<table>
  <tr>
    <td>604</td>
    <td>ENSDARP00000026554</td>
    <td>psmc3</td>
    <td>psmc3-201</td>
    <td>Proteasome (prosome, macropain) 26S subunit, ATPase, 3</td>
    <td>Protein degradation and synthesis inhibition</td>
    <td>GQ INCREASED</td>
    <td>0.40</td>
  </tr>
  <tr>
    <td>605</td>
    <td>ENSDARP00000081816</td>
    <td>ddx6</td>
    <td>ddx6-201</td>
    <td>DEAD (Asp-Glu-Ala-Asp) box helicase 6</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.40</td>
  </tr>
  <tr>
    <td>606</td>
    <td>ENSDARP00000120609</td>
    <td>rps18</td>
    <td>rps-202</td>
    <td>Small subunit ribosomal protein S18e</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.39</td>
  </tr>
  <tr>
    <td>607</td>
    <td>ENSDARP0000016831</td>
    <td>cct6a</td>
    <td>cct6a-201</td>
    <td>Chaperonin containing TCP1, subunit 6A</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.39</td>
  </tr>
  <tr>
    <td>608</td>
    <td>ENSDARP00000118006</td>
    <td>cct6a</td>
    <td>cct6a-001</td>
    <td>Chaperonin containing TCP1, subunit 6A</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.39</td>
  </tr>
  <tr>
    <td>609</td>
    <td>ENSDARP00000063876</td>
    <td>prdx6</td>
    <td>prdx6-001</td>
    <td>Peroxiredoxin 6</td>
    <td>REDOX/Detox related</td>
    <td>GQ INCREASED</td>
    <td>0.39</td>
  </tr>
  <tr>
    <td>610</td>
    <td>ENSDARP00000013402</td>
    <td>cat</td>
    <td>cat-201</td>
    <td>Catalase</td>
    <td>REDOX/Detox related</td>
    <td>GQ INCREASED</td>
    <td>0.38</td>
  </tr>
  <tr>
    <td>611</td>
    <td>ENSDARP00000107673</td>
    <td>cat</td>
    <td>cat-202</td>
    <td>Catalase</td>
    <td>REDOX/Detox related</td>
    <td>GQ INCREASED</td>
    <td>0.38</td>
  </tr>
  <tr>
    <td>612</td>
    <td>ENSDARP00000098561</td>
    <td>cnp</td>
    <td>cnp-202</td>
    <td>2'-3'-cyclic nucleotide 3' phosphodiesterase</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.38</td>
  </tr>
  <tr>
    <td>613</td>
    <td>ENSDARP00000117370</td>
    <td>cnp</td>
    <td>cnp-001</td>
    <td>2'-3'-cyclic nucleotide 3' phosphodiesterase</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.38</td>
  </tr>
  <tr>
    <td>614</td>
    <td>ENSDARP00000093249</td>
    <td>dars</td>
    <td>dars-201</td>
    <td>Aspartyl-tRNA synthetase</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.38</td>
  </tr>
  <tr>
    <td>615</td>
    <td>ENSDARP00000090277</td>
    <td>shmt2</td>
    <td>shmt2-201</td>
    <td>Serine hydroxymethyltransferase 2 (mitochondrial)</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.37</td>
  </tr>
  <tr>
    <td>616</td>
    <td>ENSDARP00000051290</td>
    <td>hexa</td>
    <td>hexa-001</td>
    <td>Hexosaminidase A (alpha polypeptide)</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.37</td>
  </tr>
  <tr>
    <td>617</td>
    <td>ENSDARP00000042258</td>
    <td>cybl</td>
    <td>cybl-001</td>
    <td>Citrate lyase subunit beta / citryl-CoA lyase</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.37</td>
  </tr>
  <tr>
    <td>618</td>
    <td>ENSDARP00000025466</td>
    <td>cct4</td>
    <td>cct4-201</td>
    <td>Chaperonin containing Tcp1, subunit 4</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.37</td>
  </tr>
  <tr>
    <td>619</td>
    <td>ENSDARP00000102802</td>
    <td>shmt2</td>
    <td>shmt2-202</td>
    <td>Serine hydroxymethyltransferase 2 (mitochondrial)</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.37</td>
  </tr>
  <tr>
    <td>620</td>
    <td>ENSDARP00000074247</td>
    <td>vdac3</td>
    <td>vdac3-201</td>
    <td>Voltage-dependent anion channel 3</td>
    <td>Other</td>
    <td>GQ INCREASED</td>
    <td>0.37</td>
  </tr>
  <tr>
    <td>621</td>
    <td>ENSDARP00000121437</td>
    <td>vdac3</td>
    <td>vdac3-001</td>
    <td>Voltage-dependent anion channel 3</td>
    <td>Other</td>
    <td>GQ INCREASED</td>
    <td>0.37</td>
  </tr>
  <tr>
    <td>622</td>
    <td>ENSDARP00000101564</td>
    <td>CJ914772 1</td>
    <td>CJ914772 1-201</td>
    <td>Glyoxalase</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.37</td>
  </tr>
  <tr>
    <td>623</td>
    <td>ENSDARP00000102398</td>
    <td>ef1s10</td>
    <td>ef1s10-001</td>
    <td>Eukaryotic translation initiation factor</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.37</td>
  </tr>
  <tr>
    <td>624</td>
    <td>ENSDARP00000052502</td>
    <td>nudcd1</td>
    <td>nudcd1-001</td>
    <td>NudC domain containing 1</td>
    <td>Other</td>
    <td>GQ INCREASED</td>
    <td>0.36</td>
  </tr>
  <tr>
    <td>625</td>
    <td>ENSDARP00000111483</td>
    <td>kpa2</td>
    <td>kpa2-202</td>
    <td>Karyopherin alpha 2</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.36</td>
  </tr>
  <tr>
    <td>626</td>
    <td>ENSDARP00000055489</td>
    <td>kpa2</td>
    <td>kpa2-001</td>
    <td>Karyopherin alpha 2</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.36</td>
  </tr>
  <tr>
    <td>627</td>
    <td>ENSDARP00000117923</td>
    <td>eno3</td>
    <td>eno3-002</td>
    <td>Enolase 3</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.36</td>
  </tr>
  <tr>
    <td>628</td>
    <td>ENSDARP0000014955</td>
    <td>man2b1</td>
    <td>man2b1-001</td>
    <td>Mannosidase, alpha, class 2B, member 1</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>629</td>
    <td>ENSDARP0000006424</td>
    <td>aga1</td>
    <td>aga1-201</td>
    <td>Amylo-1, 6-glucosidase, 4-alpha-glucanotransferase a</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>630</td>
    <td>ENSDARP00000129094</td>
    <td>aga1</td>
    <td>aga1-001</td>
    <td>Amylo-1, 6-glucosidase, 4-alpha-glucanotransferase a</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>631</td>
    <td>ENSDARP0000006682</td>
    <td>me3</td>
    <td>me3-001</td>
    <td>Malic enzyme</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>632</td>
    <td>ENSDARP00000075198</td>
    <td>ubc3</td>
    <td>ubc3-001</td>
    <td>Ubiquitin-like modifier activating enzyme 3</td>
    <td>Protein degradation and synthesis inhibition</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>633</td>
    <td>ENSDARP00000123554</td>
    <td>pccb</td>
    <td>pccb-201</td>
    <td>Pyruvate carboxylase b</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>634</td>
    <td>ENSDARP00000041577</td>
    <td>stx12</td>
    <td>stx12-201</td>
    <td>Syntaxin 12/13</td>
    <td>Other</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>635</td>
    <td>ENSDARP00000107727</td>
    <td>stx12</td>
    <td>stx12-001</td>
    <td>Syntaxin 12/13</td>
    <td>Other</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>636</td>
    <td>ENSDARP00000072874</td>
    <td>rps8a</td>
    <td>rps8a-001</td>
    <td>Ribosomal protein S8a</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>637</td>
    <td>ENSDARP00000123532</td>
    <td>vdac3</td>
    <td>vdac3-002</td>
    <td>Voltage-dependent anion channel 3</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>638</td>
    <td>ENSDARP00000003850</td>
    <td>akr7a3</td>
    <td>akr7a3-201</td>
    <td>Aldo-keto reductase family 7, member A3 -aflatoxin B1 aldehyde reductase</td>
    <td>REDOX/Detox related</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>639</td>
    <td>ENSDARP00000005719</td>
    <td>rps18</td>
    <td>rps18-001</td>
    <td>Small subunit ribosomal protein S18e</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>640</td>
    <td>ENSDARP00000008399</td>
    <td>drg2</td>
    <td>drg2-001</td>
    <td>Developmentally regulated GTP binding protein 2</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>641</td>
    <td>ENSDARP00000105639</td>
    <td>drg2</td>
    <td>drg2-002</td>
    <td>Developmentally regulated GTP binding protein 2</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.35</td>
  </tr>
  <tr>
    <td>642</td>
    <td>ENSDARP00000112087</td>
    <td>zgc-158614</td>
    <td>zgc-158614-202</td>
    <td>Aifm4-apoptosis-inducing factor, mitochondrion-associated 4</td>
    <td>Apoptosis related</td>
    <td>GQ INCREASED</td>
    <td>0.34</td>
  </tr>
  <tr>
    <td>643</td>
    <td>ENSDARP00000129114</td>
    <td>zgc-158614</td>
    <td>zgc-158614-001</td>
    <td>Aifm4-apoptosis-inducing factor, mitochondrion-associated 4</td>
    <td>Apoptosis related</td>
    <td>GQ INCREASED</td>
    <td>0.34</td>
  </tr>
  <tr>
    <td>644</td>
    <td>ENSDARP00000110981</td>
    <td>dars</td>
    <td>dars-202</td>
    <td>Aspartyl-tRNA synthetase</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.33</td>
  </tr>
  <tr>
    <td>645</td>
    <td>ENSDARP00000116150</td>
    <td>uap1</td>
    <td>uap1-002</td>
    <td>UDP-N-acteylglucosamine pyrophosphorylase 1</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.33</td>
  </tr>
  <tr>
    <td>646</td>
    <td>ENSDARP00000005651</td>
    <td>rpl8</td>
    <td>rpl8-201</td>
    <td>Ribosomal protein L8</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.33</td>
  </tr>
  <tr>
    <td>647</td>
    <td>ENSDARP000000115147</td>
    <td>rpl8</td>
    <td>rpl8-001</td>
    <td>Ribosomal protein L8</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.33</td>
  </tr>
  <tr>
    <td>648</td>
    <td>ENSDARP00000006244</td>
    <td>dnpep</td>
    <td>dnpep-001</td>
    <td>Aspartyl aminopeptidase</td>
    <td>Protein degradation and synthesis inhibition</td>
    <td>GQ INCREASED</td>
    <td>0.33</td>
  </tr>
  <tr>
    <td>649</td>
    <td>ENSDARP00000110484</td>
    <td>dnpep</td>
    <td>dnpep-201</td>
    <td>Aspartyl aminopeptidase</td>
    <td>Protein degradation and synthesis inhibition</td>
    <td>GQ INCREASED</td>
    <td>0.33</td>
  </tr>
  <tr>
    <td>650</td>
    <td>ENSDARP00000027655</td>
    <td>mpep</td>
    <td>mpep-001</td>
    <td>Cytochrome-c peroxidase</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.33</td>
  </tr>
  <tr>
    <td>651</td>
    <td>ENSDARP00000098660</td>
    <td>snmp200</td>
    <td>snmp200-001</td>
    <td>Small nuclear ribonucleoprotein 200kDa</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.32</td>
  </tr>
  <tr>
    <td>652</td>
    <td>ENSDARP00000070479</td>
    <td>cpdb</td>
    <td>cpdb-001</td>
    <td>Carboxypeptidase D, b</td>
    <td>Protein degradation and synthesis inhibition</td>
    <td>GQ INCREASED</td>
    <td>0.30</td>
  </tr>
  <tr>
    <td>653</td>
    <td>ENSDARP00000040031</td>
    <td>rtn4ip1</td>
    <td>rtn4ip1-001</td>
    <td>Reticulon 4 interacting protein 1</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>654</td>
    <td>ENSDARP00000124612</td>
    <td>glyc1</td>
    <td>glyc1-004</td>
    <td>Glycerate kinase</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>655</td>
    <td>ENSDARP00000121663</td>
    <td>cybl</td>
    <td>cybl-002</td>
    <td>Citrate lyase subunit beta / citryl-CoA lyase</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>656</td>
    <td>ENSDARP00000114273</td>
    <td>tceb2</td>
    <td>tceb2-001</td>
    <td>Transcription elongation factor B, polypeptide 2</td>
    <td>Protein degradation and synthesis inhibition</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>657</td>
    <td>ENSDARP00000128442</td>
    <td>zgc-158614</td>
    <td>zgc-158614-003</td>
    <td>Aifm4-apoptosis-inducing factor, mitochondrion-associated 4</td>
    <td>Apoptosis related</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>658</td>
    <td>ENSDARP000000055359</td>
    <td>tceb2</td>
    <td>tceb2-002</td>
    <td>Transcription elongation factor B, polypeptide 2</td>
    <td>Protein degradation and synthesis inhibition</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>659</td>
    <td>ENSDARP000000084961</td>
    <td>rhoae</td>
    <td>rhoae-001</td>
    <td>Ras homolog gene family, member A</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>660</td>
    <td>ENSDARP00000123757</td>
    <td>glyc1</td>
    <td>glyc1-003</td>
    <td>Glycerate kinase</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>661</td>
    <td>ENSDARP00000118814</td>
    <td>rpl23a</td>
    <td>rpl23a-004</td>
    <td>Large subunit ribosomal protein L32a</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>662</td>
    <td>ENSDARP0000010485</td>
    <td>zgc-158614</td>
    <td>zgc-158614-201</td>
    <td>Aifm4-apoptosis-inducing factor, mitochondrion-associated 4</td>
    <td>Apoptosis related</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>663</td>
    <td>ENSDARP00000002234</td>
    <td>oct1a</td>
    <td>oct1a-001</td>
    <td>3-oxoacid CoA transferase 1a</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>664</td>
    <td>ENSDARP00000089234</td>
    <td>APOD (3 of 3)</td>
    <td>APOD (3 of 3)-201</td>
    <td>Apolipoprotein D</td>
    <td>Lipid metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>665</td>
    <td>ENSDARP00000113343</td>
    <td>APOD (3 of 3)</td>
    <td>APOD (3 of 3)-001</td>
    <td>Apolipoprotein D</td>
    <td>Lipid metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>666</td>
    <td>ENSDARP00000117077</td>
    <td>APOD (3 of 3)</td>
    <td>APOD (3 of 3)-004</td>
    <td>Apolipoprotein D</td>
    <td>Lipid metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>667</td>
    <td>ENSDARP00000123122</td>
    <td>APOD (3 of 3)</td>
    <td>APOD (3 of 3)-003</td>
    <td>Apolipoprotein D</td>
    <td>Lipid metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>668</td>
    <td>ENSDARP00000123418</td>
    <td>APOD (3 of 3)</td>
    <td>APOD (3 of 3)-002</td>
    <td>Apolipoprotein D</td>
    <td>Lipid metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>669</td>
    <td>ENSDARP00000035324</td>
    <td>selenbp1</td>
    <td>selenbp1-201</td>
    <td>Selenium binding protein 1</td>
    <td>Protein Synthesis</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>670</td>
    <td>ENSDARP00000062697</td>
    <td>ephx1</td>
    <td>ephx1-001</td>
    <td>Ephoxide hydrolase 1, microsomal (xenobiotic)</td>
    <td>REDOX/Detox related</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
  <tr>
    <td>671</td>
    <td>ENSDARP00000121216</td>
    <td>rhoad</td>
    <td>rhoad-002</td>
    <td>Ras homolog gene family, member A</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.29</td>
  </tr>
</table>
<table><thead><tr><th></th><th></th><th></th><th></th><th></th><th></th><th></th></tr></thead><tbody><tr><td>672</td><td>ENSDARP00000006624</td><td>rpl23a</td><td>rpl23a-001</td><td>Large subunit ribosomal protein L32e</td><td>Protein Synthesis</td><td>GQ INCREASED 0.29</td></tr><tr><td>673</td><td>ENSDARP00000022829</td><td>dph5</td><td>dph5-201</td><td>Diphthine synthase</td><td>Protein Synthesis</td><td>GQ INCREASED 0.29</td></tr><tr><td>674</td><td>ENSDARP00000108734</td><td>dph5</td><td>dph5-202</td><td>Diphthine synthase</td><td>Protein Synthesis</td><td>GQ INCREASED 0.29</td></tr><tr><td>675</td><td>ENSDARP00000111794</td><td>dph5</td><td>dph5-203</td><td>Diphthine synthase</td><td>Protein Synthesis</td><td>GQ INCREASED 0.29</td></tr><tr><td>676</td><td>ENSDARP00000082459</td><td>prmt5</td><td>prmt5-201</td><td>Protein arginine methyltransferase 5</td><td>Protein Synthesis</td><td>GQ INCREASED 0.29</td></tr><tr><td>677</td><td>ENSDARP00000116916</td><td>rps18</td><td>rps18-002</td><td>Small subunit ribosomal protein S18e</td><td>Protein Synthesis</td><td>GQ INCREASED 0.29</td></tr><tr><td>678</td><td>ENSDARP00000122082</td><td>rps18</td><td>rps18-003</td><td>Small subunit ribosomal protein S18e</td><td>Protein Synthesis</td><td>GQ INCREASED 0.29</td></tr><tr><td>679</td><td>ENSDARP00000052267</td><td>pitpbn</td><td>pitpbn-201</td><td>Phosphatidylinositol transfer protein, beta, like</td><td>Lipid metabolism</td><td>GQ INCREASED 0.29</td></tr><tr><td>680</td><td>ENSDARP00000124921</td><td>sept7b</td><td></td><td>Cytoskeleton proteins</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED 0.29</td></tr><tr><td>681</td><td>ENSDARP00000068657</td><td>eiif2a</td><td>eiif2a-201</td><td>Eukaryotic translation initiation factor</td><td>Protein Synthesis</td><td>GQ INCREASED 0.29</td></tr><tr><td>682</td><td>ENSDARP00000125913</td><td>eiif2a</td><td>eiif2a-001</td><td>Eukaryotic translation initiation factor</td><td>Protein Synthesis</td><td>GQ INCREASED 0.29</td></tr><tr><td>683</td><td>ENSDARP00000115411</td><td>pdhb</td><td>pdhb-002</td><td>Pyruvate dehydrogenase (lipocamide) beta</td><td>Energy metabolism</td><td>GQ INCREASED 0.29</td></tr><tr><td>684</td><td>ENSDARP00000111558</td><td>pitpbn</td><td>pitpbn-202</td><td>Phosphatidylinositol transfer protein, beta, like</td><td>Lipid metabolism</td><td>GQ INCREASED 0.29</td></tr><tr><td>685</td><td>ENSDARP00000124765</td><td>glyck</td><td>glyck-002</td><td>Glycerate kinase</td><td>Energy metabolism</td><td>GQ INCREASED 0.29</td></tr><tr><td>686</td><td>ENSDARP00000109870</td><td>hdac10</td><td>hdac10-001</td><td>Histone deacetylase 10</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED 0.29</td></tr><tr><td>687</td><td>ENSDARP00000067534</td><td>cap2</td><td>cap2-201</td><td>CAP, adenylate cyclase-associated protein, 2 (yeast)</td><td>Other</td><td>GQ INCREASED 0.29</td></tr><tr><td>688</td><td>ENSDARP00000106164</td><td>citcb</td><td>citcb-201</td><td>Cistatin, heavy polypeptide b</td><td>Protein degradation and synthesis inhibition</td><td>GQ INCREASED 0.28</td></tr><tr><td>689</td><td>ENSDARP00000105470</td><td>citcb</td><td>citcb-202</td><td>Cistatin, heavy polypeptide b</td><td>Protein degradation and synthesis inhibition</td><td>GQ INCREASED 0.28</td></tr><tr><td>690</td><td>ENSDARP00000119038</td><td>citcb</td><td>citcb-001</td><td>Cistatin, heavy polypeptide b</td><td>Protein degradation and synthesis inhibition</td><td>GQ INCREASED 0.28</td></tr><tr><td>691</td><td>ENSDARP00000077445</td><td>acad9</td><td>acad9-001</td><td>Acyl-CoA dehydrogenase family, member 9</td><td>Energy metabolism</td><td>GQ INCREASED 0.28</td></tr><tr><td>692</td><td>ENSDARP00000103810</td><td>prep</td><td>prep-001</td><td>Prolyl endopeptidase</td><td>Protein degradation and synthesis inhibition</td><td>GQ INCREASED 0.26</td></tr><tr><td>693</td><td>ENSDARP00000077466</td><td>myh10</td><td>myh10-001</td><td>MP-dependent regulatory, type II, alpha A</td><td></td><td>GQ INCREASED 0.26</td></tr><tr><td>694</td><td>ENSDARP00000046358</td><td>myh10</td><td>myh10-201</td><td>Myosin, heavy chain 10, non-muscle</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED 0.26</td></tr><tr><td>695</td><td>ENSDARP00000125918</td><td>myh10</td><td>myh10-001</td><td>Myosin, heavy chain 10, non-muscle</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED 0.26</td></tr><tr><td>696</td><td>ENSDARP00000007817</td><td>farsb</td><td>farsb-001</td><td>Phenylalanyl-tRNA synthetase, beta subunit</td><td>Protein Synthesis</td><td>GQ INCREASED 0.26</td></tr><tr><td>697</td><td>ENSDARP00000125771</td><td>myh10</td><td>myh10-002</td><td>Myosin, heavy chain 10, non-muscle</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED 0.26</td></tr><tr><td>698</td><td>ENSDARP00000116604</td><td>selenbp1</td><td>selenbp1-001</td><td>Selenium binding protein 1</td><td>Protein Synthesis</td><td>GQ INCREASED 0.26</td></tr><tr><td>699</td><td>ENSDARP0000003986</td><td>pgm3</td><td>pgm3-001</td><td>Phosphoacetylglucosamine mutase</td><td>Energy metabolism</td><td>GQ INCREASED 0.26</td></tr><tr><td>700</td><td>ENSDARP00000023819</td><td>mcc2</td><td>mcc2-001</td><td>Methylcrotonoyl-CoA carboxylase 2 (beta)</td><td>Protein degradation and synthesis inhibition</td><td>GQ INCREASED 0.25</td></tr><tr><td>701</td><td>ENSDARP00000015404</td><td>ehd1a</td><td>ehd1a-201</td><td>EH domain-containing protein 1</td><td>Lipid metabolism</td><td>GQ INCREASED 0.25</td></tr><tr><td>702</td><td>ENSDARP00000057947</td><td>anxa11a</td><td>anxa11a-002</td><td>Annexin A11a</td><td>Immune system related</td><td>GQ INCREASED 0.24</td></tr><tr><td>703</td><td>ENSDARP00000092551</td><td>anxa11a</td><td>anxa11a-001</td><td>Annexin A11a</td><td>Immune system related</td><td>GQ INCREASED 0.24</td></tr><tr><td>704</td><td>ENSDARP00000052941</td><td>serpinh2</td><td>serpinh2</td><td>Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)</td><td>Other</td><td>GQ INCREASED 0.24</td></tr><tr><td>705</td><td>ENSDARP00000105167</td><td>serpinh2</td><td>serpinh2</td><td>Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)</td><td>Other</td><td>GQ INCREASED 0.24</td></tr><tr><td>706</td><td>ENSDARP00000125495</td><td>GBE1 (2 of 2)</td><td>GBE1 (2 of 2)-001</td><td>Glucan (1,4-alpha-), branching enzyme 1</td><td>Energy metabolism</td><td>GQ INCREASED 0.24</td></tr><tr><td>707</td><td>ENSDARP00000086805</td><td>myh9b</td><td>myh9b-201</td><td>Myosin, heavy polypeptide 9b, non-muscle</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED 0.24</td></tr><tr><td>708</td><td>ENSDARP00000114437</td><td>myh9b</td><td>myh9b-001</td><td>Myosin, heavy polypeptide 9b, non-muscle</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED 0.23</td></tr><tr><td>709</td><td>ENSDARP00000068053</td><td>tes</td><td>tes-201</td><td>Testis derived transcript (3 LIM domains)</td><td>Protein Synthesis</td><td>GQ INCREASED 0.23</td></tr><tr><td>710</td><td>ENSDARP00000111043</td><td>supt16h</td><td>supt16h-203</td><td>Suppressor of Ty 16 homolog (S. cerevisiae) (FACT complex subunit SPT16)</td><td>Protein Synthesis</td><td>GQ INCREASED 0.22</td></tr><tr><td>711</td><td>ENSDARP00000039188</td><td>lmf2b</td><td>lmf2b-201</td><td>Lipase maturation factor 2b</td><td>Protein Synthesis</td><td>GQ INCREASED 0.22</td></tr><tr><td>712</td><td>ENSDARP00000100277</td><td>supt16h</td><td>supt16h-201</td><td>Suppressor of Ty 16 homolog (S. cerevisiae) (FACT complex subunit SPT16)</td><td>Protein Synthesis</td><td>GQ INCREASED 0.22</td></tr><tr><td>713</td><td>ENSDARP00000109077</td><td>supt16h</td><td>supt16h-202</td><td>Suppressor of Ty 16 homolog (S. cerevisiae) (FACT complex subunit SPT16)</td><td>Protein Synthesis</td><td>GQ INCREASED 0.22</td></tr><tr><td>714</td><td>ENSDARP00000014578</td><td>gpb</td><td>gpb-201</td><td>Glucose phosphate isomerase b</td><td>Energy metabolism</td><td>GQ INCREASED 0.22</td></tr><tr><td>715</td><td>ENSDARP00000089816</td><td>atp6v1h</td><td>atp6v1h-201</td><td>V-type H+-transporting ATPase subunit H</td><td>Energy metabolism</td><td>GQ INCREASED 0.22</td></tr><tr><td>716</td><td>ENSDARP00000113453</td><td>atp6v1h</td><td>atp6v1h-002</td><td>V-type H+-transporting ATPase subunit H</td><td>Energy metabolism</td><td>GQ INCREASED 0.22</td></tr><tr><td>717</td><td>ENSDARP00000068054</td><td>tes</td><td>tes-001</td><td>Testis derived transcript (3 LIM domains)</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED 0.22</td></tr><tr><td>718</td><td>ENSDARP00000113128</td><td>arcn1b</td><td>arcn1b-002</td><td>Archain 1b</td><td>Other</td><td>GQ INCREASED 0.22</td></tr><tr><td>719</td><td>ENSDARP00000073441</td><td>cpvl</td><td>cpvl-001</td><td>Vitellogenic carboxypeptidase-like protein</td><td>Protein degradation and synthesis inhibition</td><td>GQ INCREASED 0.22</td></tr><tr><td>720</td><td>ENSDARP00000094422</td><td>si:ch211-160d14.1</td><td>si:ch211-160d14.1-001</td><td>Fascin</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED 0.22</td></tr><tr><td>721</td><td>ENSDARP00000024886</td><td>atp6v1h</td><td>atp6v1h-001</td><td>V-type H+-transporting ATPase subunit H</td><td>Energy metabolism</td><td>GQ INCREASED 0.22</td></tr><tr><td>722</td><td>ENSDARP00000074155</td><td>nie1</td><td>nie1-002</td><td>Notchless homolog 1 (Drosophila)</td><td>Protein Synthesis</td><td>GQ INCREASED 0.22</td></tr><tr><td>723</td><td>ENSDARP00000122687</td><td>nie1</td><td>nie1-001</td><td>Notchless homolog 1 (Drosophila)</td><td>Protein Synthesis</td><td>GQ INCREASED 0.22</td></tr><tr><td>724</td><td>ENSDARP00000083458</td><td>lap3</td><td>lap3-001</td><td>Leucine aminopeptidase 3</td><td>Protein degradation and synthesis inhibition</td><td>GQ INCREASED 0.22</td></tr><tr><td>725</td><td>ENSDARP00000058889</td><td>ephx2</td><td>ephx2-001</td><td>Epoxide hydrolase 2, cytoplasmic</td><td>Lipid metabolism</td><td>GQ INCREASED 0.20</td></tr><tr><td>726</td><td>ENSDARP00000117022</td><td>crabt</td><td>crabt-001</td><td>Carnitine O-acetyltransferase b</td><td>Energy metabolism</td><td>GQ INCREASED 0.20</td></tr><tr><td>727</td><td>ENSDARP00000129034</td><td>eml2</td><td>eml2-001</td><td>Echinoderm microtubule associated protein like 2</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED 0.20</td></tr><tr><td>728</td><td>ENSDARP00000080223</td><td>eml2</td><td>eml2-201</td><td>Echinoderm microtubule associated protein like 2</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED 0.20</td></tr><tr><td>729</td><td>ENSDARP00000101418</td><td>GBE1 (2 of 2)</td><td>GBE1 (2 of 2)-201</td><td>Glucan (1,4-alpha-), branching enzyme 1</td><td>Energy metabolism</td><td>GQ INCREASED 0.19</td></tr><tr><td>730</td><td>ENSDARP00000083382</td><td>fbxo10</td><td>fbxo10-001</td><td>F-box protein 10</td><td>Protein degradation and synthesis inhibition</td><td>GQ INCREASED 0.18</td></tr><tr><td>731</td><td>ENSDARP00000094289</td><td>cpne1</td><td>cpne1-202</td><td>Copine I</td><td>Other</td><td>GQ INCREASED 0.18</td></tr><tr><td>732</td><td>ENSDARP00000121695</td><td>si:ch211-93f2.1</td><td></td><td>Carboxylic ester hydrolase</td><td>REDOX/Detox related</td><td>GQ INCREASED 0.18</td></tr><tr><td>733</td><td>ENSDARP00000017582</td><td>zc3h15</td><td>zc3h15-001</td><td>Zinc finger CCCH-type containing 15</td><td>Protein Synthesis</td><td>GQ INCREASED 0.18</td></tr><tr><td>734</td><td>ENSDARP00000082086</td><td>cpne1</td><td>cpne1-201</td><td>Copine I</td><td>Other</td><td>GQ INCREASED 0.18</td></tr><tr><td>735</td><td>ENSDARP00000077445</td><td>scn41</td><td>scn41-001</td><td>Cytochrome c oxidase subunit IV isoform 1</td><td>Energy metabolism</td><td>GQ INCREASED 0.17</td></tr><tr><td>736</td><td>ENSDARP00000035261</td><td>pfd2n</td><td>pfd2n-001</td><td>Prefoldin subunit 2</td><td>Protein Synthesis</td><td>GQ INCREASED 0.17</td></tr><tr><td>737</td><td>ENSDARP00000068644</td><td>BX322787.1</td><td>BX322787.1-201</td><td>ATP-binding cassette, sub-family F, member 2-like</td><td>Protein Synthesis</td><td>GQ INCREASED 0.17</td></tr><tr><td>738</td><td>ENSDARP00000116994</td><td>ehd1a</td><td>ehd1a-002</td><td>Encapsin</td><td>Energy metabolism</td><td>GQ INCREASED 0.17</td></tr><tr><td>739</td><td>ENSDARP00000053867</td><td>aldh9a1b</td><td>aldh9a1b-001</td><td>Aldehyde dehydrogenase 9 family, member A1b</td><td>Lipid metabolism</td><td>GQ INCREASED 0.16</td></tr></tbody></table>
<table><tr><td>740</td><td>ENSDARP00000034052</td><td>pdc4a</td><td>pdc4a-201</td><td>Programmed cell death protein 4</td><td>Apoptosis related</td><td>GQ INCREASED</td><td>0.16</td></tr><tr><td>741</td><td>ENSDARP00000011311</td><td>arcn1a</td><td>arcn1a-001</td><td>Archain 1a</td><td>Other</td><td>GQ INCREASED</td><td>0.15</td></tr><tr><td>742</td><td>ENSDARP00000101190</td><td>RAP1GDS1</td><td>RAP1GDS1-201</td><td>RAP1, GTP-GDP dissociation stimulator 1</td><td>Other</td><td>GQ INCREASED</td><td>0.15</td></tr><tr><td>743</td><td>ENSDARP00000113140</td><td>larsb</td><td>larsb-001</td><td>Leucyl-tRNA synthetase b</td><td>Protein Synthesis</td><td>GQ INCREASED</td><td>0.15</td></tr><tr><td>744</td><td>ENSDARP0000004838</td><td>rcc2</td><td>rcc2-001</td><td>Regulator of chromosome condensation 2</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED</td><td>0.15</td></tr><tr><td>745</td><td>ENSDARP00000123019</td><td>zp3c</td><td>zp3c-001</td><td>Zona pellucida protein</td><td>Zona Pellucida proteins</td><td>GQ INCREASED</td><td>0.15</td></tr><tr><td>746</td><td>ENSDARP0000003359</td><td>larsb</td><td>larsb-201</td><td>Leucyl-tRNA synthetase b</td><td>Protein Synthesis</td><td>GQ INCREASED</td><td>0.14</td></tr><tr><td>747</td><td>ENSDARP00000011011</td><td>eiif3d</td><td>eiif3d-201</td><td>Eukaryotic translation initiation factor</td><td>Protein Synthesis</td><td>GQ INCREASED</td><td>0.12</td></tr><tr><td>748</td><td>ENSDARP00000112626</td><td>oct21a</td><td>oct21a-003</td><td>3-oxoacid CoA transferase 1a</td><td>Energy metabolism</td><td>GQ INCREASED</td><td>0.12</td></tr><tr><td>749</td><td>ENSDARP000000116681</td><td>eiif3d</td><td>eiif3d-001</td><td>Eukaryotic translation initiation factor</td><td>Protein Synthesis</td><td>GQ INCREASED</td><td>0.12</td></tr><tr><td>750</td><td>ENSDARP00000056839</td><td>abcf2a</td><td>abcf2a-001</td><td>ATP-binding cassette, sub-family F (GCN20), member 2a</td><td>Protein Synthesis</td><td>GQ INCREASED</td><td>0.12</td></tr><tr><td>751</td><td>ENSDARP000000116165</td><td>cltcb</td><td>cltcb-003</td><td>Clathrin, heavy polypeptide b</td><td>Protein degradation and synthesis inhibition</td><td>GQ INCREASED</td><td>0.12</td></tr><tr><td>752</td><td>ENSDARP0000003738</td><td>eno1a</td><td>eno1a-001</td><td>Enolase 1a</td><td>Energy metabolism</td><td>GQ INCREASED</td><td>0.12</td></tr><tr><td>753</td><td>ENSDARP00000047901</td><td>arcn1b</td><td>arcn1b-001</td><td>Archain 1b</td><td>Other</td><td>GQ INCREASED</td><td>0.12</td></tr><tr><td>754</td><td>ENSDARP00000020181</td><td>ehd1b</td><td>ehd1b-001</td><td>EH-domain containing 3</td><td>Protein degradation and synthesis inhibition</td><td>GQ INCREASED</td><td>0.11</td></tr><tr><td>755</td><td>ENSDARP00000051798</td><td>hdac1</td><td>hdac1-001</td><td>Histone deacetylase 1</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED</td><td>0.11</td></tr><tr><td>756</td><td>ENSDARP00000095265</td><td>si:ch211-93f2.1</td><td></td><td>Carboxylic ester hydrolase-esterase lipase sueprfamily-drug metabolism</td><td>REDOX/Detox related</td><td>GQ INCREASED</td><td>0.10</td></tr><tr><td>757</td><td>ENSDARP00000021016</td><td>zgc:158620</td><td></td><td>Novel</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>758</td><td>ENSDARP00000016957</td><td>rpI36</td><td>rpI36-001</td><td>Ribosomal protein L36</td><td>Protein Synthesis</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>759</td><td>ENSDARP000000124304</td><td>rpI36</td><td>rpI36-002</td><td>Ribosomal protein L36</td><td>Protein Synthesis</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>760</td><td>ENSDARP00000012767</td><td></td><td></td><td>Aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 2</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>761</td><td>ENSDARP00000118282</td><td>oct21a</td><td>oct21a-004</td><td>3-oxoacid CoA transferase 1a</td><td>Lipid metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>762</td><td>ENSDARP000000109625</td><td>tubb2</td><td>tubb2-001 (novel)</td><td>Beta tubulin</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>763</td><td>ENSDARP000000108663</td><td>CABZ01032488.1</td><td>CABZ01032488.1-201</td><td>Aldehyde dehydrogenase super family</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>764</td><td>ENSDARP000000110851</td><td>FP102463.1</td><td>FP102463.1-201</td><td>Beta tubulin</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>765</td><td>ENSDARP000000126192</td><td>eiif3d</td><td>eiif3d-004</td><td>Eukaryotic translation initiation factor 3, subunit D</td><td>Protein Synthesis</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>766</td><td>ENSDARP00000035541</td><td>ube21a</td><td>ube21a-201</td><td>Ubiquitin-conjugating enzyme E2L 3a</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>767</td><td>ENSDARP00000045555</td><td>pam16</td><td>pam16-001</td><td>Presequence translocase-associated motor 16 homolog (S. cerevisiae)</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>768</td><td>ENSDARP00000072006</td><td>tuba1c</td><td>tuba1c-001</td><td>Tubulin alpha 1c</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>769</td><td>ENSDARP00000016749</td><td>me2</td><td>me2-001</td><td>Malic enzyme 2, NAD(+)-dependent, mitochondrial</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>770</td><td>ENSDARP000000109682</td><td>me2</td><td>me2-201</td><td>Malic enzyme 2, NAD(+)-dependent, mitochondrial</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>771</td><td>ENSDARP000000127763</td><td>HIST1H2BA (9 of 9)</td><td>HIST1H2BA (9 of 9)-001</td><td>Histone</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>772</td><td>ENSDARP00000115350</td><td>aidh9a1b</td><td>aidh9a1b-002</td><td>Aldehyde dehydrogenase 9 family, member A1b</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>773</td><td>ENSDARP00000088020</td><td>aidh2.2</td><td>aidh2.2-202</td><td>Aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 2</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>774</td><td>ENSDARP00000088019</td><td>aidh2.2</td><td>aidh2.2-201</td><td>Aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 2</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>775</td><td>ENSDARP000000105094</td><td>tuba1b</td><td>tuba1b-001</td><td>Tubulin alpha 1b</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>776</td><td>ENSDARP00000083766</td><td>dak</td><td>dak-001</td><td>Dihydroxyacetone kinase 2 homolog (S. cerevisiae)</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>777</td><td>ENSDARP00000055448</td><td>pkma</td><td>pkma-202</td><td>Pyruvate kinase, muscle, a</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>778</td><td>ENSDARP000000105213</td><td>CABZ01112387.1</td><td>CABZ01112387.1-201</td><td>Myosin 9 like-myosin N super family</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>779</td><td>ENSDARP00000009846</td><td>arf1</td><td>arf1-201</td><td>ADP-ribosylation factor 1</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>780</td><td>ENSDARP000000102498</td><td>arf1</td><td>arf1-202</td><td>ADP-ribosylation factor 1</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>781</td><td>ENSDARP000000128933</td><td>ppp5c</td><td>ppp5c-001</td><td>Protein phosphatase 5, catalytic subunit</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>782</td><td>ENSDARP000000110687</td><td>LOC101884557</td><td></td><td>Myosin 9 like-myosin N super family</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>783</td><td>ENSDARP000000124733</td><td>me2</td><td>me2-002</td><td>Malic enzyme 2, NAD(+)-dependent, mitochondrial</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>784</td><td>ENSDARP000000114018</td><td>prmt3</td><td>prmt3-002</td><td>Protein arginine methyltransferase 3</td><td>Protein Synthesis</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>785</td><td>ENSDARP00000003829</td><td>prmt3</td><td>prmt3-001</td><td>Protein arginine methyltransferase 3</td><td>Protein Synthesis</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>786</td><td>ENSDARP000000122171</td><td>rpI8</td><td>rpI8-002</td><td>Ribosomal protein L8</td><td>Protein Synthesis</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>787</td><td>ENSDARP000000104932</td><td>sh3d21</td><td>Novel</td><td>Uncharacterized protein-SH3 domain-containing protein 21</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>788</td><td>ENSDARP00000058636</td><td>sh3d21</td><td>Novel</td><td>Uncharacterized protein-SH3 domain-containing protein 21</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>789</td><td>ENSDARP00000062517</td><td>zgc:162356</td><td>zgc:162356-001</td><td>Glutathione S-transferase-glutathione metabolism-xenobiotics biodegradation and metabolism</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>790</td><td>ENSDARP000000104897</td><td>dbn1b</td><td>dbn1b-202</td><td>Drebrin-like b</td><td>Endosome-Lysosome related</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>791</td><td>ENSDARP000000112697</td><td>sh3d21</td><td>Novel</td><td>Uncharacterized protein-SH3 domain-containing protein 21</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>792</td><td>ENSDARP000000122208</td><td>ERAP1 (2 of 2)</td><td>ERAP1 (2 of 2)-201</td><td>Endoplasmic reticulum aminopeptidase 1</td><td>Immune system related</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>793</td><td>ENSDARP00000095260</td><td>cox412</td><td>cox412-001</td><td>Cytochrome c oxidase subunit IV isoform 2</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>794</td><td>ENSDARP00000066122</td><td>KPN6A</td><td>KPN6A-201</td><td>Karyopherin alpha 6 (importin alpha 7</td><td>Protein Synthesis</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>795</td><td>ENSDARP000000117154</td><td>dnpep</td><td>dnpep-003</td><td>Aspartyl aminopeptidase</td><td>Protein degradation and synthesis inhibition</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>796</td><td>ENSDARP000000113894</td><td>hars</td><td>hars-002</td><td>Histidyl-tRNA synthetase</td><td>Protein Synthesis</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>797</td><td>ENSDARP00000051468</td><td>si:ch211-186e20.7</td><td>si:ch211-186e20.7-201</td><td>Serpin super family-alpha antitrypsin domain</td><td>Other</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>798</td><td>ENSDARP000000123705</td><td>si:ch211-186e20.7</td><td>si:ch211-186e20.7-001</td><td>Serpin super family-alpha antitrypsin domain</td><td>Other</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>799</td><td>ENSDARP000000114386</td><td>eno2</td><td>eno2-003</td><td>Enolase 2</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>800</td><td>ENSDARP000000117079</td><td>sh3d21</td><td>Novel</td><td>Uncharacterized protein-SH3 domain-containing protein 21</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>801</td><td>ENSDARP000000124373</td><td>atp6v1h</td><td>atp6v1h-004</td><td>ATPase, H+ transporting, lysosomal, V1 subunit H</td><td>Endosome-Lysosome related</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>802</td><td>ENSDARP00000027911</td><td>dbn1b</td><td>dbn1b-201</td><td>Drebrin-like b</td><td>Endosome-Lysosome related</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>803</td><td>ENSDARP00000014921</td><td>zgc:92137</td><td>zgc:92137-201</td><td>alpha amylase</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>804</td><td>ENSDARP00000038575</td><td>dhdi</td><td>dhdi-001</td><td>Dihydrodialdehyde dehydrogenase (dimeric), like</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>805</td><td>ENSDARP00000008466</td><td>hpx</td><td>hpx-201</td><td>Hemopexin</td><td>Other</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>806</td><td>ENSDARP000000111337</td><td>hpx</td><td>hpx-001</td><td>Hemopexin</td><td>Other</td><td>GQ UNIQUE</td><td>-</td></tr><tr><td>807</td><td>ENSDARP00000052498</td><td>gle</td><td>gle-201</td><td>Galactosidase, alpha</td><td>Lipid metabolism</td><td>GQ UNIQUE</td><td>-</td></tr></table>
<table><thead><tr><th></th><th></th><th></th><th></th><th></th><th></th><th></th></tr></thead><tbody><tr><td>876</td><td>ENSDARP00000124518</td><td>anxa6</td><td>anxa6-001</td><td>Annexin A6</td><td>Endosome-Lysosome related</td><td>GQ UNIQUE</td></tr><tr><td>877</td><td>ENSDARP0000014963</td><td>ppp2r5cb</td><td>ppp2r5cb-201</td><td>Protein phosphatase 2, regulatory subunit B, gamma b</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td></tr><tr><td>878</td><td>ENSDARP00000101961</td><td>ppp2r5cb</td><td>ppp2r5cb-202</td><td>Protein phosphatase 2, regulatory subunit B, gamma b</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td></tr><tr><td>879</td><td>ENSDARP00000103928</td><td>ppp2r5cb</td><td>ppp2r5cb-001</td><td>Protein phosphatase 2, regulatory subunit B, gamma b</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td></tr><tr><td>880</td><td>ENSDARP00000012056</td><td>ctps1b</td><td>ctps1b-001</td><td>CTP synthase 1b</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td></tr><tr><td>881</td><td>ENSDARP000000028051</td><td>lmnl3</td><td>lmnl3-001</td><td>Lamin L3</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td></tr><tr><td>882</td><td>ENSDARP000000070709</td><td>ctps1b</td><td>ctps1b-201</td><td>CTP synthase 1b</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td></tr><tr><td>883</td><td>ENSDARP000000092744</td><td>me1</td><td>me1-002</td><td>Malic enzyme 1, NADP(+)-dependent, cytosolic</td><td>Energy metabolism</td><td>GQ UNIQUE</td></tr><tr><td>884</td><td>ENSDARP000000113885</td><td>me1</td><td>me1-001</td><td>Malic enzyme 1, NADP(+)-dependent, cytosolic</td><td>Energy metabolism</td><td>GQ UNIQUE</td></tr><tr><td>885</td><td>ENSDARP000000120790</td><td>kpna1</td><td>kpna1-001</td><td>Karyopherin alpha 1 (importin alpha 5)</td><td>Protein Synthesis</td><td>GQ UNIQUE</td></tr><tr><td>886</td><td>ENSDARP000000091935</td><td>impdh1a</td><td>impdh1a-201</td><td>Inosine 5-phosphate dehydrogenase 1a</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td></tr><tr><td>887</td><td>ENSDARP000000051917</td><td>PARP14</td><td>PARP14-201</td><td>Poly (ADP-ribose) polymerase family, member 14</td><td>Apoptosis related</td><td>GQ UNIQUE</td></tr><tr><td>888</td><td>ENSDARP000000016922</td><td>aglb</td><td>aglb-001</td><td>Arnt/lo-1, 6-glucosidase, 4-alpha-glucanotransferase b</td><td>Energy metabolism</td><td>GQ UNIQUE</td></tr><tr><td>889</td><td>ENSDARP000000098492</td><td>zfat</td><td>zfat-201</td><td>Zinc finger and AT hook domain containing</td><td>Protein Synthesis</td><td>GQ UNIQUE</td></tr><tr><td>890</td><td>ENSDARP000000127519</td><td>zfat</td><td>zfat-001</td><td>Zinc finger and AT hook domain containing</td><td>Protein Synthesis</td><td>GQ UNIQUE</td></tr><tr><td>891</td><td>ENSDARP000000025533</td><td>tln1</td><td>tln1-201</td><td>Talin 1</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td></tr><tr><td>892</td><td>ENSDARP000000072597</td><td>tln1</td><td>tln1-001</td><td>Talin 1</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td></tr></tbody></table>
<table><caption>**S2 Table. Proteins differentially regulated in the Multiple Samples Experiment.** List of the 274 proteins from the Multiple Samples Experiment that were considered to be differentially regulated between egg quality groups and whose distribution among various functional categories is illustrated in Fig 2b. These include proteins detected only in poor quality eggs (PQ UNIQUE, n=93), proteins in poor quality eggs with N-SC increased ≥2-fold relative to values for good quality eggs (PQ INCREASED, n=58), proteins detected only in good quality eggs (GQ UNIQUE, n=90), and proteins in good quality eggs with N-SC increased ≥2-fold relative to values for poor quality eggs (GQ INCREASED, n=32). For each protein, the Ensembl Protein ID and associated gene, transcript and protein name, functional category (see Fig 2b), regulation (UNIQUE or INCREASED), fold-difference in N-SC between egg quality groups (if available), and fraction in which the protein was originally detected (LMW, low molecular weight; HMW, high molecular weight) is shown. Color shading corresponds to that used to designate functional categories in Fig 2.</caption><thead><tr><th>ENSEMBL Protein ID</th><th>Associated Gene Name</th><th>Associated Transcript Name</th><th>Protein Full Name</th><th>Functional Category</th><th>Regulation</th><th>Fold Difference</th><th>Fraction</th></tr></thead><tbody><tr><td>1</td><td>ENSDARP00000043192</td><td>si:ch211-161h7.6</td><td>si:ch211-161h7.6-002</td><td>cst14a.2</td><td>Other</td><td>-</td><td>LMW</td></tr><tr><td>2</td><td>ENSDARP00000121287</td><td>si:ch211-161h7.6</td><td>si:ch211-161h7.6-001</td><td>cst14a.2</td><td>Other</td><td>-</td><td>LMW</td></tr><tr><td>3</td><td>ENSDARP00000053567</td><td>day1b</td><td>day1b-201</td><td>Death associated protein 1b</td><td>Apoptosis related</td><td>-</td><td>LMW</td></tr><tr><td>4</td><td>ENSDARP00000109203</td><td>day1b</td><td>day1b-202</td><td>Death associated protein b-apoptotic signaling pathway</td><td>Apoptosis related</td><td>-</td><td>LMW</td></tr><tr><td>5</td><td>ENSDARP00000022120</td><td>rab7</td><td>rab7-001</td><td>RAB7, member RAS oncogene family</td><td>Endosome-Lysosome related</td><td>-</td><td>LMW</td></tr><tr><td>6</td><td>ENSDARP00000113451</td><td>si:dkeyp-20e4.8</td><td>si:dkeyp-20e4.8-001</td><td>Uncharacterized protein</td><td>Other</td><td>-</td><td>LMW</td></tr><tr><td>7</td><td>ENSDARP00000069977</td><td>rpl23</td><td>rpl23-001</td><td>Ribosomal protein L23</td><td>Protein synthesis</td><td>-</td><td>LMW</td></tr><tr><td>8</td><td>ENSDARP00000112856</td><td>rpl30</td><td>rpl30-002</td><td>Ribosomal protein L30</td><td>Protein synthesis</td><td>-</td><td>LMW</td></tr><tr><td>9</td><td>ENSDARP00000052081</td><td>rpl30</td><td>rpl30-001</td><td>Ribosomal protein L30</td><td>Protein synthesis</td><td>-</td><td>LMW</td></tr><tr><td>10</td><td>ENSDARP00000025539</td><td>Rab7-like, rab7b</td><td>Rab7-like, rab7b</td><td>Rab7-like, rab7b</td><td>Endosome-Lysosome related</td><td>-</td><td>LMW</td></tr><tr><td>11</td><td>ENSDARP00000106613</td><td>Rab7-like</td><td>Rab7-like</td><td>Rab7-like</td><td>Endosome-Lysosome related</td><td>-</td><td>LMW</td></tr><tr><td>12</td><td>ENSDARP00000118883</td><td>apom</td><td>apom-002</td><td>Apolipoprotein M</td><td>Immune system related</td><td>-</td><td>LMW</td></tr><tr><td>13</td><td>ENSDARP00000103118</td><td>zgc:100918</td><td>Novel transcript</td><td>Uncharacterized protein-Rab7-like, ras-related, protein</td><td>Endosome-Lysosome related</td><td>-</td><td>LMW</td></tr><tr><td>14</td><td>ENSDARP00000111138</td><td>zgc:100918</td><td>Novel transcript</td><td>Uncharacterized protein-Rab7a-like, ras-related, protein</td><td>Endosome-Lysosome related</td><td>-</td><td>LMW</td></tr><tr><td>15</td><td>ENSDARP00000122132</td><td>apom</td><td>apom-003</td><td>Apolipoprotein M</td><td>Immune system related</td><td>-</td><td>LMW</td></tr><tr><td>16</td><td>ENSDARP00000016540</td><td>rab11a1</td><td>rab11a1-001</td><td>RAB11a, member RAS oncogene family, like</td><td>Endosome-Lysosome related</td><td>-</td><td>LMW</td></tr><tr><td>17</td><td>ENSDARP00000123136</td><td>apom</td><td>apom-001</td><td>Apolipoprotein M</td><td>Immune system related</td><td>-</td><td>LMW</td></tr><tr><td>18</td><td>ENSDARP00000128683</td><td>ACTC1 (2 of 2)</td><td>ACTC1 (2 of 2)-001</td><td>Actin, alpha, cardiac muscle 1a</td><td>Cell cycle, division, growth and fate</td><td>-</td><td>LMW</td></tr><tr><td>19</td><td>ENSDARP00000030257</td><td>si:ch211-226h8.8</td><td>si:ch211-226h8.8-201</td><td>Uncharacterized protein containing SUEL type lectin domain</td><td>Lectins</td><td>-</td><td>LMW</td></tr><tr><td>20</td><td>ENSDARP00000036607</td><td>fkbp1aa</td><td>fkbp1aa-001</td><td>FK506 binding protein 1Aa</td><td>Protein synthesis</td><td>-</td><td>LMW</td></tr><tr><td>21</td><td>ENSDARP00000119718</td><td>fkbp1aa</td><td>fkbp1aa-003</td><td>FK506 binding protein 1Aa</td><td>Protein synthesis</td><td>-</td><td>LMW</td></tr><tr><td>22</td><td>ENSDARP00000123671</td><td>fkbp1aa</td><td>fkbp1aa-002</td><td>FK506 binding protein 1Aa</td><td>Protein synthesis</td><td>-</td><td>LMW</td></tr><tr><td>23</td><td>ENSDARP00000075918</td><td>sri</td><td>sri-001</td><td>Sorcin</td><td>Protein degradation and synthesis inhibition</td><td>-</td><td>LMW</td></tr><tr><td>24</td><td>ENSDARP00000113274</td><td>si:ch211-226h8.8</td><td>si:ch211-226h8.8-001</td><td>Uncharacterized protein-Gal lectin superfamily</td><td>Lectins</td><td>-</td><td>LMW</td></tr><tr><td>25</td><td>ENSDARP00000121868</td><td>zgc:172218</td><td>Novel transcript</td><td>Uncharacterized protein containing 3SUEL type lectin domains</td><td>L-rhamnose-binding lectin CSL3-like isoform X1</td><td>-</td><td>LMW</td></tr><tr><td>26</td><td>ENSDARP00000117390</td><td>si:ch211-226h8.11</td><td>si:ch211-226h8.11-001</td><td>L-rhamnose-binding lectin CSL3-like isoform X1</td><td>Lectins</td><td>-</td><td>LMW</td></tr><tr><td>27</td><td>ENSDARP00000037689</td><td>ITIH4</td><td>ITIH4-201</td><td>Inter-alpha-trypsin inhibitor heavy chain family member 4</td><td>Other</td><td>-</td><td>LMW</td></tr><tr><td>28</td><td>ENSDARP00000059193</td><td>snrpd2</td><td>snrpd2-001</td><td>Small nuclear ribonucleoprotein D2 polypeptide</td><td>Protein synthesis</td><td>-</td><td>LMW</td></tr><tr><td>29</td><td>ENSDARP00000069885</td><td>rpl31</td><td>rpl31-201</td><td>Ribosomal protein L31</td><td>Protein synthesis</td><td>-</td><td>LMW</td></tr><tr><td>30</td><td>ENSDARP00000123730</td><td>rpl31</td><td>rpl31-002</td><td>Ribosomal protein L31</td><td>Protein synthesis</td><td>-</td><td>LMW</td></tr><tr><td>31</td><td>ENSDARP00000124804</td><td>rpl31</td><td>rpl31-001</td><td>Ribosomal protein L31</td><td>Protein synthesis</td><td>-</td><td>LMW</td></tr><tr><td>32</td><td>ENSDARP00000116530</td><td>snx3</td><td>snx3-003</td><td>Sorting nexin 3</td><td>Endosome-Lysosome related</td><td>-</td><td>LMW</td></tr><tr><td>33</td><td>ENSDARP00000120388</td><td>actb2</td><td>actb2-002</td><td>Actin, beta 2</td><td>Cell cycle, division, growth and fate</td><td>-</td><td>LMW</td></tr><tr><td>34</td><td>ENSDARP00000116418</td><td>actb1</td><td>actb1-002</td><td>Actin, beta 1</td><td>Cell cycle, division, growth and fate</td><td>-</td><td>LMW</td></tr><tr><td>35</td><td>ENSDARP00000107711</td><td>CABZ201044980.1</td><td>CABZ201044980.1-201</td><td>Zona pellucida sperm-binding protein 3-like precursor</td><td>Zona Pellucida proteins</td><td>-</td><td>LMW</td></tr><tr><td>36</td><td>ENSDARP00000115342</td><td>park7</td><td>park7-002</td><td>Parkinson protein 7</td><td>REDOX/Detox related</td><td>-</td><td>LMW</td></tr><tr><td>37</td><td>ENSDARP00000012094</td><td>snx3</td><td>snx3-001</td><td>Sorting nexin 3</td><td>Endosome-Lysosome related</td><td>-</td><td>LMW</td></tr><tr><td>38</td><td>ENSDARP00000104879</td><td>cp</td><td>cp-002</td><td>Ceruloplasmin</td><td>REDOX/Detox related</td><td>-</td><td>LMW</td></tr><tr><td>39</td><td>ENSDARP00000106910</td><td>cp</td><td>cp-003</td><td>Ceruloplasmin</td><td>REDOX/Detox related</td><td>-</td><td>LMW</td></tr><tr><td>40</td><td>ENSDARP00000067432</td><td>ube2nb</td><td>ube2nb-001</td><td>Ubiquitin-conjugating enzyme E2nb</td><td>Protein degradation and synthesis inhibition</td><td>-</td><td>LMW</td></tr><tr><td>41</td><td>ENSDARP00000038063</td><td>lect2l</td><td>lect2l-001</td><td>Leukocyte cell-derived chemotaxin 2 like</td><td>Immune system related</td><td>-</td><td>LMW</td></tr><tr><td>42</td><td>ENSDARP00000095287</td><td>cp</td><td>cp-202</td><td>Ceruloplasmin</td><td>REDOX/Detox related</td><td>-</td><td>LMW</td></tr><tr><td>43</td><td>ENSDARP00000119305</td><td>cdh1</td><td>cdh1-001</td><td>Cadherin 1, type 1, E-cadherin (epithelial)</td><td>Cell cycle, division, growth and fate</td><td>-</td><td>LMW</td></tr><tr><td>44</td><td>ENSDARP00000117259</td><td>MFAP4 (12 of 14)</td><td>MFAP4 (12 of 14)-201</td><td>Microfibrillar-associated protein 4</td><td>Cell cycle, division, growth and fate</td><td>-</td><td>LMW</td></tr><tr><td>45</td><td>ENSDARP00000088490</td><td>cdh1</td><td>cdh1-201</td><td>Cadherin 1, type 1, E-cadherin (epithelial)</td><td>Cell cycle, division, growth and fate</td><td>-</td><td>LMW</td></tr><tr><td>46</td><td>ENSDARP00000095385</td><td>cp</td><td>cp-201</td><td>Ceruloplasmin</td><td>REDOX/Detox related</td><td>-</td><td>LMW</td></tr><tr><td>47</td><td>ENSDARP00000117207</td><td>CU469531.2</td><td>CU469531.2-201</td><td>Small GTPase mediated signal transduction-protein transport</td><td>Other</td><td>-</td><td>LMW</td></tr><tr><td>48</td><td>ENSDARP00000129339</td><td>cdc42</td><td>cdc42-001</td><td>Cell division cycle 42</td><td>Cell cycle, division, growth and fate</td><td>-</td><td>LMW</td></tr><tr><td>49</td><td>ENSDARP00000062517</td><td>zgc:162356</td><td>zgc:162356-001</td><td>Glutathione S-transferase rho</td><td>REDOX/Detox related</td><td>-</td><td>LMW</td></tr><tr><td>50</td><td>ENSDARP00000052837</td><td>acta1a</td><td>acta1a-001</td><td>Actin alpha 1a skeletal muscle</td><td>Cell cycle, division, growth and fate</td><td>-</td><td>LMW</td></tr><tr><td>51</td><td>ENSDARP00000055135</td><td>actc1b</td><td>actc1b-201</td><td>Actin, alpha, cardiac muscle 1b</td><td>Cell cycle, division, growth and fate</td><td>-</td><td>LMW</td></tr><tr><td>52</td><td>ENSDARP00000058628</td><td>acta1b</td><td>acta1b-001</td><td>Actin, alpha 1b, skeletal muscle</td><td>Cell cycle, division, growth and fate</td><td>-</td><td>LMW</td></tr><tr><td>53</td><td>ENSDARP00000022550</td><td>ywhaqb</td><td>ywhaqb-001</td><td>Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b</td><td>REDOX/Detox related</td><td>-</td><td>LMW</td></tr></tbody></table>
<table><thead><tr><th></th><th></th><th></th><th></th><th></th><th></th><th></th><th></th><th></th><th></th></tr></thead><tbody><tr><td>54</td><td>ENSDARP00000062382</td><td>ywhaga</td><td>ywhaga-001</td><td>Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b</td><td>REDOX/Detox related</td><td>PQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>55</td><td>ENSDARP00000074935</td><td>ywhag1</td><td>ywhag1-001</td><td>3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1</td><td>Cell cycle, division, growth and fate</td><td>PQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>56</td><td>ENSDARP00000096898</td><td>ywhag2</td><td>ywhag2-001</td><td>3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2</td><td>Cell cycle, division, growth and fate</td><td>PQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>57</td><td>ENSDARP00000040421</td><td>bhmt</td><td>bhmt-201</td><td>Betaine-homocysteine methyltransferase</td><td>Other</td><td>PQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>58</td><td>ENSDARP00000104071</td><td>f2</td><td>f2-002</td><td>Coagulation factor II (thrombin)</td><td>Immune system related</td><td>PQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>59</td><td>ENSDARP00000052324</td><td>f2</td><td>f2-001</td><td>Coagulation factor II (thrombin)</td><td>Immune system related</td><td>PQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>60</td><td>ENSDARP00000015293</td><td>cp</td><td>cp-001</td><td>Ceruloplasmin</td><td>REDOX/Detox related</td><td>PQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>61</td><td>ENSDARP00000109575</td><td>si:ch1073-263o8.2</td><td>si:ch1073-263o8.2-201</td><td>Uncharacterized protein</td><td>Other</td><td>PQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>62</td><td>ENSDARP00000125992</td><td>si:ch1073-263o8.2</td><td>si:ch1073-263o8.2-001</td><td>Uncharacterized protein</td><td>Other</td><td>PQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>63</td><td>ENSDARP0000102472</td><td>vtg4</td><td>vtg4-202</td><td>Vitellogenin 4</td><td>Vitellogenins</td><td>PQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>64</td><td>ENSDARP00000103251</td><td>qdprb2</td><td>qdprb2-201</td><td>Quinoid dihydropteridine reductase b2</td><td>REDOX/Detox related</td><td>PQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>65</td><td>ENSDARP00000104702</td><td>qdprb2</td><td>qdprb2-001</td><td>Quinoid dihydropteridine reductase b2</td><td>REDOX/Detox related</td><td>PQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>66</td><td>ENSDARP00000005402</td><td>zgc:173556</td><td>zgc:173556-201</td><td>Zona pellucida protein superfamily</td><td>Zona Pellucida proteins</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>67</td><td>ENSDARP00000010482</td><td>ybx1</td><td>ybx1-001</td><td>Y box binding protein 1</td><td>Protein synthesis</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>68</td><td>ENSDARP00000016831</td><td>cct6a</td><td>cct6a-201</td><td>Chaperonin containing TCP1, subunit 6A (zeta 1)</td><td>Protein synthesis</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>69</td><td>ENSDARP00000059040</td><td>h1m</td><td>h1m-201</td><td>Linker histone H1M</td><td>Cell cycle, division, growth and fate</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>70</td><td>ENSDARP00000061743</td><td>zp3a.1</td><td>zp3a.1-001</td><td>Zona pellucida glycoprotein 3a, tandem duplicate 1</td><td>Zona Pellucida proteins</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>71</td><td>ENSDARP00000067534</td><td>cap2</td><td>cap2-201</td><td>CAP, adenylate cyclase-associated protein, 2 (yeast)</td><td>Cell cycle, division, growth and fate</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>72</td><td>ENSDARP00000068662</td><td>zp3.2</td><td>zp3.2-202</td><td>Zona pellucida glycoprotein 3, tandem duplicate 2</td><td>Zona Pellucida proteins</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>73</td><td>ENSDARP00000068670</td><td>zgc:173556</td><td>zgc:173556-203</td><td>Zona pellucida protein superfamily</td><td>Zona Pellucida proteins</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>74</td><td>ENSDARP00000095894</td><td>sidkey-90123.2</td><td>Novel transcript</td><td>L-rhamnose-binding lectin CSL3-like isoform X2</td><td>Lectins</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>75</td><td>ENSDARP00000098884</td><td>ZP2 (3 of 4)</td><td>ZP2 (3 of 4)-201</td><td>Zona pellucida glycoprotein 2 (sperm receptor)</td><td>Zona Pellucida proteins</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>76</td><td>ENSDARP00000101517</td><td>ybx1</td><td>ybx1-201</td><td>Y box binding protein 1</td><td>Protein synthesis</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>77</td><td>ENSDARP00000105615</td><td>CU695117.1</td><td>CU695117.1-201</td><td>Zinc finger MYM-type protein 1</td><td>Protein synthesis</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>78</td><td>ENSDARP00000105815</td><td>zgc:173556</td><td>zgc:173556-001</td><td>Zona pellucida glycoprotein 3.1</td><td>Zona Pellucida proteins</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>79</td><td>ENSDARP00000107790</td><td>zp3a.1</td><td>zp3a.1-201</td><td>Zona pellucida glycoprotein 3a, tandem duplicate 1</td><td>Zona Pellucida proteins</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>80</td><td>ENSDARP00000107948</td><td>CU467646.1</td><td>CU467646.1-201</td><td>Mucin-5B-like isoform X5</td><td>Other</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>81</td><td>ENSDARP00000109119</td><td>zp3.2</td><td>zp3.2-201</td><td>Zona pellucida protein superfamily</td><td>Zona Pellucida proteins</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>82</td><td>ENSDARP00000109275</td><td>CU929506.1</td><td>CU929506.1-201</td><td>Zinc finger MYM-type protein 1</td><td>Protein synthesis</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>83</td><td>ENSDARP00000112608</td><td>cct6a</td><td>cct6a-002</td><td>Chaperonin containing TCP1, subunit 6A (zeta 1)</td><td>Protein synthesis</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>84</td><td>ENSDARP00000116487</td><td>zgc:165339</td><td>zgc:165339-002</td><td>Mucin-5AC</td><td>Other</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>85</td><td>ENSDARP00000118006</td><td>cct6a</td><td>cct6a-001</td><td>Chaperonin containing TCP1, subunit 6A (zeta 1)</td><td>Protein synthesis</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>86</td><td>ENSDARP00000118276</td><td>sidkey-90123.1</td><td>Novel transcript</td><td>SUEL type lectin domain</td><td>Lectins</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>87</td><td>ENSDARP00000021016</td><td>tubb2</td><td>Novel transcript</td><td>Tubulin beta 2</td><td>Cell cycle, division, growth and fate</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>88</td><td>ENSDARP00000055379</td><td>tubb5</td><td>tubb5-201</td><td>Tubulin beta 5</td><td>Cell cycle, division, growth and fate</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>89</td><td>ENSDARP00000095074</td><td>cno</td><td>cno-201</td><td>2'3'-cyclic nucleotide 3' phosphodiesterase</td><td>Cell cycle, division, growth and fate</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>90</td><td>ENSDARP00000102472</td><td>vtg4</td><td>vtg4-202</td><td>Vitellogenin 4</td><td>Vitellogenins</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>91</td><td>ENSDARP00000109625</td><td>tubb2</td><td>Novel transcript</td><td>Tubulin beta 2A chain</td><td>Cell cycle, division, growth and fate</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>92</td><td>ENSDARP00000110851</td><td>FP102463.1</td><td>FP102463.1-201</td><td>Tubulin</td><td>Cell cycle, division, growth and fate</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>93</td><td>ENSDARP00000110955</td><td>zgc:123194</td><td>zgc:123194-001</td><td>Tubulin</td><td>Cell cycle, division, growth and fate</td><td>PQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>94</td><td>ENSDARP00000062142</td><td>ARF5 (1 of 2)</td><td>ARF5 (1 of 2)-001</td><td>ADP-ribosylation factor 5</td><td>Endosome-Lysosome related</td><td>PQ INCREASED</td><td>7.06</td><td>LMW</td></tr><tr><td>95</td><td>ENSDARP00000094243</td><td>arf5</td><td>arf5-201</td><td>ADP-ribosylation factor 5</td><td>Endosome-Lysosome related</td><td>PQ INCREASED</td><td>7.06</td><td>LMW</td></tr><tr><td>96</td><td>ENSDARP00000116010</td><td>vtg7</td><td>vtg7-002</td><td>Vitellogenin 7</td><td>Vitellogenins</td><td>PQ INCREASED</td><td>7.00</td><td>LMW</td></tr><tr><td>97</td><td>ENSDARP00000115259</td><td>actb1</td><td>actb1-004</td><td>Actin beta 1</td><td>Cell cycle, division, growth and fate</td><td>PQ INCREASED</td><td>6.85</td><td>LMW</td></tr><tr><td>98</td><td>ENSDARP00000112639</td><td>actb1</td><td>actb1-005</td><td>Actin, beta 1</td><td>Cell cycle, division, growth and fate</td><td>PQ INCREASED</td><td>6.81</td><td>LMW</td></tr><tr><td>99</td><td>ENSDARP00000111487</td><td>rp122</td><td>rp122-001</td><td>Ribosomal protein L22</td><td>Protein synthesis</td><td>PQ INCREASED</td><td>5.90</td><td>LMW</td></tr><tr><td>100</td><td>ENSDARP00000067606</td><td>arf4a</td><td>arf4a-202</td><td>ADP-ribosylation factor 4a</td><td>Cell cycle, division, growth and fate</td><td>PQ INCREASED</td><td>5.16</td><td>LMW</td></tr><tr><td>101</td><td>ENSDARP00000067603</td><td>arf4a</td><td>arf4a-201</td><td>ADP-ribosylation factor 4a</td><td>Cell cycle, division, growth and fate</td><td>PQ INCREASED</td><td>5.10</td><td>LMW</td></tr><tr><td>102</td><td>ENSDARP00000067677</td><td>zgc:110339</td><td>zgc:110339-001</td><td>Uncharacterized</td><td>REDOX/Detox related</td><td>PQ INCREASED</td><td>4.24</td><td>LMW</td></tr><tr><td>103</td><td>ENSDARP00000046181</td><td>gstm3</td><td>gstm3-001</td><td>Glutathione S-transferase M3 (brain)</td><td>REDOX/Detox related</td><td>PQ INCREASED</td><td>3.20</td><td>LMW</td></tr><tr><td>104</td><td>ENSDARP00000054986</td><td>actb1</td><td>actb1-001</td><td>Actin beta 1</td><td>Cell cycle, division, growth and fate</td><td>PQ INCREASED</td><td>3.13</td><td>LMW</td></tr><tr><td>105</td><td>ENSDARP00000055193</td><td>actb2</td><td>actb2-007</td><td>Actin beta 2</td><td>Cell cycle, division, growth and fate</td><td>PQ INCREASED</td><td>3.13</td><td>LMW</td></tr><tr><td>106</td><td>ENSDARP00000122263</td><td>actb2</td><td>actb2-001</td><td>Actin beta 2</td><td>Cell cycle, division, growth and fate</td><td>PQ INCREASED</td><td>3.13</td><td>LMW</td></tr><tr><td>107</td><td>ENSDARP00000116310</td><td>ube2i3b</td><td>ube2i3b-002</td><td>Ubiquitin-conjugating enzyme E2L 3b</td><td>Protein degradation and synthesis inhibition</td><td>PQ INCREASED</td><td>3.07</td><td>LMW</td></tr><tr><td>108</td><td>ENSDARP00000035541</td><td>ube2i3a</td><td>ube2i3a-201</td><td>Ubiquitin-conjugating enzyme E2L 3a</td><td>Protein degradation and synthesis inhibition</td><td>PQ INCREASED</td><td>3.06</td><td>LMW</td></tr><tr><td>109</td><td>ENSDARP00000008064</td><td>ube2i3b</td><td>ube2i3b-003</td><td>Ubiquitin-conjugating enzyme E2L 3b</td><td>Protein degradation and synthesis inhibition</td><td>PQ INCREASED</td><td>3.05</td><td>LMW</td></tr><tr><td>110</td><td>ENSDARP00000090376</td><td>ube2i3b</td><td>ube2i3b-001</td><td>Ubiquitin-conjugating enzyme E2L 3b</td><td>Protein degradation and synthesis inhibition</td><td>PQ INCREASED</td><td>3.05</td><td>LMW</td></tr><tr><td>111</td><td>ENSDARP00000032643</td><td>zgc:56530</td><td>zgc:56530-001</td><td>MGC174082 protein-mRNA</td><td>Other</td><td>PQ INCREASED</td><td>3.04</td><td>LMW</td></tr><tr><td>112</td><td>ENSDARP00000035513</td><td>sumo3a</td><td>sumo3a-001</td><td>Small ubiquitin-related modifier 3-like</td><td>Cell cycle, division, growth and fate</td><td>PQ INCREASED</td><td>2.73</td><td>LMW</td></tr><tr><td>113</td><td>ENSDARP00000052555</td><td>sumo3b</td><td>sumo3b-001</td><td>Small ubiquitin-related modifier</td><td>Cell cycle, division, growth and fate</td><td>PQ INCREASED</td><td>2.73</td><td>LMW</td></tr><tr><td>114</td><td>ENSDARP00000108738</td><td>sumo3a</td><td>sumo3a-201</td><td>Small ubiquitin-related modifier 3-like</td><td>Cell cycle, division, growth and fate</td><td>PQ INCREASED</td><td>2.73</td><td>LMW</td></tr><tr><td>115</td><td>ENSDARP00000010242</td><td>sumo2b</td><td>sumo2b-201</td><td>Small ubiquitin-related modifier 2</td><td>Cell cycle, division, growth and fate</td><td>PQ INCREASED</td><td>2.71</td><td>LMW</td></tr></tbody></table>
<table>
  <tr>
    <td>116</td>
    <td>ENSDARP00000066628</td>
    <td>sumo2b</td>
    <td>sumo2b-001</td>
    <td>Small ubiquitin-related modifier 2</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.71</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>117</td>
    <td>ENSDARP00000066783</td>
    <td>cfl2</td>
    <td>cfl2-001</td>
    <td>Cofilin</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.69</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>118</td>
    <td>ENSDARP00000062369</td>
    <td>actc1a</td>
    <td>actc1a-001</td>
    <td>Actin, alpha, cardiac muscle 1a</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.54</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>119</td>
    <td>ENSDARP00000066429</td>
    <td>acta2</td>
    <td>acta2-201</td>
    <td>Actin, alpha 2, smooth muscle, aorta</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.54</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>120</td>
    <td>ENSDARP00000075110</td>
    <td>CH211-260D9.2-001</td>
    <td>Novel transcript</td>
    <td>Actin, novel</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.54</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>121</td>
    <td>ENSDARP00000100195</td>
    <td>ACTC1 (2 of 2)</td>
    <td>ACTC1 (2 of 2)-002</td>
    <td>Actin alpha 1 (ACTA1)-like</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.54</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>122</td>
    <td>ENSDARP00000100434</td>
    <td>si:ch73-187m15.4</td>
    <td>Novel transcript</td>
    <td>Actin, alpha, cardiac muscle 1a, novel</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.54</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>123</td>
    <td>ENSDARP0000009096</td>
    <td>rp12</td>
    <td>rp12-001</td>
    <td>Ribosomal protein L12</td>
    <td>Protein synthesis</td>
    <td>PQ INCREASED</td>
    <td>2.43</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>124</td>
    <td>ENSDARP00000124371</td>
    <td>acta2</td>
    <td>acta2-001</td>
    <td>Actin, alpha 2, smooth muscle, aorta</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.35</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>125</td>
    <td>ENSDARP00000069168</td>
    <td>nots</td>
    <td>nots-201</td>
    <td>Nothepsin</td>
    <td>Protein degradation and synthesis inhibition</td>
    <td>PQ INCREASED</td>
    <td>2.27</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>126</td>
    <td>ENSDARP00000119104</td>
    <td> dut</td>
    <td>dut-005</td>
    <td>dUTP pyrophosphatase</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.20</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>127</td>
    <td>ENSDARP00000122542</td>
    <td>ddx41</td>
    <td>ddx41-002</td>
    <td>DEAD (Asp-Glu-Ala-Asp) box polypeptide 41</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.03</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>128</td>
    <td>ENSDARP00000122730</td>
    <td>ddx41</td>
    <td>ddx41-001</td>
    <td>DEAD (Asp-Glu-Ala-Asp) box polypeptide 41</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.03</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>129</td>
    <td>ENSDARP00000118860</td>
    <td>si:ch1073-75o15.4</td>
    <td>si:ch1073-75o15.4-001</td>
    <td>SUEL type lectin domain</td>
    <td>Lectins</td>
    <td>PQ INCREASED</td>
    <td>1.94</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>130</td>
    <td>ENSDARP00000121416</td>
    <td>si:ch1073-75o15.4</td>
    <td>si:ch1073-75o15.4-002</td>
    <td>L-rhamnose-binding lectin CSL1-like isoform X1</td>
    <td>Lectins</td>
    <td>PQ INCREASED</td>
    <td>1.93</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>131</td>
    <td>ENSDARP00000120984</td>
    <td>si:ch211-145c1.1</td>
    <td>si:ch211-145c1.1-001</td>
    <td>Gal lectin superfamily, L-rhamnose-binding lectin CSL3</td>
    <td>Lectins</td>
    <td>PQ INCREASED</td>
    <td>6.88</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>132</td>
    <td>ENSDARP00000093515</td>
    <td>si:ch211-145c1.1</td>
    <td>si:ch211-145c1.1-002</td>
    <td>Gal lectin superfamily, L-rhamnose-binding lectin CSL3</td>
    <td>Lectins</td>
    <td>PQ INCREASED</td>
    <td>6.85</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>133</td>
    <td>ENSDARP00000020578</td>
    <td>cap1</td>
    <td>cap1-001</td>
    <td>Adenylate cyclase-associated protein</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>3.78</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>134</td>
    <td>ENSDARP0000005460</td>
    <td>c3b</td>
    <td>c3b-201</td>
    <td>Complement component c3b</td>
    <td>Immune system related</td>
    <td>PQ INCREASED</td>
    <td>3.13</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>135</td>
    <td>ENSDARP00000108724</td>
    <td>c3b</td>
    <td>c3b-001</td>
    <td>Complement component c3b</td>
    <td>Immune system related</td>
    <td>PQ INCREASED</td>
    <td>3.13</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>136</td>
    <td>ENSDARP00000076290</td>
    <td>pdia4</td>
    <td>pdia4-201</td>
    <td>Protein disulfide-isomerase A4</td>
    <td>Protein synthesis</td>
    <td>PQ INCREASED</td>
    <td>2.99</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>137</td>
    <td>ENSDARP00000027102</td>
    <td>nap1l1</td>
    <td>nap1l1-201</td>
    <td>Nucleosome assembly protein 1, like 1</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.76</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>138</td>
    <td>ENSDARP00000104033</td>
    <td>A2ML1 (7 of 12)</td>
    <td>A2ML1 (7 of 12)-201</td>
    <td>Alpha-2-macroglobulin-like 1</td>
    <td>Immune system related</td>
    <td>PQ INCREASED</td>
    <td>2.50</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>139</td>
    <td>ENSDARP00000121031</td>
    <td>hspa8</td>
    <td>hspa8-003</td>
    <td>Heat shock protein 8</td>
    <td>Protein synthesis</td>
    <td>PQ INCREASED</td>
    <td>2.47</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>140</td>
    <td>ENSDARP00000100695</td>
    <td>A2ML1 (7 of 12)</td>
    <td>A2ML1 (7 of 12)-001</td>
    <td>Alpha-2-macroglobulin-like 1</td>
    <td>Immune system related</td>
    <td>PQ INCREASED</td>
    <td>2.43</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>141</td>
    <td>ENSDARP00000100381</td>
    <td>A2ML1 (7 of 12)</td>
    <td>A2ML1 (7 of 12)-203</td>
    <td>Alpha-2-macroglobulin-like 1</td>
    <td>Immune system related</td>
    <td>PQ INCREASED</td>
    <td>2.38</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>142</td>
    <td>ENSDARP00000100196</td>
    <td>A2ML1 (7 of 12)</td>
    <td>A2ML1 (7 of 12)-202</td>
    <td>Alpha-2-macroglobulin-like 1</td>
    <td>Immune system related</td>
    <td>PQ INCREASED</td>
    <td>2.37</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>143</td>
    <td>ENSDARP00000124860</td>
    <td>nap1l4a</td>
    <td>nap1l4a-002</td>
    <td>Nucleosome assembly protein 1, like 1</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.25</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>144</td>
    <td>ENSDARP00000094479</td>
    <td>nap1l4a</td>
    <td>nap1l4a-001</td>
    <td>Nucleosome assembly protein 1, like 2</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.24</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>145</td>
    <td>ENSDARP00000100384</td>
    <td>prmt1</td>
    <td>prmt1-001</td>
    <td>Protein arginine methyltransferase 1</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>PQ INCREASED</td>
    <td>2.14</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>146</td>
    <td>ENSDARP00000027115</td>
    <td>tald01</td>
    <td>tald01-201</td>
    <td>Transaldolase</td>
    <td>Energy metabolism</td>
    <td>PQ INCREASED</td>
    <td>2.00</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>147</td>
    <td>ENSDARP00000067816</td>
    <td>chia3</td>
    <td>chia3-001</td>
    <td>Chitinase, acidic 3</td>
    <td>Immune system related</td>
    <td>PQ INCREASED</td>
    <td>2.00</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>148</td>
    <td>ENSDARP00000103361</td>
    <td>si:ch211-14a17.7</td>
    <td>si:ch211-14a17.7-201</td>
    <td>Zona pellucida protein superfamily</td>
    <td>Zona pellucida proteins</td>
    <td>PQ INCREASED</td>
    <td>2.00</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>149</td>
    <td>ENSDARP00000116459</td>
    <td>si:ch211-14a17.7</td>
    <td>si:ch211-14a17.7-001</td>
    <td>Zona pellucida protein superfamily</td>
    <td>Zona pellucida proteins</td>
    <td>PQ INCREASED</td>
    <td>2.00</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>150</td>
    <td>ENSDARP00000003107</td>
    <td>cct7</td>
    <td>cct7-001</td>
    <td>Chaperonin containing TCP1, subunit 7</td>
    <td>Protein synthesis</td>
    <td>PQ INCREASED</td>
    <td>2.00</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>151</td>
    <td>ENSDARP00000020361</td>
    <td>gcat</td>
    <td>gcat-001</td>
    <td>Glycine C-acetyltransferase</td>
    <td>Protein synthesis</td>
    <td>PQ INCREASED</td>
    <td>2.00</td>
    <td>HMW</td>
  </tr>
  <tr>
    <td>152</td>
    <td>ENSDARP00000090833</td>
    <td>prdx4</td>
    <td>prdx4-001</td>
    <td>Peroxiredoxin 4</td>
    <td>REDOX/Detox related</td>
    <td>GQ INCREASED</td>
    <td>0.50</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>153</td>
    <td>ENSDARP00000094194</td>
    <td>vtg3</td>
    <td>vtg3-202</td>
    <td>Vitellogenin 3</td>
    <td>Vitellogenin</td>
    <td>GQ INCREASED</td>
    <td>0.50</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>154</td>
    <td>ENSDARP00000072678</td>
    <td>vtg7</td>
    <td>vtg7-201</td>
    <td>Vitellogenin 7</td>
    <td>Vitellogenin</td>
    <td>GQ INCREASED</td>
    <td>0.50</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>155</td>
    <td>ENSDARP00000114558</td>
    <td>vtg7</td>
    <td>vtg7-001</td>
    <td>Vitellogenin 7</td>
    <td>Vitellogenin</td>
    <td>GQ INCREASED</td>
    <td>0.50</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>156</td>
    <td>ENSDARP00000116066</td>
    <td>celsr3</td>
    <td>celsr3-002</td>
    <td>Cadherin, EGF LAG seven-pass G-type receptor 3</td>
    <td>Other</td>
    <td>GQ INCREASED</td>
    <td>0.50</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>157</td>
    <td>ENSDARP00000118276</td>
    <td>si:dkey-90l23.1</td>
    <td>Novel transcript</td>
    <td>SUEL type lectin domain</td>
    <td>Lectins</td>
    <td>GQ INCREASED</td>
    <td>0.50</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>158</td>
    <td>ENSDARP00000063876</td>
    <td>prdx6</td>
    <td>prdx6-001</td>
    <td>Peroxiredoxin 6</td>
    <td>REDOX/Detox related</td>
    <td>GQ INCREASED</td>
    <td>0.50</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>159</td>
    <td>ENSDARP00000096079</td>
    <td>si:ch211-226h8.4</td>
    <td>si:ch211-226h8.4-001</td>
    <td>SUEL type lectin domain</td>
    <td>Lectins</td>
    <td>GQ INCREASED</td>
    <td>0.49</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>160</td>
    <td>ENSDARP00000115012</td>
    <td>vtg4</td>
    <td>vtg4-001</td>
    <td>Vitellogenin 4</td>
    <td>Vitellogenins</td>
    <td>GQ INCREASED</td>
    <td>0.49</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>161</td>
    <td>ENSDARP00000050237</td>
    <td>vtg1</td>
    <td>vtg1-001</td>
    <td>Vitellogenin 1</td>
    <td>Vitellogenins</td>
    <td>GQ INCREASED</td>
    <td>0.49</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>162</td>
    <td>ENSDARP00000101309</td>
    <td>vtg4</td>
    <td>vtg4-201</td>
    <td>Vitellogenin 4</td>
    <td>Vitellogenins</td>
    <td>GQ INCREASED</td>
    <td>0.49</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>163</td>
    <td>ENSDARP00000072738</td>
    <td>vtg1</td>
    <td>vtg1-201</td>
    <td>Vitellogenin 1</td>
    <td>Vitellogenins</td>
    <td>GQ INCREASED</td>
    <td>0.48</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>164</td>
    <td>ENSDARP00000072790</td>
    <td>vtg2</td>
    <td>vtg2-201</td>
    <td>Vitellogenin 2</td>
    <td>Vitellogenins</td>
    <td>GQ INCREASED</td>
    <td>0.47</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>165</td>
    <td>ENSDARP00000096034</td>
    <td>vtg2</td>
    <td>vtg2-202</td>
    <td>Vitellogenin 2</td>
    <td>Vitellogenins</td>
    <td>GQ INCREASED</td>
    <td>0.47</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>166</td>
    <td>ENSDARP00000120934</td>
    <td>prdx3</td>
    <td>prdx3-002</td>
    <td>Peroxiredoxin 3</td>
    <td>REDOX/Detox related</td>
    <td>GQ INCREASED</td>
    <td>0.45</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>167</td>
    <td>ENSDARP00000123406</td>
    <td>si:dkeyp-46h3.8</td>
    <td>si:dkeyp-46h3.8-001</td>
    <td>SUEL type lectin domain</td>
    <td>Lectins</td>
    <td>GQ INCREASED</td>
    <td>0.44</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>168</td>
    <td>ENSDARP00000115568</td>
    <td>si:dkeyp-46h3.8</td>
    <td>si:dkeyp-46h3.8-201</td>
    <td>SUEL type lectin domain</td>
    <td>Lectins</td>
    <td>GQ INCREASED</td>
    <td>0.44</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>169</td>
    <td>ENSDARP00000096443</td>
    <td>crp6</td>
    <td>crp6-001</td>
    <td>C-reactive protein 6</td>
    <td>Immune system related</td>
    <td>GQ INCREASED</td>
    <td>0.43</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>170</td>
    <td>ENSDARP00000113089</td>
    <td>dut</td>
    <td>dut-003</td>
    <td>dUTP pyrophosphatase</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.41</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>171</td>
    <td>ENSDARP00000122570</td>
    <td>dut</td>
    <td>dut-002</td>
    <td>dUTP pyrophosphatase</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.40</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>172</td>
    <td>ENSDARP000001068320</td>
    <td>dut</td>
    <td>dut-001</td>
    <td>dUTP pyrophosphatase-deoxyuridine triphosphatase</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.40</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>173</td>
    <td>ENSDARP00000023863</td>
    <td>me</td>
    <td>me-001</td>
    <td>Ribulose-5-phosphate-3-epimerase</td>
    <td>Energy metabolism</td>
    <td>GQ INCREASED</td>
    <td>0.40</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>174</td>
    <td>ENSDARP00000048374</td>
    <td>stmn4</td>
    <td>stmn4-001</td>
    <td>Stathmin-like 4</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.39</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>175</td>
    <td>ENSDARP00000113219</td>
    <td>stmn4</td>
    <td>stmn4-002</td>
    <td>Stathmin-like 4</td>
    <td>Cell cycle, division, growth and fate</td>
    <td>GQ INCREASED</td>
    <td>0.39</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>176</td>
    <td>ENSDARP00000023158</td>
    <td>vtg3</td>
    <td>vtg3-201</td>
    <td>Vitellogenin 3</td>
    <td>Vitellogenins</td>
    <td>GQ INCREASED</td>
    <td>0.38</td>
    <td>LMW</td>
  </tr>
  <tr>
    <td>177</td>
    <td>ENSDARP00000120407</td>
    <td>si:ch211-250e5.16</td>
    <td>si:ch211-250e5.16-001</td>
    <td>SUEL type lectin domain</td>
    <td>Lectins</td>
    <td>GQ INCREASED</td>
    <td>0.36</td>
    <td>LMW</td>
  </tr>
</table>
<table><tr><td>240</td><td>ENSDARP00000070667</td><td>zgc:171779</td><td>zgc:171779-201</td><td>Zona pellucida superfamily</td><td>Cell cycle, division, growth and fate</td><td>GQ INCREASED</td><td>0.24</td><td>HMW</td></tr><tr><td>241</td><td>ENSDARP0000006519</td><td>pgm1</td><td>pgm1-001</td><td>Phosphoglucomutase 1</td><td>Energy metabolism</td><td>GQ INCREASED</td><td>0.10</td><td>HMW</td></tr><tr><td>242</td><td>ENSDARP00000113349</td><td>KRT23 (1 of 2)</td><td>KRT23 (1 of 2)-003</td><td>Keratin 17</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>243</td><td>ENSDARP00000089806</td><td>si:ch211-251f6.7</td><td>si:ch211-251f6.7-201</td><td>Fish egg lectin like precursor</td><td>Lectins</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>244</td><td>ENSDARP00000113985</td><td>si:ch211-251f6.7</td><td>si:ch211-251f6.7-001</td><td>Fish egg lectin like precursor</td><td>Lectins</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>245</td><td>ENSDARP00000115840</td><td>dut</td><td>dut-004</td><td>Deoxyuridine triphosphatase</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>246</td><td>ENSDARP00000059013</td><td>zgc:173443</td><td>zgc:173443-001</td><td>Fish egg lectin like precursor</td><td>Lectins</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>247</td><td>ENSDARP00000034555</td><td>cycb</td><td>cycb-001</td><td>cytochrome c, sermatic b</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>248</td><td>ENSDARP00000037864</td><td>glrx</td><td>glrx-001</td><td>Glutaredoxin (thioltransferase)</td><td>Protein synthesis</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>249</td><td>ENSDARP00000076087</td><td>glrx</td><td>glrx-201</td><td>Glutaredoxin (thioltransferase)</td><td>Protein synthesis</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>250</td><td>ENSDARP00000120838</td><td>glrx</td><td>glrx-002</td><td>Glutaredoxin (thioltransferase)</td><td>Protein synthesis</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>251</td><td>ENSDARP00000121692</td><td>gstm3</td><td>gstm3-002</td><td>Glutathione S transferase M3 (brain)</td><td>REDOX/Detox related</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>252</td><td>ENSDARP00000051749</td><td>si:rp71-45k5.4</td><td>si:rp71-45k5.4-001</td><td>Proteasome subunit alpha 2</td><td>Protein degradation and synthesis inhibition</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>253</td><td>ENSDARP00000128459</td><td>si:rp71-45k5.4</td><td>si:rp71-45k5.4-202</td><td>Proteasome subunit alpha 2</td><td>Protein degradation and synthesis inhibition</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>254</td><td>ENSDARP00000058679</td><td>psma2</td><td>psma2-201</td><td>Proteasome subunit alpha 2</td><td>Protein degradation and synthesis inhibition</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>255</td><td>ENSDARP00000127697</td><td>si:rp71-45k5.4</td><td>si:rp71-45k5.4-201</td><td>Proteasome subunit alpha 2</td><td>Protein degradation and synthesis inhibition</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>256</td><td>ENSDARP00000075482</td><td>ab:cb252</td><td>ab:cb252-201</td><td>ES1 protein homolog, mitochondrial</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td><td>LMW</td></tr><tr><td>257</td><td>ENSDARP00000027268</td><td>gspt1l</td><td>gspt1l-001</td><td>G1 to S phase transition 1, like</td><td>Protein synthesis</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>258</td><td>ENSDARP00000039367</td><td>prmt1</td><td>prmt1-002</td><td>Protein arginine methyltransferase 1</td><td>Cell cycle, division, growth and fate</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>259</td><td>ENSDARP00000052324</td><td>f2</td><td>f2-001</td><td>Coagulation factor II, thrombin</td><td>Immune system related</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>260</td><td>ENSDARP00000057644</td><td>gsox1</td><td>gsox1-001</td><td>Quiescin Q6 sulfhydryl oxidase 1</td><td>Protein synthesis</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>261</td><td>ENSDARP00000096969</td><td>psmc5</td><td>psmc5-001</td><td>Proteasome (prosome, macropain) 26S subunit, ATPase, 5</td><td>Protein synthesis</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>262</td><td>ENSDARP00000104071</td><td>f2</td><td>f2-002</td><td>Coagulation factor II, thrombin</td><td>Immune system related</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>263</td><td>ENSDARP00000105266</td><td>zgc:152830</td><td>zgc:152830-201</td><td>Peptidase M17 superfamily</td><td>Protein degradation and synthesis inhibition</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>264</td><td>ENSDARP00000108730</td><td>tfa</td><td>tfa-202</td><td>Transferrin a</td><td>Immune system related</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>265</td><td>ENSDARP00000110443</td><td>BX323793.2</td><td>BX323793.2-201</td><td>1-phosphatidylinositol phosphodiesterase-like</td><td>Lipid metabolism</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>266</td><td>ENSDARP00000111409</td><td>si:dkey-152b24.7</td><td>si:dkey-152b24.7-201</td><td>1-phosphatidylinositol phosphodiesterase-like</td><td>Lipid metabolism</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>267</td><td>ENSDARP00000112306</td><td>pycr1b</td><td>pycr1b-201</td><td>Pyrroline-5-carboxylate reductase 1b</td><td>Protein degradation and synthesis inhibition</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>268</td><td>ENSDARP00000116484</td><td>gspt1l</td><td>gspt1l-002</td><td>G1 to S phase transition 1, like</td><td>Protein synthesis</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>269</td><td>ENSDARP00000116563</td><td>si:dkey-152b24.7</td><td>si:dkey-152b24.7-001</td><td>1-phosphatidylinositol phosphodiesterase-like</td><td>Lipid metabolism</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>270</td><td>ENSDARP00000117331</td><td>nasp</td><td>nasp-002</td><td>Nuclear autoantigenic sperm protein (histone-binding)</td><td>Protein synthesis</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>271</td><td>ENSDARP00000118947</td><td>gale</td><td>gale-002</td><td>UDP-galactose-4-epimerase</td><td>Energy metabolism</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>272</td><td>ENSDARP00000127771</td><td>zgc:152830</td><td>zgc:152830-001</td><td>Peptidase M17 superfamily</td><td>Protein degradation and synthesis inhibition</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>273</td><td>ENSDARP00000128522</td><td>tfa</td><td>tfa-003</td><td>Transferrin a</td><td>Immune system related</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr><tr><td>274</td><td>ENSDARP00000017776</td><td>A2ML1 (10 of 12)</td><td>A2ML1 (10 of 12)-201</td><td>Alpha-2-macroglobulin-like 1</td><td>Lipid metabolism</td><td>GQ UNIQUE</td><td>-</td><td>HMW</td></tr></table>
<table><caption>**S3 Table. Enrichment of PANTHER pathways with differentially regulated proteins.** Results of overrepresentation binomial tests [27] for enrichment of PANTHER pathways with proteins showing a ≥2-fold difference in N-SC between egg quality groups, or unique to an egg quality group, in the Pooled Samples Experiment (top) and in the Multiple Samples Experiment (bottom). Only statistically significant results (*p*<0.05 after Bonferroni correction for multiple tests) are reported. Numbers of mapped and unmapped proteins are given in **Fig 3** and **Fig 5**.</caption><thead><tr><th colspan="7">PANTHER Overrepresentation Test</th></tr><tr><td colspan="7">Analyzed List: Danio rerio (input - differentially regulated proteins)</td></tr><tr><th colspan="7">PANTHER version 11.0 Released 2016</th></tr><tr><td colspan="7">Reference List: Danio rerio (all genes in database)</td></tr><tr><th colspan="7">POOLED SAMPLES EXPERIMENT</th></tr><tr><th colspan="7">POOR QUALITY EGGS</th></tr><tr><th>PANTHER Pathways</th><th>REFLIST (27187)</th><th>Input (194)</th><th>Input (expected)</th><th>Input (over/under)</th><th>Input (fold Enrichment)</th><th>Input (P-value)</th></tr></thead><tbody><tr><td>Cytoskeletal regulation by Rho GTPase (P00016)</td><td>120</td><td>12</td><td>0.86</td><td>+</td><td>14.01</td><td>1.67E-08</td></tr><tr><td>Parkinson disease (P00049)</td><td>112</td><td>11</td><td>0.8</td><td>+</td><td>13.76</td><td>1.22E-07</td></tr><tr><td>Huntington disease (P00029)</td><td>183</td><td>13</td><td>1.31</td><td>+</td><td>9.96</td><td>1.69E-07</td></tr><tr><td>Cadherin signaling (P00012)</td><td>183</td><td>12</td><td>1.31</td><td>+</td><td>9.19</td><td>1.79E-06</td></tr><tr><td>FGF signaling (P00021)</td><td>160</td><td>10</td><td>1.14</td><td>+</td><td>8.76</td><td>4.69E-05</td></tr><tr><td>Nicotinic acetylcholine receptor signaling (P00044)</td><td>141</td><td>8</td><td>1.01</td><td>+</td><td>7.95</td><td>1.46E-03</td></tr><tr><td>EGF receptor signaling (P00018)</td><td>174</td><td>9</td><td>1.24</td><td>+</td><td>7.25</td><td>8.46E-04</td></tr><tr><td>Alzheimer disease-presenilin (P00004)</td><td>166</td><td>8</td><td>1.18</td><td>+</td><td>6.75</td><td>4.65E-03</td></tr><tr><td>Integrin signaling (P00034)</td><td>219</td><td>9</td><td>1.56</td><td>+</td><td>5.76</td><td>5.10E-03</td></tr><tr><td>Wnt signaling (P00057)</td><td>388</td><td>13</td><td>2.77</td><td>+</td><td>4.7</td><td>8.32E-04</td></tr><tr><td>Inflammation mediated by chemokine /cytokine signaling (P00031)</td><td>353</td><td>10</td><td>2.52</td><td>+</td><td>3.97</td><td>3.94E-02</td></tr><tr><td>Unclassified (UNCLASSIFIED)</td><td>24075</td><td>146</td><td>171.79</td><td>-</td><td>0.85</td><td>0.00E+00</td></tr><tr><th colspan="7">GOOD QUALITY EGGS</th></tr><tr><th>PANTHER Pathways</th><th>REFLIST (27187)</th><th>Input (251)</th><th>Input (expected)</th><th>Input (over/under)</th><th>Input (fold Enrichment)</th><th>Input (P-value)</th></tr><tr><td>Pyruvate metabolism (P02772)</td><td>15</td><td>6</td><td>0.14</td><td>+</td><td>43.33</td><td>1.26E-06</td></tr><tr><td>De novo purine biosynthesis (P02738)</td><td>33</td><td>4</td><td>0.3</td><td>+</td><td>13.13</td><td>4.22E-02</td></tr><tr><td>Unclassified (UNCLASSIFIED)</td><td>24075</td><td>188</td><td>222.27</td><td>-</td><td>0.85</td><td>0.00E+00</td></tr><tr><th colspan="7">MULTIPLE SAMPLES EXPERIMENT</th></tr><tr><th colspan="7">POOR QUALITY EGGS</th></tr><tr><th>PANTHER Pathways</th><th>REFLIST (27187)</th><th>Input (74)</th><th>Input (expected)</th><th>Input (over/under)</th><th>Input (fold Enrichment)</th><th>Input (P-value)</th></tr><tr><td>Cytoskeletal regulation by Rho GTPase (P00016)</td><td>120</td><td>15</td><td>0.33</td><td>+</td><td>45.92</td><td>1.03E-18</td></tr><tr><td>Huntington disease (P00029)</td><td>183</td><td>17</td><td>0.5</td><td>+</td><td>34.13</td><td>2.92E-19</td></tr><tr><td>Nicotinic acetylcholine receptor signaling pathway (P00044)</td><td>141</td><td>10</td><td>0.38</td><td>+</td><td>26.06</td><td>1.14E-09</td></tr><tr><td>Alzheimer disease-presenilin pathway (P00004)</td><td>166</td><td>11</td><td>0.45</td><td>+</td><td>24.35</td><td>1.98E-10</td></tr><tr><td>Cadherin signaling pathway (P00012)</td><td>183</td><td>11</td><td>0.5</td><td>+</td><td>22.08</td><td>5.57E-10</td></tr><tr><td>Parkinson disease (P00049)</td><td>112</td><td>6</td><td>0.3</td><td>+</td><td>19.68</td><td>1.09E-04</td></tr><tr><td>Integrin signaling pathway (P00034)</td><td>219</td><td>7</td><td>0.6</td><td>+</td><td>11.74</td><td>3.78E-04</td></tr><tr><td>Inflammation med. by chemokine &amp; cytokine signaling (P00031)</td><td>353</td><td>10</td><td>0.96</td><td>+</td><td>10.41</td><td>7.02E-06</td></tr><tr><td>Wnt signaling pathway (P00057)</td><td>388</td><td>9</td><td>1.06</td><td>+</td><td>8.52</td><td>1.80E-04</td></tr><tr><td>Unclassified (UNCLASSIFIED)</td><td>24075</td><td>43</td><td>65.53</td><td>-</td><td>0.66</td><td>0.00E+00</td></tr><tr><th colspan="7">GOOD QUALITY EGGS</th></tr><tr><th>PANTHER Pathways</th><th>REFLIST (27187)</th><th>Input (60)</th><th>Input (expected)</th><th>Input (over/under)</th><th>Input (fold Enrichment)</th><th>Input (P-value)</th></tr><tr><td>5-Hydroxytryptamine degradation (P04372)</td><td>19</td><td>3</td><td>0.04</td><td>+</td><td>71.54</td><td>1.73E-03</td></tr><tr><td>Unclassified (UNCLASSIFIED)</td><td>24075</td><td>43</td><td>53.13</td><td>-</td><td>0.81</td><td>0.00E+00</td></tr></tbody></table>
<figure><img src="image_10.png" /></figure>

<figure><img src="image_11.png" /><figcaption>S1 Fig. Enrichment of Molecular Function GO terms with differentially regulated proteins. Results of over-representation binomial tests [27] for enrichment of Molecular Function GO terms (PANTHER GO-Slim) with proteins up-regulated in good and poor quality zebrafish eggs. **Top Panel.** Pooled Samples Experiment. **Bottom Panel.** Multiple Samples Experiment. Horizontal bars indicate the number of proteins attributed to each GO term for which statistically significant results (*p*<0.05 after Bonferroni correction for multiple tests) were observed. Numbers next to the bars indicate the fold-enrichment with proteins attributed to each term and the number of asterisks indicates the significance level of the enrichment, as follows *p*<0.05 (*), *p*<0.01 (**), *p*<0.001 (***), and *p*<0.0001 (****).</figcaption></figure>
<figure><img src="image_12.png" /></figure>

<figure><img src="image_13.png" /><figcaption>S2 Fig. Enrichment of Protein Class GO terms with differentially regulated proteins. Results of over-representation binomial tests [27] for enrichment of Protein Class GO terms (PANTHER GO-Slim) with proteins up-regulated in good and poor quality zebrafish eggs. **Left Panel.** Pooled Samples Experiment. **Right Panel.** Multiple Samples Experiment. Horizontal bars indicate the number of proteins attributed to each GO term for which statistically significant results (*p*<0.05 after Bonferroni correction for multiple tests) were observed. Numbers next to the bars indicate the fold-enrichment with proteins attributed to each term and the number of asterisks indicates the significance level of the enrichment, as follows *p*<0.05 (*), *p*<0.01 (**), *p*<0.001 (****), and *p*<0.0001 (****).</figcaption></figure>
POOLED SAMPLES EXPERIMENT

GO-term

<figure><img src="image_14.png" /></figure>

MULTIPLE SAMPLES EXPERIMENT

GO-term

<figure><img src="image_15.png" /></figure>

S3 Fig. Enrichment of Cellular Component GO terms with differentially regulated proteins. Results of over-representation binomial tests [27] for enrichment of Cellular Component GO terms (PANTHER GO-Slim) with proteins up-regulated in good and poor quality zebrafish eggs. **Top Panel.** Pooled Samples Experiment. **Bottom Panel.** Multiple Samples Experiment. Horizontal bars indicate the number of proteins attributed to each GO term for which statistically significant results ($p \le 0.05$ after Bonferroni correction for multiple tests) were observed. Numbers next to the bars indicate the fold-enrichment with proteins attributed to each term and the number of asterisks indicates the significance level of the enrichment, as follows $p \le 0.05$ (*), $p \le 0.01$ (**), $p \le 0.001$ (***), and $p \le 0.0001$ (****).
**S4 Fig. Diagrams of PANTHER pathways enriched with differentially regulated proteins.** Proteins showing a ≥2-fold difference in N-SC between egg quality groups, or unique to an egg quality group, in the Pooled Samples Experiment and/or the Multiple Samples Experiment are mapped to the PANTHER pathways in which they were found to be overrepresented (see **S3 Table**). Pathways are presented as follows:

**Panel a.** Cytoskeletal regulation by Rho GTPase pathway (PANTHER pathway P00016)

**Panel b.** Parkinson disease pathway (PANTHER pathway P00049)

**Panel c.** Huntington's disease pathway (PANTHER pathway P00029)

**Panel d.** Cadherin signaling pathway (PANTHER pathway P00012)

**Panel e.** FGF signaling pathway (PANTHER pathway P00021)

**Panel f.** Nicotinic acetylcholine receptor signaling pathway (PANTHER pathway P00044)

**Panel g.** EGF receptor signaling pathway (PANTHER pathway P00018)

**Panel h.** Alzheimer's disease-presenilin pathway (PANTHER pathway P00004)

**Panel i.** Integrin signaling pathway (PANTHER pathway P00034)

**Panel j.** Wnt signaling pathway (PANTHER pathway P00057).

**Panel k.** Inflammation mediated by chemokine & cytokine signaling pathway (PANTHER pathway P00031)

**Panel l.** Pyruvate metabolism pathway (PANTHER pathway P02772)

**Panel m.** De novo purine biosynthesis (PANTHER pathway P02738)

**Panel n.** 5-Hydroxytryptamine degradation (PANTHER pathway P04372)
<figure><img src="image_16.png" /><figcaption>Cytoskeletal regulation by Rho GTPase pathway</figcaption></figure>

**Panel a.** Proteins up-regulated > 2-fold in poor quality zebrafish eggs, or unique to poor quality eggs, mapped to the Cytoskeletal regulation by Rho GTPase pathway (PANTHER pathway P00016) in which they were found to be overrepresented (see **S3 Table**). The zebrafish proteins are indicated by blue boxes with white text and are individually named in open boxes to the upper right with corresponding transcript names in parentheses. Dark blue boxes indicate mapped proteins from the Pooled Samples Experiment and light blue boxes indicate additional mapped proteins from the Multiple Samples Experiment. The mapped zebrafish proteins include actins (Actin*), actin-related protein 2/3 complex subunit 3 (ARP2/3*), tubulins (Tubulin*), and cofilin 1 protein-related protein.
<figure><img src="image_17.png" /><figcaption>Parkinson disease pathway</figcaption></figure>

**Panel b.** Proteins up-regulated ≥ 2-fold in poor quality zebrafish eggs, or unique to poor quality eggs, mapped to the Parkinson disease pathway (PANTHER pathway P00049) in which they were found to be overrepresented (see **S3 Table**). The zebrafish proteins are indicated by blue boxes with white text and are individually named in open boxes to the lower right with corresponding transcript names in parentheses. Dark blue boxes indicate mapped proteins from the Pooled Samples Experiment and light blue boxes indicate additional mapped proteins from the Multiple Samples Experiment. The mapped zebrafish proteins include 20S-proteasome components (20S proteasome*), variants of ubiquitin-conjugating enzyme E2L 3B (Ube213*), mitogen-activated kinase 1 (MAPK1*), variants of casein kinase II (Casein kinase II*), and 14-3-3 chaperone proteins (14-3-3*).
<figure><img src="image_18.png" /><figcaption>Huntington's disease pathway</figcaption></figure>

**Panel c.** Proteins up-regulated > 2-fold in poor quality zebrafish eggs, or unique to poor quality eggs, mapped to the Huntington's disease pathway (Panther pathway P00029) in which they were found to be overrepresented (see **S3 Table**). The zebrafish proteins are indicated by blue boxes with white text and are individually named in open boxes to the lower right with corresponding transcript names in parentheses. Dark blue boxes indicate mapped proteins from the Pooled Samples Experiment and light blue boxes indicate additional mapped proteins from the Multiple Samples Experiment. Aside from mitochondrial cytochrome c and variants of ADP-ribosylation factor 5, all of these zebrafish proteins are actins, tubulins or α-adaptin involved in clathrin-mediated endocytosis, a major activity in growing oocytes.
Cadherin signaling pathway

<figure><img src="image_19.png" /><figcaption>**Panel d.** Proteins upregulated > 2-fold in poor quality zebrafish eggs, or unique to poor quality eggs, mapped to the Cadherin signaling pathway (Panther pathway P00012) in which they were found to be overrepresented (see **S3 Table**). The zebrafish proteins are indicated by blue boxes with white text and are individually named in open boxes on the lower right with corresponding transcript names in parentheses. Dark blue boxes indicate mapped proteins from the Pooled Samples Experiment and light blue boxes indicate additional mapped proteins from the Multiple Samples Experiment. The mapped zebrafish proteins are all actins (Actin*), variants of casein kinase II (Casein kinase II*) or cadherin 1 (Cadherin*).</figcaption></figure>
<figure><img src="image_20.png" /><figcaption>FGF signaling pathway</figcaption></figure>

**Panel e.** Proteins up-regulated > 2-fold in poor quality zebrafish eggs, or unique to poor quality eggs, mapped to the FGF signaling pathway (Panther pathway P00021) in which they were found to be overrepresented (see **S3 Table**). The zebrafish proteins are indicated by blue boxes with white text and are individually named in open boxes on the lower left with corresponding transcript names in parentheses. The dark blue boxes indicate mapped proteins from the Pooled Samples Experiment. The mapped zebrafish proteins are all 14-3-3 chaperone proteins (14-3-3*), variants of serine/threonine protein phosphatase (PPP*), variants of dual specificity mitogen-activated protein kinase kinase 1 (MEK* and MAP2K*), or mitogen-activated protein kinase 1 (MAPK1*) and all were also mapped to the EGF signaling pathway (see **S4 Fig Panel g**).
Nicotinic acetylcholine receptor signaling pathway

<figure><img src="image_21.png" /></figure>

**Panel f.** Proteins up-regulated > 2-fold in poor quality zebrafish eggs, or unique to poor quality eggs, mapped to the Nicotinic acetylcholine receptor signaling pathway (Panther pathway P00044) in which they were found to be overrepresented (see **S3 Table**). The mapped zebrafish proteins from the Pooled Samples Experiment and the Multiple Samples Experiment are indicated by the blue box with white text and are individually named in open boxes on the right with corresponding transcript names in parentheses. Experiment. The mapped zebrafish proteins are all actins (Actin*).
<figure><img src="image_22.png" /><figcaption>EGF receptor signaling pathway</figcaption></figure>

**Panel g.** Proteins up-regulated > 2-fold in poor quality zebrafish eggs, or unique to poor quality eggs, mapped to the EGF receptor signaling pathway (Panther pathway P00018) in which they were found to be overrepresented (see **S3 Table**). The zebrafish proteins are indicated by the blue boxes with white text and are individually named in open boxes on the left with corresponding transcript names in parentheses. The dark blue boxes indicate mapped proteins from the Pooled Samples Experiment. The mapped zebrafish proteins are all 14-3-3 chaperone proteins (14-3-3*), variants of serine/threonine protein phosphatase (PPP*), variants of dual specificity mitogen-activated protein kinase kinase (MEK* and MAP2K*), or mitogen-activated protein kinase 1 (MAPK1*) and all were also mapped to the FGF signaling pathway (see **S4 Fig Panel e**).
<figure><img src="image_23.png" /><figcaption>Alzheimer's disease-presenilin pathway</figcaption></figure>

**Panel h.** Proteins up-regulated > 2-fold in poor quality zebrafish eggs, or unique to poor quality eggs, mapped to the Alzheimer's disease-presenilin pathway (Panther pathway P00004) in which they were found to be overrepresented (see **S3 Table**). The zebrafish proteins are indicated by blue boxes with white text and are individually named in open boxes on the upper right with corresponding transcript names in parentheses. Dark blue boxes indicate mapped proteins from the Pooled Samples Experiment and light blue shapes indicate mapped proteins from the Multiple Samples Experiment. The mapped zebrafish proteins are all actins (Actin*) or cadherin (Cadherin*).
<figure><img src="image_24.png" /><figcaption>Integrin signaling pathway</figcaption></figure>

cytoplasm

**Panel i.** Proteins up-regulated > 2-fold in poor quality zebrafish eggs, or unique to poor quality eggs, mapped to the Integrin signaling pathway (Panther pathway P00034) in which they were found to be overrepresented (see S3 Table).
The zebrafish proteins are indicated by blue boxes with white text and are individually named in open boxes in the center with corresponding transcript names in parentheses. Dark blue boxes indicate mapped proteins from the Pooled Samples Experiment and light blue boxes indicate additional mapped proteins from the Multiple Samples Experiment. The mapped zebrafish proteins are actins (Actin*), actin-related proteins (ARP2/3*), actinins (Actinin*), ADP-ribosylation factor-5 variants (ARF*), dual-specificity mitogen-activated protein kinases (MAP2K*), or mitogen-activated protein kinase 1 (MAPK1*).
<figure><img src="image_25.png" /><figcaption>**Panel j.** Proteins up-regulated > 2-fold in poor quality zebrafish eggs, or unique to poor quality eggs, mapped to the Wnt signaling pathway (Panther pathway P00057) in which they were found to be overrepresented (see **S3 Table**). The zebrafish proteins are indicated by the blue boxes with white text and are individually named in open boxes on the left with corresponding transcript names in parentheses. The dark blue boxes indicate mapped proteins from the Pooled Samples Experiment and the light blue boxes indicate mapped proteins from the Multiple Samples Experiment. The mapped zebrafish proteins are cadherin-1-related protein (Cadherin*), variants of casein kinase II (Casein kinase II*), actins (Actin*) or Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP*).</figcaption></figure>
Inflammation mediated by chemokine and cytokine signaling pathway

<figure><img src="image_26.png" /><figcaption>**Panel k.** Proteins up-regulated > 2-fold in poor quality zebrafish eggs, or unique to poor quality eggs, mapped to Inflammation mediated by chemokine and cytokine signaling pathway (Panther pathway P00031) in which they were found to be overrepresented (see **S3 Table**). The zebrafish proteins are indicated by blue boxes with white text and are individually named in open boxes at the lower left with corresponding transcript names in parentheses. Dark blue boxes indicate mapped proteins from the Pooled Samples Experiment and the Multiple Samples Experiment. The mapped zebrafish proteins are actins (Actin*), actin-related protein 2/3 complex subunit 3 (Arp2/3*) and mitogen-activated protein kinase (MAPK*)</figcaption></figure>
<figure><img src="image_27.png" /><figcaption>Pyruvate metabolism pathway</figcaption></figure>

**Panel I.** Proteins up-regulated > 2-fold in good quality zebrafish eggs, or unique to good quality eggs, in the Pooled Samples Experiment mapped to the Pyruvate metabolism pathway (Panther pathway P02772) in which they were found to be overrepresented (see **S3 Table**). The zebrafish proteins are indicated by the dark blue boxes with white text and are individually named in open boxes on the lower right with corresponding transcript names in parentheses. The mapped zebrafish proteins are pyruvate kinase (Pyruvate kinase*), Pyruvate carboxylase (Pyruvate carboxylase*), malic enzyme fragments (Malic enzyme*) and citrate lyase subunit beta-like protein (Citrate lyase).
De novo purine biosynthesis

<figure><img src="image_28.png" /></figure>

**Panel m.** Proteins upregulated > 2-fold in good quality zebrafish eggs, or unique to good quality eggs, in the Pooled Samples Experiment mapped to De novo purine biosynthesis (Panther pathway P02738) in which they were found to be overrepresented (see **S3 Table**). The zebrafish proteins are indicated by the dark blue boxes with white text and are individually named in open boxes in the lower center with corresponding transcript names in parentheses. The mapped zebrafish proteins are adenylosuccinate lyase (ADSL*) and various forms of Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase*)
<figure><img src="image_29.png" /><figcaption>5-Hydroxytryptamine degradation</figcaption></figure>

Aldehyde dehydrogenase* includes:

Aldehyde dehydrogenase 2.1 (aldh2.1)

Aldehyde dehydrogenase 2.2 (aldh2.2)

Aldehyde dehydrogenase 2-like (aldh2l)

**Panel n.** Proteins up-regulated > 2-fold in good quality zebrafish eggs, or unique to good quality eggs, in the Pooled Samples Experiment or the Multiple Samples Experiment mapped to 5-Hydroxytryptamine degradation (Panther pathway P04372) in which they were found to be overrepresented (see **S3 Table**). The zebrafish proteins are indicated by the blue box with white text and are individually named in open boxes on the lower right with corresponding transcript names in parentheses. The mapped zebrafish proteins are all variants of aldehyde dehydrogenase (Aldehyde dehydrogenase*).