Riviere, J. E., Gabrielsson, J., Fink, M., & Mochel, J. (2016). Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics. *Journal of Veterinary Pharmacology and Therapeutics*, 39(3), 213-223. https://doi.org/10.1111/jvp.12278

Rizzo, L., Manaia, C., Merlin, C., Schwartz, T., Dagot, C., Ploy, M. C., ... Fatta-Kassinos, D. (2013). Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: A review. *The Science of the Total Environment*, 447, 345-360. https://doi.org/10.1016/j.scitotenv.2013.01.032

Roach, R. W., & Hignett, S. L. (1945). Chemotherapy in the treatment of chronic contagious mastitis—II. *The Veterinary Journal* (1900), 101(5), 99-108. https://doi.org/10.1016/S0372-5545(17)32152-1

Roberts, S. J., & Kiesel, G. K. (1948). Treatment of pneumonia in cattle. *Journal of the American Veterinary Medical Association*, 112(850), 34-39.

Roselli, M., Finamore, A., Britti, M. S., Bosi, P., Oswald, I., & Mengheri, E. (2005). Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results. *Animal Research*, 54(3), 203-218. https://doi.org/10.1051/animres:2005012

Rutten, C. J., Velthuis, A. G. J., Steeneveld, W., & Hogeveen, H. (2013). Invited review: Sensors to support health management on dairy farms. *Journal of Dairy Science*, 96(4), 1928-1952. https://doi.org/10.3168/jds.2012-6107

Salter, R. S., Douglas, D., McRobbie, L., Quintana, J., Legg, D., Schwartz, J., ... Markovsky, R. (2011). Validation of the charm 3 SL3 beta-lactam test for screening raw milk in compliance with the U.S. pasteurized milk ordinance. Performance Tested Method 071002. *Journal of AOAC International*, 94(1), 348-357.

Sanders, P. (2000). Editorial. *International Journal of Antimicrobial Agents*, 14(4), 269-270. https://doi.org/10.1016/S0924-8579(00)00134-5

Sanders, P., Henri, J., & Laurentie, M. (2016). Tools to evaluate pharmacokinetics data for establishing maximum residue limits for approved veterinary drugs: Examples from JECFA's work. *Drug Testing and Analysis*, 8(5-6), 565-571. https://doi.org/10.1002/dta.2006

Scheidy, S. F. (1951). Antibiotic therapy in veterinary medicine. *Journal of the American Veterinary Medical Association*, 118(889), 213-220.

Schrijver, R., Stijntjes, M., Rodríguez-Baño, J., Tacconelli, E., Babu Rajendran, N., & Voss, A. (2018). Review of antimicrobial resistance surveillance programmes in livestock and meat in EU with focus on humans. *Clinical Microbiology and Infection: the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases*, 24(6), 577-590. https://doi.org/10.1016/j.cmi.2017.09.013

Schwarz, S., Enne, V. I., & van Duijkeren, E. (2016). 40 years of veterinary papers in JAC - what have we learnt? *Journal of Antimicrobial Chemotherapy*, 71(10), 2681-2690. https://doi.org/10.1093/jac/dkw363

Scott, A. M., Beller, E., Glasziou, P., Clark, J., Ranakusuma, R. W., Byambasuren, O., ... Mar, C. D. (2018). Is antimicrobial administration to food animals a direct threat to human health? A rapid systematic review. *International Journal of Antimicrobial Agents*, 52(3), 316-323. https://doi.org/10.1016/j.ijantimicag.2018.04.005

Shallcross, L. J., & Davies, S. C. (2014). The World Health Assembly resolution on antimicrobial resistance. *Journal of Antimicrobial Chemotherapy*, 69(11), 2883-2885. https://doi.org/10.1093/jac/dku346

Shryock, T. R. (2004). The future of anti-infective products in animal health. *Nature Reviews Microbiology*, 2(5), 425-430. https://doi.org/10.1038/nrmicro887

Silbergeld, E. K., Graham, J., & Price, L. B. (2008). Industrial food animal production, antimicrobial resistance, and human health. *Annual Review of Public Health*, 29(1), 151-169. https://doi.org/10.1146/annurev.publhealth.29.020907.090904

Singer, A. C., Shaw, H., Rhodes, V., & Hart, A. (2016). Review of antimicrobial resistance in the environment and its relevance to environmental regulators. *Frontiers in Microbiology*, 7, 1728. https://doi.org/10.3389/fmicb.2016.01728

Sisodia, C. S., & Stowe, C. M. (1964). The mechanism of drug secretion into bovine milk. *Annals of the New York Academy of Sciences*, 111, 650-661. https://doi.org/10.1111/j.1749-6632.1964.tb53133.x

Smith, H. W. (1968). Anti-microbial drugs in animal feeds. *Nature*, 218(5143), 728-731.

Smith, H. W. (1969). Transfer of antibiotic resistance from animal and human strains of Escherichia coli to resident E. coli in the alimentary tract of man. *Lancet* (London, England), 1(7607), 1174-1176.

Smith, H. W. (1970). The transfer of antibiotic resistance between strains of enterobacteria in chicken, calves and pigs. *Journal of Medical Microbiology*, 3(1), 165-180. https://doi.org/10.1099/00222615-3-1-165

Smith, H. W. (1971). The effect of the use of antibacterial drugs on the emergence of drug-resistant bacteria in animals. *Advances in Veterinary Science and Comparative Medicine*, 15, 67-100.

Stegemann, M. R., Sherington, J., & Blanchflower, S. (2006). Pharmacokinetics and pharmacodynamics of cefovecin in dogs. *Journal of Veterinary Pharmacology and Therapeutics*, 29(6), 501-511. https://doi.org/10.1111/j.1365-2885.2006.00801.x

Stegemann, M. R., Sherington, J., Coati, N., Brown, S. A., & Blanchflower, S. (2006). Pharmacokinetics of cefovecin in cats. *Journal of Veterinary Pharmacology and Therapeutics*, 29(6), 513-524. https://doi.org/10.1111/j.1365-2885.2006.00795.x

Steinman, A., Isoherranen, N., Ashoach, O., & Soback, S. (2002). Pharmacokinetics of gentamicin C1, C1a and C2 in horses after single intravenous dose. *Equine Veterinary Journal*, 34(6), 615-618.

Stockwell, V. O., & Duffy, B. (2012). Use of antibiotics in plant agriculture. *Revue Scientifique Et Technique (International Office of Epizootics)*, 31(1), 199-210. https://doi.org/10.20506/rst.31.1.2104

Stowe, C. M. (1965). The Sulfonamides. In L. Meyer Jones (Ed.), *Veterinary pharmacology and therapeutics* (3rd ed., pp. 458-502). Ames, IA: Iowa State University Press.

Stowe, C. M. (1976). History of veterinary pharmacotherapeutics in the United States. *Journal of the American Veterinary Medical Association*, 169(1), 83-89.

Subbiah, M., Shah, D. H., Besser, T. E., Ullman, J. L., & Call, D. R. (2012). Urine from treated cattle drives selection for cephalosporin resistant *Escherichia coli* in soil. *PLoS One*, 7(11), e48919. https://doi.org/10.1371/journal.pone.0048919

Sun, Y., Scruggs, D. W., Peng, Y., Johnson, J. R., & Shukla, A. J. (2004). Issues and challenges in developing long-acting veterinary antibiotic formulations. *Advanced Drug Delivery Reviews*, 56(10), 1481-1496. https://doi.org/10.1016/j addressed.2004.02.009

Sundlof, S. F., Craigmill, A. C., & Riviere, J. E. (1986). Food Animal Residue Avoidance Databank (FARAD): A pharmacokinetic-based information resource. *Journal of Veterinary Pharmacology and Therapeutics*, 9(3), 237-245.

Syriopoulou, V. P., Harding, A. L., Goldmann, D. A., & Smith, A. L. (1981). In vitro antibacterial activity of fluorinated analogs of chloramphenicol and thiamphenicol. *Antimicrobial Agents and Chemotherapy*, 19(2), 294-297. https://doi.org/10.1128/aac.19.2.294

Tang, K. L., Caffrey, N. P., Nóbrega, D. B., Cork, S. C., Ronksley, P. E., Barkema, H. W., ... Ghali, W. A. (2017). Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: A systematic review and meta-analysis. *The Lancet. Planetary Health*, 1(8), e316-e327. https://doi.org/10.1016/S2542-5196(17)30141-9

Tello, A., Austin, B., & Telfer, T. C. (2012). Selective pressure of antibiotic pollution on bacteria of importance to public health. *Environmental Health Perspectives*, 120(8), 1100-1106. https://doi.org/10.1289/ehp.1104650
Teske, R. H. (1993). Microbiological significance of drug residues in food: Welcome and introduction. *Veterinary and Human Toxicology*, 35(Suppl 1), 1-2.

Thacker, P. A. (2013). Alternatives to antibiotics as growth promoters for use in swine production: A review. *Journal of Animal Science and Biotechnology*, 4(1), 35. https://doi.org/10.1186/2049-1891-4-35

Thiele-Bruhn, S. (2003). Pharmaceutical antibiotic compounds in soils - A review. *Journal of Plant Nutrition and Soil Science*, **166**(2), 145-167. https://doi.org/10.1002/jpln.200390023

Thomas, N., & Lo, C. Y. (2020). The macrosecuritization of antimicrobial resistance in China. *Journal of Global Security Studies*, 5(2), 361-378. https://doi.org/10.1093/jogss/ogz038

Toutain, P.-L., & Bousquet-Melou, A. (2013). The consequences of generic marketing on antibiotic consumption and the spread of microbial resistance: The need for new antibiotics. *Journal of Veterinary Pharmacology and Therapeutics*, **36**(5), 420-424. https://doi.org/10.1111/jvp.12061

Toutain, P. L., & Bousquet-Melou, A. (2014). Rebuttal to the reaction of the EGGVP to the review article "the consequences of generic marketing on antibiotic consumption and the spread of microbial resistance: The need for new antibiotics". *Journal of Veterinary Pharmacology and Therapeutics*, **37**(6), 618-623. https://doi.org/10.1111/jvp.12166

Toutain, P.-L., Bousquet-Mélou, A., Damborg, P., Ferran, A. A., Mevius, D., Pelligand, L., ... Lees, P. (2017). En route towards European clinical breakpoints for veterinary antimicrobial susceptibility testing: A position paper explaining the VetCAST approach. *Frontiers in Microbiology*, 8, 2344. https://doi.org/10.3389/fmicb.2017.02344

Toutain, P.-L., del Castillo, J. R. E., & Bousquet-Mélou, A. (2002). The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics. *Research in Veterinary Science*, **73**(2), 105-114. https://doi.org/10.1016/S0034-5288(02)00039-5

Toutain, P.-L., Ferran, A. A., Bousquet-Melou, A., Pelligand, L., & Lees, P. (2016). Veterinary medicine needs new green antimicrobial drugs. *Frontiers in Microbiology*, 7, 1196. https://doi.org/10.3389/fmicb.2016.01196

Toutain, P.-L., Potter, T., Pelligand, L., Lacroix, M., Illambas, J., & Lees, P. (2017). Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: The case of tulathromycin in the calf. *Journal of Veterinary Pharmacology and Therapeutics*, **40**(1), 16-27. https://doi.org/10.1111/jvp.12333

Toutain, P.-L., Sidhu, P. K., Lees, P., Rassouli, A., & Pelligand, L. (2019). VetCAST method for determination of the pharmacokinetic-pharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol antimicrobial susceptibility testing in cattle. *Frontiers in Microbiology*, 10, 1310. https://doi.org/10.3389/fmicb.2019.01310

Tschape, H. (1994). The spread of plasmids as a function of bacterial adaptability. *FEMS Microbiology Ecology*, **15**(1-2), 23-31. https://doi.org/10.1111/j.1574-6941.1994.tb00226.x

van Belkum, A. (2008). Methicillin-resistant and -susceptible *Staphylococcus aureus* sequence type 398 in pigs and humans. *Emerging Infectious Diseases*, **14**(3), 479-483. https://doi.org/10.3201/eid1403.0760

van Belkum, A., Burnham, C.-A.-D., Rossen, J. W. A., Mallard, F., Rochas, O., & Dunne, W. M. (2020). Innovative and rapid antimicrobial susceptibility testing systems. *Nature Reviews Microbiology*, **18**, 299-311. https://doi.org/10.1038/s41579-020-0327-x

Van Boeckel, T. P., Brower, C., Gilbert, M., Grenfell, B. T., Levin, S. A., Robinson, T. P., ... Laxminarayan, R. (2015). Global trends in antimicrobial use in food animals. *Proceedings of the National Academy of Sciences*, **112**(18), 5649-5654. https://doi.org/10.1073/pnas.1503141112

Van Boeckel, T. P., Glennon, E. E., Chen, D., Gilbert, M., Robinson, T. P., Grenfell, B. T., ... Laxminarayan, R. (2017). Reducing antimicrobial

use in food animals. *Science*, **357**(6358), 1350-1352. https://doi.org/10.1126/science.aao1495

van Boven, M., Veldman, K. T., de Jong, M. C. M., & Mevius, D. J. (2003). Rapid selection of quinolone resistance in *Campylobacter jejuni* but not in *Escherichia coli* in individually housed broilers. *The Journal of Antimicrobial Chemotherapy*, **52**(4), 719-723. https://doi.org/10.1093/jac/dkg402

van den Bogaard, A. E., Jensen, L. B., & Stobberingh, E. E. (1997). Vancomycin-resistant Enterococci in Turkeys and farmers. *New England Journal of Medicine*, **337**(21), 1558-1559. https://doi.org/10.1056/NEJM199711203372117

van den Bogaard, A., & Stobberingh, E. (1996). Time to ban all antibiotics as animal growth-promoting agents? *The Lancet*, **348**(9027), 619. https://doi.org/10.1016/S0140-6736(05)64838-6

van den Bogaard, A. E., & Stobberingh, E. E. (1999). Antibiotic usage in animals: Impact on Bacterial resistance and public health. *Drugs*, **58**(4), 589-607. https://doi.org/10.2165/00003495-199958040-00002

van Duijkeren, E., Greko, C., Pringle, M., Baptiste, K. E., Catry, B., Jukes, H., ... Torneke, K. (2014). Pleuromutilins: Use in food-producing animals in the European Union, development of resistance and impact on human and animal health. *Journal of Antimicrobial Chemotherapy*, **69**(8), 2022-2031. https://doi.org/10.1093/jac/dku123

van Gogh, H., van Deurzen, E. J., van Duin, C. T., & van Miert, A. S. (1984). Effect of staphylococcal enterotoxin B-induced diarrhoea on the pharmacokinetics of sulphadimidine in the goat. *Journal of Veterinary Pharmacology and Therapeutics*, **7**(4), 303-305.

Van Gogh, H., & Van Miert, A. S. (1977). The absorption of sulfonamides from the gastrointestinal tract during pyrogen-induced fever in kids and goats. *Zentralblatt Fur Veterinarmedizin. Reihe A*, **24**(6), 503-510.

van Hoek, A. H. A. M., Mevius, D., Guerra, B., Mullany, P., Roberts, A. P., & Aarts, H. J. M. (2011). Acquired antibiotic resistance genes: An overview. *Frontiers in Microbiology*, 2, 1-27. https://doi.org/10.3389/fmicb.2011.00203

van Miert, A. (1990). Influence of febrile disease on the pharmacokinetics of veterinary drugs. *Annales De Recherches Veterinaires. Annals of Veterinary Research*, **21**(Suppl 1), 11S-28S.

van Miert, A. S. (1994). The sulfonamide-diaminopyrimidine story. *Journal of Veterinary Pharmacology and Therapeutics*, **17**(4), 309-316.

Van Miert, A. S., & Atmakusuma, A. (1970). Comparative observations on the production of fever by bacterial pygens and leucocytic pygen in goats and rabbits. *Zentralblatt Fur Veterinarmedizin. Reihe A*, **17**(2), 174-184.

van Miert, A. S., & Frens, J. (1968). The reaction of different animal species to bacterial pygens. *Zentralblatt Fur Veterinarmedizin. Reihe A*, **15**(6), 532-543.

Van Schyndel, S. J., Carrier, J., Bogado Pascottini, O., & LeBlanc, S. J. (2018). The effect of pegbovirgrastim on circulating neutrophil count in dairy cattle: A randomized controlled trial. *PLoS One*, **13**(6), e0198701. https://doi.org/10.1371/journal.pone.0198701

Vandenberg, O., Durand, G., Hallin, M., Diefenbach, A., Gant, V., Murray, P., ... van Belkum, A. (2020). Consolidation of clinical microbiology laboratories and introduction of transformative technologies. *Clinical Microbiology Reviews*, **33**(2), 1-19. https://doi.org/10.1128/CMR.00057-19

Varma, K. J., Adams, P. E., Powers, T. E., Powers, J. D., & Lamendola, J. F. (1986). Pharmacokinetics of florfenicol in veal calves. *Journal of Veterinary Pharmacology and Therapeutics*, **9**(4), 412-425. https://doi.org/10.1111/j.1365-2885.1986.tb00062.x

Vasseur, M. V., Lacroix, M. Z., Toutain, P.-L., Bousquet-Melou, A., & Ferran, A. A. (2017). Infection-stage adjusted dose of beta-lactams for parsimonious and efficient antibiotic treatments: A Pasteurella multocida experimental pneumonia in mice. *PLoS One*, **12**(8), e0182863. https://doi.org/10.1371/journal.pone.0182863

Vasseur, M. V., Laurentie, M., Rolland, J.-G., Perrin-Guyomard, A., Henri, J., Ferran, A. A., ... Bousquet-Mélou, A. (2014). Low or high doses
of cefquinome targeting low or high bacterial inocula cure *Klebsiella pneumoniae* lung infections but differentially impact the levels of anti-biotic resistance in fecal flora. *Antimicrobial Agents and Chemotherapy*, 58(3), 1744-1748. https://doi.org/10.1128/AAC.02135-13

Vecino, E. (2014). Reaction to the review article "the consequences of generic marketing on antibiotic consumption and the spread of microbial resistance: The need for new antibiotics". *Journal of Veterinary Pharmacology and Therapeutics*, 37(6), 615-617. https://doi.org/10.1111/jvp.12167

Verdon, E., Couedor, P., Roudaut, B., & Sandérs, P. (2005). Multiresidue method for simultaneous determination of ten quinolone antibacterial residues in multimatrix/multispecies animal tissues by liquid chromatography with fluorescence detection: Single laboratory validation study. *Journal of AOAC International*, 88(4), 1179-1192.

Vermeulen, B. (2002). Drug administration to poultry. *Advanced Drug Delivery Reviews*, 54(6), 795-803. https://doi.org/10.1016/S0169-409X(02)00069-8

Villarino, N., Brown, S. A., & Martín-Jiménez, T. (2013). The role of the macrolide tulathromycin in veterinary medicine. *Veterinary Journal (London, England): 1997*, 198(2), 352-357. https://doi.org/10.1016/j.tvjl.2013.07.032

Wagenaar, J. A., Bergen, M. A. P. V., Mueller, M. A., Wassenaar, T. M., & Carlton, R. M. (2005). Phage therapy reduces Campylobacter jejuni colonization in broilers. *Veterinary Microbiology*, 109(3-4), 275-283. https://doi.org/10.1016/j.vetmic.2005.06.002

Walker, R. (2000). Current topics in veterinary drug therapy: The use of fluoroquinolones for companion animal antimicrobial therapy. *Australian Veterinary Journal*, 78(2), 84-90. https://doi.org/10.1111/j.1751-0813.2000.tb10528.x

Wallerstein, R. O., Condit, P. K., Kasper, C. K., Brown, J. W., & Morrison, F. R. (1969). Statewide study of chloramphenicol therapy and fatal aplastic anemia. *JAMA*, 208(11), 2045-2050.

Wallinga, D., & Burch, D. G. S. (2013). Does adding routine antibiotics to animal feed pose a serious risk to human health? *BMJ (Clinical Research Ed.)*, 347, f4214. https://doi.org/10.1136/bmj.f4214

Wang, J., MacNeil, J. D., & Kay, J. F. (2012). *Chemical analysis of antibiotic residues in food*. Hoboken, NJ: Wiley & Sons.

Watanabe, T., & Fukasawa, T. (1961). Episome-mediated transfer of drug resistance in Enterobacteriaceae. III. Transduction of resistance factors. *Journal of Bacteriology*, 82, 202-209.

Watson, A. D. J. (1972). Chloramphenicol plasma levels in the dog: A comparison of oral, subcutaneous and intramuscular administration. *Journal of Small Animal Practice*, 13(3), 147-152. https://doi.org/10.1111/j.1748-5827.1972.tb06323.x

Watson, A. (1991). Chloramphenicol 2. Clinical pharmacology in dogs and cats. *Australian Veterinary Journal*, 68(1), 2-5. https://doi.org/10.1111/j.1751-0813.1991.tb09827.x

Weese, J. S., Blondeau, J. M., Boothe, D., Breitschwerdt, E. B., Guardabassi, L., Hillier, A., ... Sykes, J. E. (2011). Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: Antimicrobial guidelines working group of the International Society for Companion Animal Infectious Diseases. *Veterinary Medicine International*, 2011, 1-9. https://doi.org/10.4061/2011/263768

Weese, J. S., Blondeau, J., Boothe, D., Guardabassi, L. G., Gumley, N., Papich, M., ... Sykes, J. (2019). International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. *The Veterinary Journal*, 247, 8-25. https://doi.org/10.1016/j.tvjl.2019.02.008

Weese, J. S., Giguère, S., Guardabassi, L., Morley, P. S., Papich, M., Ricciuto, D. R., & Sykes, J. E. (2015). ACVIM consensus statement on therapeutic antimicrobial use in animals and antimicrobial resistance. *Journal of Veterinary Internal Medicine*, 29(2), 487-498. https://doi.org/10.1111/jvim.12562

Weese, J. S., & van Duijkeren, E. (2010). Methicillin-resistant *Staphylococcus aureus* and *Staphylococcus pseudintermedius* in veterinary medicine. *Veterinary Microbiology*, 140(3-4), 418-429. https://doi.org/10.1016/j.vetmic.2009.01.039

Wegener, H. C. (1998). Historical yearly usage of glycopeptides for animals and humans: The American-European Paradox Revisited. *Antimicrobial Agents and Chemotherapy*, 42(11), 3049. https://doi.org/10.1128/AAC.42.11.3049

Wegener, H. C., Aarestrup, F. M., Jensen, L. B., Hammerum, A. M., & Bager, F. (1999). Use of antimicrobial growth promoters in food animals and *Enterococcus faecium* resistance to therapeutic antimicrobial drugs in Europe. *Emerging Infectious Diseases*, 5(3), 329-335. https://doi.org/10.3201/eid0503.990303

Welch, H. (1957). Problems of antibiotics in food as the food and drug administration sees them. *American Journal of Public Health and the Nations Health*, 47(6), 701-705. https://doi.org/10.2105/AJPH.47.6.701

Whitehead, M. L., Chambers, D., Lees, P., & Toutain, P. L. (2019). The UK veterinary profession's response to antimicrobial resistance. *Regulatory Rapporteur*, 16(3), 10-12.

WHO Advisory Group on Integrated Surveillance of Antimicrobial Resistance, & World Health Organization (2017). *Critically important antimicrobials for human medicine: Ranking of antimicrobial agents for risk management of antimicrobial resistance due to non-human use*. Retrieved from http://apps.who.int/iris/bitstream/10665/255027/1/9789241512220-eng.pdf

Williamson, J., & Cravens, W. (1972). Feed industry reaction and implications. *Journal of Animal Science*, 35(6), 1338-1339.

Witkamp, R. F., Nijmeijer, S. M., Monshouwer, M., & Van Miert, A. S. (1995). The antibiotic tiamulin is a potent inducer and inhibitor of cytochrome P4503A via the formation of a stable metabolic intermediate complex. Studies in primary hepatocyte cultures and liver microsomes of the pig. *Drug Metabolism and Disposition: the Biological Fate of Chemicals*, 23(5), 542-547.

Witkamp, R. F., Nijmeijer, S. M., Yun, H., Noordhoek, J., & van Miert, A. S. (1993). Sulfamethazine as a model compound to assess sex hormone-dependent cytochrome P-450 activity in rats. *Drug Metabolism and Disposition: the Biological Fate of Chemicals*, 21(3), 441-446.

Witkamp, R. F., Yun, H. I., van't Klooster, G. A., van Mosel, J. F., van Mosel, M., Ensink, J. M., ... van Miert, A. S. (1992). Comparative aspects and sex differentiation of plasma sulfamethazine elimination and metabolite formation in rats, rabbits, dwarf goats, and cattle. *American Journal of Veterinary Research*, 53(10), 1830-1835.

Woodward, K. N. (1998). The use of microbiological end-points in the safety evaluation and elaboration of maximum residue limits for veterinary drugs intended for use in food producing animals. *Journal of Veterinary Pharmacology and Therapeutics*, 21(1), 47-53.

Wu, G., Day, M. J., Mafura, M. T., Nunez-Garcia, J., Fenner, J. J., Sharma, M., ... Mevius, D. (2013). Comparative analysis of ESBL-positive *Escherichia coli* isolates from animals and humans from the UK, The Netherlands and Germany. *PLoS One*, 8(9), e75392. https://doi.org/10.1371/journal.pone.0075392

Yang, Y., Feye, K. M., Shi, Z., Pavlidis, H. O., Kogut, M., Ashworth, A. J., & Ricke, S. C. (2019). A historical review on antibiotic resistance of foodborne Campylobacter. *Frontiers in Microbiology*, 10, 1509. https://doi.org/10.3389/fmicb.2019.01509

Yazdankhah, S., Rudi, K., & Bernhoft, A. (2014). Zinc and copper in animal feed - Development of resistance and co-resistance to antimicrobial agents in bacteria of animal origin. *Microbial Ecology in Health & Disease*, 25, 1-7. https://doi.org/10.3402/mehd.v25.25862

Zhu, Y.-G., Gillings, M., Simonet, P., Stekel, D., Banwart, S., & Penuelas, J. (2017). Microbial mass movements. *Science*, 357(6356), 1099-1100. https://doi.org/10.1126/science.aao3007
Zhu, Y.-G., Johnson, T. A., Su, J.-Q., Qiao, M., Guo, G.-X., Stedtfeld, R. D., ... Tiedje, J. M. (2013). Diverse and abundant antibiotic resistance genes in Chinese swine farms. *Proceedings of the National Academy of Sciences*, 110(9), 3435-3440. https://doi.org/10.1073/pnas.1222743110

Ziv, G. (1980a). Practical pharmacokinetic aspects of mastitis therapy-1: Parenteral treatment. *Veterinary Medicine, Small Animal Clinician*: VM, SAC, 75(2), 277-290.

Ziv, G. (1980b). Practical pharmacokinetic aspects of mastitis therapy-2: Practical & therapeutic applications. *Veterinary Medicine, Small Animal Clinician*: VM, SAC, 75(3), 469-474.

Ziv, G. (1980c). Practical pharmacokinetic aspects of mastitis therapy-3: Intramammary treatment. *Veterinary Medicine, Small Animal Clinician*: VM, SAC, 75(4), 657-670.

SUPPORTING INFORMATION

Additional supporting information may be found online in the
Supporting Information section.

How to cite this article: Lees P, Pelligand L, Giraud E, Toutain P-L. A history of antimicrobial drugs in animals: Evolution and revolution. *J vet Pharmacol Therap*. 2021;44:137-171. https://doi.org/10.1111/jvp.12895