# Clonal Immunoglobulin Gene Rearrangement

National Cancer Institute

## Source

National Cancer Institute. Clonal Immunoglobulin Gene Rearrangement. NCI Thesaurus. Code C36443.

A DNA sequence rearrangement that results in the creation of a novel immunoglobulin. This process occurs during the differentiation of B-lymphocytes, such that individual B-cell progenitors, and their descendants, express an identical antibody molecule.