# Author Correction: Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

Carmen Noelker, Lydie Morel, Thomas Lescot, Anke Osterloh, Daniel Alvarez-Fischer, Minka Breloer, Carmen Henze, Candan Depboylu, Delphine Skrzydelski, Patrick P Michel, et al.

► To cite this version:

Carmen Noelker, Lydie Morel, Thomas Lescot, Anke Osterloh, Daniel Alvarez-Fischer, et al. Author Correction: Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease. Scientific Reports, 2023, 13 (1), pp.826. 10.1038/s41598-022-26917-1. hal-04785385

HAL Id: hal-04785385

https://hal.science/hal-04785385v1

Submitted on 15 Nov 2024

HAL is a multi-disciplinary open access
archive for the deposit and dissemination of sci-
entific research documents, whether they are pub-
lished or not. The documents may come from
teaching and research institutions in France or
abroad, or from public or private research centers.

L'archive ouverte pluridisciplinaire HAL, est
destinée au dépôt et à la diffusion de documents
scientifiques de niveau recherche, publiés ou non,
émanant des établissements d'enseignement et de
recherche français ou étrangers, des laboratoires
publics ou privés.

<figure><img src="image_1.png" /></figure>

Distributed under a Creative Commons Attribution 4.0 International License
<figure><img src="image_2.png" /></figure>

Check for updates

OPEN

# Author Correction: Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

Published online: 16 January 2023

Carmen Noelker, Lydie Morel, Thomas Lescot, Anke Osterloh, Daniel Alvarez-Fischer, Minka Breloer, Carmen Henze, Candan Depboylu, Delphine Skrzydelski, Patrick P. Michel, Richard C. Dodel, Lixia Lu, Etienne C. Hirsch, Stéphane Hunot & Andreas Hartmann

Correction to: *Scientific Reports* https://doi.org/10.1038/srep01393, published online 6 March 2013

This Article contains errors in Figures 1 and 2.

In Figure 1C, the two top panels and the two bottom panels are reversed. Additionally, the panel labels contain errors, where the left top panel label should read "TLR-deficient Control", the right top panel label should read "TLR-deficient MPTP" and the left bottom panel label should read "WT Control".

In Figure 2C, the panel labels contain errors, where the left top panel label should read "WT Control", the left bottom panel label should read "TLR-deficient Control" and the right bottom panel label should read "TLR-deficient MPTP".

The correct Figures 1 and 2 and accompanying legends appear below.
<figure><img src="image_3.png" /><figcaption>**Figure 1.** (A): HPLC measurement of striatal dopamine (DA) and homovanillic acid (HVA) levels, as well as calculation of the HVA/DA-ratio after MPTP-intoxication of TLR4-deficient (TLR def) and WT mice in comparison to saline treated mice. Values are expressed as mean ± SEM (\*p < 0.05 comparing MPTP treated group with its saline control, \*\*p < 0.05 comparing MPTP-treated groups of WT and TLR4-deficient mice.</figcaption></figure>

(B): TH-positive cell number in SN after MPTP treatment. WT = WT mice, TLR deficient = TLR4 deficient mice. Values are expressed as mean ± SEM (\*p < 0.05 comparing MPTP treated group with its saline control).

(C): Representative photographs of the SN of each treatment group is shown. TH-staining of free-floating cryomicrotome-cut sections at day 7. TLR4-deficient = TLR4-deficient mice, WT = wild-type mice. Control = saline treated mice, MPTP = MPTP-treated mice, Scale bars = 200 µm.
A

<figure><img src="image_4.png" /></figure>

C

<figure><img src="image_5.png" /></figure>

B

<figure><img src="image_6.png" /></figure>

D

<figure><img src="image_7.png" /></figure>

**Figure 2.** (A): Number of nigral Iba+ microglia at day 2 and day 7. WT = WT mice, TLR def = TLR4-deficient mice. Values are expressed as mean ± SEM (\*p < 0.05 comparing MPTP-treated group with its saline control, \*\*p < 0.05 comparing MPTP-treated groups of WT and TLR4-deficient mice). (B): MHC II+ cell number in SN after MPTP treatment at day 2. WT = WT mice, TLR def = TLR4-deficient mice. Values are expressed as mean ± SEM (\*p < 0.05 comparing MPTP-treated group with its saline control, \*\*p < 0.05 comparing MPTP-treated groups of WT and TLR4-deficient mice). (C): Representative photographs of the SN (Iba-1 staining) of each treatment group at day 2 are shown. TLR4 def = TLR4-deficient mice, WT = wild-type mice. Control = saline treated mice, MPTP = MPTP treated mice. Scale bars = 200 µm. (D): Correlation analysis of TH+ and Iba+ positive cells counts at day 7 in SNpc (r = -0.92, p < 0.001).

<figure><img src="image_8.png" /></figure>

**Open Access** This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

© The Author(s) 2023