Litinskiy, M.B., Nardelli, B., Hilbert, D.M., He, B., Schaffer, A., Casali, P., Cerutti, A., 2002. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat. Immunol. 3, 822–829.

Liu, F.-T., Newland, A.C., Jia, L., 2003. Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. Biochem. Biophys. Res. Commun. 310, 956–962.

Liu, J., Uematsu, H., Tsuchida, N., Ikeda, M.-A., 2011. Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol. Cancer 10, 95.

Lopes-Carvalho, T., Foote, J., Kearney, J.F., 2005. Marginal zone B cells in lymphocyte activation and regulation. Curr. Opin. Immunol. 17, 244–250.

Luppi, M., Grazia Ferrari, M., Bonaccorsi, G., Longo, G., Narni, F., Barozzi, P., Marasca, R., Mussini, C., Torelli, G., 1996. Hepatitis C virus infection in subsets of neoplastic lymphoproliferations not associated with cryoglobulinemia. Leukemia 10, 351–355.

Maarof, G., Bouchet-Delbos, L., Gary-Gouy, H., Durand-Gasselin, I., Krzysiek, R., Dalloul, A., 2010. Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells. Blood 115, 1718–1726.

Macallan, D.C., Wallace, D.L., Zhang, Y., Ghattas, H., Asquith, B., De Lara, C., Worth, A., Panayiotakopoulos, G., Griffin, G.E., Tough, D.F., Beverley, P.C.L., 2005. B-cell kinetics in humans: rapid turnover of peripheral blood memory cells. Blood 105, 3633–3640.

Macatonia, S.E., Doherty, T.M., Knight, S.C., O'Garra, A., 1993. Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production. J. Immunol. 150, 3755–3765.

MacLennan, I., Vinuesa, C., 2002. Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses. Immunity 17, 235–238.

MacLennan, I.C.M., Toellner, K.-M., Cunningham, A.F., Serre, K., Sze, D.M.-Y., Zúñiga, E., Cook, M.C., Vinuesa, C.G., 2003. Extrafollicular antibody responses. Immunol. Rev. 194, 8–18.

Madireddi, M.T., Dent, P., Fisher, P.B., 2000a. AP-1 and C/EBP transcription factors contribute to mda-7 gene promoter activity during human melanoma differentiation. J. Cell. Physiol. 185, 36–46.

Madireddi, M.T., Dent, P., Fisher, P.B., 2000b. Regulation of mda-7 gene expression during human melanoma differentiation. Oncogene 19, 1362–1368.

Madireddi, M.T., Su, Z.Z., Young, C.S., Goldstein, N.I., Fisher, P.B., 2000c. Mda-7, a novel melanoma differentiation associated gene with promise for cancer gene therapy. Adv. Exp. Med. Biol. 465, 239–261.

Manser, T., 2004. Textbook germinal centers? J. Immunol. 172, 3369–3375.

Manson, J.J., Mauri, C., Ehrenstein, M.R., 2005. Natural serum IgM maintains immunological homeostasis and prevents autoimmunity. Springer Semin. Immunopathol. 26, 425–432.

Mantovani, A., Bussolino, F., Dejana, E., 1992. Cytokine regulation of endothelial cell function. FASEB J. 6, 2591–2599.

Mantovani, A., Garlanda, C., Introna, M., Vecchi, A., 1998. Regulation of endothelial cell function by pro- and anti-inflammatory cytokines. Transplant. Proc. 30, 4239–4243.

Manz, R.A., Hauser, A.E., Hiepe, F., Radbruch, A., 2005. Maintenance of serum antibody levels. Annu. Rev. Immunol. 23, 367–386.

Manz, R.A., Radbruch, A., 2002. Plasma cells for a lifetime? Eur. J. Immunol. 32, 923–927.
Marti, G.E., Faguet, G., Bertin, P., Agee, J., Washington, G., Ruiz, S., Carter, P., Zenger, V., Vogt, R., Noguchi, P., 1992. CD20 and CD5 expression in B-chronic lymphocytic leukemia. Ann. N. Y. Acad. Sci. 651, 480-483.

Mathian, A., Gallegos, M., Pascual, V., Banchereau, J., Koutouzov, S., 2011. Interferon-α induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZB×NZW)F1 mice but not in BALB/c mice. Eur. J. Immunol. 41, 863-872.

Matoba, S., Kang, J.-G., Patino, W.D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P.J., Bunz, F., Hwang, P.M., 2006. p53 regulates mitochondrial respiration. Science 312, 1650-1653.

McHeyzer-Williams, L.J., Driver, D.J., McHeyzer-Williams, M.G., 2001. Germinal center reaction. Curr. Opin. Hematol. 8, 52-59.

McHeyzer-Williams, L.J., Malherbe, L.P., McHeyzer-Williams, M.G., 2006. Checkpoints in memory B-cell evolution. Immunol. Rev. 211, 255-268.

McHeyzer-Williams, L.J., McHeyzer-Williams, M.G., 2005a. Antigen-specific memory B cell development. Annu. Rev. Immunol. 23, 487-513.

McHeyzer-Williams, L.J., McHeyzer-Williams, M.G., 2005b. Antigen-specific memory B cell development. Annu. Rev. Immunol. 23, 487-513.

McHeyzer-Williams, M.G., 2003. B cells as effectors. Curr. Opin. Immunol. 15, 354-361.

McIntyre, T.M., Klinman, D.R., Rothman, P., Lugo, M., Dasch, J.R., Mond, J.J., Snapper, C.M., 1993. Transforming growth factor beta 1 selectivity stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells. J. Exp. Med. 177, 1031-1037.

Medina, F., Segundo, C., Campos-Caro, A., González-García, I., Brieva, J.A., 2002. The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression. Blood 99, 2154-2161.

Medvedovic, J., Ebert, A., Tagoh, H., Busslinger, M., 2011. Pax5: a master regulator of B cell development and leukemogenesis. Adv. Immunol. 111, 179-206.

Meffre, E., Wardemann, H., 2008. B-cell tolerance checkpoints in health and autoimmunity. Curr. Opin. Immunol. 20, 632-638.

Mendelson, K.G., Contois, L.R., Tevosian, S.G., Davis, R.J., Paulson, K.E., 1996. Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. Proc. Natl. Acad. Sci. U.S.A. 93, 12908-12913.

Messmer, B.T., Messmer, D., Allen, S.L., Kolitz, J.E., Kudalkar, P., Cesar, D., Murphy, E.J., Koduru, P., Ferrarini, M., Zupo, S., Cutrona, G., Damle, R.N., Wasil, T., Rai, K.R., Hellerstein, M.K., Chiorazzi, N., 2005. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J. Clin. Invest. 115, 755-764.

Messmer, U.K., Pfeilschifter, J., 2000. New insights into the mechanism for clearance of apoptotic cells. Bioessays 22, 878-881.

Mhashilkar, A.M., Schrock, R.D., Hindi, M., Liao, J., Sieger, K., Kourouma, F., Zou-Yang, X.H., Onishi, E., Takh, O., Vedvick, T.S., Fanger, G., Stewart, L., Watson, G.J., Snary, D., Fisher, P.B., Saeki, T., Roth, J.A., Ramesh, R., Chada, S., 2001. Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy. Mol. Med. 7, 271-282.

Miller, J.F., 1999. Discovering the origins of immunological competence. Annu. Rev. Immunol. 17, 1-17.

Miller, J.F., Mitchell, G.F., 1968. Cell to cell interaction in the immune response. I. Hemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes. J. Exp. Med. 128, 801-820.
Mitchell, G.C., Fillinger, J.L., Sittadjody, S., Avila, J.L., Burd, R., Limesand, K.H., 2010. IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter. Cell Death Dis 1, e50.

Mitchell, G.F., Miller, J.F., 1968. Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. J. Exp. Med. 128, 821-837.

Mitchison, N.A., 2004. T-cell-B-cell cooperation. Nat. Rev. Immunol. 4, 308-312.

Mitsiades, C.S., Mitsiades, N., Poulaki, V., Schlossman, R., Akiyama, M., Chauhan, D., Hideshima, T., Treon, S.P., Munshi, N.C., Richardson, P.G., Anderson, K.C., 2002. Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene 21, 5673-5683.

Miyasaka, M., Tanaka, T., 2004. Lymphocyte trafficking across high endothelial venules: dogmas and enigmas. Nat. Rev. Immunol. 4, 360-370.

Mizoguchi, C., Uehara, S., Akira, S., Takatsu, K., 1999. IL-5 induces IgG1 isotype switch recombination in mouse CD38-activated sIgD-positive B lymphocytes. J. Immunol. 162, 2812-2819.

Mond, J.J., Lees, A., Snapper, C.M., 1995. T cell-independent antigens type 2. Annu. Rev. Immunol. 13, 655-692.

Moore, K.W., Vieira, P., Fiorentino, D.F., Trounstine, M.L., Khan, T.A., Mosmann, T.R., 1990. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science 248, 1230-1234.

Moser, K., Tokoyoda, K., Radbruch, A., MacLennan, I., Manz, R.A., 2006. Stromal niches, plasma cell differentiation and survival. Curr. Opin. Immunol. 18, 265-270.

Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., Honjo, T., 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553-563.

Murray, P.J., Young, R.A., 1999. Increased antimycobacterial immunity in interleukin-10-deficient mice. Infect. Immun. 67, 3087-3095.

Murugaiyan, G., Mittal, A., Lopez-Diego, R., Maier, L.M., Anderson, D.E., Weiner, H.L., 2009. IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J. Immunol. 183, 2435-2443.

Nagalakshmi, M.L., Murphy, E., McClanahan, T., De Waal Malefyt, R., 2004. Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization. Int. Immunopharmacol. 4, 577-592.

Nagasawa, T., 2006. Microenvironmental niches in the bone marrow required for B-cell development. Nat. Rev. Immunol. 6, 107-116.

Nakano, K., Vousden, K.H., 2001. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7, 683-694.

Noguchi, M., Yi, H., Rosenblatt, H.M., Filipovich, A.H., Adelstein, S., Modi, W.S., McBride, O.W., Leonard, W.J., 2008. Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 73: 147-157. 1993. J. Immunol. 181, 5817-5827.

Nossal, G.J.V., 2002. One cell, one antibody: prelude and aftermath. Immunol. Rev. 185, 15-23.

Notarangelo, L.D., Lanzi, G., Peron, S., Durandy, A., 2006. Defects of class-switch recombination. J. Allergy Clin. Immunol. 117, 855-864.

Nückel, H., Rebmann, V., Dürig, J., Dührsen, U., Grosse-Wilde, H., 2005. HLA-G expression is associated with an unfavorable outcome and immunodeficiency in chronic lymphocytic leukemia. Blood 105, 1694-1698.
Nurieva, R.I., Chung, Y., Hwang, D., Yang, X.O., Kang, H.S., Ma, L., Wang, Y., Watowich, S.S., Jetten, A.M., Tian, Q., Dong, C., 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29, 138-149.

Nurieva, R.I., Chung, Y., Martinez, G.J., Yang, X.O., Tanaka, S., Matskevitch, T.D., Wang, Y.-H., Dong, C., 2009. Bcl6 mediates the development of T follicular helper cells. Science 325, 1001-1005.

O'Connor, B.P., Gleeson, M.W., Noelle, R.J., Erickson, L.D., 2003. The rise and fall of long-lived humoral immunity: terminal differentiation of plasma cells in health and disease. Immunol. Rev. 194, 61-76.

O'Garra, A., Stapleton, G., Dhar, V., Pearce, M., Schumacher, J., Rugo, H., Barbis, D., Stall, A., Cupp, J., Moore, K., 1990. Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10. Int. Immunol. 2, 821-832.

Obukhanych, T.V., Nussenzweig, M.C., 2006. T-independent type II immune responses generate memory B cells. J. Exp. Med. 203, 305-310.

Ohtsuka, T., Buchsbaum, D., Oliver, P., Makhija, S., Kimberly, R., Zhou, T., 2003. Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway. Oncogene 22, 2034-2044.

Okada, T., Cyster, J.G., 2006. B cell migration and interactions in the early phase of antibody responses. Curr. Opin. Immunol. 18, 278-285.

Okamura, S., Ng, C.C., Koyama, K., Takei, Y., Arakawa, H., Monden, M., Nakamura, Y., 1999. Identification of seven genes regulated by wild-type p53 in a colon cancer cell line carrying a well-controlled wild-type p53 expression system. Oncol. Res. 11, 281-285.

Ollila, J., Vihinen, M., 2005. B cells. Int. J. Biochem. Cell Biol. 37, 518-523.

Ooi, J.D., Phoon, R.K.S., Holdsworth, S.R., Kitching, A.R., 2009. IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. J. Am. Soc. Nephrol. 20, 980-989.

Opferman, J.T., Korsmeyer, S.J., 2003. Apoptosis in the development and maintenance of the immune system. Nat. Immunol. 4, 410-415.

Panayiotidis, P., Jones, D., Ganeshaguru, K., Foroni, L., Hoffbrand, A.V., 1996. Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. Br. J. Haematol. 92, 97-103.

Park, C.-S., Choi, Y.S., 2005. How do follicular dendritic cells interact intimately with B cells in the germinal centre? Immunology 114, 2-10.

Parrish-Novak, J., Xu, W., Brender, T., Yao, L., Jones, C., West, J., Brandt, C., Jelinek, L., Madden, K., McKernan, P.A., Foster, D.C., Jaspers, S., Chandrasekher, Y.A., 2002. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J. Biol. Chem. 277, 47517-47523.

Pataer, A., Vorburger, S.A., Barber, G.N., Chada, S., Mhashilkar, A.M., Zou-Yang, H., Stewart, A.L., Balachandran, S., Roth, J.A., Hunt, K.K., Swisher, S.G., 2002. Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Cancer Res. 62, 2239-2243.

Paus, D., Phan, T.G., Chan, T.D., Gardam, S., Basten, A., Brink, R., 2006. Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J. Exp. Med. 203, 1081-1091.
Pedersen, I.M., Kitada, S., Leoni, L.M., Zapata, J.M., Karras, J.G., Tsukada, N., Kipps, T.J., Choi, Y.S., Bennett, F., Reed, J.C., 2002. Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1. Blood 100, 1795-1801.

Péguet-Navarro, J., Moulon, C., Caux, C., Dalbiez-Gauthier, C., Banchereau, J., Schmitt, D., 1994. Interleukin-10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells. Eur. J. Immunol. 24, 884-891.

Pelanda, R., Torres, R.M., 2006. Receptor editing for better or for worse. Curr. Opin. Immunol. 18, 184-190.

Peng, S.L., 2005. Signaling in B cells via Toll-like receptors. Curr. Opin. Immunol. 17, 230-236.

Perez-Andres, M., Paiva, B., Nieto, W.G., Caraux, A., Schmitz, A., Almeida, J., Vogt, R.F., Jr, Marti, G.E., Rawstron, A.C., Van Zelm, M.C., Van Dongen, J.J.M., Johnsen, H.E., Klein, B., Orfao, A., 2010. Human peripheral blood B-cell compartments: a crossroad in B-cell traffic. Cytometry B Clin Cytom 78 Suppl 1, S47-60.

Peschke, T., Bender, A., Nain, M., Gemsa, D., 1993. Role of macrophage cytokines in influenza A virus infections. Immunobiology 189, 340-355.

Piqueras, B., Connolly, J., Freitas, H., Palucka, A.K., Banchereau, J., 2006. Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors. Blood 107, 2613-2618.

Poindexter, N.J., Walch, E.T., Chada, S., Grimm, E.A., 2005. Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells. J. Leukoc. Biol. 78, 745-752.

Preud'homme, J.L., Seligmann, M., 1972. Surface bound immunoglobulins as a cell marker in human lymphoproliferative diseases. Blood 40, 777-794.

Pulendran, B., Ahmed, R., 2006. Translating innate immunity into immunological memory: implications for vaccine development. Cell 124, 849-863.

Qi, H., Egen, J.G., Huang, A.Y.C., Germain, R.N., 2006. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312, 1672-1676.

Qiang, Y.-W., Kopantzev, E., Rudikoff, S., 2002. Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk. Blood 99, 4138-4146.

Rai, K.R., Sawitsky, A., Cronkite, E.P., Chanana, A.D., Levy, R.N., Pasternack, B.S., 1975. Clinical staging of chronic lymphocytic leukemia. Blood 46, 219-234.

Ramírez, J., Lukin, K., Hagman, J., 2010. From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment. Curr. Opin. Immunol. 22, 177-184.

Ranheim, E.A., Cantwell, M.J., Kipps, T.J., 1995. Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells. Blood 85, 3556-3565.

Raval, A., Tanner, S.M., Byrd, J.C., Angerman, E.B., Perko, J.D., Chen, S.-S., Hackanson, B., Grever, M.R., Lucas, D.M., Matkovic, J.J., Lin, T.S., Kipps, T.J., Murray, F., Weisenburger, D., Sanger, W., Lynch, J., Watson, P., Jansen, M., Yoshinaga, Y., Rosenquist, R., De Jong, P.J., Coggill, P., Beck, S., Lynch, H., De la Chapelle, A., Plass, C., 2007. Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell 129, 879-890.

Raveche, E.S., Salerno, E., Scaglione, B.J., Manohar, V., Abbasi, F., Lin, Y.-C., Fredrickson, T., Landgraf, P., Ramachandra, S., Huppi, K., Toro, J.R., Zenger, V.E., Metcalf, R.A., Marti, G.E., 2007. Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood 109, 5079-5086.
Rawstron, A., Hillmen, P., Houlston, R., 2004. Clonal lymphocytes in persons without known chronic lymphocytic leukemia (CLL): implications of recent findings in family members of CLL patients. Semin. Hematol. 41, 192-200.

Razanajaona, D., Van Kooten, C., Lebecque, S., Bridon, J.M., Ho, S., Smith, S., Callard, R., Banchereau, J., Brière, F., 1996. Somatic mutations in human Ig variable genes correlate with a partially functional CD40-ligand in the X-linked hyper-IgM syndrome. J. Immunol. 157, 1492-1498.

Redaelli, A., Laskin, B.L., Stephens, J.M., Botteman, M.F., Pashos, C.L., 2004. The clinical and epidemiological burden of chronic lymphocytic leukaemia. Eur J Cancer Care (Engl) 13, 279-287.

Reljic, R., Wagner, S.D., Peakman, L.J., Fearon, D.T., 2000. Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6. J. Exp. Med. 192, 1841-1848.

Renauld, J.-C., 2003. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators. Nat. Rev. Immunol. 3, 667-676.

Renshaw, B.R., Fanslow, W.C., 3rd, Armitage, R.J., Campbell, K.A., Liggitt, D., Wright, B., Davison, B.L., Maliszewski, C.R., 1994. Humoral immune responses in CD40 ligand-deficient mice. J. Exp. Med. 180, 1889-1900.

Riley, J.K., Takeda, K., Akira, S., Schreiber, R.D., 1999. Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action. J. Biol. Chem. 274, 16513-16521.

Roitt, I.M., Greaves, M.F., Torrigiani, G., Brostoff, J., Playfair, J.H., 1969. The cellular basis of immunological responses. A synthesis of some current views. Lancet 2, 367-371.

Rømer, J., Hasselager, E., Nørby, P.L., Steiniche, T., Thorn Clausen, J., Kragballe, K., 2003. Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol. J. Invest. Dermatol. 121, 1306-1311.

Rosenwald, A., Alizadeh, A.A., Widhopf, G., Simon, R., Davis, R.E., Yu, X., Yang, L., Pickeral, O.K., Rassenti, L.Z., Powell, J., Botstein, D., Byrd, J.C., Grever, M.R., Cheson, B.D., Chiorazzi, N., Wilson, W.H., Kipps, T.J., Brown, P.O., Staudt, L.M., 2001. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J. Exp. Med. 194, 1639-1647.

Rossi, E., Matutes, E., Morilla, R., Owusu-Ankomah, K., Heffernan, A.M., Catovsky, D., 1996. Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia. Leukemia 10, 494-497.

Saeki, T., Mhashilkar, A., Swanson, X., Zou-Yang, X.H., Sieger, K., Kawabe, S., Branch, C.D., Zumstein, L., Meyn, R.E., Roth, J.A., Chada, S., Ramesh, R., 2002. Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo. Oncogene 21, 4558-4566.

Sagaert, X., De Wolf-Peeters, C., 2003. Classification of B-cells according to their differentiation status, their micro-anatomical localisation and their developmental lineage. Immunol. Lett. 90, 179-186.

Sainz-Perez, A., Gary-Gouy, H., Gaudin, F., Maarof, G., Marfaing-Koka, A., De Revel, T., Dalloul, A., 2008. IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression. J. Immunol. 181, 6051-6060.

Sainz-Perez, A., Gary-Gouy, H., Portier, A., Davi, F., Merle-Beral, H., Galanaud, P., Dalloul, A., 2006. High Mda-7 expression promotes malignant cell survival and p38 MAP kinase activation in chronic lymphocytic leukemia. Leukemia 20, 498-504.
Salsano, F., Froland, S.S., Natvig, J.B., Michaelsen, T.E., 1974. Same idiotype of B-lymphocyte membrane IgD and IgM. Formal evidence for monoclonality of chronic lymphocytic leukemia cells. Scand. J. Immunol. 3, 841-846.

Sarkar, D., Su, Z., Lebedeva, I.V., Sauane, M., Gopalkrishnan, R.V., Dent, P., Fisher, P.B., 2002a. mda-7 (IL-24): signaling and functional roles. BioTechniques Suppl, 30-39.

Sarkar, D., Su, Z.-Z., Lebedeva, I.V., Sauane, M., Gopalkrishnan, R.V., Valerie, K., Dent, P., Fisher, P.B., 2002b. mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc. Natl. Acad. Sci. U.S.A. 99, 10054-10059.

Sauane, M., Gopalkrishnan, R.V., Lebedeva, I., Mei, M.X., Sarkar, D., Su, Z.-Z., Kang, D.-C., Dent, P., Pestka, S., Fisher, P.B., 2003a. Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways. J. Cell. Physiol. 196, 334-345.

Sauane, M., Gopalkrishnan, R.V., Sarkar, D., Su, Z.Z., Lebedeva, I.V., Dent, P., Pestka, S., Fisher, P.B., 2003b. MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine. Cytokine Growth Factor Rev. 14, 35-51.

Schaefer, G., Venkataraman, C., Schindler, U., 2001. Cutting edge: FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells. J. Immunol. 166, 5859-5863.

Scheeren, F.A., Naspetti, M., Diehl, S., Schotte, R., Nagasawa, M., Wijnands, E., Gimeno, R., Vyth-Dreese, F.A., Blom, B., Spits, H., 2005. STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression. Nat. Immunol. 6, 303-313.

Schimmer, A.D., Munk-Pedersen, I., Minden, M.D., Reed, J.C., 2003. Bcl-2 and apoptosis in chronic lymphocytic leukemia. Curr Treat Options Oncol 4, 211-218.

Schlesinger, M., Broman, I., Lugassy, G., 1996. The complement system is defective in chronic lymphatic leukemia patients and in their healthy relatives. Leukemia 10, 1509-1513.

Schneider, P., 2005. The role of APRIL and BAFF in lymphocyte activation. Curr. Opin. Immunol. 17, 282-289.

Schroer, K.R., Briles, D.E., Van Boxel, J.A., Davie, J.M., 1974. Idiotypic uniformity of cell surface immunoglobulin in chronic lymphocytic leukeima. Evidence for monoclonal proliferation. J. Exp. Med. 140, 1416-1420.

Sen, F., Lai, R., Albitar, M., 2002. Chronic lymphocytic leukemia with t(14;18) and trisomy 12. Arch. Pathol. Lab. Med. 126, 1543-1546.

Sewnath, M.E., Olszyna, D.P., Birjmohun, R., Ten Kate, F.J., Gouma, D.J., Van Der Poll, T., 2001. IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance. J. Immunol. 166, 6323-6331.

Shah, A.R., Maeda, K., Deegan, M.J., Roth, M.S., Schnitzer, B., 1992. A clinicopathologic study of familial chronic lymphocytic leukemia. Am. J. Clin. Pathol. 97, 184-188.

Shapiro-Shelef, M., Calame, K., 2005. Regulation of plasma-cell development. Nat. Rev. Immunol. 5, 230-242.

Shparago, N., Zelazowski, P., Jin, L., McIntyre, T.M., Stuber, E., Peçanha, L.M., Kehry, M.R., Mond, J.J., Max, E.E., Snapper, C.M., 1996. IL-10 selectively regulates murine Ig isotype switching. Int. Immunol. 8, 781-790.

Sims, G.P., Ettinger, R., Shirota, Y., Yarboro, C.H., Illei, G.G., Lipsky, P.E., 2005. Identification and characterization of circulating human transitional B cells. Blood 105, 4390-4398.
Siu, W.P., Pun, P.B.L., Latchoumycandane, C., Boelsterli, U.A., 2008. Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced hepatocyte injury: Multiple protective roles of cyclosporin A. Toxicol. Appl. Pharmacol. 227, 451-461.

Sjöberg, J., Aguilar-Santelises, M., Sjögren, A.M., Pisa, E.K., Ljungdahl, A., Björkholm, M., Jondal, M., Mellstedt, H., Pisa, P., 1996. Interleukin-10 mRNA expression in B-cell chronic lymphocytic leukaemia inversely correlates with progression of disease. Br. J. Haematol. 92, 393-400.

Slifka, M.K., Antia, R., Whitmire, J.K., Ahmed, R., 1998. Humoral immunity due to long-lived plasma cells. Immunity 8, 363-372.

Smith, M.L., Chen, I.T., Zhan, Q., Bae, I., Chen, C.Y., Gilmer, T.M., Kastan, M.B., O'Connor, P.M., Fornace, A.J., Jr, 1994. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 266, 1376-1380.

Song, H., Cerny, J., 2003. Functional heterogeneity of marginal zone B cells revealed by their ability to generate both early antibody-forming cells and germinal centers with hypermutation and memory in response to a T-dependent antigen. J. Exp. Med. 198, 1923-1935.

Soo, C., Shaw, W.W., Freymiller, E., Longaker, M.T., Bertolami, C.N., Chiu, R., Tieu, A., Ting, K., 1999. Cutaneous rat wounds express c49a, a novel gene with homology to the human melanoma differentiation associated gene, mda-7. J. Cell. Biochem. 74, 1-10.

Sozzani, S., Ghezzi, S., Iannolo, G., Luini, W., Borsatti, A., Polentarutti, N., Sica, A., Locati, M., Mackay, C., Wells, T.N., Biswas, P., Vicenzi, E., Poli, G., Mantovani, A., 1998. Interleukin 10 increases CCR5 expression and HIV infection in human monocytes. J. Exp. Med. 187, 439-444.

Spaner, D.E., Lee, E., Shi, Y., Wen, F., Li, Y., Tung, S., McCaw, L., Wong, K., Gary-Gouy, H., Dalloul, A., Ceddia, R., Gorzcynski, R., 2012. PPAR-alpha is a therapeutic target for chronic lymphocytic leukemia. Leukemia.

Sprenger, H., Meyer, R.G., Kaufmann, A., Bussfeld, D., Rischkowsky, E., Gemsa, D., 1996. Selective induction of monocyte and not neutrophil-attracting chemokines after influenza A virus infection. J. Exp. Med. 184, 1191-1196.

Srivastava, B., Lindsley, R.C., Nikbakht, N., Allman, D., 2005. Models for peripheral B cell development and homeostasis. Semin. Immunol. 17, 175-182.

Stavnezer, J., 2000. Molecular processes that regulate class switching. Curr. Top. Microbiol. Immunol. 245, 127-168.

Stein, J.V., Nombela-Arrieta, C., 2005. Chemokine control of lymphocyte trafficking: a general overview. Immunology 116, 1-12.

Stetson, D.B., Voehringer, D., Grogan, J.L., Xu, M., Reinhardt, R.L., Scheu, S., Kelly, B.L., Locksley, R.M., 2004. Th2 cells: orchestrating barrier immunity. Adv. Immunol. 83, 163-189.

Su, T.T., Guo, B., Wei, B., Braun, J., Rawlings, D.J., 2004. Signaling in transitional type 2 B cells is critical for peripheral B-cell development. Immunol. Rev. 197, 161-178.

Su, Z., Lebedeva, I.V., Gopalkrishnan, R.V., Goldstein, N.I., Stein, C.A., Reed, J.C., Dent, P., Fisher, P.B., 2001. A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells. Proc. Natl. Acad. Sci. U.S.A. 98, 10332-10337.

Su, Z.-Z., Lebedeva, I.V., Sarkar, D., Gopalkrishnan, R.V., Sauane, M., Sigmon, C., Yacoub, A., Valerie, K., Dent, P., Fisher, P.B., 2003. Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and
radiosensitization in malignant gliomas in a p53-independent manner. Oncogene 22, 1164-1180.

Sze, D.M., Toellner, K.M., García de Vinuesa, C., Taylor, D.R., MacLennan, I.C., 2000. Intrinsic constraint on plasmablast growth and extrinsic limits of plasma cell survival. J. Exp. Med. 192, 813-821.

Takayama, T., Morelli, A.E., Onai, N., Hirao, M., Matsushima, K., Tahara, H., Thomson, A.W., 2001. Mammalian and viral IL-10 enhance C-C chemokine receptor 5 but down-regulate C-C chemokine receptor 7 expression by myeloid dendritic cells: impact on chemotactic responses and in vivo homing ability. J. Immunol. 166, 7136-7143.

Tamura, K., Sawada, H., Izumi, Y., Fukuda, T., Utsunomiya, A., Ikeda, S., Uike, N., Tsukada, J., Kawano, F., Shibuya, T., Gondo, H., Okamura, S., Suzumiya, J., 2001. Chronic lymphocytic leukemia (CLL) is rare, but the proportion of T-CLL is high in Japan. Eur. J. Haematol. 67, 152-157.

Tangye, S.G., Hodgkin, P.D., 2004. Divide and conquer: the importance of cell division in regulating B-cell responses. Immunology 112, 509-520.

Tangye, S.G., Liu, Y.J., Aversa, G., Phillips, J.H., De Vries, J.E., 1998. Identification of functional human splenic memory B cells by expression of CD148 and CD27. J. Exp. Med. 188, 1691-1703.

Tonnelle, C., Dijon, M., Moreau, T., Garulli, C., Bardin, F., Chabannon, C., 2009. Stage specific over-expression of the dominant negative Ikaros 6 reveals distinct role of Ikaros throughout human B-cell differentiation. Mol. Immunol. 46, 1736-1743.

Tournoy, K.G., Kips, J.C., Pauwels, R.A., 2000. Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness. Clin. Exp. Allergy 30, 775-783.

Traggiai, E., Puzone, R., Lanzavecchia, A., 2003. Antigen dependent and independent mechanisms that sustain serum antibody levels. Vaccine 21 Suppl 2, S35-37.

Trinchieri, G., 2007. Interleukin-10 production by effector T cells: Th1 cells show self control. J. Exp. Med. 204, 239-243.

Tsuiji, M., Yurasov, S., Velinzon, K., Thomas, S., Nussenzweig, M.C., Wardemann, H., 2006. A checkpoint for autoreactivity in human IgM+ memory B cell development. J. Exp. Med. 203, 393-400.

Tsukada, N., Burger, J.A., Zvaifler, N.J., Kipps, T.J., 2002. Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia. Blood 99, 1030-1037.

Tussiwand, R., Bosco, N., Ceredig, R., Rolink, A.G., 2009. Tolerance checkpoints in B-cell development: Johnny B good. Eur. J. Immunol. 39, 2317-2324.

Vazquez-Torres, A., Jones-Carson, J., Wagner, R.D., Warner, T., Balish, E., 1999. Early resistance of interleukin-10 knockout mice to acute systemic candidiasis. Infect. Immun. 67, 670-674.

Veenstra, H., Jacobs, P., Dowdle, E.B., 1996. Abnormal association between invariant chain and HLA class II alpha and beta chains in chronic lymphocytic leukemia. Cell. Immunol. 171, 68-73.

Ventura, A., Kirsch, D.G., McLaughlin, M.E., Tuveson, D.A., Grimm, J., Lintault, L., Newman, J., Reczek, E.E., Weissleder, R., Jacks, T., 2007. Restoration of p53 function leads to tumour regression in vivo. Nature 445, 661-665.

Vilagos, B., Hoffmann, M., Souabni, A., Sun, Q., Werner, B., Medvedovic, J., Bilic, I., Minnich, M., Axelsson, E., Jaritz, M., Busslinger, M., 2012. Essential role of EBF1 in the generation and function of distinct mature B cell types. J. Exp. Med. 209, 775-792.
Vinuesa, C.G., Linterman, M.A., Goodnow, C.C., Randall, K.L., 2010. T cells and follicular dendritic cells in germinal center B-cell formation and selection. Immunol. Rev. 237, 72-89.

Vinuesa, C.G., Tangye, S.G., Moser, B., Mackay, C.R., 2005. Follicular B helper T cells in antibody responses and autoimmunity. Nat. Rev. Immunol. 5, 853-865.

Vogelzang, A., McGuire, H.M., Yu, D., Sprent, J., Mackay, C.R., King, C., 2008. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29, 127-137.

Vos, Q., Lees, A., Wu, Z.Q., Snapper, C.M., Mond, J.J., 2000. B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms. Immunol. Rev. 176, 154-170.

Wakkach, A., Fournier, N., Brun, V., Breittmayer, J.-P., Cottrez, F., Groux, H., 2003. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 18, 605-617.

Wallach, D., Kang, T.-B., Kovalenko, A., 2008. The extrinsic cell death pathway and the élan mortel. Cell Death Differ. 15, 1533-1541.

Wang, L., Du, F., Wang, X., 2008. TNF-alpha induces two distinct caspase-8 activation pathways. Cell 133, 693-703.

Wang, M., Liang, P., 2005. Interleukin-24 and its receptors. Immunology 114, 166-170.

Wang, M., Tan, Z., Zhang, R., Kotenko, S.V., Liang, P., 2002. Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. J. Biol. Chem. 277, 7341-7347.

Weintraub, A., 2003. Immunology of bacterial polysaccharide antigens. Carbohydr. Res. 338, 2539-2547.

Weller, S., Faili, A., Garcia, C., Braun, M.C., Le Deist F. F., De Saint Basile G., G., Hermine, O., Fischer, A., Reynaud, C.A., Weill, J.C., 2001. CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans. Proc. Natl. Acad. Sci. U.S.A. 98, 1166-1170.

Welsh, R.M., Selin, L.K., Szomolanyi-Tsuda, E., 2004. Immunological memory to viral infections. Annu. Rev. Immunol. 22, 711-743.

Wen, X.Y., Stewart, A.K., Sooknanan, R.R., Henderson, G., Hawley, T.S., Reimold, A.M., Glimcher, L.H., Baumann, H., Malek, L.T., Hawley, R.G., 1999. Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells. Int. J. Oncol. 15, 173-178.

Willems, F., Marchant, A., Delville, J.P., Gérard, C., Delvaux, A., Velu, T., De Boer, M., Goldman, M., 1994. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur. J. Immunol. 24, 1007-1009.

Winkelstein, A., Jordan, P.S., 1992. Immune deficiencies in chronic lymphocytic leukemia and multiple myeloma. Clin Rev Allergy 10, 39-58.

Wolk, K., Kunz, S., Asadullah, K., Sabat, R., 2002. Cutting edge: immune cells as sources and targets of the IL-10 family members? J. Immunol. 168, 5397-5402.

Wolk, K., Kunz, S., Witte, E., Friedrich, M., Asadullah, K., Sabat, R., 2004. IL-22 increases the innate immunity of tissues. Immunity 21, 241-254.

Wolniak, K.L., Shinall, S.M., Waldschmidt, T.J., 2004. The germinal center response. Crit. Rev. Immunol. 24, 39-65.

Xie, M.H., Aggarwal, S., Ho, W.H., Foster, J., Zhang, Z., Stinson, J., Wood, W.I., Goddard, A.D., Gurney, A.L., 2000. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J. Biol. Chem. 275, 31335-31339.
Yang, X., Gartner, J., Zhu, L., Wang, S., Brunham, R.C., 1999. IL-10 gene knockout mice show enhanced Th1-like protective immunity and absent granuloma formation following Chlamydia trachomatis lung infection. J. Immunol. 162, 1010-1017.

Yoshida, T., Ng, S.Y.-M., Zuniga-Pflucker, J.C., Georgopoulos, K., 2006. Early hematopoietic lineage restrictions directed by Ikaros. Nat. Immunol. 7, 382-391.

Yuan, J., Kroemer, G., 2010. Alternative cell death mechanisms in development and beyond. Genes Dev. 24, 2592-2602.

Yuille, M.R., Matutes, E., Marossy, A., Hilditch, B., Catovsky, D., Houlston, R.S., 2000. Familial chronic lymphocytic leukaemia: a survey and review of published studies. Br. J. Haematol. 109, 794-799.

Yurasov, S., Hammersen, J., Tiller, T., Tsuiji, M., Wardemann, H., 2005. B-cell tolerance checkpoints in healthy humans and patients with systemic lupus erythematosus. Ann. N. Y. Acad. Sci. 1062, 165-174.

Zapf, J., Hauri, C., Waldvogel, M., Futo, E., Häsler, H., Binz, K., Guler, H.P., Schmid, C., Froesch, E.R., 1989. Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats. Proc. Natl. Acad. Sci. U.S.A. 86, 3813-3817.

Zhan, Q., Fan, S., Bae, I., Guillouf, C., Liebermann, D.A., O'Connor, P.M., Fornace, A.J., Jr, 1994. Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene 9, 3743-3751.

Zhang, R., Tan, Z., Liang, P., 2000. Identification of a novel ligand-receptor pair constitutively activated by ras oncogenes. J. Biol. Chem. 275, 24436-24443.