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Glossary

<table><tr><td>Aβ</td><td>Amyloid beta</td></tr><tr><td>Ac-Tau</td><td>Acetylation tau</td></tr><tr><td>AD</td><td>Alzheimer's disease</td></tr><tr><td>ADAM</td><td>A disintegrin and metalloproteinase</td></tr><tr><td>AGO2</td><td>Argonaute RISC Catalytic Component 2</td></tr><tr><td>AKT</td><td>Protein kinase B ("AK" AKR mouse strains; T thymoma)</td></tr><tr><td>ALS</td><td>Amyotrophic lateral sclerosis</td></tr><tr><td>APP</td><td>Amyloid beta precursor protein</td></tr><tr><td>BACE1</td><td>β-site amyloid precursor protein-cleaving enzyme 1</td></tr><tr><td>BDNF</td><td>Brain-derived neurotrophic factor</td></tr><tr><td>CNS</td><td>Central nervous system</td></tr><tr><td>CSF</td><td>Cerebrospinal fluid</td></tr><tr><td>CX3CL1</td><td>C-X3-C motif chemokine ligand 1</td></tr><tr><td>DGCR8</td><td>DiGeorge critical region 8</td></tr><tr><td>FTD</td><td>Frontotemporal dementia</td></tr><tr><td>GABA</td><td>Gemma (γ)-aminobutyric acid</td></tr><tr><td>GSK3</td><td>Glycogen synthase kinase 3β</td></tr><tr><td>HD</td><td>Huntington's disease</td></tr><tr><td>Htt</td><td>Huntingtin</td></tr><tr><td>IGF-1</td><td>Insulin-like growth factor</td></tr><tr><td>MeCP2</td><td>Methyl-CpG binding protein 2</td></tr><tr><td>mHTT</td><td>Mutant huntingtin protein</td></tr><tr><td>mRNA</td><td>Messenger RNA</td></tr><tr><td>miRNA</td><td>Micro RNA</td></tr><tr><td>miRNPs</td><td>Micro-ribonucleoprotein</td></tr><tr><td>miRNPs</td><td>Micro-ribonucleoprotein</td></tr><tr><td>MMP-9</td><td>Matrix metallopeptidase-9</td></tr><tr><td>MRI</td><td>Magnetic resonance imaging</td></tr><tr><td>MS</td><td>Multiple sclerosis</td></tr><tr><td>NAWM</td><td>Normal-appearing white matter</td></tr><tr><td>ND</td><td>Neurodegenerative disease</td></tr><tr><td>NfL</td><td>Neurofilament light chain</td></tr><tr><td>NFT</td><td>Neurofibrillary tangles</td></tr><tr><td>NF-κB</td><td>Nuclear factor kappa-light-chain-enhancer' of activated B-cells</td></tr><tr><td>NGS</td><td>Next generation sequencing</td></tr><tr><td>NMRS</td><td>Nuclear magnetic resonance spectroscopy</td></tr><tr><td>Nrf2</td><td>Nuclear factor erythroid 2-related factor 2</td></tr><tr><td>PD</td><td>Parkinson's disease</td></tr><tr><td>PET</td><td>Positron emission tomography scan</td></tr><tr><td>PGC-1α</td><td>Proliferator-activated receptor γ coactivator 1 α</td></tr><tr><td>PI3K</td><td>Phosphoinositide 3-kinases</td></tr><tr><td>pre-miRNA</td><td>Precursor microRNA</td></tr><tr><td>PTEN</td><td>Phosphatase and tensin homolog</td></tr><tr><td>PTM</td><td>Post-translational modification</td></tr><tr><td>RT-qPCR</td><td>Quantitative reverse transcription polymerase chain reaction</td></tr><tr><td>RBP</td><td>RNA binding proteins</td></tr><tr><td>RISC</td><td>RNA-induced silencing complex</td></tr><tr><td>siRNAs</td><td>Small interfering RNAs</td></tr><tr><td>SIRT1</td><td>Sirtuin-1</td></tr><tr><td>SOD1</td><td>Superoxide dismutase</td></tr><tr><td>UMN</td><td>Upper motor neuron</td></tr><tr><td>UVR</td><td>Ultraviolet radiation</td></tr></table>