# Gene Rearrangement

National Cancer Institute

## Source

National Cancer Institute. Gene Rearrangement. NCI Thesaurus. Code C16611.

Any DNA sequence rearrangement that results in the creation of a novel protein-coding capacity. Within certain genes, gene rearrangement is a normal part of development, facilitating the affinity maturation of B and T lymphocytes as well as class switching of immunoglobulins.