Removing 110 µm of Pb-enriched secondary dentinee surface:

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD_wSDS$Sr and Od533M_SD_wSDS$Pb<br>t = 6.8029, df = 135, <strong>p-value = 3.039e-10</strong><br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>0.3688022 0.6204068<br>sample estimates:<br><strong>cor</strong><br>0.5052651</td><td>Spearman's rank correlation rho<br>data: Od533M_SD_wSDS$Zn and Od533M_SD_wSDS$Pb<br>S = 106274, <strong>p-value < 2.2e-16</strong><br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br><strong>rho</strong><br>0.7520068</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] 0.4864732</td><td></td></tr></table>

Classical cor = 0.51 Robust cor = 0.49

<figure><img src="image_133.png" /></figure>

• Sr vs Zn

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD$Zn and Od533M_SD$Sr<br>t = 9.0389, df = 188, <strong>p-value < 2.2e-16</strong><br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>0.4427294 0.6424145<br>sample estimates:<br><strong>cor</strong><br>0.5503947</td><td>Spearman's rank correlation rho<br>data: Od533M_SD$Zn and Od533M_SD$Sr<br>S = 405396, <strong>p-value < 2.2e-16</strong><br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br><strong>rho</strong><br>0.6453647</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] 0.7399384</td><td></td></tr></table>
Classical cor = 0.55 Robust cor = 0.74

<figure><img src="image_134.png" /></figure>

• Pb vs Zn

Whole secondary dentinee thickness:

<table><thead><tr><th></th><th>Pearson's product-moment correlation</th><th>Spearman's rank correlation rho</th></tr></thead><tbody><tr><td>Classical test</td><td><p>data: Od533M_SD$Zn and Od533M_SD$Pb</p><p>t = 5.5906, df = 188, <strong>p-value = 7.874e-08</strong></p><p>alternative hypothesis: true correlation is not equal to 0</p><p>95 percent confidence interval:</p><p>0.2485614 0.4933909</p><p>sample estimates:</p><table><tr><td><strong>cor</strong></td><td><strong>$cor rob</strong></td></tr><tr><td>0.3775555</td><td>[1] 0.6087622</td></tr></table></td><td><p>data: Od533M_SD$Zn and Od533M_SD$Pb</p><p>S = 411004, <strong>p-value < 2.2e-16</strong></p><p>alternative hypothesis: true rho is not equal to 0</p><p>sample estimates:</p><table><tr><td><strong>rho</strong></td><td><strong>0.6404589</strong></td></tr></table></td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td colspan="2">[1] 0.6087622</td></tr></tbody></table>

Classical cor = 0.38 Robust cor = 0.61

<figure><img src="image_135.png" /></figure>
Removing 110 µm of Pb-enriched secondary dentinee surface:

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD_wSDS$Zn and Od533M_SD_wSDS$Pb<br>t = 13.47, df = 135, p-value < 2.2e-16<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>0.6752670 0.8207112<br>sample estimates:<br>cor<br>0.7572247</td><td>Spearman's rank correlation rho<br>data: Od533M_SD_wSDS$Zn and Od533M_SD_wSDS$Pb<br>S = 106274, p-value < 2.2e-16<br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br>rho<br>0.7520068</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] 0.7244165</td><td></td></tr></table>

Classical cor = 0.76 Robust cor = 0.72

<figure><img src="image_136.png" /></figure>

• Zn vs Ca

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD$Zn and Od533M_SD$Ca<br>t = 7.0081, df = 188, p-value = 4.196e-11<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>0.3344273 0.5611145<br>sample estimates:<br>cor<br>0.4551141</td><td>Spearman's rank correlation rho<br>data: Od533M_SD$Zn and Od533M_SD$Ca<br>S = 560218, p-value < 2.2e-16<br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br>rho<br>0.5099284</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] 0.6601464</td><td></td></tr></table>
<figure><img src="image_137.png" /></figure>

• Zn vs Fe

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD$Zn and Od533M_SD$Fe<br>t = -2.455, df = 188, p-value = 0.015<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>-0.31080458 -0.03476824<br>sample estimates:<br>cor<br>-0.1762492</td><td>Spearman's rank correlation rho<br>data: Od533M_SD$Zn and Od533M_SD$Fe<br>S = 1399172, p-value = 0.001936<br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br>rho<br>-0.2239779</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] -0.3170197</td><td></td></tr></table>

Classical cor = -0.18 Robust cor = -0.32

<figure><img src="image_138.png" /></figure>
• Zn vs Cu

<table><thead><tr><th></th><th>Pearson's product-moment correlation</th><th>Spearman's rank correlation rho</th></tr></thead><tbody><tr><td>Classical test</td><td>data: Od533M_SD$Zn and Od533M_SD$Cu<br/>t = -1.4594, df = 188, p-value = 0.1461<br/>alternative hypothesis: true correlation is not equal to 0<br/>95 percent confidence interval:<br/>-0.24450631 0.03707514<br/>sample estimates:<br/>cor<br/>-0.1058368</td><td>data: Od533M_SD$Zn and<br/>Od533M_SD$Cu<br/>S = 1193286, p-value = 0.5475<br/>alternative hypothesis: true rho is not<br/>equal to 0<br/>sample estimates:<br/>rho<br/>-0.04387146</td></tr><tr><td>MCD<br/>(α=0.05;<br/>quant=0.8)</td><td>$cor.rob<br/>[1] 0.009811241</td><td></td></tr></tbody></table>

Classical cor = -0.11 Robust cor = 0.01

<figure><img src="image_139.png" /></figure>

• Zn vs Mg

<table><thead><tr><th></th><th>Pearson's product-moment correlation</th><th>Spearman's rank correlation rho</th></tr></thead><tbody><tr><td>Classical test</td><td>data: Od533M_SD$Zn and Od533M_SD$Mg<br/>t = 9.3848, df = 188, p-value < 2.2e-16<br/>alternative hypothesis: true correlation is not equal to 0<br/>95 percent confidence interval:<br/>0.4594057 0.6545460<br/>sample estimates:<br/>cor<br/>0.5648209</td><td>data: Od533M_SD$Zn and<br/>Od533M_SD$Mg<br/>S = 457680, p-value < 2.2e-16<br/>alternative hypothesis: true rho is not<br/>equal to 0<br/>sample estimates:<br/>rho<br/>0.5996273</td></tr><tr><td>MCD<br/>(α=0.05;<br/>quant=0.8)</td><td>$cor.rob<br/>[1] 0.6538013</td><td></td></tr></tbody></table>
<figure><img src="image_140.png" /></figure>

• Ca vs Fe

<table><thead><tr><th></th><th>Pearson's product-moment correlation</th><th>Spearman's rank correlation rho</th></tr></thead><tbody><tr><td>Classical test</td><td>data: Od533M_SD$Ca and Od533M_SD$Fe<br/>t = 8.0258, df = 188, <strong>p-value</strong> = <strong>1.063e-13</strong><br/>alternative hypothesis: true correlation is not equal to 0<br/>95 percent confidence interval:<br/>0.3909232 0.6040775<br/>sample estimates:<br/><strong>cor</strong><br/><strong>0.5051645</strong></td><td>data: Od533M_SD$Ca and<br/>Od533M_SD$Fe<br/>S = 832466, <strong>p-value</strong> = <strong>0.0001572</strong><br/>alternative hypothesis: true rho is not<br/>equal to 0<br/>sample estimates:<br/><strong>rho</strong><br/><strong>0.2717693</strong></td></tr><tr><td>MCD<br/>(α=0.05;<br/>quant=0.8)</td><td colspan="2">$cor.rob<br/>[1] -0.05379779</td></tr></tbody></table>

Classical cor = 0.51 Robust cor = -0.05

<figure><img src="image_141.png" /></figure>
• Ca vs Mg

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD$Ca and Od533M_SD$Mg<br>t = 31.118, df = 188, <b>p-value</b> < 2.2e-16<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>0.8884944 0.9355818<br>sample estimates:<br><b>cor</b><br>0.9151051</td><td>Spearman's rank correlation rho<br>data: Od533M_SD$Ca and Od533M_SD$Mg<br>S = 236192, <b>p-value</b> < 2.2e-16<br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br><b>rho</b><br>0.7933822</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] 0.7510065</td><td></td></tr></table>

<figure><img src="image_142.png" /></figure>

• Ca vs P

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD$Ca and Od533M_SD$P<br>t = 113.46, df = 188, <b>p-value</b> < 2.2e-16<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>0.9903906 0.9945722<br>sample estimates:<br><b>cor</b><br>0.9927769</td><td>Spearman's rank correlation rho<br>data: Od533M_SD$Ca and Od533M_SD$P<br>S = 36556, <b>p-value</b> < 2.2e-16<br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br><b>rho</b><br>0.9680213</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] 0.9609519</td><td></td></tr></table>
Classical cor = 0.99 Robust cor = 0.96

<figure><img src="image_143.png" /></figure>

• Cu vs Fe

<table><thead><tr><th></th><th>Pearson's product-moment correlation</th><th>Spearman's rank correlation rho</th></tr></thead><tbody><tr><td>Classical test</td><td>data: Od533M_SD$Cu and Od533M_SD$Fe<br/>t = -0.99885, df = 188, p-value = 0.3192<br/>alternative hypothesis: true correlation is not equal to 0<br/>95 percent confidence interval:<br/>-0.21280835 0.07042566<br/>sample estimates:<br/>cor<br/>-0.07265607</td><td>data: Od533M_SD$Cu and<br/>Od533M_SD$Fe<br/>S = 1199798, p-value = 0.4967<br/>alternative hypothesis: true rho is not<br/>equal to 0<br/>sample estimates:<br/>rho<br/>-0.04956807</td></tr><tr><td>MCD<br/>(α=0.05;<br/>quant=0.8)</td><td>$cor.rob<br/>[1] -0.1037514</td><td></td></tr></tbody></table>

Classical cor = -0.07 Robust cor = -0.1

<figure><img src="image_144.png" /></figure>
## Mg vs Fe

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD$Mg and Od533M_SD$Fe<br>t = 8.243, df = 188, <b>p-value</b> = <b>2.823e-14</b><br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>0.4024041 0.6126594<br>sample estimates:<br><b>cor</b><br><b>0.5152425</b><br><br>$cor.rob<br>[1] 0.2092387</td><td>Spearman's rank correlation rho<br>data: Od533M_SD$Mg and Od533M_SD$Fe<br>S = 717378, <b>p-value</b> = <b>1.513e-07</b><br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br><b>rho</b><br><b>0.3724468</b></td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td></td><td></td></tr></table>

Classical cor = 0.52 Robust cor = 0.21

<figure><img src="image_145.png" /></figure>

## Cu vs Mg

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD$Mg and Od533M_SD$Cu<br>t = -3.5432, df = 188, <b>p-value</b> = <b>0.0004986</b><br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>-0.3790493 -0.1118258<br>sample estimates:<br><b>cor</b><br><b>-0.2501963</b><br><br>$cor.rob<br>[1] 0.08609909</td><td>Spearman's rank correlation rho<br>data: Od533M_SD$Mg and Od533M_SD$Cu<br>S = 1249146, <b>p-value</b> = <b>0.203</b><br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br><b>rho</b><br><b>-0.09273708</b></td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td></td><td></td></tr></table>
Classical cor = -0.25 Robust cor = 0.09

<figure><img src="image_146.png" /></figure>

* As vs Hg, Pb vs Hg (no Hg at all). => Not Applicable.

* Pb vs As

Whole secondary dentinee thickness:

<table><thead><tr><th></th><th>Pearson's product-moment correlation</th><th>Spearman's rank correlation rho</th></tr></thead><tbody><tr><td>Classical test</td><td>data: Od533M_SD$As and Od533M_SD$Pb<br/>t = -0.57847, df = 188, <b>p-value = 0.5636</b><br/>alternative hypothesis: true correlation is not equal to 0<br/>95 percent confidence interval:<br/>-0.1834048 0.1008063<br/>sample estimates:<br/><b>cor</b><br/>-0.04215196</td><td>data: Od533M_SD$As and<br/>Od533M_SD$Pb<br/>S = 1228634, <b>p-value = 0.3048</b><br/>alternative hypothesis: true rho is not<br/>equal to 0<br/>sample estimates:<br/><b>rho</b><br/>-0.07479344</td></tr><tr><td>MCD<br/>(α=0.05;<br/>quant=0.8)</td><td>$cor rob<br/>[1] -0.05585069</td><td></td></tr></tbody></table>

Classical cor = -0.04 Robust cor = -0.06

<figure><img src="image_147.png" /></figure>
Removing 110 µm of Pb-enriched secondary dentinee surface:

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD_wSDS$As and Od533M_SD_wSDS$Pb<br>t = -0.79052, df = 135, p-value = 0.4306<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>-0.2329440 0.1009847<br>sample estimates:<br>cor<br>-0.0678805</td><td>Spearman's rank correlation rho<br>data: Od533M_SD_wSDS$As and Od533M_SD_wSDS$Pb<br>S = 490286, p-value = 0.09296<br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br>rho<br>-0.1440952</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] -0.1582813</td><td></td></tr></table>

$$ \text{Classical cor} = -0.07 \quad \text{Robust cor} = -0.16 $$

<figure><img src="image_148.png" /></figure>

As

• Sb vs Sn

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD$Sn and Od533M_SD$Sb<br>t = -3.4518, df = 188, p-value = 0.0006878<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>-0.3735037 -0.1054417<br>sample estimates:<br>cor<br>-0.2441307</td><td>Spearman's rank correlation rho<br>data: Od533M_SD$Sn and Od533M_SD$Sb<br>S = 1315916, p-value = 0.03746<br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br>rho<br>-0.1511466</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] 0.023168</td><td></td></tr></table>
Classical cor = -0.24 Robust cor = 0.02

<figure><img src="image_149.png" /></figure>

• Pb vs Sb

Whole secondary dentinee thickness:

<table><thead><tr><th></th><th>Pearson's product-moment correlation</th><th>Spearman's rank correlation rho</th></tr></thead><tbody><tr><td>Classical test</td><td><p>data: Od533M_SD$Sb and Od533M_SD$Pb</p><p>t = -0.93918, df = 188, <strong>p-value = 0.3488</strong></p><p>alternative hypothesis: true correlation is not equal to 0</p><p>95 percent confidence interval:</p><p>-0.20866014 0.07474378</p><p>sample estimates:</p><table><tr><td>cor</td><td>$cor rob</td></tr><tr><td>-0.06833665</td><td>[1] 0.03371059</td></tr></table></td><td><p>data: Od533M_SD$Sb and Od533M_SD$Pb</p><p>S = 1110492, <strong>p-value = 0.6955</strong></p><p>alternative hypothesis: true rho is not equal to 0</p><p>sample estimates:</p><table><tr><td>rho</td><td>0.02855568</td></tr></table></td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td></td><td></td></tr></tbody></table>

Classical cor = -0.07 Robust cor = 0.03

<figure><img src="image_150.png" /></figure>
Removing 110 µm of Pb-enriched secondary dentinee surface:

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD_wSDS$Sb and Od533M_SD_wSDS$Pb<br>t = 1.284, df = 135, p-value = 0.2013<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>-0.05896091 0.27253560<br>sample estimates:<br>cor<br>0.1098408</td><td>Spearman's rank correlation rho<br>data: Od533M_SD_wSDS$Sb and Od533M_SD_wSDS$Pb<br>S = 356020, p-value = 0.04817<br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br>rho<br>0.169218</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] 0.340878</td><td></td></tr></table>

Classical cor = 0.11 Robust cor = 0.34

<figure><img src="image_151.png" /></figure>

• Pb vs Sn

Whole secondary dentinee thickness:

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD$Sn and Od533M_SD$Pb<br>t = 2.8353, df = 188, p-value = 0.005079<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>0.06193476 0.33519342<br>sample estimates:<br>cor<br>0.2025027</td><td>Spearman's rank correlation rho<br>data: Od533M_SD$Sn and Od533M_SD$Pb<br>S = 805144, p-value = 3.737e-05<br>alternative hypothesis: true rho is not equal to 0<br>sample estimates:<br>rho<br>0.2956702</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] 0.424453</td><td></td></tr></table>
<figure><img src="image_152.png" /></figure>

Removing 110 µm of Pb-enriched secondary dentinee surface:

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD_wSDS$Sn and<br>Od533M_SD_wSDS$Pb<br>t = 1.5529, df = 135, p-value = 0.1228<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>-0.0360418 0.2936653<br>sample estimates:<br>cor<br>0.1324745</td><td>Spearman's rank correlation rho<br>data: Od533M_SD_wSDS$Sn and<br>Od533M_SD_wSDS$Pb<br>S = 304920, p-value = 0.0006611<br>alternative hypothesis: true rho is not<br>equal to 0<br>sample estimates:<br>rho<br>0.2884612</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] 0.3515933</td><td></td></tr></table>

<figure><img src="image_153.png" /></figure>
• Br vs Ba

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD$Ba and Od533M_SD$Br<br>t = -1.6732, df = 188, p-value = 0.09595<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>-0.2590202 0.0215923<br>sample estimates:<br>cor<br>-0.1211334</td><td>Spearman's rank correlation rho<br>data: Od533M_SD$Ba and<br>Od533M_SD$Br<br>S = 1364608, p-value = 0.007479<br>alternative hypothesis: true rho is not<br>equal to 0<br>sample estimates:<br>rho<br>-0.1937418</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] -0.3389472</td><td></td></tr></table>

Classical cor = -0.12 Robust cor = -0.34

<figure><img src="image_154.png" /></figure>

• Br vs Sr

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD$Sr and Od533M_SD$Br<br>t = 0.19459, df = 188, p-value = 0.8459<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>-0.1284221 0.1562284<br>sample estimates:<br>cor<br>0.01419062</td><td>Spearman's rank correlation rho<br>data: Od533M_SD$Sr and<br>Od533M_SD$Br<br>S = 1275574, p-value = 0.1114<br>alternative hypothesis: true rho is not<br>equal to 0<br>sample estimates:<br>rho<br>-0.115856</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] -0.2620026</td><td></td></tr></table>
Classical cor = 0.01 Robust cor = -0.26

<figure><img src="image_155.png" /></figure>

• Br vs Zn

<table><thead><tr><th></th><th>Pearson's product-moment correlation</th><th>Spearman's rank correlation rho</th></tr></thead><tbody><tr><td>Classical test</td><td>data: Od533M_SD$Zn and Od533M_SD$Br<br/>t = -1.6138, df = 188, p-value = 0.1083<br/>alternative hypothesis: true correlation is not equal to 0<br/>95 percent confidence interval:<br/>-0.25499849 0.02589603<br/>sample estimates:<br/>cor<br/>-0.1168882</td><td>data: Od533M_SD$Zn and Od533M_SD$Br<br/>S = 1232840, p-value = 0.2816<br/>alternative hypothesis: true rho is not equal to 0<br/>sample estimates:<br/>rho<br/>-0.0784728</td></tr><tr><td>MCD<br/>(α=0.05;<br/>quant=0.8)</td><td>$cor.rob<br/>[1] -0.08039107</td><td></td></tr></tbody></table>

Classical cor = -0.12 Robust cor = -0.08

<figure><img src="image_156.png" /></figure>
• Br vs Ca

<table><tr><td>Classical test</td><td>Pearson's product-moment correlation<br>data: Od533M_SD$Ca and Od533M_SD$Br<br>t = 0.59652, df = 188, p-value = 0.5515<br>alternative hypothesis: true correlation is not equal to 0<br>95 percent confidence interval:<br>-0.09950427 0.18467540<br>sample estimates:<br>cor<br>0.04346472</td><td>Spearman's rank correlation rho<br>data: Od533M_SD$Ca and<br>Od533M_SD$Br<br>S = 1193966, p-value = 0.5421<br>alternative hypothesis: true rho is not<br>equal to 0<br>sample estimates:<br>rho<br>-0.04446631</td></tr><tr><td>MCD<br>(α=0.05;<br>quant=0.8)</td><td>$cor.rob<br>[1] -0.2620026</td><td></td></tr></table>

Classical cor = 0.01 Robust cor = -0.26

<figure><img src="image_157.png" /></figure>
File S2

Synchrotron Fluorescence (SXRF) results

Using SXRF and LA-ICP-TOFMS to explore evidence of treatment and physiological responses to leprosy in medieval Denmark

Biology

Anastasia Brozou, Marcello A. Mannino, Stijn J.M. Van Malderen, Jan Garrevoet, Eric Pubert, Benjamin T. Fuller, M. Christopher Dean, Thomas Colard, Frédéric Santos, Niels Lynnerup, Jesper L. Boldsen, Marie Louise Jørkov, Andrei Dorian Soficaru, Laszlo Vincze, Adeline Le Cabec

Corresponding author:

Adeline Le Cabec

E-mail: adeline.le-cabec@u-bordeaux.fr
## Data reconstruction

- Raw data were fitted and calibrated.

- The calculation takes into account the **average thickness of the tooth section** measured by subtracting the thickness of the glass slide from {tooth section + epoxy bond ~negligible thickness + glass slide}.

- The **background noise has been subtracted** from the sample for each element.

In the next slides:

- "Scanning": actual areas scanned.

- Images reported in this ppt are "Mass diffraction", in mg.kg⁻¹ (ppm).

- It is also possible to report "areal density", in g.cm⁻³

- To save space, the elemental maps of some teeth may have been rotated by 90°.

- Maps are displayed using the "Gistheat" colormap.

- To enhance the banding/stress pattern while reducing overall noise, a 2D Gaussian filter was applied to the datasets. The kernel size (=strength of the filter) used is indicated for x and y. This will induce a slight smoothing of any curve generated from a transect. The curve may be saved from the same transect on the unfiltered dataset.

- To improve the visibility of distribution patterns, the contrast is adjusted on the maps, thus not displaying the full range of concentrations recorded in the scan. Numbers cited in the text have been directly measured on the scans, with the full range of concentrations.
## K emission lines.

- For elements which Kα < 17 keV, the detectors capture the K emission lines within the remitted fluorescent light: Ca, Zn, Sr, Cu, Fe, Mn.

- Data are fitted and calibrated, and were processed (open .nxs, colormap, 2D Gauss filter) in HDIP.

## L emission lines.

- For elements which Kα > 17 keV, the detectors only capture the L emission lines within the remitted fluorescent light: Pb and Ba.

- For these elements, data were NOT calibrated.

- For each element, the 32 bit images from Detector 0 and Detector 2 were added in Image J (Process> Image Calculator), and then filtered using a Gaussian blur (Process> Filters> Gaussian blur) with a kernel size of 0.7-0.9.
Romania – R1386 LRM2

<figure><img src="image_158.png" /></figure>

36 yrs. 1890 – 1926 CE

Blacksmith deceased in Colentina Hospital (Bucharest)

Average tooth section thickness (µm): 112.5

<figure><img src="image_159.png" /></figure>

<figure><img src="image_160.png" /></figure>

<figure><img src="image_161.png" /></figure>

<figure><img src="image_162.png" /></figure>

<figure><img src="image_163.png" /></figure>

<figure><img src="image_164.png" /></figure>

<figure><img src="image_165.png" /></figure>

Distal

<figure><img src="image_166.png" /></figure>

Mesial

124 µm

123 µm

110 µm

102 µm

108 µm

109 µm

113 µm

111 µm
<figure><img src="image_167.png" /></figure>
<figure><img src="image_168.png" /><figcaption>Sr K</figcaption></figure>

<figure><img src="image_169.png" /><figcaption>Zn K</figcaption></figure>

<figure><img src="image_170.png" /><figcaption>Cu K</figcaption></figure>

<figure><img src="image_171.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_172.png" /><figcaption>Ca K (Optimised for enamel)</figcaption></figure>

<figure><img src="image_173.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_174.png" /></figure>
<figure><img src="image_175.png" /><figcaption>Close-ups for elemental variations in the dentine</figcaption></figure>
R1386 LRM2

Overview at 10 µm

Uncalibrated data (arbitrary units)

Gauss (1x1)

Br K

<figure><img src="image_176.png" /></figure>

Pb L

<figure><img src="image_177.png" /><figcaption>Optimised for cementum and secondary dentine</figcaption></figure>

<figure><img src="image_178.png" /><figcaption>- Optimised for
primary dentine</figcaption></figure>

<caption>- Significant increase
in Pb at mid-root
(~adolescence)</caption>
<figure><img src="image_179.png" /><figcaption>Close-ups for elemental variations in the cementum and secondary dentine</figcaption></figure>
R1386 LRM2

High resolution at 1.5 µm

Gauss (0.8x0.8)

<figure><img src="image_180.png" /><figcaption>Sr K</figcaption></figure>

<figure><img src="image_181.png" /><figcaption>Zn K</figcaption></figure>

<figure><img src="image_182.png" /><figcaption>Cu K</figcaption></figure>

<figure><img src="image_183.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_184.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_185.png" /></figure>
Pb L

Uncalibrated data
(arbitrary units)

<figure><img src="image_186.png" /></figure>

Mn K

<figure><img src="image_187.png" /></figure>
Romania – A1651 LRM1

<figure><img src="image_188.png" /></figure>

Beginning of 20th c.

Average tooth section thickness (µm): 121.75

<figure><img src="image_189.png" /></figure>

<figure><img src="image_190.png" /></figure>

<figure><img src="image_191.png" /></figure>

<figure><img src="image_192.png" /></figure>

<figure><img src="image_193.png" /></figure>

<figure><img src="image_194.png" /></figure>

<figure><img src="image_195.png" /></figure>
<figure><img src="image_196.png" /></figure>

Overview at 10 µm

High resolution at 1.5 µm
in mixed cellular and
acellular cementum
<figure><img src="image_197.png" /></figure>
<figure><img src="image_198.png" /></figure>
A1651 LRM1

Overview at 10 µm

<figure><img src="image_199.png" /><figcaption>Br K</figcaption></figure>

<figure><img src="image_200.png" /></figure>

Uncalibrated data
(arbitrary units)

Gauss (0.7x0.7)
<figure><img src="image_201.png" /></figure>
<figure><img src="image_202.png" /></figure>

<figure><img src="image_203.png" /></figure>

<figure><img src="image_204.png" /></figure>
<figure><img src="image_205.png" /></figure>

Romania – A1651 URC

<figure><img src="image_206.png" /></figure>

Beginning of 20th c.

<figure><img src="image_207.png" /></figure>

<figure><img src="image_208.png" /></figure>

<figure><img src="image_209.png" /></figure>

<figure><img src="image_210.png" /></figure>

<figure><img src="image_211.png" /></figure>

Average tooth section thickness (µm): 86.2

<figure><img src="image_212.png" /></figure>
Overview at 10 µm

High resolution at 1 µm in cellular cementum

<figure><img src="image_213.png" /></figure>
A1651 URC

Overview at 10 µm

Gauss (0.9x0.9)

<figure><img src="image_214.png" /><figcaption>Sr K</figcaption></figure>

<figure><img src="image_215.png" /><figcaption>Zn K</figcaption></figure>

<figure><img src="image_216.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_217.png" /></figure>

<figure><img src="image_218.png" /></figure>

Fe K [mg/kg]

<figure><img src="image_219.png" /><figcaption>Ca K (optimised for dentine for
elemental variations)</figcaption></figure>
<figure><img src="image_220.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_221.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_222.png" /></figure>
A1651 URC

High resolution at 1 µm

Gauss (1x1)

<figure><img src="image_223.png" /></figure>

<figure><img src="image_224.png" /></figure>

<figure><img src="image_225.png" /></figure>

<figure><img src="image_226.png" /></figure>
<figure><img src="image_227.png" /><figcaption>Cu K</figcaption></figure>

<figure><img src="image_228.png" /></figure>
Odense - 533 LLM1

<figure><img src="image_229.png" /></figure>

♀ 25-35 yrs. 1191 - 1269 cal. CE

mesial

<figure><img src="image_230.png" /></figure>

distal

<figure><img src="image_231.png" /></figure>

Root apex 2

<figure><img src="image_232.png" /></figure>

Root apex 1

<figure><img src="image_233.png" /><figcaption>Average tooth section thickness (µm): 104.0</figcaption></figure>

<figure><img src="image_234.png" /></figure>
Overview at 10 µm

<figure><img src="image_235.png" /></figure>
Odense 533 LLM1

Overview at 10 µm

Gauss (0.9x0.9)

<figure><img src="image_236.png" /><figcaption>Sr K</figcaption></figure>

<figure><img src="image_237.png" /><figcaption>Zn K</figcaption></figure>

<figure><img src="image_238.png" /></figure>
<figure><img src="image_239.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_240.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_241.png" /></figure>
Odense 533 LLM1

<figure><img src="image_242.png" /></figure>

High resolution at 1 µm in cellular cementum

<figure><img src="image_243.png" /></figure>

Gauss (1x1)

<figure><img src="image_244.png" /></figure>
<figure><img src="image_245.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_246.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_247.png" /></figure>
Odense 533 LLM1

High resolution at 1 µm in secondary dentine

Gauss (1x1)

<figure><img src="image_248.png" /></figure>
<figure><img src="image_249.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_250.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_251.png" /></figure>
<figure><img src="image_252.png" /></figure>

Odense - 896 LLC

<figure><img src="image_253.png" /></figure>

35-45 yrs. 1183 - 1265 cal. CE

Average tooth section thickness (µm): 99.4

<figure><img src="image_254.png" /></figure>
Overview at 10 µm

<figure><img src="image_255.png" /></figure>
<figure><img src="image_256.png" /></figure>

<figure><img src="image_257.png" /></figure>

<figure><img src="image_258.png" /></figure>
<figure><img src="image_259.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_260.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_261.png" /></figure>
Odense - 896 LLM1

<figure><img src="image_262.png" /></figure>

35-45 yrs. 1183 - 1265 cal. CE

<figure><img src="image_263.png" /><figcaption>Average tooth section thickness (µm): 99.4</figcaption></figure>

<figure><img src="image_264.png" /></figure>
Overview at 10 µm

High resolution at 1.5 µm in mixed
cellular and acellular cementum

2 mm

<figure><img src="image_265.png" /></figure>
Odense 896 LLM1

Ca K

<figure><img src="image_266.png" /></figure>

Overview at 10 µm

Sr K

<figure><img src="image_267.png" /></figure>

Gauss (1x1)

Zn K

<figure><img src="image_268.png" /></figure>
<figure><img src="image_269.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_270.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_271.png" /></figure>
Odense 896 LLM1

High resolution at 1.5 µm

Gauss (1x1)

Ca K

<figure><img src="image_272.png" /></figure>

Sr K

<figure><img src="image_273.png" /></figure>

Zn K

<figure><img src="image_274.png" /></figure>

<figure><img src="image_275.png" /></figure>

<figure><img src="image_276.png" /></figure>
<figure><img src="image_277.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_278.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_279.png" /></figure>
Odense - 914 ULM1

<figure><img src="image_280.png" /></figure>

25-35 yrs. 1459 - 1566 cal. CE

<figure><img src="image_281.png" /></figure>

2 buccal
roots

<figure><img src="image_282.png" /></figure>

distal

<figure><img src="image_283.png" /></figure>

2 buccal
roots

Average tooth section thickness
(µm): 95.9

<figure><img src="image_284.png" /></figure>
<figure><img src="image_285.png" /></figure>

High resolution at 1 µm in cellular cementum

Overview at 10 µm
Odense 914 ULM1

Ca K

<figure><img src="image_286.png" /></figure>

Overview at 10 µm

Sr K

<figure><img src="image_287.png" /></figure>

Gauss (1x1)

Zn K

<figure><img src="image_288.png" /></figure>
<figure><img src="image_289.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_290.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_291.png" /></figure>
Odense 914 ULM1

Br K

2.0 mm

<figure><img src="image_292.png" /></figure>

Overview at 10 µm

Pb L

<figure><img src="image_293.png" /></figure>

Uncalibrated data
(arbitrary units)

Gauss (1x1)
Odense 914 ULM1

<figure><img src="image_294.png" /></figure>

High resolution at 1 µm

<figure><img src="image_295.png" /></figure>

Gauss (0.9x0.9)

<figure><img src="image_296.png" /></figure>
<figure><img src="image_297.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_298.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_299.png" /></figure>
Odense - 1149 URC

<figure><img src="image_300.png" /></figure>

20-30 yrs. 1301 - 1415 cal. CE

<figure><img src="image_301.png" /><figcaption>Average tooth section thickness (µm): 98.0</figcaption></figure>

<figure><img src="image_302.png" /></figure>
Overview at 10 µm

<figure><img src="image_303.png" /></figure>

High resolution at 1 µm in acellular cementum
Odense 1149 URC

Overview at 10 µm

Gauss (1.2x1.2)

<figure><img src="image_304.png" /></figure>
<figure><img src="image_305.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_306.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_307.png" /></figure>
<figure><img src="image_308.png" /><figcaption>Overview at 10 µm</figcaption></figure>

<caption>Uncalibrated data
(arbitrary units)</caption>

<caption>Gauss (1.2x1.2)</caption>
Odense 1149 URC

High resolution at 1 µm in acellular cementum

Gauss (1x1)

<figure><img src="image_309.png" /></figure>
<figure><img src="image_310.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_311.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_312.png" /></figure>
Odense - 1149 ULM1

<figure><img src="image_313.png" /></figure>

20-30 yrs. 1301 - 1415 cal. CE

Average tooth section thickness
(µm): 103.5

<figure><img src="image_314.png" /></figure>

<figure><img src="image_315.png" /></figure>
Scanning

<figure><img src="image_316.png" /></figure>

Odense 1149 ULM1

Overview at 10 µm

Problem of offset when
centering sample

High resolution at 1 µm in
mixed cellular and acellular
cementum
Odense 1149 ULM1

Ca K

<figure><img src="image_317.png" /></figure>

Overview at 10 µm

Sr K

<figure><img src="image_318.png" /></figure>

Gauss (1x1)

Zn K

<figure><img src="image_319.png" /></figure>
<figure><img src="image_320.png" /></figure>

<figure><img src="image_321.png" /></figure>

<figure><img src="image_322.png" /></figure>
Odense 1149 ULM1

Br K

<figure><img src="image_323.png" /></figure>

Overview at 10 µm

Pb L

<figure><img src="image_324.png" /></figure>

Uncalibrated data
(arbitrary units)

Gauss (1x1)
<figure><img src="image_325.png" /><figcaption>High resolution at 1 µm</figcaption></figure>

<caption>Gauss (1.2x1.2)</caption>
Odense 1149 ULM1

High resolution at 1 µm

Gauss (1.2x1.2)

Cu K

<figure><img src="image_326.png" /></figure>

Fe K

<figure><img src="image_327.png" /></figure>

Mn K

<figure><img src="image_328.png" /></figure>
Næstved – 6 ULC

<figure><img src="image_329.png" /></figure>

~20 yrs. mid-13th – mid-16th c. CE

<figure><img src="image_330.png" /><figcaption>Average tooth section thickness (µm): 115.0</figcaption></figure>

<figure><img src="image_331.png" /></figure>
Overview at 10 µm

High resolution at 1 µm in acellular cementum

<figure><img src="image_332.png" /></figure>
<figure><img src="image_333.png" /></figure>
<figure><img src="image_334.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_335.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_336.png" /></figure>
Næstved 6 ULC

Overview at 10 µm

<figure><img src="image_337.png" /></figure>

Uncalibrated data
(arbitrary units)

Gauss (1x1)
<figure><img src="image_338.png" /></figure>

<figure><img src="image_339.png" /></figure>

<figure><img src="image_340.png" /></figure>
<figure><img src="image_341.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_342.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_343.png" /></figure>
<figure><img src="image_344.png" /></figure>

Næstved - 211 URC

<figure><img src="image_345.png" /></figure>

40-45 yrs. 1184 - 1266 cal. CE

Average tooth section thickness (µm): 134.2

<figure><img src="image_346.png" /></figure>
Overview at 10 µm

High resolution at 1 µm

<figure><img src="image_347.png" /></figure>
<figure><img src="image_348.png" /><figcaption>Sr K</figcaption></figure>

<figure><img src="image_349.png" /><figcaption>Zn K</figcaption></figure>

<figure><img src="image_350.png" /></figure>
<figure><img src="image_351.png" /></figure>
<figure><img src="image_352.png" /><figcaption>Pb L</figcaption></figure>

<figure><img src="image_353.png" /></figure>
Næstved 211 URC

High resolution at 1 µm

<figure><img src="image_354.png" /></figure>

Uncalibrated data
(arbitrary units)

Gauss (1x1)
<figure><img src="image_355.png" /><figcaption>Uncalibrated data
(arbitrary units)</figcaption></figure>

<figure><img src="image_356.png" /><figcaption>Gauss (1x1)</figcaption></figure>
<figure><img src="image_357.png" /><figcaption>Pb L</figcaption></figure>

<figure><img src="image_358.png" /></figure>
Næstved - 211 LRM1

<figure><img src="image_359.png" /></figure>

40-45 yrs. 1184 - 1266 cal. CE

<figure><img src="image_360.png" /></figure>

<figure><img src="image_361.png" /></figure>

<figure><img src="image_362.png" /></figure>

<figure><img src="image_363.png" /></figure>

<figure><img src="image_364.png" /></figure>

Average tooth section thickness (µm): 108.3
<figure><img src="image_365.png" /></figure>

Overview at 10 µm

High resolution at 1.5 µm in
acellular cementum
<figure><img src="image_366.png" /><figcaption>Sr K</figcaption></figure>

<figure><img src="image_367.png" /><figcaption>Zn K</figcaption></figure>

<figure><img src="image_368.png" /></figure>
<figure><img src="image_369.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_370.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_371.png" /></figure>
Næstved 211 LRM1

Overview at 10 µm

Gauss (1x1)

Uncalibrated data
(arbitrary units)

<figure><img src="image_372.png" /><figcaption>Pb L</figcaption></figure>

<figure><img src="image_373.png" /></figure>
Næstved 211 LRM1

High resolution at 1.5 µm

Gauss (1x1)

<figure><img src="image_374.png" /></figure>
<figure><img src="image_375.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_376.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_377.png" /></figure>
Næstved - 268 LLM1

<figure><img src="image_378.png" /></figure>

30-40 yrs. 1441 - 1522 cal. CE

<figure><img src="image_379.png" /></figure>

<figure><img src="image_380.png" /></figure>

<figure><img src="image_381.png" /></figure>

<figure><img src="image_382.png" /></figure>

<figure><img src="image_383.png" /></figure>

Average tooth section thickness (µm): 102.0
Overview at 10 µm

<figure><img src="image_384.png" /></figure>

High resolution at 1.5 µm in cellular cementum
<figure><img src="image_385.png" /><figcaption>Sr K</figcaption></figure>

<figure><img src="image_386.png" /><figcaption>Zn K</figcaption></figure>

<figure><img src="image_387.png" /></figure>
<figure><img src="image_388.png" /></figure>

<figure><img src="image_389.png" /></figure>

<figure><img src="image_390.png" /></figure>
Næstved 268 LLM1

High resolution at 1 µm

Gauss (1x1)

<figure><img src="image_391.png" /></figure>
Næstved 268 LLM1

Cu K

<figure><img src="image_392.png" /></figure>

Fe K

<figure><img src="image_393.png" /></figure>

High resolution at 1 µm

Mn K

<figure><img src="image_394.png" /></figure>

Gauss (1x1)

Pb L

<figure><img src="image_395.png" /></figure>
Næstved – 305 LLC

<figure><img src="image_396.png" /></figure>

30-35 yrs. mid-13th – mid-16th c. CE

<figure><img src="image_397.png" /></figure>

<figure><img src="image_398.png" /></figure>

Average tooth section thickness (µm): 119.0
Overview at 10 µm

<figure><img src="image_399.png" /></figure>
<figure><img src="image_400.png" /><figcaption>Sr K</figcaption></figure>

<figure><img src="image_401.png" /><figcaption>Zn K</figcaption></figure>

<figure><img src="image_402.png" /></figure>
<figure><img src="image_403.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_404.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_405.png" /></figure>
Uncalibrated data
(arbitrary units)

<figure><img src="image_406.png" /><figcaption>Pb L</figcaption></figure>

<figure><img src="image_407.png" /></figure>
Næstved – 305 LRM1

<figure><img src="image_408.png" /></figure>

30-35 yrs. mid-13th – mid-16th c. CE

<figure><img src="image_409.png" /></figure>

<figure><img src="image_410.png" /></figure>

<figure><img src="image_411.png" /></figure>

Average tooth section thickness (µm): 117.6
<figure><img src="image_412.png" /></figure>
Næstved 305 LRM1

Overview at 10 µm

Gauss (1x1)

<figure><img src="image_413.png" /><figcaption>Sr K</figcaption></figure>

<figure><img src="image_414.png" /><figcaption>Zn K</figcaption></figure>

<figure><img src="image_415.png" /></figure>
<figure><img src="image_416.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_417.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_418.png" /></figure>
Næstved 305 LRM1

Pb L

<figure><img src="image_419.png" /></figure>

Overview at 10 µm

Br K

<figure><img src="image_420.png" /></figure>

Uncalibrated data
(arbitrary units)

Gauss (1x1)
Næstved 305 LRM1

<figure><img src="image_421.png" /></figure>

High resolution at 1.5 µm

<figure><img src="image_422.png" /></figure>

Gauss (1x1)

<figure><img src="image_423.png" /></figure>
Næstved 305 LRM1

High resolution at 1.5 µm

Gauss (1x1)

<figure><img src="image_424.png" /><figcaption>Fe K</figcaption></figure>

<figure><img src="image_425.png" /><figcaption>Mn K</figcaption></figure>

<figure><img src="image_426.png" /></figure>
File S3

Laser Ablation (LA-ICP-TOFMS) results

# Using SXRF and LA-ICP-TOFMS to explore evidence of treatment and physiological responses to leprosy in medieval Denmark

Biology

Anastasia Brozou, Marcello A. Mannino, Stijn J.M. Van Malderen, Jan Garrevoet, Eric Pubert, Benjamin T. Fuller, M. Christopher Dean, Thomas Colard, Frédéric Santos, Niels Lynnerup, Jesper L. Boldsen, Marie Louise Jørkov, Andrei Dorian Soficaru, Laszlo Vincze, Adeline Le Cabec

Corresponding author:

Adeline Le Cabec

E-mail: adeline.le-cabec@u-bordeaux.fr
Teeth with the best SXRF signal in cellular cementum.

Odense 533 LLM1:

The cellular cementum and the secondary dentine are also imaged with SXRF.

The acellular cementum is scanned here for comparison.

<figure><img src="image_427.png" /></figure>

Næstved 211 URC

<figure><img src="image_428.png" /></figure>
# Naestved 211 URC –
Cellular Cementum

Gauss 0.8 x 0.8

<figure><img src="image_429.png" /></figure>

<figure><img src="image_430.png" /></figure>

<figure><img src="image_431.png" /></figure>

<figure><img src="image_432.png" /></figure>

Air

Root surface

<figure><img src="image_433.png" /></figure>

<figure><img src="image_434.png" /></figure>
Næstved 211C - Cellular Cementum

<figure><img src="image_435.png" /><figcaption>²³Na</figcaption></figure>

<figure><img src="image_436.png" /><figcaption>⁶³Cu</figcaption></figure>

<figure><img src="image_437.png" /></figure>

<figure><img src="image_438.png" /></figure>

<figure><img src="image_439.png" /></figure>
Næstved 211C – Cellular Cementum

75As

<figure><img src="image_440.png" /></figure>

55Mn

<figure><img src="image_441.png" /></figure>

202Hg

No detectable
mercury

<figure><img src="image_442.png" /></figure>

208Pb

<figure><img src="image_443.png" /></figure>
Odense 533 LLM1 –
Cellular Cementum

<figure><img src="image_444.png" /></figure>

Towards root apex

$^{44}$Ca

<figure><img src="image_445.png" /></figure>

$^{31}$P

<figure><img src="image_446.png" /></figure>

Gauss 0.9 x 0.9
Odense 533M – Cellular Cementum

$^{24}$Mg

<figure><img src="image_447.png" /></figure>

$^{23}$Na

<figure><img src="image_448.png" /></figure>

$^{66}$Zn

<figure><img src="image_449.png" /></figure>

$^{138}$Ba

$^{138}$Ba + [ppm]

<figure><img src="image_450.png" /></figure>
Odense 533M – Cellular Cementum

$^{63}$Cu

<figure><img src="image_451.png" /></figure>

$^{56}$Fe

<figure><img src="image_452.png" /></figure>

$^{88}$Sr

<figure><img src="image_453.png" /></figure>
# Odense 533M – Cellular Cementum

No detectable mercury or arsenic

75As

200 µm

<figure><img src="image_454.png" /></figure>

202Hg

200 µm

<figure><img src="image_455.png" /></figure>

208Pb

<figure><img src="image_456.png" /></figure>

208Pb adjusted

<figure><img src="image_457.png" /></figure>

55Mn

<figure><img src="image_458.png" /></figure>
Odense 533 LLM1 –
Acellular Cementum

Gauss 0.8 x 0.8

<figure><img src="image_459.png" /></figure>

<figure><img src="image_460.png" /></figure>
Odense 533M – Acellular Cementum

$^{24}$Mg

<figure><img src="image_461.png" /></figure>

$^{23}$Na

<figure><img src="image_462.png" /></figure>

$^{66}$Zn

<figure><img src="image_463.png" /></figure>

$^{138}$Ba

<figure><img src="image_464.png" /></figure>
Odense 533M – Acellular Cementum

$^{63}_{209}\text{Cu}$

<figure><img src="image_465.png" /></figure>

$^{56}_{29}\text{Fe}$

<figure><img src="image_466.png" /></figure>

$^{88}_{208}\text{Sr}$

<figure><img src="image_467.png" /></figure>

$^{55}_{25}\text{Mn}$

<figure><img src="image_468.png" /></figure>
Odense 533M – Acellular Cementum

$^{75}$As

<figure><img src="image_469.png" /></figure>

$^{202}$Hg

<figure><img src="image_470.png" /></figure>

No detectable mercury

$^{208}$Pb

<figure><img src="image_471.png" /></figure>
Odense 533 LLM1 –
Secondary Dentine

Gauss 0.8 x 0.8

<figure><img src="image_472.png" /></figure>
Odense 533M – Secondary Dentine

$^{66}$Zn

<figure><img src="image_473.png" /></figure>

$^{23}$Na

<figure><img src="image_474.png" /></figure>

$^{138}$Ba

<figure><img src="image_475.png" /></figure>
Odense 533M – Secondary Dentine

$^{88}$Sr

<figure><img src="image_476.png" /></figure>

$^{56}$Fe

<figure><img src="image_477.png" /></figure>

$^{24}$Mg

<figure><img src="image_478.png" /></figure>

<figure><img src="image_479.png" /></figure>
Odense 533M – Secondary Dentine

$^{63}$Cu

<figure><img src="image_480.png" /></figure>

$^{75}$As

<figure><img src="image_481.png" /></figure>
Odense 533M – Secondary Dentine

$^{202}$Hg

<figure><img src="image_482.png" /></figure>

No detectable mercury

$^{208}$Pb

<figure><img src="image_483.png" /></figure>

$^{55}$Mn

<figure><img src="image_484.png" /></figure>
<table><caption>Table S1. List of individuals and teeth included in the study from the two medieval Danish leprosy sites (Odense and Næstved).</caption><thead><tr><th>Site</th><th>Gr. Nr.</th><th>Teeth</th><th>Rounding of the edge of nasal aperture right</th><th>Rounding of the edge of nasal aperture left</th><th>Atrophy of the anterior nasal spine</th><th>Recession of the alveolar process of the premaxilla right</th><th>Recession of the alveolar process of the premaxilla left</th><th>Porosity / perforation of the palate right</th><th>Porosity / perforation of the palate left</th><th>Bones of hands</th><th>Lower legs</th><th>Bones of feet</th></tr></thead><tbody><tr><td>Odense</td><td>265</td><td>LRC, ULM1</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>1</td><td>1</td><td>volar groove in two proximal phalanges</td><td>no indication</td><td>no indication at present elements</td></tr><tr><td>Odense</td><td>533</td><td>LLC, LLM1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>no indication at present elements</td><td>tibiae: lamellar bone at areas of all shaft; fibulae: dense lamellar bone at medial distal shaft</td><td>no indication at present elements</td></tr><tr><td>Odense</td><td>896</td><td>LLC, LLM1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>-</td><td>-</td><td>no indication at present elements</td><td>not present</td><td>no indication at present elements</td></tr><tr><td>Odense</td><td>914</td><td>LRC, ULM1</td><td>1</td><td>1</td><td>1</td><td>0</td><td>0</td><td>0</td><td>0</td><td>no indication at present elements</td><td>not present</td><td>not present</td></tr><tr><td>Odense</td><td>936</td><td>LLC, ULM1</td><td>1</td><td>0</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>volar groove in three proximal phalanges</td><td>not present</td><td>not present</td></tr><tr><td>Odense</td><td>1149</td><td>URC, ULM1</td><td>1</td><td>1</td><td>1</td><td>0</td><td>0</td><td>1</td><td>1</td><td>volar groove in two proximal phalanges</td><td>no indication</td><td>no indication at present elements</td></tr><tr><td>Næstved</td><td>6</td><td>ULC, URM1</td><td>1</td><td>1</td><td>0</td><td>0</td><td>0</td><td>1</td><td>1</td><td>non observable</td><td>slight porosity at the shaft of tibiae</td><td>no indication at present elements</td></tr><tr><td>Næstved</td><td>110</td><td>URC, LRM1</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>1</td><td>1</td><td>no indication at present elements</td><td>fibulae: porosity and lamellar bone at mid shaft and woven bone at distal shaft (laterally); left tibia: woven and lamellar bone at mid shaft and woven at ends of diaphysis</td><td>diaphyseal remodelling of one metatarsal, bone destruction at one tarsal fragment (calcaneus?)</td></tr><tr><td>Næstved</td><td>206</td><td>URC, ULM1</td><td>0</td><td>0</td><td>1</td><td>0</td><td>0</td><td>1</td><td>1</td><td>no indication at present elements</td><td>tibiae and fibulae: dense lamellar bone at all shaft; fibulae: bony outgrowths at the shaft</td><td>woven and lamellar bone at some metatarsals and phalanges (among others: 1<sup>st</sup> metatarsals and proximal and distal 1<sup>st</sup> phalanges)</td></tr><tr><td>Næstved</td><td>211</td><td>URC, LRM1</td><td>0</td><td>1</td><td>2</td><td>0</td><td>0</td><td>1</td><td>1</td><td>no indication at present elements</td><td>tibiae and femora: lamellar bone at all shaft</td><td>5<sup>th</sup> left metatarsal: woven at inferior mid shaft</td></tr><tr><td>Næstved</td><td>268</td><td>LRC, LLM1</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>1</td><td>1</td><td>proximal phalanx: pointed distal end (?) (post mortem damage in the area, but medullary cavity seems reduced)</td><td>left tibia: lamellar bone at all sides of shaft (more dense at the proximal inferior and at the mid and distal lateral sides); right tibia: woven bone at all sides of shaft (at the medial side mixed with lamellar bone, at the proximal inferior very dense); right fibula: dense lamellar at the inferior and medial shaft; left fibula: all shaft dense lamellar bone (shaft seems swollen, no cloaca)</td><td>right calcaneus: bone remodelling (also postmortem damage); left calcaneus: bone remodelling (mix woven and lamellar bone) at all sides of mid and distal parts; 2<sup>nd</sup> right metatarsal: dense woven at the inferior shaft and thinner layer at the superior shaft</td></tr><tr><td>Næstved</td><td>305</td><td>LLC, LRM1</td><td>1</td><td>1</td><td>2</td><td>0</td><td>0</td><td>1</td><td>1</td><td>right: bone remodelling on shaft of metacarpals (mainly 5<sup>th</sup>) and phalanges; left: remodelling on shaft of metacarpals (mainly 4<sup>th</sup>)</td><td>right tibia and fibula: mix of woven and lamellar bone at all shaft; left tibia and fibula: non observable</td><td>non observable</td></tr></tbody></table>

The scoring system for changes on facial bones is provided by Boldsen and Freund (2006, Scandinavian Journal of Forensic Sciences, 2:67-72) and Boldsen (2007, Leprosy in Medieval Denmark – A comprehensive analysis) (Scores: -: No information due to poor preservation of the relevant bone area, 0: Unaffected, 1: Slightly affected, 2: Severely affected).

Abbreviations for teeth are designated as follows: 'L' or 'U' for 'lower' or 'upper'; 'L' or 'R' for 'left' or 'right'; 'C' or 'M' for 'canine' or 'molar'; and finally the tooth position in Arabic numerals. For instance, 'LLM1' represents 'lower left first molar'.
<table><caption>Table S2. Age and sex determination and ¹⁴C dates of the individuals of interest for SXRF and LA-ICP-TOFMS scanning.</caption><thead><tr><th>Site</th><th>Gr. Nr.</th><th>Sex</th><th>Age</th><th>Calibrated age CE (modelled) (2σ; 95.4%)</th><th>SXRF scans</th><th>LA-ICP-TOFMS scans</th></tr></thead><tbody><tr><td>Næstved</td><td>6</td><td>female</td><td>~20</td><td>-</td><td>x</td><td></td></tr><tr><td>Næstved</td><td>305</td><td>male</td><td>30-35</td><td>-</td><td>x</td><td></td></tr><tr><td>Odense</td><td>896</td><td>male</td><td>35-45</td><td>1183 – 1265 [95.4%]</td><td>x</td><td></td></tr><tr><td>Næstved</td><td>211</td><td>female</td><td>40-45</td><td>1184 – 1266 [95.4%]</td><td>x</td><td>x</td></tr><tr><td>Odense</td><td>533</td><td>female</td><td>25-35</td><td>1191 – 1269 [95.4%]</td><td>x</td><td>x</td></tr><tr><td>Odense</td><td>1149</td><td>female</td><td>20-30</td><td>1301 – 1415 [95.4%]</td><td>x</td><td></td></tr><tr><td>Næstved</td><td>268</td><td>male</td><td>30-40</td><td>1441 – 1522 [95.4%]</td><td>x</td><td></td></tr><tr><td>Odense</td><td>914</td><td>female</td><td>25-35</td><td>1459 – 1566 [95.4%]</td><td>x</td><td></td></tr></tbody></table>

<footnote n="14">¹⁴C dates from Brozou et al. 2021, American Journal of Physical Anthropology, doi: 10.1002/ajpa.24339</footnote>
<table><caption>Table S3. Limits of detection (LOD) and of quantitation (LOQ) of the calibrated LA-ICP-TOFMS data.</caption><thead><tr><th></th><th>LOD [ppm]</th><th>LOQ [ppm]</th></tr></thead><tbody><tr><td>[23Na]+</td><td>240</td><td>780</td></tr><tr><td>[24Mg]+</td><td>320</td><td>1070</td></tr><tr><td>[31P]+</td><td>900</td><td>2950</td></tr><tr><td>[44Ca]+</td><td>-</td><td>-</td></tr><tr><td>[55Mn]+</td><td>50</td><td>180</td></tr><tr><td>[56Fe]+</td><td>50</td><td>170</td></tr><tr><td>[63Cu]+</td><td>110</td><td>360</td></tr><tr><td>[66Zn]+</td><td>330</td><td>1110</td></tr><tr><td>[75As]+</td><td>380</td><td>1250</td></tr><tr><td>[81Br]+</td><td>180</td><td>610</td></tr><tr><td>[88Sr]+</td><td>30</td><td>90</td></tr><tr><td>[138Ba]+</td><td>-</td><td>-</td></tr><tr><td>[202Hg]+</td><td>-</td><td>-</td></tr><tr><td>[208Pb]+</td><td>5</td><td>16</td></tr></tbody></table>

no Ca in the reference, so values cannot be calculated.

no Ba in the reference, so values cannot be calculated.

no Hg in the reference, so values cannot be calculated.

Values are rounded to the nearest ten. LOQ values are shaded in blue as these are the values used to assess the significance of concentrations observed in the data.
<table>
  <tbody>
    <tr>
      <td>214.85</td>
      <td>2.98446</td>
      <td>80.65</td>
    </tr>
    <tr>
      <td>219.10</td>
      <td>2.87808</td>
      <td>98.67</td>
    </tr>
    <tr>
      <td>221.23</td>
      <td>2.82733</td>
      <td>117.441</td>
    </tr>
    <tr>
      <td>222.58</td>
      <td>2.71926</td>
      <td>114.33</td>
    </tr>
    <tr>
      <td>224.71</td>
      <td>2.68622</td>
      <td>109.922</td>
    </tr>
    <tr>
      <td>225.48</td>
      <td>2.71926</td>
      <td>116.46</td>
    </tr>
    <tr>
      <td>226.11</td>
      <td>2.68622</td>
      <td>118.32</td>
    </tr>
    <tr>
      <td>227.76</td>
      <td>2.90323</td>
      <td>105.35</td>
    </tr>
    <tr>
      <td>228.24</td>
      <td>2.90323</td>
      <td>105.35</td>
    </tr>
    <tr>
      <td>229.09</td>
      <td>2.90323</td>
      <td>105.35</td>
    </tr>
    <tr>
      <td>231.86</td>
      <td>2.87011</td>
      <td>120.59</td>
    </tr>
    <tr>
      <td>233.99</td>
      <td>2.76646</td>
      <td>117.656</td>
    </tr>
    <tr>
      <td>236.12</td>
      <td>2.72846</td>
      <td>112.941</td>
    </tr>
    <tr>
      <td>238.28</td>
      <td>2.72846</td>
      <td>114.915</td>
    </tr>
    <tr>
      <td>239.44</td>
      <td>2.72846</td>
      <td>110.919</td>
    </tr>
    <tr>
      <td>240.37</td>
      <td>2.75924</td>
      <td>62.43</td>
    </tr>
    <tr>
      <td>242.50</td>
      <td>2.74411</td>
      <td>60.57</td>
    </tr>
    <tr>
      <td>244.63</td>
      <td>2.78933</td>
      <td>118.90</td>
    </tr>
    <tr>
      <td>246.75</td>
      <td>2.85164</td>
      <td>27.08</td>
    </tr>
    <tr>
      <td>248.88</td>
      <td>2.85164</td>
      <td>56.29</td>
    </tr>
    <tr>
      <td>250.11</td>
      <td>2.81840</td>
      <td>15.59</td>
    </tr>
    <tr>
      <td>251.33</td>
      <td>2.77907</td>
      <td>114.13</td>
    </tr>
    <tr>
      <td>252.56</td>
      <td>2.90505</td>
      <td>62.19</td>
    </tr>
    <tr>
      <td>253.79</td>
      <td>3.00000</td>
      <td>10.50</td>
    </tr>
    <tr>
      <td>255.92</td>
      <td>2.95806</td>
      <td>42.96</td>
    </tr>
    <tr>
      <td>261.64</td>
      <td>2.87480</td>
      <td>37.79</td>
    </tr>
    <tr>
      <td>263.77</td>
      <td>2.91081</td>
      <td>43.49</td>
    </tr>
    <tr>
      <td>265.90</td>
      <td>2.89266</td>
      <td>38.68</td>
    </tr>
    <tr>
      <td>268.02</td>
      <td>2.84212</td>
      <td>53.65</td>
    </tr>
    <tr>
      <td>270.15</td>
      <td>2.85091</td>
      <td>63.28</td>
    </tr>
    <tr>
      <td>272.28</td>
      <td>2.99450</td>
      <td>107.96</td>
    </tr>
    <tr>
      <td>274.41</td>
      <td>3.14037</td>
      <td>68.52</td>
    </tr>
    <tr>
      <td>276.53</td>
      <td>3.20037</td>
      <td>111.843</td>
    </tr>
    <tr>
      <td>278.86</td>
      <td>3.17850</td>
      <td>116.554</td>
    </tr>
    <tr>
      <td>279.78</td>
      <td>3.20037</td>
      <td>116.554</td>
    </tr>
    <tr>
      <td>281.00</td>
      <td>3.17850</td>
      <td>116.554</td>
    </tr>
    <tr>
      <td>282.89</td>
      <td>3.13201</td>
      <td>23.45</td>
    </tr>
    <tr>
      <td>291.42</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>293.15</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>294.88</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>296.02</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>297.79</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>300.00</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>302.00</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>304.88</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>306.14</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>308.35</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>310.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>312.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>314.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>316.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>318.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>320.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>322.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>324.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>326.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>328.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>330.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>332.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>334.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>336.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>338.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>340.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>342.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>344.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>346.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>348.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>350.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>352.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>354.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>356.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>358.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>360.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>362.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>364.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>366.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>368.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>370.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>372.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>374.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>376.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>378.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>380.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>382.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>384.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>386.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>388.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>390.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>392.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>394.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>396.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>398.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>400.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>402.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>404.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>406.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>408.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>410.55</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>412.67</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>414.80</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>416.93</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>419.18</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>421.19</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>423.31</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>425.44</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>427.56</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>429.69</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>431.82</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>433.94</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>436.07</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>438.20</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>440.33</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>442.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
  </tbody>
</table>

<table>
  <tbody>
    <tr>
      <td>214.85</td>
      <td>2.98446</td>
      <td>80.65</td>
    </tr>
    <tr>
      <td>219.10</td>
      <td>2.87808</td>
      <td>98.67</td>
    </tr>
    <tr>
      <td>221.23</td>
      <td>2.82733</td>
      <td>117.441</td>
    </tr>
    <tr>
      <td>222.58</td>
      <td>2.71926</td>
      <td>114.33</td>
    </tr>
    <tr>
      <td>224.71</td>
      <td>2.68622</td>
      <td>109.922</td>
    </tr>
    <tr>
      <td>225.48</td>
      <td>2.71926</td>
      <td>116.46</td>
    </tr>
    <tr>
      <td>226.11</td>
      <td>2.68622</td>
      <td>118.32</td>
    </tr>
    <tr>
      <td>227.76</td>
      <td>2.90323</td>
      <td>105.35</td>
    </tr>
    <tr>
      <td>228.24</td>
      <td>2.90323</td>
      <td>105.35</td>
    </tr>
    <tr>
      <td>229.09</td>
      <td>2.90323</td>
      <td>105.35</td>
    </tr>
    <tr>
      <td>231.86</td>
      <td>2.87011</td>
      <td>120.59</td>
    </tr>
    <tr>
      <td>233.99</td>
      <td>2.76646</td>
      <td>117.656</td>
    </tr>
    <tr>
      <td>236.12</td>
      <td>2.72846</td>
      <td>112.941</td>
    </tr>
    <tr>
      <td>238.28</td>
      <td>2.72846</td>
      <td>114.915</td>
    </tr>
    <tr>
      <td>239.44</td>
      <td>2.72846</td>
      <td>110.919</td>
    </tr>
    <tr>
      <td>240.37</td>
      <td>2.75924</td>
      <td>62.43</td>
    </tr>
    <tr>
      <td>242.50</td>
      <td>2.74411</td>
      <td>60.57</td>
    </tr>
    <tr>
      <td>244.63</td>
      <td>2.78933</td>
      <td>118.90</td>
    </tr>
    <tr>
      <td>246.75</td>
      <td>2.85164</td>
      <td>27.08</td>
    </tr>
    <tr>
      <td>248.88</td>
      <td>2.85164</td>
      <td>56.29</td>
    </tr>
    <tr>
      <td>250.11</td>
      <td>2.81840</td>
      <td>15.59</td>
    </tr>
    <tr>
      <td>251.33</td>
      <td>2.77907</td>
      <td>114.13</td>
    </tr>
    <tr>
      <td>252.56</td>
      <td>2.90505</td>
      <td>62.19</td>
    </tr>
    <tr>
      <td>253.79</td>
      <td>3.00000</td>
      <td>10.50</td>
    </tr>
    <tr>
      <td>255.92</td>
      <td>2.95806</td>
      <td>42.96</td>
    </tr>
    <tr>
      <td>261.64</td>
      <td>2.87480</td>
      <td>37.79</td>
    </tr>
    <tr>
      <td>263.77</td>
      <td>2.91081</td>
      <td>43.49</td>
    </tr>
    <tr>
      <td>265.90</td>
      <td>2.89266</td>
      <td>38.68</td>
    </tr>
    <tr>
      <td>268.02</td>
      <td>2.84212</td>
      <td>53.65</td>
    </tr>
    <tr>
      <td>270.15</td>
      <td>2.85091</td>
      <td>63.28</td>
    </tr>
    <tr>
      <td>272.28</td>
      <td>2.99450</td>
      <td>107.96</td>
    </tr>
    <tr>
      <td>274.41</td>
      <td>3.14037</td>
      <td>68.52</td>
    </tr>
    <tr>
      <td>276.53</td>
      <td>3.20037</td>
      <td>111.843</td>
    </tr>
    <tr>
      <td>278.86</td>
      <td>3.17850</td>
      <td>116.554</td>
    </tr>
    <tr>
      <td>279.78</td>
      <td>3.20037</td>
      <td>116.554</td>
    </tr>
    <tr>
      <td>281.00</td>
      <td>3.17850</td>
      <td>116.554</td>
    </tr>
    <tr>
      <td>282.89</td>
      <td>3.13201</td>
      <td>23.45</td>
    </tr>
    <tr>
      <td>291.42</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>293.15</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>294.88</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>296.02</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>297.79</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>300.00</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>302.00</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>304.88</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>306.14</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>308.35</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>310.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>312.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>314.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>316.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>318.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>320.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>322.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>324.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>326.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>328.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>330.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>332.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>334.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>336.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>338.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>340.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>342.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>344.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>346.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>348.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>350.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>352.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>354.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>356.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>358.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>360.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>362.40</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>364.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>366.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>368.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>370.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>372.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>374.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>376.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>378.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>380.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>382.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>384.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>386.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>388.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>390.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>392.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>394.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>396.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>398.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>400.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>402.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>404.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>406.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>408.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>410.55</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>412.67</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>414.80</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>416.93</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>419.18</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>421.19</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>423.31</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>425.44</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>427.56</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>429.69</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>431.82</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>433.94</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>436.07</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>438.20</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>440.33</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
    <tr>
      <td>442.45</td>
      <td>3.04171</td>
      <td>120.44</td>
    </tr>
  </tbody>
</table>
<table>
  <tr>
    <td>674.32</td>
    <td>2 931.76</td>
    <td>53.06</td>
    <td>1 697.25</td>
    <td>31.85</td>
    <td>40 637.73</td>
    <td>581.07</td>
    <td>299 805.88</td>
    <td>3 247.55</td>
    <td>0.48</td>
    <td>0.08</td>
    <td>148.80</td>
    <td>5.76</td>
    <td>1.44</td>
    <td>0.31</td>
    <td>236.65</td>
    <td>6.24</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>7.02</td>
    <td>0.61</td>
    <td>250.58</td>
    <td>4.81</td>
    <td>12.47</td>
    <td>0.32</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.98</td>
    <td>0.08</td>
  </tr>
  <tr>
    <td>676.44</td>
    <td>2 878.09</td>
    <td>65.96</td>
    <td>1 683.82</td>
    <td>23.93</td>
    <td>40 971.47</td>
    <td>669.36</td>
    <td>296 499.25</td>
    <td>3 609.96</td>
    <td>0.63</td>
    <td>0.14</td>
    <td>150.15</td>
    <td>4.84</td>
    <td>1.76</td>
    <td>0.32</td>
    <td>231.39</td>
    <td>5.52</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>6.49</td>
    <td>0.55</td>
    <td>251.34</td>
    <td>4.91</td>
    <td>11.96</td>
    <td>0.38</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.82</td>
    <td>0.11</td>
  </tr>
  <tr>
    <td>678.57</td>
    <td>2 846.99</td>
    <td>73.21</td>
    <td>1 645.88</td>
    <td>22.95</td>
    <td>41 131.68</td>
    <td>575.78</td>
    <td>295 318.65</td>
    <td>2 699.89</td>
    <td>0.51</td>
    <td>0.12</td>
    <td>143.71</td>
    <td>2.88</td>
    <td>1.68</td>
    <td>0.37</td>
    <td>218.01</td>
    <td>4.88</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>6.19</td>
    <td>0.45</td>
    <td>251.39</td>
    <td>3.07</td>
    <td>11.42</td>
    <td>0.22</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.56</td>
    <td>0.10</td>
  </tr>
  <tr>
    <td>680.70</td>
    <td>2 851.77</td>
    <td>56.07</td>
    <td>1 617.65</td>
    <td>24.60</td>
    <td>41 262.11</td>
    <td>459.13</td>
    <td>297 607.44</td>
    <td>3 057.71</td>
    <td>0.30</td>
    <td>0.08</td>
    <td>136.61</td>
    <td>2.06</td>
    <td>1.46</td>
    <td>0.35</td>
    <td>207.37</td>
    <td>2.58</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>7.82</td>
    <td>0.58</td>
    <td>253.01</td>
    <td>4.32</td>
    <td>11.36</td>
    <td>0.14</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.39</td>
    <td>0.06</td>
  </tr>
  <tr>
    <td>682.82</td>
    <td>2 891.25</td>
    <td>50.63</td>
    <td>1 650.86</td>
    <td>32.68</td>
    <td>42 230.16</td>
    <td>455.13</td>
    <td>303 432.57</td>
    <td>3 193.86</td>
    <td>0.38</td>
    <td>0.11</td>
    <td>135.51</td>
    <td>2.64</td>
    <td>1.34</td>
    <td>0.20</td>
    <td>211.71</td>
    <td>5.02</td>
    <td>0.01</td>
    <td>0.01</td>
    <td>9.77</td>
    <td>1.03</td>
    <td>259.48</td>
    <td>4.73</td>
    <td>11.94</td>
    <td>0.30</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.29</td>
    <td>0.05</td>
  </tr>
  <tr>
    <td>684.95</td>
    <td>2 903.99</td>
    <td>70.72</td>
    <td>1 715.01</td>
    <td>39.76</td>
    <td>43 161.38</td>
    <td>529.37</td>
    <td>308 497.88</td>
    <td>3 689.81</td>
    <td>0.52</td>
    <td>0.15</td>
    <td>136.39</td>
    <td>2.52</td>
    <td>0.95</td>
    <td>0.14</td>
    <td>226.65</td>
    <td>6.30</td>
    <td>0.11</td>
    <td>0.08</td>
    <td>9.94</td>
    <td>1.62</td>
    <td>265.71</td>
    <td>4.32</td>
    <td>12.55</td>
    <td>0.31</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.20</td>
    <td>0.05</td>
  </tr>
  <tr>
    <td>687.08</td>
    <td>2 912.98</td>
    <td>70.38</td>
    <td>1 772.32</td>
    <td>35.34</td>
    <td>43 513.25</td>
    <td>675.93</td>
    <td>312 222.61</td>
    <td>4 930.83</td>
    <td>0.51</td>
    <td>0.16</td>
    <td>133.36</td>
    <td>2.81</td>
    <td>0.49</td>
    <td>0.11</td>
    <td>237.45</td>
    <td>5.82</td>
    <td>0.36</td>
    <td>0.22</td>
    <td>7.92</td>
    <td>1.12</td>
    <td>268.45</td>
    <td>4.41</td>
    <td>12.81</td>
    <td>0.35</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.10</td>
    <td>0.07</td>
  </tr>
  <tr>
    <td>689.21</td>
    <td>2 941.25</td>
    <td>67.83</td>
    <td>1 788.14</td>
    <td>28.67</td>
    <td>43 194.99</td>
    <td>681.89</td>
    <td>312 859.07</td>
    <td>4 369.03</td>
    <td>0.35</td>
    <td>0.09</td>
    <td>129.84</td>
    <td>2.16</td>
    <td>0.26</td>
    <td>0.11</td>
    <td>239.02</td>
    <td>5.27</td>
    <td>0.40</td>
    <td>0.21</td>
    <td>7.59</td>
    <td>1.14</td>
    <td>267.79</td>
    <td>4.37</td>
    <td>12.77</td>
    <td>0.24</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.05</td>
    <td>0.07</td>
  </tr>
  <tr>
    <td>691.33</td>
    <td>2 930.23</td>
    <td>72.15</td>
    <td>1 795.24</td>
    <td>32.40</td>
    <td>42 720.13</td>
    <td>745.74</td>
    <td>311 480.52</td>
    <td>4 022.55</td>
    <td>0.23</td>
    <td>0.04</td>
    <td>129.23</td>
    <td>1.88</td>
    <td>0.27</td>
    <td>0.18</td>
    <td>244.01</td>
    <td>3.84</td>
    <td>0.15</td>
    <td>0.07</td>
    <td>9.42</td>
    <td>1.35</td>
    <td>266.79</td>
    <td>5.32</td>
    <td>12.63</td>
    <td>0.22</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.07</td>
    <td>0.06</td>
  </tr>
  <tr>
    <td>693.46</td>
    <td>2 887.93</td>
    <td>69.49</td>
    <td>1 842.12</td>
    <td>39.97</td>
    <td>42 110.32</td>
    <td>807.92</td>
    <td>312 344.55</td>
    <td>4 303.03</td>
    <td>0.17</td>
    <td>0.02</td>
    <td>138.13</td>
    <td>2.15</td>
    <td>0.29</td>
    <td>0.15</td>
    <td>260.02</td>
    <td>4.01</td>
    <td>0.02</td>
    <td>0.01</td>
    <td>8.74</td>
    <td>0.52</td>
    <td>267.10</td>
    <td>5.73</td>
    <td>12.77</td>
    <td>0.28</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.18</td>
    <td>0.06</td>
  </tr>
  <tr>
    <td>695.59</td>
    <td>2 757.78</td>
    <td>72.73</td>
    <td>1 807.74</td>
    <td>40.63</td>
    <td>42 702.27</td>
    <td>709.13</td>
    <td>304 916.18</td>
    <td>4 479.92</td>
    <td>0.17</td>
    <td>0.03</td>
    <td>143.32</td>
    <td>1.98</td>
    <td>0.33</td>
    <td>0.11</td>
    <td>262.06</td>
    <td>4.42</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>7.34</td>
    <td>0.83</td>
    <td>260.47</td>
    <td>3.78</td>
    <td>12.86</td>
    <td>0.32</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.32</td>
    <td>0.07</td>
  </tr>
  <tr>
    <td>697.72</td>
    <td>2 570.87</td>
    <td>72.23</td>
    <td>1 661.85</td>
    <td>31.42</td>
    <td>40 939.54</td>
    <td>759.54</td>
    <td>287 990.10</td>
    <td>5 591.92</td>
    <td>0.16</td>
    <td>0.04</td>
    <td>137.26</td>
    <td>3.46</td>
    <td>0.37</td>
    <td>0.08</td>
    <td>241.70</td>
    <td>8.05</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>6.72</td>
    <td>1.06</td>
    <td>247.21</td>
    <td>2.67</td>
    <td>12.03</td>
    <td>0.32</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.36</td>
    <td>0.08</td>
  </tr>
  <tr>
    <td>699.84</td>
    <td>2 366.92</td>
    <td>114.47</td>
    <td>1 507.90</td>
    <td>51.02</td>
    <td>38 268.45</td>
    <td>1346.73</td>
    <td>267 241.71</td>
    <td>10 147.69</td>
    <td>0.10</td>
    <td>0.02</td>
    <td>130.71</td>
    <td>3.01</td>
    <td>0.27</td>
    <td>0.09</td>
    <td>222.02</td>
    <td>12.38</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>6.03</td>
    <td>0.54</td>
    <td>229.92</td>
    <td>6.50</td>
    <td>10.96</td>
    <td>0.56</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.29</td>
    <td>0.06</td>
  </tr>
  <tr>
    <td>701.97</td>
    <td>2 169.12</td>
    <td>135.98</td>
    <td>1 386.74</td>
    <td>66.96</td>
    <td>35 229.23</td>
    <td>1 719.81</td>
    <td>246 390.13</td>
    <td>12 836.94</td>
    <td>0.10</td>
    <td>0.02</td>
    <td>133.66</td>
    <td>2.17</td>
    <td>0.10</td>
    <td>0.04</td>
    <td>217.12</td>
    <td>9.46</td>
    <td>0.01</td>
    <td>0.01</td>
    <td>6.73</td>
    <td>0.59</td>
    <td>209.65</td>
    <td>10.02</td>
    <td>10.04</td>
    <td>0.76</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>1.15</td>
    <td>0.02</td>
  </tr>
  <tr>
    <td>704.10</td>
    <td>2 014.45</td>
    <td>134.60</td>
    <td>1 317.43</td>
    <td>68.96</td>
    <td>32 760.99</td>
    <td>1 861.10</td>
    <td>230 925.53</td>
    <td>13 953.03</td>
    <td>0.17</td>
    <td>0.06</td>
    <td>142.24</td>
    <td>3.30</td>
    <td>0.04</td>
    <td>0.01</td>
    <td>213.43</td>
    <td>7.08</td>
    <td>0.08</td>
    <td>0.07</td>
    <td>8.67</td>
    <td>0.91</td>
    <td>192.77</td>
    <td>11.75</td>
    <td>9.30</td>
    <td>0.63</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>0.99</td>
    <td>0.03</td>
  </tr>
  <tr>
    <td>706.22</td>
    <td>1 887.37</td>
    <td>141.33</td>
    <td>1 257.65</td>
    <td>84.50</td>
    <td>30 549.64</td>
    <td>2 069.61</td>
    <td>217 051.91</td>
    <td>15 512.11</td>
    <td>0.14</td>
    <td>0.05</td>
    <td>143.07</td>
    <td>3.91</td>
    <td>0.16</td>
    <td>0.04</td>
    <td>191.95</td>
    <td>10.44</td>
    <td>0.22</td>
    <td>0.16</td>
    <td>9.79</td>
    <td>0.84</td>
    <td>180.88</td>
    <td>13.64</td>
    <td>8.55</td>
    <td>0.52</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>0.89</td>
    <td>0.07</td>
  </tr>
  <tr>
    <td>708.35</td>
    <td>1 887.32</td>
    <td>123.20</td>
    <td>1 227.78</td>
    <td>95.45</td>
    <td>29 563.73</td>
    <td>2 088.22</td>
    <td>209 275.48</td>
    <td>15 335.79</td>
    <td>0.06</td>
    <td>0.02</td>
    <td>136.27</td>
    <td>3.99</td>
    <td>0.34</td>
    <td>0.11</td>
    <td>174.23</td>
    <td>12.56</td>
    <td>0.21</td>
    <td>0.13</td>
    <td>9.58</td>
    <td>0.68</td>
    <td>175.91</td>
    <td>13.41</td>
    <td>8.26</td>
    <td>0.66</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>0.88</td>
    <td>0.10</td>
  </tr>
  <tr>
    <td>710.48</td>
    <td>2 020.40</td>
    <td>154.76</td>
    <td>1 271.44</td>
    <td>128.02</td>
    <td>30 728.39</td>
    <td>2 697.76</td>
    <td>216 676.46</td>
    <td>20 017.89</td>
    <td>0.09</td>
    <td>0.02</td>
    <td>132.20</td>
    <td>5.86</td>
    <td>0.28</td>
    <td>0.11</td>
    <td>184.73</td>
    <td>16.47</td>
    <td>0.07</td>
    <td>0.04</td>
    <td>8.22</td>
    <td>0.32</td>
    <td>182.95</td>
    <td>16.08</td>
    <td>8.69</td>
    <td>0.87</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>0.90</td>
    <td>0.13</td>
  </tr>
  <tr>
    <td>712.61</td>
    <td>2 179.18</td>
    <td>176.19</td>
    <td>1 368.17</td>
    <td>140.37</td>
    <td>33 518.35</td>
    <td>2 968.28</td>
    <td>236 652.91</td>
    <td>21 898.65</td>
    <td>0.30</td>
    <td>0.06</td>
    <td>134.91</td>
    <td>5.02</td>
    <td>0.20</td>
    <td>0.06</td>
    <td>214.23</td>
    <td>18.70</td>
    <td>0.11</td>
    <td>0.07</td>
    <td>7.00</td>
    <td>0.53</td>
    <td>201.84</td>
    <td>17.43</td>
    <td>9.32</td>
    <td>0.87</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>0.86</td>
    <td>0.12</td>
  </tr>
  <tr>
    <td>714.73</td>
    <td>2 381.68</td>
    <td>143.93</td>
    <td>1 549.51</td>
    <td>115.98</td>
    <td>37 880.65</td>
    <td>2 437.63</td>
    <td>266 985.59</td>
    <td>17 606.85</td>
    <td>0.47</td>
    <td>0.08</td>
    <td>143.32</td>
    <td>3.40</td>
    <td>0.37</td>
    <td>0.16</td>
    <td>252.00</td>
    <td>17.19</td>
    <td>0.59</td>
    <td>0.23</td>
    <td>7.69</td>
    <td>0.98</td>
    <td>230.87</td>
    <td>13.81</td>
    <td>10.25</td>
    <td>0.67</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>0.82</td>
    <td>0.07</td>
  </tr>
  <tr>
    <td>716.86</td>
    <td>2 601.60</td>
    <td>113.31</td>
    <td>1 725.41</td>
    <td>77.51</td>
    <td>41 675.24</td>
    <td>1 649.05</td>
    <td>291 186.03</td>
    <td>12 174.70</td>
    <td>0.46</td>
    <td>0.06</td>
    <td>147.20</td>
    <td>3.12</td>
    <td>0.42</td>
    <td>0.18</td>
    <td>278.21</td>
    <td>14.69</td>
    <td>1.41</td>
    <td>0.36</td>
    <td>9.08</td>
    <td>1.72</td>
    <td>253.54</td>
    <td>9.09</td>
    <td>10.92</td>
    <td>0.46</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>0.82</td>
    <td>0.05</td>
  </tr>
  <tr>
    <td>718.99</td>
    <td>2 835.94</td>
    <td>105.79</td>
    <td>1 801.21</td>
    <td>53.08</td>
    <td>434.31.47</td>
    <td>1201.97</td>
    <td>305 807.11</td>
    <td>908.712</td>
    <td>0.47</td>
    <td>0.10</td>
    <td>143.68</td>
    <td>3.31</td>
    <td>0.26</td>
    <td>0.06</td>
    <td>284.62</td>
    <td>13.38</td>
    <td>1.73</td>
    <td>0.48</td>
    <td>8.80</td>
    <td>1.84</td>
    <td>259.79</td>
    <td>6.47</td>
    <td>10.88</td>
    <td>0.53</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>0.82</td>
    <td>0.04</td>
  </tr>
  <tr>
    <td>721.11</td>
    <td>3015.38</td>
    <td>84.08</td>
    <td>1827.79</td>
    <td>47.38</td>
    <td>44122.76</td>
    <td>1152.58</td>
    <td>310591.39</td>
    <td>8065.33</td>
    <td>0.40</td>
    <td>0.10</td>
    <td>140.86</td>
    <td>3.94</td>
    <td>0.31</td>
    <td>0.08</td>
    <td>273.66</td>
    <td>10.89</td>
    <td>1.29</td>
    <td>0.30</td>
    <td>8.89</td>
    <td>0.98</td>
    <td>256.14</td>
    <td>6.66</td>
    <td>10.48</td>
    <td>0.66</td>
    <td>0.00</td>
    <td>0.00</td>
    <td>0.76</td>
    <td>0.04</td>
  </tr>
</table>
<table><tr><td>383.40</td><td>2 863.03</td><td>3.77</td><td>1 141.98</td><td>13.79</td><td>43 935.24</td><td>264.10</td><td>300 284.73</td><td>1 291.03</td><td>0.62</td><td>0.15</td><td>229.15</td><td>1.40</td><td>1.04</td><td>0.15</td><td>239.56</td><td>10.30</td><td>0.39</td><td>0.22</td><td>4.47</td><td>0.67</td><td>203.12</td><td>1.33</td><td>9.06</td><td>0.46</td><td>0.00</td><td>0.00</td><td>0.24</td><td>0.02</td></tr><tr><td>385.49</td><td>2 935.73</td><td>19.57</td><td>1 073.50</td><td>6.46</td><td>42 250.43</td><td>251.25</td><td>294 728.67</td><td>2 245.33</td><td>0.65</td><td>0.20</td><td>220.23</td><td>1.05</td><td>0.39</td><td>0.04</td><td>212.36</td><td>9.81</td><td>0.44</td><td>0.22</td><td>6.04</td><td>0.94</td><td>194.65</td><td>0.46</td><td>8.00</td><td>0.36</td><td>0.00</td><td>0.00</td><td>0.19</td><td>0.02</td></tr><tr><td>387.59</td><td>2 962.13</td><td>27.92</td><td>1 035.35</td><td>7.09</td><td>41 505.41</td><td>169.55</td><td>293 534.06</td><td>3 279.68</td><td>0.58</td><td>0.22</td><td>214.49</td><td>1.31</td><td>0.15</td><td>0.08</td><td>200.30</td><td>6.35</td><td>0.58</td><td>0.12</td><td>7.45</td><td>1.24</td><td>192.95</td><td>1.48</td><td>7.55</td><td>0.16</td><td>0.00</td><td>0.00</td><td>0.17</td><td>0.02</td></tr><tr><td>389.68</td><td>2 915.61</td><td>29.91</td><td>1 040.06</td><td>6.71</td><td>41 727.04</td><td>175.24</td><td>294 424.43</td><td>3 565.34</td><td>0.52</td><td>0.19</td><td>218.48</td><td>1.46</td><td>0.37</td><td>0.22</td><td>200.55</td><td>2.86</td><td>1.07</td><td>0.34</td><td>7.07</td><td>0.98</td><td>198.23</td><td>1.85</td><td>7.92</td><td>0.14</td><td>0.00</td><td>0.00</td><td>0.20</td><td>0.02</td></tr><tr><td>391.78</td><td>2 856.57</td><td>32.90</td><td>1 068.80</td><td>21.22</td><td>42 001.02</td><td>111.48</td><td>292 175.47</td><td>2 429.20</td><td>0.44</td><td>0.13</td><td>228.98</td><td>1.04</td><td>1.08</td><td>0.32</td><td>202.52</td><td>3.92</td><td>1.43</td><td>0.39</td><td>5.68</td><td>0.61</td><td>201.45</td><td>1.96</td><td>8.33</td><td>0.05</td><td>0.00</td><td>0.00</td><td>0.20</td><td>0.00</td></tr><tr><td>393.87</td><td>2 834.26</td><td>29.95</td><td>1 115.36</td><td>17.70</td><td>42 433.30</td><td>132.68</td><td>290 349.91</td><td>978.09</td><td>0.49</td><td>0.08</td><td>236.92</td><td>5.18</td><td>2.00</td><td>0.15</td><td>196.70</td><td>1.46</td><td>1.49</td><td>0.46</td><td>5.52</td><td>0.42</td><td>206.52</td><td>0.98</td><td>8.58</td><td>0.24</td><td>0.00</td><td>0.00</td><td>0.18</td><td>0.02</td></tr><tr><td>395.97</td><td>2 849.68</td><td>8.10</td><td>1 130.76</td><td>19.83</td><td>42 915.38</td><td>268.10</td><td>292 503.09</td><td>1 420.74</td><td>0.57</td><td>0.09</td><td>237.49</td><td>6.61</td><td>2.24</td><td>0.18</td><td>192.83</td><td>5.34</td><td>1.32</td><td>0.47</td><td>7.25</td><td>0.84</td><td>208.90</td><td>2.55</td><td>8.68</td><td>0.25</td><td>0.00</td><td>0.00</td><td>0.16</td><td>0.03</td></tr></table>