# The Life-Functions Ratio: a new indicator trait of trade-offs to go beyond genetic correlations

Nicolas Bédère, Olivia Cado, Nicolas N.C. Friggens, Pascale Le Roy

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## To cite this version:

Nicolas Bédère, Olivia Cado, Nicolas N.C. Friggens, Pascale Le Roy. The Life-Functions Ratio: a new indicator trait of trade-offs to go beyond genetic correlations. 74. Annual meeting of the european federation of animal science (EAAP), EAAP, Aug 2023, Lyon, France. pp.784. hal-04192066

HAL Id: hal-04192066

https://hal.inrae.fr/hal-04192066

Submitted on 31 Aug 2023

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# The Life-Functions Ratio: a new indicator trait of trade-offs to go beyond genetic correlations

N. BEDERE¹, O. CADO¹, N. C. FRIGGENS², P. LE ROY¹

1. PEGASE, INRAE, Institut Agro, 35590, Saint-Gilles, France

2. Université Paris-Saclay, INRAE, AgroParisTech, UMR Modélisation Systémique Appliquée aux Ruminants, 91120, Palaiseau, France

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RÉPUBLIQUE
FRANÇAISE

Liberté
Egalité
Fraternité

INRAE
> Animals need to cope with environmental perturbations

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> Acting on tradeoffs to improve robustness

A way to look at environmental sensitivity = Robustness:

**multi-performance** in **multiple environments**

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Adapted from Friggens et al. (2017)

→ Genetic improvement of multi-performance:

- selection index

- global criterion (e.g. functional longevity)

- tradeoff
> What is a tradeoff?

Difficult question! Depends a lot on the scale (cell to regions) and on the field (genetics to economics).
A collective expertise in INRAE (Network Compromis, Metaprogram SANBA) confirmed.

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> Tradeoff and resource acquisition and allocation

Difficult question! Depends a lot on the scale (cell to regions) and on the field (genetics to economics).
A collective expertise in INRAE (Network Compromis, Metaprogram SANBA) confirmed.

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the "Y-model"
(van Noordwijk and de Jong, 1986)
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Questions !

AND

Answers ?

What is the genetic architecture of tradeoff between eggs and body reserves?

* Genetic parameters
  $h^2 = 0.31$

* QTL detection
  We identified 3 QTLs

What is the genetic relationship between tradeoff, allocation, and the original traits?

LFR was highly correlated with original traits ($r_g > 0.60$)

LFR was little correlated with $\alpha$ ($r_g = 0.02$)
> Materials

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Rhode Island line of Novogen (Nucleus + experimental supplement):

* 3 related batches from 2020 to 2022 (n=2,016 hens)

* Genotyped with a 60k SNP bedchip

* Phenotypes recorded (80 wks of age):

* Egg Number

* Backfat thickness (ultrasonography)

* Phenotype calculated : LFR

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> Methods

Variance components estimation with ASREML 4.2:

* Fixed effect of the batch

* Random effects: additive genetic effect (pedigree relationship matrix) and residuals

GWAS with Muller:

Same model with:

* BLUP (fixed additive genetic variance)

* Additional fixed effect: SNP (regression)

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## Genetic parameters

<table><thead><tr><th></th><th>α</th><th>LFR</th><th>Backfat</th><th>Eggs</th></tr></thead><tbody><tr><th>α</th><td>0.18 (0.05)</td><td></td><td></td><td></td></tr><tr><th>LFR</th><td>-0.02 (0.20)</td><td>0.31 (0.07)</td><td></td><td></td></tr><tr><th>Backfat</th><td>-0.63 (0.13)</td><td>0.78 (0.07)</td><td>0.44 (0.07)</td><td></td></tr><tr><th>Eggs</th><td>0.59 (0.13)</td><td>0.62 (0.11)</td><td>0.12 (0.18)</td><td>0.13 (0.04)</td></tr></tbody></table>

LFR displayed:

* Moderate heritability → room for genetic improvement

* Highly correlated with backfat and eggs → good tradeoff trait

* Not correlated with allocation coefficient → LFR and α relate to different aspects of tradeoff

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# Genome Wide Association Study

Carbohydrate sulfotransferase 10

energy metabolism
oestrogens

Long non coding RNA

RAN bind protein 3

energy metabolism

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Thanks for your attention

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**What is the genetic architecture of tradeoff between eggs and body reserves?**

- Moderate heritability (0.31) → room for genetic improvement

- Highly correlated with backfat and eggs → good tradeoff trait

**What is the genetic relationship between tradeoff, allocation, and the original traits?**

- Not correlated with allocation coefficient → LFR and α relate to different aspects of tradeoff

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