OBJECTIVES: Pancreatic cancer (PC) is the fourth and fifth most common cause of cancer-related death among men in United States and in Europe, respectively. No data are available for HIV-positive patients. The aim of this study was to investigate and to compare clinical presentation and outcome between HIV-positive and HIV-negative PC patients. METHODS: From April 1988 to June 2010, the Italian Cooperative Group on AIDS and Tumors identified 16 cases of HIV-positive PC patients. Each HIV-positive patient from our institution was randomly matched (ratio 1:2) with HIV-negative patients (32 controls) based on sex and year of PC diagnosis. Differences in clinical presentation, treatment, and overall survival were assessed. RESULTS: At multivariate analysis, HIV-positive patients compared with HIV-negative patients had a higher risk of an unfavorable performance status (PS ≥2) and a younger age (<50 years) at cancer diagnosis. At multivariate analysis, HIV-positive status and PS of 2 or greater were the only 2 features that significantly reduced PC patients' survival. CONCLUSIONS: Our data show, for the first time, that HIV-positive PC patients, compared with HIV-negative patients, are younger at cancer diagnosis. Furthermore, they share a more unfavorable PS and a shorter survival.

Pancreatic Cancer in HIV-Positive Patients: A Clinical Case-Control Study / Zanet, E.; Berretta, M.; Di Benedetto, Fabrizio; Talamini, R.; Ballarin, Roberto; Nunnari, G.; Berretta, S.; Ridolfo, A.; Lleshi, A.; Zanghì, A.; Cappellani, A.; Tirelli, U.. - In: PANCREAS. - ISSN 0885-3177. - STAMPA. - 41:8(2012), pp. 1331-1335. [10.1097/MPA.0b013e31824a0e40]

### Pancreatic Cancer in HIV-Positive Patients: A Clinical Case-Control Study.

### Zanet, E.;Berretta, M.;DI BENEDETTO, Fabrizio;Talamini, R.;BALLARIN, Roberto;Nunnari, G.;Berretta, S.;Ridolfo, A.;Lleshi, A.;Zanghì, A.;Cappellani, A.;Tirelli, U.

### 2012

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