# V(D)J Recombination

National Cancer Institute

## Source

National Cancer Institute. [V(D)J Recombination](https://nci-thesaurus code C20971).

Any process of gene rearrangement in which the original variable and joining region coding segments of the immunoglobulin and T cell receptor genes are ligated to create a novel protein-coding capacity. This process may occur with inclusion of the diversity coding segment to create a V(D)J coding gene. V(D)J recombination is involved in generation of diversity for both antibody and T cell receptor responses.