# Measurements of the 161Tb production cross section for nuclear data and nuclear medicine

Arnaud Guertin, Etienne Nigron, Alexandre Rintaud, Maxence Rayer, Lucas

Granger, Thomas Sounalet, Ferid Haddad

► To cite this version:

Arnaud Guertin, Etienne Nigron, Alexandre Rintaud, Maxence Rayer, Lucas Granger, et al. Measurements of the 161Tb production cross section for nuclear data and nuclear medicine. Fourth International Conference on Advances in Radioactive Isotope Science (ARIS), Jun 2023, Avignon, France. pp.92/491, 10.5281/zenodo.10655037. hal-04521361

HAL Id: hal-04521361

https://hal.science/hal-04521361

Submitted on 26 Mar 2024

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<figure><img src="image_1.png" /></figure>

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# Measurements of the 161Tb production cross section for nuclear data and nuclear medicine

Arnaud Guertin, Etienne Nigron, Alexandre Rintaud, Maxence Rayer, Lucas

Granger, Thomas Sounalet, Ferid Haddad

► To cite this version:

Arnaud Guertin, Etienne Nigron, Alexandre Rintaud, Maxence Rayer, Lucas Granger, et al. Measurements of the 161Tb production cross section for nuclear data and nuclear medicine. Fourth International Conference on Advances in Radioactive Isotope Science (ARIS), Jun 2023, Avignon, France. pp.92/491, 10.5281/zenodo.10655037. hal-04521361

HAL Id: hal-04521361

https://hal.science/hal-04521361v1

Submitted on 26 Mar 2024

HAL is a multi-disciplinary open access
archive for the deposit and dissemination of sci-
entific research documents, whether they are pub-
lished or not. The documents may come from
teaching and research institutions in France or
abroad, or from public or private research centers.

L'archive ouverte pluridisciplinaire HAL, est
destinée au dépôt et à la diffusion de documents
scientifiques de niveau recherche, publiés ou non,
émanant des établissements d'enseignement et de
recherche français ou étrangers, des laboratoires
publics ou privés.

<figure><img src="image_1.png" /></figure>

Distributed under a Creative Commons Attribution 4.0 International License
The double Penning trap PIPERADE (Plèges de PEnning pour les RAdionucléides à DESIR) [1] for the DESIR facility has been advancing in its commissioning phase at the LP2i-Bordeaux laboratory. The traps were designed with the objective of performing high-precision mass measurements and high-resolution mass purification of strongly contaminated ion beams. The latter will be produced by the existing SPIRAL1 facility and the S3 spectrometer. In order to push the limits of existing devices, PIPERADE is equipped with a new type of high-capacity large trap that aims to separate up to $10^4 - 10^5$ ions per bunch.

The purified samples will be re-injected in the main DESIR beam line for downstream setups to perform trap-assisted spectroscopy. Alternatively, the purified samples will be utilized to perform high-precision mass measurements. In this context, standard ion-beam manipulation techniques are now being routinely demonstrated, i.e. the sideband buffer gas cooling (BGC) [2] and the time-of-flight ion-cyclotron-resonance (ToF-ICR) [3], while others are being implemented - phase-imaging ion-cyclotron-resonance (PI-ICR) [4]. Last year, as part of the implementation process of PI-ICR, an imaging system consisting of a microchannel-plate detector coupled to an anode constructed of helical wire delay lines was installed. RoentDek Handels GmbH has developed the delay-line anode with a specific three-layer geometry ("Hexanode") [5] to improve the ambiguity of multi-hit position and time encoding on the detector.

In this contribution, we will present the latest achievement from the BGC technique, the first mass measurement by using ToF-ICR and finally, the detector installation to allow the position encoding for future PI-ICR measurements.

[1] P. Ascher et al., Nucl. Instrum. Methods. Phys. Res. A 1019 (2021) 165857

[2] G. Savard, et al., Phys. Lett. A 158 (1991) 247

[3] M. Koenig, et al., Int. J. Mass Spectrom. 31 (1995) 95

[4] S. Eliseev et al., Phys. Rev. Lett. 110 082501 (2013)

[5] O. Jagutzki et al., IEEE Trans. Nuc. Sci. 49 (2002) 5

491

# Measurements of the 161Tb production cross section for nuclear data and nuclear medicine

**Auteurs:** Arnaud Guertin<fnref n="1" />; Etienne Nigron<fnref n="2" />

**Co-auteurs:** Alexandre Rintaud<fnref n="3" />; Maxence Rayer<fnref n="3" />; Lucas Granger<fnref n="3" />; Thomas Sounalet<fnref n="1" />; Férid Haddad<fnref n="4" />

**Auteur correspondant:** arnaud.guertin@subatech.in2p3.fr

161Tb has interesting physical properties for therapeutic applications in nuclear medicine. It has a half-life of 6.88 days and it is a β- emitter with a mean energy of 154 keV and a maximum energy between 42.85 and 593.1 keV. It corresponds to an electron range of 3 millimeters in water. Its coordination chemistry and energy range, comparable to that of 177Lu used in vectorized radiotherapy, allow a stable coordination with a DOTA chelator, a localized effect on targeted cells and limits the dose received by the surrounding healthy tissues. The therapeutic effect of 161Tb may be enhanced due to the co-emission of a larger number of conversion and Auger electrons as compared to 177Lu. In a theranostic approach, it could be coupled at another terbium isotope dedicated to diagnostic.

Production cross section of various β- and α emitters dedicated to therapy were measured by the PRISMA team of the Subatech laboratory at the GIP ARRONAX using a multiparticle C70XP cyclotron, the stacked-foil technique and gamma spectroscopy. From irradiated stacks, composed of natGd foils, Ni monitors and Al degraders, we are able to obtain the natGd(d,x)161Tb cumulative production cross section coming from the reactions 160Gd(d,p)161Gd and 160Gd(d,n)161Tb

<footnote n="1">¹ CNRS/IN2P3/SUBATECH</footnote>

<footnote n="2">² GIP ARRONAX</footnote>

<footnote n="3">³ SUBATECH</footnote>

<footnote n="4">⁴ SUBATECH, GIP ARRONAX</footnote>
The double Penning trap PIPERADE (Plèges de PEnning pour les RAdionucléides à DESIR) [1] for the DESIR facility has been advancing in its commissioning phase at the LP2i-Bordeaux laboratory. The traps were designed with the objective of performing high-precision mass measurements and high-resolution mass purification of strongly contaminated ion beams. The latter will be produced by the existing SPIRAL1 facility and the S3 spectrometer. In order to push the limits of existing devices, PIPERADE is equipped with a new type of high-capacity large trap that aims to separate up to $10^4 - 10^5$ ions per bunch.

The purified samples will be re-injected in the main DESIR beam line for downstream setups to perform trap-assisted spectroscopy. Alternatively, the purified samples will be utilized to perform high-precision mass measurements. In this context, standard ion-beam manipulation techniques are now being routinely demonstrated, i.e. the sideband buffer gas cooling (BGC) [2] and the time-of-flight ion-cyclotron-resonance (ToF-ICR) [3], while others are being implemented - phase-imaging ion-cyclotron-resonance (PI-ICR) [4]. Last year, as part of the implementation process of PI-ICR, an imaging system consisting of a microchannel-plate detector coupled to an anode constructed of helical wire delay lines was installed. RoentDek Handels GmbH has developed the delay-line anode with a specific three-layer geometry ( "Hexanode" ) [5] to improve the ambiguity of multi-hit position and time encoding on the detector.

In this contribution, we will present the latest achievement from the BGC technique, the first mass measurement by using ToF-ICR and finally, the detector installation to allow the position encoding for future PI-ICR measurements.

[1] P. Ascher et al., Nucl. Instrum. Methods. Phys. Res. A 1019 (2021) 165857

[2] G. Savard, et al., Phys. Lett. A 158 (1991) 247

[3] M. Koenig, et al., Int. J. Mass Spectrom. 31 (1995) 95

[4] S. Eliseev et al., Phys. Rev. Lett. 110 082501 (2013)

[5] O. Jagutzki et al., IEEE Trans. Nuc. Sci. 49 (2002) 5

491

# Measurements of the 161Tb production cross section for nuclear data and nuclear medicine

**Auteurs:** Arnaud Guertin<fnref n="1" />; Etienne Nigron<fnref n="2" />

**Co-auteurs:** Alexandre Rintaud<fnref n="3" />; Maxence Rayer<fnref n="3" />; Lucas Granger<fnref n="3" />; Thomas Sounalet<fnref n="1" />; Férid Haddad<fnref n="4" />

**Auteur correspondant** arnaud.guertin@subatech.in2p3.fr

161Tb has interesting physical properties for therapeutic applications in nuclear medicine. It has a half-life of 6.88 days and it is a β- emitter with a mean energy of 154 keV and a maximum energy between 42.85 and 593.1 keV. It corresponds to an electron range of 3 millimeters in water. Its coordination chemistry and energy range, comparable to that of 177Lu used in vectorized radiotherapy, allow a stable coordination with a DOTA chelator, a localized effect on targeted cells and limits the dose received by the surrounding healthy tissues. The therapeutic effect of 161Tb may be enhanced due to the co-emission of a larger number of conversion and Auger electrons as compared to 177Lu. In a theranostic approach, it could be coupled at another terbium isotope dedicated to diagnostic.

Production cross section of various β- and α emitters dedicated to therapy were measured by the PRISMA team of the Subatech laboratory at the GIP ARRONAX using a multiparticle C70XP cyclotron, the stacked-foil technique and gamma spectroscopy. From irradiated stacks, composed of natGd foils, Ni monitors and Al degraders, we are able to obtain the natGd(d,x)161Tb cumulative production cross section coming from the reactions 160Gd(d,p)161Gd and 160Gd(d,n)161Tb

<footnote n="1">¹ CNRS/IN2P3/SUBATECH</footnote>

<footnote n="2">² GIP ARRONAX</footnote>

<footnote n="3">³ SUBATECH</footnote>

<footnote n="4">⁴ SUBATECH, GIP ARRONAX</footnote>
between 6.69 and 16.47 MeV. Previous data sets published in the literature by Tarkanyi et al. [1] and Szelecsenyi et al. [2] are not in accordance, one objective of this work is to better define the shape and the maximum of the excitation function. Additional data have also been collected for the natGd(d,x)155Tb, 156Tb, 160Tb. Results are presented along with values extracted from TENDL-2019.

The only three series of published experimental data have been complemented in the energy region, near 12 MeV, of the maximum cross section, around 50 mb. This production cross section is of interest for nuclear models as it fixes the shape and the amplitude associated to this nuclear reaction and for nuclear medicine as it allows to defined optimized irradiation parameters to produce 161Tb that can be beneficial for vectorized radiotherapy to take advantage of its β- and Auger electron emissions.

[1] Tarkanyi, F., Hermanne, A., Tackacs, S., Ditroi, F. Csikai, J. & Ignatyuk, A. V. (2013). Cross-section measurement of some deuteron induced reactions on 160 Gd for possible production of the thera- peutic radionuclide 161 Tb. Journal of Radioanalytical and Nuclear Chemestry, 298(2), 1385-1392. https://doi.org/10.1007/s10967-013-2507-x

[2] Szelecsenyi, F., Kovacs, Z., Nagatsu, K., Zhang, M-R. & Suzuki, K. (2016). Investigation of deuteron-induced reactions on natGd up to 30 MeV: possibility of production of medically relevant 155Tb and 161Tb radioisotopes. Journal of Radioanalytical and Nuclear Chemestry, 307(3), 1877-1381. https://doi.org/10.1007/s10967-013-2507-x

plenary / 494

Latest results from MARA

Auteur: Juha Uusitalo<fnref n="1" /> for the nuclear spectroscopy group collaboration

¹ Accelerator Laboratory, Department of Physics, University of Jyväskylä

Auteur correspondant juha.uusitalo@jyu.fi

A new vacuum-mode separator, MARA (Mass Analyzing Recoil Apparatus) [1, 2], has been com-
pleted and has extended the research possibilities whit the existing gas-filled recoil separator, RITU
[3] at JYFL-ACCLAB. The ion-optical configuration of MARA is QQQDEDM, differing significantly
from the other existing in-flight separators around the world. MARA has turned out be a very
reliable separator and easy to operate. The studied nuclei of interest have been produced using
fusion-evaporation reactions, mainly employing symmetric or inverse kinematics. In-beam studies,
isomeric studies as well as production of new isotopes have been performed at and beyond the pro-
ton dripline starting from a mass number 66 up to a mass number 180. In this work some highlights
of the latest results using the JYFL in-flight separator MARA will be given.

[1] J. Uusitalo et al., Acta Physica Polonica B 50 (2019) 319

[2] J. Sarén et al., Research Report No. 7/2011, University of Jyväskylä

[3] M. Leino et al., NIMB 99 (1995), 653

parallel / 495

Isospin-symmetry breaking in the *B(E2)* transitions of *T* = 1
isotriplets

Auteurs: Betania Camille Tumelero Backes<fnref n="1" />; Michael Bentley<fnref n="1" />; Jacek Dobaczewski<fnref n="1" />; David Jenkins<fnref n="1" />; David Muir<fnref n="1" />; Witold Nazarewicz<fnref n="2" />; Paul-Gerhard Reinhard³; Robert Wadsworth<fnref n="1" />

<footnote n="1">¹ University of York</footnote>

<footnote n="2">² Michigan State University</footnote>
between 6.69 and 16.47 MeV. Previous data sets published in the literature by Tarkanyi et al. [1] and Szelecsenyi et al. [2] are not in accordance, one objective of this work is to better define the shape and the maximum of the excitation function. Additional data have also been collected for the natGd(d,x)155Tb, 156Tb, 160Tb. Results are presented along with values extracted from TENDL-2019.

The only three series of published experimental data have been complemented in the energy region, near 12 MeV, of the maximum cross section, around 50 mb. This production cross section is of interest for nuclear models as it fixes the shape and the amplitude associated to this nuclear reaction and for nuclear medicine as it allows to defined optimized irradiation parameters to produce 161Tb that can be beneficial for vectorized radiotherapy to take advantage of its β- and Auger electron emissions.

[1] Tarkanyi, F., Hermanne, A., Tackacs, S., Ditroi, F. Csikai, J. & Ignatyuk, A. V. (2013). Cross-section measurement of some deuteron induced reactions on 160 Gd for possible production of the therapeutic radionuclide 161 Tb. Journal of Radioanalytical and Nuclear Chemistry, 298(2), 1385-1392. https://doi.org/10.1007/s10967-013-2507-x

[2] Szelecsenyi, F., Kovacs, Z., Nagatsu, K., Zhang, M-R. & Suzuki, K. (2016). Investigation of deuteron-induced reactions on natGd up to 30 MeV: possibility of production of medically relevant 155Tb and 161Tb radioisotopes. Journal of Radioanalytical and Nuclear Chemistry, 307(3), 1877-1381. https://doi.org/10.1007/s10967-013-2507-x

plenary / 494

## Latest results from MARA

**Auteur:** Juha Uusitalo<fnref n="1" /> for the nuclear spectroscopy group collaboration

**Auteur correspondant:** juha.uusitalo@jyu.fi

A new vacuum-mode separator, MARA (Mass Analyzing Recoil Apparatus) [1, 2], has been completed and has extended the research possibilities whit the existing gas-filled recoil separator, RITU [3] at JYFL-ACCLAB. The ion-optical configuration of MARA is QQQDEDM, differing significantly from the other existing in-flight separators around the world. MARA has turned out be a very reliable separator and easy to operate. The studied nuclei of interest have been produced using fusion-evaporation reactions, mainly employing symmetric or inverse kinematics. In-beam studies, isomeric studies as well as production of new isotopes have been performed at and beyond the proton dripline starting from a mass number 66 up to a mass number 180. In this work some highlights of the latest results using the JYFL in-flight separator MARA will be given.

[1] J. Uusitalo et al., Acta Physica Polonica B 50 (2019) 319

[2] J. Sarén et al., Research Report No. 7/2011, University of Jyväskylä

[3] M. Leino et al., NIMB 99 (1995), 653

parallel / 495

## Isospin-symmetry breaking in the $B(E2)$ transitions of $T = 1$ isotriplets

**Auteurs:** Betania Camille Tumelero Backes<fnref n="1" />; Michael Bentley<fnref n="1" />; Jacek Dobaczewski<fnref n="1" />; David Jenkins<fnref n="1" />; David Muir<fnref n="1" />; Witold Nazarewicz<fnref n="2" />; Paul-Gerhard Reinhard³; Robert Wadsworth<fnref n="1" />

<footnote n="1">¹ Accelerator Laboratory, Department of Physics, University of Jyväskylä</footnote>

<footnote n="1">¹ University of York</footnote>

<footnote n="2">² Michigan State University</footnote>