# Regulatory evolution tuning pigmentation intensity quantitatively in Drosophila

Benjamin Prud'homme

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## To cite this version:

Benjamin Prud'homme. Regulatory evolution tuning pigmentation intensity quantitatively in Drosophila. Science Advances, 2024, 10.1126/sciadv.adl2616. hal-04788428

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Submitted on 18 Nov 2024

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Regulatory evolution tuning pigmentation intensity quantitatively in *Drosophila*

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Katharina Bachem¹†, Xinyi Li¹†, Stefano Ceolin¹, Bettina Mühling¹, David Hörl², Hartmann

Harz², Heinrich Leonhardt², Laurent Arnoult³, Sabrina Weber¹, Blair Matarlo¹, Benjamin

Prud'homme³, Nicolas Gompel¹,⁴*

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¹ Department of Evolutionary Ecology, Ludwig-Maximilians Universität München; München, 82152, Germany.

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² Human Biology and Bioimaging, Ludwig-Maximilians Universität München; München, 82152, Germany.

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³ Institut de Biologie du Développement de Marseille, Aix-Marseille Université; Marseille, 13288, France.

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⁴ Bonn Institute for Organismic Biology, University of Bonn; Bonn, 53115, Germany.

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† These authors contributed equally to this work

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* Corresponding author. Email: ngompel@uni-bonn.de.

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**Abstract:** Quantitative variation in attributes such as color, texture or stiffness dominates morphological diversification. It results from combinations of alleles at many Mendelian loci. Here, we identify an additional source of quantitative variation among species, continuous evolution in a gene regulatory region. Specifically, we examined the modulation of wing pigmentation in a group of fly species, and showed that inter-species variation correlated with the quantitative expression of the pigmentation gene *yellow*. This variation results from an enhancer of *yellow* determining darkness through species-specific activity. We mapped the divergent activities between two sister species and found the changes to be broadly distributed along the enhancer. Our results demonstrate that enhancers can act as dials fueling quantitative morphological diversification by modulating trait properties.

**Teaser:** Continuous evolutionary changes in a gene regulatory region result in quantitative morphological variation among species.
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### Introduction

Efforts to unravel the genetic underpinnings of morphological diversity have developed in two directions (1). On one hand, statistical methods, including quantitative trait locus mapping and genome-wide association studies have established that large numbers of loci typically account for continuous variation in traits such as Human height. On the other hand, evolutionary developmental biologists have strongly focused on discrete, qualitative changes in the spatial distribution of pattern elements, leading to trait gains and losses, and single genes determining those changes. These include pigmentation patterns on insect wings (2-4), sensory organ (5) as well as non-sensory hair (6-8) distribution in *Drosophila*, limb (9) or eye (10) loss in some vertebrate lineages, or leaf margin shape (11). These discrete traits, however, are defined by attributes that themselves vary in a quantitative way, fuelling diversification, as documented in countless faunas and floras. For instance, similar pattern elements on butterfly wings often differ by their hues (12); hairs across breeds of domesticated mammals vary dramatically from short and coarse to soft, long or curly (13, 14); skin stiffness among related reptile species changes with the mineralization of specific dermal structures (15). Yet, the molecular mechanisms generating quantitative variation of morphological attributes remain poorly studied or elusive, with some exceptions, such as the evolution of facial features in primates (16), trichome number (17) or bristle number (18) variation in flies. Is such quantitative variation in trait attributes a consequence of different allelic combinations in the gene regulatory network controlling trait formation? Or can it also be explained by variation at single loci, themselves producing quantitative variation?

Insects are notorious for the endless modulation of their colors (19). The shades of grey on the wings of different *Drosophila* species (20, 21) typically illustrate this quantitative variation (Fig. 1) and offer the possibility to track its genetic bases. Pigments embedded in the cuticle are produced by a metabolic network that converts DOPA and dopamine into colored deposits, including the black DOPA-melanin (22-24). Heritable quantitative variation in pigmentation intensity must therefore result from genetic variation in the gene regulatory network controlling this metabolic process. It remains, however, unclear how many genes of the regulatory network are involved in this variation, by which molecular mechanisms these genes change, and whether the same genes are recurrently modified during the evolutionary process. We therefore set to investigate by which mechanisms wing pigmentation intensity is modulated quantitatively among *Drosophila* species.

### Results

#### Wing pigmentation intensity illustrates continuous changes among *Drosophila* species

Focusing on a panel of eleven *Drosophila* species representing a broad range of wing pigmentation intensities in a phylogenetic clade that diverged less than 20 million years ago (25), we first examined quantitative variation in the amount of dark pigmentation (Fig. 1A). While inter-species variation in the lightly pigmented areas of the wing blade is moderate, the darker pattern elements form a continuum of variation among these eleven species and drive their diversification (Fig. 1B). To understand how pigmentation intensity is modulated continuously among species, we reasoned that the expression of the very genes that determine pigment deposit formation might have changed over evolutionary times. In principle, multiple nodes of the pigmentation metabolic network may have changed, accounting for quantitative differences observed among species. Several genes

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of the pigmentation network are identified and their function is, at least partly, characterized (23). Notably, the pathway leading to the production of black pigments requires the activity of the protein Yellow (26-28) and the spatial expression of this gene in the wing predicts the shape and location of dark pattern elements (2, 20, 29, 30). We therefore asked whether there is a quantitative relationship between the amount of Yellow protein and the levels of black pigmentation on adult wings (30).

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## *Drosophila* wing darkness varies with Yellow protein levels

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With a subset of seven selected species representing different intensity maxima (Fig. 1A), we used quantitative antibody staining to compare the relative accumulation of Yellow in their developing wings to the pigmentation levels of the corresponding adult wings. Specifically, we aligned antibody staining wing images of emerging pupae to the same reference used for mature adult pigmented wings (see methods), and compared the distribution of Yellow levels to that of dark pigments (Fig. 2). We found a monotonic relation between pigmentation and Yellow signal in all species. This relationship is non-linear and different for each species, indicating that there are additional parameters involved in the synthesis of black pigment. The pigmentation of paler species (*D. fuyamai*, *D. kurseongensis*, *D. prostipennis*; Fig. 2, E to G) seems to be more sensitive to Yellow levels as their higher slope values suggest (Fig. 2H). In these species, however, pigmentation is either saturating or limited by low Yellow expression levels. In darker species (*D. biarmipes*, *D. suzukii*, *D. prolongata*, *D. elegans*; Fig. 2, A to D), pigmentation intensity increases less rapidly as a function of Yellow concentration compared to paler species, but the much higher levels of Yellow expression explain the darker pigmentation (Fig. 2H). Beyond these differences, our results point to a quantitative relationship between the amount of Yellow and adult pigmentation intensity (Fig. 2H). Along with existing genetic data on the function of *yellow* (27, 28, 30), they support the notion that the expression of *yellow* tunes pigmentation to different shades of grey in the wings of *Drosophila*. Therefore, we next sought to understand by which molecular mechanisms Yellow levels have changed.

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## Changes in *yellow* regulatory regions drive quantitative gene expression changes

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Yellow expression in the wing is mainly regulated at the transcriptional level (2, 20, 25, 31) by an enhancer located upstream of the gene transcription start site (TSS), the *wing blade* enhancer (2, 32, 33). In spotted species, including those examined here (Fig. 1A), another element, the *spot* enhancer, entangled with the *wing blade* enhancer, contributes the additional pattern component at the anterior distal wing tip (2, 33). The spatial activity of the *spot* enhancer is directly governed by Distal-less and Engrailed, two transcription factors that otherwise pattern the developing wing (2, 20, 34). In principle, the quantitative modulation of *yellow* transcription could result from changes in the levels of its upstream regulators, or from local changes at the *yellow* locus, or both. If changes map to the *yellow* locus, they could range from mutations in the *cis*-regulatory region (*e. g.*, in transcription factor binding sites) to modification of RNA stability. Reasoning that changes in the levels of upstream regulators or in the stability of the gene product would have pleiotropic effects and are therefore less likely (35), we first examined the activity of *yellow* regulatory regions from different species. We used all eleven species from Fig. 1, which cover a range of pigmentation intensity maxima, and tested the regulatory activities of a region encompassing the *wing blade* and *spot* enhancers (*y5′*) of each species in transgenic reporter assays (Fig. 3A). To compare the regulatory activities of these relatively well conserved sequences (Fig. S1), we transformed the constructs in the same transregulatory
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environment, in *D. melanogaster*. We found that the regulatory regions of these species
drove striking quantitative differences in their levels of reporter expression (Fig. 3B),
notably in their domains of highest activity on the wing (Fig. 3B, histograms). In
particular, we observed that the maxima of reporter expression driven by *y5'* fragments in
*D. melanogaster* transgenics were correlated with the maxima of pigmentation intensity in
the corresponding species (Fig. 3C). This strongly suggests that the dramatic and
continuous variation in wing pigmentation intensity, caused by the variation in the distal
wing motifs, is explained, in part, by genetic changes in the *spot* regulatory element for
most species.

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Quantitative evolutionary changes are distributed across *yellow* regulatory region

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To track the regulatory origin of this evolutionary variation within y5', we focused on two
sister species with divergent wing pigmentation intensity, *D. biarmipes* and *D.
prostipennis* (Fig. 1A) with a high degree of sequence conservation (75% percent identity
along y5', Fig. 4A; divergence time 12 million years ago (25)). Sequence variation
underlying the difference of regulatory activity may range from changes in a single
transcription factor binding site driving most *cis*-regulatory activity, to multiple changes
distributed along the entire y5' region. We therefore set to map the evolutionary changes
with chimeric reporter constructs. The underlying assumption is that the regulatory
elements driving *yellow* expression have retained their relative positions. Yet, despite high
sequence conservation there is no evidence that enhancers have kept their location
between species. Hence, to make our mapping meaningful, we first analyzed the
distribution of regulatory information along *D. prostipennis* y5' (*y5 pros*) and compared it
to previous enhancer mapping along *D. biarmipes* y5' (*y5 bia*) (33) (Fig. S2). We designed
nested constructs for *y5 pros*, progressively removing sequence from the 5' end as we had
done for *y5 bia* (33) (Fig. S2D, *P* series) and quantified their activities in reporter assays.
We concluded from these experiments that the overall organization of regulatory
information was unchanged between these species, with in particular the *spot* enhancer,
responsible for the darker distal wing pigmentation (33), at comparable positions.
Interestingly, however, the core of the *spot* enhancer, which we previously defined in *D.
biarmipes* as a 196-bp sequence, *spot*<sup>196</sup> (Fig. 4A), that is necessary, but not sufficient for
the full *spot* enhancer activity (33), has undergone rearrangements between *D. biarmipes*
and *D. prostipennis* (Fig. 4A and Fig. S3). Indeed, in *D. prostipennis*, only the distal half
of the orthologous segment remained, and interestingly, it underwent a tandem
duplication, immediately followed by a ~700 bp indel (Fig. 4A and Fig. S3). To evaluate
the role of this rearrangement and other sequence differences at the *yellow* locus, we
proceeded to build chimeric constructs between *y5 bia* and *y5 pros*, and tested their activities
with reporter constructs in transgenic *D. melanogaster*. We expected that a sequence
segment with differential activity would reveal the location of changes between species.
We parsed y5' region into 6 segments, *I* to *VI*, with breakpoints in conserved blocks of
sequence (Fig. 4A), and derived 10 chimeric constructs (Fig. 4B). A first series (*PB1-PB5*)
has distal segments from *D. prostipennis* and proximal segments from *D. biarmipes*. A
second series (*BP1-BP5*) has the inverse configuration. All constructs are compared to the
parental constructs, *y5 bia* and *y5 pros*. The activities across the chimeric series transition
from a full *y5 bia*-like to a full *y5 pros*-like intensity (Fig. 4C and Fig. S4), although not
regularly. To precisely evaluate how each segment contributes to the activity of the
respective species, we derived maps of the expression fold change between consecutive
constructs (*log(construct(n)/construct(n+1*)) for the *BP* series and
*log(construct(n+1)/construct(n*)) for the *PB* series, Fig. 4D, see methods). These maps
confirm that each segment contributes a regulatory difference between *y5 bia* and *y5 pros*.
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They also indicate that some segments contain activation inputs while other are repressive, pointing to the lack of strict directionality in the evolution of the regulatory activities. Finally, some segments have a uniform effect on expression across the wing, while others have a local influence. The local effects could result from spatial patterning inputs, while global changes may be due to an overall modulation of DNA accessibility. In this respect, we noted an inconsistency between the *BP* and the *PB* series regarding the swap of segment *III*. Indeed, segment *III*, which contains part of the *spot*¹⁹⁶ core in both species, has opposite effects depending on the context. *III*ᵇia increases expression in the spot region in one series (Fig. 4B, compare *PB2* to *PB3*) and decreases it to levels even lower than *y5*⁵*pros* in the other series (Fig. 4B, *BP2* to *BP3*). To understand the origin of this inconsistency, we further dissected segment *III* with additional constructs with boundaries in this segment (Fig. S5). Notably, we found that the *spot* activity was mostly lost when we swapped a small segment immediately upstream *spot*¹⁹⁶ (Fig. S5, *BP2.1* to *BP2.2*). In the light of rearrangements of this enhancer core, we submit that *BP2.2* misses key regulatory information from both species to make the region accessible (33). Its weak regulatory activity, in spite of abundant activation inputs from surrounding sequence (Fig. S2, regulatory information loss from *B1* to *B7*, or *P1* to *P7*) may be explained by a disrupted enhancer core. Altogether, our data show that all segments of the *y5'* region contribute to differences in regulatory activity, although to variable extent, indicating that evolutionary changes are distributed across the entire regulatory region and suggesting that they have accumulated progressively. We concluded that the evolutionary diversification of *yellow* expression, and thereby of pigmentation intensity between species, evolved through many *cis*-regulatory mutations with additive quantitative effects.

## Discussion

Five types of evolutionary transitions drive the diversity of morphology that naturalists have described and documented for three centuries: the emergence of novel traits in lineages where these traits did not exist; changes in shape or spatial pattern; changes in size; changes in trait properties; and secondary loss of a trait. The genetic origin of these transitions has been abundantly dissected by evolutionary developmental biologists since the 1990s, with the exception of changes in trait properties. The continuous nature of these changes has been a serious challenge to tackle their genetic bases. Quantitative geneticists, however, have successfully showed that the genetic architecture of such variation among species often entails tens to hundreds of loci. When the trait is systemic, such as height in Humans, or an enzymatic activity easily quantified in a biochemistry assay, the description of phenotypes is straightforward. When the variation concerns an attribute of a trait, which may itself vary in many ways across species, including spatially, the analysis becomes complex. Researchers typically resort to arbitrary classes assessed by the experimenter (36, 37), which makes genetic mapping possible, but introduces biases. In addition, this makes it difficult to dissect the contribution of single loci among the many loci that collectively produce variation, because the phenotypic effects are too subtle to be assessed by visual inspection.

Yet, quantitative and continuous variation in the attributes of discrete morphological traits drive the diversification of the living world, and are best illustrated by the variation in hue of pattern elements in birds, fish, butterflies, or flowers. Because of their experimental suitability, we have examined the evolutionary origin of such quantitative variation among fruit fly species, taking advantage of the relative stability of their wing shape, contrasting with abundant variation in pigmentation patterns and levels (38). Focusing on darkness variation in a pattern element, a wing spot, we have quantified the continuous variation of
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this property among closely related species. Turning to the contribution of one of the loci
underlying this variation, *yellow*, we have showed that the amount of *yellow* expression
prefigures the extent of darkness on the wing. Finally, we have mapped the origin of this
variation to distributed changes across *yellow* regulatory region, presumably along a
known wing regulatory element, the *spot* enhancer (33). The strong correlation that we
observed between the strength of *yellow* regulatory alleles tested in *D. melanogaster* and
pigmentation intensity of the respective species suggests that these alleles are not sensitive
to the genomic context. In other words, the contribution of this region to pigmentation
intensity appears to be independent from other genes contributing to pigmentation. *D.
elegans* is a notable exception, as its regulatory region tested in a heterologous context is
weak compared to that of other species with very dark spots. We speculate that some key
regulators of *yellow* may have changed between the two species.

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Beyond gains and losses of discrete pattern elements, our work illustrates how the
diversification of a morphological trait can result from quantitative modulation of
attributes of this trait. While other network components undoubtedly influence
pigmentation intensity (36, 37, 39, 40), our study highlights the remarkable ability of a
single regulatory region to repeatedly and gradually modulate trait attributes via small
effect mutations over evolutionary times, as a quantitative dial.

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# Materials and Methods

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## Fly cultures

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Flies were raised in a climate chamber at 20°C on standard cornmeal medium. Stocks
were obtained from the Bloomington Drosophila Stock center (y[1] M{vas-int.Dm}ZH-2A
w[*]; PBac{y[+]-attP-3B}VK00016), from the San Diego Drosophila Species Stock
Center (now National Drosophila Species Stock Center: *D. biarmipes* #14023-0361.00; *D.
elegans* #14027-0461.03; *D. fuyamai* #14029-0011.00; *D. prostipennis* #14022-0291.00)
or from colleagues (*D. carrolli*, *D. suzukii*: genome line WT3 from A. Kopp; *D.
kurseongensis*, *D. prolongata*, *D. rhopaloa* from T. Matsuo). We used *D. ananassae*; *D.
eugracilis* and *D. melanogaster* Oregon R from our own collection.

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## Transgenesis

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Fly were transformed as in (20). In *D. melanogaster*, reporter constructs were transformed in *y*[1] *M{vas-int.Dm}ZH-2A w[*]; PBac{y[+]-attP-3B}VK00016* using the *ΦC31* system (41).

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## Adult wing imaging

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Wings of 5-day old males raised at 20°C were mounted as in (20) and imaged under a
Leica Macroscope equipped with a Manta G-609B/C camera (GigE camera with Sony
ICX694, Allied Vision, Exton, PA) driven by nVision software (Impuls Imaging GmbH,
Türkheim) using a diffuse back lighting table (DBL-2020-WT, MBJ Imaging, Hamburg)
for illumination. Images of wings that were broken, damaged or folded were excluded
from the analysis. The number of images analyzed per species were as follows: *D.
eugracilis*, 48; *D. biarmipes*, 43; *D. suzukii*, 54; *D. prostipennis*, 40; *D. elegans*, 50; *D.
fuyamai*, 50; *D. kurseongensis*, 52; *D. prolongata*, 47; *D. rhopaloa*, 50; *D. carrolli*, 50; *D.
ananassae*, 42. Each image represents a biological replicate of the experiment.

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## Immunohistochemistry

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Wild-type flies were raised in large vials under non-crowding conditions. Newly eclosed
males were collected every 30 minutes, precisely staged using morphological criteria, and
immediately frozen at -20°C until dissection. A single wing of each frozen fly collected on
the same day was dissected, and wings were arrayed on a smooth surface (the paper
protection of double-sided tape), transferred to a glue-coated microscope slide (double-
sided tape dissolved in heptane, spread on a slide and left to dry). To expose cells to the
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antibody, wings were split open as in (20). The dorsal wing side was fixed for 45 minutes at room temperature in fresh 5 % (v/v) PFA (Roti-Histofix) in PBT (Phosphate-buffered Saline, Gibco + 0.3 % (v/v) Triton-X, Sigma-Aldrich), then washed in PBT (3 x 10 minutes, several times shortly), covered with 1 ml of anti-Yellow antibody solution (polyclonal rabbit anti-Yellow antibody diluted 1:100 in PBT (28)) and incubated overnight at 4°C. The next day, the half wings on slides were washed extensively, then covered with 1 ml of secondary antibody solution (goat anti-rabbit Alexa Fluor 568 conjugate, Invitrogen #A11011, diluted 1:300 in PBT) for 1 h, washed again, and mounted with spacer in Vectashield (Vector Labs) for imaging.

## Fluorescent reporter sample preparation

For each reporter line, males with a single copy of the transgene were used for reporter expression quantification. Wings of post-eclosion males were dissected and mounted on a glue-coated slide (see Immunohistochemistry above), but were not split open. Slides with mounted wings were fixed for 45 minutes at room temperature in 4 % PFA in PBT, washed 30 minutes at room temperature in PBT, washed a second time overnight at 4 °C in PBT, and mounted in Vectashield (Vector Labs) as described above.

## Fluorescent imaging

Images of post-eclosion wings (for both antibody staining and reporter assays) were acquired as 16-bit images on a Ti2 Eclipse Nikon microscope equipped with a Nikon 10× plan apochromatic lens (numerical aperture, 0.45; Nikon Corporation, Tokyo, Japan) and a pco.edge 5.5 Mpx sCMOS camera (PCO, Kelheim, Germany) under illumination from a Lumencor SOLA SE II light source (Lumencor, Beaverton, OR, USA). Each wing was imaged by tiling and stitching of several z-stacks (z-step, 4 µm) with 50% overlap between tiles. Each image comprises a fluorescent channel (ET-DsRed filter cube, Chroma Technology Corporation, Bellows Falls, VT, USA) and a bright-field channel (acquired using flat field correction from the Nikon NIS-Elements software throughout), the latter being used for later image alignment. To ensure that fluorescence measurements are comparable between imaging sessions, we used identical settings for the fluorescence light source (100% output), light path, and camera (20-ms exposure time, no active shutter) to achieve comparable fluorescence excitation as in (33). Images of wings that were broken, damaged or folded were excluded from the analysis. The number of antibody staining images analyzed per species were as follows: *D. biarmipes*, 58; *D. suzukii*, 31; *D. prolongata*, 49; *D. elegans*, 36; *D. fuyamai*, 21; *D. kurseongensis*, 15; *D. prostipennis*, 25. The number of reporter assay images analyzed per species were as follows: first, for y5' constructs: *D. eugracilis*, 29; *D. biarmipes*, 43; *D. suzukii*, 48; *D. prostipennis*, 50; *D. elegans*, 52; *D. fuyamai*, 50; *D. kurseongensis*, 40; *D. prolongata*, 37; *D. rhopaloa*, 39; *D. carrolli*, 34; *D. ananassae*, 50. Then for chimeric constructs: *BP1*, 27; *BP2*, 27; *BP3*, 25; *BP4*, 25; *BP5*, 24; *PB1*, 10; *PB2*, 6; *PB3*, 7; *PB4*, 14; *PB5*, 13; *BP2.1*, 17; *BP2.2*, 10; *BP3.1*, 14; *BP3.2*, 11; *B1*, 23; *B2*, 14; *B3*, 28; *B4*, 16; *B5*, 13; *B6*, 10; *B7*, 9; *P1*, 10; *P2*; 23; *P3*, 28; *P4*, 22; *P5*, 12; *P6*, 13; *P7*, 7; y5<sup>bia</sup>, 13; y5<sup>pros</sup>, 20; Φ (empty vector), 23. Each image represents a biological replicate of the experiment.

## Image quantitative analysis

**Fluorescent image Projection.** Three-dimensional stacks were projected to two-dimensional (2D) images for subsequent analysis using a maximum sharpness z-projection defined on the transmitted light images acquired alongside fluorescence images. The average local sharpness of the transmitted light channel was calculated for every pixel position within each z slice. Subsequently, a 2D map indicating the slice index with the highest sharpness was generated and then smoothed using a Gaussian kernel (with a sigma of 5 pixels). The resulting reconstituted 2D images encompassed both bright-field and fluorescent data, with the value of the sharpest slice assigned to each pixel.
*Image Registration.* To align reporter fluorescence images and antibody fluorescence images with a reference wing, we employed a registration process that leverages transmitted light images acquired alongside fluorescence images. Our custom image registration software (https://github.com/LMU-AgGompel/Image-registration-gui), coded in Python, allows both manual and automated registration procedures. This software features an intuitive graphical user interface (GUI) that empowers users to pinpoint corresponding landmark points within each dataset image. Notably, these landmarks can be positioned manually by the user or automatically detected through a convolutional neural network (CNN). The images in the present paper were registered using the version of the code of March 2nd 2023. Nevertheless, the latest version of the code is better annotated and contains additional features.

For manual landmark definition, users can select through the GUI identifiable points such as vein intersections on the wing. The relative positions of these selected landmarks serve as the foundation for executing elastic image registration, which employs a thin-plate-spline registration algorithm.

To further enhance registration quality, we incorporated additional automatically detected "sliding landmarks". We define sliding landmarks as equidistant points positioned along prominent features like edges and bright or dark ridges, connecting two primary landmark points.

The automated detection of sliding landmarks is based on an active-contour fitting method on a pre-processed version of the image where edges are enhanced. Such pre-processing consists of a difference of Gaussians algorithm, followed by Otsu thresholding and the removal of minor connected components from the resulting binary image. Subsequent steps involve distance transformation and normalization, yielding an energy map for active contour fitting. The active contour fitting process is designed to minimize a function incorporating both external and internal energies. The external energy is derived from the energy map, while the internal energy is governed by the contour average curvature, the average spacing between contour nodes, and the variance of spacing between consecutive nodes. A balance between internal and external energies is maintained through a parameter, alpha, set consistently to 0.1 for all contours. This approach results in smooth contours with uniformly spaced nodes.

For automated detection of primary landmarks, a convolutional neural network (CNN) is employed, inspired by models tailored for facial landmark detection. The network architecture includes stacked Convolution2D layers with a LeakyReLU activation, a BatchNormalization, and a MaxPooling layer. The number of filters progressively increases in subsequent convolutional layers (32, 64, 96, 128, 256, and 512), while reducing the spatial dimension of the feature vector. This design facilitates the learning of intricate and abstract features throughout the network's layers. After the convolutional layers, a dense layer with 512 neurons acts as a feature bottleneck before the final output layer, which provides directly the x and y coordinates of the main landmark points.

The CNN was trained on a meticulously annotated dataset of 1000 wings using fourteen landmarks placed on vein intersections and end points. All manually annotated landmark positions were reviewed by a second experimenter. To augment the dataset, diverse transformations were applied, including random rigid rotations, rescaling, and the addition of Gaussian noise. This augmentation resulted in a dataset 64 times its original size. The CNN model trained on this dataset demonstrates a relative precision of approximately 0.5% in landmark positioning compared to the overall wing size, akin to the precision achieved through manual annotation.

*Average phenotype images.* For adult wing pigmentation intensity quantification, individual registered images were converted to grayscale by eliminating hue and
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saturation information while retaining the luminance. For Yellow protein quantification, a *D. melanogaster yellow* null mutant was stained and used as a control for background signal. The median of all control images was subtracted from each image in the dataset to baseline the data. Partially damaged wings were included in the final dataset after masking out damaged parts of the wings with manually designed binary masks. For reporter expression quantification of all transgenic flies, a transgenic line with an empty reporter vector (ø) was used as a proxy to measure noise and tissue autofluorescence. The median raw fluorescent image was computed across all ø images and used to remove autofluorescence, subtracted from all raw images before the following steps. Average wing images were computed as the average smoothed fluorescence intensity at every pixel among all individuals in a given group. Color map 'Magma' was used to represent the average phenotypes.

*Intensity frequency histograms.* Histograms were calculated for each image by binning all intensity values within the analysis mask in 256 equally spaced intervals between (m1 – k) and (m2 + k) (where m1 and m2 are the minimum and maximum intensity values in the whole dataset and k = (m2 - m1) * 0.01). Counts per bin were divided by the total number of pixels per mask to obtain frequency histograms. All histograms were smoothed with discretized spline smoothing in order to obtain density plots. Since low values constitute the majority of the image, density plots were logarithmically transformed according to $f = \log_{10}(1 + K * f)$ where f are the individual frequency values from the density plots and k is a constant (K = 1000 for average density plots). The mean intensity per species is the average intensity of all analyzed pixels for each individual image, averaged by species.

*Bivariate scatter plots.* For the bivariate scatter histograms, the pixel values of average wing images obtained from adult wing imaging and Yellow antibody staining for each species were treated as coordinate pairs in a cartesian coordinate system. x coordinate corresponds to Yellow signal intensity and y coordinate represents pigmentation intensity for each species.

*LogRatio.* The phenotype comparison between consecutive constructs of the *BP* and *PB* series was represented by *logRatios* of a phenotype relative to another. The *logRatio* between two constructs is calculated as the pixel-by-pixel logarithm of the ratio between the two phenotypes, as described in (34). *logRatio* images were represented using color map 'RdBu'.

*Overall regulatory information loss.* The overall amount of regulatory information lost in successive fragments for *B* and *P* series was approximated to the phenotypic distance to the respective largest fragment (*y5''bia* for the *B* series, *y5''pros* for the *P* series) in PCA space, divided by the phenotypic distance between the largest construct of the series and the empty construct (ø) for normalization purpose, similarly to what we described in (33).

## Statistical analysis

The correlations in the scatter plots were measured with a simple linear regression by using ordinary least squares (OLS) estimation in Python (version 3.8.3). PCA was used to remove correlation between pixel intensities, to concentrate the variance on few variables, and therefore, to describe the variation in intensity and pattern of reporter gene expression in a comprehensive and unbiased way with few dimensions, as described in (33). PCA was calculated on the matrix regrouping intensities of all pixels for every individual, of dimensions (n\_individuals × n\_pixels on the wing). The transformed images are quantitatively comparable and the significance of the difference between two constructs was examined by a multidimensional Kolmogorov-Smirnov two-sample test on the first two PCA components (42) (Table S3).

## Molecular biology
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Cloning. All primer sequences are listed in table S1. Reporter constructs (listed in table S2, full insert sequences in Text S1) were generated by cloning non-coding DNA fragments from the 5' region of the *yellow* gene (*y5*') into the ΦC31-compatible vector pRedSA (a DsRed reporter vector derived from pRed H-Stinger (43)) using the commercial In-Fusion system (Clonetech). pRedSA vector was first linearized with BamHI-HF and EcoRI-HF (New England Biolabs). The regulatory fragments were amplified from genomic DNA of different species, using primers that attach 15 bp of sequence complementary to ends of the linearized vector to both sides of the fragments, as required by the In-Fusion system. The 5' primer (#195 in table S1) was designed to match 19 bp of sequence 100% conserved in all species (with the exception of *D. ananassae*), located 5 to 7 kb upstream of the *yellow* TSS, within the coding region of the orthologs of CG43182, the next ORF upstream of the *yellow* gene in *D. melanogaster* (44). For the *y5'* *biarmipes* and *y5'* *eugracilis* regions, different 5' primers were used, binding 16 bp (*biarmipes*) and 14 bp (*eugracilis*) upstream of the universal primer #195 used for all other constructs. 3' primers were species-specific and designed to exclude elements of the highly conserved *yellow* core promoter, such as the TATA-box and the Initiator, that were predicted using the online tool ELEMENT (http://lifefaculty.biu.ac.il/gershon-tamar/index.php/element-description/element) (45).

## Sequence alignment and normalization

For *y5'* regulatory region comparison between *Drosophila* species, BLASTn was run and alignments were visualized in R by using "genoPlotR" package (46). Because all reporter constructs are of different lengths (5-7 kb), we normalized the schematic representation of all sequences for better visualization rather than sketching their actual length. In Fig. 4, *y5*<sup>bia</sup> (5317 bp) and *y5*<sup>pros</sup> (6270 bp) were first normalized to 10 000 bp. All segments were then scaled up proportionally. For instance, *I*<sup>bia</sup> (793 bp) and *I*<sup>pros</sup> (965 bp) were normalized to 1491 bp and 1539 bp respectively. *PB* and *BP* series were both normalized accordingly.

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## Acknowledgments

We are grateful to Lena Osipova, Rita Jaenichen, Joel Eggert and Nazlı Akili for technical assistance. We thank Yann Le Poul, Krushnamegh Kunte and Artyom Kopp for discussions and ideas during the early phase of this project, and Luisa Pallares for constructive feedback on the manuscript. We also acknowledge Artyom Kopp, Takashi Matsuo, the *Drosophila* Species Stock Center (Cornell University) and Flybase for fly stocks and information on *Drosophila* genomes.

**Funding:** This work was supported by the Ludwig-Maximilians University of Munich, the Graduate School Life Science Munich (LSM, to K. B. and X. L.), the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013) / ERC Grant Agreement n° 615789 (to B.P.), the Erasmus Mundus Master Programme in Evolutionary Biology (MEME, to Blair Matarlo) and the Deutsche Forschungsgemeinschaft (grants INST 86/1783-1 LAGG, and GO 2495/10-1 to N. G.; Project number 422857584 to HH and HL).

**Author contributions:** N.G., B.P. and L.A. conceptualized the project; K.B. designed and performed the antibody staining experiments, the measurement of pigmentation intensity and a large part of the reporter assays. X.L. contributed another large part of the reporter assays, including the design, cloning and imaging of the chimeric constructs. S.W. and Blair Matarlo cloned and imaged several reporter constructs and carried out sequence analyses and sequence comparison. K.B., X.L. and S.C. analyzed the data and generated all figures. Bettina Mühling. and X. L. produced all transgenic lines; D.H., H.H. and H.L. supported the design of an automated imaging set-up, including the programming of a microscope driver. S.C.developed and implemented a pipeline for image registration and analysis; K.B., X.L., S.C. and N.G. interpreted the data. N.G. and X.L. wrote the manuscript, with feedback from all authors. N.G. supervised the project; N.G. and B.P. acquired funding.

**Competing interests:** Authors declare that they have no competing interests.

**Data and materials availability:** All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials.

## Figures legends
**Fig. 1. Quantitative variation of wing pigmentation among closely related *Drosophila*.*

(A) *Drosophila* species in the *D. melanogaster* group (tree on the left) are decorated with distal wing pigmentation pattern (first column). Each colored wing (second column) is an average of ~25 of aligned adult wings of the same species, with a colormap reflecting pigmentation intensity. The amount of dark pigmentation varies across the wing blade, but the distribution is stable within species (histograms of third column). In the histograms, average maximum and average minimum intensity values per species are indicated by vertical black, solid lines. The average histogram is shown in the colored region with black outline. Grey solid lines delineate the minimum and maximum histograms per species and indicate the range of intraspecies intensity variation. Green horizontal dashed lines are the frequency thresholds for determining the range. (B) Maximum pigmentation intensity (distal pattern element) varies quantitatively in a continuum among these species, while minimum pigmentation intensity (background color) is relatively stable and not correlated with maximum pigmentation intensity. Maximum pigmentation intensity was calculated by averaging intensity in a region of the wing with the darkest 5% of pixels in the pigmentation image. Minimum pigmentation was represented by averaging intensity of the lightest 5% of pixels in the pigmentation image.

**Fig. 2. Quantitative changes in yellow expression correlate with wing pigmentation intensity. (A to G) Bivariate scatter plots illustrating the relationship between Yellow protein levels (Yellow antibody fluorescence intensity, x-axis) and corresponding pigmentation intensity (y-axis) for seven *Drosophila* species. Each point in the graphs represents a corresponding pixel on the anti-Yellow staining wing and the average adult wing registered images, respectively. Yellow dots are pixels in wing veins and darker blue dots are pixels in the wing blade. Magenta lines show ordinary least squares regression lines. The wings next to each axis are averages of many individual wing images of corresponding species (see methods). Colormaps are indicated to the left and to the bottom of the figure. (H) Left: maximum level of pigmentation and corresponding Yellow expression in average wing phenotypes of each species. We selected a region of the wing with the darkest 5% of pixels in the pigmentation image and calculated the average intensity values of this region to represent the maximum pigmentation of the wing. Average Yellow levels of the same region were also measured, indicating that species with darker pigmentation in the wing also exhibit higher Yellow expression levels. Right: the average darkest 5% pigmentation with the slope of pigmentation versus Yellow for each species. The slope values were obtained from the magenta regression line in (A to G), suggesting that different species respond differently to Yellow protein level.**
<caption>**Fig. 3. Regulatory changes at the *yellow* locus modulate expression levels in the wing.**</caption>

(A) Map of the *yellow* locus with a schematic of the region (y5') upstream of the *yellow* TSS tested in reporter assays. (B) Average reporter activity of y5' from various species (tree on the left) in the wing of *D. melanogaster* transgenics. The different alleles result in strikingly different levels of reporter expression (middle: average wings, right: histograms). Histograms are annotated as in Fig. 1A, with average maximum and average minimum expression levels instead of pigmentation. Here and in all subsequent figures, ø denotes a transgenic line with an empty reporter vector. (C) The maximum of y5' regulatory activity correlates with the maximum of wing pigmentation intensity of their respective species of origin. Of note, *D. elegans* is an outlier. The discrepancy between reporter expression and Yellow protein levels (Fig. 2D) suggests that *yellow* expression may also be controlled by additional *cis*- and *trans*-regulatory mechanisms.

<caption>**Fig. 4. Distributed regulatory changes upstream of *yellow* explain the activity difference between the pale *D. prostipennis* and the dark *D. biarmipes*.**</caption>

(A) An alignment of y5' region between *D. biarmipes* (*bia*) and *D. prostipennis* (*pros*) reveals that most of the sequence shows over 70% similarity. Of note, the core of the *spot* enhancer, *spot*¹⁹⁶, as we previously defined it in *D. biarmipes* (33), is only partially conserved and duplicated in *D. prostipennis*. We parsed the region into 6 arbitrary segments of comparable sizes (*I-VI*) with boundaries in blocks of high sequence conservation to design chimeric constructs. (B) Chimeric constructs with a distal *D. prostipennis* segment and a proximal *D. biarmipes* segment (*PB*) or reciprocally (*BP*). Sequence length (including *y5 pros* and *y5 bia*) was normalized to 10 kb to facilitate comparison, and subsequently the length of each segment (*I-VI*) was adjusted in equal proportion (see details in the methods). (C) Average wing reporter activity of all constructs shown in (A) and (B). (D) Maps of reporter expression fold changes in the wing between selected constructs (log scale) indicate the amount of regulatory information changes brought by each segment between *D. biarmipes* and *D. prostipennis*.

**Supplementary Materials**

Figs. S1 to S3

Tables S1 to S3

Table S1. Primer list.

Table S2. List of constructs for transgenesis.

Table S3. Significance of pairwise comparisons between chimeric constructs

Text S1. Construct sequences (Insert).

Text S2. BLASTN alignment between *D. biarmipes* (*bia*) and *D. prostipennis* (*pros*)
A

<figure><img src="image_3.png" /></figure>

B

<figure><img src="image_4.png" /></figure>
PIGMENTATION INTENSITY

A

<figure><img src="image_5.png" /></figure>

B

<figure><img src="image_6.png" /></figure>

C

<figure><img src="image_7.png" /></figure>

D

<figure><img src="image_8.png" /></figure>

E

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F

<figure><img src="image_10.png" /></figure>

G

<figure><img src="image_11.png" /></figure>

H

<figure><img src="image_12.png" /></figure>

α-YELLOW SIGNAL INTENSITY
<figure><img src="image_13.png" /><figcaption>B</figcaption></figure>

<figure><img src="image_14.png" /><figcaption>C</figcaption></figure>

<figure><img src="image_15.png" /></figure>
<figure><img src="image_16.png" /></figure>

<figure><img src="image_17.png" /></figure>
Supplementary Materials for

**Regulatory evolution tuning pigmentation intensity quantitatively in**
*Drosophila*

**This PDF file includes:**

Figs. S1 to S3
Tables S1 to S3
Texts S1 and S2
<figure><img src="image_18.png" /><figcaption>Fig. S1. Conservation of y5' sequence among multiple species.</figcaption></figure>

The grey bars represent the y5' region of the corresponding species listed on the left in the phylogenetic tree. Blocks of sequence with at least 65% identity between species pairs along the tree are indicated by red-shaded areas. Mapped regulatory regions for *D. biarmipes* and *D. prostipennis* are marked with different colors (see inset).
<figure><img src="image_19.png" /><figcaption>Fig. S2. Comparative mapping of regulatory activities along *y*5' between *D. biarmipes* and *D. prostipennis*.</figcaption></figure>

(A) Map of the *yellow* locus with a schematic of the region (*y*5') upstream of the *yellow* TSS tested in reporter assays. (B) *B*-series of fragments derived from *y*5' region of *D. biarmipes* were tested in reporter assays and the overall loss of regulatory information along the sequence were calculated. This series was previous examined (4) and re-imaged here. The area shaded in purple
identifies a previously studied regulatory component (4), *spot*¹⁹⁶ in *D.biarmipes*. (C) An alignment of *y5'* region between *D. biarmipes* (*bia*) and *D. prostipennis* (*pros*). Of note, the core of the *spot* enhancer, *spot*¹⁹⁶, as we previously defined it in *D. biarmipes* (4), is only partially conserved and duplicated in *D. prostipennis*. (D) P-series of fragments derived from *y5'* region of *D. prostipennis* were tested in reporter assays and the overall loss of regulatory information along the sequence were calculated. This series was designed as ortholog to *D. biarmipes* B-series; The area shaded in purple slash pattern represents predicted orthologous *spot*¹⁹⁶ sequences in *D. prostipennis*. (E) Images of average reporter expression of all individuals for each construct in the wing according to the color map below.
<figure><img src="image_20.png" /><figcaption>Fig. S3. Sequence conservation and divergence within *spot*<sup>196</sup> enhancer core.</figcaption></figure>

(A) An alignment of y5' region between *D. biarmipes* and *D. prostipennis*. *spot*<sup>196</sup> defined in *D. biarmipes* (4) and its ortholog in *D. prostipennis* are indicated. (B) An alignment of *spot*<sup>196</sup> region between *D. biarmipes* and *D. prostipennis*. A 128-bp distal segment of *D. biarmipes* *spot*<sup>196</sup> aligns well with a 91-bp segment of *D. prostipennis*, while the remaining 68 bp of *D. biarmipes* *spot*<sup>196</sup> do not appear to have orthologous sequences in *D. prostipennis*. Notably, the conserved 91-bp *spot*<sup>196</sup> ortholog is duplicated in tandem in *D. prostipennis* in a 129-bp upstream segment. (C) Sequence details of the schematic shown in (B). Orange shading denotes sequence identity. The dark red * denotes where the alignment of the duplicated spot region starts.
<figure><img src="image_21.png" /><figcaption>Fig. S4. Variation of reporter expression among individual wings and transgenic lines of chimeric constructs of the *BP* and *PB* series.</figcaption></figure>

Principal component analysis of *yellow* enhancer activity variation in the two chimeric construct series. (A) Variation in PC1 and PC2 within the *BP*-series dataset. (B) Variation in PC1 and PC2 within the *PB*-series dataset. Colored cluster plots correspond to the first two principal component scores of each construct, with dots representing individual wings. The center of a cluster represents the position of the phenotypic average of a construct within the coordinate system spanned by the principal components. Wing heat maps besides the axes graphically represent the loadings or PCA coefficients and indicate where intensity is increasing or (+) or decreasing (-) when progressing along the respective principal component. PC1 captures most of the variation and corresponds to overall changes in the activity of the spot region. PC2 appears to represent spatial difference in wing activity between lines.
<figure><img src="image_22.png" /><figcaption>Fig. S5. Fine mapping of regulatory information in the *spot*<sup>196</sup> enhancer core.</figcaption></figure>

(A) An alignment of y5' region between *D. biarmipes* (*bia*) and *D. prostipennis* (*pros*), as presented in Fig. 4a, shows that *spot*<sup>196</sup> is only partially conserved and its distal half is duplicated in *D. prostipennis*. (B) Chimeric constructs with boundaries in and around *spot*<sup>196</sup> enhancer core with a distal *D. biarmipes* segment and a proximal *D. prostipennis* segment (BP). BP2, BP3 and BP4 are already described in Fig. 4. BP2.1, BP2.2 and BP3.1 are additional constructs with intercalary boundaries (each marked with an asterisk). (C) average wing reporter activity of all constructs shown in (A) and (B).
<table><caption>Table S1. Primer list</caption><thead><tr><th>identifier</th><th>Sequence (5' to 3')</th><th>Use</th></tr></thead><tbody><tr><td colspan="3">y5' region</td></tr><tr><td>#34</td><td>gagcccgggcgaattCAAGAGCCCAAGGTCGGT</td><td>y 5'bia fw</td></tr><tr><td>#38</td><td>gagcccgggcgaattAGAACCCAAGGGCGCT</td><td>y 5'eu fw</td></tr><tr><td>#137</td><td>gctcctcgagggatCTGCTTTCGGTGGCTCGGG</td><td>y 5'bia rv</td></tr><tr><td>#138</td><td>gctcctcgagggatCTGGTTTCAGCGGTTCGGGTG</td><td>y 5' eu rv</td></tr><tr><td>#189</td><td>gctcctcgagggatGAGCTTTTCGGTGGTg</td><td>y 5' prol rv</td></tr><tr><td>#190</td><td>gctcctcgagggatCTGGTTTCAGTGGTTCGGC</td><td>y 5' pros rv</td></tr><tr><td>#195</td><td>gagcccgggcgaattAACCTACCCATCCAGCTGG</td><td>y 5' universal fw</td></tr><tr><td>#205</td><td>gctcctcgagggatCTGGTGGTTTCAGTGATTCGG</td><td>y 5' suz rv</td></tr><tr><td>#222</td><td>gctcctcgagggatGACGAAGACTTGGGCCAATG</td><td>y 5' taka rv</td></tr><tr><td>#223</td><td>gctcctcgagggatAGAegaagacaggccaatga</td><td>y 5' ele rv</td></tr><tr><td>#224</td><td>gctcctcgagggatAGGCCAATGGAAACGACAAC</td><td>y 5' rho rv</td></tr><tr><td>#226</td><td>gctcctcgagggatAGACGAAGACAGGCCAATGG</td><td>y 5'carr rv</td></tr><tr><td>#249</td><td>gctcctcgagggatcgctccaagcgaaaagaaacc</td><td>y 5'ana rv</td></tr><tr><td>#250</td><td>gagcccgggcgaattgaaactaccatccaacaccg</td><td>y 5'ana fw</td></tr><tr><td>#254</td><td>gctcctcgagggatCAGGCCAATAGAAACGAAAACG</td><td>y 5' fuya rv</td></tr><tr><td colspan="3">B-series</td></tr><tr><td colspan="3">P-series</td></tr><tr><td>P0</td><td>gagcccgggcgaattAACCTACCCATCCAGCTGG</td><td>P0fw</td></tr><tr><td>P1</td><td>gagcccgggcgaattGCAATCACTTCAATTTCGGTT</td><td>P1fw</td></tr><tr><td>P2</td><td>ctagagcccgggcgaattTCCTTAGTTCAGAAAGTATTAGCT</td><td>P2fw</td></tr><tr><td>P3</td><td>ctagagcccgggcgaattATTAATCGATTATCGCCCG</td><td>P3fw</td></tr><tr><td>P4</td><td>ctagagcccgggcgaattTTGCTTAGTTTACTTTTCGCGC</td><td>P4fw</td></tr><tr><td>P5</td><td>gagcccgggcgaattTGACATGATACGCGTTAT</td><td>P5fw</td></tr><tr><td>P6</td><td>ctagagcccgggcgaattGAAATCTCCGCGGCTTGT</td><td>P6fw</td></tr><tr><td>P7</td><td>ctagagcccgggcgaattTGCTAGCGCTGAAATCTTT</td><td>P7fw</td></tr><tr><td>P-rev</td><td>gctcctcgagggatCTGGTTTCAGTGGTTCGGC</td><td>P_seriesReverse</td></tr><tr><td colspan="3">Chimeric</td></tr><tr><td>BP1_pros</td><td>TCAATAAACGATAGTCAAGCCAAGAG</td><td>BP1_prosfw</td></tr><tr><td>BP1_bia</td><td>actatcgtttattgaTTTCCTGGTGAAAAGCAGTTGCT</td><td>BP1_biaRV</td></tr><tr><td>BP2_pros</td><td>CCTTAGTTCAGAAAGTATTAGCTTTTCATG</td><td>BP2_prosfd</td></tr><tr><td>BP2_bia</td><td>ctttctgaaactaggATAATTGTCCATTAAACAACCCGAACT</td><td>BP2_biaRV</td></tr><tr><td>BP3_pros</td><td>ATTTAACGAATTCCTTGTCGACTATTTAAATAC</td><td>BP3_prosfw</td></tr><tr><td>BP3_bia</td><td>aggaattcgttaaatTTATTCAAGCCAAAAGCGGGGAAATTT</td><td>BP3_biaRV</td></tr><tr><td>BP4_pros</td><td>TTATTGGGAAAAGCGCGTATAAATC</td><td>BP4_prosfw</td></tr><tr><td>BP4_bia</td><td>ATTAGAGCATTACCCACTTAGGG</td><td>BP4_biaRV</td></tr><tr><td>BP5_pros</td><td>cgcttttccaataaTTGAAACGAGTTTGTCCCGGC</td><td>BP5_prosfw</td></tr><tr><td>BP5_bia</td><td>gggtaatgctctaatGGCCATGGCCGCAAG</td><td>BP5_biaRV</td></tr><tr><td>Bia_start</td><td>gagcccgggcgaattCAAGAGCCCAAGGTCGGTC</td><td>BP_bia_allfw</td></tr><tr><td>Pros_end</td><td>cgctcctcgagggatCTGGTTCCAGTGGTTCGGC</td><td>BP_pros_allRV</td></tr><tr><td>PB1_bia</td><td>cttttcaccaggaaaTCAATAAACGCTCGTCCA</td><td>PB1_biafw</td></tr></tbody></table>
<table><tr><td>PB1_pros</td><td>tttcctggtgaaaagCTGTATTTGCTGCTGC</td><td>PB1_pros_rv</td></tr><tr><td>PB2_bia</td><td>gttcagaaagcgcctGCCTTTATGCGTATTTCC</td><td>PB2_biafw</td></tr><tr><td>PB2_pros</td><td>aggcgctttctgaacTAAGGATAATTGATCGT</td><td>PB2_pros_rv</td></tr><tr><td>PB3_bia</td><td>tctaaatttctcttgTTTTGGCTTGAATAAATTAATCG</td><td>PB3_biafw</td></tr><tr><td>PB3_pros</td><td>caagagaaatttagaTCTCTCCTTAAATGTGTTT</td><td>PB3_pros_rv</td></tr><tr><td>PB4_bia</td><td>tgggaaaagcgcgtaTAAATCATCGCCGCCAAA</td><td>PB4_biafw</td></tr><tr><td>PB4_pros</td><td>tacgcgccttttccaATAATTGAAACGAGTTTGG</td><td>PB4_pros_rv</td></tr><tr><td>PB5_bia</td><td>cacttgccggcgatggCCATTAGAGCATTACCCACT</td><td>PB5_biafw</td></tr><tr><td>PB5_pros</td><td>ccatcgccgcaagtgAATGTGAAAATCCAAGA</td><td>PB5_pros_rv</td></tr><tr><td>Pros_start</td><td>gagcccgggcgaattAACCTACCCATCCAGCT</td><td>PB_pros_allfw</td></tr><tr><td>Bia_end</td><td>cgctcctcgagggatCTGCTTTCGGTGGCT</td><td>PB_bia_all_rv</td></tr></table>

<table><tr><td>BP2.1_pros</td><td>cgattatcgcccgattACCACATTGAGTGGCTT</td><td>BP2.1_prosfw</td></tr><tr><td>BP2.1_bia</td><td>aatcgggcgataatcgATAAGCAATCGCAGCGAT</td><td>BP2.1_biarv</td></tr><tr><td>BP2.2_pros</td><td>agcgccttgtattggCATCTTATTTGCGCCAT</td><td>BP2.2_prosfw</td></tr><tr><td>BP2.2_bia</td><td>ccaatacaaggcgcctGGCCGCTCACTGCGCAAA</td><td>BP2.2_biarv</td></tr><tr><td>BP3.1_pros</td><td>gtgcgcccatgcaatGCTTTGAAATCTTGTCTTT</td><td>BP3.1_prosfw</td></tr><tr><td>BP3.1_bia</td><td>attgcatgggcgcacATCAATTAGGCGGATT</td><td>BP3.1_biarv</td></tr><tr><td>BP3.2_pros</td><td>caggaaatctccgcgGCTTGTCTGATTTTGG</td><td>BP3.2_prosfw</td></tr><tr><td>BP3.2_bia</td><td>cgcggagatttcctgCTCGCAGGCGTGCACTG</td><td>BP3.2_biarv</td></tr></table>

Sequencing

<table><tr><td>B21_F</td><td>gcttggctgcatcacgtaat</td><td>pRedSA sequencing</td></tr><tr><td>B22_R</td><td>gtcctcgaagttcatcacgc</td><td>pRedSA sequencing</td></tr></table>
<table><caption>Table S2: List of constructs for transgenesis.</caption><thead><tr><th>Construct name</th><th>Insert (position relative to y TSS in donor species)</th><th>Cloning primers</th></tr></thead><tbody><tr><td>pRedSA-y 5<sup>′</sup>ana</td><td>D. ananassae y 5' region (-5634 to -59)</td><td>#250, #249</td></tr><tr><td>pRedSA-y 5<sup>′</sup>bia (B0)</td><td>D. biarmipes y 5' region (-5398 to -114)</td><td>#34, #137</td></tr><tr><td>pRedSA-y 5<sup>′</sup>car</td><td>D. carrolli y 5' region (-5513 to -49)</td><td>#195, #226</td></tr><tr><td>pRedSA-y 5<sup>′</sup>ele</td><td>D. elegans y 5' region (-5506 to -51)</td><td>#195, #223</td></tr><tr><td>pRedSA-y 5<sup>′</sup>eug</td><td>D. eugracilis y 5' region (-5038 to -102)</td><td>#38, #138</td></tr><tr><td>pRedSA-y 5<sup>′</sup>fuy</td><td>D. fuyamai y 5' region (-5474 to -61)</td><td>#195, #254</td></tr><tr><td>pRedSA-y 5<sup>′</sup>kur</td><td>D. kurseongensis y 5' region (-6150 to -43)</td><td>#195, #339</td></tr><tr><td>pRedSA-y 5<sup>′</sup>prol</td><td>D. prolongata y 5' region (-7226 to -117)</td><td>#195, #189</td></tr><tr><td>pRedSA-y 5<sup>′</sup>pros (P0)</td><td>D. prostipennis y 5' region (-6376 to -107)</td><td>#195, #190</td></tr><tr><td>pRedSA-y 5<sup>′</sup>rho</td><td>D. rhopaloa y 5' region (-5536 to -59)</td><td>#195, #224</td></tr><tr><td>pRedSA-y 5<sup>′</sup>suz</td><td>D. suzukii y 5' region (-5371 to -92)</td><td>#195, #205</td></tr><tr><td>pRedSA-y 5<sup>′</sup>tak</td><td>D. takahashii y 5' region (-6061 to -53)</td><td>#195, #222</td></tr><tr><td>pYellowSuz-y 5<sup>′</sup>car</td><td>D. carrolli y 5' region (-5474 to -49)</td><td>#321, #322</td></tr><tr><td>P-series</td><td></td><td></td></tr><tr><td>pRedSA_P1</td><td>D. prostipennis y 5' region (-4639 to -107)</td><td>P1, P_series</td></tr><tr><td>pRedSA_P2</td><td>D. prostipennis y 5' region (-4547 to -107)</td><td>P2, P_series reverse</td></tr><tr><td>pRedSA_P3</td><td>D. prostipennis y 5' region (-4235 to -107)</td><td>P3, P_series reverse</td></tr><tr><td>pRedSA_P4</td><td>D. prostipennis y 5' region (-3893 to -107)</td><td>P4, P_series reverse</td></tr><tr><td>pRedSA_P5</td><td>D. prostipennis y 5' region (-3469 to -107)</td><td>P5, P_series reverse</td></tr><tr><td>pRedSA_P6</td><td>D. prostipennis y 5' region (-2971 to -107)</td><td>P6, P_series reverse</td></tr><tr><td>pRedSA_P7</td><td>D. prostipennis y 5' region (-2364 to -107)</td><td>P7, P_series reverse</td></tr><tr><td>Chimeric constructs</td><td></td><td></td></tr><tr><td>pRedSA_BP1</td><td>D. biarmipes y 5' region (-5398 to -4635)</td><td>Bia_start, BP1_bia</td></tr><tr><td>pRedSA_BP2</td><td>D. biarmipes y 5' region (-5398 to -3476)</td><td>Bia_start, BP2_bia</td></tr><tr><td>pRedSA_BP3</td><td>D. biarmipes y 5' region (-5398 to -2750)</td><td>Bia_start, BP3_bia</td></tr><tr><td>pRedSA_BP4</td><td>D. biarmipes y 5' region (-5398 to -1960)</td><td>Bia_start, BP4_bia</td></tr><tr><td>pRedSA_BP5</td><td>D. biarmipes y 5' region (-5398 to -1060)</td><td>Bia_start, BP5_bia</td></tr><tr><td>pRedSA_BP5</td><td>D. biarmipes y 5' region (-5398 to -1060)</td><td>Bia_start, BP5_bia</td></tr><tr><td>pRedSA_BP1</td><td>D. prostipennis y 5' region (-6376 to -5411)</td><td>Pros_start, PB1_pros</td></tr><tr><td>pRedSA_BP2</td><td>D. biarmipes y 5' region (-4637 to -114)</td><td>Bia_end, PB1_bia</td></tr><tr><td>pRedSA_BP2</td><td>D. prostipennis y 5' region (-6376 to -4511)</td><td>Pros_start, PB1_pros</td></tr><tr><td>pRedSA_BP2</td><td>D. biarmipes y 5' region (-3473 to -114)</td><td>Bia_end, PB1_bia</td></tr></tbody></table>
<table><tr><td>pRedSAPB3</td><td>D. prostipennis y 5' region (-6376 to -3755)</td><td>Pros_start, PB1_pros</td></tr><tr><td></td><td>D. biarmipes y 5' region (-2752 to -114)</td><td>Bia_end, PB1_bia</td></tr><tr><td>pRedSA PB4</td><td>D. prostipennis y 5' region (-6376 to -2393)</td><td>Pros_start, PB1_pros</td></tr><tr><td></td><td>D. biarmipes y 5' region (-1962 to -114)</td><td>Bia_end, PB1_bia</td></tr><tr><td>pRedSA PB5</td><td>D. prostipennis y 5' region (-6376 to -1043)</td><td>Pros_start, PB1_pros</td></tr><tr><td></td><td>D. biarmipes y 5' region (-1062 to -114)</td><td>Bia_end, PB1_bia</td></tr><tr><td>pRedSA BP2.1</td><td>D. biarmipes y 5' region (-5398 to -3158)</td><td>Bia_start, BP1_bia</td></tr><tr><td></td><td>D. prostipennis y 5' region (-4237 to -107)</td><td>Pros_end, BP1_pros</td></tr><tr><td>pRedSA BP2.2</td><td>D. biarmipes y 5' region (-5398 to -2828)</td><td>Bia_start, BP1_bia</td></tr><tr><td></td><td>D. prostipennis y 5' region (-3857 to -107)</td><td>Pros_end, BP1_pros</td></tr><tr><td>pRedSA BP3.1</td><td>D. biarmipes y 5' region (-5398 to -2628)</td><td>Bia_start, BP1_bia</td></tr><tr><td></td><td>D. prostipennis y 5' region (-3562 to -107)</td><td>Pros_end, BP1_pros</td></tr><tr><td>pRedSA BP3.2</td><td>D. biarmipes y 5' region (-5398 to -2483)</td><td>Bia_start, BP1_bia</td></tr><tr><td></td><td>D. prostipennis y 5' region (-2982 to -107)</td><td>Pros_end, BP1_pros</td></tr></table>
<table><caption>**Table S3. Significance of pairwise comparisons between chimeric constructs.** Probability values were calculated with a multidimensional Kolmogorov-Smirnov two-sample. Nonsignificant p-values (alpha > 0.05) are in bold font.</caption><thead><tr><th></th><th>y5<sup>pros</sup></th><th>BP1</th><th>BP2</th><th>BP3</th><th>BP4</th><th>BP5</th><th>y5<sup>bia</sup></th></tr></thead><tbody><tr><td>y5<sup>pros</sup></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>BP1</td><td>0.027198</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>BP2</td><td><strong>0.054959</strong></td><td>0.010732</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>BP3</td><td>5.70E-07</td><td>3.00E-05</td><td>1.77E-09</td><td></td><td></td><td></td><td></td></tr><tr><td>BP4</td><td>3.40E-08</td><td>2.70E-09</td><td>2.81E-08</td><td>1.83E-07</td><td></td><td></td><td></td></tr><tr><td>BP5</td><td>1.27E-08</td><td>1.50E-09</td><td>1.09E-09</td><td>4.00E-08</td><td>0.00012</td><td></td><td></td></tr><tr><td>y5<sup>bia</sup></td><td>3.12E-07</td><td>7.20E-08</td><td>7.13E-08</td><td>7.33E-06</td><td>4.17E-06</td><td>0.000612</td><td></td></tr><tr><td>θ</td><td>2.31E-09</td><td>6.21E-10</td><td>2.21E-10</td><td>1.70E-07</td><td>1.90E-08</td><td>5.77E-09</td><td>6.63E-06</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>y5<sup>pros</sup></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>y5<sup>bia</sup></td><td>3.24E-07</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>PB1</td><td>5.90E-06</td><td>0.048708</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>PB2</td><td>7.63E-05</td><td>0.004749</td><td><strong>0.111042</strong></td><td></td><td></td><td></td><td></td></tr><tr><td>PB3</td><td>6.65E-05</td><td>0.001254</td><td>0.029324</td><td>0.017538</td><td></td><td></td><td></td></tr><tr><td>PB4</td><td><strong>0.463593</strong></td><td>2.19E-06</td><td>2.09E-05</td><td>0.000156</td><td>0.00018</td><td></td><td></td></tr><tr><td>PB5</td><td>0.013613</td><td>3.19E-06</td><td>2.62E-05</td><td>0.000172</td><td>0.000405</td><td><strong>0.074441</strong></td><td></td></tr><tr><td>θ</td><td>4.07E-06</td><td>0.000193</td><td>0.000363</td><td>0.001307</td><td>0.004243</td><td>1.98E-05</td><td>2.53E-05</td></tr></tbody></table>
Text S1. Construct sequences (Insert)

5' regulatory regions upstream yellow gene

>pRedSA-y 5'~ana

GAACTACCCATCCAACACCGCACCCCACTTAGAACCACGATTAGCAGCAGTTGTTCAAACAGAAATTTACTGGCTG
GCTGGTTCAGCTTCAGTTGATAATTAAATATGTTGTGGCCGGTGTGCCGTGGTCTTTTCTTTTATGGCCAACATTTTT
AATTGGTCAAGACAAAGGCACAGTTTTTATGCATAATTAGAGGCTTGAAATTTTGGATTCAGCACAGTCCTTCAC
ATTGCCGAACTGGCCAATTACGATTAGTAATAAAAATTAGTGAAGAAAGCTAGTGGAAAGTTGAGATACGCTTTTG
GTTTAAAAGTGAACAAGTAGTATGTTCTTTTTAGGGGCAATAGGTATACCCCTTGGGAGTGTCTATAGAACTACTT
CTAAAATTGGTCTAGCTTTTCATCACGATGAGCAATCGAAGCTTAGCCTTGAAAGAGTTCAACAACCAATACCATT
TTCTAGACCCTTCTAATTTTCTAGACCCTTCTAATCGTAATATCACCTATTAAGCCTCCAAAATCCAATTTAATAAT
GCCCCACTGTACAAAAGACATACAGCTTCCTGGAGGAGCTATTTCCCAAAAAACGAAACCCCATTAAACGGACTA
GGAGGAAGCCCGATGTAGTAGCTTGGCCACTGAGATTTAAATAGTATTTAATTGATAACTAATTGCAGCGAGTCGA
GTGCCAAATCTCGACAGTGAACGAAACGGCAGTGACGTTTTCAATGTTGCAACTTTTTAGCCAGTTTATTGGCAGA
CCACATCGACGCTGCTGTCTAACAAAAAAAAAAGAGAAAAAAAAGCAACACTTTTCACCAGGAAATCAATAAAC
ATTGCCCGAGAAAAACACGCAATGCTACCACGCACATCTCAATCAAGTAAATGATCGATTACATTTTCAATTTTCA
TTTAAATTATTTTATCCATTGACGTCTCCAGTCGTGGACCCCCTCAAGCTCAATGCGTCGTGTTAGAAAACCGAGAA
AACTCTCTGTTAAAAATACTTAGCACAATTTTACTTTAGTCACTAATTTTACTAACAAATGTGGGAAATAAAGTGA
CCCACTTGGTAGCGAAGAAATCCAGGCCACCCTTCTAGCCTATAAATAGTGCGACATTTGCTTTCGATTCTTCAGAT
CACTTTCTCCGCTCATTCAGTCTTCAAGTCGGAAACAATATGAAACCTCAATGGCAGTTTCTTTTGTGTTTGATGCT
CGTTCTTGCAGTCCTGGCACCCATTGTGAAAGCAGAGTCCTGGGAGGAGGATACTGCGGCGGAGAATACCTCGGA
AGACAATACAACAGAGGAGAATACCACGAACGAGGATACTACGAAGGAGAATACTACCAGGAAAGATAACACTA
CGAACGGAAGTACCAGGGACGAGAAAAAGGATACCTCGGATAAGGATAGCTCAGAAGAAGGTCCCTTCGACGAC
TACTGGTCCCAGGAAGAGGCTGTCATCAACCCAGGGGCAGTACAAACCCCAGTGGACTACCTAGATGTGGCAGAC
TTTACCCCAGCACCGTCCTCCCTGGTGGGAATTAGGAGGACTCTTTAATCCTTACAAAAAGAGTAATTAATAT
TAAATTTAAGAGGTTTAATATTTTTTTTTTTTAATAGTTTTAAGGCCTGTTTTGTATGCCTAGTACTGGGCATCATATA
ATTTCTAGAATGTAAAGATCAAAGATCCAAGCCAATGCACCAACTCTTACCATTTCCTTAATTTACACATCAAAGA
AAATAAACGATAATATCAAGTCCATAATTATTAGCCACTTTTCTGTTTACCTTTCATAATTGAAACAGAAAAACTTG
GTTGTTTTGACTGCTTGTTTAATTTATTATACGTTTCACCCGGCATACACTGAGCGGAACTGGAGCTGTCAAGCGGT
AAACACGGTTGTCCAACTAATTTACTCTAAATCAGTCCCATCCTCTTTGGCCACTCACCGCTAATGGAAGT
GTTCACCAGGCTGGGATCTGGCGATTATTAATCGATTATAGTCCGATTATCACATTGGGCATCTCTTTAAGAGTCAT
ACGAAATACAGCTTATGCTGTCTTAAGATAACCGAAGTCTTTTCATAAATTTTGAACGCAACCAGCCGATTTATCA
CTCTGCTAAGCGATCTCTAATCCCCCCAAACCCGATCACATTGTAACATTTTTGACTACTGACTTTTCCTCTTGCGT
GACAAGAGCACAGCATTCGTAGGAAAATTATGCCCCAGGCAGTGCCATAGACAAGGCACTGGGAGAAATGTTTTA
TTATTTATTTAATTGGGGGAGTTCCATTTTTTTTTTAATTTATGGCTATAGCTAAGAAGTGGAGGAGTAGAACCGGAT
ATCATATAGTCCAGAAACTGCTACTAGTTTTCTTTTAAAAATATATGAGGAATTATTAAAGAAGAATATGGTATTA
GAGTTCAACCGAGAATCATTAAGGAGAGGATACAAGTATCTCTCTAATCTCCCCCTTATAACACTAAAATAGTAAT
CCCCCCTATAGATTTTCCCAAAGTGTCATCTGTTTAGTGCAATTGGGGACAGTTGTGATGGGTGCATGTGAGCAGGAAA
TCCATATGGCTTGTCTGATTTTGACCAAAACAAATAAATCCAGCTAGTGGAGTGCCGACGCGACGGTCAGGGCCAT
GGACATTGAACTTGAAAACGCAGACAACAAACAAAATCGAACGGAAAATGTTTTGGGGTAAAGTTATAGGGGATA
TTGGTGGAGAGGTTGGCGAGTTGGGCGACTGGTTTCCCATTGGCCTGGCCAAAACAAAAAAGGCCTCCTGAATGGA
AGATGAAAATCAAAAAGAGTTAGCTGCCATTTGCCATAATGAAAAATAAAATAATTAAAAAAAAGGAAAAT
TAAAACAAAAAGTGTAAACACGAGCAGGACATGTCATTAGAGTTGTTTTCATTTTCCGCCCAAGATCCAAGTGGC
TGTTGCTGCTAATGTTGCAAGTTGCATAAGTGGCATAAGTTGGCAACGTTCGGCAATTATGTCAAAGAGTGCGGAT
CCGTTTCGTTTCGTTTCGTTTCGGATCCGTGGCAACTTTTGGCCACTTAGCTAGCCATTTGATAATGTTGTTTTGTAT
CGACGGTGTCGCGGCGGTGGCGTTGAAAACCAGAAAACAAAAACCGGATTCAATTATTGGGAAAAGCGCCCGTTG
AACGTCGCATTTTTAATGCAACCATGCCACATGCATTGGGATGCGTATAAATCATCCGCAAGAGCCTCGGAGAAAC
TAAAAACAAACAAACTATAACAACAAGACACAAGGCGTCCCACAACAAAACCGAAAACAAGTCAATTCGATTTA
AATGATAGGTTCAACGGCTGGCGATTGGATCGCATCATAATTGCCTCCAGTGGCGAGTTATGCAACTTGAAACAT
CAACATCAACATCAACACCAACATCAGCCTGCAACATTAGCCCCACAAGCCCCACACAACTTGCAACGCACAATT
AATTAATAAAACGCACTGGTTATTTTCGAAGTACCTCTCTTTATGGTCCGACCAACTGTGCGTAATAAATTAAGCA
TTAGTCGTATGTAATTATGTAGAGCATATTGCGAATTGTGCGTGTTTGTCGCGCTTTTTCATTTTGATTTTTATTTTG
ATTTATTTTATTAATTATTGGCTGGTTTTCAGTGGGCGGGACTGCAGAATGCGGTCAAGGGTTTCGGTTTTATGGAC
TTAATGGCCTAAATGGAGCTTACAGAATAATATTATTCCAAATACTACTGATTCCTCAGAACAACAAAATGGAATA
GCTTGAATTTCTTAAATATTTCTTGCTTATTCTATAGTAAAATGAATATTATGCCTTTTAATATAAATGTGTTAATAG
AATTTTATTTATTTTCTTTTATTTATTTCTGCAGAAGTTTTTCTGCATTTCCTAAAAAGAGTCTCATACTTTTATTG
CTAAACAACACAGTTTAAAATAAGTAGTGTTTAAAAATAATTTAATTAAATAAACAATTCTCTTTCTAAATAGTC
TTTAAATATTTATAATAATAATATAAAAAAATCGTTAACCCAAATTTTAAAATAATTATATCTTGCTCTCAAAAC
TCCCTTTTAAAAATGACAAATCTCTAACAGCCACATCTTAATTGTCACACATTTTCAGTTTTTAAAGCGATTCTTAAT
AATCCCCAGCCCAATAAAAAATGCTTCTTAATTTGAAATACAATTTTTGCTTTACTTAGTGAGTGGGTCTAGCCAT
TTAAGATTAATGCCAACCATTCTATCAGTGGAGGTCGCCGAAGACATCAAAACTAAATGAAAACTTCAAGACCCCT
TCGGCTAAAAATATACCTCCTTCCCCCTTCTCCGTTTTTTTTTTATTATGCGTGGTTAGTTTTTAAGCCAACTGCATTG
GACCAAGAGTTATGCAAATGCATTTGAATTACTGCAGTTTGCAGCTTGCGGCGATGGCCATTAGAGCATTACCAGA
AAATAACCATAGGCGCCTAGAAGCCAAAGCGACTGCGAGGACCACAAGTGCCGGCAGTTGCGTGAGTGCTTCCTG ATCCACACACTGATGTTTCTCTACTGACTGATGTAATGGTTGGCTTTCGAAAGGGAATCCAGCCAACACGTGCCTC CACATCTTGGCTTTGTAATTAACGCCTGACCCTCGGACTGTGAATCATCGATGACGCCCTAGCGAGCCCCGAAAAC CAAAGCAGTTCAATCGAAAAACTAGCTAGTAATTAGAAATATATTACACAGATATGGTGTTCAGAGTATGCTCTA TAAAACGGAGTAAAAATAAATATTTTAATAGATATTTTTAAAGAACATTATTCACTAGTTTTAGAAAGTTCTGGAT CTGGTTTTGGATCTGGTCTGATCTTGATTTGATTTATATTTTGTATATATTGTATATTGTATTTTTATTTTAGTGAAAT ATAAAAAATTATCTATTATTTTAAATATGGTTTCTGAATATTTTGAATTTGATTAAAATAATCTCCAACCTTTAACT TTTAAGCGAAAAAGCCAGCCCTTCCCTTAATAATTTCTTTGAACAAATTGCAAATTTTAAAACTCATTGCAACTAT TAAATTTATAATAATTTTTTTTTACTGACTAGGCACTATTATTTATAGATTTTCAAAGCCTTATTTTTAACCGTATAC CCTTTCCAAAGAGCTAAAAAAATTGCAAACTCAATCAAAGTGGCAGCGCGAAAGGTTAAGGGGTTCGGTTAAA AGCGGCCAGTGGTTGAGGGTTGGGGGCTACCTGTGTGCTTTAAACGGAATTAAAAAGGCCGCTAAACATGCGTG AAAATCAATCATGGAACACTCAAATCCCCAAGCCCAACCACGCACAATCGCCGCCAAATTATAATGATCGGTGA AAAAATGAAACCACCCGAAAACCACCCGATATCCACCCGAAGTGCTGGTGGCTATGCTATTATTTTTGTGGTGGTT TTCAAACCCGAAGAGGCTAATACCACGCGTTAGCGCCTTCGGTTTAGGTCTCGGTTTTGGTTTCGGTTTCGGTTTTG GTTTCTTTTCGCTTGGAGC

>pRedSA-y 5' bia

CAAGAGCCCAAGGTCGGTCGTTTAGCTTGGCCAAAACCTACCCATCCAGCTGGCACTTCCACCAACGGCACCAAG ACACGAGCGGAAAATAAAAAAGCCACACCACCCCACTTAGAACTCCGTTTAGCAGCAGTTGTTCAAAACAGAAATTG GCTGGCTTCGGCCGGTTCAGCTTCAGTTGATAATTATTATAATATCTATGTTCTTGCCTATCGCTGGGCCCTAATTGG CCCAGACAAAGGCACCGTTTTATGCATAACTGGAGGCTTACAATTTGGCTTTCGACACGCGGTCCTTCACATTGC CAAAAAGAACGAGAACTCAGCAAGCCAATTACACTCGAAAAAGCAGCGGGGATCGTTTCGATGCCTAGCCCTGGG CTAGTTCAATCACTCCCGCCGATAATTGGCCGGCCTCTGCAATGGGAACTTTTCCAAGACGAGATCGATTCTTGGG AAAACACCTCCTCAGTTTCCATTTCTGTTTTTTGGGTCCGGAAGTGGCATCGTGTTCTCCCAGAAGCGCCTCCAAAT GGTGCCACCATTAGCCAGGGGAAGCCGGGCGGCAGTCACTTAGCTGCTGCAATTTAAATACTTTTTAATTGATTA CTAATTGCGGCGAGGCAAGTGCCAAAACAAGACGACGAGGACGACTTGGCTGTGACGTTTTCGATGCAACCCGAC CGGGGACTGCCACTCTTTAGCCAGTTAATTGGCAGCAAAAGCGACAGTGGCAGCGGCAGCAACTGCTTTTCACCA GGAAATCAATACGCTCGTCGAGGCAAAAGTAATCGCAACACGCAACACATCTCAATTTCGGACAGCAAAAAAAA ACCCTCACCAGCTCAATTCCCCGTGCCAAATTAACCAGAGCAAACATAGCCCAGTTTCTTCTCCTGCGGCATGTGA AAAGGCAAACAGTGCTGGCCGGAAAATACCCAGCAAAACACCTGAGTTCTAGTTGCGATTTTCGGAATTGGACTA TAAAAGGCGGCCGTCGGGTAGCTTTCTCACTCACAACCAGTCCAAAAGCATCTCCAACATGAAGTTCTCCAGCA AATCGTCCTGGGTCTGGTGCTCGTCCTGGCCATCATGGGTCGCTGGCCAGCGCCAAGCCCCAGGAGGCCGAGGA ACCGGAGGAGTCGCTGGTCGGGGACTCAGAGTCGGGACAGTCCGTGCCCGAGGACGCCAGCAGGACTACCTCAA CGTGGCGGACTTCACCACTGCCGCTCCTACATGGTGGTGAACTAGAGCCCGGGAATTCTAGAGGATTTTAACAAT CTTTTGTTTTTTTTTGCTAATCTAATGTACTATAATTGCAAAGAATTTATGGTGTCCATATTCAATAAACCTATTTA AAGCTGAATATAATGTAAACCGTATATAAATGTTCTTGTTATGATACATTTTACTAAATTAAAAAGTTAAATAATTA AATATTTAATTTACTCATTGTGGGAGTTCATTAGACTTATTGTTTGTTTTTATTAAATTGTAATTTGTATCAAAAGT TTAAGTTAAAGTCTTAAAAATATATATCAAGTTCATTGCACAAATTAACTAAAAATATGTACCAAAAATGTAGAAA TCAACCTATTTAATCTAAATGTAAATAAATGTAACAAACCAATCATGTCTTAAATTAAATATGTTTTTAAGCCTAAC ACTTATATTTAAAAAATAATTATAATTCAGACTTAAATTTTAAAATCGTCTCACCTTTTTTTTAGTTTATTTGATGCAT GTGTTAATTTTGCTAAAAATCGTATTTTGATGTCTATTCATTTTGCAGCCAGTAATCTAAAAAGTCGACCTATCACT CTCCCCCTCTTATATTCGACCTATAAATACCCACCGCAAATGCCGCAACCAACCTAACCCACAGAGCCAGTTCGG GTTGTTAATGGACAATTATCCTTAGTTCAGAAaGCGCCTGCCTTTATGCGTATTTCCCCGCTTGCCTGCGAATACG CCTAACGAAATTTACTCGAGCCCGTAAACCCAGTTTCGCGTAAGTGCTTCTTTATGAATATTTTCCATTTACTTTAAT TGAAAGCTGCCAATTGTGGTGCCCGAGTGTTGTGACTGCTGGCCAATGAGGCGGTAATACGTTAAGTCGGAGCTGC GGAACGGGATGATGGACCAGTTGAGGCGAAGTACATCAATCTCATTTGCCCGCACTTATCGAACGGTTGCCTTGGG GAGATCGCTGCGATTGCTTATCGATAATCGCCCGATTACCGCGCTGAGCGGTCTTAAGACCCATAAGAAATGCGG CGATGGCGGCTTTAGATAAGTAAGTCGTCGGGGCGCTCATAAATTTCGAGCGCGATCCACGGATTTATGCACTCGC TGGAAAAGCTATTACCATTAGGCTTTTCGCGACCACGGATTTTCCGCTTGCCTGAGACAAGTGGCGCGCGCAGT TGCAGGCAAATTATGTGTGAGGCAATGCCGCGGGCATGTCTACACCGAAATCAAATTACGGCAACCTCTATTCACT TATTTGCTTAGTTTTTTGCGCAGTGAGCGGCCAGCGCCTTGTATTGGCATCTAATTATCCGTTTAAGGACGCAATT TTCTGAGCTAAAACTCGCTTATGGAGAGATCTAAATTTCCCCGCTTTTGGCTTGAATAAATTAATCGAATCCCCGC TGGCTATTAAAAACACACAAAAGGCGCTCTCGTCTGTTTCAATGTAAATTGCAAATTGCTCAATCCGCCTAATTGAT GTGCGCCCATGCAATAGTTTTGTGCCAATCATTTTTAGTACACCCCTAACTGGTGTTTCTACGCATAATATGTGCC ATGGCTTAGGGCCTTTTGGTGGACTTACCAACTGAAGAAGACGATTGTGGGGGTGCGTTTGGCGCAGTGCACGCCT GCGAGCAGGAAATCTCTTTCTCGGCCTGTCTGATATTTGGCCAAGACAAATAAATCCGGCTGGCAGATAGGCAGAG GGGACCCGGCGGTCAGGGCCGTGGACATTGAACTTGAAAACGCAGCCAGCGCCGAAAACATTGTATTCAACGAAC GGCAAGTGCTCGCGGTCGATGGGTGCTCTGGCTAAGGTTACGGCGTTGGGCAACAGGTTTCCCCCGGCCAACAC TGGGAGGAGAAAATAAAAAGGAAAATGTTCAGGCTGCCATAAGTGGGGAAAAAGGAAAACAAAACATGAAACAC GGGCCGGGCAATGTCACTCGGCATTCGCTTGATTTTCCGCCTAACTCGCAGCGGTCCCTGTGTGTAAATAATGTCTA ATGTTGCATGCCGGTTGCATAATCGTGTGGCAATTATGCCAGAGAGATTCGCTTATTTATTTTTTACTTTCTGCCAT GTTCCGCTGCCACCGTATTTCTTTTCGGCACTTAGTGCGCTCCGCTTGATAATGATGTTTTGTTTTTCGCCGGGACA
AACTCGTTTCAATTATTGGGAAAAGCGCGTATAAATCATCGCCGCCAAAGTCTGGCAAAACAGCAAATTGAAAAAC
TGCAATCTGAAAACTGAAAAACTGAAAACTGTAACCCAAACAAACACAGCATCCCACACGACGAGATGAAAATGA
AAATAAATACGGACTGAGCGACTGAAAACAAGTCAATTCGATTCAAATTGCAGGTTCAACGGCTGCCGGCGATCG
CATCATTAAAGTGCGCCTTCGCTGGATACGCGGCTCTTATGCAACGAGCACACACAATTAATTAATAAGCGTCTGGT
TGTTTCGGCCTGGCTTTTGCGGACCTGCCGATCGCAATAAATTAAGGCAGCATTAGTCGCAATTATGTGCCACATA
GTTGGGCTGCTTACTTTTCTGTGGAGGCCAAGGGATCGAGTAAACCGCTTTTCCGC
AGGCCAAGAGTTTTTCGCATTTTGCATAAAATCGGCAACGCATAAGTGGCGAAGCATTGATGAAACTGCGGGAA
AGAAGTAAAAAATTTAAAAAATAAATATAAATTTATGGCAGAACTTAAGAAACTAATTTGAAATACTCCTCCTCT
CCTTAAGAAACTGTCCCTAGGAATATTTGTTTTCCCCAGCATTGCTCAATATTTCCTCCATCTTTTTGCTTATTTCCC
AGACATTTCCTTGGCGAAGTGTAGCTGGTGGGTCTCCAGATTAATGCAAACCACTTCGTCAGCGGAGGTCGTAA
ACGTATCTTTGCCCATTTGGCTCGTTCATTATGCGTGTGGTATAGCTTTATTTTTGCCATTTTCCCTCTTTTTGCAC
CAGCTGCAGTTGGGCCAAGAGAGTTATGCGAATCGGTGCGATTTTCGGGTTTTCGCACTCGCTTGCGGCCATGGCC
ATTAGAGCATTACCCACTTAGGGCGCCCTAAAGTCCAGGTGGTCCCCAGGGACCACAAGAGTATTGCAACTTACG
GCCAGCTGAGTGGAGTGCCGGAACGCACTTCTAATTTCGCGGTTATGTAACCTCGAGCTGAGTGTGCGATACAT
ATGCCAAAATCACCTGCTCATAATTAGCGGAAACCAACTGTTTGGCCCTCGCCGGACTGTGAATCATCAGAGCTGC
CCAATCGAAATCAAAGCCAAGCCAATCGAAGCCAGGTAATTCATATTTAGTGCTGCTTCGCAAaGACCTGTCCCA
GATACTCTGTTTATAGGTATAATTATTAAGTCATATCAGGTTTATTTACATTTATATCGTATAATATTGGTAACTG
CAGCAGCTGCTGTGCTCCAAATTTAGAATCATTTAAAACAAGCCTATTTGCCACAGAAAATGTGTGAAATAATTAA
ACTAAAAGCTTTGGATGAAGTAAAAAAGCCATAAAGCCTAAAATAATATTGAATAATCAAAGAAAATCAGTAG
ATGGTAAAGTACTTCGTACCTACGTTGCATGGTATTCAATAAAGATTCAAAAATACTCTCACCACTGTAAGTGAA
CCCAGTATTTTGTAAATTGCCTAGCACATAAATCAGCTGAATCCTAAACGTATCTGAAGGCCAGGAGTGTCGGAGAA
TTCGGTGTGCCAAAAACCAAAGACCAAAGACCATACCCTTTCAAAACCTTATGAAAAATGGCAAGCCCGGCGAAA
GGTGTTGCCGGTCCAGGGGATTCGGGGCCCGAGATACTCGCACTTAATAAACATGCGTGAAAAATCACAGCG
AAGACAAAAGCCACGCACTAGAAGAAACCAAAGTGTCCGAAGTGGCCGATCCACGGGTGACCATATAGACCATA
AAGTCCGCATGGTGGACCACCACCCGAGCCACCGAAAGCAG

>pRedSA-y 5' car

AACCTACCCATCCAGCTGGTTATTCCACAGAAAAAACATCACCCCACTTAGAACTCCGTTTAACAGCAGTTGTTCA
AACAAAAATTTAGTTGGCTTCGGCCGGTTCAGCTTCAGTTGATAATTATAATATGCTGTTGCTGCCTAATGCTAGAT
TTTTAATTGGCTAAGGCAAAGGCACAGTTTTTATGCATAATTAGAGGCTCACAATTTGGATTTCAGCACTCAGTCCT
TCACATTGCCAAAAAAGAGAATATCAAATAAAAAACTATAACACTATAATTACACGGAAAATCAGCGGGGAGTATA
TGTAATAGTGGATCGATGTTTAACCCTGAGCAAGTTCGACCACTCCGGATGTTATAAGAAATTACATAATTACAT
ACATTCCAATTTATAATATTGGAACTATCCAAACATGATGTTATTCTACTTCTTAGTATGTGCTGTAGAAAACTGTG
TTCCTTAATAAATATTACTCAAAAGTATAAATGTCCTTATCAGAAATATTTCTCAAACTTTAATAAAATAAAAGTTT
GCGAACCTCATTGACTGAATTTCTAATTATTAGGTATAGGCATTCCCAATTATTTAATGTTTAATTGTTTTCAACAG
CAATATACATTATTATATCTAAAAATATTGTTGAAACATTCTGAAGACTTTTAAAAATCTTTTCATACACAAAAAATC
CCCACTCAAGTTTAATTTGAGAAAGTGCCACCGTAGTTATCTGCCCAGAAGAGTGTTGAATTGGCTAATGATACCA
TTAAGCAGGAGGAAGCCGAATAACAGTCGCTTAACTGTTGCGATTTAATAGTTTTTAATTGATAACTAATTGCGG
CGAGGCGAGTGCCAAAAACTAGACAGTGGACGACATGGCGATGGTGACGTTTTCAATGTTGCAACATTGCAGCATT
GCAACTCTTTAGCCAAGTTAATTGGCAGCAAAACGACAGTGACAGTAACAACAAAAAAAAAAAACCGCATTTCAC
CAGGAAATCAAATAAACGTAAGTCCGTAACAAAGAAAAAAAACACACAACACGCACATCTCAATTTCAGTAGCA
GATAAACATGGGGAGATAAAAAACCAACCCTGACCACCTCAATTTCTCGTGCTAAAAAATATAAAAGCAAATATA
GCCTAGTTTTTTGTTTTTTATTATGTGAAAAGGCAAACAATGCCGGCAGGAAAACCCACAGCAAAACACTTGAGTT
CTAGTTTCGATTTCGGGAAATTAGACTATAAAAAGCAGAAGTGAATAACTTTCTCTACTCTCAAACCGAAAGTTAT
TTCAGCATGAAGTTGTTCTATCAAATTATCCTGGGTCTGGTGCTGATCCTCGCAATAATGAGTTCCTTGACCACCG
CTGAGTCCTCGGATGACAAGGATGTCAATCGGGAGTCGGATGAATCTCTAATTGGAGATGCGGAATCGGATGAAA
CTTTGCCCGCCGACGTCCAACAGGATTACCTCAATGTGGGGGACTATGTGCGACCACCTCCTCCATGGTGGTTCTA
GTTTCCGCAATTGTTACTATGTTTGCATTTAATTCAAAATGGATTGTTTTACATATCATATTAAAATTCGATTAATA
AACAAAGTTTAATTAGTAAAGTGTTTGTATGGACTTAGAGAAAGTGTAAATTATCAACAAGATTAGAAAGTATATAT
AATTAAAGTTTTCAGCACTTTAATTTGAATATTTAGACGATCAAAATCAACTATTTCACAATCCTCAAATGAGCATT
TTGATTTGTTTAATGGTCAATTATCCTTCATTCAGGAAGTATTAACTTTTAAGGCCCATATTCCCGTGTGCCTTTTCA
ACACTCTAAATTAAATGTTAGTTAAGCCAGTAAACCTAGATTCAGTAAGTGCTTATTTATGAGGATTGAAAGTCAC
GCATAATGGTTTATACATGTCTGGACTGCCCAACTGGATCAACTGGATATGTTAATCCAAAATATATCCAAACGCA
TTTGCTTACACTTATATTTTCCCGACTGTCACCAATGAAATTGCTTGCCTTGACGAGATCGGGCGTTTTATTAATTGA
TTATCCCCCGATTACCATATTGTGTGGCTTAAAGACCCATAAGAAACGGAACCGCCGGCGATGGCTTAAGATAAAT
AGCTCATAAATTGTGAGTGCACACCGCTGAAAAGTGCACTTCCTAAGCGTTTACACTGCTAAAGCTTTTTCGACCG
CTGATTGCATGAGACAAGTGCACCGCAATTGCAGGCAAATTATGCCTGAGGCAATGTTTCGTGCAAGTTTTCACAG
AAATCGAATTACGGCAACCTCTCGGTTACACTTATCTGCCAGTTTCAGCGCACATACATAGCCTTTACTGGCATC
TATTTATTCCATTTTGAGATGTCATTTTCGGAGCTTAAGTTTACAAAAGGACAGATCTAATTTTCCTCTTCTTTGGTT
TGGATCGATTGGGAGAATTCCCCGCTAAAGCATTAACATTTTTTTTATATTGTCCATTAAATGATGCAAATGAGTTT
TTTGTTTAAACATTTAGTATACAAATAATACAATAATACAATACACATATTGTACAATTCAAATAAATTATTTAGCA
GTGGTCTTTATACAACATTTTTTTGGAATACCCCAAAGTTATTTATGTTCTCAGTTTACAACTTAAGAAAAACTTGA
CTATATTAAATTGAAAGAGAGCCTCAGTGTTTTTAACAACAGATTTGATAATGTGTTTTTTAAAACTACTTGATAGA
TTACAAAATATTACAAGACTCATAGCGATATTTATAATCAGTCAATAATGGATCTGTAAATATTAAGTTATTTAGG
AAACGATTTTAGCGCAGTGCATGTCAAACCGGGACATTTGCGATGGTTCCCTGTGAGCAGGAAATCACTGCGGCCT
GTCCGATTTTGGCCAAGACAAATAAATCCGATGGAAAAGGAGGGGATCCGGCGGTCAGGGCCATGGACATTGAAC
TTGAAAACGCTGGACAACATTGAGCGGAGACCGAACGGAAAATGCTGTGTGGCTAAGGTTAGAGCAGTTAAGCAA
CAGGTTTCCATTTTCCATTTTCCATGGCAGATGAACTGGCAAACTGGCGGGAGAAAAAGT
GCAGGCTGCCATAAGTGGGAAAAAAGGAAAACAAAACATGAAACACTGGCCGGCAATGTCATTCGGCATTGGTT
TTATTTCCGCCCAACTCAAACTTATCCTGTGTGTAATAAACGTCTAATGTTTGCCAGCAAAGTTGCATAAGTGTTG
GCAATTATGCCAAAGAGATCCGATTTTTCTCTATTTTTTTTTTCTATTTTCGCTTCGCTTAACTTTTTTTTTGGCCAC
TTAGCGCGCGCTGCTTGTAATGTTGTTTTGCTTCGTTCGCTGGTCAAGAAACTCGTTTCAATTATTGGGAAAAGA
GCGTATAAATCATCGCTGCAAGCGCTGAAAACTGCGAAAACTTACAAAAAACTGAAAATGTAACCCAAAACAAAG
GCAAAACAAACACCGCATCCCACACGACAAACTGCTGAAAAACGAGTCAATTCGATTTAAATAAGAGGTTCAACG
GCTGCTGCCGATCGCATCATAATTGCCATTTCATTGAACACACGGTTTCGTTATGCAACACACACAATTAATTAAT
AAAAACGCACTGGCATTTTAAGCGTGCCTTTTTATGGTCAAGCCGATCGCAATAAATTCAGGCAGCATTAGCCGC
AAATATGTGAAGCATATTTTCCGTCTGCCGCAGGTTTATTTATTTTTCAGTGGGTGAGCCAGTTGTAAGAATGCGA
CCAAGTAGGCTGGCTAAACGACAACATTCTAAACATTATGCATCGCAAGAGCAGTGAAAAGAATTGCCAAAAATA
AAATGTATAATTTAAAGGATTCTTACCAAAATATTCCTTAAATTATTTGTTCCCAGGGAAAATGCTAATCAATAAT
ACATAAAGGCATTTTTATGATTCTTAAAAAATGTACTTTAGAAATATTCCTTTAACTGTTTTTAACTTTTCTAGAGTT
CTTTAATAATCTGAATAAGTAGCATTAACTTTTTGACATTACTTCAGAGGATCGCCCAAAATATTCTAAACTA
TTGTTTAATAACTCCAAATGAAGTACTGAAGTTTTTACCATCAAATAACATTTTCATTAATTTTGAAGATTATTTGA
AAGGTTTTTCGCACGTGTAGTGTAGATTGTGCTATTGAAGTTTTATGCAAAGCACTTCATCGGCACTTTAGTACTA
GTTTCAGTTTGGACCATGCGTGTGGCTAGTTGATACACATTATTACTTTTTCGTAGCTAGTTTTCTTATTGCTGACCC
GTTGCATTTGGAGCAACGAGTTATTATGCGAACGCCTTCGGTCCGAATTTAAAAGACTTTGCATATTCGCTTGCG
GCGATGGCCATTAGAGCATTACCCACTTAGGGCGCCCCTAAAAAATCCAGGTGGTCCACAGGGACCACAACATTGC
AAACTACAGACTGGTGGTGTCTGGTGGAGTTACCAAACGCACTTCCTCAATTTCGGATTCCTTATGCAACTCCGAA
GTCGGAGATATACATATGTGTATGCTCATTTGCAGGTGATTTTTAACCTGCCCATAATTAGCGAAAACCAAATGTTT
GACCCTCGGTGAATTGTGAATCATCGATACTGCCCAATCAAAGCCAAGCTTAAGCAATTCAATTGAAACCAGCTC
AAGTAATTCGTATGAAAAGCTGTTGGAAATACCTGTTTGAATTATTCGATATTACCATTAAC
TTTTAGTATCTGGCACACTTATAATCTCATAAATAAATATATTTATATCATTTACTTATGTTATAAGTAAGTGCAAT
TCAGTTAACGTAGTAAAAAACCATTTCAATTTAAATAAATAAACACCAAGTTGTTATACCACATTAGACGGCTTTC
AGCTTTTAATGGAACTTAATAAATGTTTAATTTATAACTTATTTAATGCTCTTAGGCCTTAGCAATTATTTGTTTTA
ACCAAACATGTTACGTTTCTTTAGTAAAATGAGTCATTATTCTGTCGTATGTTTCTAGTTTCTAATTTGATTGC
AAATAAATCAATCTTAAATGCCGATGATTGTCAGGAAGTTTAGCGATTCAAGACCCTTTCGAAAGGGTATGAAATT
GGCAAGCCCAGCGAAAGGTGTTGTTGATTCAGCGAATTCAGGGGTCGCCATACTTAAATCTATAAACATGCGTG
AAAATCAATCTTGAAGACAAAAGCCACGCACAAAAATGCTCAAAGTGAGCCGATCCATGGGAAACATGTGGAGT
ACCATTGCCGAACCACCGAAAACCACCGAGCACCACCGAAAAGCTCGAGTAATCCGAAGTTGGTCCTTCGGTTT
CGTTTTCGTTGTCGTTGTCGTTTCCATTGGCCTGTCTTCGTCT

> pRedSA-y 5'te

AACCTACCCATCCAGCTGGTAAATCCAAACAAAAAAAAAAAAAAAAAAAAAAAAAAACAACATAACCCCACTTAGAA
CTTCGTTTAGCAGCAGTTGTTACAAACAAAAATTTAGTAGTTAGCTTCGGCCGGTCAGCTTCAGTTGATAATTATTATA
ATATGTTGTTGCTGCCTATCGCTCAATTTTTAATTGGTCAAGACAAAGGCACAGTTTTTATGCATAATTGAAGGCTT
ACAATTTGGATTCAGCACACAGTCCTTCACATTGCCCAAAAAAAAAAAACTAATAATAACGAATAAAACTATACCT
CTAATTACAATCAAAAAACCGTGGGGGGGTGAAGAAAATAATGGGTCGTTAATCGATGTTTAACCCTGAACGAGT
TCGACTACTTCCGAATATAATAATATAATTATATACAGTCCAATTTCTGTTATGGAATTTCTCACAGTAAGGTGTTA
AAAAATTTAATTTATTGATCATCCAATAGCAACAATATGAAAATGAAAATTATTCGACTTGAGAAAATGCCTCCGT
GGCTATCTTCCGAGAAGAATTTCCAAACGCTAATAATACCATTACCCAGGGGAAACCAAATAACTGTCGCTTTT
CTATTGCGATGTAAATAGTATTTAAGTCATTACTAATAGCGGCAAGGCAAGTGTCAAAACAGTGGACGACATGG
CTGTGACGTTTCAATGTTGCAACAAAGTAAAATTGCAACTATTTAGCCAAGTTAATTGGCTGCAAAAGTGACAGT
GGCAGCAGCAGAAAAAAAAACAGGATTTCACCAGGAAATCAACAAACGTAAGTCCAGCAAAACAAGGAAAAA
AAAACACAGCACGCACATCTCGATTTCAGTAGCAGACAGATTTAAATGGGGAGATAAAAAACCAACCCTGGCCAC
CTCAATTTCTCGTGCCAAAAATTAAAGGCAAATATAGCCCAGTTTTTTTATTATGTGAAAAGACAAACATTTCTGG
CAGGAAAATACGCAGCAAAACACTTGAGCTCTAATTGCGTTTTTTAGATGCTAAGGTATAAAAAGCAGAAGTGAA
TAACTTTCTCCACTCACAATCGAAAAGTAGTTCCAACATGAAGCTGTTCTACCAAATTATCCTGGGTCTGGTGCTC
ATCTTTGCCATAATGAGTTCCGTGACTAACGCCAAATCTCTGGAGGATGATGATGCTACCGATGAGTCGGATGAAT
CCCTAATCGGAGATGCGGAATCGATTGAATCTTCGCCCCAGGACGTGCAACAGGATTATCTCAATGTGGGAGACTA
TGTGCGTCCTCCTCCTCCATGGTGGTTCTAAATTTTAATTAAACAATTTTTTTTTTATTTTAAATCTGTTGTATTCAAT
TACTGTATTACTATTCCATAGGACTACATGTTTTGCTCGATTATAAACATATTCCAACTAGTATAATGTTTGAATT
TAATCAGGACAACAAAAACTCATAAGAAAAAACTTTTAATATAATCAAATTTAATTAATTTTCAGTTGCAAAAAAT
GTAAATTAATGCCCTAAAAATATGTAAAAACTTTTCAGCTTTTTCCTAAAATAACCTGAAATTACCTGTTGCTTAAGA
CTCAAGAAACCACTTATATTTATTTTATGGTCAATTATCCTTAGTTCAGAAAGTATACACTTTTAATGCATATTTATT
CCCGTTTAGCTATAAATATTTAAAGCGAAATTTAAGTTTAACTAATAAACCTAGATTCAGTAAGTGCTTTTCATGAA
AGCAGCAACAACAGCTTTTCACCAGGAAATCAATAAACGATACTCCACCAGCACGCACGCACGTCTCAATATCAG
TAGCTCAAAAGCAGAAAAGCAGAAAAGCAAATCGGGCAAAAAAACGTAAAATATTTGTTAGGAGGAGAGATAAAA
AAGCAACCCTGACCAGCTCAATAGAGCTCGTGCCAAAAGCTATGAGCAAATATAGCCCAGTTATCTTGTTTTGGCA
TTTTTTTTTCTAGACTTGTGAAAAGACAAACAAGGCTGGCCGGAAAATACCCGGCAAAACACCTGAGCCCTAGTTC
CCATTGGTTCCGATTTGACTATATAAAGCAGCCGCAGATCACTTTCTCCATCAAACCACAAAGTCCCCGTCTTAAGT
ATTCCAAACATGAAGCTCTTTCATCTTGCCCTGGCTATCGGTTGCTCCTGGCTAG
TGCCCAGCCCTTGGAGGACAGCGAGGCTGATGAATCCCTCATCGGTGACTCGGAGTCGGCTGACTCTGTGCCGGAT
GACGTCCAGCAGGACTACCTCAATGTGGCCAACTACGTCACCCCATCCCCTCCATGGTGGTGAACTAGAAAGTTC
TCGCCTTTCTTTCTTTGATTTTCTTTGTTTTGTAATAATAAATATTTATCATTCTGCCTTAATCTAAACTTTGGTTTT
AATTAAAGTTAAGTTAAGGCCTTAAAGGGTTCTACTAAGAATTATCATCATAGTTCATAGGTATCAGGAGTACCCC
CCTCTAGGCTTGCCACTTTTAAACAGAATTTCGAAATGAATTCATAAAGAGTCTGATTTATTTAATGGCCACTTTTA
TACCCCTTTTAACGGAATTTATTTAAAATAATAAACCCAGATTAAGTAAGTGGCTGCTCTATGCTTGTTTCCATTT
ACTTTTATTAATATCGAAAGCCACGCTGTGATGGCGCCAATAAGTGTTTTGACTGCTGGCCAACGAGGTTGGACA
CTTTACACGGATTTATGCGGCGAACTGGATGATGAACGGAACCAGTTGCTTGGGAGATGTATATCATTCCCATT
GGCTCATTCGGACTAATGGAAATGTTCGCCTTGACGAGATCGGGCGATTATTAATCGATTATCGCCCGATTACC
GCACTGAGTGGCTTAAAGACCCATAAGAAATGCAACCGGCGATGGCTTAAGATAGCCAAGTCGCCCCGCCGACGA
GTTGCTAATCAATTCGAATGCAGCCCGCTGATTTATGCACTCCgCTAAGCTCTTTTTGAGTCGATCTTTCCGCTTGC
ACGAGACACAAGTCACCGTGCAACGTGCAACGTGCCACAGCAGGCAAATTATGTCTTTGGCAATGTGGCAAGCG
AGCTAAAGCTTACACAGAAATCAAATTACGGAAACTTTTGGTCTTATTTGCTTAGTTTTGCAAACGGCAAGCAGGC
AGAGCCTTtGCCGGCATCTAATTACTCCATTTGAGGACTAAGAATGGGCTAATCTGAGCTAAAAACTCATTTAAGGA
CAGATCTAAATGTTTTCCGCTTTTGGCTTAAATCAATTTACAAGATCCTTGGTGACTAGCCTAGAATTCAGTTGA
CAAAGTGGAATCTCTTATCTCCCAAAGATACTATTTCGGAATGCTAAAAACTTTTCCCGCAGTGCATGTCAGACGGG
GACATCTGCGATGGGTGCCTGCGAGCAGGAAATCTCTGCTGCGGCCTGTCTGACTTTGGCCAAGACAAATAATCC
GGCCGAGAAGTACGCCAAAGAGGGGGTTCGGGGAGGGGCGGTCAGGGCCATGGACATTGAACTTGAAAACTCTG
ACAAACATCGAGCAAGACGAATGGAAAAGCTGTACGCGACTAAGGTTAGAGCGGTTGAGCAACAGGTTTTCCATG
CCATTTCCAAATGGATCGAAGATGAAAAGCCAAGTGGGGAGGGAAAGGTGGAAGCAGGCGGCCTGCCATAAGT
GGAAGAAAAGGAAAACGAAAAACAAAACATGAAACACGGGCCGGGCAATGTCATTCGGTATTTGGTTTTATTTTC
CGCCAACTTCGAGTTATCCTGTGTGTAAATAATGTCTAATGTTGCCTCTCCCTCTGCCTCTGCTGGTTGCATAATC
ACTTGTCAATTATGCCACAAATATCCGTTTTTGTTTTGGCCACTTTGGCTGGCCACTTAGCCATTTGATAATGTTGT
TTGGCTTCGTTGTCTTTAGTTTCGTTTGCTCTCTTGCCGCGGCAGATAACTTGTTTCAATTATTGAGAAAAGCGCGT
ATAAATCATCGCTGCCAGCGTTGAACTGCGAAAACAGCGAAAACTGTGAAAAACTGTGAAAAACTGCAgCTGAAAAC
TGAACCCAAAAACAAACCAAAACATGCATCGCAGCATCCCACACGACAAAAACAGACAGACAAAAACGAGCCAAT
TCGATTTAAATTGTAGGTTCAACGGCTGCCACTGCCACTGCTGGCGATCGCATCATTAAATGCCTTGCCAGTGCCAG
TGGTCTCTGGTCTCTGGTCTCTGGTCTCGTTATGCAACGCACACACAATTAATTAATAAAAGCGTACTGGTTATTTT
AAGTATGGCTTTTTATGGACCTGCCGATCGCAATAAATTCAGCCAGCATTAGCCGTAATTATGTGCAACATATTTTT
CGGTCCGCTTACTGATCTGTGGGTGAGCAGCCGCAGCAGCCAGGCCAGGGCTTAGAATGCGGCCAAGGGGCAGCC
GAATTGCAAATATTTTGCATGAAATTAGAATAGATTTATGCTGTGGCAAAATGGAGAACCACTAAAGAACATTCTA
AGTAGATTCTGAGTAGGAACTCAGAGAAGAACGGAGTAGAATCTCCTTTCTGATATCCTAGAAATCCTTTTAATCC
GAACTACTAACTTTACCTCCTAAGACTTTCCTTACTTCGAGCTTAGTTCGCAGATTAATGCTAACCACTTCTTCAGT
GGAGCTCGTAAAATGTATCTTTAGCTACGAGGTTTCAGCTCGTTCATTATGCGTGTGGCTAGAGTTGGATTACCTTA
TTTCTGGCTGGCCAGGTGCAATCTGCGTGCAGTTGCAGGTTGCAGGTTTCG
CATACGCTTGCGGCGATGGCCATTAGAGCATTACCCATTCATTAGGGCTCCCCCGAAAAGTCCAGGTGGTCCACAG
GGACCGCAATATTACGCCAAATTACGTCCAGTTAGTGCTGGCAGTTATGTAACTCTCTACCACTCTCTCAACTTGTA
TCTAGTTAAGTACCTAAGTTTATGCTAAAAAATCACCTGTTCATAATTAGCGGAAACCAAAAGTTTGACCCTCGCC
AAAGTGTGAATCATCGGAACGGCCAATCGAAATTCATAAGCTAAGGCAATCGTCGAAACGAGCCCAAGTAATTCAG
ATTTATGGAACCGGACAAGAAATACCTGATCCGAATACTCTACAAATGTGATAAATATTATTATATTAACATCGTT
AAGACTTAATGCCCTGCCTATTTGCaTATAAACTGACTAAACTAATGCAGAAGTAAGTGCTCTGGCCAATTCCCAA
GCAATTAATGTAAATTAAGCCACATAATCAGACTTCCATTGAGAGTAAGGAGACATTCCACGGGGACATTAAGCC
CGAAGCCTTAAAAATATTTCCAACAAGAAGTTTACGACGCAGCCCCCAACTCAGCCCAAAAGTGTGCTTGGAAT
GTCCCCCCCCCTTAAGCAGATTTCGTCTTAGGCAGAAAGATACTCCCCCTTTTGATATATGTTCATCGATATTTTA
TAAGCAAATTGCACTCCAGCCATCTTAGCCTTACAGCTCGATGAAGGCCAGAAGGTAGTATAGAGAACTCGGAGT
ACTTGAAAGAGTTAATAAGAAAAAATTGCAAGCCCGGCGAAAGGCAGCTTTTTGGCTGAGATTCGGGGCTCGAAT
TTATTAAACATGCGTGAAAATCAATCATGACGGACAAAAGCCACGCACTGAAATGCCTTAACTTGGCCGATCCATG
GGAACCGCATAGACCAACCGACCACCGAATCGACCGACCACTGAACCACCACCCGAACCGCTGAAACCA

>pRedSA-y 5' fuy

AACCTACCCATCCAGCTGGTTATTCCACAGAAAAAACATCACCCCACTTAGAACTCCGTTTAACAGCAGTTGTTCA
AACAAAAATTTAGTTGGCTTTGGCCGGTTCAGCTTCAGTTGATAATTATAATATGCTGTTGCTGCCTATGCTAGATT
TTTAATTGGCTAAGGCAAAGGCACAGTTTTTATGCATAATTAGAGGCTTACAATTTGGATTCAGCACTCAGTCCTT
CACATTGCCAAAAAAGAGAATATTAAATAAAAAACTATAGCACTAATTACACGGAAAACCAGCGGGGAGTATACGA
AAATAGCGGATCGCTTCTTGGCGTTCCATCGATGTTTAACCCTGAGCAAGTTCGACCACTCCGGATGCTAATAAAA
ATTACATACAGTCCAATTTCTGATATCGGAACTATCCAAACATGATGTTATTCTAATTGCTAATATTTATTTTTATTT
ATAATTAATGTAAATGTCCTTATCGGTAATGTTCCTGAAACTTCTGTGCTTCAATAAAATATAAGTTTACGAACCTC
ATTGATTAAATTCCCAAATTATAGGTAGGATTGATTAGCACACTTTAAATGTATAAATTTTTACAACAGCAGTGT
ACATTATTAAATCTAAAATATTGTGGAAACATTTATGAAGACTTTAAAATCTTTTCATACACAAAAAAGTCCCAC
TCAAATTTATTTTGAGAAAGTGCCACAGTAGTTATCTGCCCAGAAGAGTGTTGAATTGGCTAATGATACCATTAAC
CAGGAGGAAGCCGAATAACTGTCGCTTAACTGTTGCGATTTAAATAGTTTTAATTGATAACTAATTGCGGCGAGG
CGAGTGCCAAAACTAGACAGTGACGGCTGGTGACGTTTTCATGTTGCAACATTCAGCAGTCGCAACT
CTTTAGCCAAGTTAATTGGCAGCAAAACGACAGTGACAGTAACAACAAAAAAACCGCATTTCACCAGGAAATCA
ATAAACATAAGTCCGGCAAAACAAGAAAAACAACACAACACGCACATCTCAATTTCAGTAGCAGATAAACAAG
GGGAGATAAAAAACCAACCCTGACCACCTCAATTTCTCGTGCTACAAAATATAAAAGCAAATATAGCCCAGTTTT
TGTTTTTATTTTGTGAAGAGGCAACAATGCCGGCAGGAAAACCCACAGCAAAACACTTGAGTTCTAGTTCGAT
TTGAAGAAATTGGACTATAAAAGCCGCACTGGATAACTTTCTCCACACTTAAACGAAAGTTATTTCAACATGAA
GCTGTTCCATCAAATTATCCTGGGTCTGGTGCTGATCCTCACAATAATGAGTTCCTTGACCAACGCTGAGTCCTCGG
ATGAAAACGATGTGAATCAGGAGTCGGATGAATCTCTAATTGGAGATGCGGAATCGGATGAAACTCTGCCCGCCG
ACGTCCAACAGGATTACCTCAATGTGGGAGACTATGTGCGACCCCCTCCTCCATGGTGGTTCTAGTTTTTCGCAATT
GTTACTATGCATCTAATTTAAAATGAATTTTTTTACATTATTATTTTAAAATTTGATTAATAAATAAAGTTGAATTA
GTAAAGTGTTTGTATTGAGTTAGAGAAGTATAACTATTTAACGAGATTAGAAAGTATATTAGATACTATTCAGT
TATTTGCCTGCTTAAATTTGAATTTGTAGACTATCAAAATCAACTATTTCACAATCCTCAAAAAAGCATTTTCATTT
ATTTAATAGTCAATTATCCTTAATTCAGGAAGTATTAACTTTTAAGCCCATATTCCGTTTGCCCTTTTAACTCTCTA
AATTAAATGTTAGTTGGGCTAGTAAACCTAGATTCAGTAAGTGCTTCTTTATGAGGATTGAAAGTCACGCATAATG
GCTTATACGTGTTTGGACCGCCCAACTGGATCAACTGGATATGTTAATCCAAAATACATCCATACACATTTGCTTAC
GCCTATATTTCCCGACTGTCACCAATAAAATTGCCTGCCTTGACGAGATCGGGCGTTTATTAATTGATTATCCCCC
GATTACCATATTGTGCGGCTTGAAGAACCATAAGAAACGGAACGTTCGGCGATGGCTTAAGATAAATAGTTCATA
AATTGTGAGTGACACCGCTGAATAATGCACTTCCTAAGCGATCCGTGGTACATTTACACTGCCAAAGCTTTTCGA
CCGCTGATTGCATGAGACAAGTGCACCGCAATTGCAGGCAAATTATGTCTGAGGCAATGTTTCGTGCAAGTTTTCA
CAGAAATCAAATTACGGCAACCTCTGTTCACTTATCCGCCTAGTTTTACGCAGTGAACATACATAGCCTTTACTGGC
ATCTAATTATCCATTTAGAGATCTCATTTTCGGAGCTTAAGTTTACAAAAGGACAGATCTAATTTACCTCTTCTTT
GGCTTTGATAGATTAGGAGAATTCTCCGTTAAAGCATTAACATTTTTTTTAGATTGTCCATTAAATAATGCAAATGA
GTTTTTTGTGCATTCTTTAAGTATACAATACAAATTGTCAATTAATATTAGTTCGATGGTTCCCTGTGAGCAGGAAATCACT
TACAACATTTTTTTGGAACACCCCAAAGGAATATATGTATTTTCATTTACAACTTGAGAAAAACTTGACTATTTTAAA
TTGAAAGAGAGCCTCAGTGTTTTAACACAGATTTGATAATGTGTTCTGTGTTATTTGATTAAATAAACAACTTATT
TGATAGATTACAATGTATTACAAGACTCAAAGCAATAACATTCTTCACTCAATAATGGATCTGTAAGTATTAAGTT
ATTTAGGAAACGATTTTAGCGCAGTGCATGTCAAACCGGGACATTTGCGATGGTTCCCTGTGAGCAGGAAATCACT
GCGGCCTGTCCGATTTTGGCCAAGACAAATAAATCCGATGGAAAGGAGGGGATCCGGCGGTCAGGGCCATGGACA
TTGAACTTGAAAACGCTGGACAACATTGAGCAGAGACCGAACGGAAAATGCTGTGTGGCTAAGGTTAGAGCAGTT
GGGCAACAGGTTTTCCATTTTCCATTTTCCATTTGCCAACGCGAGATGAAAATCCAAACTGGCGACTGGCGGGAGA
AAAGTGCAGGCTGCCATAAGTGGGAAAAAAGGAAAACAAAAACATGAAACACTGGCCGCAATGTCATTCGGCAT
TGGTTTTATGTTCCGCCCAACTCAAAGTTATCCTGTGTGTAAATAGCGTCTAATGTTGCCTGCAAAGTTGCATAAGT
GTTGGCAATTATGCCAAAGAGATCCGATTTTCTCTATTTTTTCTATTTTCGTTTCGCTTAACTTTTTGGCCACTTA
GCGCGGGCTGCTTGTAATGTTGTTTCGCTTCGGACGCTAGTGCAAGAAACTCGTTTCAATTATTGGGAAAAGAGC
GTATAAATCATGCCGCAAGCGTTGAAAAACTGCGAAAACTCAAAAAAACTGAAATTGTAACCCAAAACAAACCAAA
ACAAAGGCAAAACAAACACCGCATCCCAACGACAAGCTGCTGAAAACGAGTCAATTCGATTTAATAAATAGAGGT
TCAACGGCTGCTGGCGATCGCATCATTAAATTGCCATTTCATTGGATACACGGTTTCGTTATGCAACACACACAATTA
ATTAATAAAAACGCACTGGACATTTTAAGCGTGCCCTTTTATGGACTTGCCGATCGCAATAAATTCAGGCAGCATT
AGCCGCAAATAAGCGAAGCATATTTCCGTCTGCCGCATGTTTATGTATTTTTCTGTGGGTGAGCCAAGAGTGAGA
ATGCGGCCAAGTAGGCTGGCTAAAAAACAACATTCTGCACATTATGCATCGCATAGCAGTGAAAATAATTTCCAA
AAATAAAATTTTTACTAAAATATTCCTAAAACTATTTGTTTCTAGGGTAAATGCTAATTAATAATACACAAAGACA
TTTTTTTGATTCTGAAAAGATTTAAGTTCCTTTCGAAATATCCTTCAACTATTGTTACCTTTCTATGGCTCTTTAAT
ATTTTCGAATAAGGAAACTTGCAGAAGATCCCCGAAAAGTATTCTTAAACTATTGTTTAATAACTCCAAGTTAAGC
ACTCCAAATAAAGTACTGAAGTTCTTACCATCAATAACATTTTCATTAATTTTGAAGATTTTGTTAAAGGTTTCGT
CTCACGCCAAGTGTAGATTTTGCGATTGAAGTTTTATGCAAAGTACTTCATCAGCACTTTAGTACTAGTTCAGCTT
GGACCATGCGTGTGGCTACTAGATTCACATTATTATTTTTTCGCAGCTATTTTCTTATTGCTGACCCGGTGCATTTG
GACCAAACGAGTTATTATGCGAACGCCTTCGGTCCGAATTCAGAGTCTTTGCATTTTCGCTTGCGGCGATGGCCAT
TAGAGCATTACCCACTTAGGGCGCCCTCTAAAAATCCAGGTGGTCCACAGGGACCACAACATTGCAAACTACAGAC
GGTGTCCTGGTGAAGTTACCAAACGCACTTCTCAATTCGATCCGTATGTAACTCTGAAGTCGAGATACACATATGT
GCATATCATTTGCTAAAATCACTGCCCATAATTAGCGAAAACCAAATGCTTGACCCTCGGTGAATTGTGAATCATC
GATACTGCCCAATCAAAGCCCAAGCTTAAGCAATTCAATTGAAACCAGCTCAAGAAATTCGAATGAAAAGTTGTA
TAGGAAATACCTGTTTGAATACCCTATATATTCGTACTCAACTTACATTTAAATTTTTAGTATCTGGCATACTTATAT
TCTCATAAATATATATATATGTATATTTACTTATGTTATAGGTAAGTGCAATTCAATTAACGTAATAAAAA
ACCATTTCAATTTAAATAAATAAAGACCAACTTGTTATACTACATTAGACGGCTTTCAGCTTTAATGGAACTCAAT
AAATGTTAATTTATATCTTATTTAATGCTCTTCGGCCTTAACAATTATTTGTTTTAACCGAAAATGTTACGTTTTC
GTTGTTACATTGAGTCATTACTCTCGTATCGTATTATCTATTTATCTTAGTGGCAAATAAATCTATCTTTAATGCCGA
TAAAGGCAGGAAGTTAGCGATTGAAGACCCTTTCGAAAGGGTATGAAATCGGCAAGCCCAGCGAAAGGTGTTGGT
TGATTCAGCGAATTCAGGGGTCGCGATACTTAAATCTTTAAACATGCGTGAAAATCAATCATGGAAGACAAAAG
CCACGCACAAAATGCTCAAAGTGAGCCGATCCATGGGAAACATGTGGAGTACCTCATAGCCGAACCACTGAAAAC
CACCGAGCACCACCGAAAAGCTCGAGTAATCCGAAGTTGGCGCCTTCGGTTTCGTTTTCGTTTCTATTGGCCTG

>pRedSA-y 5 kmr

AACCTACCCATCCAGCTGGTTATTCCACAGAAAAAACATCACCCCACTTAGAACTCCGTTTAACAGCAGTTGTTCA
AACAAAAATTTAGTTGGCTTCGGCCGGTTCAGCTTCAGTTGATAATTATAATATGTTGTTGCTGCCTAATGCTTGAT
TTTTAATTGGTTAAGGCAAAGGCACAGTTTTTATGCATAATTAGAGGCTTACAATTTGGATTTCAGCACTCAGTCCT
TCACATTGCCAAAAAAGAGAATATCAAACAAAAAACAAGAGAGAACGCTATAGTCGGGTGCCCCGACTATCAGATA
CCCGTTACTCAGGTAAAGGGAGTGCGAGGAAGAAGGAGATAGAAACTTTGATCACGCATAACTTTTTAACGAATG
GTCCGATTTGAAAAAATTTCTTCTACATTTCGATAGGTATTGATAAACACAATAAAACTGCATTTTTACTTTTCCGAA
ATATTTAAATTTTTAAAATCGTATATTAGCGATTGTGGCGTTAAAGGGGGCGTGGCACCTTTTGAAATAAACTT
GCGCTGCGTAGGAACTCCTAGAATCTACATGCAAATGCCATCTTCTAGCTTTTATAGTTTCCGAGATCTCAGCGTT
CATACGGACAGACAGACAGACGGACAGACAGACGGACAGACGGACAGACGGACATGGCTAGATCGACTCGGCTA
GTGATCCTGAACAAGAATATATATACTTTATAGGGTCGGAAACGCTTCCTTCTACCTGTTACATACTTTTGCACGAA
TACAATATACCCTTTTACTCTACGAGTAACGGGTATAACTATAACACTAATTACACGGAACACCAGCGGGAGTAT
ACGAAAATAGTGGATCGCTTCTTGGCGTTCCATCGATGTTTAACCCTGAGCAAGTTCGACCACTCCGGATGCTAAT
AGTAATTACATACAGTCCAATTTCTGATATTGGAACTATCCGAACATGATGTTATTCCAATTGTTAGTATGTGCTGC
AGAAAACTGGCTTCCTTAATGAATATCTCTAAAAAATATAAATGTCCTTATCGGTAATGTTCCTAAAAACTCTGTGC
TTTAATAAAACAGAAGTTTGGGAACCTCATTGACTGAATTTCTTAATTATTAGGTAATAGGTATTCCCAAATTATTA
AATGTTTAAATGCTTTAACAGCATTGTACATTATTATATCTGAAATATTGTTGAAACATTTCTGAAGACTTTTAAA
ATCTTTTCATGCACAAAAAAGCCCCACTCAAGTTTAATTTGAGAAAGTGCCACCGTAGTTATCTGCCCAGAAGAGT
GTTGATTTGGCTAATGATACCATTAGCCAGGAGGAAGCCGAATAACTGTCGCTTAACTGTTGCGATTTAAATAGTT
TTTAATTGATAACTAATTGCGGCGAGGCGAGTGCCAAAAACTAGACAGTGGACGACATGGCGATGGTGACGTTTTC
AATGTTGCAACATTGCAACATTGCAACTCTTTAGCCAAGTTAATTGGCAGCAAAAACGACAGTGACAGTAACAAC
AAAAAAACCGCATTCACCAGGAAATCAATAAACGTAAGTCCGACAAAACAAGAAAAAACACACAACACGCAC
ATCTCAATTCAGTAGCAGATAAAAATGGGGAGATAAAAAACACAACCCTGACCACCTCAATTTCTCGTGCTAAAA
AATATAAAAGCAAATATAGCCTTTTTAGTTTTTATTATGTGAAAAGGCAAACAATGCCGGCAGGAAAACAC
ACAGCAAAACACTTGAGTTCTAGTTCGATTTTGGGAAATTAGACTATAAAAAGCAGAAGTGAATAACTTTCTCCA
CTCTTAAACCGAAAGTTATTTCAAACATGAAGCTGTTCCATCCAATCATCCTGGGTCTGGTCCTGATCCTCACAATA
CTGAGTTCCTTGACCAATGCTGAGTCCTCGGATGATAACGATGTCAATCGGGAGTCGGATGACTCTCTAATTGGAG
ATGCGGAATCGGATGAAAACTTTGCCCGCCGACGTCCAACAGGATTACCTCAATGTGGGAGACTATGTGCGACCCC
CTCCTCCATGGTGGTTCTAGTTTAATTTAAAAATGGATTGTTTTACATTATTATTTTTTTGAAATTCGATTAATAAACC
AAGTTGAATTAGTAAAGTGTTGGTATTGACTTAGAGAAGTTTACTATTAACGAGATTAGAAGTATTATATAAAGTG
TTCACTGGAATAAGACCCATAGAAACGGAACCGTCGGCGATGGCCTAAGATAAATAGCTCATAAATGAGAGTGCC
CACCGCTGGATAATGCACTTCCAAGCGATCCGCGGTACATTTTACACTGCTAAGGCTCTTTCGACCGCTGATTGCA
TGAGACAAGTCACCGCAATTCGAGGCAAATTATGTCTGAGGCAATGTTTCGTGCAAGTTTTCACAGAAATCAAAT
TACGGCAACCTCTGTTCACTTATCTGCCTTGTTTTACGCAGCGAACATACATAGCCTTTACCGGCATCTAATTATTC
CATTTAGAGATGTCATTTTCGGAGCTTAAGTTTGCAAAGGACAGATCGAATTTTCCTCTTCTTTGGTTTTCATGAA
TTCGGAGAAGTCCCCGTTTTAGCATTAACATTTGTTTTATATTGTCCATTAAATAATGCAAATGAGTTTTGGTATA
AACATTGAGTGTACAAATAATACATATATTGTACAATTCAAATAAATCATTTAGCAGTGGTCTGTATACAACATTT
TTTGAACACCCCAAAGGAATATATGTCTTTAATTTACAACTTGGGAAAAACTTGACTATATTAAGTGGAAAGAGA
GCGTTTCAACAACAGATTTGATAATAAATAATATGTGATAGGCTCAACATTGTTTTAGGGTGTTATTTGAGACTCA
AAGCCATAACGATGTTTGTATTCAGTCAATAATGGATCTGCAAATACTAAGTTATTTGGAAAACGATTTTAGCGCA
GTGCATGTCAAACCGGGACTTTTGCGATGGTTCCTGTGAGCAGGAAATCACTGCGGCCTGTCCGATTTTGGCCAA
GACAAATAAATCCGATGGAAGAGGAGGGGATCCGGCGGTCAGGGCCATGGACATTGAACTTGAAAACGCTGGAC
AACATTGAGCGGAGACCGAACGGAAAATGCTGTGTGGCTAAGGTTAGAGCAGTTGGGCAACAGGTTTTCCATTTT
CCATTTTCCATTGCCAAGCGAGATGAAAATCCAAGCTGGCAAACTGGCGGGAGAAAAGTGCAGGCTGCCATAAGT
GGGAAAAAAGGAAAAGAAAAACATGAAACACTGGCCGGGCAATGTCATTCGGCATTGGCTTTATTTCCGCCAAC
TCAAAGTTATCCTGTGTGTAAATAGCGTCTAATGTTTGCCAGCAAAGTTGCATAAGTGTTGGCAATTATGCCAAAG
AGATCCGATTTTTCTTTGTTTTTTTCTATTTTCGCTTCGCTTAACTTTTTTTGGCCACTTAGCGAGCGCTGCTTGTTAA
TGTTGTGTTGCTTCGTACGCTGGTGCAAGAAACTCGTTTCAATTATTGGGAAAAGAGCGTATAAATCATCGCTGCA
AGCGCTGAAAACTGCGAAAACTTAAAAAACTGAAAATGTAACCCAAAACAAACCAAAACAAAGGCAAAACAAAC
ACCGCATCCCACACGACAAGCCGCCGAGAAACGAGTCAATTCGATTTAAATAAGAGGTTCAACGGCTGCTGCCGA
TCGCATCATTAATTGCCATTTTCATTGGCTGCACGGTTTCGTTATGCAACACACACAATTAATTAATAAAAAACGCACT
GGTCATGTTAAGCGTGCCCTTTTATGGTCAAGCCGATCGCAATAAATTCAGGCAGCATTAGCCGCGAATATGTGAA
GCACATTTTCCGACTGCCGCATGTTTATTTACTTTTCTGTGGGGAGCCAAAAACTAAGAATGCGGCCAAGTAGGCTG
GCTAAACACAACATTCCTACATGCTTCGAAGAGCAGTGAAAAGAATTGCCAAAAAATAATATACAGAATT
TAAAGGATTCTTACAAAAAATATCCTTAAATTGTTTGTCCTAATGTTGCTAATCAATAATATGTATATATATATAT
ATATAATCCTATCTATAATCTAATCTAATAATATATTTATAATCTGATAAAACACAAAGGCATTTTTTTGATTCTTA
AAAGATTTAAGTTCTTTTTGAAATATTCCTTCAGCTGTTTTTACCTTTTCTAGGGCTCTTTAATATTTTCGAATAAGG
AAACCCCTACTTTTTGACTTCGAGAGGATCCCCCAAAAATATTCTTAAGCTATTGTTTAGTTACTCCAAATTAAGTA
CTGAAGTTCTA ACCATCAAATAACAT TTCATTTA TTTGTTAAATTATTTAAAGGTTTTGTC TCA CGCCAAGTGTA GATTGTGCGATTGAAGTTTTATGCAAAGTACTTCATCAGCACTTTAGTACTAGTTTCAGTTTGGACCATGCTAGTTG GCTGCTTGATTCGCATTAT TTTTTTCGTAGCTATTTTCTTATTGCTGACCCGGTGCATTTGGACCAAACGAGTT ATTATGCGAACGCCTTCGGTCCGAATTTTAGAGTCTTTGCATATTCGCTTGCGGCGATGGCCATTAGAGCATTACCC ACTTAGGGCGCCCTAAAAGTCCAGGTGGTCCACAGGGACCACAACATTGCAAGCTACAGACGGTGTCTGGTGA GTTACCGAACGCACTTCCTCAAT TTCGGATTCCTTATGTAACTCTGAAGTCGGAGATATACATATGTGCATGTTTCAT TTGCTAAAAATCACCTGCCCATAATTAGCGAAAACCAAATGTTTGACCCTCGGTGAATTGTGAATCATCGATACTG CCCAATCAAAGCCCAGGCTTAAGCCATTCAATTGAAACCAGCTCAAGTAATTCGAATGAAAAGCTGTTTAGGAAA TACCTGTTTGAATACCCTATATATTCGTAAATTGAACACGTAAATAATAAAATAAACTTTTAGTATCTGGCATACTT ATATTCTCATAAATATAGATATTTATATTCATTTACTTATGTTATTAGTTAGTGCAATTCAATTACGTAATGAAAA ACCATTTCAATTTAAATAAATAAAGACCAAGTTGTTATACCACAGTACCCCGCTTTCAGCTTTAATGGAACTTAAA AAATGTTTAATTTATAACTTATTTAATGTTCTTCAGTCCTAACAATTATTAGGTTTTACCAAAAAGGTTACGTTTTCT ATATAAAATTTAGTCATTACTCTCGAATCGTATTCATTTATAGTTTAACTGCCAATAAATCAATCTTAAATGCCGAT GAATGCAGGAAGTTTAGCGATCCAACACCCTTTCGAAAGGGTATGAAAATGCAAGCCCAGCGAAAGGTGTTGCT TGATTCAGCGAACTCAGGGGTCGCGATACTTAAATCCATAAACATGCGTGAAAATCAATCATGGAAGACAAAAG CCACGCACAAAGTGCTCAAAGTGAGCCGATCCATGGGAAACATGTGGAGTGCCAAAGCCGAACCACTGAAAACC ACCGAGCACCACCGAAAAGCTCGAGTAATCCGAAGTTGGCGCCTTCGGTTTCGTTTTCGTTTTCGTTTTCGATTGGCC TGGCTTCGTCTTCGGAG

>pRedSA-y 5' *pcol*

AACCTACCCATCCAGCTGGTTATTCCACAGAAAAAACATCACCCCACTTAGAACTCCGTTTAACAGCAGTTGTTCA AACAAAAATTTAGTTGGCTTCGGCCGGTTCAGCTTCAGTTCATAATTATAATATGATGTTGCTGCCTAATGCTAGAT TTTTAATTGGCTAAGGCAAAGGCACAGTTTTTATGCATAATTAGAGGCTCACAATTTGGATTTTCAGCACTCAGTCCT TCACATTGCCAAAAAAGAGAATATTAAATAAAACAAGAGAGAACGCTATAGTCGGGTGCCCCGACTATCAGATA CCCGTTACTCAGGTAAAGGGAGTGCGAGGGAGATGGAGATAGAAACTTTGATCACGCATAACTTTTTAACGAATG GTCCGATTTAAAAAATTTCTTCTACATTTCGATAGGTATTGATAAACACAATAAAACTGCATTTTTACTTTTCCGAA ATATTAAAATTTTTAAAATCGTATATAAGCGATTGTGGGCGTTAAAGGGGCGTGGCACCTTTTTGAAACAAACTT GCGCTGCGTAGGAACTCCTAGAATCTGCATGCAAAATGCCAATCTTCTAGCTTTTATAGTTTCCGAGATCTCA GCGTTCATACGGACGGACAGACGGACAGACGGACAGACGGACAGACGGACAGACGGACAGACGGACATGGCTAT ATCGACTCGGCTAGTGACCCTGATCAAGAATATATATACTTTATAGGGTCGGAAACGCTTCCTTCTAGCTGTTACAT ACTTTGCACGAATACAATATACCCTTTACTCTACGAGTAACGGGTATAACTATAACACTAATTACACGGAAAAC CAGCGGGAGTATACGAAAATAGTGGATCGCTTCTTGGCGTTTCATCGATGTTTAACCCTGAGCAAGTTCGACCAC TCCGGATGTAATTACATACATTCCAATTTCTGATATTGAACTATCAGAACATGATGTTATTCTAATTGTTAATATT TATTTTTATTATTAGAAAATATATGTCCTTATCGGTAATGTTCTATCGGTAATGTTCTAAACTTCTGTGCTTTAATAAAACAGAAG TTTGGGAACCTCATTGATTGAATTCCCAAATTATTAGTTAGGATTGATAAGCACACTTTAAATGTTGTCAACAGCA GTGTACATTATTATATCTAAAATTGTTGAAACATTTCTGAAGGCTTTTAAAATCTTTTTATACACAAAAAAGCCCCA CTCAAGTTTAATTTGAGAAAGTGCCAACGTAGTTATCTGCCCAGAAGAGTGTTGAATTGGCTAATGATACCATTAA GCAGGAGGAAGCCGAATAACTGTCGCTTAACGGTTGCGATTTAAATAGTTTTTAATTGATAACTAATTGCGGCGAG GCGAGTGCCAAAACTAGACAGTGGACGACATGGCGATGGTGGCGTTTCAATGTTGCAACATTGTAGCATTGCAA CTCTTTAGCCAAGTTAATTGGCAGCAAAAACGACAGTGACAGCAACAACAACAACAACAAAAAACCGCATTTCAC CAGGAAATCAATAAACGTAAGTACGGCAAAACAAGAAAAAAAAAACACACACAACACGCACATCTCAATTTCAG TAGCAGATAAAAATGGGGAGATAAAAAACCAACCCTGACCACCTCAATTTCTCGTGCTAAAAAAATATAAAAGCA AATATAGCCTAATTTTTGGTTTTTTATTATGTGAAAAGGCAAACAATGCCGCGGGAAAACACACAGCAAAACACT TGAGTTCTAGTTCGATTTTGGGAAATTAGACTATAAAAAGCAGAAGTGAATAACTTTCTCTACTCTCAAACCGAA AGTTATTCAAACATGAAGCTGTTCCATCAAATTATCCTGGGTCTGGTGCTGATCCTCACAATAATGAGTTCCTTGA TTAATGCTGAGTCCTCGGATGATAACGATGTCAATCGGGAGTCGGATGAATCTCTAATTGGAGATGCGGAATCGGA TGAAACTTTGCCCGCCAAGTCCACAAGGATATCTCAATGTGGGAGACTATGTGCGACCACCTCCTCCATGGTGGTT CTAGTTTTTCGCAATTGTTACTATGTCTGCATTTAATTCAAAATGGATTGTTTTACATTATTATATTTAAATTCGAAT AATAAACAAAGTTGAATTAGTAAAGTGTTTGTATTGACTTAGAGAAGTGAATTATCAACAGGATTAGAAAGTAA ATGTAATTAAAGTTTTCACCTGATACCTTTCAGCTATTTGCCTAACTGAACAACAATTAAATTTGAATTTTTAGGCT ATCAAAATCAACATTTCCACATCGTCAAATAGCATTTTGATTTATTAACGGTCAATTATCCTTAATTCAGGAAGT ATTACTTTTAAGGCCCATATTCCCGTTTGCCTTTTCAACACTCTAAATTAAATGTTAGTTGAGCCAGTAAACCTAG ATTCAGTAAGTGCTTCTTTATGATAATGGTTACATGTTTGGACTGCCCCAACTGGACCAACTGGATATGTTAATCAAA AATACATCCATACACATTTGCTTACACTTATATTTTCCCGACTGTAACCAATGAAATTGCTTGCCTTGACGAGATCG GGCGTTTATTAAATGATACTCCCCCGATTAATAATGGTTTCTACTGCCCCAACTGGATCAACTGGATATGTAAATAC
AAAAAATATATCCAAACACATTTGCTTACACTTATGTATATTTCCCGACTGTCACCAATGAAATTGCTTGGCTTAA CGAGATCGGACGTTGATTAATTGATTATCACCCGATTACCATATTGTGTGGCTTAAAGACCCATAAGAAGCGGAAC CGTCGCGGATGGCTTAAGATAAATGGCTCATAAAGTGTGAGTGCACACCGCTGAATGGTGCACTTCCTAAGTATTT ACACTGCTGAAGCTCTTTCGACCGCTGATTGCATGAGACAAGTGCACCGCAATTGCAGGCAGATTATGTATGGGGC AATGTTTCGTGCAAGTTTTCCCAGAAATCAAATTACGGCAACCTCTGTTCACTAATCTGCAGTCAGTTTTACGCAGT GCACATACATAGCCTTTACTGGCTATTAATGTTTCCATATTTGAGATGTTCAGTTTACAAAAGGA CAGATCTAATTTTCCCCTTCTTTGGTTTGGATAGATTAGGAGAATTCCCCGTTTAAGCATTAAAAGTTTTTTTTTAGAT TGTCCATTAAATAATGCAAATGACTTTTGTGTATACTTTTAGTATACAATAATACACATCTTGTACAATTCAACTA AAATCATTTAGCAGTGGACAACTTTTTTTTGGTACACCCCAAATTAAAATATGTTCTCCGTTTACAACTTAAGAAAA AATTGACTATTTTTAATTGAAAGAGAGCCGCAGTGTTTTAACAACAGATTTGATAATAAATGATATGTGAAAAAG CTCAACATTGTTTTTTATGTGTTATTTGATTAAATAAACAAACTACTTGATGGACTACAAAATATTACAAGACCAA AGCCATAACGATATTTATAATCAGTCAATAATGGATTTGTAAATATTAAGTTATTAAGGAAACGATTTTAGCGCAG TGCATGTCAAAGCGGGACATTTGCGATGGTTCCCTGTGAGCAGGAAATCACTGCAGCCTATTCGATTTTGGCCAAG ACAAATAAAAAAATGGAAGAAATGGAAAAAGGAGGGATCCGGCGGTCAGGGCCTTGGACATTGAACTTGAAA ACGCGGGACAACATTCAGCGGAGTCCGAACGGAAAAATGCTGTGTGGCTAAGGTTAGAGCCGTTGGGCAACAGGTT TTCCATTTACCATTTTCCATTTGCCGATGCGAGATGAAAATCCAAACTGGCAAACTGGCGGGAGAAAAGCGCAGGC TGCCATAAGTGGGAAAAAAGGAAAACATAACATGAAACTCTGGCCGGCAATGTCATTCGGCATTGGTTTTATTTT CCGCCCAACTCAAAGTTATCCTGTGTGTAAGTAACGTTTAATGTTTGCCTGCAAAATTGCATAAGTGTTGGCAATTA TGCCGAAGAGATCCGATTTTTCTTCATATTTTTTTTTCTATATTTTTCTATTTTCGCTTCGCTTAACTTTTTTTTTTTT TGGCGCGCGCTGCTTGTTAATGTAGTTTTGCTTTCGTACGCTGGTGCAAGAAACTCGTTTCAATTATTGGGAAAAGA GCGTATATAAATCATCGGTGCAAGCGCTGAAAAACTGCGAAAAACTTACAAAAAAACTAAAAATGTAATCCAAAAGA AACCAAAACAAAAGGCAAACCAAACACCGCATCCCACACGACAAACTGCTGAAAAACGAGCCAATTCGATTTAA ATAAAAGGTTCAACGGCTGCTGCATCATTAAATTGCCAATTCATTGGATACACGGCTTCGTTATGCAACACACA CAATTAATTAATAAAAACGCACTGAACATTTTAAGCGTGTCTTTTTGTGGTCAAGCCGATCGCAATAAATTCAGGC AGCATTAGCCGCAAATATGTGAAGCATATTTTTCGGTCTGCCACCTGTTTATTAATTTTTCTGTGGGTGAGCCAATT GTAAGAATGCGGCCAAGTGGGCTGGCTAAACAACTACATTCTAAACATTAATCATGAGCAGTGAATAATAATACA ATACTAATCAATAATGCACAAAGACATTTTTTTTTTAATCTTTAAAGATTTATTTTTGAAATATTCCTTCAATTTTGT ATACCTTTTCTAGAGTTCTTTAATATTTAATATTTCAATAAAGAAAGCGATTACTTTTTGACTTACTGAT GATCCCCCAAAAATATTCTTAAACTATTGTTAATAACTCCAAATGAAGTACTGAAGTTTTTACCATTAAATAATAT TTCATAATTTTGTAAGATTATTTGAAGTGTAGACTGTGCGATTGAAGTTTTATGCAAAGTACTTCATCAGCACTTT AGTACTAGTTTCAGTTTGGACCATGCGTTTTGCTAGTTGATACACCATTATTACTTTTTCGTGGCTATTTTTATACCC GTTACTCGTAGAGTAAAAGGGTATATTGTATTCGTGCAAAAGTATGTAACAGCTAGAAGGAAGCGTTTCCGACCCT ATAAAGTATATATATTCTTGATCAGGGCCACTAGCCGAGTCGATATAGCCATGTCCGTCTGTCCGTCTGTCTGTCCG TCTGTCGTCCGTCTGTCTGTCCGATGAACGCTGAGATCTCGGAAACTATAAAAGCTAGAAGAATGGCATTTTGCA TGCAAATCCAGGAGTCCTACCCACGCAAGTTTGTTCAAAAGGGGCCCCGCCCCCTTAACGCCAAATCGCTAAAAAC GATTTAAATTTAAATATTCGGAAAGTAAAAATGCAGTTTTATTGTGTTTATCAATACCTATCGAAATGTAGAA GAAATTTTCAAATCGGACCATTCGTTAAAAAGTTATGCGTGATCAAAGTTTCTATCTCCATCTCCCTCGCACTCCC TTTACCTGAGTAACGGGTATCTGATAGTCGGGGCACCCGACTATAGCGTTCTCTCTTGTCATATTGCTGACCCGTT GCATTTGGAGCAAACGAGTTATTATGCGAACGCCTTCGGTCCGAATTTTTAAAGACTTTGCATATTCGGTTGCGGC GATGGCCATTAGAGCATTACCCACTTAGGGCTCCCTAAAAATCCAGGTGCTCCACAGGGACCACAACATTGCAA ACTGCAGACTGGTGGTGTCTGGTGGAGTTACCAAACGCACTTCCTCAATTCGGATGCCTTATGTAACTCCGAAGT GGGAGATATTCATATGCATATGTTCATTTTGCTAAAAATCACCTGCCCATAATTAGCGAAAAGCAAATGTTTGACCC TCGGTGAATTGTGAATCATCGATACTGCCCAATCAAAGCCCAAGCTTAAGCAATTCAATTGAAACCAGCTCAAGTA ATTCGAATGAAAAGCTGTTTAGGAAATACCTGTTTGAATACCCTATATCTATGTATTCAATTTACATTTTTTGGTAT CTGGCATACTTATATTCTCATAAATATATATATATATATATAGATTCATTTACTTATGTTATAAGTAAGTGAATTCAA TTAACGTTATAAAAAACCATTTCAATTTAATTAAATAAGACCAAGTTGATTTAACACATTAGACGGCTTTCAGCT TTTAATGGAACTTAAAAAATGTTTTAACAATTACTTTGTTTTAACCAACATGTTACGTTTTCTTTAGTAAATTGAG TCATTATTCTCGTATCTAGTTTCCAATTTAGTTGCAAATAAATCAATCTTGAATGCCGATGAAGGCAGGAAGCTTAG CGATTGAAGACCCTTTTGAAAGGGTATGAAATTGGCAAGCCCAGCGAAAGGTGTTGGTTGATTCAGCGAATTCAG GGGTTCGCTAAAAATCGCTTAAATCTATAAACATGCGTGAAAATTCAATCATGGAAGACAAAAGCCACGCACAAA AATGCTCAAAGTGAGCCGATCCATTGGAAACATGTGGAGTACCTCATAGCCGAACCACTGAAAACCACCGAGCAC CACCGAGCACCACCGAAAAGCTC

>pRedSA-y 5' pro

AACCTACCCATCCAGCTGGTAATTCCACAGAAAACACCAAAAAAAAAACTAAATAAACTACACCACCCCACTTA GAACTCCGTTTAGCAGCAGTTGTTCAAACAAAAATTAGTTGGCTTCGGCCGGTTCAGCTTCAGTTGATAATTATTAT AATATTTATTGTTCTTGCTGCTGCTGCTGCCTATCGCTAAATTATTAATTGCTCAAGACAAAGGCACAGTTTTTATG CATAATTAGAGGCTTACAATTTGGGTTTCAGCACACACAATCCTTCACATTGCCAAAAAAAAAACAAAAAAAAAG ATTAAAAAATAATAAAATACGAATTATAACACTAATTACACTCGAAAAGCAGCGGGGATCGTTTCACCACAATC GATCGATATTTAACCCCTGGACGAGTTCAACCACTCCCGCTGATAATTGCCCAAGTTCTGTAATTGGAACTTTTCAAA GATGATGATGTTGTTCCCTTGATCAAGTTCTCAAGATTACCAACATAATCGTTAAATATTAAGAAAATCACAACCTC TTAATGATTATCATCTAATCATAAGCAAGCAATCTATATGTATATATCAAACTTAATTTATAATAATTATAATTTTA
AGAATCAAACCCAAACTACCAATATTAAAATATATACCTATATATTTTTTATATCCCACTCAACTTTAAAATCGA
GGAAGTGCCATCGCTGGTATCTTCCCAGAAAAGTTGCCAAATGGCTAATGATACCATAAGCCAGGAGGAAGCCA
AATAACAGTCGCTTAGCTGTTGCGATTTAAATAGTTTTAATTGATAACTAATTGCGGTGAGGCGAGTGCCAAAAC
AAGACAGTGGACGACATGGCTGTGACGTTTCAATGTTGCAACATGGGGTAGCATTGCAACTCTTTAGCCAGTTAA
TTGGCAGCAAAAGCGACAGTGGCAGCAGCAAATACAGCTTTTCACCAGGAAATCAATAAACGATAGTCAAGCCAA
GAGAAGAAAAACAAGCACACACGCACATCTCAATTTCAGTACAGTGCAAAACAAAACAAATAGAGAGATAA
AGATAAAGAAAAAGAAATAAAAAACCAACCCTGACCAACTCAATTTCTCGTGCCAAAAATAAAAGCAAATATAGCC
CAGTTTTAATATGAAAATACAAACAATTCTAATTTTGGCTGGAAAATACCCAGAAAAATAACACCTGAGTTCTAG
TTCCGATTTGTATAATGTTGGACTATAAAGGCAGCCGTAACTTTCTCACTCACAAGTCCTCACAAGTATTGCAAA
CATGAAGCTGTTCCAACAAATAATCCTGGGTCTGGTGCTCATCTTCGCCGTAATGAGTTCTCTGTCGACTGCTCAGC
CCCTTAAGGATGATGAATCCCTTATTGGGGACTCGGAATCGAATGAAACTATACCCGATGACGTCCAACAGGATTA
TCTCAATGTGCCAACTACGTGACTGATGCTCCTCCATGGTGGTGAACTAGACGTTTCAAAGGATTTAGAAAAT
GTTTATTCTTTTTTTTGTGTGTGTTATTATTTTATTAAATTGATGTATTAAAATTACAATATACTAAACCCATTGAA
ACAAGAATATCATGTTGATAAATGGGGTGAAAATAAAATGAAAATTATTATAAAATTAAATTATAAAATAA
CATTTAAAAAATCCATATTTGTTATTGTTATTATTATGTTTTTTTGCAACAAATATTTTATTTGCAATCACTTCA
ATTTCGGTTTTAATATTTCGAAATCATCTTTTTCATAAACCCCAAAAAACCAGTTTTTTTTTTTTTAACGATCAATT
ATCCTTAGTTCAGAAAGTATTAGCTTTTCATGCCGATTTTTTCCCGCTTACCTATAAATACTTGAACGAAATTTATT
TAAGCCAATAAACCCAGATTTAGTAAGTGCTTCTTTATGAATATTTCCATTTAGTTATTTTAATTGAAAGCTACAA
ATTGTGGTTTCAAATGTTGTGACTGCGGAACCGACGAACCACTACCAGTTAATGCAAATATATCATTCGCATTT
ACTTACACTTACACTTATCTTATTTTCTCGGACTGCCACGCCAACTAATGGAAATGTTTGCCTTGAAtAgATCGGGGC
GATtATTAATCGATTATCGCCCGATTACCACATTGAGTGGCTTAAAGACCCATAAGAAAATGCAACTCGTCAACTCG
GCTGATGGCTTAAGATAAATAAGTCGCCGAGTCGCTCATAAATTTCGAATGCAGCCCGCTGATTTATGCACTCCAA
CTTCAGCTGGATGGAAATACTATTACCATTAAAGCGTTTTTCGACCACGGATTTTCCGCTTGCATGAGACAAGTGCA
CCGCAATTGCAGGCAAATTATGTCTGAGGCAATGTTCGTGCTCGTGTGTTTCGTGCAAGTTTACACAGAAATCAA
TTACACGACAACCTCTACTCAATTCACAATTCACTACTTACTTGCTTAGTTTACTTTTCGCGCAGTGAACAGACAAT
GCCTTTATTGGCATCTTATTTGCGCCATTTAAGGATGCAATTTTCTGAGCTAAAACACATTTAAGGAGAGATCTAA
ATTTCTCTTGTTTTGGCTTGAATAAATTTAACGAATTCCTTGCGACTATTTAATACACATAAGGTGGGGGCTCTC
GCATATCTTGTGTTTTAATTTAATATGGTTAAGACATTTGTAATTAGCCAAAAACTCAACTAATAAGGAGCG
ATCTAAATTTCTCTTTTTTTGGCTTGAATAAATTAAGGACATTCCAAGTTGAGTATTTAAATTACACAAAAGGAGCT
GCTTTGAAATCTTGTCTTTTTCTTTGTCTAGTTAAATAGAATATTGGTAAGTAATGTTGTAATGTTATGTGGTATTA
ATTTTGACATGATACGCGGTTATCTCAGTTCGATATGCTCGAAATGTAAATAACAGCCCAAGTTCTAATTTCGAATGT
GTCTTTCTCACTCCCACTCGCGTAATTTAAGTCGCCACATTGCTTTTTCCTCTCTTTTTCGAAGACAGAGAATCTCCG
AGAGAGAGATTTCGGTAAAAACGCAATACCAGAAATTTATCATGCGCATATCGATTTGACCGCTTCTTTTTTTGTGT
GTAAGAAAGCTTATTATACATTATTCATAATTTTATTTTTATTTTATGGATTTAATAAAAATAGTTACGAGCATAA
AAACTTTTATTTTGGTCCTCAAATGTTCCTCCACTTTTTTTGTAGTACGAATATTTTCGTAAAAATGTATACAGAGTT
TATAGAGTTTAATATAAAATAATTCGCAATTAAGAGCACTAATTTGTAGTGCATTTCACCGCAGTGCATGTCAAAC
GTGGACATTTGCAATGGGTGCCTGTGTGCCTGTGAGCAGGAAATCTCCGCGGCTTGTCTGATTTTGGCCAAGACAA
ATAAATCCGGCTGATAAATACAAGAAAAAGAAAAAAAAGGAGGGGATCCGGCGGTCAGGGCCATGGACATTGAA
CTTGAAAATGCTGAAAACGCTGGTAAAACATCCAACGAAACGAACGGCAAATGCTGTGTGTGTGTGTCTTTGGTTT
GGCTAAGGTTAGAGCAGTTGAGCAACAGGTTTTCCATTTGCCATTGTGCCAATGGAAGATGGAAATCCAAACTGAA
AAAAAGAAAAATGTTCAGGCTAGGGAAGAAAAGGAAACAAAACACGAAACACGGGCCGGGCAATGT
CATTCGGCATTTGGTTTTATTTTCCGCCCAAGTTGAAGTGATCCTGTGTGTAAATAATGTCTAATGTTGCCTGCCGG
TTGCATAATCGTGTGGCAATTATGCCAAGAGATCCGTTTATTTTCTTCTTTTTTCACATTTCGTTTTTTGGCCAC
TTAGCGCGCTTGCCGCTTGCCACTTGCCACTTGATAATGTTGTTTTGTTTCTCGTGGAGCAAAAAAAAACCCCAAAC
TCGTTTCAATTATTGGGAAAACGCGTATAAATCATCGCTGCTAGCGCTGAAATCTTTGAAAACTGCGAAACTGA
AAACTGTAACCCAAAACAAACCAAAACCGAAACACAAACACCGCCGCATCCATCCCACACGACAAAAAATCAACG
AAAAAAACTGAAAAACGAGTCAATTCGATTTAAATTATAGGTTCAACGGCTGCTGGCGATCGCATCATAATTGCG
CTTTTCAGTGGATACACGGGTGGCTTCGTTATGCAACATTTATACTACACACACAATTAATTAATAAAAACGTACT
GGTTATTTTAAGTGTGGCTTTTTATGGAGCTCCCGATCGCAATAAATTTAAGCAGCATTAGCCGTAAATTATGTGCAA
CATATTTTCCGTTGCCGCGTGTTTTTCTGTTTCTGTTTACTTTTCCGTGGGTGAGTCAAGATCTAGAATGCGGCCAA
GGGATCAAGTTGAACCACTTTTTCGCCACCATAATATTTTTACACATTTTCGATAAAATTAGCATCGCATAAATTG
CGAAAACAAATGCTAAAAAATTACAAAAAATTAACAAAAATTGCGAAAAAAAATGTCAAATATATATATATATTTT
TTAACATTTATTTTGAGTTCTAAAAAATAGCTTTAATAATATTTGACAAAATATTTTCCTTTAATATTTTTTTAGAA
CATTTATTTTGAGATCTAAAAAATAGTTGTAATAATTTTCGACTAAATATTTGCCCTTAATATTTTTTTGAGCCC
AACTTTTCCTTACTCAACGTGTAGATTGTGTGATTCTAGATTAATGCAAACCACTTCATCAGCGGAGGTCGTAAA
CGTATCTTTACCTATTTGGCTTGTCATTATGCGTGTGGTATTACTTTATTTTTTTTTTTGCAGACCAGGTGCAGTT
GGGTTAAAATAGTTACATATGCGAACGCCTTCGGTGGCAATTTTTTTTCTTGGATTTTCACATTCACTTGCGGCGAT
GGCCATTAGGCATTACCCACTTAGGGCTCCCTAAAAATCCAGGTGCCACACAGGGACCACAAAAAATATTGCAA
ATTACAGGCACTTGAGTGCTTCCTTAACTCTTTGAACACTTTACTTATGCAACTCTCAAATTTGTATGTACGAAATGA
AATGTATGCTAAAAATCACCTGCCCATAATTACGCGGAAACCAACTTTTTGACCCTCGGTGAATTGTGAATCATCG
GAACTGCCCAACTGCCCAATCGAAATCAAAGCTAAACCAATCGAAACCAGCCCAAGTAATTCAAATTTAATGCTG
TTCAAGAAATACCTGCTTTGTATACTCTATCTATACGATTTACTATAATGATAAATTATACTAATATCTGGCTTATTT
GCATATATGTCATAAAATAGAAATAAGTGCACTGGTCATATAAATTGAACATATTTATCAACGGGCTTTCAAAAAA
TAATGAGAAATAATTAAATCTGACTTTCAAAAATTACAAATTAAATTACTGTTTTTTTTTTTAATAACTTTGAAAGT
TGTTTATAGATAAAATATTTTTGAAGATGTCACACTGATATTAAGCTTTAAAGCTTTAAAATATTTTGCAACAAAG
AATTTACAAGTTTTTATTAAACGGAGCCGTTCCGTTTTTGGTGCGAAAGCCGAAAATTGCATTTTATGCACAAACC
TGCCAGCCTAAAAGTGTGCTCAAAAATAGTATGAATACTAAATGAATGAATAAACCTGGTAAAAATAATGTCTA
ACTTGAGTTCCATTATATTTATTAAATATACAGTACAGCAATATACATAACTTTTAGTCTTTAAGAAATCAATGTTT
GTAATGTCATCCAGCTTTAATGTATTTTGCAATAGAACAATGTAGTTAAGAAATTTATTTATGTTCATGAATCTGAC
AAATTGTGACTAGCGCTTTAATTTATAAGTATTTTTGTACTTGAGCGTTAGGAAGAAATAAAACCAAAATTAAA
TTAAAAATATACAGCAACTTTATATTTTGAATTAATTTACTCATAAATCAGCAAAATCTCAAATTCAGCTGAAGG
CCAGGAATTTCAAAAGAATTCAGCGTGCCAAAAACCAAAAAACCCTTCAAAAGTGTATGAAAAATTGGCAATCCC
AGCGAAAGGTGACTCGGCTGACTCGGTGAATTTTGAGGGTTCGAGATACTCGTATTTATTAAAACATGCGTGAAAA
TCAATCACTGAATACAAAAGCCACGCACTAAAAAATAAATGCCCGAAGTTTAGACCACCACCGGCCGAACCACTG
aAACCA

>pRedSA-y 5'rho

AACCTACCCATCCAGCTGGTTATTCCACAGAAAAAACATCACCCCACTTAGAACTCCGTTAACAGCAGTTGTTCA
AACAAAAATTTAGTTGGCTTCGGCCGGTCAGCTTCAGTTGATAATTATAATATGCTGTTGCTGCCTAATGCTAGAT
TTTTAATTGGCTAAGGCAAAGGCACAGTTTTTATGCATAATTAGAGGCTCACAATTTGGATTCAGCACTCAGTCCT
TCACATTGCCAAAAAAAGAGAATATCAAATAAAAAACTATAACACTAATTAAACGGAAAATCAGCGGGGAGTATAT
GTAAATAGTGGATCGATGTTTAACCCTGAGCAAGTTCGACCACTCCGGATGTTATTAGTAATTACATAATTACATA
CATTCCAATTTCTAATATTGGAACTATCCAAACATGATGTTATTCTACTTGTTAGTATGTGCTGCAGAAAAACTGTGT
TCCTTAATAAATATCATTAAAAAATAGAAAATGTCCTTATCAGTAATGTTCCTGAAACTTTAATAAAATAAAAGTT
TGCGAACCTCATGACTGAGTTTCTTAATTATTAGGAAATAGGCATTCCCAAATTATTTAATGTTTAATTGTTTTCA
ACAGCAATATACATTATTATATCTCAAATATACACAAAAAAGTCCCAGTCAAGTTTTTATTTGAGAAAGTGCCAGC
GTAGTTATCTGCCCAGAAGAGTGTTGAATTGGCTAATGATACCATAAGCAGGAGGAAGCCGAATAACTGTCGCTT
AACTGTTGCGATTTAATAGTTTTAATTGATAACTAATTGCGGCGAGGCGAGTGCCAAAAACTAGACAGTGGACGA
CATGGCGATGGTGACGTTTTCAATGTTGCAACATTGCAGCATTGCAACTCTTTAGCCAAGTTAATTGGCAGCAAAA
ACGACAGTGACGAACAAACAAAAAATCACCGATTCACCAGCGTGCCAAAAACAA
GAAAAAAAACACACACAACACGCACATCTCAATTCAGTAGCAGATAAACATGGGGAGATAAAAAACCAACCCT
GACCACCTCAATTTCTCGTGCTAAAAAATATAAAAGCAAATATAGCCTAGTTTTTTGTTTTTTTTTATGTGAAAAG
GCAAACAATGCCGGCAGGAAAACACACAGCAAAACACTTGGGTTCTAGTTCGATTTTGGGAAATTAGACTATAA
AAAGCAGAAGTGAATACTTTCTCTACTCTTAAACCGAAAGTTATTCAAGCATGAAGCTGTTCCATCAAATTATC
CTGGGTCTGGTGCTGATCCTCACAATAATGAGTTCCTTCATTAATGCTGAGTCTTCGGATGATAAGGATGTCAATCG
GGAGTCGGATGAATCTCTAATTGGAAATGCGGAATCGGATGAAACTTTGCCCCGCCGACGTTCACAGGATTATCTC
AATGTGGGAGACTATGTGCGACCACCTCCTCCATGGTGGTTCTAGTTTTCCGCAATTGTTACTATGTTTGCATTTAA
TTTAAAATGGATTGTTTTACATTATCATATTAAAAATTCGATTAATAAACAAAGTTTAATTAGTAAAGTGTTTGTATT
GAGTTAGGGAAGTATAACTATTTAATGAGATTAGAAAGTATATATAATTAAAGTTTCCACCTGATACTTTTCAGCT
TTTTGATTAGCTGAACAAACACTTAAATTTGAATTTTTAGGCTATCAAATTAGCTATTTCCACAATCCTCAAATAAGC
ATTTTGATTTATTTAATGGTCAATTATCCTTAATTCAGGAAGTATTTACTTTTAAGGCCCATATTCCCGTTTGCCCTTT
TCAACACTCTAAATCAAATGTTAGTTAAGCCAGTAAACCTAGATTCAGTAAGTGCTTCTTTATGAGGATTGAAAGT
CACGCATAATGTTTTACATTATGTTGGACTGCCCAACTGGATCAAGTCAAAATATGCCAATATATCCAAAC
TCATTTGCTTACACTTATATTTTCCCGACTGTCACCAATGAAATTGCTTGCCTTGACGAGATCGGGCGTTTATTAAT
TGATTATCCCCCGATTACCATATTGTGTGGCTTAAAGACCCATAAGAAACGGAACCGCCGGCGATGGCTTAAGATA
AATAGCTCATAAATTGTGAGTGCACACCGCTGAATAGTGCACTTCCTAAGCATTTACACTGCTAAAGCTTTTTCGA
CCGCTGATTGCACGAGACAAGTGCACCGCAATTCAGGCAAATTATGCCTGAGGCAATGTTTCGTGCAAAGTTTCA
CAGAAATCAAATTACGGCAACCTCTGTTCATTTATCCGCCAGTTTAACGCAGTGCACATACATAGCCTTTACTGG
CATCTAATTATTCCATTTTGAGATGTCATTTTCGGAGCTTTAGTTTACAAAAGGACAGATCTAATTTTCCTCCTTTGG
ATAGATTAGGAGAATTCCCCGTTGAAGCATTAACATTTTTTATATTGTCCATTAAATAATGCAAATGAGTTTTTTG
TTTAAACATTTAGTATACAAATAATACACATATTGTACATTTCAAATAAATTATTTAGCAGTGGTCTTTATACAACA
TTTTTTTGAATAATCTAAAGTAATATATGTTCTCAGTTTACAACTTAAGAAAAACTTGACTATTTTTAATTGAAAG
AGAGCCTCAGTGTTTTTAACAACAGATTTGATAATAAATAATATGTGAAAAAGTTCAACATTGTTTTTTGTGTGTTA
TTTGATTAAATAAACAAACTACTTCATAGATTACAAAATATTACTAGACTCAAAGCCATAGCGATATTTATAATCA
GTCAATAATGGATCTGTAAATATTAAGTTATTTAGGAAACGATTTTAGCGCAGTGCATGTCAAACCGGGACATTTG
CTATGGTTCCTGTGAGCAGGAAATCACTGCGGCCTGTCCGATTTTGGCCAAGACAAAATAAATCCGATGGAAAA
GGAGGGGATCCGGCGGTCAGGGCCATGGACATTGAACTTGAAAACGCTGGACAGCATTGAGCGGAGACCGAACG
GAAAATGCTGTGTGGCTAAGGTTAGAGCAGTTAAGCAACAGGTTTTCCATTTACCATTTTCCATTTGCCGATGCGA
GATGAAAATCCAAACTGGCAAACTGGCGGGAGAAAAGTGCAGGCTGCCATAAGTGGGAAAAAAGGAAAACAAAA
CATGAAACACTGGCCGGCAATGTCATTCGGCATTGGGTTTTATTTCGCCCAACTCAAACTTATCCTGTGTGTAAA
TAACGTCTAATGTTTGCCAGCAAAGTTGCATAAGTGTGGCAATTATGCCAAAGAGATCCGATTTTTCTTCATTTTT
ATTTTTTCTATTTTCGTTTCGCTTAACTTTTTTTTTTTGGCCACTTAGCGCGCGCTGCTTGTTAATGTTGTTTTGCTTC
GTACGCTGGTGCAAGAAACTCGTTTCAATTATTGGGAAAAGAGCGTATAAATCATCGCTGCAGCGTTGAAAACTGC
GAAAACTTACAAAAACTGAAAATGTAACCCAAAACAAACCAAAACAAAGGCAAAACAAACACCGCATCCCACAC
GACAAACTGCTGAGAAAAACGAGTCAATTCGATTTAAATAAGAGGTTCAACGGCTGCTGCCGATCGCATCATTAACTCCATTTCATTGGATACACGGTTTCGTTATGCAACACACACAATTAATTAATAAAAAACGCACTGGCATATTTTAAGCGTGCCTTTTTATGGTCAAGCCGATCGCAATAAATTCAGGCAGCATTAGCCGCAAATATGTGAAGCATATTTTTCCGTTCTGCCGCATGTTTATTTATTTTCTGTGGGTGAGCCAATTGTAAGAATGCGGCCAAGTAGCCTGGCTAAACAACAACATTCTACACATTATGCATCGCAAGAGCAGTGAAAAGAATTGCCAAAAATAAAATGTAGGATTTAGAGGATTCTTACTAAAAATATTCTTAAATTACTTATTCCTTACAGCTGTTGTTACCTTTTTTATTGCTCTTTAATATTTTCGCATATGGAAAGCCTAACTTTTTGACATTACTTCGAGATGATCCCCCAAAATATTCTTAAACTATTGTTTAATAACTCCAAATAAAGTACTGAAGTTTTTACCATCAAATAACATTTTCATTAATTTTTTAAGATTATTTGAAAGGTTTTTCGCACGCCAAGTGTAGATTGTGCGATTGAAGTTTTATGCAAAGTACTTCATCAGCACTTTAGTACTAGTTTCAGTTTGGACCATGGTGTGGCTAGTTGATTCACATTATTACTTTTTCGTAGCTATTTTCTTATTTGCTGACCCGGTGCATTTGGAGCAAACGAGTTATTATGCGAACGCCTTCGGTCCGAATTTTAAAGACTTTGCATATTCGCTTGCGGCGATGGCCATTAGAGCA TTACCCACTTAGGGCGCCCCTAAAAATCCAGGTGGTCCACAGGGACCACAACATTGCAAACTACAGACTGGTGGTGTCTGGTGGATTTACCAAACGCACTTCCTCAATTCGGATTCCTTATGTAACTCCGAAGTCGGAGATATACATATGTATATGCTCATTTGCTAAAAATCACCTGCCCATAATTAGCGAAAACCAAATGTTTGACCCTCGGTGAATTGTGAATCATCGATACTGCCCAATCAAAGCCCAAGCTTAAGCAATTCAATTGAAACCAGCTCAAGTAATTCGTATGAAAAGCTGTTTAGGAAATACCTGTTTGAATACCCTATATATTCGTATTCAATTTACATTAAACTTTTAGTATCTGGCATACTTATAATCTCATAAATATATATTTACTTATGTTATAAGTAAGTGCAATTCAATTAACGTTATAGAAAACCATTTCAATTTAAATAAATAAAGACCAAGTTGTTATACCACATTAGACGGCTTTCAGTTTTAATGGAACTTATTAAATTTTTAATTTATAACTTATTTAATGCTCTTAGGCCTTAACAATTATTTTGTTTTAACCAAAAATGCTACGTTTTCTTTAGTAAATTTAGTCATTATCTTATGTTTCTAGTTCTAATTTAGTTGCAAATAAATCAATCTTAAATGCCGATTAATGCAGAAAGTTTAGCGATTCCCTTTCAAAAGGGTATGAAAATGGCAAGCCCAGCGAAAGGTGTTGGTTGATTCAGCGAATTCAGGGTTCGCTATCTTAAATCATCGGTGAAAATCAATCATGGAAGACAAAAAGCCACGCACAAAAATGCTCAAAGTGAGCCGATCCATGGGAAACATGTGGAGTACCACATAGCCGAACCACTGAAAACCACCGAGCACCACCGAAAAGCTCGAGTAATCCGAAGTTGGTCCTTCGTTTTCGTTGTCGTTGTCGTTTCCATTGGCCT

>pRedSA-y 5' *suz*

AACCTACCCATCCAGCTGGTAATTCCATCAAAAGCACCAAAAAAATAAATAAAAAACTACACCACCCCACTTAGAACCTCCGTTTAGCAGCAGTTGTTCAAACAAAAAATTTGTTGGCTTCGGCCGGTTCAGCTTCAGTTGATAATTATAATAATATTTATGTAGTTGCCTATCGCTAAGTTTTAATTGGTCAAGACAAAGGCACAGTTTTTATGCATAACTAGAGGCTTA CAATTTGGGTTTCGGCACACAGTCCTTCACATTGCCCAAAAAAAAAAAGAATGAGAACTTAATAAGCTAATTACACTCGAAAAAGCAGCGGGGATCGTTTCACCGCAATCAATCGATGTTTAACCTGGACAAGTTCATACTCCCGCTGATAATTGCCCAACTTTTATGATTGGAACTTTTCATAGATGATGCATCTTTTCCGTTTCAGTTCTTAGGTGTAGGAAAAT AATTATGAAATGTAATGATTAGATGGTGTAAACCCCTATTTCCATTTCCAATTTTATTTGTTTTTAGTGTCCGGAA GTGTCATCGTATCTTCCCAGAAGCGCTTCCAAATGGCCAGTGATACCATTACCCAGGAGGAAGCCAGGTAACAGTC ACTTAGCTGTTGCAATTTAAATACTTTTTAATTGATTACTAATTGCGGCGAGGCAAGTGCCAAAAACAAGACGACATGGCTGTGACGTTTTCAATGCAACCCGGGCTAGGATTGCAACTCTTTAGCAAGTTAATTGGCAGCAAAAGCGACAGTGGCAGCAGCAGCAGCTTTTCACCAGGAAATCAATAAACGTTTCGTCTAGCAGCAAAAAAATAATCGTAGCACGCACATCTCAATTCAGTAGCAACTAAAAAATGTGGAGATACAAAAAACCAACCCTGACCAGCTCAATTTCTCGTGCCAAAGTATAAAAGCAAACATAGCCCACTTTTTTCTCCTTGGGCATGTGAAAAGACAAACAATGCTGGCCGGAAATACGCAGCAAAACACCTGAGTTCTAGTTCGATTTTTATAGATTGGACTATAAAAGCCAGCAGTTGATAACTTTCRTCACCTCACAACAAGTCCAAAAGTATTTCAAACATGAAGCTGTTCCAACAAATTATCCTGGGACTGGTTCTCATCTTCGCCTTCATGGGCTCCCTGGCTAGTGCTAAGCCCCAGGAGGCCAAAGATTTGGATGAGTCCTTAGTCGAGAATTCGGAATTGGGCGAATCTGTGCCCGAAGGCGCCCAGCAGGACTATATCAACGTGGCCGACTACACCACTGCTTCTCCTCCATGGTGGTGAACTAGAAAAATTCTAAATGATTTCTACATTGTGTTGTTTTAACTTTTTTTTATTAATTTATTGTTTAAAAATTAAATAGAATTTATTGTGTTCTTTAATCAATAAACCCATGTCATCCAGAATATCATATTTTTTAATTGTACGTTTAAATATACTAAATGGTCTAACTTAATTTGAGGAACTTCATTAAACATATATCATACTTTTATTAAATTTAAATTTATATGTCAAGTTTATTTTCCACCCAGTAAATCTATAAAATATACCTATAATTTTCTATCCGTAAAATTTCGACCTATAAATACCCACCGCAAATTTCGAAACCAACTTATTCATAACCCACAAAGCCAGTTCATTTGTTTAATGCTCAATTATCCTTAGTTCAGAAGGTATTTGCTTTTTATGCATATTTTCCCGCTTACCTATAAATACGCCTAACGAAATTTATATAACCTATAAACCCAGTTTCAGTAAGTGCTTCTTTATGAATATTTTCCATCTAGTTATTTTAATTGAAAGCTACAAATTTGGTCCATAAATGTTTTGACTGCTGGCAAATGTGGTGGTTTTACTTTTGACAAATCAATGCAGCTGAACGGGATGATGAACAGTGAACCAGTTAATGCGAATAATATATCATATATCAATCTCATTTACTTACTTATAGCTTTCTCGGACCGCCACTAATGGAAATGTTCGCCTTGAGGAGATCGGGCGATTATTAATCGATAATTGCCGATTACCACGCTGAGTAACTTAAAGACCCATAAGAAATGCAACCGATGGTGGCTTAAGATAAGTAAGTTGTCGAGTTGCTCATAAATTTCGAATGCAGTCCGCAGATTTATGCAGACCACGGAAAAGCTATTACTATTAAGCTTTTCTCGACCACGGATTTTCCGCTTGCATGAGACAAGTGCACCGCAGCAATTGCAGGCAAATTATGTCTGAGGCAATGTTTTGGGGCATGTCTACACCGAAATCAAAATTACGGCAACCTCTATTCGCTTAGTTTTTTCGCGCAGTGAAACGCAGCAGCGCCTTTTATTGGCATTCTAATTATCCGTTTAAGGATGCAATTTTCTGAGCTAAAACACACTTATGGAGAGATCTAAATTTCTCTGCATTTGGCTTGAATAAATTAATCGAATTCCCCGCTGACTATTAAAATAGACAAAAAGGCGATCTCTTGTATTTTAATGTTAATTACAAATTGCTTAATCCATTTAATTGATTTCTAACCATATATTGGGCAATACTTTTGTGGTAATCATTTTTAGTACACCATAAAGTTATATCTTTTCCATAAAATAGATGTTATGTTTAAGGGCATTTTTTATAAATTTATTAATTAAGAAG
ATGGTTAGCTGGGTGCTTTTTAGCGCAGTGCATGTCAAACCGGGACATTTGCGATGGGTGCCTGTGAGCAGGAAAT
CTTTTCTTTGCGGCCTGTCTGATTTTGGCCAAGACAAATAAATCCGGCTGGGAGATAAGAAGAGGGGATCCGGCGG
TCAGGGCCATGGACATTGAACTTGAAAACGCAGAAAGCGCAGAAAACATTGTGTTTAACGAACGACAAATGCTGT
GCGGTGGTGTGTCGTTGGCTAAGGTTAGGGGAGTTTGGCAACAGGTTTCCACTTGCCAATGATAGATGGAAATCC
AAACTGGGGGGAGAAAATAAAAAGGAAAATGTTCAGGCTGCCATAAGTGGGAAAAAAGGAAAACAAAACATGA
AACACGGGCCGGGCAATGTCATCGCTTGTTTTCGCTTCGTTGTTTTCGCTTCGTTAGTTGATGTGCCTGT
GTGTAATAATGTCTAATGTTGCATGCCGGTTGCATAATCGTGTGGCAATTATGCCAAAGAGATTCGTTTATTTATT
TTTAATTTTTTTTATCATGTTCCGCTGCTACTATATTTTTTTGGCCACTTAGTGCGCCGCGCTTGATAATGATGTTTT
GTTTTCGCGTGCTGGCGCAAAGACAAACCCGTTTCAATTATTGGGAAAAGCGCGTATAAATCATCGCTGCTGAAA
TCTGCGAAACTGAAAAATGAAAACTGAAAAGTGAACCCAAAACAAACGCAAACAAACATAGCATCCCACACG
ACAAAATGAAAATCAAAATGGATATGAAAAACAGAAAAACGAGTCAATTCGATTTAAATTATAGGTTCAACGGCT
GCTGGCGATCGCATCATTAAATGCGCTTTCAGTGGATACTCGGCTGCGTTATGCAACAAACACACACAATTAATTA
ATAAAAGCGTACTGGTTATTTTAGCCGTGGCTTTTTATGGACCTGCCGATCGCAATAAATTTAAGCAGCATTAATC
GTAATTATGTGCAACATAGTTTCGGCTGCCGCGTGTCTCGGTCATTTTTCTGTGGGTGAGCCGAAGTCCAGAATGC
GGCCAAGGGATCAAGTTAAACCACTTTTCCGCACACCACACAGCTTTTTCGCATTTTGCATAATATTACCATAGCAT
AAACAGCGAAAACAAATGCCAAAAAATGAATAAAACGAGGAAAACAATTCAAAAATATTGTTAGAAGTATCATTC
ATAATGTTACCAGGTTTTTTTTTGTTAAGTGTCTAAGTAGAATTAAAAAAAAGAGAAGGTACGATTTTATTATT
TATTTACTAGGCAAATCGAATTCTTTGTCACCATTCTTGTTACGAAATTGTCTCCAAACATATTTGTTTTTCCTAGAC
TTGCTCAGACTTTAGTTGCACCTATCAAATAATAATACTTGTTTTGCGATATTTCACAAGATTTTCCTTAGTCAAA
GTGTAGATTGTGGGACTCCAGATTAATGCAAACCACTTCATCAGCTGAGGTCGTAAACGTATCTTTACCTATTTG
GTTCGTTCATTATGCGTGTGGTATAACGTTATTTTTTAGATTTTTCCTATTTTTTTTGCTAACCAGCTGCAGTTGGG
CCAAAGAGTTATGCGAACGCCTTCGGATTTTTTCGAGTTTTCACATTCACTTGCGGCGATGGCCATTAGAGCAA
ACCCACTTAGGGCGCCCCTAAAATCCAGGTGGTCCACAGGGACCACAACAGCATTGCAAATTACAGTCAGTTGAG
TGGAGTTACCGAAACGCACTTCTTTAATTTTGGCGGCCTTATGTAACTCTCGAATTGTATGTGCGATAAATATGCTA
AAAATCACCTGCTCATAATTAGCGGAAACCAAATGTTTGACCCTCGATGAATTGTGAATCATCGGAGCTGCCCAAT
CGAAATCAAAGCTAAACCATTCGAAGCCAGCCCAAGTAATTCATATTTATTGTTGTACAAGAAATACCCGCTCTGA
ATACTCTGTATCCATAAGCATTATACTAATATATAATTCATAACCATATCTGGTTTACTTACATACATATCATACAT
TATAGTTAAAGTGCACTAGCTATTTTTTTAGATTTTATATACACTTTACATATTTAAATACCATTTA
AAAATGAGACGCCTTTTAAAAAACCTTTTGAAGGAATTTACATTAGTCATATATAACCTTACAGCTTTAAATC
CTACTCCCCTAAAATACGTTATAAATAATCCAAAATTTGTTACCTTAGTAAAATAGTAAAATAAAAATGCCTCCAC
CCACTGTAAGTGAACCTAATGTTTTGTAGTTGATTTGCACATAAATCAGCAAATCCTAAATGTATATGAAGGCCA
GGAATTTCAAAGAATTCGGTGTGCCAAAAACCATACCCTTTCAAAATTATATGAAAAATGGCAAGTCCGGCGAAA
GGTGTGGCTGATTCAGTGAATTCGGAGTTTTGAGATACTTGTATTTATTAAACACGCGTGAAAATCAATCACTGA
AGACAAAAGCCACGCACTAAAAAAAACATAAGTATCCGAAGTTGGCCGATCCATGGGTGACCAAATAGATCAT
ATAGTGGACCACGCCACCCGAACCGTTGAAAACAACCGAATCACTGAAACCACCGAAGTTGGCGCCTTCGTTTTC
GTTTTCATTGGCCTGCCTTCGTCTTCGGAGAAAAAAAACCTCATATAAAACGTGGCCGACATATTGTGGCCAACAG
TCGTAAGCGCGCCACGGTCCACAGAAGAGG

>pRedSA-y 5'tak

AACCTACCCATCCAGCTGGTAATTCCACAGAAAACCAAAAAATAAACTACACCACCCCACTTAGAACTCCGTTT
AGCAGCAGTTGTTCAAACAGAAATAGTTGGCTTCGGCCGGTTCAGCTTCAGTTGATAATTATTAATATTTTAG
TTGTTGCTGCTGCTGCCTATCGCTAAATTTTTAATTGCTGAAGACAAAGGCACAGTTTTTATGCATAATTAGAG
GCTTACAATTTGTGTTTCAGCACACACAGTCCTTCACATTGCCAAAAGAAATACAAAGAATACAATATAATAAAAT
AAAAATTATAACACTAATTACACTCGAAAAAGCAGCGGGATCGTTTCACCACAATCGATCGATATTTAACCTGG
ACGAGTTCAACCACTCCCGCTGATAATTGCCAAGTTCTGTAATTGGAACTTTTCAAGATGATGTTGTTCTCTGCT
CAAGTTCTTAAGATTACCAACATAATAGTGAAAAATTAAGGAAATCACAAGCTTTAACTAATTAGTTGAACAATCT
TTATACACAGACAAAAAATTGACAAAAGATCAGATCAGGTCTGGTCAATTTTATATCACACCATATCATTTCATAT
GAATAAAGATTATGTTTATGTTCTTTTACATTATTTGTCTAAAAAATACTCAATTTGGTATTTTATATGATATGATTA
AATATCAAGTTGATATGTTTGAATCATACATTTGACATTAACCATATCAGCCCTATTTCAGTTAGAGTTTTTTCTAT
GCATATAAAACTTAATTGAATTTATGATTTAAGGAATCAAGGCCAAGCAATATCTTTTACATTTTCTGTGCCAATAC
TAGAATTCATGTATATTTATTTTTGAATGCCACACAACTTGAAATCGAGGAAGTACCATCTCGTATCTTCCAGAAA
AGTTGCCAAATGGCTAATGATACCATAAGCCAGGAGGAAGCCGAATAACAGTCGCTTAGCTGTTGCGATTTAAAT
AGTTTTTAATTGATAACTAATTGCGGCGAGGCGAGTGCCAAAACAAGACAGTGGACGACATGGCTGTGACGTTTTC
AATGTTGCAACATGGGGCAGCATTGCAACTCTTTAGCCAGTTAATTGGCAGCAAAAGCGACAGCGGCAGCAGCAA
ATACAGCTTTTCACCAGGAAATCAATAAACGATAGTCAAGCGAAGAGAAAAAAGCAAGCACAACACGCACATCTC
AATTTCAGTAGCAGCAAAAAAAAATGGGGAGATAAAGATAAAGAAAAAGACAAAATAAAATAAAACCAACCCTGA
CCAGCTCAATTTCTCGTGCCAAAAACTTAAAGCAAATATAGCCCAGTTTTTGAATGTGAAAAGGTAAACAATGCTA
ATGCTGGCCGGAAAATACCCAGAAATAAATACACCTGAGTCTTAGTTTCCGATTTGTATAATGGATTGAACTATAAA
AGGCAGCCGTAGATAACTTTCTTCACTCACAACTCCAAAAGTATTCCATCATGAAGCTGTTCCAACAAATCATCTT
GGGTCTTGTGCTCATCTTCGCCATAATGAGTTCCTTGTCGACTGCTCAGCCGCTGGAGGATGATGACTCCCTAATTG
GGGACTCGGAATCGAATGAATCATCTGTGCCTGATGACGTCCAACAGGATTATCTCAATGTGGCCGACTACGTGAC
TGCTCCACCTCCATGGTGGTGAACTAGACATTTTTAAAATGATTTAAAAAATATTTTATTCCTTTTTTTGTTTTTAT
TTTATAAATTGATGTATTAAAATTACAAATAACTTATTGTTTTAATCAGATGCGGATCCTTTTTCCCTTTTTTATGTT
ATCATATTTTGATTTTAGCAAACAAATATTTCATATTTTGCTCACTTCAATTTTGATTTTGAAGTATCCACCAATAATT
TCGAAATCCTCTTTGTCATAAACCTAAAAAAAACCAGTTCGATTTATTTAACGATCAATTATCCTTAGTTCAGAAAG
TATAAGCTTTTCATGCCCCATTTTTTCCCGCTTACCTATAAAGACGTGTAACGAAATTTATTTTACGCCAATAAACCC
AGATTCAGTAAGTGCTTCTTTATGAATATTTTCCATTTAGTTATTTTAATTGAAAGCTACAAATTGTGGTTTCAAT
GTTTTGACTGCTGGCAAAAGCAGTTGTACATTAAAAATAAATATCCAATACTGCGGAACCGCGAACCCGAAACCAGTATGCCA
GTTAATGCAAAATATATAATTTACTTACACTTACACTTATCTTATTTTCTCGGACTGCCACGCCACAACTAATGGAA
ATGTTTGCCTTGAATAGATCGGGGCGATTATTAATCGATTATCGCCCGATTACCACATTGAGTGGCTTAAAGACCC
ATAAGAAATGCAACTCGTCAACTCGGCTGATGGCTTAAGATAAATAAGTCGCCGAGTCGCTCATAAATTTCGAATG
CAGCCCGCTGATTTATGCACTCCAACTTCAGATTCAGATTCAGCTTCAGTCCGATGGAAATACTATTACCATTAAGC
GTTTTTCGACCACGGATTTTCCGCTTGCATGAGACAAGTCACCGCAATTGCAGGCAAATTATGTCTGAGGCAAT
GTTCGTCGTGCTCGTGTGTTTCGTGCAAGTTTACACAGAAATCAAATTACACGGCAACCTCTACTCACAATTCACTT
AGATGCTTAGTTTACTTTTCGCGCAGTGAACAAACAATGCCTTTTATTGGCATCTTATTTGCGCCATTTAGGGATGC
AATTTTCTGAGCTAAAACACTTTTAAGAAGGGATCTAAATTTCTCTTGTTTTGGCTTGAATAAATTTGGCGAATTCC
TCGTCGGCAATTTAAATACACATAAGGTGGACTAATCGCAAATCTTGTGTTTTAATTTAAATACAATATTGGTTAA
GACATTTGTAATTAGCCATAACTCACTTAAAGAGCGAAATAAATTCTTTTTTTGACTTGAATAAATTAAGGACATT
TCGAGTTGAGTATTTGAATTACACAAAAGGGGCTGCTTTGAAATTTTGGCTATTCTTTGTTTTGTAAATAAATAA
AAATAAATAAATAAAAAAACTTCAAACGCAATACCAGAACTTTACCATGCGCATATAGATTTTATAAAATAGTT
ACGAGCATAAAAAACTTTTCCTTTGGTGCTTGAAGTTTTTTGTCTTTTTTCCTGAGAAATATTAAATTATACAAA
ATAAGTAAGTAGAGGATTAATTATAGTCATTTCTCACCGCAGTGCATGTCAAACGTGGACATTTTCAATGGGTG
CCTGCCTGTGCCTGTGAGCAGGAAATCTCCGCGGCTTGTCTGATTTTGGCCAAGACAAATAAATCCGGCTGATAAA
TAaAATAaaaaAGAAGGAGGGGACCCGGCGGTCAGGGCCATGGACATTGAACTTGAAAATGATGAAAATGCTGGTA
AAACGCTGGTAAAACATCCAACGAAACGAACGGCAAATGCTGTGTGTGCTTTTGGTTTCGGCTAAGGTTAGAGCA
GTTGAGCAACAGGTTTCCATTTGCCATGGAAGATGGAAATCCAAACTGGGGGGAAAAAAAaGAAAAATGTTCAG
GCTGCCATAAGTGAAGAAAAGGAAAACAAAACATGAAACACGGGCCGGGCAATGTCATTCGGCATTTGGTTTTA
TTTCCGCCCAAGTTGAAGTGATCCTGTGTGTAAATAATGTCTAATGCTGCCTGCCGGTTGCATAATCGTGTGGCAA
TTATGCCAAAGAGATCCGTTTATTTCTTTTTTTTATACATTTCGTTTTTGGCCACTTAGCGCGCTTTGCCGCTTTGC
CACTTGATAATGTTGTTTTGTTTCTCGTGTGTGGCGCAAAACAAACTCGTTTCAATTATTGGGAAACGCGTA
TAAATCATAGCAGTTAGCGCTGAAATCTTTGAAAACTGCGAAAACTGAAAACTGTAACCCAAAACAAACCAAAAT
ACGAGTACAAACAAACATCCCACACGACAAAATCAACAAAATAGAGACGAAAAATACTGAAAAACGAGTCAAT
TCGATTTAAATTATAGGTTCAACGGCTGCTGGCGATCGCATCATTAAATTGCGCTTTTCAGTGGATACACGGGGTGG
CTTCGTTATGCAACATATATACTACACACACAATTAATATAAAACGTACTGGTTATTTTGAGTGAGGCTTTTTA
TGGACCTGCCGATCGCAATAAATTTAAGCAGCATTAGCCGTAATTATGTGCAACATATTTTTCGTTGCCGCGTGTT
TTTCTGTTTGTGTTTACTATTCCGTGGGTGAGTCAAGATCTAGAATGCGGCCAAGGGATCAAGTTGAACCACTTTTT
CGGCCACATAATATTTTACACATTTTGCATACAATTAGCATCGCATGAAATGCGAAACCAATGCCAAAAAAATTC
CAAAAATACTGAAAAAATTTTTGGTTTTATATTTAGAACATTTTTTTGTAAATATTTGTAATAAATAAAAAATA
CTATGAGAACCACATCGATTTTAATTTTCCTAGTTTTTATTTCCTAGCCCTGCTCACAAAATAACAAAAAAATTTGT
ATCAATTAAATAATTTTCCTTAAATATTTTTGCGAGCCACAACTTTCCCTTACTCAACGTGTAGATAGTGTGATTCC
AGATTAATGCAAACCACTTCATCAGCGGAGGTCGTAAAACGTATCTTTACCTATTTGGCTTGTTCATTATGCGTGTG
GTATTGCTTTTGCTGACCAGGTGCAGAAGTTGGGTTAAAATAGTTACATATGCGAACGCCTTCGGTCCGTTTTTTTA
TGGATTTTCACCTCGCTTGTGGCGATGGCCATTAGAGCATTACCCACTTAGGGCTCCCTAAAAATCCAGGTGGT
CCACAGGGACCACAAAAAATATTGCAAATTACACAGACACTTGAGTGCTTCCTTAATTTTTTTCGAACACTTTACTTA
TGTAACTCTCAAATTGTGTGTACGAAATGAAATGTATGCTAAAAATCACCTGCCCATAATTAGCGGAAACCAACTG
TTTGACCCTCGGTGAATTGTGAATCATCGGAACTGCCCAATCGAAATCAAAGCTAAACCAATCGAAACCAGCCCA
AGTAATTCCAATTTAATGCTGTCCAAGAAATACCTGCTTTGTATACTCTTTATCTTTTTATGGTTACATTAAAAAATT
ATACTAATATCGTGCTTATTTGCATATGTCATTAAAAATTATTAAGTGCACTGGTCTTATAAATTGAACATAATTAT
CCACCGGGCTAAAAAAAATAATGAGTTATAATTAAATCTGACTTTCTAAAATTAAAAAATAATTAACCTGTTTCTC
AACTAATTTTGAGAGATATTATAATCAAATATTTTGAGAACTGACTGCCGTTTACATTTTTTTGAAGATGTCACA
ATAATGTATTAAGCTTAAAGCTTTAAAATATTTGCAACAAAGAATTTACAAGTTTTTTTGAACGAAGCCATCCGT
TTTTGGTATGAAAGCCGAAAACTGCATTTTATGCACAAACCTGCCAGCCTAAAAGTGTGCTCAAAAATAGTATGAA
TACCAATTGAATGAATATACCTTGGTAAAAAATATTTCTAACTTTTATTATATTTAACAAATGCTGTACATCAACTT
AAAATATTGTAATTAATCTGCCCATAAATCAACAAAATCTCAAATTCAGCTGAAGGCCAGGAATTCAGAGAATTC
AGTGTGTGCCAAAAGCCAAAAACCAAAAAACCCTTTCAAAAGTGTATGAAAAATTGGCAAGCCCAGCGAAAGGTG
CTGCTGGCTGACTCGGTGAATTTTGAGGGTTCGACGAGATACTAGTATTTATTAAAACATGCGTGAAAATCAATCA
CTGAATACAAAAGCCACGCACTAAAAAATAAATGCCCGAAGTTTAGACCAACAGCCGAACCACTGAAACCACCGA
ACCACCGAAGTTGGCGCCTTCGTTTTCATTGGCCCAAGTCTTCGTC

P-series

>P1

GCAATCACTTCAATTTTCGTTTTTAATATTTCGAAATCATCTTTTTCATAAACCCCAAAAAACCAGTTTTTTTTTTTT
TAACGATCAATTATCCTTAGTTCAGAAAGTATTAGCTTTTCATGCCGATTTTTTCCCGCTTACCTATAAATACTTGTA
ACGAAATTTATTTAAGCCAATAAACCCAGATTTAGTAAGTGCTTCTTTATGAATATTTTCCATTTAGTTATTTTAATT
GAAAGCTACAAATTGTGGTTTCAAATGTTGTGACTGCGGAACCGACGAACCACTACCAGTTAATGCAAAATATAT
CATTCGCATTTACTTACACTTACACTTATCTTATTTTCTCGGACTGCCACGCCAACTAATGGAAATGTTTGCCTTGA
AtAgATCGGGCGATtATTAATCGATTATCGCCCGATTACCACATTGAGTGGCTTAAAGACCCATAAGAAATGCAAC
TCGTCAACTCGGCTGATGGCTTAAGATAAATAAGTCGCCGAGTCGCTCATAAATTTCGAATGCAGCCCGCTGATTT
ATGCACTCCAACTTCAGCTGGATGGAAATACTATTACCATTAAGCGTTTTTCGACCACGGATTTTCCGCTTGCATG
AGACAAGTGCACCGCAATTGCAGGCAAATTATGTCGAGGCAATGTTTCGTGCTCGTGTGTTTCGTGCAAGTTTACA
CAGAAATCAAATTACACGACAACCTCTACTCAATTCACAATTCACTACTTACTTGCTTAGTTTACTTTTCGCGCAGT
GAACAGACAATGCCTTTTATTGGCATCTTATTTGCGCCATTTAAGGATGCAATTTTCTGAGCTAAAACACATTTAAG
GAGAGATCTAAATTTCTCTTGTTTTGGCTTGAATAAATTTAACGAATTCCTTGTCGACTATTTAAATACACATAAGG
TGGGGGCTCTCGCATATCTTGTGTTTTAATTTAAATACAATATTGGTTAAGACATTTGTAATTAGCCAAAAACTCAC
TAAAGGAGCGATCTAAATTTCTCTTTTTTTGGCTTGAATAAATTAAGGACATTCCAAGTTGAGTATTTAAATTACAC
AAAAGGAGCTGCTTTGAAATCTTGTCTTTTTCTTTGTCTAGTTAAATAGAATATTGGTAAGTAATGTTGTAATGTT
ATGTGGTATTAATTTTGACATGATACGCGGTTATCTCAGTTCGATATGCTCGAAATGTAAATAACAGCCAGTTCTA
ATTTCGAATGTGTCTTTCTCACTCCCACTCGCGTAATTTAAGTCGCCACATTGCTTTTTCCTCTCTTTTTCGAAGACA
GAGAATCTCCGAGAGAGAGATTCGGTAAAAACGCAATACCAGAAATTTATCATGCGCATATCGATTTGACCGCTT
CTTTTTTTGTGTGTAAGAAAGCTTATTATTACATTATTCATAATATTTATTTTATTTTATGGATTTAATAAAATAGT
TACGAGCATAAAACTTTTATTTTGGTGCCCTCAAATGTTCCTCCACTTTTTTTGTAGTACGAATATTCGTAAAAAT
GTATACAGAGTTTATAGAGTTTAATATAAAATAATTCGCAATTAAAGAGCACTAATTGTAGTGCATTTCACCGCAG
TGCATGTCAAACGTGGACATTTGCAATGGGTGCCTGTGTGCCTGTGAGCAGGAAATCTCCGCGCTTGCTGATTT
TGGCCAAGACAAATAAATCCGGCTGATAAATACAAGAAAAAGAAAAAAAGGAGGGGATCCGGCGGTCAGGGCC
ATGGACATTGAACTTGAAAATGCTGAAAACGCTGGTAAAAACATCCAACGAAACGAACGGCAAATGCTGTGTGT
GTGTCTTTGGTTTTGGCTAAGGTTAGAGCAGTTGAGCAACAGGTTTCCATTTGCCATTTGCCAATGGAAGATGGAA
ATCCAAACTGAAAAAAAGAAAAAATGTTCAGGCTGCCATAAGTGAAGAAAAAGGAAAAACAAAAACATGAAACACGG
GCCGGGCAATGTCATTCGGCATTTGGGTTTTATTTTCCGCCCAAGTTGAAGTGATCCTGTGTGTAAATAATGTCTAAT
GTTGCCTGCCGGTTGCATAATCGTGTGGCAATTATGCCAAAGAGATCCGTTTATTTTCTTTCTTTTTTCACATTTCG
TTTTTTGGCCACTTAGCGCGCTTGCCGCTTGCCACTTGCCACTTGATAATGTTGTTTTGTTTCTCGTGAGCAAAAA
AAAACCCCAAACTCGTTTCAATTATTGGGAAAAGCGCGTATAAATCATCGCTGCTAGCGCTGAAATCTTTGAAAAC
TGCGAAAACTGAAAACCTGAAAAACAAAAACCGAAACACAAAAACACGCCGCATCCATCCCAACACGA
CAAAAATCAACGAAAAAAACTGAAAAACGAGTCAATTCGATTTAAATTATAGGTTCAACGGCTGCTGGCGATCGC
ATCATAATTGCGCTTTTCAGTGGATACACGGGTGGCTTCGTTATGCAACATTTATACTACACACACAATTAATTAA
TAAAAACGTACTGGTTATTTTAAGTGTGGCTTTTTATGGAGCTCCCGATCGCAATAAATTTAAGCAGCATTAGCCGT
AATTATGTGCAACATATTTTCGGTTGCCGCGTGTTTTCTGTTTCTGTTTACTTTTCCGTGGGTGAGTCAAGATCTA
GAATGCGGCCAAGGGATCAAGTTGAACCACTTTTTCGGCCACCATAATATTTTTACACATTTTGCATAAAATTAGC
ATCGCATAAATTGCGAAAACAAATGCTAAAAAATTACAAAAAATTAACAAAAATTGCGAAAAAAAAAATGTCAAAAT
ATATATATATTTTTAACATTTATTTTGAGTTCTAAAAAATAGCTTTAATAATATTTGACAAAATATTTTCCTTTAA
TATTTTTTAGAACATTTATTTTGAGATCTAAAAAATAGTTGTAATAATTTTCGACTAAATATTTGCCCTTAATATT
TTTTTGAGCCCCAACTTTTCCTTACTCAACGTGTAGATTGTGTGATTCTAGATTAATGCAAACCACTTCATCAGCGG
AGGTCGTAAAACGTATCTTTACCTATTTGGCTTGTTCATTATGCGTGTGGTATTACTTTATTTTTTTTTTTGCAGAC
CAGGTGCAGTTGGGTTAAAATAGTTACATATGCGAACGCCTTCGGTGCGAATTTTTTTTCTTGGATTTTCACATTCA
CTTGCGGCGATGGCCATTAGAGCATTACCCACTTAGGGCTCCCCTAAAAATCCAGGTGGTCCACAGGGACCACAA
AAATTATGCAAATTACAGGCCTTTACCTTTGAACACAAAAACACGCCGCATCCATCCCAACACGA
GTACGAAATGAAATGTATGCTAAAAATCACCTGCCCATAATTACGCGGAAACCACTTTTTGACCCTCGGTGAATT
GTGAATCATCGGAACTGCCCAACTGCCCAATCGAAATCAAAGCTAAACCAATCGAAACCAGCCCAAGTAATCAA
ATTTAATGCTGTTCAAGAAATACCTGCTTTGTATACTCTATCTATACGATTTACTATAATGATAAATTATACTAATA
TCTGGCTTATTTGCATATATGTCATAAAATAGAAATAAGTGCACTGGTCATATAAATTGAACATATTTATCAACGG
GCTTTCAAAAAATAATGAGAAATAATTAAATCTGACTTTCAAAAATTACAAATTAAATTACTGTTTTTTTTTTTAAT
AACTTTGAAAGTTGTTTATAGATAAAATATTTTTGAAGATGTCACACTGATATTAAGCTTAAAGCTTTAAAATAT
TTTGCAACAAAGAATTTTACAAGTTTTTATTAAACGGAGCCGTTCCGTTTTTGGTGCGAAAGCCGAAAATTGCATTT
TATGCACAAACCTGCCAGCCTAAAAAGTGTGCTCAAAAATAGTATGAATACTAAATGAATGAATAACCCTGGTAA
AAATAATGTCTAACTTGAGTTCCATTATATTTATTAAATATACAGTACAGCAATATACATACTTTTAGTCTTTAAG
AAATCAATGTTTGTAATGTCATCCAGCTTTAATGTATTTTGCAATAGAACAATGTAGTTAAGAAATTTATTTATGTT
CATGAATCTGACAAATTGTGACTAGCGCTTTAATTTATAAGTATTTTTGTACTGTAGCGTTAGGAAGAAATAAA
ACCAAAATTAAATTAAAAATATACAGCAACTTTATATTTGTAATTAATTTACTCATAAATCAGCAAAATCTCAA
TTCAGCTGAAGGCCAGGAATTTCAAAGAATTCAGCGTGCCAAAAACCAAAAAACCCTTTCAAAAGTGTATGAAAA
ATTGGCAATCCCAGCGAAAGGTGACTCGGCTGACTCGGTGAATTTTGAGGGTTCGAGATACTCGTATTTATTAAAA
CATGCGTGAAAATCAATCACTGAATACAAAAGCCACGCACTAAAAAATAAATGCCCGAAGTTTAGACCACCACCG
GCCGAACCACTGaAACCA

> P2

TCCTTAGTTCAGAAAGTATTAGCTTTTCATGCCGATTTTTTCCCGCTTACCTATAAATACTTGTAAACGAAATTTATTT
AAGCCAATAAACCAGATTTAGTAAGTGCTTCTTTATGAATATTTTCCATTTAGTTATTTTAATTGAAAGCTACAAA
TTGTGGTTTCAAATGTTGTGACTGCGGAACCGACGAACCACTACCAGTTAATGCAAAATATATCATTCGCATTTA
CTTACACTTACACTTATCTTATTTTCTCGGACTGCCACGCCAACTAATGGAAATGTTTGCCTTGAAtAgATCGGGGCG
ATtATTAATCGATTATCGCCCGATTACCACATTGAGTGGCTTAAAGACCCATAAGAAATGCAACTCGTCAACTCGGC
TGATGGCTTAAGATAAATAAGTCGCCGAGTCGCTCATAAATTTCGAATGCAGCCCGCTGATTTATGCACTCCAACT
TCAGCTGGATGGAAATACTATTACCATTAAGCGTTTTTCGACCACGGATTTTCCGCTTGCATGAGACAAGTGCAC
CGCAATTGCAGGCAAATTATGTCTGAGGCAATGTTCGTGCTCGTGTGTTTCGTGCAAGTTTACACAGAAATCAAAT
TACACGACAACCTCTACTCAATTCACTTACTTCTCAGTGCAACAGACAATGCAACAGTTCCTTTTACCGCCATTTT
CCTTTTATTGGCATCTTATTTGCGCCATTTAAGGATGCAATTTTCTGAGCTAAAACACATTTAAGGAGAGATCTAAA
TTTCTCTTGTTTTGGCTTGAATAAATTTAACGAATTCCTTGCGACTATTTAAATACACATAAGGTGGGGCTCTCG
CATATCTTGTGTTTTAATTTAAATACAATATTGGTTAAGACATTTGTAATTAGCCAAAAACTCACTAAAGGAGCGA
TCTAAATTTCTCTTTTTTGGCTTGAATAAATTAAGGACATTCCAAGTTGAGTATTTAAATTACACAAAAGGAGCTG
CTTTGAAATCTTGTCTTTTTCTTTGTCTAGTTAAATAGAATATTGGTAAGTAATGTTGTAATGTTATGTGGTATTAA
TTTTGACATGATACGCGGTTATCTCAGTTCGATATGCTCGAAATGTAAATAACAGCCCAGTCTAATTTCGAATGTG
TCTTTCTCACTCCCACTCGCGTAATTTAAGTCGCCACATTGCTTTTTCCTCTCTTTTTCGAAGACAGAGAATCTCCGA
GAGAGAGATTTCGGTAAAAACGCAATACCAGAAATTTATCATGCGCATATCGATTTGACCGCTTCTTTTTTGTGTG
TAAGAAAGCTTATTATTACATTATTCATAATATTTATTTTATTTATGGATTAATAAAATAGTTACGAGCATAAA
AACTTTTATTTTGGTCCTCAAATGTTCCTCCACTTTTTTTGTAGTACGAATATTCGTAAAAATGTATACAGAGTTT
ATAGAGTTTAATATAAAATAATTCGCAATTAAGAGCAATAATTGTAGTCATTTCACCGCAGTGCATGTCAAACG
TGGACATTTGCAATGGGTGCCTGTGTGCCTGTGAGCAGGAAATCTCCGCGGCTTGTCTGATTTTGGCCAAGACAAA
TAAATCCGGCTGATAAATACAAGAAAAAGAAAAAAAGGAGGGGATCCGGCGGTCAGGGCCATGGACATTGAAC
TTGAAAATGCTGAAAACGCTGGTAAAACATCCAACGAAACGAACGGCAAATGCTGTGTGTGTGTGTCTTTGGTTTG
GCTAAGGTTAGAGCAGTTGAGCAACAGGTTTCCATTTGCCATTTGCCAATGGAAGATGGAAATCCAAACTGAAA
AAAAGAAAATGTTCAGGCTGCCATAAGTGAAGAAAAGGAAAACAAAACATGAAACACGGGCCGGGCAATGTC
ATTTCGGCATTTGGTTTTATTTTCCGCCAAGTTGAAGTGATCCTGTGTGTAAATAATGTCTAATGTTGCCTGCCGGT
TGCATAATCGTGTGGCAATTATGCCAAAGAGATCCGTTTATTTTCTTTCTTTTTTTCACATTTCGTTTTTTGGCCACT
TAGCGCGCTTGCCGCTTGCCACTTGCCACTTGATAATGTTGTTTTGTTTCTCGTGGAGCAAAAAAAAACCCCAAACT
CGTTTCAATTATTGGAAAAGCGCGTATAAATCATCGCTGCTAGCGCTGAAATCTTTGAAAAACTGCGAAAACTGAA
AACTGTAACCCAAAACAAACCAAAACCGAAACACAAACACCGCCGCATCCATCCCACACGACAAAAATCAACGA
AAAAACTGAAAAACGAGTCAATTCGACCATTAAATTATAGGTTCAACGGCTGCTGGCGATCGCATCATTAATTGCGC
TTTTCAGTGGATACACGGGTGGCTTCGTTATGCAACATTTATACTACACACACAATTAATTAATAAAACGTACTG
GTTATTTTAAGTGTGGCTTTTTATGGAGCTCCCGATCGCAATAAATTTAAGCAGCATTAGCCGTAATTATGTCAAC
ATATTTTTCGGTTGCCGCGTGTTTTTCTGTTTCTGTTTACTTTTCCGTGGGTGAGTCAAGATCTAGAATGCGGCCAAG
GGATCAAGTTGAACCACTTTTCGGCCACCATAATATTTTACACATTTTGCATAAAAATTAGCATCGCATCAATTGC
GAAAACAAATGCTAAAAAATTACAAAAAATTAACAAAAAATTGCGAAAAAAAAAATGTCAAAATATATATATATATTTTT
TAACATTTATTTTGAGTTCTAAAAAAATAGCTTTAATAATATTTGACAAAATATTTTCCTTTAATATTTTTTTAGAAC
ATTTATTTTGAGATCTAAAAAAATAGTTGAATAATTTTCGACTAAATATTTGCCCTTAATATTTTTTTGAGCCCCA
ACTTTTCCTTACTCAACGTGTAGATTGTGTGATTCTAGATTAATGCAAACCACTTCATCAGCGGAGGTCGTAAAAC
GTATCTTTACCTATTTGGCTTGTTCATTATGCGTGTGGTATTACTTTATTTTTTTTTTTTGCAGACCAGGTGCAGTTG
GGTTAAAATAGTTACATATGCGAACGCCTTCGGTGCGAATTTTTTTTCTGGATTTTCACATTCACTTGCGGCGATG
GCCATTAGAGCATTACCCACTTAGGGCTCCCTAAAAATCCAGGTGGTCCACAGGGACCACAAAAATATTGCAA
TTACAGGCACTTGAGTGCTTCCTTAACTCTTTGAACACTTTACTTATGCAACTCTCAAATTGTATGTACGAAATGAA
ATGTATGCTAAAAATCACCTGCCCAATTACGCGGAAACCAACTTTTACCCCTCGGTGAATTGTGAATCATCGG
AACTGCCCAACTGCCCAATCGAAATCAAAGCTAAACCAATCGAAACCAGCCCAAGTAATTCAAATTTAATGCTGTT
CAAGAAATACCTGCTTTGTATACTCTATCTATACGATTTACTATAATGATAAATTATACTAATATCTGGCTTATTTG
CATATATGTCATAAAATAGAAATAAGTGCACTGGTCATATAAATTGAACATATTTATCAACGGGCTTTCAAAAAAT
AATGAGAAATAATTAAATCTGACTTTCAAAAATTACAAATTAAATTACTGTTTTTTTTTTTAATACTTTGAAAGTT
GTTTATAGATAAAATATTTTTGAAGATGTCACACTGATATTAAGCTTTAAAGCTTTAAAATATTTTGCAACAAAG
AATTTTACAAGTTTTTATTAAACGGAGCCGTTCCGTTTTTGGTGCGAAAGCCGAAAATTGCATTTTATGCACAAACC
TGCCAGCCTAAAAGTGTGCTCAAAAATAGTATGAATACTAAATGAATGAATAACCCTGGTAAAAATAATGTCTA
ACTTGAGTTCCATTATATTTATTAAATATACAGTACAGCAATATACATAACTTTTAGTCTTTAAGAAATCAATGTTT
GTAATGTCATCCAGCTTTAATGTATTTTGCAATAGAACAATGTAGTTAAGAAATTTATTTATGTTCATGAATCTGAC
AAATTGTGACTAGCGCTTTAATTTATAAGTATTTTTGTACTTGTAGCGTTAGGAAGAAATAAAACCAAAATTAAA
TTAAAAATATACAGCAACTTTATATTTTGAATTAATTTACTCATAAATCAGCAAAATCTCAAATTCAGCTGAAGG
CCAGGAATTTCAAAGAATTCAGCGTGCCAAAAACCAAAAAACCCTTTCAAAAGTGTATGAAAAATTGGCAATCCC
AGCGAAAGGTGACTCGGCTGACTCGGTGAATTTTGAGGGTTCGAGATACTCGTATTTATTAAAACATGCGTGAAAA
TCAATCACTGAATACAAAAGCCACGCACTAAAAAATAAATGCCCGAAGTTTAGACCACCACCGGCCGAACCACTG
AACCA

>P3

ATTAATCGATTATCGCCCGATTACCACATTGAGTGGCTTAAAGACCCATAAGAAATGCAACTCGTCAACTCGGCTG
ATGGCTTAAGATAAATAAGTCGCCGAGTCGCTCATAAATTTCGAATGCAGCCCGCTGATTTATGCACTCCAACTTC
AGCTGGATGGAAATACTATTACCATTAAGCGTTTTTCGACCACGGATTTTCCGCTTGCATGAGACAAGTGCACCG
CAATTGCAGGCAAATTATGTCTGAGGCAATGTTCGTGCTCGTGTGTTTCGTGCAAGTTTACACAGAAATCAAATTA
CACGACAACCTCTACTCAATTCACAATTCACTACTTACTTGCTTAGTTTACTTTTCGCGCAGTGAACAGACAATGCC
TTTTATTGGCATCTTATTTGCGCCATTTAAGGATGCAATTTTCTGAGCTAAAACACATTTAAGGAGAGATCTAAATT
TCTCTTGTTTTGGCTTGAATAAATTTAACGAATTCCTTGTCGACTATTTAAATACACATAAGGTGGGGGCTCTCGCA
TATCTTGTGTTTTAATTTAAATACAATATTGGTTAAGACATTTGTAATTAGCCAAAAACTCACTAAAGGAGCGATCT
AAATTTCTCTTTTTTTGGCTTGAATAAATTAAGGACATTCCAAGTTGAGTATTTAAATTACACAAAAGGAGCTGCTT
TGAAATCTTGCTCTTTTTCTTGTTAAGTAAATAGAATATTGGTTAATGTTGTAATGTTGTATAATTT
TGACATGATACGCGGTATCTCAGTTCGATATGCTCGAAATGTAAATAACAGCCCAGTTCTAATTTTCGAATGTGTCT
TTCTCACTCCCACTCGCGTAATTTAAGTCGCCACATTGCTTTTTCCTCTCTTTTTCGAAGACAGAGAATCTCCGAGA
GAGAGATTCGGTAAAAACGCAATACCAGAAATTTATCATGCGCATATCGATTTGACCGCTTCTTTTTTTGTGTGTA
AGAAAGCTTATTATTACATTATTCATAATATTTATTTTATTTTATGGATTTAATAAAATAGTTACGAGCATAAAAA
CTTTTATTTTGGTCCTCAAATGTTCCTCCACTTTTTTTGTAGTACGAATATTTCGTAAAAATGTATACAGAGTTTAT
AGAGTTTAATATAAAATAATTCGCAATTAAAGAGCACTAATTGTAGTGCATTTCACCGCAGTGCATGTCAAACGTG
GACATTTGCAATGGGTGCCTGTGTGCCTGTGAGCAGGAAATCTCCGCGGCTTGTCTGATTTTGGCCAAGACAAATA
AATCCGCTGATAAATACAAGAAAAAGAAAAAAAGGAGGGGATCCGGCGGTCAGGGCCATGGACATTGAACTT
GAAAATGCTGAAAAACGCTGGTAAAACATCCAACGAAACGAACGGCAAATGCTGTGTGTGTGTGTCTTTGGTTTGG
CTAAGGTTAGAGCAGTTGAGCAACAGGTTTCCATTTGCCATTTGCCAATGGAAGATGGAAATCCAAACTGAAAA
AAAGAAAAATGTTCAGGCTGCCATAAGTGAAGAAAAGGAAAAACAAAACATGAAACACGGGCCGGGCAATGTCA
TTCGGCATTTGGTTTTATTTCCGCCCAAGTTGAAGTGATCCTGTGTGTAATAATAATGTCTAATGTTGCCTGCCGGTT
GCATAATCGTGTGGCAATTATGCCAAAGAGATCCGTTTATTTCTTTCTTTTTTCACATTTCGTTTTTTGGCCACTT
AGCGCGCTTGCCGCTTGCCACTTGCCACTTGATAATGTTGTTTTGTTTCTCGTGAGCAAAAAAAACCCCAAACTC
GTTTCAATTATTGGGAAAAGCGCGTATAAATCATCGCTGCTAGCGCTGAAATCTTTGAAAACTGCGAAAACTGAAA
ACTGTAACCCAAAACAAACCAAAACCGAAACACAAACACCGCCGCATCCATCCCACACGACAAAAATCAACGAA
AAAAACTGAAAAACGAGTCAATTCGATTTAAATTATAGGTTCAACGGCTGCTGGCGATCGCATCATTATTCGCT
TTTCAGTGGATACACGGGTGGCTTCGTTATGCAACATTTATACTACACACACAATTAATTAATAAAAACGTACTGG
TTATTTAAGTGTGGCTTTTTATGGAGCTCCCGATCGCAATAAATTTAAGCAGCATTAGCCGTAATTATGTGCAACA
TATTTTCGGTTGCCGCGTGTTTTTCTGTTTCTGTTTACTTTTCCGTGGGTGAGTCAAGATCTAGAATGCGGCCAAGG
GATCAAGTTGAACCACTTTTTCGGCCACCATAATATTTTTACACATTTTGCATAAAATTAGCATCGCATAAATTGCG
AAAACAAATGCTAAAAAATTACAAAAAATTACGCGAAAAACTAAAAATGTCAAAATATATATATATATATATTTTT
AACATTTATTTTGAGTTCTAAAAAAATAGCTTTAATAATATTTGACAAAATATTTTCCTTTAATATTTTTTAGAAC
ATTTATTTTGAGATCTAAAAAAATAGTTGAATAATTTTCGACTAAATATTTGCCCTTAATATTTTTTTGAGCCCCA
ACTTTTCCTTACTCAACGTGTAGATTGTGTGATTCTAGATTAATGCAAACCACTTCATCAGCGGAGGTCGTAAAAC
GTATCTTTACCTATTTGGCTTGTTCATTATGCGTGTGGTATTACTTTATTTTTTTTTTTGCAGACCAGGTGCAGTTG
GGTTAAAATAGTTACATATGCGAACGCCTTCGGTGCGAATTTTTTTTCTGGATTTTCACATTCACTTGCGGCGATG
GCCATTAGAGCATTACCCACTTAGGGCTCCCTAAAAATCCAGGTGGTCCACAGGGACCACAAAAATATTGCAAA
TTACAGGCACTTGAGTGCTTCCTTAACTCTTTGAACACTTTACTTATGCAACTCTCAAATTGTATGTACGAAATGAA
ATGTATGCTAAAAATCACCTGCCCATAATTACGCGGAAACCAACTTTTTGACCCTCGGTGAATTGTGAATCATCGG
AACTGCCCAACTGCCCAATCGAAATCAAAGCTAAACCAATCGAAACCAGCCCAAGTAATTCAAATTTAATGCTGTT
CAAGAAATACCTGCTTTGTATACTCTATCTATACGATTTACTATAATGATAAATTATACTAATATCTGGCTTATTTG
CATATATGTCATAAAATAGAAATAAGTGCACTGGTCATATAAATTGAACATATTTATCAACGGGCTTTCAAAAAAT
AATGAGAAATAATTAAATCTGACTTTCAAAAATTACAAATTAAATTACTGTTTTTTTTTTTAATAACTTTGAAAGTT
GTTTATAGATAAAATATTTTTGAAGATGTCACACTGATATATTAAGCTAAAAAGCTTTAAAATATTTTGCAACAAAG
AATTTTACAAGTTTTTATTAAACGGAGCCGTTCCGTTTTTGGTGCGAAAGCCGAAAATTGCATTTTATGCACAAACC
TGCCAGCCTAAAAGTGTGCTCAAAAATAGTATGAATACTAAATGAATGAATAACCCTGGTAAAAATAATGTCTA
ACTTGAGTTCCATTATATTTATTAAATATACAGTACAGCAATATACATAACTTTTAGCTTTAAGAAATCAATGTTT
GTAATGTCATCCAGCTTTAATGTATTTTGCAATAGAACAATGTAGTTAAGAAATTTATTTATGTTCATGAATCTGAC
AAATTGTGACTAGCGCTTTAATTTATAAGTATTTTTGTACTTGTAGCGTTAGGAAGAAATAAAACCAAAATTAAA
TTAAAAATATACAGCAACTTTATATTTTGAATTAATTTACTCATAAATCAGCAAAATCTCAAATTCAGCTGAAGG
CCAGGAATTTCAAAGAATTCAGCGTGCCAAAAACCAAAAAACCCTTTCAAAAGTGTATGAAAAATTGGCAATCCC
AGCGAAAGGTGACTCGGCTGACTCGGTGAATTTTGAGGGTTCGAGATACTCGTATTTATTAAAACATGCGTGAAAA
TCAATCACTGAATACAAAAGCCACGCACTAAAAAATAAATGCCCCGAAGTTTAGACCACCACCGGCCGAACCACTG
AACCA

> P4

TTGCTTAGTTTACTTTTCGCGCAGTGAACAGACAATGCCTTTTATTGGCATCTTATTTGCGCCATTTAAGGATGCAA
TTTTCTGAGCTAAAACACATTTAAGGAGAGATCTAAATTTCTCTTGTTTTGGCTTGAATAAATTTAACGAATTCCTT
GTCGACTATTTAAATACACATAAGGTGGGGGCTCTCGCATATCTTGTGTTTTAATTTAAATACAATATTGGTTAAGA
CATTTGTAATTAGCCAAAAACTCACTAAAGGAGCGATCTAAATTTCTCTTTTTTTGGCTTGAATAAATTAAGGACAT
TCCAAGTTGAGTATTTAAATTACACAAAAGGAGCTGCTTTGAAATCTTGTCTTTTTCTTGTTCTAGTTAAATAGAA
TATTGGTAAGTAATGTTGTAATGTTATGTGGTATTAATTTTGACATGATACGCGGTATCTCAGTTCGATATGCTCG
AAATGTAAATAACAGCCCAGTTCTAATTTTCGAATGTGTCTTTCTCACTCCCACTCGCGTAATTTAAGTCGCCACATT
GCTTTTTCCTCTCTTTTTCGAAGACAGAGAATCTCCGAGAGAGAGATTCGGTAAAAACGCAATACCAGAAATTTA
TCATGCGCATATCGATTTGACCGCTTCTTTTTTTGTGTGAAGAAAGCTTATTATTACATTATTCATAATATTTATTT
TTATTTTATGGATTTAATAAAAATAGTTACGAGCATAAAAAACTTTTATTTTGGTGCCCTCAAATGTTCCTCCACTTTTT
TGTAGTACGAATATTTCGTAAAAATGTATACAGAGTTTATAGAGTTTAATATAAAATAATTCGCAATTAAAGAGCA
CTAATTGTAGTCATTTCACCGCAGTGCATGTCAAACGTGGACATTTGCAATGGGTGCCTGTGTGCCTGTGAGCAG
GAAATCTCCGCGGCTTGTCCTGATTTTGGCCAAGACAAATAAATCCGGCTGATAAATACAAGAAAAAGAAAAAAA
GGAGGGGATCCGGCGGTCAGGGCCATGGACATTGAACTTGAAAATGCTGAAAACGCTGGTAAAACATCCAACGAA
ACGAACGGCAAATGCTGTGTGTGTGTTCTTGTTTGGCTAAGGTTAGAGCAGTTGAGCAACAGTTTTCCATTT
GCCATTTGCCAATGGAAGATGGAAATCCAAACTGAAAAAAAGAAAAATGTTCAGGCTGCCATAAGTGAAGAAA
AGGAAAACAAAACATGAAACACGGGCCGGGCAATGTCATTCGGCATTTGGTTTTATTTCCGCCCAAGTTGAAGTG
ATCCTGTGTGTAAATAATGTCTAATGTTGCCTGCCGGTTGCATAATCGTGTGGCAATTATGCCAAAGAGATCCGTTT
ATTTTCTTTCTTTTTTTCACATTTCGTTTTTGGCCACTTAGCGCGCTTGCCGCTTGCCACTTGCCACTTGATAATGTT
GTTTTGTTTCTCGTGGAGCAAAAAAAACCCCAAACTCGTTTCAATTATTGGGAAAAGCGCGTATAAATCATCGCT
GCTAGCGCTGAAATCTTTGAAAACTGCGAAAACTGAAAACTGTAACCCAAAACAAACCAAAACCGAAACACAAA
CACCGCCGCATCCATCCCACACGACAAAAAATCAACGAAAAAAACTGAAAAACGAGTCAATTCGATTTAAATTATA
GGTTCACGGCTGCTGGCGATCGCATCATTAATTGCGCTTTTCAGTGGATACACGGGTGGCTTCGTTATGCAACATT
TATACTACACACACAATTAATTAATAAAAACGTACTGGTTATTTTAAGTGTGGCTTTTTATGGAGCTCCCGATCGCA
ATAAATTTAAGCAGCATTAGCCGTAATTATGTCAACATATTTTCGTTGCCGCGTGTTTTTCTGTTTCTGTTTACT
TTTCCGTGGGTGAGTCAAGATCTAGAATGCGCCAAGGGATCAAGTTGAACCACTTTTTCGGCCACCATAATATTT
TTACACATTTGCATAAAATTAGCATCGCATAAATTGCGAAAACAAATGCTAAAAATTACAAAAAATTAACAAAA
ATTGCGAAAAAAAAAATGTCAAATATATATATATTTTTAACATTATTTTGAGTTCTAAAAAAATAGCTTTAATAA
TATTTGACAAAATATTTTCCTTTAATATTTTTTAGAACATTTATTTTGAGATCTAAAAAAATAGTTGTAATAATTTT
CGACTAAATATTTGCCCTTAATATTTTTTGAGCCCCAACTTTTCCTTACTCAACGTGTAGATTGTGTGATTCTAGAT
TAATGCAAACCACTTCATCAGCGGAGGTCGTAAACGTATCTTTACCTATTTGGCTTGTTCATTATGCGTGTGGTAT
TACTTTATTTTTTTTTTTTCAGACCAGGTGCAGTTGGGTTAAAATAGTTACATATGCGAACGCCTTCGGTGCGAAT
TTTTTTTCTTGGATTTTCACATTCACTTGCGGCGATGGCCATTAGCATTACCCACTTAGGGCTCCCCTAAAAATC
CAGGTGGTCCACAGGGACCACAAAAAATATTGCAAATTACAGGCACTTGAGTGCTTCCTTAACTCTTTGAACACTTT
ACTTATGCAACTCTCAAATGTATGTACGAAATGAAATGTATGCTAAAAATCACCTGCCCATAATTACGCGGAAAC
CAACTTTTTGACCCTCGGTGAATTGTGAATCATCGGAACTGCCCAACTGCCCCAATCGAAATCAAAGCTAAACCAAT
CGAAACCGCCCAAGTAATTCAAAGAAATCATGCTGTTCAAGAAATCATGCTCTTTGTATACTCTATCTATACGATTTAC
TATAATGATAAATTATACTAATATCTGGCTTATTTGCATATATGTCATAAAATAGAAATAAGTGCACTGGTCATAT
AAATTGAACATATTTATCAACGGCTTTCAAAAAATAATGAGAAATAATTAAATCTGACTTTCAAAAATTACAAAT
TAAATTACTGTTTTTTTTTTTAATACTTTGAAAGTTGTTTATAGATAAAATATTTTTGAAGATGTCACACTGATATA
TTAAGCTTAAAGCTTTAAAATATTTTGCAACAAAGAATTTTACAAGTTTTTATTAAACGGAGCCGTTCCGTTTTGG
TGCGAAAGCCGAAAATTGCATTTTATGCACAAACCTGCCAGCCTAAAAGTGTGCTCAAAAATAGTATGAATACTA
AATGAATGAATAACCCTGGTAAAAATAATGTCTAACTTGAGTTCATTATATTTATTAAATATACAGTACAGCAA
TATACATACTTTTAGTCTTTAAGAAATCAATGTTTGTAATGTCATCCAGCTTTAATGTATTTTGCAATAGAACAAT
GTAGTTAAGAAATTTATTTATGTTCATGAATCTGACAAATTGTGACTAGCGCTTTAATTTATAAGTATTTTTGTAC
TTGTAGCGTTAGGAAGAAATAAAACCAAAATTAAATTAAAAATATACAGCAACTTTATATTTGTAAATTAATTTAC
TCATAAATCAGCAAAATCTCAAATTCAGCTGAAGGCCAGGAATTTCAAAGAATTCAGCGTGCCAAAAACCAAAAA
ACCCTTTCAAAAGTGTATGAAAAATTGGCAATCCCAGCGAAAGGTGACTCGGCTGACTCGGTGAATTTTGAGGGTT
CGAGATACTCGTATTTATTAAAAACATGCGTGAAAATCAATCACTGAATACAAAAGCCACGCACTAAAAAATAAAT
GCCCGAAGTTTAGACCACCACCGGCCGAACCACTGAACCA

>P5

TGACATGATACGCGGTTATCTCAGTTCGATATGCTCGAAATGTAAATAACAGCCCAGTTCTAATTTCGAATGTGTCT
TTCTCACTCCCACTCGCGTAATTTAAGTCGCCACATTGCTTTTTCCTCTCTTTTTCGAAGACAGAGAATCTCCGAGA
GAGAGATTTCGGTAAAAACGCAATACCAGAAATTTATCATGCGCATATCGATTTGACCGCTTCTTTTTTTGTGTGTA
AGAAAGCTTATTATTACATTATTCATAATATTTATTTTTATTTTATGGATTTAATAAAATAGTTACGAGCATAAAAA
CTTTTATTTGGTCCTCAAATGTTCCTCCACTTTTTTTGTAGTACGAATATTCGTAAAAATGTATACAGAGTTAT
AGAGTTTAATATAAAATAATTCGCAATTAAAGAGCAATAATTGTAGTGCATTTCACCGCAGTGCATGTCAAACGTG
GACATTTGCAATGGGTGCCTGTGTGCCTGTGAGCAGGAAATCTCCGCGGCTTGTCCTGATTTTGGCCAAGACAAATA
AATCCGGCTGATAAATACAAGAAAAAGAAAAAAAGGAGGGGATCCGGCGGTCAGGGCCATGGACATTGAACTT
GAAAATGCTGAAAACGCTGGTAAAACATCCAACGAAACGAACGGCAAATGCTGTGTGTGTGTGTCTTTGGTTTGG
CTAAGGTTAGAGCAGTTGAGCAACAGGTTTTCATTGTGCCATTTGCCAATGGAAGATGGAAATCCAAACTGAAAA
AAAGAAAAATGTTCAGGCTGCCATAAGTGAAGAAAAAGGAAAACAAAACATGAAACACGGGCCGGCAATGTCA
TTCGGCATTTGGTTTTATTTTCCGCCCAAGTTGAAGTGATCCTGTGTGTAAATAATGTCTAATGTTGCCTGCCGGTT
GCATAATCGTGTGGCAATTATGCCAAAGAGATCCGTTTATTTTCTTTCTTTTTTCACATTTCGTTTTTTGGCCACTT
AGCGCGCTTGCCGCTTGCCACTTGCCACTTGATAATGTTGTTTTGTTTCTCGTGGAGCAAAAAAAACCCCAAACTC
GTTTCAATTATTGGGAAAAGCGGTATAAATATCATCGCTGCTAGCGCTGAAATCTTTGAAAACTGCGAAAACTGAAA
ACTGTAACCCAAAACAAACCAAAACCGAAACACAAACACCGCCGCATCCATCCCACACGACAAAAAATCAACGAA
AAAAACTGAAAAACGAGTCAATTCGATTTAAATTATAGGTTCAACGGCTGCTGGCGATCGCATCATTAAATGCGCT
TTTCAGTGGATACACGGGTGGCTTCGTTATGCAACATTTATACTACACACACAATTAATTAATAAAAACGTACTGG
TTATTTTAAGTGTGGCTTTTTATGGAGCTCCCGATCGCAATAAATTTAAGCAGCATTAGCCGTAATTATGTGCAACA
TATTTTTCGGTTGCCGCGTGTTTTTCTGTTTCTGTTTACTTTTCCGTGGGTGAGTCAAGATCTAGAATGCGGCCAAGG GATCAAGTTGAACCACTTTTTCGGCCACCATAATATTTTTACACATTTTGCATAAAATTAGCATCGCATAAATTGCG AAAACAAATGCTAAAAAATTACAAAAAATTAACAAAAATTGCGAAAAAAAATGTCAAATATATATATATATTTTTT AACATTTATTTTGAGTTCTAAAAAAAATAGCTTTAATAATATTTGACAAAATATTTTCCTTTAATATTTTTTTAGAAC ATTTATTTTGAGATCTAAAAAAAATAGTTGTAATAATTTTCGACTAAATATTTGCCCTTAATATTTTTTTGAGCCCCA ACTTTTCCTTACTCAACGTGTAGTTGTGTGATTCTAGATTAATGCAAACCACTTCATCAGCGGAGTCGTAAAAAC GTATCTTTACCTATTTGGCTTGTTCATTATGCGTGTGGTATTACTTTATTTTTTTTTTTGCAGACCAGGTGCAGTTG GGTAAAAATAGTTACATATGCGAACGCCTTCGGTGCGAATTTTTTTTCTGGATTTTCACATTCACTTGCGGCGATG GCCATTAGAGCATTACCCACTTAGGGCTCCCCTAAAAATCCAGGTGGTCCACAGGGACCACAAAAATATTGCAA TTACAGGCACTTGAGTGCTTCCTTAACTCTTTGAACACTTTACTTATGCAACTCTCAAATGTATGTACGAAATGAA ATGTATGCTAAAAATCACCTGCCCATAATTACGCGGAAACCAACTTTTTGACCCTCGGTGAATTGTGAATCATCGG AACTGCCCAACTGCCCAATCGAAATCAAAGCTAAACCAATCGAAACCAGCCCAAGTAATTCAAATTTAATGCTGTT CAAGAAATACCTGCTTTGTATACTCTATCTATACGATTTACTATAATGATAAATTATACTAATATCTGGCTTATTTG CATATATGTCATAAAATAGAAATAAGTGCACTGGTCATATAAATTGAACATATTTATCAACGGCTTTCAAAAAAT AATGAGAAATAATTAAATCTGACTTTCAAAAATTACAAATTAAATTACTGTTTTTTTTTTTAATAACTTTGAAAGTT GTTTATAGATAAAATATTTTTGAAGATGTCACACTGATATTAAGCTTAAAGCTTTAAAATATTTTGCAACAAAG AATTTACAAGTTTTTATTAAACGGAGCCGTTCCGTTTTTGGTGCGAAAGCCGAAAATTGCATTTTATGCACAAACC TGCCAGCCTAAAAGTGTGCTCAAAAATAGTATGAATACTAAATGAATGAATAACCCTGGTAAAAATAATGTCTA ACTTGAGTTCCATTATATTTATTAAATATACAGTACAGCAATATACATAACTTTTAGCTTTAAGAAATCAATGTTT GTAATGTCATCCAGCTTTAATGTATTTTGCAATAGAACAATGTAGTTAAGAAATTTATTTATGTTCATGAATCTGAC AAATTGTGACTAGCGCTTTAATTTATAAGTATTTTTGTACTTGTAGCGTTAGGAAGAAATAAAACCAAAATTAAA TTAAAAATATACAGCAACTTTATATTTTGTAATTAATTTACTCATAAATCAGCAAAATCTCAAATTCAGCTGAAGG CCAGGAATTTCAAAGAATTCAGCGTGCCAAAAACCAAAAAACCCTTTCAAAAGTGTATGAAAAATTGCGAATCCC AGCGAAAGGTGACTCGGCTGACTCGGTGAATTTTGAGGGTTCGAGATACTCGTATTTATTAAAACATGCGTGAAAA TCAATCACTGAATACAAAAGCCACGCACTAAAAAATAAATGCCCGAAGTTTAGACCACCACCGGCCGAACCACTG aAACCA

>P6

GAAATCTCCGCGGCTTGTCTGATTTTGGCCAAGACAAATAAATCCGGCTGATAAATACAAGAAAAAGAAAAAAA GGAGGGGATCCGGCGGTCAGGGCCATGGACATTGAACTTGAAAATGCTGAAAACGCTGGAAAACATCCAACGAA ACGAACGGCAAATGCTGTGTGTGTGTCTTTGGTTTTGGCTAAGGTTAGAGCAGTTGAGCAACAGGTTTCCATTT GCCATTTGCCAATGGAAGATGGAATCCAAACTGAAAAAAAGAAAAATGTTCAGGCTGCCATAAGTGAAGAAA AGGAAAACAAAACATGAAACACGGGCCGGGCAATGTCATTCGGCATTTGGTTTTTATTTTCCGCCCAAGTTGAAGTG ATCCTGTGTGTAAATAATGTCTAATGTTGCCTGCCGTTGCATAATCGTGTGGCAATTATGCCAAAGAGATCCGTTT ATTTTCTTTCTTTTTTTCACATTTTCGTTTTTTGGCCACTTAGCGCGCTTGCCGCTTGCCACTTGCCACTTGATAATGTT GTTTTGTTTCTCGTGGAGCAAAAAAAAACCCCAAACCTGTTTCAATTATTGGGAAAAGCGCGTATAAATCATCGCT GCTAGCGCTGAAATCTTTGAAAACTGCGAAAACTGAAAACTGTAACCCAAAACAAACCAAAACCGAAACACAAA CACCGCCGCATCCATCCCACACGACAAAAAATCAACGAAAAAAACTGAAAAACGAGTCAATTCGATTTAATTATA GGTTCAACGGCTGCTGGCGATCGCATCATAATTGCGCTTTTCAGTGGATACACGGGTGGCTTCGTTATGCAACATT TATACTACACACACAATTAATTAATAAAAACGTACTGGTTATTTTAAGTGTGGCTTTTTATGGAGCTCCCGATCGCA ATAATAATTAAGCAGCATTAGCGTAATTATGGTCAACATATTTTCGGTTGCCGCGTGTTTTTCTGTTTCTGTTTACT TTTCCGTGGGTGAGTCAAGATCTAGAATGCGGCCAAGGGATCAAGTTGAACCACTTTTTCGGCCACCATAATATTT TTACACATTTTGCATAAAATTAGCATCGCATAAATTGCGAAAACAAATGCTAAAAAATTACAAAAAATTAACAAAA ATTGCGAAAAAAAATGTCAAATATATATATATATTTTTTAACATTTATTTTGAGTTCTAAAAAAATAGCTTTAATAA TATTTGACAAAATATTTTCCTTTAATATTTTTTAGAACATTTATTTTGAGATCTAAAAAAATAGTTGAATAATTTT CGACTAAATATTTGCCCTTAATATTTTTTTGAGCCCAACTTTTCCTTACTCAACGTGTAGATTGTGTGATTCTAGAT TAATGCAAACCACTTCATCAGCGGAGGTCGTAAAACGTATCTTTACCTATTTGGCTTGTTCATTATGCGTGTGGTAT TACTTTATTTTTTTTTTTTCAGACCAGGTGCAGTTGGGTTAAAATAGTTACATATGCGAACGCCTTCGGTGCGAAT TTTTTTCTTGGATTTTCACATTCACTTGCGGCGATGGCCATTAGAGCATTACCCACTTAGGGCTCCCCTAAAAATC CAGGTGGTCCACAGGGACCACAAAAATATTGCAAATTACAGGCACTTGAGTGCTTCCTTAACTCTTTGAACACTTT ACTTATGCAACTCTCAAATTTGTATGTACGAAATGAAATGTATGCTAAAAATCACCTGCCCATAATTACGCGGAAAC CAACTTTTTGACCCTCGGTGAATTGTGAATCATCGGAACTGCCCAACTGCCCAATCGAAATCAAAGCTAAACCAAT CGAAACCAGCCCAAGTAATTCAAATTTAATGCTGTTCAAGAAATACCTGCTTTGTATACTCTATCTATACGATTTAC TATAATGATAAATTATACTAATATCTGGCTTATTTGCATATATGTCATAAAATAGAAATAAGTGCACTGGTCATAT AAATTGAACATATTTATCAACGGGCTTTCAAAAAAATAATGAGAAATAATTAAATCTGACTTTCAAAAATTACAAAT TAAATTACTGTTTTTTTTTTTAATAACTTTGAAAGTTGTTTATAGATAAAATATTTTTGAAGATGTCACACTGATATA TTAAGCTTAAAGCTTTAAAATATTTTGCAACAAAGAATTTTACAAGTTTTTATTAAACGGAGCCGTTCCGTTTTGG TGCGAAAGCCGAAAATTGCATTTTCCGCTTAAAGTGTGCTCAAAACCTGCCAGCCTAATGCAAACCTGCAAAAAATAGTATGAATACTA AATGAATGAATAACCCTGGTAAAAATAATGTCTAACTTGAGTTCCATTATATTTATTAAATATACAGTACAGCAA TATACATAACTTTTAGTCTTTAAGAAATCAATGTTTGTAATGTCATCCAGCTTTAATGTATTTTGCAATAGAACAAT GTAGTTAAGAAATTTATTTATGTTCATGAATCTGACAAATTGTGACTAGCGCTTTAATTTATAAGTATTTTTGTAC TTGTAGCGTTAGGAAGAAATAAAAACCAAAATTAAATTAAAAATATACAGCAACTTTATATTTTGTAATTAATTTAC
TCATAAATCAGCAAAATCTCAAATTCAGCTGAAGGCCAGGAATTTCAAAGAATTCAGCGTGCCAAAAACCAAAAA
ACCCTTTCAAAAGTGTATGAAAAATTGGCAATCCCAGCGAAAGGTGACTCGGCTGACTCGGTGAATTTTGAGGGTT
CGAGATACTCGTATTTTATTAAAACATGCGTGAAAATCAATCACTGAATACAAAAGCCACGCACTAAAAAATAAAT
GCCCGAAGTTTAGACCACCACCGGCCGAACCACTGaAACCA

>P7

TGCTAGCGCTGAAATCTTTGAAAACTGCGAAAACTGAAAACTGTAACCCAAAACAAACCAAAACCGAAACACAAA
CACCGCCGCATCCATCCCACACGACAAAAAATCAACGAAAAAAACTGAAAAAACGAGTCAATTCGATTTAAATTATA
GGTTCAACGGCTGCTGGCGATCGCATCATTAATTGCGCTTTTCAGTGGATACACGGGTGGCTTCGTTATGCAACATT
TATACTACACACACAATTAATTAATAAAAAACGTACTGGTTATTTAAGTGTGGCTTTTTATGGAGCTCCCGATCGCA
ATAAATTTAAGCAGCATTAGCCGTAATTATGTGCAACATATTTTCGGTTGCCGCGTGTTTTTCTGTTTCTGTTTACT
TTCCGTGGGTGAGTCAAGATCTAGAATGCGGCCAAGGGATCAAGTTGAACCACTTTTTCGGCCACCATAATATTT
TTACACATTTGCATAAAATTAGCATCGCATAAATTGCGAAACAAATGCTAAAAATTACAAAAAATTAACAAAA
ATTGCGAAAAAAAATGTCAAATATATATATATATTTTTAACATTTATTTTGAGTTCTAAAAAATAGCTTTAATAA
TATTTGACAAAATATTTTCCTTTAATATTTTTTAGAACATTTATTTTGAGATCTAAAAAATAGTTGAATAATTTT
CGACTAAATATTTGCCCTTAATATTTTTTTGAGCCCCAACTTTTCCTTACTCAACGTGTAGATTGTGTGATTCTAGAT
TAATGCAAACCACTTCATCAGCGGAGGTCGTAAAACGTATCTTTACCTATTTGGCTTGTTCATTATGCGTGTGGTAT
TACTTTATTTTTTTTTTTTCAGACCAGGTGCAGTTGGGTTAAAATAGTTACATATGCGAACGCCTTCGGTGCGAAT
TATTTTTCTTGGATTTTCACATTCACTTGCGGCGATGGCCATTAGAGCATTACCACTTAGGGCTCCCTAAAAATC
CAGGTGGTCCACAGGGACCACAAAAATATTGCAAATTACAGGCACTTGAGTGCTTCCTTAACTCTTTGAACACTTT
ACTTATGCAACTCTCAAATTTGTATGTACGAAATGAAATGTATGCTAAAAATCACCTGCCCATAATTACGCGGAAAC
CAACTTTTTGACCCTCGGTGAATTGTGAATCATCGGAACTGCCCAACTGCCCAATCGAAATCAAAGCTAAACCAAT
CGAAACCAGCCCAAGTAATTCAAATTTAATGCTGTTCAAGAAATACCTGCTTTGTATACTCTATCTATACGATTTAC
TATAATGATAAATTATACTAATATCTGGCTTATTTGCATATATGTCATAAAATAGAAATAAGTGCACTGGTCATAT
AAATTGAACATATTTATCAACGGCTTTCAAAAAATAATGAGAAATAATTAAATCTGACTTTCAAAAATTACAAAT
TAAATTACTGTTTTTTTTTTTAATACTTTGAAAGTTGTTATAGATAAAATATTTTTGAAGATGTCACACTGATATA
TTAAGCTTAAAGCTTTAAAATATTTTGCAACAAAGAATTTTACAAGTTTTTATTAAACGGAGCCGTTCGTTTTGG
TGCGAAAGCCGAAATTGCATTTTATGCACAAACCTGCCAGCCTAAAAGTGTGCTCAAAAATAGTATGAATACTA
AATGAATGAATAAACCTGGTAAAAATAATGTCTAACTTGAGTTCCATTATATTTTATTAAATATACAGTACAGCAA
TATACATACTTTTAGCTTTAAGAAATCAATGTTTGTAATGTCATCCAGCTTTAATGTATTTTGCAATAGAACAAT
GTAGTTAAGAAATTTATTTATGTTCATGAATCTGACAAATTGTGACTAGCGCTTTAATTTATAAGTATTTTTGTAC
TTGTAGCGTTAGGAAGAAATAAAACCAAAATTAAATTAAAAATATACAGCAACTTTATATTTTGAATTAATTTAC
TCATAAATCAGCAAAATCTCAAATTCAGCTGAAGGCCAGGAATTTCAAAGAATTCAGCGTGCCAAAAACCAAAAA
ACCCTTTCAAAAGTGTATGAAAAATTGGCAATCCCAGCGAAAGGTGACTCGGCTGACTCGGTGAATTTTGAGGGTT
CGAGATACTCGTATTTTATTAAAACATGCGTGAAAATCAATCACTGAATACAAAAGCCACGCACTAAAAAATAAAT
GCCCGAAGTTTAGACCACCACCGGCCGAACCACTGaAACCA

Chimeric constructs

BP-series (D. biarmipes + D. prostipennis)

>BP1

CAAGAGCCCAAGGTCGGTCGTTTAGCTTGGCCAAAAACCTACCCATCCAGCTGGCACTTCCACCAACGGCACCAAG
ACACGAGCGGAAATAAAAAGCCACACCACCCCACTTAGAACTCCGTTTAGCAGCAGTTGTTCAAACAGAAATTG
GCTGGCTTCGGCCGGTTCAGCTTCAGTTGATAATTATTATAATATCTATGTCTTGCCTATCGCTGGGCCCTAATTGG
CCCAGACAAAGGCACCGTTTTTATGCATAACTGGAGGCTTACAATTTGGCTTTCGACACGCGGTCCCTTCACATTGC
CAAAAAGAACGAGAACTCAGCAAGCCAATTACACTCGAAAAAGCAGCGGGATCGTTTCGATGCCTAGCCCTGGG
CTAGTTCAATCACTCCCGCCGATAATTGGCCGGCCTCTGCAATGGGAACTTTTCCAAGACGAGATCGATTCTTGGG
AAAACACCTCCTCAGTTTCCATTTCTGTTTTTTGGGTCCGGAAGTGGCATCGTGTCTTCCCAGAAGCGCCTCCAAAT
GGTGCCACCATTAGCCAGGGGGAAGCCGGGCGGCAGTCACTTAGCTGCTGCAATTTAAATACTTTTTAATTGATTA
CTAATTGCGGCGAGGCAAGTGCCAAAAACAAGACGACGAGGACGACTTGGCTGTGACGTTTTCGATGCAACCCGAC
CGGGGACTGCCACTCTTTAGCCAGTTAATTGGCAGCAAAAGCGACAGTGGCAGCGGCAGCAACTGCTTTTCACCA
GGAAATCAATAAACGATAGTCAAGCCAAGAGAAGAAAAACAAGCACAACACGCACATCTCAATTCAGTAGTAG
CAAAAAACAAAATAAAAATAGAGAGATAAAGATAAAGAAAAAGAAATAAAAAACCAACCCTGACCAACTCAATTTC
TCGTGCCAAAAATAAAAGCAAATATAGCCCAGTTTTTAATATGAAAATACAAACAATTCTAATTTGGCTGGAAAA
TACCCAGAAAAATAACACCTGAGTTCTAGTTCGATTTGTATAATGTTGGACTATAAAAGGCAGCCGTAACTTTCT
TCACTCACAAGTCCTCACAAGTATTGCAAACATGAAGCTGTTCCAACAAATAATCCTGGGTCTGGTGCTCATCTTC
GCCGTAATGAGTTCTCTGTCGACTGCTCAGCCCTTAAGGATGATGAATCCCTTATTGGGGACTCGGAATCGAATG
AAACTATACCCGATGACGTCCAACAGGATTATCTCAATGTGGCCAACTACGTGACTGATGCTCCTCCATGGTGGTG
GAACTAGACGTTTCAAAGGATTTAGAAAATGTTTTATTCTTTTTTTTGTGTGTGTTATTATTTTATTAAATTGATGT
ATTAAAATTACAATATACTAAACCCATTGAAACAAGAATATCATGTTGATAAATGGGGTGAAAATAAAATGAAAA
TTATTATAAAATTAATTAAATTATAAAATAACATTTTAAAAAATCCATATTTTGTATTGTTATTATTATGTTTTTT
TGCAACAAATATTTTATTTGCAATCACTTCAATTTCGGTTTTTAATATTTCGAAATCATCTTTTTCATAAACCCCAAA
AAACCAGTTTTTTTTTTTTTAACGATCAATTATCCTTAGTTCAGAAAGTATTAGCTTTTCATGCCGATTTTTTCCCGC
TTACCTATAAATACTTGTAAACGAAATTTATTTAAGCCAATAAACCAGATTTAGTAAGTGCTTCTTTATGAATATTT
TCCATTTAGTTATTTTAATTGAAAGCTACAAATTGTGGGTTTCAAATGTTGTGACTGCGGAACCGACGAACCACTAC
CAGTTAATGCAAATATATCATTCGCATTTACTTACACTTACACTTATCTTATTTTCTCGGACTGCCACGCCAACTA
ATGGAAATGTTTGCCTTGAAAtAgATCGGGGCGATtATTAATCGATTATCGCCCGATTACCACATTGAGTGGCTTAAA
GACCCATAAGAAATGCAACTCGTCAACTCGGCTGATGGCTTAAGATAAATAAGTCGCCGAGTCGCTCATAAATTC
GAATGCAGCCCGCTGATTTATGCACTCCAACTCAGCTGGATGGAAATACTATTACCATTAAGCGTTTTTCGACCA
CGGATTTTCCGCTTGCATGAGACAAGTCACCGCAATTGCAGGCAAATTATGTCTGAGGCAATGTTCGTGCTCGT
GTGTTTCGTGCAAGTTTACACAGAAATCAAATTACACGACAACCTCTACTCAATTCACAATTCACTACTTACTTGCT
TAGTTTACTTTTCGCGCAGTGAACAGACAATGCCTTTTATTGGCATCTTATTTGCGCCATTTAAGGATGCAATTTTC
TGAGCTAAAACACATTTAAGGAGAGATCTAAATTTCTCTTGTTTTGGCTTGAATAAATTTAACGAATCCTTGTCGA
CTATTTAAATACACATAAGGTGGGGGCTCTCGCATATCTTGTGTTTTAATTTAAATACAATATTGGTTAAGACATTT
GTAATTAGCCAAAAACTCACTAAAGGAGCGATCTAAATTTCTCTTTTTTTGGCTTGAATAAATTAAGGACATTCCA
AGTTGAGTATTTAAATTACACAAAAGGAGCTGCTTTGAAATCTTGTCTTTTTCTTTGTCTAGTTAAATAGAATATT
GGTAAGTAATGTTGTAATGTTATGTGGTATTAATTTTGACATGATACGCGGTTATCTCAGTTCGATATGCTCGAAAT
GTAAATAACAGCCCAAGTTCTAATTTCGAATGTGTCTTTCTCACTCCCACTCGCGTAATTTAAGTCGCCACATTGCTT
TTTCCTCTCTTTTTCGAAGACAGAGAATCTCCGAGAGAGAGATTTCGGTAAAAACGCAATACCAGAAATTTATCAT
GCGCATATCGATTTGACCGCTTCTTTTTTTGTGTGTAAGAAAGCTTATTATTACATTATTCATAATATTTATTTTAT
TTTATGGATTTAATAAAATAGTTACGAGCATAAAAAACTTTTATTTGGTCCTCAAATGTTCCTCCACTTTTTTTGTA
GTACGAATATTTCGTAAAAATGTATACAGAGTTTATAGAGTTTAATATAAAATAATTCGAATTAAGAGCACTAA
TTGTAGTCATTTCACCGCAGTGCATGTCAAACGTGGACATTTGCAATGGGTGCCTGTGTGCCTGTGAGCAGGAAA
TCTCCGCGGCTTGTCTGATTTTGGCCAAGACAAATAAATCCGGCTGATAAATACAAGAAAAAGAAAAAAAAGGAG
GGGATCCGGCGGTCAGGGCCATGGACATTGAACTTGAAAATGCTGAAAACGCTGGTAAAACATCCAACGAAACGA
ACGGCAAATGCTGTGTGTGTGTGTGTGTTCTTTGGGTTTGGCTAAGGTTAGCAGGTTGAGCAACAGGTTTCCATTTGCCAT
TTGCCAATGGAAGATGGAAATCCAAACTGAAAAAAAGAAAAATGTTCAGGCTGCCATAAGTGAAGAAAAGGAA
AACAAAACATGAAACACGGGCCGGGCAATGTCATTCGGCATTGGGTTTATTTTCCGCCCAAGTTGAAGTGATCCT
GTGTGTAATAATGTCTAATGTTGCCTGCCGGTTGCATAATCGTGTGGCAATTATGCCAAAGAGATCCGTTTATTTT
CTTTCTTTTTTTCACATTTCGTGTGTTGTTTGGCCACTTAGCGCGCTTGCCGCTTGCCACTTGCCACTTGATAATGTTGTTTT
GTTTCTCGTGGAGCAAAAAAAAACCCCAAACTCGTTTCAATTATTGGGAAAAGCGCGTATAAATCATCGCTGCTAG
CGCTGAAATCTTTGAAAACTGCGAAAACTGAAAACTGTAACCCAAAACAAACCAAAACCGAAACACAAACACCG
CCGCATCCATCCCACACGACAAAAATCAACGAAAAAAACTGAAAAACGAGTCAATTCGATTTAAATTATAGGTTC
AACGGCTGCTGGCGATCGCATCATAATTGCGCTTTTCAGTGGATACACGGGTGGCTTCGTTATGCAACATTTATAC
TACACACACAATTAATTAATAAAACGTACTGGTTATTTTAAGTGTGGCTTTTATGGAGCTCCCGATCGCAATAA
ATTTAAGCAGCATTAGCCGTAAATTATGTGCAACATATTTTCGGTTGCCGCGTGTTTTTCTGTTTCTGTTTACTTTTC
CGTGGGTGAGTCAAGATCTAGAATGCGCCAAGGGATCAAGTTGAACCACTTTTTCGGCCACCATAATATTTTAC
ACATTTGCATAAAATTAGCATCGCATAAATTGCGAAAACAAATGCTAAAAATTACAAAAAATTAACAAAAATTG
CGAAAAAAAATGTCAAAATATATATATATATATTTTTAACATTTATTTTGAGTTCTAAAAAATAGCTTTAATAATATT
TGACAAAATATTTTCCTTTAATATTTTTTTAGAACATTTATTTTGAGATCTAAAAAATAGTTGTAATAATTTTCGA
CTAAATATTTGCCCTTAATATTTTTTTGAGCCCCAACTTTTCCTTACTCAACGTGTAGATTGTGTGATTCTAGATTAA
TGCAAACCACTTCATCAGCGGAGGTCGTAAAACGTATCTTTACCTATTTGGCTTGTCATTATGCGTGTGGTATTAC
TTTATTTTTTTTTTTGCAGACCAGGTGCAGTTGGGTTAAAATAGTTACATATGCGAACGCCTTCGGTGCGAATTTT
TTTTCTTGGATTTTCACATTCACGCGCGATGGCCATTAGAGCATTACCCACTTAGGGCTCCCTAAAACCAAG
GTGGTCCACAGGGACCACAAAAAATATTGCAAATTACAGGCACTTGAGTGCTTCCTTAACTCTTTGAACACTTTACT
TATGCAACTCTCAAATGTATGTACGAAATGAAATGTATGCTAAAAATCACCTGCCCATAATTACGCGGAAACCAA
CTTTTTGACCCTCGGTGAATTGTGAATCATCGGAACTGCCCAACTGCCCAATCGAAATCAAAGCTAAACCAATCGA
AACCAGCCCAAGTAATTCAAATTTAATGCTGTTCAAGAAATACCTGCTTTGTATACTCTATCTATACGATTTACTAT
AATGATAAATTATACTAATATCTGGCTTATTTGCATATATGTCATAAAATAGAAATAAGTGCACTGGTCATATAAA
TTGAACATATTTATCAACGGGCTTTCAAAAAATAATGAGAAATAATTTAATCTGACTTTCAAAAATTACAAATTAA
ATTACTGTTTTTTTTTTTAATAACTTTGAAAGTTGTTTATAGATAAAATATTTTTGAAGATGTCACACTGATATTA
AGCTTTAAGCTTTTAAAATATTTTGCAACAAAGAATTTTACAAGTTTTTATTAAACGGAGCCGTTCCGTTTTTGGTC
GAAAGCCGAAAATTGCATTTTATGCACAAACCTGCCAGCCTAAAAGTGTGCTCAAAAATAGTATGAATACTAAAT
GAATGAATAAACCTGGTAAAAATAATGTCTAACTTGAGTTCCATTATATTTATTAAATATACAGTACAGCAATAT
ACATACTTTTAGCTTTAAGAAATCAATGTTTGTAAATGTCATCCAGCTTTAATGTATTTTGCAATAGAACAATGTA
GTTAAGAAATTTATTTATGTCATGAATCTGACAAATTGTGACTAGCGCTTTAATTTATAAGTATTTTTGTACTTGT
AGCGTTAGGAAGAAATAAAACCAAAATTAAATTAAAAATATACAGCAACTTTATATTTGTATAATTAATTTACTCAT
AAATCAGCAAAATCTCAAATTCAGCTGAAGGCCAGGAATTTCAAAGAATTCAGCGTGCCAAAAACCAAAAAACCC
TTTCAAAAGTGTATGAAAAATTGGCAATCCCAGCGAAAGGTGACTCGGCTGACTCGGTGAATTTTGAGGGTTCGAG
ATACTCGTATTTATTAAAAACATGCGTGAAAATCAATCACTGAATACAAAAGCCACGCACTAAAAAATAAATGCCC
GAAGTTTAGACCACCACCGGCCGAACCACTGGAACCAG

>BP2

CAAGAGCCCAAGGTCGGTCGTTTAGCTTGGCCAAAACCTACCCATCCAGCTGGCACTTCCACCAACGGCACCAAG
ACACGAGCGGAAAATAAAAAAGCCACACCACCCCACTTAGAACTCCGTTTAGCAGCAGTTGTTCAAACAGAAATTG
GCTGGCTTCGGCCGGTTCAGCTTCAGTTGATAAATTATTATAAATATCTATGTTCTTGCCTATCGCTGGGCCCTAATTGG
CCCAGACAAAGGCACCGTTTTTATGCATAACTGGAGGCTTACAATTTGGCTTTCGACACGCGGTCCTTCACATTGC
CAAAAAGAACGAGAACTCAGCAAGCCAATTACACTCGAAAAAGCAGCGGGGATCGTTTCGATGCCTAGCCCTGGG
CTAGTTCAATCACTCCCGCCGATAATTGGCCGGCCTCTGCAATGGGAACTTTTCCAAGACGAGATCGATTCTTGGG
AAAACACCTCCTCAGTTTCCATTTCTGTTTTTGGGTCCGGAAGTGGCATCGTGTCTTCCCAGAAGCGCCTCCAAAT
GGTGCCACCATTCAGCCAGGGGCGACGGCAGTCACTTAGCTGCTGCAATTAAATACTTTTTAATTGATTA
CTAATTGCGGCGAGGCAAGTGCCAAAACAAGACGACGAGGACGACTTGGCTGTGACGTTTCGATGCAACCCGAC
CGGGGACTGCCACTCTTTAGCCAGTTAATTGGCAGCAAAAGCGACAGTGGCAGCGGCAGCAACTGCTTTTCACCA
GGAAATCAATAAACGCTCGTCCAGCGGCAAAAGTAATCGCAACACGCACATCTCAATTTCGGTGGCAGAAAAAAA
ACCCTCACCAGCTCAATTCCCGTGCCAAATTAACCAGAGCAAACATAGCCCAGTTTCTTCTCCTGCGGCATGTGA
AAAGGCAAACAGTGCTGGCCGGAAATACCCAGCAAAACACCTGAGTTCTAGTTGCGATTTTCGGAATTGGACTA
TAAAAGGCGGCCGTCGGGTAGCTTTCTCACTCACAACCAGTCCAAAAGCATCTCCAACATGAAGTTCTTCCAGCA
AATCGTCCTGGGTCTGGTCTCGTCCTGGCCATCATGGGTCGCTGGCCAGCGCCAAGCCCCAGGAGGCCGAGGA
ACCGGAGGAGTCGCTGGTCGGGGACTCAGAGTCGGGACAGTCCGTGCCCGAGGACGCCCAGCAGGACTACCTCAA
CGTGGCGGACTTCACCACTGCCGCTCCTACATGGTGGTGGAACTAGAGCCCGGGAATTCTAGAGGATTTTAACAAT
CTTTTGTTTTTTTTTGCTAATCTAATGTACTATAATTGCAAAGAATTTATGGTGTCCATATTCAATAAACCTATTTA
AAGCTGAATATAATGTAAACCGTATATAAATGTTCTTGTATGATACATTTTACTAAATTAAAAGTTAAATAATTA
AAATATTTAATTTACTCATTGTGGGAGTTCATTAGACTTATTGTTTGTTTTTATTAAATTGTAATTTGTATCAAAAGT
TTAAGTTAAAGTCTTAAAAATATATCAAGTTCATTGCACAAATTAACTTAAAAATATGTACCAAAAAATGTAGAAA
TCAACCTATTTAATCTAAATGTAAATAAATGTAACAAACCAATCATGTCTTAAATTAAATATGTTTTTAAGCCTAAC
ACTTATATTTAAAAAATAATTATAATTCAGACTTAAATTTTAAAATCGTCTCACCTTTTTTTAGTTTATTTGATGCAT
GTTTTAATTTTGCTAAAATCGTATTTTGATGTCTATTCATTTTGCCAGCCAGTAATCTAAAAAGTCGACCTATCACT
CTCCCCCTCTTATATTTCGACCTATAAATACCCACCGCAAATGCCGCAACCAACCTAACCCACAGAGGCCAGTTCGG
GTTGTTTAATGGACAATTATCCTTAGTTCAGAAAGTATTAGCTTTTCATGCCGATTTTTTCCCGCTTACCTATAAATA
CTTGT AACGAAATTTATTTAAGCCAATAAACCAGATTTAGTAAGTGCTCTTTATGAATATTTCCATTTAGTTAT
TTTAATTGAAAGCTACAAATTGTGGTTTCAAATGTTGTGACTGCGGAACCGACGAACCACTACCAGTTAATGCAA
AATATATTCGTCGATTTACTTATCTTATTTCTCGACTGCCACGCCAAATATGGAAATGTTT
GCCTTGAA tAgATCGGGGCGAT tTAATATCGATTATCGCCCGATTACCACATTGAGTGGCTTAAAGACCCATAAGAA
ATGCAACTCGTCAACTCGGCTGATGGCTTAAGATAAATAAAGTCGCCGAGTCGCTCATAAATTTCGAATGCAGCCCG
CTGATTTATGCACTCCAACTTCAGCTGGATGGAAATACTATTACCATTAAGCGTTTTTCGACCACGGATTTTCCGC
TTGCATGAGACAAGTGCACCGCAATTGCAGGCAAATTATGTCTGAGGCAATGTTCGTGCTCGTGTGTTTCGTGCAA
GTTTACACAGAAATCAAATTACACGACAACCTCTACTCAATTCACAATTCACTACTTACTTGCTTAGTTTACTTTTC
GCGCAGTGAACAGACAATGCCTTTTATTGGCATCTTATTTGCGCCATTTAAGGATGCAATTTTCTGAGCTAAAACA
CATTTAAGGAGAGATCTAAATTTCTCTTGTTTTGGCTTGAATAAATTTAACGAATTCCTTGTCGACTATTTAAATAC
ACATAAGGTGGGGGCTCTCGCATATCTTGTGTTTTAATTTAAATACAATATTGGTTAAGACATTTGTAATTAGCCAA
AAACTCACTAAAGGAGCGATCTAAATTTCTCTTTTTTGGCTTGAATAAATTAAAGGACATTCCAAGTTGAGTATTTA
AATTACACAAAAGGAGCTGCTTTGAAATCTTGTCTTTTTTCTCTTTGTCTAGTTAAATAGAATATTGGTAAGTAATGTT
GTAATGTTATGTGGTATTAATTTTGACATGATACGCGGTTATCTCAGTTCGATATGCTCGAAATGTAAATAACAGCC
CAGTTCTAATTTCGAATGTGTCTTTCTCACTCCCACTCGCGTAATTTAAGTCGCCACATTGCTTTTTCCTCTCTTTTTC
GAAGACAGAGAATCTCCGAGAGAGAGATTCGGTAAAAACGCAATACCAGAAATTTATCATGCGCATATCGATTT
GACCGCTCTTTTTTTGTGTGTAAGAAAGTCTTATTACATTATTTAATTTTATTTTTATTGATGATTTT
AAAATAGTTACGAGCATAAAAAACTTTTATTTTGGTCCTCAAATGTTCCTCCACTTTTTTTGTAGTACGAATATTTC
GTAAAAATGTATACAGAGTTTATAGAGTTTAATATAAAATAATTCGCAATTAAAGAGCACTAATTGTAGTGCATTT
CACCGCAGTGCATGTCAAACGTGGACATTTGCAATGGGTGCCTGTGTGCCTGTGAGCAGGAAATCTCCGCGGCTTG
TCTGATTTTTGCCCAAGACAAATAAATCCGCTGATAAATACAAGAAAAAGAAAAAAAGGAGGGGATCCGGCGG
TCAGGGCCATGGACATTGAACTTGAAAATGCTGAAAACGCTGGTAAAAACATCCAACGAAACGAACGGCAAATGCT
GTGTGTGTGTCTTTGGTTTTGGCTAAGGTTAGAGCAGTTGAGCAACAGGTTTCCATTTGCCATTTGCCAATGGAA
GATGGAAATCCAAACTGAAAAAAAGAAAAATGTTCAGGCTGCCATAAGTGAAGAAAAGGAAAACAAAAACATGA
AACACGGGCCGGGCAATGTCATTCGGCATTTGGTTTTATTTCCGCCAAGTTGAAGTGATCCTGTGTGTAATAAT
GTCTAATGTTGCCTGCCGGTTGCATAATCGTGTGGCAATTATGCCAAAGAGATCCGTTTATTTCTTTCTTTTTTCA
CATTTCGTTTTTTGGCCACTTAGCGCGCTTGCCGCTTGCCACTTGCCACTTGATAATGTTGTTTTGTTTCTCGTGGAG
CAAAAAAAACCCCAAACTCGTTTCAATTATTGGGAAAAGCGCGTATAAATCATCGCTGCTAGCGCTGAAATCTTT
GAAAACTGCGAAAACTGAAAACTGTAACCCAAAACAAACCAAAACCGAAACACAAACACCGCCGCATCCATCCC
ACACGACAAAAAATCAACGAAAAAAACTGAAAAACGAGTCAATTCGATTTAAATTATAGGTTCAACGGCTGCTGGC
GATCGCATCATAATTGCGCTTTTCAGTGGATACACGGGTGGCTTCGTTATGCAACATTTATACTACACACACAATT
AATTAATAAAACGTACTGGTTATTTTAAGTGTGGCTTTTATGGAGCTCCCGATCGCAATAAATTTAAGCAGCATT
AGCCGTAATTATGTGCAACATATTTTTCGGTTGCCGCGTGTTTTTCTGTTTCTGTTTACTTTTCCGTGGGTGAGTCAA
GATCTAGAATGCGGCCAAGGATGTAACCACTTTTTCGGCCACCAATATTTTACACATTTTGCATAAA
ATTAGCATCGCATAAATTGCGAAAACAAATGCTAAAAATTACAAAAAATTAACAAAAAATTGCGAAAAAAAAATGT
CAAAATATATATATATATTTTTTAACATTTATTTTGAGTTCTAAAAAAATAGCTTTAATAATATTTGACAAAATATTTT
CCTTTAATATTTTTTTAGAACATTTATTTTGAGATCTAAAAAAATAGTTGTAATAATTTTCGACTAAATATTTGCCCT
TAATATTTTTTTGAGCCCAACTTTTCCTTACTCAACGTGTAGATTGTGTGATTCTAGATTAATGCAAACCACTTCAT
CAGCGGAGGTCGTAAAAACGTATCTTTACCTATTTGGCTTGTTCATTATGCGTGTGGTATTACTTTATTTTTTTTTTTT
GCAGACCAGGTGCAGTTGGGTTAAAATAGTTACATATGCGAACGCCTTCGGTGGCGAATTTTTTTTCTTGGATTTTCA
CATCACTTGCGGCGATGGCCATTAGAGCATTACCCACTTAGGGCTCCCCTAAAAAATCCAGGTGGTCCACAGGGAC
CACAAAAAATATTGCAAATTACAGGCACTTGAGTGCTTCCTTAACTCTTTGAACACTTTACTTATGCAACTCTCAAAT
TGTATGTACGAAATGAAATGTATGCTAAAAAATCACCTGCCCATAATTACGCGGAAACCACTTTTTGACCCTCGGT
GAATTGTGAATCATCGGAACTGCCAACTGCCCCAATCGAAATCAAAGCTAAACCAATCGAAACCAGCCCAAGTAA
TTCAAATTTAATGCTGTTCAAGAAATACCTGCTTTGTATACTCTATCTATACGATTTACTATAATGATAAATTATAC
TAATATCTGGCTTATTTGCATATATGTCATAAAATAGAAATAAGTGCACTGGTCATATAAATTGAACATATTTATCA
ACGGGCTTTCAAAAAATAATGAGAAATAATTAAATCTGACTTTCAAAAATTACAAATTAAATTACTGTTTTTTTTTT
TAATACTTTGAAAGTTGTTTATAGATAAAATATTTTTGAAGATGTCACACTGATATATTAGCTTAAAGCTTTAAA
ATATTTTGCAACAAAGAATTTACAAGTTTTTATTAAACGGAGCCGTTCCGTTTTTGGTGCGAAAGCCGAAAATTG
CATTTTATGCACAAACCTGCCAGCCTAAAAGTGTGCTCAAAAATAGTATGAATACTAAATGAATGAATAACCCTG
GTAAAAATAATGTCTAACTTGAGTTCCATTATATTTATTAAATATACAGTACAGCAATATACATAACTTTTAGCTTT
TAAGAAATCAATGTTTGAATGTCATCCAGCTTTAATGTATTTTGCAATAGAACAATGTAGTTAAGAAATTTATTTA
TGTTCATGAATCTGACAAATTGTGACTAGCGCTTTAATTTATAAGTATTTTTTGACTTGTAGCGTTAGGAAGAAAT
AAAACCAAAATTAAATTAAAAATATACAGCAACTTTATATTTTGAATTAATTTACTCATAAATCAGCAAAATCTC
AAATTCAGCTGAAGGCCAGGAATTTCAAAGAATTCAGCGTGCCAAAAACCAAAAAACCCTTTCAAAAGTGTATGA
AAAATTGGCAATCCCAGCGAAAGGTGACTCGGCTGACTCGGTGAATTTTGAGGGTTCGAGATACTCGTATTTATTA
AAACATGCGTGAAAAATCAATCACTGAATACAAAAGCCACGCACTAAAAAATAAATGCCCGAAGTTTAGACCACCA
CCGGCCGAACCACTGGAACCAG

>BP3

CAAGAGCCCAAGGTCGGTCGTTTAGCTTGGCCAAAACCTACCCATCCAGCTGGCACTTCCACCAACGGCACCAAG
ACACGAGCGGAAAATAAAAAGCCACACCACCCCACTTAGAACTCCGTTTAGCAGCAGTTGTTCAAACAGAAATTG
GCTGGCTTCGGCCGGTTCAGCTTCAGTTGATAATTATTATAATATCTATGTTCTTGCCTATCGCTGGGCCCTAATTGG
CCCAGACAAAGGCACCGTTTTTATGCATAACTGGAGGCTTACAATTTGGCTTTCGACACGCGGTCCTTCACATTGC
CAAAAAGAACGAGAACTCAGCAAGCCAATTACACTCGAAAAAGCAGCGGGGATCGTTTCGATGCCTAGCCCTGGG
CTAGTTCAAATCACTCCCGGATAATGGGACCGCTCTGCAATGGGACCGTATGGGACAGATCGATCTTGGG
AAAACACCTCCTCAGTTTCCATTTCTGTTTTTTGGGTCCGGAAGTGGCATCGTGTCTTCCAGAAGCGCCTCCAAAT
GGTGCCACCATTAGCCAGGGGAAGCCGGGCGGCAGTCACTTAGCTGCTGCAATTTAAATACTTTTTAATTGATTA
CTAATTGCGGCGAGGCAAGTGCCAAAACAAGACGACGAGGACGACTTGGCTGTGACGTTTTCGATGCAACCCGAC
CGGGGACTGCCACTCTTTAGCCAGTTAATTGGCAGCAAAAGCGACAGTGGCAGCGGCAGCAACTGCTTTTCACCA
GGAAATCAATAAACGCTCGTCCAGCGGCAAAAGTAATCGCAACACGCACATCTCAATTTCGGTGGCAGAAAAAAA
ACCCTCACCAGCTCAATTCCCCGTGCCAAATTAACCAGAGCAAACATAGCCCAGTTTCTTCTCCTGCGGCATGTGA
AAAGGCAAACAGTGCTGGCCGGAAAATACCAGCAAAACACCTGAGTTCTAGTTGCGATTTTCGGAATTGGACTA
TAAAAGGCGGCCGTCGGGTAGCTTTCTTCACTCACAACCAGTCCAAAAGCATCTCCAACATGAAGTTCTCCAGCA
AATCGTCCTGGGTCTGGTGCTCGTCCTGGCCATCATGGGTTCGCTGGCCAGCGCCAAGCCCCAGGAGGCCGAGGA
ACCGGAGGAGTCGCTGGTCGGGGACTCAGAGTCGGGACAGTCCGTGCCCCGAGGACGCCCAGCAGGACTACCTCAA
CGTGGCGGACTTCACCACTGCCGCTCCTACATGGTGGTGAACTAGAGCCCGGGAATTCTAGAGGATTTTAACAAT
CTTTTGTTTTTTTTTTGCTAATCTAATGTACTATAATTGCAAAGAATTTATGGTGTCCATATTCAATAAACCTATTTA
AAGCTGAATAATATGTAAACCGTATATAATGTTCTTGTTATGATACATTTTACTAAATTAAAAGTTAAATAATTA
AAATATTTAATTTACTCATTGTGGGAGTTCATTAGACTTATTGTTTGTTTTTATTAAATTGTAATTTGTATCAAAAGT
TTAAGTTAAAGTCTTAAAAATATATATCAAGTTCATTGCACAAATTAACTTAAAAATATGTACCAAAAATGTAGAAA
TCAACCTATTTAATCTAAATGTAAATAAATGTAACAAACCAATCATGTCTTAAATTAAATATGTTTTTAAGCCTAAC
ACTTATATTTAAAAAATAATTATAATTCAGACTTAAATTTTAAAAATCGTCTCACCTTTTTTAGTTTATTGATGCAT
GTTTTAATTTTGCTAAAAATCGTATTTTGATGTCTATTCATTTTGCCAGCCAGTAATCTAAAAAGTCGACCTATCACT
CTCCCCCTCTTATATTCGACCTATAAATACCCACCGCAAATGCCGCAACCAACCTAACCCACAGAGCCAGTTCGG
GTTGTTTAATGGACAATTATCCTTAGTTCAGAAaGCGCCTGCCTTTATGCGTATTTCCCCGCTTGCCTGCGAATACG
CCTAACGAAATTTACTCGAGCCCGTAAACCCAGTTTCGGTAAGTGCTTCTTTATGAATATTTCCATTTACTTTAAT
TGAAAGCTGCCAATTGTGGTGCCCGAGTGTTGTGACTGCTGGCCAATGAGGCGGTAATACGTTAAGTCGGAGCTGC
GGAACGGGATGATGGACCAGTTGAGGCGAAGTACATCAATCTCATTTGCCCGCACTTATCGAACGGTTGCCTTGGG
GAGATCGCTGCGATTGCTTATCGATAATCGCCCGATTACCGCGCTGAGCGGTCTTAAAGACCCATAAGAAATGCGG
CGATGGCGGCTTTAGATAAGTAAGTCGTCGGGGCGCTCATAAATTTCGAGCGCGATCCACGGATTTATGCACTCGC
TGGAAAAGCTATTACCATTAGGCTTTTCGCGACCACGGATTTTCCGCTTGCCTGAGACAAGTGGCGGCGGCAGT
TGCAGGCAAATTATGTGTGAGGCAATGCCGCGGGCATGTCTACACCGAAATCAAATTACGGCAACCTCTATTCACT
TATTTGCTTAGTTTTTTGCGCAGTGAGCGGCCAGCGCCTTGTATTGGCATCTAATTATCCGTTTAAGGACGCAATT
TTCTGAGCTAAAACTCGCTTATGGAGAGATCTAAATTTCCCCGCTTTTGGCTTGAATAAATTTAACGAATTCCTTGT
CGACTATTAAATACACATAAGGTGGGGGCTCGCATATCTTGTGTTTTAATTAAATACAATATTGGTTAAGACA
TTTGTAAATTAGCCAAAAACTCACTAAAGGAGCGATCTAAATTTCTCTTTTTTTGGCTTGAATAAATTAAGGACATTC
CAAGTTGAGTATTTAAATTACACAAAAGGAGCTGCTTTGAAATCTTGTCTTTTTTCTTTGTCTAGTTAAATAGAATA
TTGGTAAGTAATGTTGTAATGTTATGTGGTATTAATTTTGACATGATACGCGGTTATCTCAGTTCGATATGCTCGAA
ATGTAAATAACAGCCCAGTTCTAATTTCGAATGTGTCTTTCTCACTCCCACTCGCGTAATTTAAGTCGCCACATTGC
CTTTTGTTTTTTTTTGCTAATCTAATGTACTATAATTGCAAAGAATTTATGGTGTTCCATATTCAATAAACCTATTTA AAGCTGAATATAATGTAAACCGTATATAAATGTTCTTGTATGATACATTTTACTAAATTAAAAGTTAAATAATTA AAATATTTAATTTACTCATTGTGGGAGTTCATTAGACTTATTGTTTGTTTTTATTAAATTGTAATTTGTATCAAAAGT TTAAGTTAAAGTCTTAAAAATATATATCAAGTTCATTGCACAAATTAACTTAAAAATATGTACCAAAAATGTAGAAA TCAACCTATTTAATCTAAATGTAAATAAATGTAACAAACCAATCATGTCTTAAATTAAATATGTTTTTAAGCCTAAC ACTTATATTTAAAAAATAATTATAATTCAGACTTAAATTTTAAAAATCGTCTCACCTTTTTTAGTTTATTTGATGCAT GTTTTAATTTTGCTAAAATCGTATTTTGATGTCTATTCATTTGCCAGCCAGTAATCTAAAAAGTCGACCTATCACT CTCCCCCTCTTATATTTCGACCTATAAATACCCACCGCAAATGCCGCAACCAACCTAACCCACAGAGCCAGTTCGG GTTGTTTAATGGACAATTATCCTTAGTTCAGAAaGCGCCTGCCTTTATGCGTATTTCCCCGCTTGCCTGCGAATACG CCTAACGAAATTTACTCGAGCCCGTAAACCCAGTTTCGGTAAGTGCTTCTTTATGAATATTTCCATTTACTTTAAT TGAAAGCTGCCAATTGTGGTGCCCGAGTGTTGTGACTGCTGGCCAATGAGGCGGTAATACGTTAAGTCGGAGCTGC GGAACGGGATGATGGACCAGTTGAGGCGAAGTACATCAATCTCATTTGCCCGCACTTATCGAACGGTTGCCTTGGG GAGATCGCTGCGATTGCTTATCGATAATCGCCCGATTACCGCGCTGAGCGGTCTTAAAGACCCATAAGAAATGCGG CGATGGCGGCTTTAGATAAGTAAGTCGTCGGGGCGCTCATAAATTTCGAGCGCGATCCACGGATTTATGCACTCGC TGGAAAGCTATTACCATTAGGCTTTTCGCGACCACGGATTTTCCGCTTGCCTGAGACAAGTGCGGCGCGCAGT TGCAGGCAAATTATGTGTGAGGCAATGCCGCGGGCATGTCTACACCGAAATCAAATTACGGCAACCTCTATTCACT TATTTGCTTAGTTTTTTGCGCAGTGAGCGGCCAGCGCCTTGTATTGGCATCTAATTATCCGTTTAAGGACGCAATT TTCTGAGCTAAAACTCGCTTATGGAGAGATCTAAATTTCCCCGCTTTTGGCTTGAATAAATTAATCGAATTCCCCGC TGGCTATTAAAACACACAAAAAGGCGCTCTCGTCTGTTTCAATGTAAATTGCAAATTGCTCAATCCGCCTAATTGAT GTGCGCCCATGCAATAGTTTTGTGCCAATCATTTTTAGTACACCCCTAACTGGTGTTTTCTACGCATAATATGTGCC ATGGCTTAGGGCCTTTTGGTGACTTACCAACTGAAGAAGACGATTGTGGGGGTGCGTTTGGCGCAGTGCACGCCT GCGAGCAGGAAATCTCTTTCTCGGCCTGTCTGATTTTGGCCAAGACAAATAAATCCGGCTGGCAGATAGGCAGAG GGGACCCGCGCGGTCAGGCCGTGGACATTGAACTTGAAAACGCAGCCAGCGCCGAAAAACATTGTATTCACAACGAC GGCAAGTGCTGCGCGGCATGGGTGTCTCTGGCTAAGGTTACGGCGGTTGGGCAACAGGTTTCCCCCGGCCAACAC TGGGAGGAGAAAATAAAAAGGAAAATGTTCAGGCTGCCATAAGTGGGGAAAAAGGAAAACAAAAACATGAAACAC GGGCCGGGCAATGTCACTCGGCATTCGCTTGATTTTCCGCCTAACTCGCAGCGGTCCTGTGTGTAAATAATGTCTA ATGTTGCATGCCGGTTGCATAATCGTGTGGCAATTATGCCAGAGAGATTCGCTTATTTATTTTTACTTTCTGCCAT GTTCGCCCTGCCACCGTATTTCTTTTCGCCACTTAGTGCGCTCCGCTTGATAATGATGTTTTGTTTTTCGCCGGACA AACTCGTTTCAATTATTGGGAAAAGCGCGTATAAATCATCGCTGCTAGCGCTGAAATCTTTGAAAACTGCGAAAAC TGAAAACTGTAACCCAAAACAAACCAAAACCGAAACACAAACACCGCCGCATCCCATCCACACGACAAAAATCA ACGAAAAAAACTGAAAAACGAGTCAATTTCGATTTAAATTATAGGTTCAACGGCTGCTGGCGATCGCATCATTAAIT GCGCTTTTCAGTGGATACACGGGTGGCTTCGTTATGCAACATTTATACTACACACACAATTAATATAAAAAACGT ACTGGTTATTTTAAGTGTGGCTTTTTATGGAGCTCCCGATCGCAATAAATTTAAGCAGCATTAGCCGTAATTATGTG CAACATATTTTTCGTTGCCGCGTGTTTTTCTGTTTCTGTTTACTTTCCGTGGGTGAGTCAAGATCTAGAATGCGGC CAAGGGATCAAGTTGAACCACTTTTTCGGCCACCATAATATTTTACACATTTTGCATAAAATTAGCATCGCATAA ATTGCGAAAACAAATGCTAAAAAATTACAAAAAATTAACAAAAATTGCGAAAAAAAAAATGTCAAAATATATATATAA TTTTTTAACATTTATTTTGAGTTCTAAAAAAATAGCTTTAATAATATTTGACAAAATATTTTCCTTTAATATTTTTTT AGAACATTTATTTTGAGATCTAAAAAAATAGTTGTAATAATTTTCGACTAAATATTTGCCCTTAATATTTTTTGAG CCCCAACTTTTCCTTACTCAACGTGTAGATTGTGTGATTCTAGATTAATGCAAACCACTTCATCAGCGGAGGTCGTA AAACGTATCTTTACCTATTTGGCTTGTTCATTATGCGTGTGGTATTACTTTATTTTTTTTTTTTGCAGACCAGGTGCA GTTGGGTTAAAAATAGTTACATATCGAACGCCTTCGGTGCGAATTTTTTTTTCTGGATTTTCACATTCACTTGCGGC GATGGCCATTAGAGCATTACCCACTTAGGGCTCCCTAAAAATCCAGGTGGTCCACAGGGACCACAAAAAATATTG CAAATTACAGGCACTTGAGTGCTTCCTTAACTCTTTGAACACTTTACTTATGCAACTCTCAAATTGTATGTACGAAA TGAAATGTATGCTAAAAATCACCTGCCCATAATTACGCGGAAACCACTTTTTGACCCTCGGTGAATTGTGAATCA TCGGAACTGCCCAACTGCCAATCGAAATCAAAGCTAAACCAATCGAAACCAGCCAAGTAATTCAAATTTAATG CTGTTCAAGAAATACCTGCTTTGTATACTCTATCTATACGATTTACTATAATGATAAATTATACTAATATCTGGCTT ATTTGCATATATGTCATAAAATAGAAATAAGTGCACTGGTCATATAAATTGAACATATTTATCAACGGGCTTTCAA AAAATAATGAGAAATAATTAAATCTGACTTTCAAAAATTACAAATTAAATTACTGTTTTTTTTTTTAATACTTTGA AAGTTGTTTATAGATAAAATATTTTTGAAGATGTCACACTGATATTAAGCTTAAAGCTTTAAAATATTTTGCAAC AAAGAATTTTACAAGTTTTTATTAAACGGAGCCGTTCCGTTTTTGGTGCGAAAGCCGAAAATTGCATTTTATGCAC AAACCTGCCAGCCTAAAAAGTGTGCTCAAAAATAGTATGAATACTAAATGAATGAATAAACCTGGTAAAAATAAT GTCTAACTTGAGTCCATTATATTTATTAAATATACAGTACAGCAATATACATAACTTTTAGTCTTTAAGAAATCAA TGTTTGTAATGTCATCCAGCTTTAATGTATTTTGCAATAGAACAATGTAGTTAAGAAATTTATTTATGTTCATGAAT CTGACAAATTGTGACTAGCGCTTTAATTTATAAGTATTTTTGTACTTGTAGCGTTAGGAAGAAATAAAACCAAAA TTAAATTAAAAATATACAGCAACTTTATATTTTGTAATTAATTTACTCATAAATCAGCAAAATCTCAAATTCAGCTG AAGGCCAGGAATTTCAAAGAATTCAGCGTGCCAAAAACCAAAAAACCCTTTCAAAAGTGTATGAAAAATTGGCAA TCCCAGCGAAAGGTGACTCGGCTGACTCGGTGAATTTTGAGGGTTCGAGATACTCGTATTTATTAAAACATGCGTG AAAATCAATCACTGAATACAAAAAGCCACGCACTAAAAAATAAATGCCCGAAGTTTAGACCACCACCGGCCGAACC ACTGGAACCAG

>BP5
CAAGAGCCCAAGGTCGGTCGTTTAGCTTGGCCAAAACCTACCCATCCAGCTGGCACTTCCACCAACGGCACCAAG
ACACGAGCGGAAAATAAAAAGCCACACCACCCCACTTAGAACTCCGTTTAGCAGCAGTTGTTCAAACAGAAATTG
GCTGGCTTCGGCCGGTTCAGCtTCAGTTGATAATTATTATAATATCTATGTTCTTGCCTATCGCTGGGCCCTAATTGG
CCCAGACAAAGGCACCGTTTTATGCATAACTGGAGGCTTACAATTTGGCTTTCGACACGCGGTCCTTCACATTGC
CAAAAAGAACGAGAACTCAGCAAGCCAATTACACTCGAAAAAGCAGCGGGGATCGTTTCGATGCCTAGCCCTGGG
CTAGTTCAATCACTCCCGCATAATTGGCCCTCTGCAATGGAGATCGAGATCGATTCTTGGG
AAAACACCTCCTCAGTTTCCATTTCTGTTTTTTGGGTCCGGAAGTGGCATCGTGTCCTTCCAGAAGCGCCTCCAAAT
GGTGCCACCATTAGCCAGGGGAAGCCGGGCGGCAGTCACTTAGCTGCTGCAATTTAAATACTTTTTAATTGATTA
CTAATTGCGGCGAGGCAAGTGCCAAAACAAGACGACGAGGACGACTTGGCTGTGACGTTTTCGATGCAACCCGAC
CGGGGACTGCCACTCTTTAGCCAGTTAATTGGCAGCAAAAGCGACAGTGGCAGCGGCAGCAACTGCTTTTCACCA
GGAAATCAATAAACGCTCGTCCAGCGGCAAAAGTAATCGCAACACGCACATCTCAATTTCGGTGGCAGAAAAAAA
ACCCTCACCAGCTCAATTCCCCGTGCCAAATTAACCAGAGCAAACATAGCCCAGTTTCTTCTCCTGCGGCATGTGA
AAAGGCAAACAGTGCTGGCCGGAAAATACCAGCAAACACCTGAGTTCTAGTTGCGATTTTCGGAATTGGACTA
TAAAAGGCGGCCGTCGGGTAGCTTTCTCACTCACAACCAGTCCAAAAGCATCTCCAACATGAAGTTCTCCAGCA
AATCGTCCTGGGTCTGGTGCTCGTCCTGGCCATCATGGGTCGCTGGCCAGCGCCAAGCCCCAGGAGGCCGAGGA
ACCGGAGGAGTCGCTGGTCGGGGACTCAGAGTCGGGACAGTCCGTGCCCGAGGACGCCCAGCAGGACTACCTCAA
CGTGGCGGACTTCACCACTGCCGCTCCTACATGGTGGTGGAACTAGAGCCCGGGAATTCTAGAGGATTTAACAAT
CTTTTGTTTTTTTTTGCTAATCTAATGTACTATAATTGCAAAGAATTTATGGTGTCCATATTCAATAAACCTATTTA
AAGCTGAATATAATGTAAACCGTATATAAATGTTCTTGTATGATACATTTTACTAAATTAAAAAGTTAAATAATTA
AAATATTTAATTTACTCATTGTGGGAGTTCATTAGACTTATTGTTTGTTTTTATTAAATTGTAATTTGTATCAAAAGT
TTAAGTTAAAGTCTTAAAAATATATATCAAGTTCATTGCACAAATTAACTAAAAATATGTACCAAAAATGTAGAAA
TCAACCTATTTAATCTAAATGTAAATAAATGTAACAAACCAATCATGTCTTAAATTAAATATGTTTTTAAGCCTAAC
ACTTATATTTAAAAAAATAATTATAATTCAGACTTAAATTTTAAAAATCGTCTCACCTTTTTTAGTTTATTGATGCAT
GTTTTAATTTTGCTAAAAATCGTATTTTGATGTCTATTCATTTTGCCAGCCAGTAATCTAAAAAGTCGACCTATCACT
CTCCCCCTCTTATATTCGACCTATAAATACCCACCGCAAATGCCGCAACCAACCTAACCCACAGAGCCAGTTCGG
GTTGTTTAATGGACAATTATCCTTAGTTCAGAAaGCGCCTGCCTTTATGCGTATTTCCCCGCTTGCCCTGCGAATACG
CCTAACGAAATTTACTCGAGCCCGTAAACCCAGTTTCGGTAAGTGCTCTTTATGAATATTTTCCATTTACTTTAAT
TGAAAGCTGCCAATTGTGGTGGACTGCTGGCCAATGAGGCGGTAAATACGTTAAGTCGGAGCTGC
GGAACGGGATGATGGACCAGTTGAGGCGAAGTACATCAATCTCATTTGCCCGCACTTATCGAACGGTTGCCTTGGG
GAGATCGCTGCGATTGCTTATCGATAATCGCCCGATTACCGCGCTGAGCGGTCTTAAGACCCATAAGAAATGCGG
CGATGGCGGCTTTAGATAAGTAAGTCGTCGGGGCGCTCATAAATTTCGAGCGCGATCCACGGATTTATGCACTCGC
TGGAAAAGCTATTACCATTAGGCTTTTCGACCACGGATTTTCCGCTTGCCCTGAGACAAAGTGGCGCGGCAGT
TGCAGGCAAATTATGTGTGAGGCAATGCCGCGGGCATGTCTACACCGAAATCAAATTACGGCAACCTCTATTCACT
TATTTGCTTAGTTTTTTGCGCAGTGAGCGGCCAGCGCCTTGTATTGGCATCTAATTATCCGTTTAAGGACGCAATT
TTCTGAGCTAAAACTCGCTTATGGAGAGATCTAAATTTCCCCGCTTTTGGCTTGAATAAATTAATCGAATCCCCGC
TGGCTATTAAAAACACACAAAAAGGCGCTCTCGTCTGTTTCAATGTAAATTGCAAATTGCTCAATCCGCCTAATTGAT
GTGCGCCCATGCAATAGTTTTGTGCCAATCATTTTTAGTACACCCCTAACTGGTGTTTTCTACGCATAATATGTGCC
ATGGCTTAGGGCCTTTTGGTGGACTTACCAACTGAAGAAGACGATTGTGGGGGTGCGTTTGGCGCAGTGCACGCCT
GCGAGCAGGAAATCTCTTTCTCGCCTGTCTGATTTTGGCCAAGACAAATAAATCCGGCTGGCAGATAGGCAGAG
GGGACCCGCGGTCAGGGCCGTGGACATTGAACTTGAAAACGCAGCCAGCGCCGAAAACATTGTATTCAACGAAC
GGCAAGTGCTGCGGTCATGGTGCTCTGGCTAAGGTTACGGCGGTTGGGCAACAGGTTTCCCCGCCAACAC
TGGGAGGAGAAAATAAAAAGGAAAATGTTCAGGCTGCCATAAGTGGGGAAAAAGGAAAACAAAACATGAAACAC
GGGCCGGGCAATGTCACTCGGCATTCGCTTGATTTTCCGCCTAACTCGCAGCGGTCCTGTGTGTAATAATGTCTA
ATGTTGCATGCCGGTTGCATAATCGTGTGGCAATTATGCCAGAGAGATTCGCTTATTTATTTTTTACTTTCTGCCAT
GTTCCGCTGCCACCGTATTTCTTTTCGGCCACTTAGTGCGCTCCGCTTGATAATGATGTTTTGTTTTTCGCGGGACA
AACTCGTTTCAATTATTGGGAAAAGCGCGTATAAATCATCGCCGCCAAAGTCTGGCAAACAGCAAATTGAAAAC
TGCAATCTGAAAACTGAAAAACTGAAAACTGTAACCCAAACAAACACAGCATCCCACACGACGAGATGAAAATGA
AAATAAATACGGACTGAGCGACTGAAAACAAGTCAATTCGATTCAAATTGCAGGTTCAACGGCTGCCGGCGATCG
CATCATTAAAGTGCGCCTTCGCTGGATACGGGCTCTTATGCAACGAGCACACACAATTAATTAATAAGCGTCTGGT
TGTTTCGGCCTGGCTTTTGCGGACCTGCCGATCGCAATAAATTAAGGCAGCATTAGTCGCAATTATGTGCCACATA
GTTGGGCTGCTTACTTTTCTGTGGGTGAGCCGAGCGCAGAATGCGGCCAAGGGATCGAGTTAAACCGCTTTTCCGC
AGGCCAAGAGTTTTTCGCATTTTGCATAAAATCGGCAACGCATAAGTGGCGAAGCATTGATGAAACTGCGGGAAA
AGAAGTAAAAAATATTTAAAAAATAAATATAAATTTATGGCAGAACTTAAGAAACTAATTTGAAATACTCCTCCTCT
CCTTAAGAAACTGTCCCTAGGAATATTTGTTTCCCCAGCATTGCTCAATATTCCTCCATCTTTTTGCTTATTTCCC
AGACATTTTCCTTGGCCGAAGTGTAGCTGGTGGGTCTCCAGATTAATGCAAACCACTTCGTCAGCGGAGGTCGTAA
ACGTATCTTTGCCCATTTGGCTCGTTCATTATGCGTGTGGTATAGCTTTATTTTGCCATTTTCCCTCTTTTTGCAC
CAGCTGCAGTTGGGCCAAGAGAGTTATGCGAATCGGTGCGATTTTCGGGTTTTCGCACTCGCTTGCGGCCATGGCC
ATTAGAGCACATTTCCCACTTAGGGCTCCCAAAATCCAGGTGGTCCCAACAGGGACCACCAAAAATATGCCAAATTAC
AGGCACTTGAGTGCTTCCTTAACTCTTTGAACACTTTACTTATGCAACTCTCAAATTGTATGTACGAAATGAAATGT
ATGCTAAAAATCACCTGCCCATAATTACGCGGAAACCAACTTTTTGACCCTCGGTGAATTGTGAATCATCGGAACT
GCCCAACTGCCCAATCGAAATCAAAGCTAAACCAATCGAAACCAGCCCAAGTAATTCAAATTTAATGCTGTTCAA
GAAATACCTGCTTTGTATACTCTATCTATACGATTTACTATAATGATAAATTATACTAATATCTGGCTTATTTGCAT
ATATGTCATAAAATAGAAATAAGTGCACTGGTCATATAAATTGAACATATTTATCAACGGGCTTTCAAAAAAATAAT GAGAAATAATTAAATCTGACTTTCAAAAATTACAAATTAAATTACTGTTTTTTTTTTTAATAACTTTGAAAGTTGTT TATAGATAAAATATTTTTGAAGATGTCACACTGATATTAAGCTTAAAGCTTTAAAATATTTTGCAACAAAGAAT TTTACAAGTTTTTATTAAACGGAGCCGTTCGGTTTTGGTGCGAAAGCCGAAAAATTGCATTTTATGCACAAACCTGC CAGCCTAAAAGTGTGCTCAAAAATAGTATGAATACTAAATGAATGAATAAACCTGGTAAAAAATAATGTCTAACT TGAGTTCCATTATATTTATTAAATATACAGTACAGCAATATACATACTTTTAGTCTTTAAGAAATCAATGTTTGTA ATGTCATCCAGCTTTAATGTATTTTGCAATAGAACAATGTAGTTAAGAAATTTATTTATGTTCATGAATCTGACAAA TTGTGACTAGCGCTTTAATTTATAAGTATTTTTGTACTGTAGCGTTAGGAAGAAATAAAACCAAAATTAAATTAA AAATATACAGCAACTTTATATTTGTAATTAATTTACTCATAAATCAGCAAAATCTCAAATTCAGCTGAAGGCCAG GAATTTCAAGAATTCAGCGTGCCAAAAACCAAAAAACCCTTTCAAAAGTGTATGAAAAATTGGCAATCCCAGCG AAAGGTGACTCGGCTGACTCGGTGAATTTTGAGGGTTCGAGATACTCGTATTTATTAAAACATGCGTGAAAATCAA TCACTGAATACAAAAGCCACGCACTAAAAAATAAATGCCCGAAGTTTAGACCACCACCGGCCGAACCACTGGAAC CAG

## PB-series (*D. prostipennis* + *D. biarmipes*)

>PB1

AACCTACCCATCCAGCTGGTAATTCCACAGAAACACCAAAAAAAACTAAATAAACTACACCACCCCACTTA GAACTCCGTTTAGCAGCAGTTGTTCAAACAAAAATTAGTTGGCTTCGGCCGGTTCAGCTTCAGTTGATAATTATTAT AATATTTATTGTTCTTGCTGCTGCTGCTGCCTATCGCTAAATTATTAATTGCTCAAGACAAAGGCACAGTTTTATG CATAATTAGAGGCTTACAATTTGGGTTTCAGCACACACAATCCTTCACATTGCCAAAAAAAACAAAAAAAAG ATTAAAAAATAATAAAATACGAATTATAACACTAATTACACTCGAAAAAGCAGCGGGGATCGTTTCACCACAATC GATCGATATTTAACCCTGGACGAGTTCAACCACTCCCGCTGATAATTGCCCAAGTTCTGTAATTGGAACTTTCAAA GATGATGATGTTGTTCCTTGATCAAGTTCTCAAGATTACCAACATAATCGTTAAATATTAAGAAAAATCACAACCTC TTAATGATTATCATCTAATCATAAGCAAGCAATCTATATGTATATCAAACTTAATTTATAATAATTATAATTTTA AGAATCAAACCCAAACTACCAATATTAAAATATATACCTATATATTTTTTATATCCCACTCAACTTTAAAATCGA GGAAGTGCCATCGCTGGTATCTTCCCAGAAAAGTTGCCAAATGGCTAATGATACCATTAAGCCAGGAGGAAGCCA AATAACAGTCGCTTAGCTGTTGATCAAGTTTAATAGTTTTTAATTGATAACTATGGCGTGAGCGAGTGCCAAAAC AAGACAGTGGACGACATGGCTGTGACGTTTCAATGTTGCAACATGGGGTAGCATTGCAACTCTTTAGCCAGTTAA TTGGCAGCAAAAGCGACAGTGGCAGCAGCAAATACAGCTTTTCACCAGGAAATCAATAAACGCTCGTCCAGCGGC AAAAGTAATCGCAACACGCACATCTCAATTTCGGTGGCAGAAAAAAAACCCTCACCAGCTCAATTCCCCGTGCCA AATTAACCAGAGCAAACATAGCCCAGTTTCTTCTCCTGCGGCATGTGAAAAGGCAAACAGTGCTGGCCGGAAAAT ACCCAGCAAAACACCTGAGTTCTAGTTGCGATTTTCGGAATTGGACTATAAAAAGGCGGCCGTCGGGTAGCTTTCTT CACTCACAACCAGTCCAAAAGCATCTCCAACATGAAGTTCTTCCAGCAAATCGTCCTGGGTCTGGTGCTCGTCCTG GCCATCATGGGTCGCTGGCCAGCGCCAAGCCCCAGGAGGCCGAGGAACCGGAGGAGTCGCTGGTCGGGGACTCA GAGTCGGGACAGTCCGTGCCCCGAGGACGCCCAGCAGGACTACCTCAACGTGGCGGACTTCACCACTGCCGCTCCT ACATGGTGGTGGAACTAGAGCCCGGGAATTCTAGAGGATTTTAACAATCTTTTGTTTTTTTTTGCTAATCTAATGTA CTATAATTGCAAAGAATTTATGGTGTTCATATTCAATAAACCTATTTAAAGCTGAATATAATGTAAACCGTATAT AAATGTTCTTGTTATGATACATTTACTAAATTAAAAGTTAAATAATTAAAATATTTAATTTACTCATTGTGGGAGT TCATTAGACTTATTGTTTGTTTTTATTAAATTGTAATTTGTATCAAAAGTTTAAGTTAAAGTCTTAAAATATATATCA AGTTCATTGCACAAATTACTTAAAAATATGTACCAAAAATGTAGAAATCAACCTATTTAATCTAAATGTAAATAA ATGTAACAAACCAATCATGTCTTAATAGTTTTTAAGCCTAACACTTATATTTAAAAAATATATATATTAATTC AGACTTAAATTTTAAAATCGTCTCACCTTTTTTTTAGTTTATTTGATGCATGTTTTAATTTTGCTAAAATCGTATTTTG ATGTCTATTCATTTTGCCAGCCAGTAATCTAAAAAGTCGACCTATCACTCTCCCCCTCTTATATTCGACCTATAAA TACCCACCGCAAATGCCGCAACCAACCTAACCCACAGAGCCAGTTCGGGTTGTTTAATGGACAATTATCCTTAGTT CAGAAaGCGCCTGCCTTTATGCGTATTTCCCCGCTTGCTGCGAATACGCTAACGAAATTTACTCGAGCCCGTAAA CCCAGTTTCGGTAAGTGCTTCTTTATGAATATTTTCCATTTACTTTAATTGAAAGCTGCCAATTGTGGTGCCCGAGT GTTGTGACTGCTGGCCAATGAGGCGGTAATACGTTAAGTCGGAGCTGCGGAACGGGATGATGGACCAGTTGAGGC GAAGTACATCAATCTCATTTGCCCCGCACTTATCGAACGGTTGCCTTGGGGAGATCGCTGCGATTGCTTATCGATAA TCGCCCGATTACCGCGCTGAGCGGTCTTAAAGACCCATAAGAAAATGCGCGATGGCGGCTTTAGATAAGTAAGTC GTCGGGGCGCTCATAAATTTCGAGCGCGATCCACGGATTTATGCACTCGCTGGAAAAGCTATTACCATTAGGCTTT TCGCGACCACGGATTTTCCGCTTGCCTGAGACAAGTGCGGCGCGGCAGTTGCAGGCAAATTATGTGTGAGGCAAT GCCGCGGGCATGTCTACACCGAAATCAAATTACGGCAACCTCTATTCACTTATTTGCTTAGTTTTTTGCGCAGTGAG CGGCCAGCGCCTTGTATTGGCATCTAATTATCCGTTTAAGGACGCAATTTTCTGAGCTAAAACTCGCTTATGGAGA GATCTAAATTTCCCCGCTTTTGGCTTGAATAAATTAATCGAATTCCCCGCTGGCTATTAAAACACACAAAAGGCGC TCTCGTCTGTTTCAATGTAAATTGCAAATTGCTCAATCCGCCTAATTGATGTGCGCCCATGCAATAGTTTTGTGCCA ATCATTTTTAGTACACCCCTAACTGGTGTTTCTACGCATAATATGTGCCATGGCTTAGGGCCTTTTGGTGGACTTA CCAACTGAAGAAGACGATTGTGGGGGTGCGTTTGGCGCAGTCACGCCTGCGAGCAGGAAATCTCTTTCTCGGCCT GTCTGATTTTGGCCAAGACAAATAAATCCGGCTGGCAGATAGGCAGAGGGGACCCGGCGGTCAGGGCCGTGGACA TTGAACTTGAAAACGCAGCCAGCGCCGAAAACATTGTATTCAACGAACGGCAAGTGCTGCGCGGCATGGGTGTCT CTGGCTAAGGTTACGGCGGTTGGGCAACAGGTTTCCCCCGGCCAACACTGGGAGGAGAAAATAAAAAGGAAAAT GTTCAGGCTGCCATAAGTGGGGAAAAAGGAAAACAAAACATGAAACACGGGCCGGGCAATGTCACTCGGCATTC GCTTGATTTTCCGCCTAACTCGCAGCGGTCCCTGTGTGTAAATAATGTCTAATGTTGCATGCCGGTTGCATAATCGTG
TGGCAATTATGCCAGAGAGATTCGCTTATTTATTTTTTACTTTCTGCCATGTTCCGCTGCCACCGTATTTCTTTTCGG
CCACTTAGTGCGCTCCGCTTGATAATGATGTTTTGTTTTTCGCCGGGACAAACTCGTTTCAATTATTGGGAAAAGCG
CGTATAAATCATCGCCGCCAAAGTCTGGCAAAACAGCAAATTGAAAACTGCAATCTGAAAACTGAAAACTGAAAA
CTGTAACCCAAACAAACACAGCATCCCACACGACGAGATGAAAATGAAAATAAATACGGACTGAGCGACTGAAA
ACAAGTCAATTCGATTCAAATTGCAGGTTCAACGGCTGCCGGCGATCGCATCATTAAGTGCGCCTTCGCTGGATAC
GCGGCTCTTATGCAACGAGCACACAAATTAATAAGACGTGTTGTTTCGGCTGCTTTTCGGGACCTGC
CGATCGCAATAAATTAAGGCAGCATTAGTCGCAATTATGTGCCACATAGTTGGGCTGCTTACTTTTCTGTGGGTGA
GCCGAGCGCAGAATGCGGCCAAGGGATCGAGTTAAACCGCTTTTCCGCAGGCCAAGAGTTTTTCGCATTTTGCATA
AAATCGGCAACGCATAAGTGGCGAAGCATTGATGAAACTGCGGGAAAAGAAGTAAAAAATATTTAAAAATAAAT
ATAAATTTATGGCAGAACTTAAGAAACTAATTTGAAATACTCCTCCTCTCCTTAAGAAACTGTC CCTAGGAATATTT
GTTT TCCCAGCATTGCTCAATATTTCCTCCATCTTTTTGCTTATTTCCCAGACATTTTCCTTGGCCGAAGTGTAGCT
GGTGGGTCTCCAGATTAATGCAAACCACTTCGTCAGCGGAGGTCGTAAACGTATCTTTGCCCATTTGGCTCGTTCAT
TATGCGTGTGGTATAGCTTTATTTTTGCCATTTTTCCTCTTTTTGCACCAGCTGCAGTTGGGCCAAGAGAGTTATG
CGAATCGGTGCGATTTTCGGGTTTTCGCACTCGCTTGCGGCCATGGCCATTAGAGCATTACCCACTTAGGCGCCCT
AAAGTCCAGGTGGTCCCCAGGGACCACAAGAGTATTGCAACTTACGGCCAGCTGAGTGGAGTGCCGGAACGCACT
TCTTAATTCGGCGGTTATGTAACCTCGAGCTGAGTGTGCGATACATATGCCAAAATCACCTGCTCATAATTAGCG
GAAACCACTGTTTGGCCCTCGCCGGACTGTGAATCATCAGAGCTGCCCAATCGAAATCAAAGCCAAGCCAATCG
AAGCCCAGGTAATTCATATTTAGTGCTGCTTCGCAAaGACCTGTCCCAGATACTCTGTTTATAGGTATAATTATTAA
GTGCATATCAGGTTTATTTACATTTATATCGTATAATATTGGTAACTGCAGCAGCTGCTGTGCTCCAAATTTAGAAT
CATTTAAAACAAGCCTATTTGCCACAGAAAATGTGTGAAATAATTAACTAAAAGCTTTGGATGAAGTAAAAAAG
CCATAAAGCCTAAAATAATATTATGAATAATCAAAGAAAATCAGTAGATGGTAAAGTACTTCGTACCTACGTTGCA
TGGTATTCAATAAAGATTCAAAAATACTCTCACCCACTGTAAGTGAACCCAGTATTTTGTAAATTGCCTAGCACATA
AATCAGCTGAATCCTAAACGTATCTGAAGGCCAGGAGTGTCGGAGAATTCGGTGTGCCAAAAAACCAAAGACCAA
GACCATACCCTTTCAAAACCTTATGAAAAATGGCAAGCCCGGCGAAAGGTGTTGGCCGGTCCAGGGGATTCGGGG
GCCCGAGATACTCGCACTTAATAAACATGCGTGAAAATCAATCAGCGAAGACAAAAGCCACGCACTAGAAGAAA
CCAAAGTGTC CGAAGTGGCCGATCCACGGGTGACCATATAGACCATAAAGTCCGCATGGTGGACCACCACCCGAG
CCACCGAAAGCAG

>PB2

AACCTACCCATCCAGCTGGTAATTCCACAGAAAACACCAAAAAAAACTAAATAAACTACACCACCCCACTTA
GAACTCCGTTTAGCAGCAGTTGTTCAAACAAAAATTAGTTGGCTTCGCCGGTTCAGCTTCAGTTGATAATTATTAT
AATATTTATTGTTCTTGCTGCTGCTGCTGCCTATCGCTAAATTATTAATTGCTCAAGACAAAGGCACAGTTTTATG
CATAATTAGAGGCTTACAATTTGGGTTTCAGCACACACAATCCTTCACATTGCCAAAAAAAACAAAAAAAG
ATTAAAAAATAATAAAATACGAATTATAACACTAATTACACTCGAAAAAGCAGCGGGGATCGTTTCACCACAATC
GATCGATATTTAACCCTGGACGAGTTCAACCACTCCCGCTGATAATTGCCCAAGTTCTGTAATTGGAACTTTCAAA
GATGATGATGTTGTTCCTTGATCAAGTTCTCAAGATTACCAACATAATCGTTAAATATTAAGAAAATCACAACCTC
TTAATGATTATCATCTAATCATAAGCAAGCAATCTATATGTATATCAAACTTAATTTATAATAATTATAATTTTA
AGAATCAAACCCAAACTACCAATATTAAAATATATACCTATATATTTTTTATATCCCACTCAACTTTAAAATCGA
GGAAGTGCCATCGCTGGTATCTTCCCAGAAAAGTTGCCAAATGGCTAATGATACCATTAAGCCAGGAGGAAGCCA
AATAACAGTCGCTTAGCTGTTGCGATTTAAATAGTTTTTAATTGATAACTAATTGCGGTGAGGCGAGTGCCAAAAC
AAGACAGTGGACGACATGGCTGTGACGTTTCAATGTTGCAACATGGGTAGCATTGCAACTCTTTAGCCAGTTAA
TTGGCAGCAAAAGCGACAGTGGCAGCAGCAAATACAGCTTTTCACCAGGAAATCAATAAACGATAGTCAAGCCAA
GAGAAGAAAAACAAGCACAACACGCACATCTCAATTTCAGTAGTAGCAAAAAACAAAATAAAATAGAGAGATAA
AGATAAAGAAAAAGAAATAAAAACCAACCCTGACCAACTCAATTTCTCGTGCCAAAAATAAAAGCAAATATAGCC
CAGTTTTAATATGAAAATACAACAATCTAATTTTGGCTGGAAAATACCCAGAAAAAATAACACCTGAGTTCTAG
TTCCGATTTGTATAATGTTGGACTATAAAAGGCAGCCGTAACTTTCTCACTCACAAGTCCTCACAAGTATTGCAA
CATGAAGCTGTTCCAACAAATAATCCTGGGTCTGGTGCTCATCTTCGCCGTAAATGAGTTCTCTGTCGACTGCTCAGC
CCCTTAAGGATGATGAATCCCTTATTGGGGACTCGGAATCGAATGAAACTATACCCGATGACGTCCAACAGGATTA
TCTCAATGTGGCAACTACGTGACTGATGCTCCTCCATGGTGGTGAACTAGACGTTTCAAAAGGATTTAGAAAAAT
GTTTTATTCTTTTTTTTGTGTGTGTTATTATTTTATTAAATTGATGTATTAAAATTACAATATACTAAACCCATTGAA
ACAAGAATATCATGTTGATAAATGGGGTGAAAATAAAATGAAAATTATTATAAAATTAATTAAATTATAAAATAA
CATTTAAAAAATCCATATTTTGTATTGTTATTATTATGTTTTTTTGCAACAAATATTTTATTTGCAATCACTTCA
ATTTCGGTTTTAATATHTCGAAATCATCTTTTTCATAAACCCCAAAAAACCAGTTTTTTTTTTTTTAACGATCAATT
ATCCTTAGTTCAGAAaGCGCCTGCCTTTATGCGTATTTCCCGCTTGCCTGCGAATACGCCTAACGAAATTTACTCG
AGCCCGTAAACCCAGTTTCGGAAGTGCTTCTTTATGAATATTTTCCATTTACTTTAATTGAAAGCTGCCAATTGTG
GTGCCCGAGTGTTGTGACTGCTGGCCAATGAGGCGGTAATACGTTAAGTCGGAGCTGCGGAACGGGATGATGGAC
CAGTTGAGGCGAAGTACATCAATCTCATTTGCCCGCACTTATCGAACGGTTGCCTTGGGGAGATCGCTGCGATTGC
TTATCGATAATCGCCCGATTACGCGCTGAGCGGTCTTAAGACCCATAAGAAAATGCGGCGATGGCGGCTTTAGAT
AAGTAAGTCGTCGGGGCGCTCATAAATTCGAGCGCGATCCACGGATTTATGCACTCGCTGGAAAGCTATTACCA
TTAGGCTTTTCGCGACCACGGATTTTCCGCTTGCCTGAGACAAGTGCGGCGCGGCAGTTGCAGGCAAATTATGTG
TGAGGCAATGCCGCGGGCATGTCTACACCGAAATCAAATTACGGCAACCTCTATTCACTTATTTGCTTAGTTTTTTG
CGCAGTGAGCGGCCAGCGCCTTGTATTGGCATCTAATTATCCGTTTAAGGACGCAATTTTCTGAGCTAAAACTCG