1564. Hedden P, Sponsel V. A century of gibberellin research. *J Plant Growth Regul.* 2015;34(4):740-760.

1565. Almasia NI, Nahirnak V, Hopp HE, Vazquez-Rovere C. Potato Snakin-1: an antimicrobial player of the trade-off between host defense and development. *Plant Cell Rep.* 2020;39(7):839-849.

1566. Gao S, Chu C. Gibberellin metabolism and signaling: targets for improving agronomic performance of crops. *Plant Cell Physiol.* 2020;61(11):1902-1911.

1567. Yeung H, Squire CJ, Yosaatmadja Y, et al. Radiation damage and racemic protein crystallography reveal the unique structure of the GASA/snakin protein superfamily. *Angew Chem Int Ed Engl.* 2016;55(28):7930-7933.

1568. Tuppo L, Alessandri C, Pasquariello MS, et al. Pomegranate cultivars: identification of the new IgE-binding protein pomma-clein and analysis of anti-oxidant variability. *J Agric Food Chem.* 2017;65(13):2702-2710.

1569. Inomata N, Miyagawa M, Aihara M. Gibberellin-regulated protein in Japanese apricot is an allergen cross-reactive to Pru p 7. *Immun Inflamm Dis.* 2017;5:469-479.

1570. Inomata N, Miyakawa M, Ikeda N, Oda K, Aihara M. Identification of gibberellin-regulated protein as a new allergen in orange allergy. *Clin Exp Allergy.* 2018;48(11):1509-1520.

1571. Shahali Y, Nicaise P, Brazdova A, et al. Complementarity between microarray and immunoblot for the comparative evaluation of IgE repertoire of french and italian cypress pollen allergic patients. *Folia Biol (Praha).* 2014;60(4):192-201.

1572. Sénéchal H, Santrucek J, Melcova M, et al. A new allergen family involved in pollen food associated syndrome: snakin/gibberellin regulated proteins. *J Allergy Clin Immunol.* 2018;141(1):411-414.

1573. Hugues B, Didierlaurent A, Charpin D. Cross-reactivity between cypress pollen and peach: a report of seven cases. *Allergy.* 2006;61(10):1241-1243.

1574. Martinez S, Gouitaa M, Tummino C, Chanez P, Charpin D. The cypress/citrus syndrome. *Rev Fr Allergol.* 2015;55(4):305-307.

1575. Sénéchal H, Charpin D, Couderc R, Poncet P. Gibberellin-regulated proteins and the enigma of the « missing link ». *Rev Fr Allergol.* 2018;58(6):63-67.

1576. Poncet P, Aizawa T, Senechal H. The subtype of Cupressaceae pollinosis associated with Pru p 7 sensitization is characterized by a sensitization to a cross-reactive gibberellin-regulated protein in cypress pollen: BP14. *Clin Exp Allergy.* 2019;49(8):1163-1166.

1577. Iizuka T, Takei M, Saito Y, et al. Gibberellin-regulated protein sensitization in Japanese cedar (*Cryptomeria japonica*) pollen allergic Japanese cohorts. *Allergy.* 2021;76:2297-2302.

1578. Poncet P, Senechal H, Charpin D. Update on pollen-food allergy syndrome. *Expert Rev Clin Immunol.* 2020;16(6):561-578.

1579. Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. *Mol Biol Evol.* 1987;4:406-425.

1580. Kumar S, Stecher G, Li M, et al. MEGA X: molecular evolutionary genetics analysis across computing platforms. *Mol Biol Evol.* 2018;35:1547-1549.

1581. Hotta A, Inomata N, Tanegasima T, Oda K, Inoue Y, Aihara M. Case of food-dependent exercise-induced anaphylaxis due to peach with Pru p 7 sensitization. *J Dermatol.* 2016;43(2):222-223.

1582. Asero R, Celi G, Scala E. Labile plant food allergens: really so harmless? Case series and literature review. *Allergy.* 2020;75:1517-1518.

1583. Asero R, Aruanno A, Bresciani M, et al. Evaluation of two commercial peach extracts for skin prick testing in the diagnosis of hypersensitivity to lipid transfer protein. A multicenter study. *Eur Ann Allergy Clin Immunol.* 2020.

1584. Olszewski A, Pons L, Moutété F, et al. Isolation and characterization of proteic allergens in refined peanut oil. *Clin Exp Allergy.* 1998;28(7):850-859.

1585. Pons L, Olszewski A, Guéant JL. Characterization of the oligomeric behavior of a 16.5 kDa peanut oleosin by chromatography and electrophoresis of the iodinated form. *J Chromatogr B Biomed Sci Appl.* 1998;706(1):131-140.

1586. Pons L, Chery C, Romano A, Namour F, Artesani MC, Guéant JL. The 18 kDa peanut oleosin is a candidate allergen for IgE-mediated reactions to peanuts. *Allergy.* 2002;57(Suppl 72):88-93.

1587. Li M, Smith LJ, Clark DC, Wilson R, Murphy DJ. Secondary structures of a new class of lipid body proteins from oilseeds. *J Biol Chem.* 1992;267(12):8245-8253.

1588. Jappe U, Schwager C. Relevance of lipophilic allergens in food allergy diagnosis. *Curr Allergy Asthma Rep.* 2017;17(9):61.

1589. Lin LJ, Tzen JT. Two distinct steroleosins are present in seed oil bodies. *Plant Physiol Biochem.* 2004;42(7-8):601-608.

1590. Tzen J, Wang M, Chen J, Lin L, Chen M. Seed oil body proteins: oleosin,caleosin, and steroleosin. *Curr Topics Biochem Res.* 2003;5:133-139.

1591. Frandsen GI, Mundy J, Tzen JT. Oil bodies and their associated proteins, oleosin andcaleosin. *Physiologia Plantarum.* 2001;112(3):301-307.

1592. Murphy DJ, Keen JN, Osullivan JN, et al. A class of amphipathic proteins associated with lipid storage bodies in plants. Possible similarities with animal serum apolipoproteins. *Biochim Biophys Acta.* 1991;1088(1):86-94.

1593. Leprince OVAA, Pritchard H, et al. Oleosins prevent oil-body coalescence during seed imbibition as suggested by a low-temperature scanning electron microscope study of desiccation-tolerant and-sensitive oilseeds. *Planta.* 1997;204(1):109-119. doi:10.1007/s004250050236

1594. Tzen JT, Lai YK, Chan KL, Huang AH. Oleosin isoforms of high and low molecular weights are present in the oil bodies of diverse seed species. *Plant Physiol.* 1990;94(3):1282-1289.

1595. www.allergen.org.

1596. Akkerdaas JH, Schocker F, Vieths S, et al. Cloning of oleosin, a putative new hazelnut allergen, using a hazelnut cDNA library. *Mol Nutr Food Res.* 2006;50(1):18-23.

1597. Nebbia S, Lamberti C, Cirrincione S, et al. Oleosin Cor a 15 is a novel allergen for Italian hazelnut allergic children. *Pediatr Allergy Immunol.* 2021;32(8):1743-1755.

1598. Schwager C, Kull S, Krause S, et al. Development of a novel strategy to isolate lipophilic allergens (oleosins) from peanuts. *PLoS One.* 2015;10(4):e0123419.

1599. Kobayashi S, Katsuyama S, Wagatsuma T, Okada S, Tanabe S. Identification of a new IgE-binding epitope of peanut oleosin that cross-reacts with buckwheat. *Biosci Biotechnol Biochem.* 2012;76(6):1182-1188.

1600. Chen F, Li H, Fan X, et al. Identification of a Novel Major Allergen in Buckwheat Seeds: Fag t 6. *J Agric Food Chem.* 2021;69(45):13315-13322.

1601. Leduc V, Moneret-Vautrin DA, Tzen JT, Morisset M, Guerin L, Kanny G. Identification of oleosins as major allergens in sesame seed allergic patients. *Allergy.* 2006;61(3):349-356.

1602. Commission Directive 2006/142/EC of 22 December 2006 amending Annex IIIa of Directive 2000/13/EC of the European Parliament and of the Council listing the ingredients which must under all circumstances appear on the labelling of foodstuffs. *Off J Eur Union.* 2006;368(110):110-111.

1603. Ehlers AM, Rossnagel M, Brix B, et al. Sesame oleosins are minor allergens. *Clin Transl Allergy.* 2019;9:32.

1604. Behrends J, Schwager C, Hein M, Scholzen T, Kull S, Jappe U. Innovative robust basophil activation test using a novel gating strategy reliably diagnosing allergy with full automation. *Allergy.* 2021;76(12):3776-3788.

1605. Della-Torre E, Pignatti P, Yacoub MR, Sabbadini MG, Colombo G. *In vivo* tests with "Tahini" sauce: new allergenic source to evaluate IgE-mediated hypersensitivity to sesame. *Ann Allergy Asthma Immunol.* 2013;110(3):209-210.
1564. Hedden P, Sponsel V. A century of gibberellin research. *J Plant Growth Regul.* 2015;34(4):740-760.

1565. Almasia NI, Nahirnak V, Hopp HE, Vazquez-Rovere C. Potato Snakin-1: an antimicrobial player of the trade-off between host defense and development. *Plant Cell Rep.* 2020;39(7):839-849.

1566. Gao S, Chu C. Gibberellin metabolism and signaling: targets for improving agronomic performance of crops. *Plant Cell Physiol.* 2020;61(11):1902-1911.

1567. Yeung H, Squire CJ, Yosaatmadja Y, et al. Radiation damage and racemic protein crystallography reveal the unique structure of the GASA/snakin protein superfamily. *Angew Chem Int Ed Engl.* 2016;55(28):7930-7933.

1568. Tuppo L, Alessandri C, Pasquariello MS, et al. Pomegranate cultivars: identification of the new IgE-binding protein pomma-clein and analysis of anti-oxidant variability. *J Agric Food Chem.* 2017;65(13):2702-2710.

1569. Inomata N, Miyagawa M, Aihara M. Gibberellin-regulated protein in Japanese apricot is an allergen cross-reactive to Pru p 7. *Immun Inflamm Dis.* 2017;5:469-479.

1570. Inomata N, Miyakawa M, Ikeda N, Oda K, Aihara M. Identification of gibberellin-regulated protein as a new allergen in orange allergy. *Clin Exp Allergy.* 2018;48(11):1509-1520.

1571. Shahali Y, Nicaise P, Brazdova A, et al. Complementarity between microarray and immunoblot for the comparative evaluation of IgE repertoire of french and italian cypress pollen allergic patients. *Folia Biol (Praha).* 2014;60(4):192-201.

1572. Sénéchal H, Santrucek J, Melcova M, et al. A new allergen family involved in pollen food associated syndrome: snakin/gibberellin regulated proteins. *J Allergy Clin Immunol.* 2018;141(1):411-414.

1573. Hugues B, Didierlaurent A, Charpin D. Cross-reactivity between cypress pollen and peach: a report of seven cases. *Allergy.* 2006;61(10):1241-1243.

1574. Martinez S, Gouitaa M, Tummino C, Chanez P, Charpin D. The cypress/citrus syndrome. *Rev Fr Allergol.* 2015;55(4):305-307.

1575. Sénéchal H, Charpin D, Couderc R, Poncet P. Gibberellin-regulated proteins and the enigma of the « missing link ». *Rev Fr Allergol.* 2018;58(6):63-67.

1576. Poncet P, Aizawa T, Senechal H. The subtype of Cupressaceae pollinosis associated with Pru p 7 sensitization is characterized by a sensitization to a cross-reactive gibberellin-regulated protein in cypress pollen: BP14. *Clin Exp Allergy.* 2019;49(8):1163-1166.

1577. Iizuka T, Takei M, Saito Y, et al. Gibberellin-regulated protein sensitization in Japanese cedar (*Cryptomeria japonica*) pollen allergic Japanese cohorts. *Allergy.* 2021;76:2297-2302.

1578. Poncet P, Senechal H, Charpin D. Update on pollen-food allergy syndrome. *Expert Rev Clin Immunol.* 2020;16(6):561-578.

1579. Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. *Mol Biol Evol.* 1987;4:406-425.

1580. Kumar S, Stecher G, Li M, et al. MEGA X: molecular evolutionary genetics analysis across computing platforms. *Mol Biol Evol.* 2018;35:1547-1549.

1581. Hotta A, Inomata N, Tanegasima T, Oda K, Inoue Y, Aihara M. Case of food-dependent exercise-induced anaphylaxis due to peach with Pru p 7 sensitization. *J Dermatol.* 2016;43(2):222-223.

1582. Asero R, Celi G, Scala E. Labile plant food allergens: really so harmless? Case series and literature review. *Allergy.* 2020;75:1517-1518.

1583. Asero R, Aruanno A, Bresciani M, et al. Evaluation of two commercial peach extracts for skin prick testing in the diagnosis of hypersensitivity to lipid transfer protein. A multicenter study. *Eur Ann Allergy Clin Immunol.* 2020.

1584. Olszewski A, Pons L, Moutété F, et al. Isolation and characterization of proteic allergens in refined peanut oil. *Clin Exp Allergy.* 1998;28(7):850-859.

1585. Pons L, Olszewski A, Guéant JL. Characterization of the oligomeric behavior of a 16.5 kDa peanut oleosin by chromatography and electrophoresis of the iodinated form. *J Chromatogr B Biomed Sci Appl.* 1998;706(1):131-140.

1586. Pons L, Chery C, Romano A, Namour F, Artesani MC, Guéant JL. The 18 kDa peanut oleosin is a candidate allergen for IgE-mediated reactions to peanuts. *Allergy.* 2002;57(Suppl 72):88-93.

1587. Li M, Smith LJ, Clark DC, Wilson R, Murphy DJ. Secondary structures of a new class of lipid body proteins from oilseeds. *J Biol Chem.* 1992;267(12):8245-8253.

1588. Jappe U, Schwager C. Relevance of lipophilic allergens in food allergy diagnosis. *Curr Allergy Asthma Rep.* 2017;17(9):61.

1589. Lin LJ, Tzen JT. Two distinct steroleosins are present in seed oil bodies. *Plant Physiol Biochem.* 2004;42(7-8):601-608.

1590. Tzen J, Wang M, Chen J, Lin L, Chen M. Seed oil body proteins: oleosin, calcosin, and steroleosin. *Curr Topics Biochem Res.* 2003;5:133-139.

1591. Frandsen GI, Mundy J, Tzen JT. Oil bodies and their associated proteins, oleosin and calcosin. *Physiologia Plantarum.* 2001;112(3):301-307.

1592. Murphy DJ, Keen JN, Osullivan JN, et al. A class of amphipathic proteins associated with lipid storage bodies in plants. Possible similarities with animal serum apolipoproteins. *Biochim Biophys Acta.* 1991;1088(1):86-94.

1593. Leprince OVAA, Pritchard H, et al. Oleosins prevent oil-body coalescence during seed imbibition as suggested by a low-temperature scanning electron microscope study of desiccation-tolerant and-sensitive oilseeds. *Planta.* 1997;204(1):109-119. doi:10.1007/s004250050236

1594. Tzen JT, Lai YK, Chan KL, Huang AH. Oleosin isoforms of high and low molecular weights are present in the oil bodies of diverse seed species. *Plant Physiol.* 1990;94(3):1282-1289.

1595. www.allergen.org.

1596. Akkerdaas JH, Schocker F, Vieths S, et al. Cloning of oleosin, a putative new hazelnut allergen, using a hazelnut cDNA library. *Mol Nutr Food Res.* 2006;50(1):18-23.

1597. Nebbia S, Lamberti C, Cirrincione S, et al. Oleosin Cor a 15 is a novel allergen for Italian hazelnut allergic children. *Pediatr Allergy Immunol.* 2021;32(8):1743-1755.

1598. Schwager C, Kull S, Krause S, et al. Development of a novel strategy to isolate lipophilic allergens (oleosins) from peanuts. *PLoS One.* 2015;10(4):e0123419.

1599. Kobayashi S, Katsuyama S, Wagatsuma T, Okada S, Tanabe S. Identification of a new IgE-binding epitope of peanut oleosin that cross-reacts with buckwheat. *Biosci Biotechnol Biochem.* 2012;76(6):1182-1188.

1600. Chen F, Li H, Fan X, et al. Identification of a Novel Major Allergen in Buckwheat Seeds: Fag t 6. *J Agric Food Chem.* 2021;69(45):13315-13322.

1601. Leduc V, Moneret-Vautrin DA, Tzen JT, Morisset M, Guerin L, Kanny G. Identification of oleosins as major allergens in sesame seed allergic patients. *Allergy.* 2006;61(3):349-356.

1602. Commission Directive 2006/142/EC of 22 December 2006 amending Annex IIIa of Directive 2000/13/EC of the European Parliament and of the Council listing the ingredients which must under all circumstances appear on the labelling of foodstuffs. *Off J Eur Union.* 2006;368(110):110-111.

1603. Ehlers AM, Rossnagel M, Brix B, et al. Sesame oleosins are minor allergens. *Clin Transl Allergy.* 2019;9:32.

1604. Behrends J, Schwager C, Hein M, Scholzen T, Kull S, Jappe U. Innovative robust basophil activation test using a novel gating strategy reliably diagnosing allergy with full automation. *Allergy.* 2021;76(12):3776-3788.

1605. Della-Torre E, Pignatti P, Yacoub MR, Sabbadini MG, Colombo G. *In vivo* tests with "Tahini" sauce: new allergenic source to evaluate IgE-mediated hypersensitivity to sesame. *Ann Allergy Asthma Immunol.* 2013;110(3):209-210.
1606. Majsiak E, Choina M, Miśkiewicz K, Doniec Z, Kurzawa R. Oleosins: a short allergy review. *Adv Exp Med Biol.* 2021;1324:51-55.

1607. Anemüller WFY, Angün O, et al. Relevante sensibilisierung gegen risikoallergene der erdnuss bei einem säugling mit atopischen. *Ekzem Allergologie.* 2013;36:397-403.

1608. Teodorowicz M, Terlouw RJ, Jansen A, Savelkoul HF, Ruinemans-Koerts J. Immunological characterization of Dutch sesame seed-allergic patients. *Int Arch Allergy Immunol.* 2016;169(1):13-22.

1609. Das Dores S, Chopin C, Villaume C, Fleurence J, Guéant JL. A new oligomeric parvalbumin allergen of Atlantic cod (Gad ml) encoded by a gene distinct from that of Gad cl. *Allergy.* 2002;57:79-83.

1610. Moraes AH, Ackerbauer D, Kostadinova M, et al. Solution and high-pressure NMR studies of the structure, dynamics, and stability of the cross-reactive allergenic cod parvalbumin Gad m 1. *Proteins.* 2014;82:3032-3042.

1611. Schwaller B. The continuing disappearance of "pure" Ca2+ buffers. *Cell Mol Life Sci.* 2009;66:275-300.

1612. Kobayashi A, Tanaka H, Hamada Y, Ishizaki S, Nagashima Y, Shiomi K. Comparison of allergenicity and allergens between fish white and dark muscles. *Allergy.* 2006;61:357-363.

1613. Perez-Gordo M, Lin J, Bardina L, et al. Epitope mapping of Atlantic salmon major allergen by peptide microarray immunoassay. *Int Arch Allergy Immunol.* 2011;157:31-40.

1614. Freidl R, Gstoettner A, Baranyi U, et al. Blocking antibodies induced by immunization with a hypoallergenic parvalbumin mutant reduce allergic symptoms in a mouse model of fish allergy. *J Allergy Clin Immunol.* 2017;139:1897-1905.

1615. Patriarca G, Nucera E, Pollastrini E, et al. Oral specific desensitization in food-allergic children. *Dig Dis Sci.* 2007;52:1662-1672.

1616. Hilger C, Thill L, Grigioni F, et al. IgE-antibodies of fish allergic patients cross-react with frog parvalbumin. *Allergy.* 2004;59:653-660.

1617. Imakiire R, Fujisawa T, Nagao M, et al. Basophil activation test based on CD203C expression in the diagnosis of fish allergy. *Allergy Asthma Immunol Res.* 2020;12:641-652.

1618. Kalic T, Ellinger I, Kamath SD, et al. Fish-derived low molecular weight components modify bronchial epithelial barrier properties and release of pro-inflammatory cytokines. *Mol Immunol.* 2019;112:140-150.

1619. Untersmayr E, Poulsen LK, Platzer MH, et al. The effects of gastric digestion on codfish allergenicity. *J Allergy Clin Immunol.* 2005;115:377-382.

1620. Raposo De Magalhães C, Schrama D, Fonseca F, et al. Effect of EDTA enriched diets on farmed fish allergenicity and muscle quality; a proteomics approach. *Food Chem.* 2020;305:125508.

1621. Kuehn A, Hutt-Kempf E, Hilger C, Hentges F. Clinical monosen sitivity to salmonid fish linked to specific IgE-epitopes on salmon and trout beta-parvalbumins. *Allergy.* 2011;66:298-299.

1622. Haroun-Díaz E, Blanca-López N, Vázquez de la Torre M, et al. Severe anaphylaxis due to crocodile-meat allergy exhibiting wide cross-reactivity with fish allergens. *J Allergy Clin Immunol Pract.* 2018;6:669-670.

1623. Asturias JA, Ibarrola I, Eseverri JL, et al. PCR-based cloning and immunological characterization of *Parietaria judaica* pollen profilin. *J Investig Allergol Clin Immunol.* 2004;14:43-48.

1624. Szewzyk R, Becker K, Hünken A, et al. Kinder-Umwelt-Survey (KUS) 2003/06 Sensibilisierung gegenüber Innenraum Schimmelpilzen. Schriftreihe Umwelt & Gesundheit im Auftrag des Umweltbundesamt; 2011.

1625. Gent JF, Kezik JM, Hill ME, et al. Household mold and dust allergens: exposure, sensitisation and childhood asthma morbidity. *Environ Res.* 2012;118:86-93. doi:10.1016/j.envres.2012.07.005

1626. Forkel S, Beutner C, Schröder SS, et al. Sensitisation against fungi in patients with airway allergies over 20 years in Germany. *Int Arch Allergy Immunol.* 2021;182:515-523. doi:10.1159/000512230

1627. Toppila-Salmi S, Huhtala H, Karjalainen J, et al. Sensitisation pattern affects the asthma risk in Finnish adult population. *Allergy.* 2015;70:1112-1120. doi:10.1111/all.12670

1628. Crameri R, Zeller S, Glaser AG, et al. Cross-reactivity among fungal allergens: a clinically relevant phenomenon? *Mycoses.* 2009;52:99-106. doi:10.1111/j.1439-0507.2008.01644.x

1629. Michalska K, Fernandes H, Sikorski M, Jaskolski M. Crystal structure of Hyp-1, a St. John's wort protein implicated in the biosynthesis of hypericin. *J Struct Biol.* 2010;169(2):161-171. doi:10.1016/j.jsb.2009.10.008

1630. Sliwiak J, Dauter Z, Jaskolski M. Crystal structure of Hyp-1, a *Hypericum perforatum* PR-10 protein, in complex with melatonin. *Front Plant Sci.* 2016;7:668. doi:10.3389/fpls.2016.00668

1631. Araujo RN, Franco PF, Rodrigues H, et al. Amblyomma sculp-tum tick saliva: α-Gal identification, antibody response and pos-sible association with red meat allergy in Brazil. *Int J Parasitol.* 2016;46(3):213-220. doi:10.1016/j.ijpara.2015.12.005

1632. Chinuki Y, Ishiwata K, Yamaji K, et al. Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan. *Allergy.* 2016;71(3):421-425.

1633. Hilger C, Fischer J, Swiontek K, et al. Two galactose-α-1,3-galactose carrying peptidases from pork kidney mediate anaphylactogenic responses in delayed meat allergy. *Allergy.* 2016;71(5):711-719. doi:10.1111/all.12835

1634. Apostolovic D, Tran TA, Hamsten C, et al. Immunoproteomics of processed beef proteins reveal novel galactose-α-1,3-galactose-containing allergens. *Allergy.* 2014;69(10):1308-1315. doi:10.1111/all.12462

1635. Schwager C, Kull S, Krause S, et al. Development of a novel strategy to isolate lipophilic allergens from peanuts. *Plos One.* 2015;10(4):e0123419. doi:10.1371/journal.pone.0123419

1636. Incorvaia C, Ridolo E, Mauro M, et al. Allergen immunotherapy for birch-apple syndrome: what do we know? *Immunotherapy.* 2017;9(15):1271-1278.

1637. Arero R. Is there a role for birch pollen immunotherapy on concomitant food allergy? *Curr Treat Options Allergy.* 2015;2(2):83-89.

1638. Vidal C, Armisén M, Monsalve R, et al. Anaphylaxis to Vespa velutina nigrithorax: pattern of sensitization for an emerging problem in Western Countries. *J Investig Allergol Clin Immunol.* 2021;31:228-235.

1639. Fauquert J, Rondon C, Calder V, Silva D, Kvenshagen BK. Conjunctival allergen provocation test: guidelines for daily practice. *Allergy.* 2017;72:43-54.

1640. Jiang C, Fan X, Li M, et al. Characterization of Der f 29, a new allergen from dermatophagoides farinae. *Am J Transl Res.* 2015;7:1303-1313.

1641. Gracia IE, Testera A, Rondon C. Medical algorithm: diagnosis and treatment of local allergic rhinitis. *Allergy.* 2021;2927-2930.

1642. Nouri HR, Varasteh A, Vahedi F, Chamani J, Afsharzadeh D, Sankian M. Constructing a hybrid molecule with low capacity of IgE binding from Chenopodium album pollen allergens. *Immunol Lett.* 2012;144:67-77.

1643. Tort MJ, Ornberg R, Lay B, Soong F, Salapatek AM. 55 Ocular signs and symptoms elicited by a naturalistic allergen challenge in an environmental exposure chamber model versus a direct allergen instillation model. *World Allergy Organ J.* 2012;5:S35.

1644. Godnic-Cvar J, Susani M, Breiteneder H, et al. Recombinant Bet v 1, the major birch pollen allergen, induces hypersensitivity reactions equal to those induced by natural Bet v 1 in the airways of patients allergic to tree pollen. *J Allergy Clin Immunol.* 1997;99:354-359.

1645. Fischl A, Eckrich J, Passlack V, et al. Comparison of bronchial and nasal allergen provocation in children and adolescents with bronchial asthma and house dust mite sensitization. *Pediatr Allergy Immunol.* 2020;31:143-149.

1646. Käck U, van Hage M, Grönlund H, Lilja G, Asarnoj A, Konradsen JR. Allergic sensitization to lipocalins reflects asthma morbidity in dog
1606. Majsiak E, Choina M, Miśkiewicz K, Doniec Z, Kurzawa R. Oleosins: a short allergy review. *Adv Exp Med Biol.* 2021;1324:51-55.

1607. Anemüller WFY, Angün O, et al. Relevante sensibilisierung gegen risikoallergene der erdnuss bei einem säugling mit atopischen. *Ekzem Allergologie.* 2013;36:397-403.

1608. Teodorowicz M, Terlouw RJ, Jansen A, Savelkoul HF, Ruinemans-Koerts J. Immunological characterization of Dutch sesame seed-allergic patients. *Int Arch Allergy Immunol.* 2016;169(1):13-22.

1609. Das Dores S, Chopin C, Villaume C, Fleurence J, Guéant JL. A new oligomeric parvalbumin allergen of Atlantic cod (Gad ml) encoded by a gene distinct from that of Gad cl. *Allergy.* 2002;57:79-83.

1610. Moraes AH, Ackerbauer D, Kostadinova M, et al. Solution and high-pressure NMR studies of the structure, dynamics, and stability of the cross-reactive allergenic cod parvalbumin Gad m 1. *Proteins.* 2014;82:3032-3042.

1611. Schwaller B. The continuing disappearance of "pure" Ca2+ buffers. *Cell Mol Life Sci.* 2009;66:275-300.

1612. Kobayashi A, Tanaka H, Hamada Y, Ishizaki S, Nagashima Y, Shiomi K. Comparison of allergenicity and allergens between fish white and dark muscles. *Allergy.* 2006;61:357-363.

1613. Perez-Gordo M, Lin J, Bardina L, et al. Epitope mapping of Atlantic salmon major allergen by peptide microarray immunoassay. *Int Arch Allergy Immunol.* 2011;157:31-40.

1614. Freidl R, Gstoettner A, Baranyi U, et al. Blocking antibodies induced by immunization with a hypoallergenic parvalbumin mutant reduce allergic symptoms in a mouse model of fish allergy. *J Allergy Clin Immunol.* 2017;139:1897-1905.

1615. Patriarca G, Nucera E, Pollastrini E, et al. Oral specific desensitization in food-allergic children. *Dig Dis Sci.* 2007;52:1662-1672.

1616. Hilger C, Thill L, Grigioni F, et al. IgE-antibodies of fish allergic patients cross-react with frog parvalbumin. *Allergy.* 2004;59:653-660.

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1651. Kim EH, Andrew Bird J, Kulis M, et al. Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization. *J Allergy Clin Immunol*. 2011;127(3):640-646.e1.

1652. Nelson HS, Lahr J, Rule R, Bock A, Leung D. Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. *J Allergy Clin Immunol*. 1997;99(6 Pt 1):744-751.

1653. Vickery BP, Scurlock AM, Kulis M, et al. Sustained unresponsive-ness to peanut in subjects who have completed peanut oral immunotherapy. *J Allergy Clin Immunol*. 2014;133(2):468-475.

1654. Foo ACY, Thompson PM, Mueller GA. Removal and replacement of endogenous ligands from lipid-bound proteins and allergens. *J Vis Exp*. 2021;168. doi:10.3791/61780

1655. Borges JP, Barre A, Culerrier R, Archimbaud N, Didier A, Rouge P. How reliable is the structural prediction of IgE-binding epitopes of allergens? The case study of plant lipid transfer proteins. *Biochimie*. 2007;89(1):83-91. doi:10.1016/j.biochi.2006.09.012

1656. Dubiela P, Del Conte R, Cantini F, et al. Impact of lipid binding on the tertiary structure and allergenic potential of Jug r 3, the non-specific lipid transfer protein from walnut. *Sci Rep*. 2019;9(1):2007. doi:10.1038/s41598-019-38563-1

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1658. Westman M, Lupinek C, Bousquet J, et al. Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence. *J Allergy Clin Immunol*. 2015;135:1199-1206. e1191-1111.

1659. Berneder M, Bublin M, Hoffmann-Sommergruber K, Hawranek T, Lang R. Allergen chip diagnosis for soy-allergic patients: Gly m 4 as a marker for severe food-allergic reactions to soy. *Int Arch Allergy Immunol*. 2013;161:229-233.

1660. Komata T, Soderstrom L, Borres MP, Tachimoto H, Ebisawa M. Usefulness of wheat and soybean specific IgE antibody titers for the diagnosis of food allergy. *Allergol Int*. 2009;58:599-603.

1661. Mattsson L, Valcour A, Holmqvist M, Larsson H, Lidholm J. Cyclophilin - A novel cross-reactive determinant in peanut. *Clin Exp Allergy*. 2021;51:620-622.

1662. Martin PE, Eckert JK, Koplin JJ, et al. Which infants with eczema are at risk of food allergy? Results from a population-based cohort. *Clin Exp Allergy*. 2015;45:255-264.

1663. Niggemann B, Schmitz R, Schlaud M. The high prevalence of peanut sensitization in childhood is due to cross-reactivity to pollen. *Allergy*. 2011;66:980-981.

1664. Codreanu F, Collignon O, Roitel O, et al. A novel immunoassay using recombinant allergens simplifies peanut allergy diagnosis. *Int Arch Allergy Immunol*. 2011;154:216-226.

1665. Krause S, Reese G, Randow S, et al. Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population. *J Allergy Clin Immunol*. 2009;124:771-778.e775.

1666. Nilsson C, Berthold M, Mascialino B, Orme ME, Sjolander S, Hamilton RG. Accuracy of component-resolved diagnostics in peanut allergy: Systematic literature review and meta-analysis. *Pediatr Allergy Immunol*. 2020;31:303-314.

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1668. Voltolini S, Spigno F, Cioè A, et al. Bovine serum albumin: a double allergy risk. *Eur Ann Allergy Clin Immunol*. 2013;45(4):144-147.

1669. Hilger C, Swiontek K, Hentges F, et al. Occupational inhalant allergy to pork followed by food allergy to pork and chicken: sensitisation to hemoglobin and serum albumin. *Int Arch Allergy Immunol*. 2010;151(2):173-178. doi:10.1159/000236008

1670. Cheikh Rouhou S, Bachouch I, Racil H, et al. Choc anaphylactique à la viande de poulet [Anaphylaxis due to chicken meat]. *Rev Mal Respir*. 2012;29(1):98-100. doi:10.1016/j.rmr.2011.11.009

1671. Ashkenazy H, Abadi S, Martz E, et al. ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules. *Nucleic Acids Res*. 2016;44(W1):W344-W350. doi:10.1093/nar/gkw408

1672. Salo PM, Sever ML, Zeldin DC. Indoor allergens in school and day care environments. *J Allergy Clin Immunol*. 2009;124(2):185-194. doi:10.1016/j.jaci.2009.05.012

1673. Ballardini N, Nopp A, Hamsten C, et al. Anaphylactic reactions to novel foods: case report of a child with severe crocodile meat allergy. *Pediatrics*. 2017;139(4):e20161404. doi:10.1542/peds.2016-1404

1674. Crespo JF, Retzek M, Foetisch K, et al. Germin-like protein Cit s 1 and profilin Cit s 2 are major allergens in orange (Citrus sinensis) fruits. *Mol Nutr Food Res*. 2006;50:282-290.

1675. Mahesh PA, et al. Prevalence of food sensitization and probable food allergy among adults in India: the EuroPrevall INCO study. *Allergy*. 2016;71(7):1010-1019.

1676. Yu HL, Cao MJ, Cai QF, et al. Effects of different processing methods on digestibility of *Scylla paramamosain* allergen (tropomyosin). *Food Chem Toxicol*. 2011;49(4):791-798.

1677. Ayuso R, Grishina G, Ibáñez MD, et al. Sarcoplasmic calcium-binding protein is an EF-hand-type protein identified as a new shrimp allergen. *J Allergy Clin Immunol*. 2009;124(1):114-120.

1678. Ayuso R, Lehrer SB, Reese G. Identification of continuous, allergenic regions of the major shrimp allergen Pen a 1 (tropomyosin). *Int Arch Allergy Immunol*. 2002;127(1):27-37.

1679. Bauermeister K, Wangorsch A, Garoffo LP, et al. Generation of a comprehensive panel of crustacean allergens from the North Sea Shrimp Crangon crangon. *Mol Immunol*. 2011;48(15-16):1983-1992.

1680. Akimoto S, Yokooji T, Ogino R, et al. Identification of allergens for food-dependent exercise-induced anaphylaxis to shrimp. *Sci Rep*. 2021;11(1):5400.

1681. Arzt L, Bokanovic D, Schrautzer C, et al. Questionable diagnostic benefit of the commercially available panel of bee venom components. *Allergy*. 2017;72(9):1419-1422.

1682. Frick M, Müller S, Bantleon F, et al. rApi m 3 and rApi m 10 improve detection of honey bee sensitization in Hymenoptera venom-allergic patients with double sensitisation to honey bee and yellow jacket venom. *Allergy*. 2015;70(12):1665-1668.

1683. Hofmann SC, Pfender N, Weckesser S, et al. Reply: to PMID 21439627. *J Allergy Clin Immunol*. 2011;128(1):248.
dander sensitized children. *Clin Transl Allergy*. 2022;12(5):e12149.
doi:10.1002/clt2.12149

1647. Royer PJ, Emara M, Yang C, et al. The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity. *J Immunol*. 2010;185(3):1522-1531. doi:10.4049/jimmunol.10007745

1648. Hsu SC, Chen CH, Tsai SH, et al. Functional interaction of common allergens and a C-type lectin receptor, dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), on human dendritic cells. *J Biol Chem*. 2010;285(11):7903-7910. doi:10.1074/jbc.M109.058370

1649. Radauer C, Breiteneder H. Evolutionary biology of plant food allergens. *J Allergy Clin Immunol*. 2007;120(3):518-525. doi:10.1016/j.jaci.2007.07.024

1650. Nguyen-Kim H, San Clemente H, Laimer J, et al. The cell wall PAC (proline-rich, arabinogalactan proteins, conserved cysteines) domain-proteins are conserved in the green lineage. *Int J Mol Sci*. 2020;21(7):2488. doi:10.3390/ijms21072488

1651. Kim EH, Andrew Bird J, Kulis M, et al. Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization. *J Allergy Clin Immunol*. 2011;127(3):640-646.e1.

1652. Nelson HS, Lahr J, Rule R, Bock A, Leung D. Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. *J Allergy Clin Immunol*. 1997;99(6 Pt 1):744-751.

1653. Vickery BP, Scurlock AM, Kulis M, et al. Sustained unresponsive-ness to peanut in subjects who have completed peanut oral immunotherapy. *J Allergy Clin Immunol*. 2014;133(2):468-475.

1654. Foo ACY, Thompson PM, Mueller GA. Removal and replacement of endogenous ligands from lipid-bound proteins and allergens. *J Vis Exp*. 2021;168. doi:10.3791/61780

1655. Borges JP, Barre A, Culerrier R, Archimbaud N, Didier A, Rouge P. How reliable is the structural prediction of IgE-binding epitopes of allergens? The case study of plant lipid transfer proteins. *Biochimie*. 2007;89(1):83-91. doi:10.1016/j.biochi.2006.09.012

1656. Dubiela P, Del Conte R, Cantini F, et al. Impact of lipid binding on the tertiary structure and allergenic potential of Jug r 3, the non-specific lipid transfer protein from walnut. *Sci Rep*. 2019;9(1):2007. doi:10.1038/s41598-019-38563-1

1657. Ziska L, Knowlton K, Rogers C, et al. Recent warming by latitude associated with increased length of ragweed pollen season in central North America. *Proc Natl Acad Sci USA*. 2011;108(10):4248-4251. doi:10.1073/pnas.1014107108

1658. Westman M, Lupinek C, Bousquet J, et al. Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence. *J Allergy Clin Immunol*. 2015;135:1199-1206. e1191-1111.

1659. Berneder M, Bublin M, Hoffmann-Sommergruber K, Hawranek T, Lang R. Allergen chip diagnosis for soy-allergic patients: Gly m 4 as a marker for severe food-allergic reactions to soy. *Int Arch Allergy Immunol*. 2013;161:229-233.

1660. Komata T, Soderstrom L, Borres MP, Tachimoto H, Ebisawa M. Usefulness of wheat and soybean specific IgE antibody titers for the diagnosis of food allergy. *Allergol Int*. 2009;58:599-603.

1661. Mattsson L, Valcour A, Holmqvist M, Larsson H, Lidholm J. Cyclophilin - A novel cross-reactive determinant in peanut. *Clin Exp Allergy*. 2021;51:620-622.

1662. Martin PE, Eckert JK, Koplin JJ, et al. Which infants with eczema are at risk of food allergy? Results from a population-based cohort. *Clin Exp Allergy*. 2015;45:255-264.

1663. Niggemann B, Schmitz R, Schlaud M. The high prevalence of peanut sensitization in childhood is due to cross-reactivity to pollen. *Allergy*. 2011;66:980-981.

1664. Codreanu F, Collignon O, Roitel O, et al. A novel immunoassay using recombinant allergens simplifies peanut allergy diagnosis. *Int Arch Allergy Immunol*. 2011;154:216-226.

1665. Krause S, Reese G, Randow S, et al. Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population. *J Allergy Clin Immunol*. 2009;124:771-778.e775.

1666. Nilsson C, Berthold M, Mascialino B, Orme ME, Sjolander S, Hamilton RG. Accuracy of component-resolved diagnostics in peanut allergy: Systematic literature review and meta-analysis. *Pediatr Allergy Immunol*. 2020;31:303-314.

1667. Spitzauer S, Pandjaitan B, Söregi G, et al. IgE cross-reactivities against albumins in patients allergic to animals. *J Allergy Clin Immunol*. 1995;96(6 Pt 1):951-959. doi:10.1016/s0091-6749(95)70233-4

1668. Voltolini S, Spigno F, Cioè A, et al. Bovine serum albumin: a double allergy risk. *Eur Ann Allergy Clin Immunol*. 2013;45(4):144-147.

1669. Hilger C, Swiontek K, Hentges F, et al. Occupational inhalant allergy to pork followed by food allergy to pork and chicken: sensitisation to hemoglobin and serum albumin. *Int Arch Allergy Immunol*. 2010;151(2):173-178. doi:10.1159/000236008

1670. Cheikh Rouhou S, Bachouch I, Racil H, et al. Choc anaphylactique à la viande de poulet [Anaphylaxis due to chicken meat]. *Rev Mal Respir*. 2012;29(1):98-100. doi:10.1016/j.rmr.2011.11.009

1671. Ashkenazy H, Abadi S, Martz E, et al. ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules. *Nucleic Acids Res*. 2016;44(W1):W344-W350. doi:10.1093/nar/gkw408

1672. Salo PM, Sever ML, Zeldin DC. Indoor allergens in school and day care environments. *J Allergy Clin Immunol*. 2009;124(2):185-194. doi:10.1016/j.jaci.2009.05.012

1673. Ballardini N, Nopp A, Hamsten C, et al. Anaphylactic reactions to novel foods: case report of a child with severe crocodile meat allergy. *Pediatrics*. 2017;139(4):e20161404. doi:10.1542/peds.2016-1404

1674. Crespo JF, Retzek M, Foetisch K, et al. Germin-like protein Cit s 1 and profilin Cit s 2 are major allergens in orange (Citrus sinensis) fruits. *Mol Nutr Food Res*. 2006;50:282-290.

1675. Mahesh PA, et al. Prevalence of food sensitization and probable food allergy among adults in India: the EuroPrevall INCO study. *Allergy*. 2016;71(7):1010-1019.

1676. Yu HL, Cao MJ, Cai QF, et al. Effects of different processing methods on digestibility of *Scylla paramamosain* allergen (tropomyosin). *Food Chem Toxicol*. 2011;49(4):791-798.

1677. Ayuso R, Grishina G, Ibáñez MD, et al. Sarcoplasmic calcium-binding protein is an EF-hand-type protein identified as a new shrimp allergen. *J Allergy Clin Immunol*. 2009;124(1):114-120.

1678. Ayuso R, Lehrer SB, Reese G. Identification of continuous, allergenic regions of the major shrimp allergen Pen a 1 (tropomyosin). *Int Arch Allergy Immunol*. 2002;127(1):27-37.

1679. Bauermeister K, Wangorsch A, Garoffo LP, et al. Generation of a comprehensive panel of crustacean allergens from the North Sea Shrimp Crangon crangon. *Mol Immunol*. 2011;48(15-16):1983-1992.

1680. Akimoto S, Yokooji T, Ogino R, et al. Identification of allergens for food-dependent exercise-induced anaphylaxis to shrimp. *Sci Rep*. 2021;11(1):5400.

1681. Arzt L, Bokanovic D, Schrautzler C, et al. Questionable diagnostic benefit of the commercially available panel of bee venom components. *Allergy*. 2017;72(9):1419-1422.

1682. Frick M, Müller S, Bantleon F, et al. rApi m 3 and rApi m 10 improve detection of honey bee sensitization in Hymenoptera venom-allergic patients with double sensitisation to honey bee and yellow jacket venom. *Allergy*. 2015;70(12):1665-1668.

1683. Hofmann SC, Pfender N, Weckesser S, et al. Reply: to PMID 21439627. *J Allergy Clin Immunol*. 2011;128(1):248.
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How to cite this article: Dramburg S, Hilger C, Santos A, et al. EAACI Molecular Allergology User's Guide 2.0. *Pediatr Allergy Immunol.* 2023;34:e13854. doi: **10.1111/pai.13854**
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1703. Bonertz A, Mahler V, Vieths S. New Guidance on the regulation of allergen products: key aspects and outcomes. *Curr Opin Allergy Clin Immunol.* 2020;20(6):624-630.

1704. Lerouge P, Cabanes-Macheteu M, Rayon C, et al. N-Glycoprotein biosynthesis in plants: recent developments and future trends. *Plant Mol Bio.* 1998;38:31-48.

1705. Liu Z, Xia L. Identification and characterization of an arginine kinase as major allergen from silkworm larvae. *Int Arch Allergy Immunol.* 2009;150(1):8-14.

1706. Jeong KY, Han IS, Lee JY, Park KH, Lee JH, Park JW. Role of tropomyosin in silkworm allergy. *Mol Med Rep.* 2017;15(5):3264-3270.

1707. Bublin M, Dennstedt S, Buchegger M, et al. The performance of a component-based allergen microarray for the diagnosis of kiwi-fruit allergy. *Clin Exp Allergy.* 2011;41(1):129-136.

1708. Gadermaier G, Egger M, Girbl T, et al. Molecular characterization of Api g 2, a novel allergenic member of the lipid-transfer protein 1 family from celery stalks. *Mol Nutr Food Res.* 2011;55(4):568-577.

1709. Nouri HR, Sankian M, Vahedi F, et al. Diagnosis of chenopodium album allergy with a cocktail of recombinant allergens as a tool for component resolved diagnosis. *Allergy*. 2011;66:530-531.

1710. Hayek B, Vangelista L, Pastore A, et al. Molecular and immunologic characterization of a highy cross-reactive two EF-hand calcium binding alder pollen allergen Aln g 4: structural basis for calcium-modulated IgE recognition. *J Immunol.* 1998;161(1):7031-7039.

1711. Mas S, Garrido-Arandia M, Batanero E, et al. Characterization of profilin and polcalcin panallergens froom ash pollen. *J Investig Allergol Clin Immunol.* 2014;24:257-266.

1712. Pico de Coaña Y, Parody N, Fuertes MÁ. Molecular cloning and characertization of Cup a 4, a new allergen from Cupressus arizonia. *Biochem Biophys Res Commun.* 2010;401(3):451-457.

1713. Li J, Sun B, Huang Y, et al. A multicentre study assessing the prevalence of sensitisations in patients with asthma and/or rhinitis in China. *Allergy*. 2009;64(7):1083-1092.

1714. Morakabati P, Assarehzadegan MA, Khosravi GR, et al. Cloning and expression of Ama r 1, as a novel allergen of Amaranthus retroflexus pollen. *J Allergy (Cairo).* 2016;2016:4092817.

How to cite this article: Dramburg S, Hilger C, Santos A, et al. EAACI Molecular Allergology User's Guide 2.0. *Pediatr Allergy Immunol.* 2023;34:e13854. doi: **10.1111/pai.13854**