<table><caption>Table S10. Summary of the functional pathways found in the models, the number of pathways grouped on each meta-pathway and the percentage of pathways inside each meta-pathway considering the total number of pathways.</caption><thead><tr><th rowspan="2">Group of pathways</th><th colspan="2">Ts66Yah HIP</th><th colspan="2">Ts66Yah EC</th><th colspan="2">Ts65Dn HIP</th><th colspan="2">Ts65Dn EC</th></tr><tr><th>pathway s/ group</th><th>% pathways per group</th><th>nb total pathways per group</th><th>% pathways per group</th><th>nb total pathways per group</th><th>% pathways per group</th><th>nb total pathways per group</th><th>% pathways per group</th></tr></thead><tbody><tr><td>Synaptic</td><td>12</td><td>3,72</td><td>4</td><td>10</td><td>8</td><td>1,51</td><td>10</td><td>6,62</td></tr><tr><td>GABA system</td><td>1</td><td>0,31</td><td></td><td></td><td>1</td><td>0,19</td><td>5</td><td>3,31</td></tr><tr><td>Myelin sheat:SNARE complex</td><td></td><td></td><td></td><td></td><td>2</td><td>0,38</td><td></td><td></td></tr><tr><td>Behaviour</td><td>3</td><td>0,93</td><td></td><td></td><td>2</td><td>0,38</td><td>1</td><td>0,66</td></tr><tr><td>Synaptic: Other pathways</td><td>12</td><td>3,72</td><td>4</td><td>10</td><td>4</td><td>0,75</td><td>10</td><td>6,62</td></tr><tr><td>Transcription & epigenomic regulation</td><td>22</td><td>6,81</td><td>2</td><td>5</td><td>24</td><td>4,53</td><td>10</td><td>6,62</td></tr><tr><td>Enzymes activity</td><td>52</td><td>16,1</td><td></td><td></td><td>88</td><td>16,6</td><td>40</td><td>26,49</td></tr><tr><td>Mitochondria</td><td>1</td><td>0,31</td><td></td><td></td><td></td><td></td><td>5</td><td>3,31</td></tr><tr><td>Ribosome</td><td>3</td><td>0,93</td><td></td><td></td><td>6</td><td>1,13</td><td>4</td><td>2,65</td></tr><tr><td>Compounds binding</td><td>16</td><td>4,95</td><td>3</td><td>7,5</td><td>28</td><td>5,28</td><td>19</td><td>12,58</td></tr><tr><td>Cell Structure & organelles</td><td>12</td><td>3,72</td><td>7</td><td>17,5</td><td>82</td><td>15,47</td><td>40</td><td>26,49</td></tr><tr><td>Phospho-Kinase</td><td>8</td><td>2,48</td><td></td><td></td><td>8</td><td>1,51</td><td>3</td><td>1,99</td></tr><tr><td>Hormone regulation</td><td>4</td><td>1,24</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Post-translation modification</td><td>1</td><td>0,31</td><td></td><td></td><td>4</td><td>0,75</td><td></td><td></td></tr><tr><td>Replication</td><td>4</td><td>1,24</td><td>1</td><td>2,5</td><td>7</td><td>1,32</td><td></td><td></td></tr><tr><td>Morphogenesis & development</td><td>32</td><td>9,91</td><td>14</td><td>35</td><td>89</td><td>16,79</td><td>9</td><td>5,96</td></tr><tr><td>Host response & defense</td><td>127</td><td>39,32</td><td>2</td><td>5</td><td>174</td><td>32,83</td><td>18</td><td>11,92</td></tr><tr><td>Metabolism</td><td>67</td><td>20,74</td><td>9</td><td>22,5</td><td>118</td><td>22,26</td><td>33</td><td>21,85</td></tr><tr><td>Degradation system</td><td>1</td><td>0,31</td><td></td><td></td><td>7</td><td>1,32</td><td>7</td><td>4,64</td></tr><tr><td>Cardiovascular & homeostasis</td><td>16</td><td>4,95</td><td></td><td></td><td>19</td><td>3,58</td><td>4</td><td>2,65</td></tr><tr><td>Apoptosis & cell death</td><td>2</td><td>0,62</td><td></td><td></td><td>9</td><td>1,7</td><td></td><td></td></tr><tr><td>Connective-tissue cells</td><td></td><td></td><td>2</td><td>5</td><td>11</td><td>2,08</td><td>1</td><td>0,66</td></tr><tr><td>Fibers and cytoskeleton</td><td>5</td><td>1,55</td><td></td><td></td><td>5</td><td>0,94</td><td>18</td><td>11,92</td></tr><tr><td>Stimulus detection</td><td>2</td><td>0,62</td><td></td><td></td><td>4</td><td>0,75</td><td></td><td></td></tr><tr><td>Signaling pathways</td><td>14</td><td>4,33</td><td>2</td><td>5</td><td>30</td><td>5,66</td><td>6</td><td>3,97</td></tr></tbody></table>
<table><tr><td>Channels and location signals</td><td>55</td><td>17,03</td><td>81</td><td>15,28</td><td>14</td><td>9,27</td></tr><tr><td>Sexual development & embryogenesis</td><td>2</td><td>0,62</td><td></td><td></td><td>3</td><td>1,99</td></tr><tr><td>Aging</td><td></td><td>1</td><td>2,5</td><td></td><td></td><td></td></tr></table>

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