# Rescue endoscopic treatment with completion by radical surgery following misplacement of a partially covered metal stent in an anastomotic fistula post-Lewis Santy esophagectomy.

Pierre Mayer, Lucile Héroin, Francois Habersetzer, Pierre-Yves Christmann, Jérôme Huppertz, Leonardo Sosa-Valencia, Abdenor Badaoui

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Pierre Mayer, Lucile Héroin, Francois Habersetzer, Pierre-Yves Christmann, Jérôme Huppertz, et al. Rescue endoscopic treatment with completion by radical surgery following misplacement of a partially covered metal stent in an anastomotic fistula post-Lewis Santy esophagectomy. Endoscopy, 2024, 56 (S 01), 10.1055/a-2371-0827. hal-04709857

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Submitted on 25 Sep 2024

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# Rescue endoscopic treatment with completion by radical surgery following misplacement of a partially covered metal stent in an anastomotic fistula post-Lewis Santy esophagectomy

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<figure><img src="image_3.png" /><figcaption>► **Fig. 1** Computed tomography images from the initial scan showing: a the partially covered self-expandable metal stent (PCSEMS; red star) within the esophageal lumen; b the PCSEMS passing into the mediastinal cavity through the anastomotic fistula; c the PCSEMS within the mediastinal cavity, with a fluid and air-containing collection in this area; d the distal flange of the stent (red circles) in contact with the thoracic drain (green arrow).</figcaption></figure>

Curative management of esophageal adenocarcinoma is based on esophagectomy. One of the main complications is anastomotic fistula (30%) [1], which is responsible for significant postoperative morbidity and mortality, as well as reduced survival [2]. In recent years, endoscopic treatment of anastomotic fistulas has become a valuable option, enabling closure of the fistula and a reduction in the mortality rate [3, 4].

We report the case of a 55-year-old patient who underwent a Lewis Santy esophagectomy for esophageal adenocarcinoma. The patient developed an anastomotic fistula with a pleural abscess requiring antibiotics, thoracic drainage, and placement of a partially covered self-expandable metal stent (PCSEMS) to cover the fistula. However, the thoracic drainage remained highly productive and an endoscopy revealed migration of the stent's distal flange, with em-

bedment into the fistula (► **Fig. 1** and ► **Fig. 2**). After several unsuccessful attempts at endoscopic removal, the patient was transferred to our center. He presented to us with a chronic pleural infection and total dependence on parenteral nutrition. An endoscopic procedure to re-establish digestive continuity was planned. The lower pole of the fibrin-wrapped stent and a productive fistulous orifice were identified (► **Fig. 3**). We managed to pass the scope in parallel to the stent to gain access to the gastroplasty. After a guidewire had been positioned in the gastroplasty, a fully covered metal stent (FCSEMS) was placed in parallel and successfully re-established digestive continuity and excluded the fistula (► **Video 1**).

The FCSEMS was removed after 3 months, but the PCSEMS remained irremovable. After discussion with the surgical team, it was decided to try the stent-in-stent

technique [5], and a new FCSEMS was inserted inside the PCSEMS (► **Fig. 4**). A further endoscopy was performed 2 weeks later, at which the FCSEMS was

<figure><img src="image_4.png" /><figcaption>► **Fig. 2** 3D reconstruction from the initial computed tomography scan showing that the stent has migrated into the mediastinal cavity through the anastomotic fistula orifice.</figcaption></figure>

<figure><img src="image_5.png" /><figcaption>► **Video 1** Endoscopic procedures are performed firstly to re-establish digestive continuity for optimal nutrition and the anastomotic fistula is excluded by placing a fully covered self-expandable metal stent alongside the partially covered self-expandable metal stent (PCSEMS) that had migrated into the anastomotic fistula; the stent-in-stent technique is subsequently attempted for extraction of the PCSEMS.</figcaption></figure>
<figure><img src="image_6.png" /><figcaption>► **Fig. 3** Endoscopic images from the first procedure performed in our center showing: a the fistulous orifice and incarceration of the distal flange of the partially covered self-expandable metal stent (PCSEMS); b the gastroplasty and passage of the PCSEMS through the fistulous orifice.</figcaption></figure>

<figure><img src="image_7.png" /><figcaption>► **Fig. 4** 3D reconstruction from the CT scan performed after placement of a fully covered self-expandable metal stent (FCSEMS) within the partially covered self-expandable metal stent (PCSEMS) for the stent-in-stent technique.</figcaption></figure>

removed without difficulty, but the PCSEMS remained embedded. Given the impossibility of endoscopic PCSEMS removal, it was decided that surgical management would be required and the patient underwent surgical removal of the PCSEMS and coloplasty.

Endoscopy_UCTN_Code_TTT_1AO_2AI

Conflict of Interest

The authors declare that they have no conflict of interest.

The authors

Pierre Mayer¹,², Lucile Héroin¹,², François Habersetzer¹,²,³, Pierre-Yves Christmann¹,², Jérôme Huppertz⁴,², Leonardo Sosa-Valencia⁵, Abdenor Badaoui⁶

1. Department of Gastroenterology and Hepatology, University Hospitals Strasbourg, Strasbourg, France

2. Digestive Endoscopy Unit, IHU Strasbourg, Strasbourg, France

3. Inserm U1110, Université de Strasbourg, Strasbourg, France

4. Department of Hepatogastroenterology, Clinique Sainte Barbe, Strasbourg, France

5. Research, IHU Strasbourg, Strasbourg, France

6. Department of Gastroenterology and Hepatology, CHU UCL Namur, Yvoir, Belgium

Corresponding author

Pierre Mayer, MD

Department of Gastroenterology and
Hepatology, Pôle des Pathologies
Hépatiques et Digestives, Nouvel Hôpital
Civil, Hôpitaux Universitaires de Strasbourg
(HUS), 1 place de l'Hôpital, 67000
Strasbourg, France
pierre-emmanuel.mayer@chru-strasbourg.fr

References

[1] Ubels S, Verstegen MHP, Klarenbeek BR et al. Treatment of anastomotic leak after oesophagectomy for oesophageal cancer: large, collaborative, observational TENTACLE cohort study. Br J Surg 2023; 110: 852–863. doi:10.1093/bjs/znad123

[2] Hagens ERC, Reijntjes MA, Anderegg MCJ et al. Risk factors and consequences of anastomotic leakage after esophagectomy for cancer. Ann Thorac Surg 2021; 112: 255–263. doi:10.1016/j.athoracsur.2020.08.022

[3] Spaander MCW, Baron TH, Siersema PD et al. Esophageal stenting for benign and malignant disease: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy 2016; 48: 939–948. doi:10.1055/s-0042-114210

[4] Gonzalez J-M, Servajean C, Aider B et al. Efficacy of the endoscopic management of postoperative fistulas of leakages after esophageal surgery for cancer: a retrospective series. Surg Endosc 2016; 30: 4895–4903. doi:10.1007/s00464-016-4828-7

[5] Hirdes MMC, Siersema PD, Houben MHMG et al. Stent-in-stent technique for removal of embedded esophageal self-expanding metal stents. Am J Gastroenterol 2011; 106: 286–293

Bibliography

Endoscopy 2024; 56: E716–E717

DOI 10.1055/a-2371-0827

ISSN 0013-726X

© 2024. The Author(s).

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