<table>
  <tr>
    <td>rs17255241</td>
    <td>rs2164950</td>
    <td>1.36E-11</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>6.00E-03</td>
    <td>5.04E-02</td>
  </tr>
  <tr>
    <td>rs17255395</td>
    <td>rs2164950</td>
    <td>5.38E-27</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>6.00E-03</td>
    <td>2.01E-05</td>
  </tr>
  <tr>
    <td>rs75255901</td>
    <td>rs2164950</td>
    <td>7.67E-27</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>6.00E-03</td>
    <td>1.70E-05</td>
  </tr>
  <tr>
    <td>rs75666025</td>
    <td>rs2164950</td>
    <td>7.32E-12</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>6.00E-03</td>
    <td>5.37E-02</td>
  </tr>
  <tr>
    <td>rs78032956</td>
    <td>rs2164950</td>
    <td>8.86E-27</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>6.00E-03</td>
    <td>1.87E-06</td>
  </tr>
  <tr>
    <td>rs78349529</td>
    <td>rs2164950</td>
    <td>3.63E-25</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>6.00E-03</td>
    <td>7.50E-07</td>
  </tr>
  <tr>
    <td>rs79676525</td>
    <td>rs2164950</td>
    <td>1.67E-26</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>6.00E-03</td>
    <td>1.96E-06</td>
  </tr>
  <tr>
    <td>rs4901902</td>
    <td>rs2164950</td>
    <td>5.79E-28</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.50E-03</td>
    <td>4.12E-07</td>
  </tr>
  <tr>
    <td>rs75923883</td>
    <td>rs2164950</td>
    <td>3.30E-12</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.50E-03</td>
    <td>8.29E-02</td>
  </tr>
  <tr>
    <td>rs78090044</td>
    <td>rs2164950</td>
    <td>4.26E-12</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.50E-03</td>
    <td>8.29E-02</td>
  </tr>
  <tr>
    <td>rs78091436</td>
    <td>rs2164950</td>
    <td>1.28E-11</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.50E-03</td>
    <td>5.46E-02</td>
  </tr>
  <tr>
    <td>rs79360654</td>
    <td>rs2164950</td>
    <td>1.30E-24</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.50E-03</td>
    <td>1.49E-06</td>
  </tr>
  <tr>
    <td>rs17255220</td>
    <td>rs2164950</td>
    <td>1.29E-11</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.00E-03</td>
    <td>5.40E-02</td>
  </tr>
  <tr>
    <td>rs17255248</td>
    <td>rs2164950</td>
    <td>3.39E-12</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.00E-03</td>
    <td>8.29E-02</td>
  </tr>
  <tr>
    <td>rs17833632</td>
    <td>rs2164950</td>
    <td>1.45E-11</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.00E-03</td>
    <td>4.95E-02</td>
  </tr>
  <tr>
    <td>rs74749999</td>
    <td>rs2164950</td>
    <td>1.55E-11</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.00E-03</td>
    <td>3.66E-02</td>
  </tr>
  <tr>
    <td>rs75468739</td>
    <td>rs2164950</td>
    <td>1.69E-11</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.00E-03</td>
    <td>3.66E-02</td>
  </tr>
  <tr>
    <td>rs75514756</td>
    <td>rs2164950</td>
    <td>3.01E-12</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.00E-03</td>
    <td>8.29E-02</td>
  </tr>
  <tr>
    <td>rs77542809</td>
    <td>rs2164950</td>
    <td>1.76E-11</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.00E-03</td>
    <td>3.64E-02</td>
  </tr>
  <tr>
    <td>rs77618329</td>
    <td>rs2164950</td>
    <td>1.32E-24</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>5.00E-03</td>
    <td>1.46E-06</td>
  </tr>
  <tr>
    <td>rs17833614</td>
    <td>rs2164950</td>
    <td>1.34E-11</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>4.50E-03</td>
    <td>3.66E-02</td>
  </tr>
  <tr>
    <td>rs72726305</td>
    <td>rs2164950</td>
    <td>1.29E-20</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>4.50E-03</td>
    <td>1.99E-04</td>
  </tr>
  <tr>
    <td>rs117513981</td>
    <td>rs2164950</td>
    <td>3.29E-12</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>4.00E-03</td>
    <td>8.29E-02</td>
  </tr>
  <tr>
    <td>rs76850797</td>
    <td>rs2164950</td>
    <td>2.67E-25</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>4.00E-03</td>
    <td>8.00E-07</td>
  </tr>
  <tr>
    <td>14:59631075_GTTGT_G</td>
    <td>rs2164950</td>
    <td>2.69E-06</td>
    <td>DAAM1</td>
    <td>T-cell_CD4 (Kasela_2017)</td>
    <td>3.50E-03</td>
    <td>4.62E-07</td>
  </tr>
  <tr>
    <td>rs10498489</td>
    <td>rs2164950</td>
    <td>6.31E-27</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>3.50E-03</td>
    <td>1.96E-06</td>
  </tr>
  <tr>
    <td>rs17255332</td>
    <td>rs2164950</td>
    <td>2.38E-26</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>3.50E-03</td>
    <td>1.73E-06</td>
  </tr>
  <tr>
    <td>rs75012551</td>
    <td>rs2164950</td>
    <td>4.50E-12</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>3.50E-03</td>
    <td>8.29E-02</td>
  </tr>
  <tr>
    <td>rs75951218</td>
    <td>rs2164950</td>
    <td>1.99E-11</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>3.50E-03</td>
    <td>4.66E-02</td>
  </tr>
  <tr>
    <td>rs78035000</td>
    <td>rs2164950</td>
    <td>3.89E-12</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>3.50E-03</td>
    <td>8.29E-02</td>
  </tr>
  <tr>
    <td>rs78339200</td>
    <td>rs2164950</td>
    <td>3.22E-12</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>3.50E-03</td>
    <td>8.29E-02</td>
  </tr>
  <tr>
    <td>rs72724695</td>
    <td>rs2164950</td>
    <td>8.14E-21</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>3.00E-03</td>
    <td>1.47E-04</td>
  </tr>
  <tr>
    <td>rs10498487</td>
    <td>rs2164950</td>
    <td>9.45E-21</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>2.50E-03</td>
    <td>1.97E-04</td>
  </tr>
  <tr>
    <td>rs117804823</td>
    <td>rs2164950</td>
    <td>3.73E-12</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>2.50E-03</td>
    <td>8.29E-02</td>
  </tr>
  <tr>
    <td>rs78580207</td>
    <td>rs2164950</td>
    <td>6.49E-27</td>
    <td>DAAM1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>2.00E-03</td>
    <td>1.98E-06</td>
  </tr>
  <tr>
    <td>rs61784835</td>
    <td>rs6658111</td>
    <td>1.05E-12</td>
    <td>CMPK1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>8.59E-01</td>
    <td>6.04E-04</td>
  </tr>
  <tr>
    <td>rs6658111</td>
    <td>rs6658111</td>
    <td>3.34E-12</td>
    <td>CMPK1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>1.64E-01</td>
    <td>3.21E-03</td>
  </tr>
  <tr>
    <td>rs72688340</td>
    <td>rs6658111</td>
    <td>4.91E-08</td>
    <td>CMPK1</td>
    <td>blood (eQTLGen_cis)</td>
    <td>1.55E-02</td>
    <td>1.62E-02</td>
  </tr>
</table>
<table><caption>**Table A6.** *eQTLs identified by FUMA for IHI in the right hemisphere.* The variant rsID is shown alongside the topvariant of the locus, the probability of the eQTL (p), the symbol of the regulated gene, the PIP of the variant and the probability of the variant in the replication GWAS (p replication)</caption><thead><tr><th>variant</th><th>Topvariant</th><th>p</th><th>symbol</th><th>tissue</th><th>PIP</th><th>p replication</th></tr></thead><tbody><tr><td>rs11636628</td><td>rs11636628</td><td>2.30E-09</td><td>VIMP</td><td>blood (eQTLGen_cis)</td><td>7.50E-03</td><td>1.09E-03</td></tr><tr><td>rs2192476</td><td>rs11767221</td><td>1.15E-04</td><td>TWISTNB</td><td>Thyroid</td><td>1.75E-02</td><td>5.16E-03</td></tr><tr><td>rs11767221</td><td>rs11767221</td><td>1.60E-04</td><td>TWISTNB</td><td>Thyroid</td><td>1.20E-02</td><td>1.78E-02</td></tr><tr><td>rs4236295</td><td>rs11767221</td><td>1.64E-04</td><td>TWISTNB</td><td>Thyroid</td><td>9.50E-03</td><td>8.10E-03</td></tr><tr><td>rs10267686</td><td>rs11767221</td><td>1.20E-04</td><td>TWISTNB</td><td>Thyroid</td><td>8.50E-03</td><td>1.41E-02</td></tr><tr><td>rs4719574</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>6.27E-01</td><td>3.35E-03</td></tr><tr><td>rs9655175</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.85E-01</td><td>3.49E-03</td></tr><tr><td>rs9655174</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>7.15E-02</td><td>3.55E-03</td></tr><tr><td>rs7798205</td><td>rs11767221</td><td>5.95E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>3.75E-02</td><td>4.44E-03</td></tr><tr><td>rs2192476</td><td>rs11767221</td><td>4.52E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.75E-02</td><td>5.16E-03</td></tr><tr><td>rs4719576</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.65E-02</td><td>3.55E-03</td></tr><tr><td>rs4721791</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.60E-02</td><td>3.47E-03</td></tr><tr><td>rs10252608</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.40E-02</td><td>3.25E-03</td></tr><tr><td>rs10278898</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.25E-02</td><td>3.25E-03</td></tr><tr><td>rs11767221</td><td>rs11767221</td><td>2.48E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.20E-02</td><td>1.78E-02</td></tr><tr><td>rs7779144</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.20E-02</td><td>3.47E-03</td></tr><tr><td>rs7802880</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.20E-02</td><td>4.86E-03</td></tr><tr><td>rs2390146</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.15E-02</td><td>4.55E-03</td></tr><tr><td>rs7796085</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.15E-02</td><td>4.24E-03</td></tr><tr><td>rs10241336</td><td>rs11767221</td><td>5.27E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.05E-02</td><td>1.74E-02</td></tr><tr><td>rs4141046</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>1.05E-02</td><td>3.25E-03</td></tr><tr><td>rs2109876</td><td>rs11767221</td><td>4.22E-25</td><td>TWIST1</td><td>Nerve_Tibial</td><td>9.50E-03</td><td>3.25E-03</td></tr><tr><td>rs4236295</td><td>rs11767221</td><td>7.43E-22</td><td>TWIST1</td><td>Nerve_Tibial</td><td>9.50E-03</td><td>8.10E-03</td></tr><tr><td>rs7801835</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>9.50E-03</td><td>3.55E-03</td></tr><tr><td>rs10278656</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>9.00E-03</td><td>3.98E-03</td></tr><tr><td>rs17451868</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>9.00E-03</td><td>3.25E-03</td></tr><tr><td>rs2390143</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>9.00E-03</td><td>4.72E-03</td></tr><tr><td>rs4719575</td><td>rs11767221</td><td>8.46E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>9.00E-03</td><td>3.49E-03</td></tr><tr><td>rs10230207</td><td>rs11767221</td><td>1.30E-23</td><td>TWIST1</td><td>Nerve_Tibial</td><td>8.50E-03</td><td>4.21E-03</td></tr><tr><td>rs10249487</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>8.50E-03</td><td>4.01E-03</td></tr><tr><td>rs10267686</td><td>rs11767221</td><td>1.72E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>8.50E-03</td><td>1.41E-02</td></tr><tr><td>rs10807794</td><td>rs11767221</td><td>3.22E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>8.50E-03</td><td>4.99E-03</td></tr><tr><td>rs1121732</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>8.50E-03</td><td>3.22E-03</td></tr><tr><td>rs12668384</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>8.50E-03</td><td>3.65E-03</td></tr><tr><td>rs2390142</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>8.50E-03</td><td>4.72E-03</td></tr><tr><td>rs28808719</td><td>rs11767221</td><td>5.48E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>8.50E-03</td><td>3.25E-03</td></tr></tbody></table>
<table>
  <tr>
    <td>rs4721801</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>8.50E-03</td>
    <td>3.39E-03</td>
  </tr>
  <tr>
    <td>rs7800139</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>8.50E-03</td>
    <td>3.18E-03</td>
  </tr>
  <tr>
    <td>7:19604891_CT_C</td>
    <td>rs11767221</td>
    <td>4.33E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>8.00E-03</td>
    <td>1.43E-02</td>
  </tr>
  <tr>
    <td>rs2390145</td>
    <td>rs11767221</td>
    <td>4.91E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>8.00E-03</td>
    <td>4.72E-03</td>
  </tr>
  <tr>
    <td>rs7785223</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>8.00E-03</td>
    <td>3.49E-03</td>
  </tr>
  <tr>
    <td>rs7796222</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>8.00E-03</td>
    <td>3.72E-03</td>
  </tr>
  <tr>
    <td>rs9986862</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>8.00E-03</td>
    <td>3.25E-03</td>
  </tr>
  <tr>
    <td>rs10229434</td>
    <td>rs11767221</td>
    <td>1.46E-21</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>7.50E-03</td>
    <td>3.81E-02</td>
  </tr>
  <tr>
    <td>rs10249288</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>7.50E-03</td>
    <td>4.06E-03</td>
  </tr>
  <tr>
    <td>rs10273311</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>7.50E-03</td>
    <td>3.25E-03</td>
  </tr>
  <tr>
    <td>rs1074858</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>7.50E-03</td>
    <td>3.53E-03</td>
  </tr>
  <tr>
    <td>rs1121730</td>
    <td>rs11767221</td>
    <td>6.04E-25</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>7.50E-03</td>
    <td>3.25E-03</td>
  </tr>
  <tr>
    <td>rs1121731</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>7.50E-03</td>
    <td>3.22E-03</td>
  </tr>
  <tr>
    <td>rs3944043</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>7.50E-03</td>
    <td>3.19E-03</td>
  </tr>
  <tr>
    <td>rs4504538</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>7.50E-03</td>
    <td>3.21E-03</td>
  </tr>
  <tr>
    <td>rs714392</td>
    <td>rs11767221</td>
    <td>5.19E-21</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>7.00E-03</td>
    <td>9.21E-03</td>
  </tr>
  <tr>
    <td>rs7800812</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>7.00E-03</td>
    <td>3.30E-03</td>
  </tr>
  <tr>
    <td>rs12668367</td>
    <td>rs11767221</td>
    <td>4.91E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>6.50E-03</td>
    <td>3.48E-03</td>
  </tr>
  <tr>
    <td>rs13438043</td>
    <td>rs11767221</td>
    <td>4.91E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>6.50E-03</td>
    <td>4.72E-03</td>
  </tr>
  <tr>
    <td>rs2109875</td>
    <td>rs11767221</td>
    <td>9.11E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>6.50E-03</td>
    <td>3.25E-03</td>
  </tr>
  <tr>
    <td>rs6461446</td>
    <td>rs11767221</td>
    <td>3.45E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>6.50E-03</td>
    <td>4.37E-03</td>
  </tr>
  <tr>
    <td>rs13437937</td>
    <td>rs11767221</td>
    <td>4.91E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>6.00E-03</td>
    <td>3.61E-03</td>
  </tr>
  <tr>
    <td>rs4560698</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>6.00E-03</td>
    <td>3.15E-03</td>
  </tr>
  <tr>
    <td>rs4721798</td>
    <td>rs11767221</td>
    <td>6.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>6.00E-03</td>
    <td>3.00E-03</td>
  </tr>
  <tr>
    <td>rs7456896</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>6.00E-03</td>
    <td>3.39E-03</td>
  </tr>
  <tr>
    <td>rs7782309</td>
    <td>rs11767221</td>
    <td>4.91E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>6.00E-03</td>
    <td>3.48E-03</td>
  </tr>
  <tr>
    <td>rs12538102</td>
    <td>rs11767221</td>
    <td>1.16E-25</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>5.50E-03</td>
    <td>4.01E-03</td>
  </tr>
  <tr>
    <td>rs2058423</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>5.50E-03</td>
    <td>3.36E-03</td>
  </tr>
  <tr>
    <td>rs2215634</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>5.50E-03</td>
    <td>3.51E-03</td>
  </tr>
  <tr>
    <td>rs2390144</td>
    <td>rs11767221</td>
    <td>4.91E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>5.50E-03</td>
    <td>4.72E-03</td>
  </tr>
  <tr>
    <td>rs4721792</td>
    <td>rs11767221</td>
    <td>4.91E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>5.50E-03</td>
    <td>3.55E-03</td>
  </tr>
  <tr>
    <td>rs4721794</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>5.50E-03</td>
    <td>3.53E-03</td>
  </tr>
  <tr>
    <td>rs9986695</td>
    <td>rs11767221</td>
    <td>7.83E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>5.50E-03</td>
    <td>3.19E-03</td>
  </tr>
  <tr>
    <td>rs2109872</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>5.00E-03</td>
    <td>3.21E-03</td>
  </tr>
  <tr>
    <td>rs4141045</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>5.00E-03</td>
    <td>3.25E-03</td>
  </tr>
  <tr>
    <td>rs7785608</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>5.00E-03</td>
    <td>3.13E-03</td>
  </tr>
  <tr>
    <td>rs12666412</td>
    <td>rs11767221</td>
    <td>7.83E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>4.50E-03</td>
    <td>3.19E-03</td>
  </tr>
  <tr>
    <td>rs2058422</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>4.50E-03</td>
    <td>3.30E-03</td>
  </tr>
  <tr>
    <td>rs4333484</td>
    <td>rs11767221</td>
    <td>5.87E-26</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>4.50E-03</td>
    <td>3.18E-03</td>
  </tr>
  <tr>
    <td>rs10228147</td>
    <td>rs11767221</td>
    <td>1.87E-25</td>
    <td>TWIST1</td>
    <td>Nerve_Tibial</td>
    <td>4.00E-03</td>
    <td>3.25E-03</td>
  </tr>
</table>
<table><tr><td>rs1121733</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>4.00E-03</td><td>3.17E-03</td></tr><tr><td>rs13438100</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>4.00E-03</td><td>4.72E-03</td></tr><tr><td>rs2109877</td><td>rs11767221</td><td>7.83E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>4.00E-03</td><td>3.19E-03</td></tr><tr><td>rs28813981</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>4.00E-03</td><td>2.50E-03</td></tr><tr><td>rs2109874</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>3.50E-03</td><td>3.21E-03</td></tr><tr><td>rs4626493</td><td>rs11767221</td><td>4.91E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>3.50E-03</td><td>4.72E-03</td></tr><tr><td>rs2109873</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>3.00E-03</td><td>3.21E-03</td></tr><tr><td>rs4721797</td><td>rs11767221</td><td>6.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>3.00E-03</td><td>3.00E-03</td></tr><tr><td>rs1121734</td><td>rs11767221</td><td>5.87E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>2.50E-03</td><td>2.55E-03</td></tr><tr><td>rs6461445</td><td>rs11767221</td><td>3.45E-26</td><td>TWIST1</td><td>Nerve_Tibial</td><td>2.50E-03</td><td>4.44E-03</td></tr><tr><td>rs6774654</td><td>rs34620562</td><td>2.35E-04</td><td>TIPARP</td><td>Adipose_Subcutaneous</td><td>1.31E-01</td><td>9.99E-02</td></tr><tr><td>rs1351654</td><td>rs34620562</td><td>1.74E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>1.09E-01</td><td>1.39E-02</td></tr><tr><td>rs4680334</td><td>rs34620562</td><td>1.74E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>8.00E-02</td><td>1.39E-02</td></tr><tr><td>rs4680333</td><td>rs34620562</td><td>1.74E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>6.70E-02</td><td>1.48E-02</td></tr><tr><td>rs1482863</td><td>rs34620562</td><td>1.05E-04</td><td>TIPARP</td><td>Nerve_Tibial</td><td>5.95E-02</td><td>1.22E-02</td></tr><tr><td>rs1552194</td><td>rs34620562</td><td>7.09E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>5.05E-02</td><td>1.56E-02</td></tr><tr><td>rs6441108</td><td>rs34620562</td><td>1.74E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>3.25E-02</td><td>1.48E-02</td></tr><tr><td>rs9860977</td><td>rs34620562</td><td>2.32E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>3.20E-02</td><td>1.05E-02</td></tr><tr><td>rs9818500</td><td>rs34620562</td><td>1.76E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>2.65E-02</td><td>9.72E-03</td></tr><tr><td>rs1482856</td><td>rs34620562</td><td>1.76E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>2.15E-02</td><td>9.72E-03</td></tr><tr><td>rs9880927</td><td>rs34620562</td><td>9.71E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>2.15E-02</td><td>1.35E-02</td></tr><tr><td>rs6797982</td><td>rs34620562</td><td>8.27E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>2.00E-02</td><td>4.78E-03</td></tr><tr><td>rs10936057</td><td>rs34620562</td><td>1.74E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>1.95E-02</td><td>1.41E-02</td></tr><tr><td>rs6774012</td><td>rs34620562</td><td>7.09E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>1.95E-02</td><td>1.69E-02</td></tr><tr><td>rs922865</td><td>rs34620562</td><td>1.58E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>1.95E-02</td><td>1.05E-02</td></tr><tr><td>rs9838466</td><td>rs34620562</td><td>1.74E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>1.90E-02</td><td>1.48E-02</td></tr><tr><td>rs931245</td><td>rs34620562</td><td>9.54E-05</td><td>TIPARP</td><td>Adipose_Subcutaneous</td><td>1.70E-02</td><td>7.02E-02</td></tr><tr><td>rs9842862</td><td>rs34620562</td><td>8.44E-05</td><td>TIPARP</td><td>Adipose_Subcutaneous</td><td>1.65E-02</td><td>7.55E-03</td></tr><tr><td>rs2321459</td><td>rs34620562</td><td>1.74E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>1.60E-02</td><td>1.39E-02</td></tr><tr><td>rs6779199</td><td>rs34620562</td><td>1.05E-04</td><td>TIPARP</td><td>Nerve_Tibial</td><td>1.55E-02</td><td>1.30E-02</td></tr><tr><td>rs2128536</td><td>rs34620562</td><td>1.57E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>1.40E-02</td><td>1.48E-02</td></tr><tr><td>rs4680326</td><td>rs34620562</td><td>8.93E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>1.35E-02</td><td>1.41E-02</td></tr><tr><td>rs9875244</td><td>rs34620562</td><td>8.93E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>1.35E-02</td><td>1.36E-02</td></tr><tr><td>rs1032042</td><td>rs34620562</td><td>7.09E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>1.25E-02</td><td>1.71E-02</td></tr><tr><td>rs13082176</td><td>rs34620562</td><td>2.35E-04</td><td>TIPARP</td><td>Adipose_Subcutaneous</td><td>1.25E-02</td><td>1.01E-01</td></tr><tr><td>rs7616559</td><td>rs34620562</td><td>8.31E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>1.10E-02</td><td>1.31E-02</td></tr><tr><td>rs9829700</td><td>rs34620562</td><td>5.86E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>1.10E-02</td><td>1.67E-02</td></tr><tr><td>rs9867759</td><td>rs34620562</td><td>5.86E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>1.10E-02</td><td>1.69E-02</td></tr><tr><td>3:156782037_CTTTG_C</td><td>rs34620562</td><td>1.22E-04</td><td>TIPARP</td><td>Adipose_Subcutaneous</td><td>1.05E-02</td><td>7.78E-02</td></tr><tr><td>rs6765256</td><td>rs34620562</td><td>1.60E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>1.05E-02</td><td>1.42E-02</td></tr></table>
<table><tr><td>rs9839037</td><td>rs34620562</td><td>9.62E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>1.05E-02</td><td>1.57E-02</td></tr><tr><td>rs1384542</td><td>rs34620562</td><td>1.74E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>1.00E-02</td><td>1.42E-02</td></tr><tr><td>rs1482860</td><td>rs34620562</td><td>1.05E-04</td><td>TIPARP</td><td>Nerve_Tibial</td><td>1.00E-02</td><td>1.22E-02</td></tr><tr><td>rs4680336</td><td>rs34620562</td><td>1.74E-04</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>1.00E-02</td><td>1.47E-02</td></tr><tr><td>rs6769719</td><td>rs34620562</td><td>7.09E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>1.00E-02</td><td>1.66E-02</td></tr><tr><td>rs9818427</td><td>rs34620562</td><td>5.61E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>1.00E-02</td><td>1.49E-02</td></tr><tr><td>rs1482857</td><td>rs34620562</td><td>2.35E-04</td><td>TIPARP</td><td>Adipose_Subcutaneous</td><td>8.00E-03</td><td>1.01E-01</td></tr><tr><td>rs4574238</td><td>rs34620562</td><td>7.09E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>8.00E-03</td><td>1.46E-02</td></tr><tr><td>rs6802521</td><td>rs34620562</td><td>5.61E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>8.00E-03</td><td>1.63E-02</td></tr><tr><td>rs9840284</td><td>rs34620562</td><td>7.58E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>8.00E-03</td><td>1.21E-02</td></tr><tr><td>rs4680328</td><td>rs34620562</td><td>7.09E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>7.50E-03</td><td>1.58E-02</td></tr><tr><td>rs1600976</td><td>rs34620562</td><td>9.27E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>7.00E-03</td><td>1.39E-02</td></tr><tr><td>rs1482859</td><td>rs34620562</td><td>1.76E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>6.00E-03</td><td>9.72E-03</td></tr><tr><td>rs1905208</td><td>rs34620562</td><td>7.09E-05</td><td>TIPARP</td><td>Nerve_Tibial</td><td>5.50E-03</td><td>2.20E-02</td></tr><tr><td>rs6441109</td><td>rs34620562</td><td>2.34E-05</td><td>TIPARP</td><td>Muscle_Skeletal</td><td>4.50E-03</td><td>1.24E-02</td></tr><tr><td>rs11714203</td><td>rs75482782</td><td>7.38E-07</td><td>SGOL1</td><td>blood (BIOS_eQTL)</td><td>1.05E-02</td><td>4.01E-01</td></tr><tr><td>rs9842862</td><td>rs34620562</td><td>2.14E-04</td><td>KCNAB1</td><td>Whole_Blood</td><td>1.65E-02</td><td>7.55E-03</td></tr><tr><td>rs75482782</td><td>rs75482782</td><td>1.88E-08</td><td>KAT2B</td><td>blood (eQTLGen_cis)</td><td>9.69E-01</td><td>2.28E-01</td></tr><tr><td>rs11714203</td><td>rs75482782</td><td>4.02E-06</td><td>KAT2B</td><td>blood (eQTLGen_cis)</td><td>1.05E-02</td><td>4.01E-01</td></tr><tr><td>rs11636628</td><td>rs11636628</td><td>6.00E-19</td><td>CHSY1</td><td>blood (eQTLGen_cis)</td><td>7.50E-03</td><td>1.09E-03</td></tr></table>
# A.1 Heritability

## A.1.1 LD score regression

Using a LD score regression for IHI heritability in the left hemisphere, the total observed scale $h^2$ was of 0.2403 with a standard deviation of 0.0225. Lambda GC was of 1.1207, the mean $\chi^2$ was of 1.1488, the intercept of 1.0039 (SE of 0.0083) and the ratio of 0.026 (SE of 0.0556). Using a LD score regression for IHI heritability in the left hemisphere, the total observed scale $h^2$ was of 0.19 with a standard deviation of 0.0197. Lambda GC was of 1.0988, the mean $\chi^2$ was of 1.1218, the intercept of 1.0065 (SE of 0.0076) and the ratio of 0.0537 (0.0628).

## A.1.2 GCTA GREML

Studying heritability with GCTA summary statistics provided the results shown in tables A7 and A8.

<table><caption>**Table A7. Heritability results using a Linear mixed model (GREML) in the left hemisphere:**
Results are shown as variance and SE for genetic origin, environmental origin, complete explained origin. Further information includes log likelihood, LRT, degrees of freedom, the associated p value and the sample size</caption><thead><tr><th>Source</th><th>Variance</th><th>SE</th></tr></thead><tbody><tr><td>V(G)</td><td>0.228721</td><td>0.013648</td></tr><tr><td>V(e)</td><td>0.720331</td><td>0.013492</td></tr><tr><td>Vp</td><td>0.949052</td><td>0.007978</td></tr><tr><td>V(G)/Vp</td><td>0.240999</td><td>0.013883</td></tr><tr><td>logL</td><td>-13664.680</td><td></td></tr><tr><td>logL0</td><td>-13843.680</td><td></td></tr><tr><td>LRT</td><td>358.000</td><td></td></tr><tr><td>df</td><td>1</td><td></td></tr><tr><td>Pval</td><td>0</td><td></td></tr><tr><td>n</td><td>29234</td><td></td></tr></tbody></table>
<table><caption>**Table A8. Heritability results using GREML (right):** Results are shown as variance and SE for genetic origin, environmental origin, complete explained origin. Further information includes log likelihood, LRT, degrees of freedom, the associated p value and the sample size</caption><thead><tr><th>Source</th><th>Variance</th><th>SE</th></tr></thead><tbody><tr><td>V(G)</td><td>0.095255</td><td>0.006828</td></tr><tr><td>V(e)</td><td>0.391726</td><td>0.006984</td></tr><tr><td>Vp</td><td>0.486981</td><td>0.004072</td></tr><tr><td>V(G)/Vp</td><td>0.195603</td><td>0.013688</td></tr><tr><td>logL</td><td>-3983.061</td><td></td></tr><tr><td>logL0</td><td>-4100.934</td><td></td></tr><tr><td>LRT</td><td>235.746</td><td></td></tr><tr><td>df</td><td>1</td><td></td></tr><tr><td>Pval</td><td>0</td><td></td></tr><tr><td>n</td><td>29234</td><td></td></tr></tbody></table>
## A.2 Twin study

The results obtained using ACE and ADE models computed using the QTIM and QTAB datasets are shown in table A9

<table><caption>**Table A9.** ACE/ADE models: Results are shown for ACE, ADE AE and CE models. A, C/D and E components are shown alongside PE, delta.df, X.2LL, p values and AIC.</caption><thead><tr><th>hemisphere</th><th>Model</th><th>A</th><th>C/D</th><th>E</th><th>PE</th><th>delta.df</th><th>X.2LL</th><th>p.Valves</th><th>AIC</th></tr></thead><tbody><tr><td>IHI_L</td><td>ACE</td><td>0.18 [ 0 , 0.42 ]</td><td>0.14 [ 0 , 0.34 ]</td><td>0.68 [ 0.58 , 0.79 ]</td><td>7</td><td></td><td>3459.21</td><td>-</td><td>3459.21</td></tr><tr><td>IHI_L</td><td>ADE</td><td>0.34 [ 0.24 , 0.44 ]</td><td>0 [ 0 , 0.31 ]</td><td>0.66 [ 0.56 , 0.76 ]</td><td>7</td><td></td><td>3460.32</td><td>-</td><td>3460.32</td></tr><tr><td>IHI_L</td><td>AE</td><td>0.34 [ 0.24 , 0.44 ]</td><td>-</td><td>0.66 [ 0.56 , 0.76 ]</td><td>6</td><td>1</td><td>3460.32</td><td>0.291</td><td>3460.32</td></tr><tr><td>IHI_L</td><td>CE</td><td>-</td><td>0.27 [ 0.21 , 0.35 ]</td><td>0.73 [ 0.65 , 0.81 ]</td><td>6</td><td>1</td><td>3460.52</td><td>0.251</td><td>3460.52</td></tr><tr><td>IHI_R</td><td>ACE</td><td>0.37 [ 0.1 , 0.46 ]</td><td>0 [ 0 , 0.21 ]</td><td>0.63 [ 0.54 , 0.73 ]</td><td>7</td><td></td><td>2989.29</td><td>-</td><td>2989.29</td></tr><tr><td>IHI_R</td><td>ADE</td><td>0.3 [ 0 , 0.46 ]</td><td>0.08 [ 0 , 0.46 ]</td><td>0.62 [ 0.53 , 0.73 ]</td><td>7</td><td></td><td>2989.2</td><td>-</td><td>2989.2</td></tr><tr><td>IHI_R</td><td>AE</td><td>0.37 [ 0.27 , 0.46 ]</td><td>-</td><td>0.63 [ 0.54 , 0.73 ]</td><td>6</td><td>1</td><td>2989.29</td><td>1.000</td><td>2989.29</td></tr><tr><td>IHI_R</td><td>CE</td><td>-</td><td>0.28 [ 0.19 , 0.35 ]</td><td>0.72 [ 0.65 , 0.81 ]</td><td>6</td><td>1</td><td>2996.05</td><td>0.009</td><td>2996.05</td></tr></tbody></table>

According to these results, the AE and ADE models fits our data best in the left hemisphere and the ADE model fits our data best in the right hemisphere.