# Publisher Correction: LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition

Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, et al.

► To cite this version:

Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, et al. Publisher Correction: LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition. EMBO Molecular Medicine, 2024, 16 (9), pp.2262-2267. 10.1038/s44321-024-00114-1. hal-05401289

HAL Id: hal-05401289

https://hal.science/hal-05401289v1

Submitted on 5 Dec 2025

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<figure><img src="image_1.png" /></figure>
Publisher Correction: LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition

Sarah Proteau ID, Imène Krossa, Chrystel Husser ID, Maxime Guéguinou ID, Federica Sella ID, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet ID, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon-Estève ID, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest ID, Nathalie M Mazure ID, Frédéric Bost, Stéphanie Baillif, Solange Landreville ID, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan-Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto & Thomas Strub ID

Correction to: EMBO Mol Med (2023) 15:e17719. https://doi.org/10.15252/emmm.202317719 | Published online 20 August 2024

During the publication proofing process, the author identified
several formatting errors. These errors were not corrected by the
publisher prior to the release of the publication. These errors are
now corrected.
Figure 7D is corrected.

A

<figure><img src="image_2.png" /></figure>

B

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C

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D

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<table><caption>Figure 7. Original.</caption><thead><tr><td></td><td>GEP</td><td>LKB1 loss sign</td></tr></thead><tbody><tr><td>AUC</td><td>0.88</td><td>0.89</td></tr><tr><td>p-value</td><td>2.32x10<sup>-11</sup></td><td>1.24x10<sup>-11</sup></td></tr></tbody></table>
A

<figure><img src="image_6.png" /></figure>

B

<figure><img src="image_7.png" /></figure>

C

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D

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<table><caption>Figure 7. Corrected.</caption><thead><tr><th></th><th>GEP</th><th>LKB1 loss sign</th></tr></thead><tbody><tr><th>AUC</th><td>0.88</td><td>0.89</td></tr><tr><th>p-value</th><td>2.32x10<sup>-11</sup></td><td>1.24x10<sup>-11</sup></td></tr></tbody></table>
Figure EV5 is corrected.

A

<figure><img src="image_10.png" /></figure>

B

<figure><img src="image_11.png" /></figure>

C

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D

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<table><thead><tr><td></td><td>GEP</td><td>LKB1 loss sign</td></tr></thead><tbody><tr><td>AUC</td><td>0.75</td><td>0.78</td></tr><tr><td>p-value</td><td>4.2x10<sup>-5</sup></td><td>6.8x10<sup>-6</sup></td></tr></tbody></table>

Figure EV5. Original.
A

<figure><img src="image_14.png" /></figure>

B

<figure><img src="image_15.png" /></figure>

C

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D

<figure><img src="image_17.png" /></figure>

<table><caption>Figure EV5. Corrected.</caption><thead><tr><th></th><th>GEP</th><th>LKB1 loss sign</th></tr></thead><tbody><tr><th>AUC</th><td>0.75</td><td>0.78</td></tr><tr><th>p-value</th><td>4.2x10<sup>-5</sup></td><td>6.8x10<sup>-6</sup></td></tr></tbody></table>

The Acknowledgments section is corrected.

The Acknowledgments section is corrected from:

The wild-type and mutant SIK2 expression vectors were kindly provided by Dr. Dong-Yan Jin (The University of Hong Kong, Hong Kong). This work was supported by the French government, INSERM, La Ligue Nationale contre le cancer, INCA PLBio to C. B. (INCA-16070), Labex Signalife and La Ville de Nice. SP is fellowship from La Ligue Nationale contre le cancer. SL is a Junior 2 Research Scholar of the Fonds de recherche du Québec-Santé

(FRQS). ST was supported by the FRQS Young Clinician Scientist Seed Grant, the FRQS Clinician Scientist Junior 1&2 Salary Award, the Institut du Cancer de Montréal Establishment Award, and the Université de Montréal Roger Des Groseillers Research Chair in Hepatopancreatobiliary Surgical Oncology. The procurement of human UM tissues was possible thanks to the Quebec Uveal Melanoma Biobank (funded by the Vision Health Research Network, a thematic network supported by the FRQS), and the Centre hospitalier de l'Université de Montréal hepatopancreatobiliary cancer biobank and prospective registry. The authors thank the following persons for patient recruitment, biospecimen
acquisition and handling, and prospective maintenance of clin-
icopathological data: Dr. C. Bellerive and S. Marcoux (Clinique des
tumeurs oculaires du CHU de Québec-Université Laval), as well as
L. Rousseau, S. Langevin and J. Bilodeau (CHUM hepatopancrea-
tobiliary cancer and prospective registry). I.K is a former fellowship
from Région Provence-Alpes-Côte d'Azur "Emplois jeunes doc-
torants". T.S acknowledges the financial support provided by La
Fondation pour la Recherche Médicale (FRM ARF201809006989)
and the Fondation de France (00120250/WB-2021-33281). The
authors thank the C3M imaging facility (INSERM U1065)
supported by IBiSA, the C3M genomic facility (GenoC3M), le
conseil Régional and la cancéropole PACA. The authors thank
Nicolas Nottet for analyses of sequencing data using the MAGeCK
method. The authors thank Celine Keim (IGBMC, Strasbourg) for
analyses of sequencing data.

To: (changes in bold)

The wild-type and mutant SIK2 expression vectors were kindly
provided by Dr. Dong-Yan Jin (The University of Hong Kong,
Hong Kong). This work was supported by the French government,
INSERM, La Ligue Nationale contre le cancer, INCA PLBio to C.B.
(INCA-16070), Labex Signalife and La Ville de Nice. S.P. is
fellowship from La Ligue Nationale contre le cancer. S.L. is a Junior
2 Research Scholar of the Fonds de recherche du Québec-Santé
(FRQS). ST was supported by the FRQS Young Clinician Scientist
Seed Grant, the FRQS Clinician Scientist Junior 1&2 Salary Award,
the Institut du Cancer de Montréal Establishment Award, and the
Université de Montréal Roger Des Groseillers Research Chair in
Hepatopancreatobiliary Surgical Oncology. The procurement of

human UM tissues was possible thanks to the Quebec Uveal
Melanoma Biobank (funded by the Vision Health Research
Network, a thematic network supported by the FRQS), and the
Centre hospitalier de l'Université de Montréal hepatopancreato-
biliary cancer biobank and prospective registry. The authors thank
the following persons for patient recruitment, biospecimen
acquisition and handling, and prospective maintenance of clin-
icopathological data: Dr. C. Bellerive and S. Marcoux (Clinique des
tumeurs oculaires du CHU de Québec-Université Laval), as well as
L. Rousseau, S. Langevin and J. Bilodeau (CHUM hepatopancrea-
tobiliary cancer and prospective registry). I.K. is a former fellow-
ship from Région Provence-Alpes-Côte d'Azur "Emplois jeunes
doctorants". T.S. acknowledges the financial support provided by
La Fondation pour la Recherche Médicale (FRM
ARF201809006989) and the Fondation de France (00120250/WB-
2021-33281). The authors thank the C3M imaging facility
(INSERM U1065) supported by IBiSA, the C3M genomic facility
(GenoC3M), le conseil Régional and la cancéropole PACA. The
authors thank Nicolas Nottet for analyses of sequencing data using
the MAGeCK method. The authors thank Celine Keim (IGBMC,
Strasbourg) for analyses of sequencing data. **C.B. and S.L. thank
The France Canada Research Fund.**

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© The Author(s) 2024