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											BIO Web Conf.
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<div><strong>Volume </strong>194, 2025				</div>
				
					                International Scientific Conference on Biotechnology and Food Technology (BFT-2025)
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					Article Number
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<td>01028</td>
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					Number of page(s)
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<td>8</td>
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<th>DOI</th>
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<a href="https://doi.org/10.1051/bioconf/202519401028">
					https://doi.org/10.1051/bioconf/202519401028
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<th>Published online</th>
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				14 November 2025
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## Synthesis and study of substituted 1-((1,3-dioxolan-4-yl)methyl)-1H-1,2,4-triazoles as plant growth regulators

Vladimir Talismanov11 and Sergei Popkov2

1 Moscow Institute of Physics and Technology, 141701, Dolgoprudny, Moscow Region, Russian Federation 2 Mendeleev University of Chemical Technology of Russia, 125047, Moscow, Russian Federation

1 Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

The search for new effective plant growth regulators characterized by low application rates, low toxicity, and rapid biodegradability in plant-based products, soil, and the environment has become increasingly important in light of the growing regulatory requirements for pesticides. The search for new plant growth stimulants among the well-studied 1,2,4-triazole and 1,3-dioxolane derivatives allows for the combination of the growth-regulating properties of both 1,2,4- triazole and 1,3-dioxolane in a single molecule. An effective two-step method for the synthesis of substituted 1-((1,3-dioxolan-4-yl)methyl)-1H- 1,2,4-triazoles has been developed for the purpose of testing their growth- regulating activity. Using azeotropic removal of water, this reaction produced intermediate 4-chloromethyl-1,3-dioxolanes in high yields and with a high level of purity. In the second stage, the resulting 4-chloromethyl- 1,3-dioxolanes were alkylated with the sodium salt of 1,2,4-triazole by refluxing in dimethylformamide. The compounds were obtained in moderate yields and required purification by column chromatography and conversion to stable and easy-to-handle oxalate salts. The compounds were identified using NMR and IR spectroscopy. The synthesized compounds were tested for growth-regulating activity in vivo using agar medium on cucumber seedlings at concentrations ranging from 0.001 to 10 mg/L. Water was used as a reference standard. Tests were conducted over an 8-day period. The test results demonstrated significant retardant properties of the studied compounds when applied to the above-ground parts of plants, with the compounds stimulating the accumulation of both wet and dry biomass at a range of concentrations. The conducted studies demonstrated the potential of searching for new retardants in the 1-((1,3-dioxolan-4-yl)methyl)-1H- 1,2,4-triazole series.

© The Authors, published by EDP Sciences, 2025

This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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