Neuroimaging Highlight

Ventral Spinal Epidural Venous Pouch in Spinal Epidural Venous Fistula

Anish Kapadia<fnref n="1" />,² ID, Pejman Maralani<fnref n="1" />,², Farhad Pirouzmand³ and Leodante da Costa³ ID

**Keywords:** Spinal epidural arteriovenous fistula; Spinal dural arteriovenous fistula

(Received 4 October 2021; final revisions submitted 24 November 2021; date of acceptance 19 December 2021; First Published online 3 January 2022)

An 80-year-old male presented with a 3-month history of progressive right leg weakness and bilateral lower limb pares- thesias. Examination at presentation showed right leg weakness (3/5 hip flexors, 4/5 knee extension, 4/5 foot dorsiflexion, and 4/5 foot plantar flexion), no bowel, or bladder dysfunction. An MRI of the spine demonstrated spinal cord edema extending from the mid-thoracic region to the conus, with serpiginous flow voids surrounding the lower cord and conus suggestive of a spinal dural arteriovenous fistula (SDAVF; Figure 1A). Time-resolved MRA was initially performed which suggested a SDAVF at the right L2 level (Figure 1B). At angiography, this level could not be catheterized due to focal aortic ectasia, and the SDAVF could not be identified. He underwent attempted sur- gical disconnection based on the MRI findings. Subsequent high- resolution MRA of the spine demonstrated a small venous pouch in the anterolateral epidural space at the right L3 level with persis- tent shunting to enlarged peri-medullary veins (Figure 1C). Diagnostic spinal angiogram was performed which demonstrated a spinal epidural arteriovenous fistula (SEAVF) with arterial supply from the right L2 and L3 segmental arteries, a large anterior epidural venous pouch and shunting to the perimedullary veins via a promi- nent radicular vein (Figure 1D/E). Decision was made for endovas- cular embolization given the difficulties encountered with finding such fistulae on open surgical approach. Embolization was performed

from the right L3 segmental level with Squid 12 EVOH copolymer liquid embolic (Balt Extrusion, Montmorency, France). Penetration of the fistula network including the epidural pouch was achieved, as well as the distal aspect of the L2 segmental artery via reflux. Subsequent angiographic runs demonstrated no persistent fistula. Follow-up unenhanced CT demonstrates the liquid embolic cast highlighting the SEAVF anatomy (Figure 1F). The patient was dis- charged without complication.

SEAVF is a rare spinal shunt which often presents with perime- dullary venous drainage. These lesions are often misdiagnosed, as highlighted by this case, as spinal SDAVF.<fnref n="1" />,² One study found the rate of misdiagnosis for this entity as high as 70.8 % of cases.² Imaging criteria have been proposed to differentiate the two shunt types.<fnref n="1" />,³ SEAVF are typically seen in older males in the thoracic/lum- bar region with shunting seen to an epidural venous pouch within the ventral epidural space and subsequent drainage into perimedul- lary veins, paravertebral veins, or both.<fnref n="1" /> Although previously thought to demonstrate lower incidence of spinal venous reflux, more recent work suggests that spinal venous drainage is common resulting a presentation with myelopathy.<fnref n="1" />,⁴ Endovascular treatment has been the mainstay for these lesions due to the difficulties encountered with microsurgical approach.² However, a recent multicentre study from Japan demonstrated superiority of micro- surgical management with lower risk of treatment failure.⁵

**Corresponding author:** Anish Kapadia, Department of Medical Imaging, Sunnybrook Health Science Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada.
Email: Anish.kapadia@mail.utoronto.ca

**Cite this article:** Kapadia A, Maralani P, Pirouzmand F, and da Costa L. (2023) Ventral Spinal Epidural Venous Pouch in Spinal Epidural Venous Fistula. *The Canadian Journal of Neurological Sciences* **50**: 297-298, https://doi.org/10.1017/cjn.2021.516

<footnote n="1">¹Department of Medical Imaging, Sunnybrook Health Science Centre, Toronto, Ontario, Canada, ²Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada and ³Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada</footnote>
<figure><img src="image_1.png" /><figcaption>**Figure. 1.** Sagittal T2 images (A) of the lumbar spine demonstrates lower cord and conus edema. Time resolved MRA (B) suggests a possible spinal dural arteriovenous fistula at the right L2 level (white elbow arrow). Post-surgery high resolution MRA (C) demonstrates a persistent fistula, and a small ventral venous pouch is seen at the right L3 level (white arrow head) with a vein coursing towards to conus (white short arrows), suggesting the presence of a spinal epidural arteriovenous fistula (SEAVF). Repeat angiography (D,E) demonstrates a SEAVF with a ventral venous pouch at the right L3 level with arterial supply from the right segmental L3 (and L2) segmental arteries, and shunting to peri-medullary veins. Post-embolization CT (F), shows the cast of the liquid embolic highlighting the disconnected fistula(white arrow) with the epidural venous pouch.</figcaption></figure>

As management of these uncommon lesions evolve, it is imperative that the characteristic features of SEAVF are recognized and the correct diagnosis is made. The present case exquisitely highlights the characteristic anatomy of SEAVF with a prominent ventral epidural venous pouch and perimedullary venous shunting. In addition, the results of the endovascular treatment are shown with a liquid embolic cast of the fistula that is beautifully seen on subsequent CT.

**Acknowledgements.** None.

**Disclosures.** The authors do not have any conflicts related to this manuscript.

**Statement of Authorship.** Clinical management: AK, FP, PM, LD
Manuscript preparation: AK
Manuscript review, revisions and approval: AK, FP, PM, LD

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