# The impact of pediatric concussion on cerebellum neurodevelopment

Valentine Chouquet, Fanny Dégeilh

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Valentine Chouquet, Fanny Dégeilh. The impact of pediatric concussion on cerebellum neurodevelopment. 2025 - 15th World Congress on Brain Injury, Mar 2025, Montréal (Québec), Canada. pp.1-1, 2025. [hal-05017742](https://hal.science/hal-05017742v1)

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Submitted on 2 Apr 2025

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Distributed under a Creative Commons Attribution 4.0 International License
# The impact of pediatric concussion on cerebellum neurodevelopment

Valentine CHOUQUET¹, Fanny DÉGEILH¹

1.Univ Rennes, Inria, CNRS, Inserm, IRISA UMR 6074, Empenn ERL 1228, F-35042 Rennes, France

## 1. Introduction

**Cerebellum** develops through **childhood/adolescence**

In 150 children (8-18y) with concussion: **altered interhemispheric connectivity** (right supplementary motor area ↔ left cerebellum) = “cortico-cerebellar uncoupling”¹

Limited knowledge on cerebellar structural development post-pediatric
concussion

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Cerebellum

Grey Matter (GM)

White Matter (WM)

The Aim of the study : To characterize cerebellum structural development
in young adolescents with childhood concussion (ABCD Study)²

## 3. Results

<figure><img src="image_4.png" /><figcaption>Fig.2 - Distribution of Left Cerebellar White Matter Volume by Sex Over Time</figcaption></figure>

<figure><img src="image_5.png" /><figcaption>Fig.3 - Distribution of Left Cerebellar Grey Matter Volume by Parental Education Level Over Time</figcaption></figure>

<figure><img src="image_6.png" /></figure>

These graphs were created by selecting, among 4 metrics, the one that provided the best visual representation, with no impact on the results.

## References

1. (van der Horn et al., 2024); 2.(Casey et al., 2018); 3.(Garavan et al., 2018); 4.(Bogner et al., 2017);

5. (Beer et al., 2020); 6.(Mirman, 2017)

## 2. Methods

The following **baseline, 2 years** and **4 years follow-up** data from
the ABCD 5.1³ curated data release were used:

<table><tr><td>1</td><td><strong>The Parent Ohio State TBI Screen-Short Modified Report<sup>4</sup></strong><br><strong>Children without concussion</strong> (n = <strong>9,428</strong>; baseline mean age<br>= 9.9 years; 4,721 ♀ [50.6%])<br><strong>Children with a concussion</strong> (i.e., head-neck injury with loss of<br>consciousness ≤ 30 min or memory loss; n = <strong>319</strong>;<br>baseline mean age = 9.9 years; 133 ♀ [41.7%])</td></tr><tr><td>2</td><td><strong>T1-weighted images</strong></td></tr><tr><td>3</td><td><strong>Right and Left cerebellum GM and WM volumes computed on<br>T1-weighted images by the ABCD group</strong></td></tr><tr><td>3</td><td><strong>Longitudinal-ComBat</strong></td></tr><tr><td>4</td><td><strong>Scanner effects were controlled for using longitudinal-ComBat<sup>5</sup></strong></td></tr><tr><td>4</td><td><strong>Mixed effects models<sup>6</sup></strong><br>Constructed with <em>ImerTest_3.1.3</em> in <em>R(2023.12.1)</em> to assess group<br>differences at baseline and on the rate of change between<br>ages 10 to 14 years<br>Sex and parental education were included as covariates</td></tr></table>

## 4. Discussion

<figure><img src="image_7.png" /></figure>

No group effect on the developmental trajectories of the 4 cerebellar volumes (Fig.1)

<figure><img src="image_8.png" /></figure>

Significant effect of sex and education on both intercept and slope for
the 4 metrics (all *p* < 0.02) :

<figure><img src="image_9.png" /></figure>

Girls showed lower WM and GM volumes than boys at baseline and slower increase over time (all *p* < 2e-16) (Fig.2)

<figure><img src="image_10.png" /></figure>

Higher level of parental education was associated with larger WM and GM volumes at baseline (all *p* < 2e-16) and faster increase over time (Fig.3)

## 5. Conclusion

* **Cerebellum development (ages 10-14):** similar trajectory in adolescents with/without concussion

* **Factors influencing development:** sex, parental education

* **Further research:**

* Group*sex interaction

* Brain connectivity (diffusion MRI)

* Full understanding of findings

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50
1973
2023
IRISA

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Université
de Rennes

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cnrs

Inserm
Institut national
de la santé et de la recherche médicale

<figure><img src="image_16.png" /></figure>