# Monte Carlo Modelization and Dosimetric Verification of C beamline components for Radiobiological studies

Jeevan Babu Amakkattu, Mateusz Sitarz, Violaine Vizcaino, François

Chevalier, Alain Méry

► To cite this version:

Jeevan Babu Amakkattu, Mateusz Sitarz, Violaine Vizcaino, François Chevalier, Alain Méry. Monte Carlo Modelization and Dosimetric Verification of C beamline components for Radiobiological studies. Joliot-Curie School - Radiations for Health, Sep 2024, St Pierre d'Oléron, France. . hal-04705560

HAL Id: hal-04705560

https://normandie-univ.hal.science/hal-04705560v1

Submitted on 23 Sep 2024

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# Monte Carlo Modelization and Dosimetric Verification of ¹²C beamline components for Radiobiological studies

The project involves Monte Carlo modelling of beamline components for current and future radiobiological studies with ¹²C ions at GANIL using GATE simulation kit

## Objectives

* Modelling and Characterising the Beam

* Design and optimisation of 2-D Range Modular or Ridge Filter and GRID Collimator

* Verification of Dose, LET and beam properties with experimental data

<figure><img src="image_2.png" /></figure>

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<figure><img src="image_4.png" /><figcaption>Figure a</figcaption></figure>

<caption>Figure b</caption>

Figure a: Gafchromic film in cell flask, Figure b: Measurement from Gafchromic cells indicating field size and homogeneity; Here field size is about 3 cm²

## RIDGE FILTER

* Transforms single energy into Spread Out Bragg Peak(SOBP) : creates conformal dose distribution in a target volume within a very short irradiation time (<<1 s) -> enables FLASH irradiation

* Combination of a range modulator and a ripple filter

* Fluence inhomogenieties in near field - studied against data of Radiochromic films

<figure><img src="image_5.png" /><figcaption>Figure 1</figcaption></figure>

<figure><img src="image_6.png" /><figcaption>Figure 2</figcaption></figure>

Figure 1: 3D printed Lucite Ridge Filter(RIFI) used to obtain SOBP of 2cm, Figure 2: Depth dose distribution of a 160 MeV proton beam portraying a SOBP using RIFI. Taken from 'Experimental Set-up for FLASH Proton Irradiation of Small Animals Using a Clinical System (2018)' Annalisa Patriarca et al.

## GRID COLLIMATOR

* For Spatially Fractionated Radiotherapy

* Study the influence of parameters like Center to Center distance(CTC), Collimator thickness, Beam width, Grid Factor(GF), Throughput, Valley to Peak Dose ratio(VPDR) etc

* To spare healthy tissues

<figure><img src="image_7.png" /><figcaption>Figure 3</figcaption></figure>

<figure><img src="image_8.png" /><figcaption>Figure 4</figcaption></figure>

Figure 3: Normalized dose profiles from EBT3 GFD of open and GRID irradiation together with normalized dose profiles from FLUKA MC simulations taken from Delmon Arous et al., Figure 4: Clinical GRID block commercially available from decimal, LLC, photo provided by decimal, LLC taken from Weisi Yan et al.

## Expected Results

* Preparation and validation of ¹²C beam model

* Design and optimisation of Ridge Filter and Grid Collimator

* Verification with experimental data

* Relate dose with particles/Gy of the beam source using the measurements of Gafchromic/Radiochromic films

## Future Scope

* Simulation of pencil beam scanning system

* Patient like radioactivity study

* Nanoparticles enhanced hadrontherapy simulations for in-vitro experiments with ¹²C beam

## Group

Jeevan Babu Amakkattu

Mateusz Sitarz

Violaine Vizcaino

François Chevalier

Alain Méry

<figure><img src="image_9.png" /></figure>

Erasmus Mundus
JMD on
Nuclear Physics

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