# Investigating hippocampal synaptic plasticity in schizophrenia: A computational and experimental approach using MEA recordings

Sarah Hamdi Cherif, Candice Roux, Valentine Bouet, Jean-Marie Billard, Jérémie Gaidamour, Laure Buhry, Radu Ranta

► To cite this version:

Sarah Hamdi Cherif, Candice Roux, Valentine Bouet, Jean-Marie Billard, Jérémie Gaidamour, et al. Investigating hippocampal synaptic plasticity in schizophrenia: A computational and experimental approach using MEA recordings. Bernstein Conference, Sep 2024, Frankfurt, Germany. 2024, 10.12751/nncn.bc2024.244. hal-04835241

HAL Id: hal-04835241

https://hal.univ-lorraine.fr/hal-04835241v1

Submitted on 13 Dec 2024

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# Investigating hippocampal synaptic plasticity in Schizophrenia
## computational and experimental approach using MEA recordings

Sarah Hamdi Cherif, Candice Roux, Valentine Bouet, Jean-Marie Billard, Jérémie Gaidamour, Laure Buhry, Radu Ranta

*contact: sarah.hamdi-cherif@univ-Lorraine.fr
1. Université de Lorraine, CNRS, LORIA, France
2. Université de Lorraine, CNRS, CRAN, France
3. Université de Lorraine, CNRS, IECL, France
4. Normandie Univ, UNICAEN, CHU Caen,INSERM, CYCERON, COMETE, France

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## Conclusion

* These preliminary results show a functional data processing pipeline and visualisation tool to continue our study.

## Next steps

* Vary the experimentation (different protocols, stimulation zone and/or the stimulation characteristics)

* Validate the current results on more data

* Quantify plasticity and extract information that can be used in the computational model.

* Collect data from an SCZ animal model

[1]Howes O, et al. Glutamate and dopamine in schizophrenia: an update for the 21st century. J Psychopharmacol. 2015 Feb, 10.1177/0269881114563634
[2]Perclelay S, et al. Functional Dysregulations in CA1 Hippocampal Networks of a 3-Hit Mouse Model of Schizophrenia. International Journal of Molecular Sciences. 2021; 22(5):2644, 10.3390/ijms22052644
[3]Aussel A, et al. "Design of Experiments and Sobol' sensitivity analysis of a hippocampus computational model," 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Mexico, 2021, pp. 6146-6150, 10.1109/EMBC46164.2021.9630725
[4]Ranta R, et al. Reference estimation in EEG recordings. Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:5371-4., 10.1109/IEMBS.2010.5626488

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