. Chervet¹, R. Nehme¹, C. Defois-Fraysse², C. Decombat¹, B. Evrard¹, E. Filaire¹, J.-Y. Berthon³, A. Dreux- Zigha², L. Delort¹, A. F. Caldefie-Chezet¹

¹INRAE, UNH, Unité de Nutrition Humaine, UCA, Clermont-Ferrand, ²Greencell, Saint-Beauzire, France, ³Greentech, Saint-Beauzire, France

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Phytoprob'inoV

Labcom

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GREENTECH

BIOTECHNOLOGIES

ECREIN
microEnvironnement CelluleRE. Immunomodulation et Nutrition

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UNH

Unité de Nutrition Humaine

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UNIVERSITÉ
Clermont
Auvergne

INRAO

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aRT

ASSOCIATION NATIONALE
RECHERCHE TECHNOLOGIE

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L'EUROPE S'ENGAGE
en **r**egion
Auvergne-Rhône-Alpes
avec le FEDER

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I-SITE
CLERMONT
Clermont Auvergne Project

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## Background

Obesity, which has become a global public health issue, is defined by an excessive accumulation of body fat. It is a chronic disease and a major risk factor for many other pathologies development such as psoriasis. Obesity epidemiology demonstrates that its prevalence has gradually increased over the last few decades. According to WHO, more than 890 million persons are estimated to be obese in 2022.

## Objective

The aim of the project is to develop new natural health products for nutraceuticals and dermo-cosmetics. The extracts are obtained from the fermentation of a prebiotic and a probiotic. 37 combinations have been developed and investigated. Two of them have been retained for additional studies, including Phyto-Probiotics 31.

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Keratinocyte activation and clinical manifestations of psoriasis

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## Targets

Low-grade Inflammation

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Obesity

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Psoriasis

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## Methods & Results

### Leptin, adiponectin and HSL (hormone-sensitive lipase) expression on human mature adipospheroids

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### THP-1 polarisation into M0-like or M1-like macrophages

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### Psoriatic keratinocytes

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Reduced the gene expression of M1-like markers (TNF-α, IL-6, IL-8, IL-1β & CXCL10)

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Lowered the secretion of IL-6 & IL-1β, not significant for IL-8 and S100A7

S100A7 (psoriasin): bacteriocin up-regulated in patients with psoriasis

### Co-culture mature obese adipospheroids / psoriatic keratinocytes

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Decreased the secretion of IL-6, IL-8, IL-1β, S100A7

## Conclusion

PP31 extract may exhibit a triple effect by targeting obesity, inflammation, and psoriasis biomarkers, and may help in both local and systemic management of obesity-linked psoriasis

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