# Contrast-to-tissue ratio improvement by transmitted optimized binary signal in ultrasound pulse inversion imaging

Sébastien Ménigot, Jean-Marc Girault

► To cite this version:

Sébastien Ménigot, Jean-Marc Girault. Contrast-to-tissue ratio improvement by transmitted optimized binary signal in ultrasound pulse inversion imaging. 2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI), Apr 2013, San Francisco, United States. , pp.776 - 779, 2013, 10.1109/ISBI.2013.6556590 . hal-01075518

HAL Id: hal-01075518

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Submitted on 17 Oct 2014

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## 1. Introduction & Background

### A. Ultrasound Contrast Imaging

* Injection of encapsulated microbubbles

* High nonlinear behaviour

* Contrast-to-Tissue Ratio

$$CTR = \frac{E_{\text{microbubbles}}}{E_{\text{tissue}}}$$

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### B. Simulation

* Marmottant model for a 2.5 µm microbubble

* Nonlinear propagation in tissue by Anderson's model

* Transducer: 4 MHz - 75%

## 2. Pulse Inversion Ultrasound Imaging with Feedback

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Increasing *CTR* by odd harmonic extraction

## 3. Usual Transmitted Pulse

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## 4. Optimal Binary Command

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## 5. Optimization Process by Binary Genetic Algorithm

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## 6. Discussion

* Automatic optimization of CTR

* Gain

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* Stochastic excitation combined with genetic algorithm → Nonlinear

* Nonlinear backscattered components only due to medium nonlinearities

* Prospects

* Implementation on ultrasound scanner

* Using programmable analogue transmitter