environmental intervention to reduce cockroach allergen exposure in inner-city homes. *J Allergy Clin Immunol.* 1999;103(3 Pt 1):501-506.

543. Murray CS, Poletti G, Kebadze T, et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. *Thorax.* 2006;61(5):376-382.

544. Heymann PW, Platts-Mills TA. Deciphering the importance of host and environmental factors that influence the genesis of asthma during childhood. *J Infect Dis.* 2012;206:1331-1333.

545. Zuiani C, Custovic A. Update on House Dust Mite Allergen Avoidance Measures for Asthma. *Curr Allergy Asthma Rep.* 2020;20(9):50.

546. Wilson JM, Platts-Mills TAE. Home Environmental Interventions for House Dust Mite. *J Allergy Clin Immunol Pract.* 2018;6(1):1-7.

547. Murray CS, Foden P, Sumner H, Shepley E, Custovic A, Simpson A. Preventing Severe Asthma Exacerbations in Children. A Randomized Trial of Mite-Impermeable Bedcovers. *Am J Respir Crit Care Med.* 2017;196(2):150-158.

548. Shirai T, Matsui T, Suzuki K, Chida K. Effect of pet removal on pet allergic asthma. *Chest.* 2005;127(5):1565-1571.

549. Cloutier MM, Baptist AP, Blake KV, et al. 2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. *J Allergy Clin Immunol.* 2020;146(6):1217-1270.

550. Scott M, Roberts G, Kurukulaaratchy RJ, Matthews S, Nove A, Arshad SH. Multifaceted allergen avoidance during infancy reduces asthma during childhood with the effect persisting until age 18 years. *Thorax.* 2012;67(12):1046-1051.

551. Lowe L, Murray CS, Martin L, et al. Reported versus confirmed wheeze and lung function in early life. *Arch Dis Child.* 2004;89(6):540-543.

552. Vieths S, Barber D, Chapman M, et al. Establishment of recombinant major allergens Bet v 1 and Phl p 5a as Ph. Eur. reference standards and validation of ELISA methods for their measurement. Results from feasibility studies. *Pharmeur Bio Sci Notes.* 2012;2012:118-134.

553. Zimmer J, Bridgewater J, Ferreira F, van Ree R, Rabin RL, Vieths S. The History, Present and Future of Allergen Standardization in the United States and Europe. *Front Immunol.* 2021;12:725831.

554. Houben GF, Baumert JL, Blom WM, et al. Full range of population Eliciting Dose values for 14 priority allergenic foods and recommendations for use in risk characterization. *Food Chem Toxicol.* 2020;146:111831.

555. Mills ENC, Adel-Patient K, Bernard H, et al. Detection and Quantification of Allergens in Foods and Minimum Eliciting Doses in Food-Allergic Individuals (ThRAII). *J AOAC Int.* 2019;102(5):1346-1353.

556. Stoyke M, Becker R, Brockmeyer J, et al. German Government Official Methods Board Points the Way Forward: Launch of a New Working Group for Mass Spectrometry for Protein Analysis to Detect Food Fraud and Food Allergens. *J AOAC Int.* 2019;102(5):1280-1285.

557. Gergen PJ, Mitchell HE, Calatroni A, et al. Sensitization and Exposure to Pets: The Effect on Asthma Morbidity in the US Population. *J Allergy Clin Immunol Pract.* 2018;6(1):101-107.

558. Sheehan WJ, Taylor SL, Phipatanakul W, et al. Environmental food exposure: what is the risk of clinical reactivity from cross-contact and what is the risk of sensitization. *J Allergy Clin Immunol Pract.* 2018;6:1825-1832.

559. Tuppo L, Alessandri C, Pomponi D, et al. Peamaclein-a new peach allergenic protein: similarities, differences and misleading features compared to Pru p 3. *Clin Exp Allergy.* 2013;43(1):128-140.

560. Scutt CP, Vandenbussche M. Current trends and future directions in flower development research. *Ann Bot.* 2014;114(7):1399-1406.

561. Asam C, Hofer H, Wolf M, Aglas L, Wallner M. Tree pollen allergens-an update from a molecular perspective. *Allergy.* 2015;70(10):1201-1211.

562. Movérare R, Westritschnig K, Svensson M, et al. Different IgE reactivity profiles in birch pollen-sensitive patients from six European populations revealed by recombinant allergens: an imprint of local sensitization. *Int Arch Allergy Immunol.* 2002;128(4):325-335.

563. Biedermann T, Winther L, Till SJ, Panzner P, Knulst A, Valovirta E. Birch pollen allergy in Europe. *Allergy.* 2019;74(7):1237-1248.

564. Kolek F, MDP P, Leier-Wirtz V, Friedmann A, Traidl-Hoffmann C, Damialis A. Earlier Flowering of Betula pendula Roth in Augsburg, Germany, Due to Higher Temperature, NO(2) and Urbanity, and Relationship with Betula spp. Pollen Season. *Int J Environ Res Public Health.* 2021;18(19).

565. Kirmaz C, Yuksel H, Bayrak P, Yilmaz O. Symptoms of the olive pollen allergy: do they really occur only in the pollination season? *J Investig Allergol Clin Immunol.* 2005;15(2):140-145.

566. Quiralte J, Florido F. Arias de Saavedra JM, et al. Olive allergen-specific IgE responses in patients with Olea europaea pollinosis. *Allergy.* 2002;57 Suppl 71:47-52.

567. Scala E, Abeni D, Pomponi D, et al. Ole e 1, Ole e 7, and Ole e 9: Identifying distinct clinical subsets of olive tree-allergic patients. *J Allergy Clin Immunol.* 2016;137(2):629-631.e623.

568. Scala E, Villalta D, Uasuf CG, et al. An atlas of IgE sensitization patterns in different Italian areas. A multicenter, cross-sectional study. *Eur Ann Allergy Clin Immunol.* 2018;50(5):217-225.

569. D'Amato G, Cecchi L, Bonini S, et al. Allergenic pollen and pollen allergy in Europe. *Allergy.* 2007;62(9):976-990.

570. De Linares C, Plaza MP, Valle AM, Alcázar P, Díaz de la Guardia C, Galán C. Airborne cupressaceae pollen and its major allergen, Cup a 1, in Urban Green Areas of Southern Iberian Peninsula. *Forests.* 2021;12:254. doi:10.3390/f12020254

571. Alcázar P, Cariñanos P, De Castro C, et al. Airborne plane-tree (*Platanus hispanica*) pollen distribution in the city of Córdoba, South-western Spain, and possible implications on pollen allergy. *J Investig Allergol Clin Immunol.* 2004;14(3):238-243.

572. Mansourorghabeh H, Jabbari-Azad F, Sankian M, Varasteh A, Farid-Hosseini R. The Most Common Allergenic Tree Pollen Grains in the Middle East: A Narrative Review. *Iran J Med Sci.* 2019;44(2):87-98.

573. AlKhater SA. Sensitization to Common Aeroallergens in Asthmatic Children in the Eastern Region of Saudi Arabia. *Saudi J Med Sci.* 2017;5(2):136-141.

574. Niederberger V, Pauli G, Grönlund H, et al. Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations. *J Allergy Clin Immunol.* 1998;102(4 Pt 1):579-591.

575. Gilles S, Blume C, Wimmer M, et al. Pollen exposure weakens innate defense against respiratory viruses. *Allergy.* 2020;75(3):576-587.

576. Damialis A, Gilles S, Sofiev M, et al. Higher airborne pollen concentrations correlated with increased SARS-CoV-2 infection rates, as evidenced from 31 countries across the globe. *Proc Natl Acad Sci U S A.* 2021;118(12).

577. Breiteneder H, Hassfeld W, Pettenburger K, et al. Isolation and characterization of messenger RNA from male inflorescences and pollen of the white birch (Betula verrucosa). *Int Arch Allergy Appl Immunol.* 1988;87(1):19-24.

578. Valenta R, Duchêne M, Vrtala S, et al. Profilin, a Novel Plant Pan-Allergen. *Int Arch Allergy Immunol.* 1992;99(2-4):271-273.

579. Asero R, Jimeno L, Barber D. Preliminary results of a skin prick test-based study of the prevalence and clinical impact of hypersensitivity to pollen panallergens (polcalcin and profilin). *J Investig Allergol Clin Immunol.* 2010;20(1):35-38.
580. Ciprandi G, Comite P, Mussap M, et al. Profiles of Birch Sensitization (Bet v 1, Bet v 2, and Bet v 4) and Oral Allergy Syndrome Across Italy. *J Investig Allergol Clin Immunol.* 2016;26(4):244-248.

581. Karamloo F, Schmitz N, Scheurer S, et al. Molecular cloning and characterization of a birch pollen minor allergen, Bet v 5, belonging to a family of isoflavone reductase-related proteins. *J Allergy Clin Immunol.* 1999;104(5):991-999.

582. Mahler V, Fischer S, Heiss S, Duchêne M, Kraft D, Valenta R. cDna cloning and characterization of a cross-reactive birch pollen allergen: identification as a pectin esterase. *Int Arch Allergy Immunol.* 2001;124(1-3):64-66.

583. Rodríguez R, Villalba M, Monsalve RI, Batanero E. The spectrum of olive pollen allergens. *Int Arch Allergy Immunol.* 2001;125(3):185-195.

584. Duffort O, Palomares O, Lombardero M, et al. Variability of Ole e 9 allergen in olive pollen extracts: relevance of minor allergens in immunotherapy treatments. *Int Arch Allergy Immunol.* 2006;140(2):131-138.

585. Barber D, de la Torre F, Feo F, et al. Understanding patient sensitization profiles in complex pollen areas: a molecular epidemiological study. *Allergy.* 2008;63(11):1550-1558.

586. Scala E, Abeni D, Guerra EC, et al. β-1,3-glucanase rOle e 9 and MnSOD rAsp f 6 IgE reactivity are the signature of atopic dermatitis in the Mediterranean area. *Clin Exp Allergy.* 2020;50(4):487-498.

587. Ali-Sadeghi H, Khodadadi A, Amini A, Assarehzadegan MA, Sepahi N, Zarinhadideh F. Pro j 2 is mesquite profilin: molecular characteristics and specific IgE binding activity. *Asian Pac J Allergy Immunol.* 2015;33(2):90-98.

588. Dousti F, Assarehzadegan MA, Morakabati P, Khosravi GR, Akbari B. Molecular Cloning and Expression of Pro J 1: A New Allergen of Prosopis Juliflora Pollen. *Iran J Allergy Asthma Immunol.* 2016;15(2):122-131.

589. Khosravi GR, Assarehzadegan MA, Morakabati P, Akbari B, Dousti F. Cloning and expression of Aca f 1: a new allergen of Acacia farnesiana pollen. *Cent Eur J Immunol.* 2016;41(3):273-281.

590. Di Felice G, Barletta B, Tinghino R, Pini C. Cupressaceae pollinosis: identification, purification and cloning of relevant allergens. *Int Arch Allergy Immunol.* 2001;125(4):280-289.

591. Tuppo L, Alessandri C, Giangrieco I, et al. Isolation of cypress gibberellin-regulated protein: Analysis of its structural features and IgE binding competition with homologous allergens. *Mol Immunol.* 2019;114:189-195.

592. Asero R, Abbadessa S, Aruanno A, et al. Sensitization to Gibberellin-Regulated Protein (Peamaclein) Among Italian Cypress Pollen-Sensitized Patients. *J Investig Allergol Clin Immunol.* 2021;32(1):40-47.

593. Asturias JA, Ibarrola I, Bartolomé B, Ojeda I, Malet A, Martínez A. Purification and characterization of Pla a 1, a major allergen from Platanus acerifolia pollen. *Allergy.* 2002;57(3):221-227.

594. Scala E, Cecchi L, Abeni D, et al. Pla a 2 and Pla a 3 reactivities identify plane tree-allergic patients with respiratory symptoms or food allergy. *Allergy.* 2017;72(4):671-674.

595. Danella Figo D, De Amicis K, Neiva Santos de Aquino D, et al. Cashew Tree Pollen: An Unknown Source of IgE-Reactive Molecules. *Int J Mol Sci.* 2019;20(10).

596. Victorio Puche L, Somoza ML, López-Sánchez JD, Garrido-Arandia M, Díaz-Perales A, Blanca M. Peach Tree Pollen and Prunus persica 9 Sensitisation and Allergy in Children and Adolescents. *Int Arch Allergy Immunol.* 2019;180(3):212-220.

597. D'Amato G, Spieksma FT, Liccardi G, et al. Pollen-related allergy in Europe. *Allergy.* 1998;53(6):567-578.

598. Blanca M, Victorio Puche L, Garrido-Arandia M, et al. Pru p 9, a new allergen eliciting respiratory symptoms in subjects sensitized to peach tree pollen. *PLoS One.* 2020;15(3):e0230010.

599. Scala E, Abeni D, Cecchi L, et al. Molecular Recognition Profiles and Clinical Patterns of PR-10 Sensitization in a Birch-Free Mediterranean Area. *Int Arch Allergy Immunol.* 2017;173(3):138-146.

600. Asero R. Analysis of hypersensitivity to oleaceae pollen in an olive-free and ash-free area by commercial pollen extracts and recombinant allergens. *Eur Ann Allergy Clin Immunol.* 2011;43(3):77-80.

601. Niederberger V, Purohit A, Oster JP, Spitzauer S, Valenta R, Pauli G. The allergen profile of ash (Fraxinus excelsior) pollen: cross-reactivity with allergens from various plant species. *Clin Exp Allergy.* 2002;32(6):933-941.

602. Charpin D, Calleja M, Lahoz C, Pichot C, Waisel Y. Allergy to cypress pollen. *Allergy.* 2005;60(3):293-301.

603. Scala E, Alessandri C, Bernardi ML, et al. Cross-sectional survey on immunoglobulin E reactivity in 23,077 subjects using an allergenic molecule-based microarray detection system. *Clin Exp Allergy.* 2010;40(6):911-921.

604. Agea E, Bistoni O, Russano A, et al. The biology of cypress allergy. *Allergy.* 2002;57(10):959-960.

605. Aceituno E, Del Pozo V, Mínguez A, et al. Molecular cloning of major allergen from Cupressus arizonica pollen: Cup a 1. *Clin Exp Allergy.* 2000;30(12):1750-1758.

606. Swoboda I, Grote M, Verdino P, et al. Molecular characterization of polygalacturonases as grass pollen-specific marker allergens: expansion from pollen via submicronic respirable particles. *J Immunol.* 2004;172(10):6490-6500.

607. Skypala IJ, Cecchi L, Shamji MH, Scala E, Till S. Lipid Transfer Protein allergy in the United Kingdom: Characterization and comparison with a matched Italian cohort. *Allergy.* 2019;74(7):1340-1351.

608. Kazemi-Shirazi L, Niederberger V, Linhart B, Lidholm J, Kraft D, Valenta R. Recombinant marker allergens: diagnostic gatekeepers for the treatment of allergy. *Int Arch Allergy Immunol.* 2002;127(4):259-268.

609. Scala E, Abeni D, Asero R. Disease-specific molecular profiles highlighted by radar graphic display. *Int Arch Allergy Immunol.* 2020;181:536-539.

610. Villalta D, Asero R. Analysis of the allergenic profile of patients hypersensitive to pollen pan-allergens living in two distinct areas of northern Italy. *Eur Ann Allergy Clin Immunol.* 2011;43(2):54-57.

611. Aalberse RC. Food allergens. *Environ Toxicol Pharmacol.* 1997;4(1-2):55-60.

612. Douladiris N, Savvatianos S, Roumpedaki I, Skevaki C, Mitsias D, Papadopoulos NG. A molecular diagnostic algorithm to guide pollen immunotherapy in southern Europe: towards component-resolved management of allergic diseases. *Int Arch Allergy Immunol.* 2013;162(2):163-172.

613. Asero R. Fennel, cucumber, and melon allergy successfully treated with pollen-specific injection immunotherapy. *Ann Allergy Asthma Immunol.* 2000;84(4):460-462.

614. Kinaciyan T, Jahn-Schmid B, Radakovics A, et al. Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1. *J Allergy Clin Immunol.* 2007;119(4):937-943.

615. Utsch L, Logiantara A, Wallner M, Hofer H, van Ree R, van Rijt LS. Birch pollen immunotherapy inhibits anaphylaxis to the cross-reactive apple allergen Mal d 1 in mice. *Clin Exp Allergy.* 2016;46(11):1474-1483.

616. Kleine-Tebbe J, Zuberbier T, Werfel T, et al. Is allergy immunotherapy with birch sufficient to treat patients allergic to pollen of tree species of the birch homologous group? *Allergy.* 2020;75(6):1327-1336.

617. Rodríguez R, Villalba M, Batanero E, et al. Olive pollen recombinant allergens: value in diagnosis and immunotherapy. *J Investig Allergol Clin Immunol.* 2007;17(Suppl 1):4-10.

618. Asero R, Jimeno L, Barber D. Component-resolved diagnosis of plant food allergy by SPT. *Eur Ann Allergy Clin Immunol.* 2008;40(4):115-121.
580. Ciprandi G, Comite P, Mussap M, et al. Profiles of Birch Sensitization (Bet v 1, Bet v 2, and Bet v 4) and Oral Allergy Syndrome Across Italy. *J Investig Allergol Clin Immunol.* 2016;26(4):244-248.

581. Karamloo F, Schmitz N, Scheurer S, et al. Molecular cloning and characterization of a birch pollen minor allergen, Bet v 5, belonging to a family of isoflavone reductase-related proteins. *J Allergy Clin Immunol.* 1999;104(5):991-999.

582. Mahler V, Fischer S, Heiss S, Duchêne M, Kraft D, Valenta R. cDna cloning and characterization of a cross-reactive birch pollen allergen: identification as a pectin esterase. *Int Arch Allergy Immunol.* 2001;124(1-3):64-66.

583. Rodríguez R, Villalba M, Monsalve RI, Batanero E. The spectrum of olive pollen allergens. *Int Arch Allergy Immunol.* 2001;125(3):185-195.

584. Duffort O, Palomares O, Lombardero M, et al. Variability of Ole e 9 allergen in olive pollen extracts: relevance of minor allergens in immunotherapy treatments. *Int Arch Allergy Immunol.* 2006;140(2):131-138.

585. Barber D, de la Torre F, Feo F, et al. Understanding patient sensitization profiles in complex pollen areas: a molecular epidemiological study. *Allergy.* 2008;63(11):1550-1558.

586. Scala E, Abeni D, Guerra EC, et al. β-1,3-glucanase rOle e 9 and MnSOD rAsp f 6 IgE reactivity are the signature of atopic dermatitis in the Mediterranean area. *Clin Exp Allergy.* 2020;50(4):487-498.

587. Ali-Sadeghi H, Khodadadi A, Amini A, Assarehzadegan MA, Sepahi N, Zarinhadideh F. Pro j 2 is mesquite profilin: molecular characteristics and specific IgE binding activity. *Asian Pac J Allergy Immunol.* 2015;33(2):90-98.

588. Dousti F, Assarehzadegan MA, Morakabati P, Khosravi GR, Akbari B. Molecular Cloning and Expression of Pro J 1: A New Allergen of Prosopis Juliflora Pollen. *Iran J Allergy Asthma Immunol.* 2016;15(2):122-131.

589. Khosravi GR, Assarehzadegan MA, Morakabati P, Akbari B, Dousti F. Cloning and expression of Aca f 1: a new allergen of Acacia farnesiana pollen. *Cent Eur J Immunol.* 2016;41(3):273-281.

590. Di Felice G, Barletta B, Tinghino R, Pini C. Cupressaceae pollinosis: identification, purification and cloning of relevant allergens. *Int Arch Allergy Immunol.* 2001;125(4):280-289.

591. Tuppo L, Alessandri C, Giangrieco I, et al. Isolation of cypress gibberellin-regulated protein: Analysis of its structural features and IgE binding competition with homologous allergens. *Mol Immunol.* 2019;114:189-195.

592. Asero R, Abbadessa S, Aruanno A, et al. Sensitization to Gibberellin-Regulated Protein (Peamaclein) Among Italian Cypress Pollen-Sensitized Patients. *J Investig Allergol Clin Immunol.* 2021;32(1):40-47.

593. Asturias JA, Ibarrola I, Bartolomé B, Ojeda I, Malet A, Martínez A. Purification and characterization of Pla a 1, a major allergen from Platanus acerifolia pollen. *Allergy.* 2002;57(3):221-227.

594. Scala E, Cecchi L, Abeni D, et al. Pla a 2 and Pla a 3 reactivities identify plane tree-allergic patients with respiratory symptoms or food allergy. *Allergy.* 2017;72(4):671-674.

595. Danella Figo D, De Amicis K, Neiva Santos de Aquino D, et al. Cashew Tree Pollen: An Unknown Source of IgE-Reactive Molecules. *Int J Mol Sci.* 2019;20(10).

596. Victorio Puche L, Somoza ML, López-Sánchez JD, Garrido-Arandia M, Díaz-Perales A, Blanca M. Peach Tree Pollen and Prunus persica 9 Sensitisation and Allergy in Children and Adolescents. *Int Arch Allergy Immunol.* 2019;180(3):212-220.

597. D'Amato G, Spieksma FT, Liccardi G, et al. Pollen-related allergy in Europe. *Allergy.* 1998;53(6):567-578.

598. Blanca M, Victorio Puche L, Garrido-Arandia M, et al. Pru p 9, a new allergen eliciting respiratory symptoms in subjects sensitized to peach tree pollen. *PLoS One.* 2020;15(3):e0230010.

599. Scala E, Abeni D, Cecchi L, et al. Molecular Recognition Profiles and Clinical Patterns of PR-10 Sensitization in a Birch-Free Mediterranean Area. *Int Arch Allergy Immunol.* 2017;173(3):138-146.

600. Asero R. Analysis of hypersensitivity to oleaceae pollen in an olive-free and ash-free area by commercial pollen extracts and recombinant allergens. *Eur Ann Allergy Clin Immunol.* 2011;43(3):77-80.

601. Niederberger V, Purohit A, Oster JP, Spitzauer S, Valenta R, Pauli G. The allergen profile of ash (Fraxinus excelsior) pollen: cross-reactivity with allergens from various plant species. *Clin Exp Allergy.* 2002;32(6):933-941.

602. Charpin D, Calleja M, Lahoz C, Pichot C, Waisel Y. Allergy to cypress pollen. *Allergy.* 2005;60(3):293-301.

603. Scala E, Alessandri C, Bernardi ML, et al. Cross-sectional survey on immunoglobulin E reactivity in 23,077 subjects using an allergenic molecule-based microarray detection system. *Clin Exp Allergy.* 2010;40(6):911-921.

604. Agea E, Bistoni O, Russano A, et al. The biology of cypress allergy. *Allergy.* 2002;57(10):959-960.

605. Aceituno E, Del Pozo V, Mínguez A, et al. Molecular cloning of major allergen from Cupressus arizonica pollen: Cup a 1. *Clin Exp Allergy.* 2000;30(12):1750-1758.

606. Swoboda I, Grote M, Verdino P, et al. Molecular characterization of polygalacturonases as grass pollen-specific marker allergens: expansion from pollen via submicronic respirable particles. *J Immunol.* 2004;172(10):6490-6500.

607. Skypala IJ, Cecchi L, Shamji MH, Scala E, Till S. Lipid Transfer Protein allergy in the United Kingdom: Characterization and comparison with a matched Italian cohort. *Allergy.* 2019;74(7):1340-1351.

608. Kazemi-Shirazi L, Niederberger V, Linhart B, Lidholm J, Kraft D, Valenta R. Recombinant marker allergens: diagnostic gatekeepers for the treatment of allergy. *Int Arch Allergy Immunol.* 2002;127(4):259-268.

609. Scala E, Abeni D, Asero R. Disease-specific molecular profiles highlighted by radar graphic display. *Int Arch Allergy Immunol.* 2020;181:536-539.

610. Villalta D, Asero R. Analysis of the allergenic profile of patients hypersensitive to pollen pan-allergens living in two distinct areas of northern Italy. *Eur Ann Allergy Clin Immunol.* 2011;43(2):54-57.

611. Aalberse RC. Food allergens. *Environ Toxicol Pharmacol.* 1997;4(1-2):55-60.

612. Douladiris N, Savvatianos S, Roumpedaki I, Skevaki C, Mitsias D, Papadopoulos NG. A molecular diagnostic algorithm to guide pollen immunotherapy in southern Europe: towards component-resolved management of allergic diseases. *Int Arch Allergy Immunol.* 2013;162(2):163-172.

613. Asero R. Fennel, cucumber, and melon allergy successfully treated with pollen-specific injection immunotherapy. *Ann Allergy Asthma Immunol.* 2000;84(4):460-462.

614. Kinaciyan T, Jahn-Schmid B, Radakovics A, et al. Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1. *J Allergy Clin Immunol.* 2007;119(4):937-943.

615. Utsch L, Logiantara A, Wallner M, Hofer H, van Ree R, van Rijt LS. Birch pollen immunotherapy inhibits anaphylaxis to the cross-reactive apple allergen Mal d 1 in mice. *Clin Exp Allergy.* 2016;46(11):1474-1483.

616. Kleine-Tebbe J, Zuberbier T, Werfel T, et al. Is allergy immunotherapy with birch sufficient to treat patients allergic to pollen of tree species of the birch homologous group? *Allergy.* 2020;75(6):1327-1336.

617. Rodríguez R, Villalba M, Batanero E, et al. Olive pollen recombinant allergens: value in diagnosis and immunotherapy. *J Investig Allergol Clin Immunol.* 2007;17(Suppl 1):4-10.

618. Asero R, Jimeno L, Barber D. Component-resolved diagnosis of plant food allergy by SPT. *Eur Ann Allergy Clin Immunol.* 2008;40(4):115-121.
619. Scala E, Villalta D, Meneguzzi G, Brusca I, Cecchi L. Comparison of the performance of Skin Prick and ISAC Tests in the diagnosis of allergy. *Eur Ann Allergy Clin Immunol.* 2020;52(6):258-267.

620. Malandain H, Giroux F, Cano Y. The influence of carbohydrate structures present in common allergen sources on specific IgE results. *Eur Ann Allergy Clin Immunol.* 2007;39(7):216-220.

621. Demain AL, Vaishnav P. Production of recombinant proteins by microbes and higher organisms. *Biotechnol Adv.* 2009;27(3):297-306.

622. Laffer S, Vrtala S, Duchêne M, et al. IgE-binding capacity of recombinant timothy grass (Phleum pratense) pollen allergens. *J Allergy Clin Immunol.* 1994;94(1):88-94.

623. Nolte M, Barber D, Maloney J, et al. Timothy specific IgE levels are associated with efficacy and safety of timothy grass sublingual immunotherapy tablet. *Ann Allergy Asthma Immunol.* 2015;115(6):509-515.e502.

624. Davies JM, Berman D, Beggs PJ, et al. Global Climate Change and Pollen Aeroallergens: A Southern Hemisphere Perspective. *Immunol Allergy Clin North Am.* 2021;41(1):1-16.

625. Popescu FD. Molecular biomarkers for grass pollen immunotherapy. *World J Methodol.* 2014;4:26.

626. Bousquet PJ, Chinn S, Janson C, Kogevinas M, Burney P, Jarvis D. Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European Community Respiratory Health Survey I. *Allergy.* 2007;62(3):301-309.

627. Salo PM, Arbes SJ Jr, Jaramillo R, et al. Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. *J Allergy Clin Immunol.* 2014;134(2):350-359.

628. Suphioglu C, Singh MB. Cloning, sequencing and expression in Escherichia coli of Pha a 1 and four isoforms of Pha a 5, the major allergens of canary grass pollen. *Clin Exp Allergy.* 1995;25(9):853-865.

629. Fischer S, Grote M, Fahlbusch B, Müller WD, Kraft D, Valenta R. Characterization of Phl p 4, a major timothy grass (Phleum pratense) pollen allergen. *J Allergy Clin Immunol.* 1996;98(1):189-198.

630. Devanaboyina SC, Cornelius C, Lupinek C, et al. High-resolution crystal structure and IgE recognition of the major grass pollen allergen Phl p 3. *Allergy.* 2014;69(12):1617-1628.

631. Dhammachat S, Somkid K, Piboonpocanun S, et al. Isoforms of Group 1 Allergens from a Tropical/Subtropical Para Grass (Urochloa mutica) Display Different Levels of IgE Reactivity and Cross-reactivity. *Eur Ann Allergy Clin Immunol.* 2019;51(4):174-185.

632. Somkid K, Aud-In S, Pinkaew B, Tantilipikorn P, Piboonpocanun S, Songnuan W. Manila grass (Zoysia matrella) Zoy m 1 allergen may contribute to allergic sensitization in tropical/subtropical regions due to extensive cross-reactivity with other group-1 grass pollen allergens. *Asian Pac J Allergy Immunol.* 2021.

633. Campbell BC, Gilding EK, Timbrell V, et al. Total transcriptome, proteome, and allergome of Johnson grass pollen, which is important for allergic rhinitis in subtropical regions. *J Allergy Clin Immunol.* 2015;135(1):133-142.

634. Kailaivasan TH, Timbrell VL, Solley G, et al. Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients. *Clin Transl Immunology.* 2020;9(2):e01103.

635. Davies JM, Mittag D, Dang TD, et al. Molecular cloning, expression and immunological characterisation of Pas n 1, the major allergen of Bahia grass Paspalum notatum pollen. *Mol Immunol.* 2008;46(2):286-293.

636. Timbrell VL, Riebelt L, Simmonds C, et al. An immunodiagnostic assay for quantitation of specific IgE to the major pollen allergen component, Pas n 1, of the subtropical Bahia grass. *Int Arch Allergy Immunol.* 2014;165(4):219-228.

637. Bokanovic D, Aberer W, Hemmer W, et al. Determination of sIgE to rPhl p 1 is sufficient to diagnose grass pollen allergy. *Allergy.* 2013;68(11):1403-1409.

638. Cipriani F, Tripodi S, Panetta V, et al. Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort. *Pediatr Allergy Immunol.* 2019;30(3):325-334.

639. Gadermaier E, James LK, Shamji MH, et al. Epitope specificity determines cross-protection of a SIT-induced IgG4 antibody. *Allergy.* 2016;71(1):36-46.

640. Westman M, Åberg K, Apostolovic D, et al. Sensitization to grass pollen allergen molecules in a birth cohort-natural Phl p 4 as an early indicator of grass pollen allergy. *J Allergy Clin Immunol.* 2020;145(4):1174-1181.e1176.

641. Hew M, Lee J, Varese N, et al. Epidemic thunderstorm asthma susceptibility from sensitization to ryegrass (Lolium perenne) pollen and major allergen Lol p 5. *Allergy.* 2020;75:2369-2372.

642. Thien F, Davies JM, Hew M, Douglass JA, O'Hehir RE. Thunderstorm asthma: an overview of mechanisms and management strategies. *Expert Rev Clin Immunol.* 2020;16(10):1005-1017.

643. Sutherland MF, Portelli EL, Collins AL, Rahman MA, CF MD. Patients with thunderstorm asthma or severe asthma in Melbourne: a comparison. *Med J Aust.* 2017;207:434-435.

644. Thien F, Beggs PJ, Csutoros D, et al. The Melbourne epidemic thunderstorm asthma event 2016: an investigation of environmental triggers, effect on health services, and patient risk factors. *Lancet Planet Health.* 2018;2(6):e255-e263.

645. Marks GB, Colquhoun JR, Girgis ST, et al. Thunderstorm outflows preceding epidemics of asthma during spring and summer. *Thorax.* 2001;56(6):468-471.

646. Davies JM, Thien F, Hew M. Thunderstorm asthma: controlling (deadly) grass pollen allergy. *BMJ.* 2018;360:k432.

647. Shamji MH, Kappen J, Abubakar-Waziri H, et al. Nasal allergen-neutralizing IgG(4) antibodies block IgE-mediated responses: Novel biomarker of subcutaneous grass pollen immunotherapy. *J Allergy Clin Immunol.* 2019;143(3):1067-1076.

648. Castelli S, Arasi S, Pawankar R, Matricardi PM. Collection of nasal secretions and tears and their use in allergology. *Curr Opin Allergy Clin Immunol.* 2018;18(1):1-9.

649. Castelli S, Arasi S, Tripodi S, et al. IgE antibody repertoire in nasal secretions of children and adults with seasonal allergic rhinitis: A molecular analysis. *Pediatr Allergy Immunol.* 2020;31(3):273-280.

650. Schmid JM, Würtzen PA, Dahl R, Hoffmann HJ. Pretreatment IgE sensitization patterns determine the molecular profile of the IgG4 response during updosing of subcutaneous immunotherapy with timothy grass pollen extract. *J Allergy Clin Immunol.* 2016;137(2):562-570.

651. Storkey J, Stratonovitch P, Chapman DS, Vidotto F, Semenov MA. A process-based approach to predicting the effect of climate change on the distribution of an invasive allergenic plant in Europe. *PLoS One.* 2014;9(2):e88156.

652. Stemeseder T, Hemmer W, Hawranek T, Gadermaier G. Marker allergens of weed pollen - basic considerations and diagnostic benefits in the clinical routine: Part 16 of the Series Molecular Allergology. *Allergo J Int.* 2014;23(8):274-280.

653. Anderegg WRL, Abatzoglou JT, Anderegg LDL, Bielory L, Kinney PL, Ziska L. Anthropogenic climate change is worsening North American pollen seasons. *Proc Natl Acad Sci U S A.* 2021;118(7).

654. Lake IR, Jones NR, Agnew M, et al. Climate Change and Future Pollen Allergy in Europe. *Environ Health Perspect.* 2017;125(3):385-391.

655. Fu W, Gao Z, Gao L, et al. Identification of a 62-kDa major allergen from Artemisia pollen as a putative galactose oxidase. *Allergy.* 2018;73(5):1041-1052.

656. Ariano R, Canonica GW, Passalacqua G. Possible role of climate changes in variations in pollen seasons and allergic sensitizations during 27 years. *Ann Allergy Asthma Immunol.* 2010;104(3):215-222.

657. Ghiani A, Aina R, Asero R, Bellotto E, Citterio S. Ragweed pollen collected along high-traffic roads shows a higher allergenicity than pollen sampled in vegetated areas. *Allergy.* 2012;67(7):887-894.
619. Scala E, Villalta D, Meneguzzi G, Brusca I, Cecchi L. Comparison of the performance of Skin Prick and ISAC Tests in the diagnosis of allergy. *Eur Ann Allergy Clin Immunol.* 2020;52(6):258-267.

620. Malandain H, Giroux F, Cano Y. The influence of carbohydrate structures present in common allergen sources on specific IgE results. *Eur Ann Allergy Clin Immunol.* 2007;39(7):216-220.

621. Demain AL, Vaishnav P. Production of recombinant proteins by microbes and higher organisms. *Biotechnol Adv.* 2009;27(3):297-306.

622. Laffer S, Vrtala S, Duchêne M, et al. IgE-binding capacity of recombinant timothy grass (Phleum pratense) pollen allergens. *J Allergy Clin Immunol.* 1994;94(1):88-94.

623. Nolte M, Barber D, Maloney J, et al. Timothy specific IgE levels are associated with efficacy and safety of timothy grass sublingual immunotherapy tablet. *Ann Allergy Asthma Immunol.* 2015;115(6):509-515.e502.

624. Davies JM, Berman D, Beggs PJ, et al. Global Climate Change and Pollen Aeroallergens: A Southern Hemisphere Perspective. *Immunol Allergy Clin North Am.* 2021;41(1):1-16.

625. Popescu FD. Molecular biomarkers for grass pollen immunotherapy. *World J Methodol.* 2014;4:26.

626. Bousquet PJ, Chinn S, Janson C, Kogevinas M, Burney P, Jarvis D. Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European Community Respiratory Health Survey I. *Allergy.* 2007;62(3):301-309.

627. Salo PM, Arbes SJ Jr, Jaramillo R, et al. Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. *J Allergy Clin Immunol.* 2014;134(2):350-359.

628. Suphioglu C, Singh MB. Cloning, sequencing and expression in Escherichia coli of Pha a 1 and four isoforms of Pha a 5, the major allergens of canary grass pollen. *Clin Exp Allergy.* 1995;25(9):853-865.

629. Fischer S, Grote M, Fahlbusch B, Müller WD, Kraft D, Valenta R. Characterization of Phl p 4, a major timothy grass (Phleum pratense) pollen allergen. *J Allergy Clin Immunol.* 1996;98(1):189-198.

630. Devanaboyina SC, Cornelius C, Lupinek C, et al. High-resolution crystal structure and IgE recognition of the major grass pollen allergen Phl p 3. *Allergy.* 2014;69(12):1617-1628.

631. Dhammachat S, Somkid K, Piboonpocanun S, et al. Isoforms of Group 1 Allergens from a Tropical/Subtropical Para Grass (Urochloa mutica) Display Different Levels of IgE Reactivity and Cross-reactivity. *Eur Ann Allergy Clin Immunol.* 2019;51(4):174-185.

632. Somkid K, Aud-In S, Pinkaew B, Tantilipikorn P, Piboonpocanun S, Songnuan W. Manila grass (Zoysia matrella) Zoy m 1 allergen may contribute to allergic sensitization in tropical/subtropical regions due to extensive cross-reactivity with other group-1 grass pollen allergens. *Asian Pac J Allergy Immunol.* 2021.

633. Campbell BC, Gilding EK, Timbrell V, et al. Total transcriptome, proteome, and allergome of Johnson grass pollen, which is important for allergic rhinitis in subtropical regions. *J Allergy Clin Immunol.* 2015;135(1):133-142.

634. Kailaivasan TH, Timbrell VL, Solley G, et al. Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients. *Clin Transl Immunology.* 2020;9(2):e01103.

635. Davies JM, Mittag D, Dang TD, et al. Molecular cloning, expression and immunological characterisation of Pas n 1, the major allergen of Bahia grass Paspalum notatum pollen. *Mol Immunol.* 2008;46(2):286-293.

636. Timbrell VL, Riebelt L, Simmonds C, et al. An immunodiagnostic assay for quantitation of specific IgE to the major pollen allergen component, Pas n 1, of the subtropical Bahia grass. *Int Arch Allergy Immunol.* 2014;165(4):219-228.

637. Bokanovic D, Aberer W, Hemmer W, et al. Determination of sIgE to rPhl p 1 is sufficient to diagnose grass pollen allergy. *Allergy.* 2013;68(11):1403-1409.

638. Cipriani F, Tripodi S, Panetta V, et al. Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort. *Pediatr Allergy Immunol.* 2019;30(3):325-334.

639. Gadermaier E, James LK, Shamji MH, et al. Epitope specificity determines cross-protection of a SIT-induced IgG4 antibody. *Allergy.* 2016;71(1):36-46.

640. Westman M, Åberg K, Apostolovic D, et al. Sensitization to grass pollen allergen molecules in a birth cohort-natural Phl p 4 as an early indicator of grass pollen allergy. *J Allergy Clin Immunol.* 2020;145(4):1174-1181.e1176.

641. Hew M, Lee J, Varese N, et al. Epidemic thunderstorm asthma susceptibility from sensitization to ryegrass (Lolium perenne) pollen and major allergen Lol p 5. *Allergy.* 2020;75:2369-2372.

642. Thien F, Davies JM, Hew M, Douglass JA, O'Hehir RE. Thunderstorm asthma: an overview of mechanisms and management strategies. *Expert Rev Clin Immunol.* 2020;16(10):1005-1017.

643. Sutherland MF, Portelli EL, Collins AL, Rahman MA, CF MD. Patients with thunderstorm asthma or severe asthma in Melbourne: a comparison. *Med J Aust.* 2017;207:434-435.

644. Thien F, Beggs PJ, Csutoros D, et al. The Melbourne epidemic thunderstorm asthma event 2016: an investigation of environmental triggers, effect on health services, and patient risk factors. *Lancet Planet Health.* 2018;2(6):e255-e263.

645. Marks GB, Colquhoun JR, Girgis ST, et al. Thunderstorm outflows preceding epidemics of asthma during spring and summer. *Thorax.* 2001;56(6):468-471.

646. Davies JM, Thien F, Hew M. Thunderstorm asthma: controlling (deadly) grass pollen allergy. *BMJ.* 2018;360:k432.

647. Shamji MH, Kappen J, Abubakar-Waziri H, et al. Nasal allergen-neutralizing IgG(4) antibodies block IgE-mediated responses: Novel biomarker of subcutaneous grass pollen immunotherapy. *J Allergy Clin Immunol.* 2019;143(3):1067-1076.

648. Castelli S, Arasi S, Pawankar R, Matricardi PM. Collection of nasal secretions and tears and their use in allergology. *Curr Opin Allergy Clin Immunol.* 2018;18(1):1-9.

649. Castelli S, Arasi S, Tripodi S, et al. IgE antibody repertoire in nasal secretions of children and adults with seasonal allergic rhinitis: A molecular analysis. *Pediatr Allergy Immunol.* 2020;31(3):273-280.

650. Schmid JM, Würtzen PA, Dahl R, Hoffmann HJ. Pretreatment IgE sensitization patterns determine the molecular profile of the IgG4 response during updosing of subcutaneous immunotherapy with timothy grass pollen extract. *J Allergy Clin Immunol.* 2016;137(2):562-570.

651. Storkey J, Stratonovitch P, Chapman DS, Vidotto F, Semenov MA. A process-based approach to predicting the effect of climate change on the distribution of an invasive allergenic plant in Europe. *PLoS One.* 2014;9(2):e88156.

652. Stemeseder T, Hemmer W, Hawranek T, Gadermaier G. Marker allergens of weed pollen - basic considerations and diagnostic benefits in the clinical routine: Part 16 of the Series Molecular Allergology. *Allergo J Int.* 2014;23(8):274-280.

653. Anderegg WRL, Abatzoglou JT, Anderegg LDL, Bielory L, Kinney PL, Ziska L. Anthropogenic climate change is worsening North American pollen seasons. *Proc Natl Acad Sci U S A.* 2021;118(7).

654. Lake IR, Jones NR, Agnew M, et al. Climate Change and Future Pollen Allergy in Europe. *Environ Health Perspect.* 2017;125(3):385-391.

655. Fu W, Gao Z, Gao L, et al. Identification of a 62-kDa major allergen from Artemisia pollen as a putative galactose oxidase. *Allergy.* 2018;73(5):1041-1052.

656. Ariano R, Canonica GW, Passalacqua G. Possible role of climate changes in variations in pollen seasons and allergic sensitizations during 27 years. *Ann Allergy Asthma Immunol.* 2010;104(3):215-222.

657. Ghiani A, Aina R, Asero R, Bellotto E, Citterio S. Ragweed pollen collected along high-traffic roads shows a higher allergenicity than pollen sampled in vegetated areas. *Allergy.* 2012;67(7):887-894.
658a. Bouley J, Groeme R, Le Mignon M, et al. Identification of the cysteine protease Amb a 11 as a novel major allergen from short ragweed. *J Allergy Clin Immunol.* 2015;136(4):1055-1064.

658b. Arbes SJ Jr, Gergen PJ, Elliott L, et al. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. *J Allergy Clin Immunol.* 2005;116(2):377-383.

658c. Burbach GJ, Heinzerling LM, Edenharter G, et al. GA(2)LEN skin test study II: clinical relevance Molecular Allergology User's Guide 2.0 212 of inhalant allergen sensitisations in Europe. *Allergy*. 2009;64(10):1507-1515.

659a. Forkel S, Beutner C, Heetfeld A, et al. Allergic Rhinitis to Weed Pollen in Germany: Dominance by Plantain, Rising Prevalence, and Polysensitization Rates over 20 Years. *Int Arch Allergy Immunol.* 2020;181(2):128-135.

659b. Ruëff F, Przybilla B, Walker A, et al. Sensitisation to common ragweed in southern Bavaria: clinical and geographical risk factors in atopic patients. *Int Arch Allergy Immunol.* 2012;159(1):65-74.

660. Minami T, Fukutomi Y, Inada R, et al. Regional differences in the prevalence of sensitization to environmental allergens: Analysis on IgE antibody testing conducted at major clinical testing laboratories throughout Japan from 2002 to 2011. *Allergol Int.* 2019;68(4):440-449.

661. Bass DJ, Delpech V, Beard J, Bass P, Walls RS. Late summer and fall (March-May) pollen allergy and respiratory disease in Northern New South Wales. *Australia Ann Allergy Asthma Immunol.* 2000;85(5):374-381.

662. Bordas-Le Floch V, Le Mignon M, Bouley J, et al. Identification of Novel Short Ragweed Pollen Allergens Using Combined Transcriptomic and Immunoproteomic Approaches. *PLoS One.* 2015;10(8):e0136258.

663. Wang W, Zhang XH, Zhu L, Liu YX. Investigation of Allergic Sensitization Pattern in 4,203 Children in Northern China. *Int Arch Allergy Immunol.* 2021;182(5):455-458.

664. Hao GD, Zheng YW, Gjesing B, et al. Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China. *J Zhejiang Univ Sci B.* 2013;14(3):240-246.

665. Sung M, Kim SW, Kim JH, Lim DH. Regional Difference of Causative Pollen in Children with Allergic Rhinitis. *J Korean Med Sci.* 2017;32(6):926-932.

666. Stemeseder T, Klinglmayr E, Moser S, et al. Cross-sectional study on allergic sensitization of Austrian adolescents using molecule-based IgE profiling. *Allergy*. 2017;72(5):754-763.

667. Barber D, Diaz-Perales A, Villalba M, Chivato T. Challenges for allergy diagnosis in regions with complex pollen exposures. *Curr Allergy Asthma Rep.* 2015;15(2):496.

668. Pablos I, Egger M, Vejyar E, et al. Similar Allergenicity to Different Artemisia Species Is a Consequence of Highly Cross-Reactive Art v 1-Like Molecules. *Medicina (Kaunas).* 2019;55(8).

669. Gao ZS, Yang ZW, Wu SD, et al. Peach allergy in China: a dominant role for mugwort pollen LTP as primary sensitizer. *J Allergy Clin Immunol.* 2013;Jan:131(131):224-136.

670. Zhao L, Fu W, Gao B, et al. Variation in IgE binding potencies of seven Artemisia species depending on content of major allergens. *Clin Transl Allergy.* 2020;10(1):50.

671. Atis S, Tutluoglu B, Sahin K, Yaman M, Kucukusta AR, Oktay I. Sensitization to sunflower pollen and lung functions in sunflower processing workers. *Allergy.* 2002;57(1):35-39.

672. Ghosh N, Sircar G, Saha B, Pandey N, Gupta Bhattacharya S. Search for Allergens from the Pollen Proteome of Sunflower (Helianthus annuus L.): A Major Sensitizer for Respiratory Allergy Patients. *PLoS One.* 2015;10(9):e0138992.

673. Gruber P, Gadermaier G, Bauer R, et al. Role of the polypeptide backbone and post-translational modifications in cross-reactivity

of Art v 1, the major mugwort pollen allergen. *Biol Chem.* 2009;390(5-6):445-451.

674. Kumar S, Khandpu S, Rao DN, Wahaab S, Khanna N. Immunological response to Parthenium hysterophorus in Indian Patients with Parthenium sensitive atopic dermatitis. *Immunol Invest.* 2012;41(1):75-86.

675. Pablos I, Eichhorn S, Briza P, et al. Proteomic profiling of the weed feverfew, a neglected pollen allergen source. *Sci Rep.* 2017;7(1):6049.

676. Liccardi G, Baldi G, Berra A, et al. Allergy in urban elderly population living in Campania region (Southern Italy). A multicenter study. *Eur Ann Allergy Clin Immunol.* 2016;48(4):156-160.

677. Liccardi G, Calzetta L, Apicella G, et al. Allergy in adolescent population (14-18 years) living in Campania region (Southern Italy). A multicenter study. *Eur Ann Allergy Clin Immunol.* 2019;51(1).

678. Gadermaier G, Eichhorn S, Vejyar E, et al. Plantago lanceolata: an important trigger of summer pollinosis with limited IgE cross-reactivity. *J Allergy Clin Immunol.* 2014;134(2):472-475.

679. Stemeseder T, Metz-Favre C, de Blav F, Pauli G, Gadermaier G. Do Plantago lanceolata Skin Prick Test-Positive Patients Display IgE to Genuine Plantain Pollen Allergens? Investigation of Pollen Allergic Patients from the North-East of France. *Int Arch Allergy Immunol.* 2018;177(2):97-106.

680. Gadermaier G, Hauser M, Ferreira F. Allergens of weed pollen: an overview on recombinant and natural molecules. *Methods.* 2014;66(1):55-66.

681. Villalba M, Barderas R, Mas S, Colas C, Batanero E, Rodriguez R. Amaranthaceae pollens: review of an emerging allergy in the mediterranean area. *J Investig Allergol Clin Immunol.* 2014;24(6):371-381. quiz 372 p preceding 382.

682. Assarehzadegan MA, Amini A, Sankian M, Tehrani M, Jabbari F, Varasteh A. Sal k 4, a new allergen of Salsola kali, is profilin: a predictive value of conserved conformational regions in cross-reactivity with other plant-derived profilins. *Biosci Biotechnol Biochem.* 2010;74(7):1441-1446.

683. Assarehzadegan MA, Sankian M, Jabbari F, Tehrani M, Falak R, Varasteh A. Identification of methionine synthase (Sal k 3), as a novel allergen of Salsola kali pollen. *Mol Biol Rep.* 2011;38(1):65-73.

684. Castro L, Mas S, Barderas R, et al. Sal k 5, a member of the widespread Ole e 1-like protein family, is a new allergen of Russian thistle (Salsola kali) pollen. *Int Arch Allergy Immunol.* 2014;163(2):142-153.

685. Mas S, Oeo-Santos C, Cuesta-Herranz J, et al. A relevant IgE-reactive 28kDa protein identified from Salsola kali pollen extract by proteomics a natural degradation product of an integral 47kDa polygalaturonase. *Biochim Biophys Acta Proteins Proteomics.* 2017;1865(8):1067-1076.

686. Asero R, Bellotto E, Ghiani A, Aina R, Villalta D, Citterio S. Concomitant sensitization to ragweed and mugwort pollen: who is who in clinical allergy? *Ann Allergy Asthma Immunol.* 2014;113(3):307-313.

687. Jahn-Schmid B, Hauser M, Wopfner N, et al. Humoral and cellular cross-reactivity between Amb a 1, the major ragweed pollen allergen, and its mugwort homolog Art v 6. *J Immunol.* 2012;188(3):1559-1567.

688. Pablos I, Eichhorn S, Machado Y, et al. Distinct epitope structures of defensin-like proteins linked to proline-rich regions give rise to differences in their allergenic activity. *Allergy.* 2018;73(2):431-441.

689. Wangorsch A, Lidholm J, Mattsson LA, et al. Identification of a defensin as novel allergen in celery root: Api g 7 as a missing link in the diagnosis of celery allergy? *Allergy.* 2021.

690. Egger M, Mutschlechner S, Wopfner N, Gadermaier G, Briza P, Ferreira F. Pollen-food syndromes associated with weed pollinosis: an update from the molecular point of view. *Allergy.* 2006;61(4):461-476.
658a. Bouley J, Groeme R, Le Mignon M, et al. Identification of the cysteine protease Amb a 11 as a novel major allergen from short ragweed. *J Allergy Clin Immunol.* 2015;136(4):1055-1064.

658b. Arbes SJ Jr, Gergen PJ, Elliott L, et al. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. *J Allergy Clin Immunol.* 2005;116(2):377-383.

658c. Burbach GJ, Heinzerling LM, Edenharter G, et al. GA(2)LEN skin test study II: clinical relevance Molecular Allergology User's Guide 2.0 212 of inhalant allergen sensitisations in Europe. *Allergy*. 2009;64(10):1507-1515.

659a. Forkel S, Beutner C, Heetfeld A, et al. Allergic Rhinitis to Weed Pollen in Germany: Dominance by Plantain, Rising Prevalence, and Polysensitization Rates over 20 Years. *Int Arch Allergy Immunol.* 2020;181(2):128-135.

659b. Ruëff F, Przybilla B, Walker A, et al. Sensitisation to common ragweed in southern Bavaria: clinical and geographical risk factors in atopic patients. *Int Arch Allergy Immunol.* 2012;159(1):65-74.

660. Minami T, Fukutomi Y, Inada R, et al. Regional differences in the prevalence of sensitization to environmental allergens: Analysis on IgE antibody testing conducted at major clinical testing laboratories throughout Japan from 2002 to 2011. *Allergol Int.* 2019;68(4):440-449.

661. Bass DJ, Delpech V, Beard J, Bass P, Walls RS. Late summer and fall (March-May) pollen allergy and respiratory disease in Northern New South Wales. *Australia Ann Allergy Asthma Immunol.* 2000;85(5):374-381.

662. Bordas-Le Floch V, Le Mignon M, Bouley J, et al. Identification of Novel Short Ragweed Pollen Allergens Using Combined Transcriptomic and Immunoproteomic Approaches. *PLoS One.* 2015;10(8):e0136258.

663. Wang W, Zhang XH, Zhu L, Liu YX. Investigation of Allergic Sensitization Pattern in 4,203 Children in Northern China. *Int Arch Allergy Immunol.* 2021;182(5):455-458.

664. Hao GD, Zheng YW, Gjesing B, et al. Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China. *J Zhejiang Univ Sci B.* 2013;14(3):240-246.

665. Sung M, Kim SW, Kim JH, Lim DH. Regional Difference of Causative Pollen in Children with Allergic Rhinitis. *J Korean Med Sci.* 2017;32(6):926-932.

666. Stemeseder T, Klinglmayr E, Moser S, et al. Cross-sectional study on allergic sensitization of Austrian adolescents using molecule-based IgE profiling. *Allergy*. 2017;72(5):754-763.

667. Barber D, Diaz-Perales A, Villalba M, Chivato T. Challenges for allergy diagnosis in regions with complex pollen exposures. *Curr Allergy Asthma Rep.* 2015;15(2):496.

668. Pablos I, Egger M, Vejyar E, et al. Similar Allergenicity to Different Artemisia Species Is a Consequence of Highly Cross-Reactive Art v 1-Like Molecules. *Medicina (Kaunas).* 2019;55(8).

669. Gao ZS, Yang ZW, Wu SD, et al. Peach allergy in China: a dominant role for mugwort pollen LTP as primary sensitizer. *J Allergy Clin Immunol.* 2013;Jan:131(131):224-136.

670. Zhao L, Fu W, Gao B, et al. Variation in IgE binding potencies of seven Artemisia species depending on content of major allergens. *Clin Transl Allergy.* 2020;10(1):50.

671. Atis S, Tutluoglu B, Sahin K, Yaman M, Kucukusta AR, Oktay I. Sensitization to sunflower pollen and lung functions in sunflower processing workers. *Allergy.* 2002;57(1):35-39.

672. Ghosh N, Sircar G, Saha B, Pandey N, Gupta Bhattacharya S. Search for Allergens from the Pollen Proteome of Sunflower (Helianthus annuus L.): A Major Sensitizer for Respiratory Allergy Patients. *PLoS One.* 2015;10(9):e0138992.

673. Gruber P, Gadermaier G, Bauer R, et al. Role of the polypeptide backbone and post-translational modifications in cross-reactivity

of Art v 1, the major mugwort pollen allergen. *Biol Chem.* 2009;390(5-6):445-451.

674. Kumar S, Khandpu S, Rao DN, Wahaab S, Khanna N. Immunological response to Parthenium hysterophorus in Indian Patients with Parthenium sensitive atopic dermatitis. *Immunol Invest.* 2012;41(1):75-86.

675. Pablos I, Eichhorn S, Briza P, et al. Proteomic profiling of the weed feverfew, a neglected pollen allergen source. *Sci Rep.* 2017;7(1):6049.

676. Liccardi G, Baldi G, Berra A, et al. Allergy in urban elderly population living in Campania region (Southern Italy). A multicenter study. *Eur Ann Allergy Clin Immunol.* 2016;48(4):156-160.

677. Liccardi G, Calzetta L, Apicella G, et al. Allergy in adolescent population (14-18 years) living in Campania region (Southern Italy). A multicenter study. *Eur Ann Allergy Clin Immunol.* 2019;51(1).

678. Gadermaier G, Eichhorn S, Vejyar E, et al. Plantago lanceolata: an important trigger of summer pollinosis with limited IgE cross-reactivity. *J Allergy Clin Immunol.* 2014;134(2):472-475.

679. Stemeseder T, Metz-Favre C, de Blav F, Pauli G, Gadermaier G. Do Plantago lanceolata Skin Prick Test-Positive Patients Display IgE to Genuine Plantain Pollen Allergens? Investigation of Pollen Allergic Patients from the North-East of France. *Int Arch Allergy Immunol.* 2018;177(2):97-106.

680. Gadermaier G, Hauser M, Ferreira F. Allergens of weed pollen: an overview on recombinant and natural molecules. *Methods.* 2014;66(1):55-66.

681. Villalba M, Barderas R, Mas S, Colas C, Batanero E, Rodriguez R. Amaranthaceae pollens: review of an emerging allergy in the mediterranean area. *J Investig Allergol Clin Immunol.* 2014;24(6):371-381. quiz 372 p preceding 382.

682. Assarehzadegan MA, Amini A, Sankian M, Tehrani M, Jabbari F, Varasteh A. Sal k 4, a new allergen of Salsola kali, is profilin: a predictive value of conserved conformational regions in cross-reactivity with other plant-derived profilins. *Biosci Biotechnol Biochem.* 2010;74(7):1441-1446.

683. Assarehzadegan MA, Sankian M, Jabbari F, Tehrani M, Falak R, Varasteh A. Identification of methionine synthase (Sal k 3), as a novel allergen of Salsola kali pollen. *Mol Biol Rep.* 2011;38(1):65-73.

684. Castro L, Mas S, Barderas R, et al. Sal k 5, a member of the widespread Ole e 1-like protein family, is a new allergen of Russian thistle (Salsola kali) pollen. *Int Arch Allergy Immunol.* 2014;163(2):142-153.

685. Mas S, Oeo-Santos C, Cuesta-Herranz J, et al. A relevant IgE-reactive 28kDa protein identified from Salsola kali pollen extract by proteomics a natural degradation product of an integral 47kDa polygalaturonase. *Biochim Biophys Acta Proteins Proteomics.* 2017;1865(8):1067-1076.

686. Asero R, Bellotto E, Ghiani A, Aina R, Villalta D, Citterio S. Concomitant sensitization to ragweed and mugwort pollen: who is who in clinical allergy? *Ann Allergy Asthma Immunol.* 2014;113(3):307-313.

687. Jahn-Schmid B, Hauser M, Wopfner N, et al. Humoral and cellular cross-reactivity between Amb a 1, the major ragweed pollen allergen, and its mugwort homolog Art v 6. *J Immunol.* 2012;188(3):1559-1567.

688. Pablos I, Eichhorn S, Machado Y, et al. Distinct epitope structures of defensin-like proteins linked to proline-rich regions give rise to differences in their allergenic activity. *Allergy.* 2018;73(2):431-441.

689. Wangorsch A, Lidholm J, Mattsson LA, et al. Identification of a defensin as novel allergen in celery root: Api g 7 as a missing link in the diagnosis of celery allergy? *Allergy.* 2021.

690. Egger M, Mutschlechner S, Wopfner N, Gadermaier G, Briza P, Ferreira F. Pollen-food syndromes associated with weed pollinosis: an update from the molecular point of view. *Allergy.* 2006;61(4):461-476.
691. Tordesillas L, Sirvent S, Diaz-Perales A, et al. Plant lipid transfer protein allergens: no cross-reactivity between those from foods and olive and Parietaria pollen. *Int Arch Allergy Immunol.* 2011;156(3):291-296.

692. Gao Z, Fu WY, Sun Y, et al. Artemisia pollen allergy in China: Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization. *Allergy.* 2019;74(2):284-293.

693. Rodriguez Del Rio P, Diaz-Perales A, Sanchez-Garcia S, et al. Profilin, a Change in the Paradigm. *J Investig Allergol Clin Immunol.* 2018;28(1):1-12.

694. Asero R, Monsalve R, Barber D. Profilin sensitization detected in the office by skin prick test: a study of prevalence and clinical relevance of profilin as a plant food allergen. *Clin Exp Allergy.* 2008;38(6):1033-1037.

695. Kratzer B, Kohler C, Hofer S, et al. Prevention of allergy by virus-like nanoparticles (VNP) delivering shielded versions of major allergens in a humanized murine allergy model. *Allergy.* 2019;74(2):246-260.

696. Di Muzio M, Wildner S, Huber S, et al. Hydrogen/deuterium exchange memory NMR reveals structural epitopes involved in IgE cross-reactivity of allergenic lipid transfer proteins. *J Biol Chem.* 2020;295(51):17398-17410.

697. de Blay F, Heymann PW, Chapman MD, Platts-Mills TA. Airborne dust mite allergens: comparison of group II allergens with group I mite allergen and cat-allergen Fel d I. *J Allergy Clin Immunol.* 1991;88(6):919-926.

698. Tovey ER, Chapman MD, Platts-Mills TA. Mite faeces are a major source of house dust allergens. *Nature.* 1981;289(5798):592-593.

699. Tovey ER, Chapman MD, Wells CW, Platts-Mills TA. The distribution of dust mite allergen in the houses of patients with asthma. *Am Rev Respir Dis.* 1981;124(5):630-635.

700. Darquenne C. Aerosol deposition in health and disease. *J Aerosol Med Pulm Drug Deliv.* 2012;25(3):140-147.

701. Caraballo L, Puerta L, Martínez B, Moreno L. Identification of allergens from the mite Blomia tropicalis. *Clin Exp Allergy.* 1994;24(11):1056-1060.

702. Arruda LK, Fernandez-Caldas E, Naspitz CK, Montealegre F, Vailes LD, Chapman MD. Identification of Blomia tropicalis allergen Blo t 5 by cDNA cloning. *Int Arch Allergy Immunol.* 1995;107(1-3):456-457.

703. Heymann PW, Chapman MD, Aalberse RC, Fox JW, Platts-Mills TA. Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp). *J Allergy Clin Immunol.* 1989;83(6):1055-1067.

704. Derewenda U, Li J, Derewenda Z, et al. The crystal structure of a major dust mite allergen Der p 2, and its biological implications. *J Mol Biol.* 2002;318(1):189-197.

705. de Halleux S, Stura E, VanderElst L, Carlier V, Jacquemin M, Saint-Remy JM. Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen. *J Allergy Clin Immunol.* 2006;117(3):571-576.

706. Mueller GA, Edwards LL, Aloor JJ, et al. The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins. *J Allergy Clin Immunol.* 2010;125(4):909-917.e904.

707. Mueller GA, Gosavi RA, Krahn JM, et al. Der p 5 crystal structure provides insight into the group 5 dust mite allergens. *J Biol Chem.* 2010;285(33):25394-25401.

708. Mueller GA, Pedersen LC, Glesner J, et al. Analysis of glutathione S-transferase allergen cross-reactivity in a North American population: Relevance for molecular diagnosis. *J Allergy Clin Immunol.* 2015;136(5):1369-1377.

709. Waldron R, McGowan J, Gordon N, McCarthy C, Mitchell EB, Fitzpatrick DA. Proteome and allergenome of the European house dust mite Dermatophagoides pteronyssinus. *PLoS One.* 2019;14(5):e0216171.

710. Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. *N Engl J Med.* 1990;323(8):502-507.

711. Resch Y, Michel S, Kabesch M, Lupinek C, Valenta R, Vrtala S. Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children. *J Allergy Clin Immunol.* 2015;136(4):1083-1091.

712. Muddaluru V, Valenta R, Vrtala S, et al. Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA. *Allergy.* 2021;76(7):2177-2188.

713. Batard T, Baron-Bodo V, Martelet A, et al. Patterns of IgE sensitization in house dust mite-allergic patients: implications for allergen immunotherapy. *Allergy.* 2016;71(2):220-229.

714. Pinheiro CS, Silva ES, de Andrade Belitardo EMM, et al. En route to personalized medicine: uncovering distinct IgE reactivity pattern to house dust mite components in Brazilian and Austrian allergic patients. *Clin Transl Allergy.* 2021;11:e12004.

715. Carvalho Kdos A, de Melo-Neto OP, Magalhães FB, et al. Blomia tropicalis Blo t 5 and Blo t 21 recombinant allergens might confer higher specificity to serodiagnostic assays than whole mite extract. *BMC Immunol.* 2013;14:11.

716. Platts-Mills TA, Tovey ER, Mitchell EB, Moszoro H, Nock P, Wilkins SR. Reduction of bronchial hyperreactivity during prolonged allergen avoidance. *Lancet.* 1982;2(8300):675-678.

717. Huang HJ, Resch-Marat Y, Casset A, et al. IgE recognition of the house dust mite allergen Der p 37 is associated with asthma. *J Allergy Clin Immunol.* 2022;149(3):1031-1043.

718. Abu Khweek A, Kim E, Joldrichsen MR, Amer AO, Boyaka PN. Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma. *Front Immunol.* 2020;11:534501.

719. Wan H, Winton HL, Soeller C, et al. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. *J Clin Invest.* 1999;104(1):123-133.

720. Zhang J, Chen J, Robinson C. Cellular and Molecular Events in the Airway Epithelium Defining the Interaction Between House Dust Mite Group 1 Allergens and Innate Defences. *Int J Mol Sci.* 2018;19(11).

721. Schulz O, Sewell HF, Shakib F. Proteolytic cleavage of CD25, the alpha subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity. *J Exp Med.* 1998;187(2):271-275.

722. Chevigné A, Jacquet A. Emerging roles of the protease allergen Der p 1 in house dust mite-induced airway inflammation. *J Allergy Clin Immunol.* 2018;142(2):398-400.

723. Hewitt CR, Brown AP, Hart BJ, Pritchard DI. A major house dust mite allergen disrupts the immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases. *J Exp Med.* 1995;182(5):1537-1544.

724. Serhan N, Basso L, Sibilano R, et al. House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation. *Nat Immunol.* 2019;20(11):1435-1443.

725. Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. *Nat Med.* 2009;15(4):410-416.

726. Pulsawat P, Theeraapisakkun M, Nony E, et al. Characterization of the house dust mite allergen Der p 21 produced in Pichia pastoris. *Protein Expr Purif.* 2014;101:8-13.

727. Soongrung T, Mongkorntanyatip K, Peepim T, et al. The Blomia tropicalis allergen Blo t 7 stimulates innate immune signalling pathways through TLR2. *Clin Exp Allergy.* 2018;48(4):464-474.

728. Pulsawat P, Soongrung T, Satitsuksanoa P, et al. The house dust mite allergen Der p 5 binds lipid ligands and stimulates airway epithelial cells through a TLR2-dependent pathway. *Clin Exp Allergy.* 2019;49(3):378-390.
691. Tordesillas L, Sirvent S, Diaz-Perales A, et al. Plant lipid transfer protein allergens: no cross-reactivity between those from foods and olive and Parietaria pollen. *Int Arch Allergy Immunol.* 2011;156(3):291-296.

692. Gao Z, Fu WY, Sun Y, et al. Artemisia pollen allergy in China: Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization. *Allergy*. 2019;74(2):284-293.

693. Rodriguez Del Rio P, Diaz-Perales A, Sanchez-Garcia S, et al. Profilin, a Change in the Paradigm. *J Investig Allergol Clin Immunol.* 2018;28(1):1-12.

694. Asero R, Monsalve R, Barber D. Profilin sensitization detected in the office by skin prick test: a study of prevalence and clinical relevance of profilin as a plant food allergen. *Clin Exp Allergy.* 2008;38(6):1033-1037.

695. Kratzer B, Kohler C, Hofer S, et al. Prevention of allergy by virus-like nanoparticles (VNP) delivering shielded versions of major allergens in a humanized murine allergy model. *Allergy*. 2019;74(2):246-260.

696. Di Muzio M, Wildner S, Huber S, et al. Hydrogen/deuterium exchange memory NMR reveals structural epitopes involved in IgE cross-reactivity of allergenic lipid transfer proteins. *J Biol Chem.* 2020;295(51):17398-17410.

697. de Blay F, Heymann PW, Chapman MD, Platts-Mills TA. Airborne dust mite allergens: comparison of group II allergens with group I mite allergen and cat-allergen Fel d I. *J Allergy Clin Immunol.* 1991;88(6):919-926.

698. Tovey ER, Chapman MD, Platts-Mills TA. Mite faeces are a major source of house dust allergens. *Nature*. 1981;289(5798):592-593.

699. Tovey ER, Chapman MD, Wells CW, Platts-Mills TA. The distribution of dust mite allergen in the houses of patients with asthma. *Am Rev Respir Dis.* 1981;124(5):630-635.

700. Darquenne C. Aerosol deposition in health and disease. *J Aerosol Med Pulm Drug Deliv.* 2012;25(3):140-147.

701. Caraballo L, Puerta L, Martínez B, Moreno L. Identification of allergens from the mite Blomia tropicalis. *Clin Exp Allergy.* 1994;24(11):1056-1060.

702. Arruda LK, Fernandez-Caldas E, Naspitz CK, Montealegre F, Vailes LD, Chapman MD. Identification of Blomia tropicalis allergen Blo t 5 by cDNA cloning. *Int Arch Allergy Immunol.* 1995;107(1-3):456-457.

703. Heymann PW, Chapman MD, Aalberse RC, Fox JW, Platts-Mills TA. Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp). *J Allergy Clin Immunol.* 1989;83(6):1055-1067.

704. Derewenda U, Li J, Derewenda Z, et al. The crystal structure of a major dust mite allergen Der p 2, and its biological implications. *J Mol Biol.* 2002;318(1):189-197.

705. de Halleux S, Stura E, VanderElst L, Carlier V, Jacquemin M, Saint-Remy JM. Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen. *J Allergy Clin Immunol.* 2006;117(3):571-576.

706. Mueller GA, Edwards LL, Aloor JJ, et al. The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins. *J Allergy Clin Immunol.* 2010;125(4):909-917.e904.

707. Mueller GA, Gosavi RA, Krahn JM, et al. Der p 5 crystal structure provides insight into the group 5 dust mite allergens. *J Biol Chem.* 2010;285(33):25394-25401.

708. Mueller GA, Pedersen LC, Glesner J, et al. Analysis of glutathione S-transferase allergen cross-reactivity in a North American population: Relevance for molecular diagnosis. *J Allergy Clin Immunol.* 2015;136(5):1369-1377.

709. Waldron R, McGowan J, Gordon N, McCarthy C, Mitchell EB, Fitzpatrick DA. Proteome and allergenome of the European house dust mite Dermatophagoides pteronyssinus. *PLoS One.* 2019;14(5):e0216171.

710. Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. *N Engl J Med.* 1990;323(8):502-507.

711. Resch Y, Michel S, Kabesch M, Lupinek C, Valenta R, Vrtala S. Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children. *J Allergy Clin Immunol.* 2015;136(4):1083-1091.

712. Muddaluru V, Valenta R, Vrtala S, et al. Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA. *Allergy*. 2021;76(7):2177-2188.

713. Batard T, Baron-Bodo V, Martelet A, et al. Patterns of IgE sensitization in house dust mite-allergic patients: implications for allergen immunotherapy. *Allergy*. 2016;71(2):220-229.

714. Pinheiro CS, Silva ES, de Andrade Belitardo EMM, et al. En route to personalized medicine: uncovering distinct IgE reactivity pattern to house dust mite components in Brazilian and Austrian allergic patients. *Clin Transl Allergy*. 2021;11:e12004.

715. Carvalho Kdos A, de Melo-Neto OP, Magalhães FB, et al. Blomia tropicalis Blo t 5 and Blo t 21 recombinant allergens might confer higher specificity to serodiagnostic assays than whole mite extract. *BMC Immunol.* 2013;14:11.

716. Platts-Mills TA, Tovey ER, Mitchell EB, Moszoro H, Nock P, Wilkins SR. Reduction of bronchial hyperreactivity during prolonged allergen avoidance. *Lancet*. 1982;2(8300):675-678.

717. Huang HJ, Resch-Marat Y, Casset A, et al. IgE recognition of the house dust mite allergen Der p 37 is associated with asthma. *J Allergy Clin Immunol.* 2022;149(3):1031-1043.

718. Abu Khweek A, Kim E, Joldrichsen MR, Amer AO, Boyaka PN. Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma. *Front Immunol.* 2020;11:534501.

719. Wan H, Winton HL, Soeller C, et al. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. *J Clin Invest.* 1999;104(1):123-133.

720. Zhang J, Chen J, Robinson C. Cellular and Molecular Events in the Airway Epithelium Defining the Interaction Between House Dust Mite Group 1 Allergens and Innate Defences. *Int J Mol Sci.* 2018;19(11).

721. Schulz O, Sewell HF, Shakib F. Proteolytic cleavage of CD25, the alpha subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity. *J Exp Med.* 1998;187(2):271-275.

722. Chevigné A, Jacquet A. Emerging roles of the protease allergen Der p 1 in house dust mite-induced airway inflammation. *J Allergy Clin Immunol.* 2018;142(2):398-400.

723. Hewitt CR, Brown AP, Hart BJ, Pritchard DI. A major house dust mite allergen disrupts the immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases. *J Exp Med.* 1995;182(5):1537-1544.

724. Serhan N, Basso L, Sibilano R, et al. House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation. *Nat Immunol.* 2019;20(11):1435-1443.

725. Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. *Nat Med.* 2009;15(4):410-416.

726. Pulsawat P, Theeraapisakkun M, Nony E, et al. Characterization of the house dust mite allergen Der p 21 produced in Pichia pastoris. *Protein Expr Purif.* 2014;101:8-13.

727. Soongrung T, Mongkorntanyatip K, Peepim T, et al. The Blomia tropicalis allergen Blo t 7 stimulates innate immune signalling pathways through TLR2. *Clin Exp Allergy.* 2018;48(4):464-474.

728. Pulsawat P, Soongrung T, Satitsuksanoa P, et al. The house dust mite allergen Der p 5 binds lipid ligands and stimulates airway epithelial cells through a TLR2-dependent pathway. *Clin Exp Allergy.* 2019;49(3):378-390.
729. Zakzuk J, Benedetti I, Fernández-Caldas E, Caraballo L. The influence of chitin on the immune response to the house dust mite allergen Blo T 12. *Int Arch Allergy Immunol.* 2014;163(2): 119-129.

730. Gour N, Lajoie S, Smole U, et al. Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases. *Sci Immunol.* 2018;3(20).

731. Kim G, Hong M, Kashif A, et al. Der f 38 Is a Novel TLR4-Binding Allergen Related to Allergy Pathogenesis from Dermatophagoides farinae. *Int J Mol Sci.* 2021;22(16).

732. Casset A, Mari A, Purohit A, et al. Varying allergen composition and content affects the in vivo allergenic activity of commercial Dermatophagoides pteronyssinus extracts. *Int Arch Allergy Immunol.* 2012;159(3):253-262.

733. Huang HJ, Resch-Marat Y, Rodriguez-Dominguez A, et al. Underestimation of house dust mite-specific IgE with extract-based ImmunoCAPs compared with molecular ImmunoCAPs. *J Allergy Clin Immunol.* 2018;142(5):1656-1659.e1659.

734. Soto-Quiros M, Avila L, Platts-Mills TA, et al. High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus. *J Allergy Clin Immunol.* 2012;129(6):1499-1505.e1495.

735. Mourao EMM, Rosario NA. Conjunctival Provocation Test With Blomia tropicalis. *Front Allergy.* 2021;2:673462.

736. Zakzuk J, Lozano A, Caraballo L. Allergological Importance of Invertebrate Glutathione Transferases in Tropical Environments. *Front Allergy.* 2021;2:695262.

737. Platts-Mills TA, Thomas WR, Alberse RC, Vervloet D, Champman MD. Dust mite allergens and asthma: report of a second international workshop. *J Allergy Clin Immunol.* 1992;89:1046-1060.

738. Kerrebijn K. Endogenous factors in childhood CNSLD. In: NGM O, van der Lende R, eds. *Bronchitis III, The Netherlands: Royal Vangorcum Assen*; 1970:38-48.

739. Charpin D, Kleisbauer JP, Lanteaume A, et al. Asthma and allergy to house-dust mites in populations living in high altitudes. *Chest.* 1988;93(4):758-761.

740. Piacentini GL, Del Giudice MJ, Bodini A, et al. Exhaled NO reduced on allergen avoidance. *Allergy.* 2001;56(3):251-252.

741. Glesner J, Vailes LD, Schlachter C, et al. Antigenic Determinants of Der p 1: Specificity and Cross-Reactivity Associated with IgE Antibody Recognition. *J Immunol.* 2017;198(3):1334-1344.

742. Smith AM, Benjamin DC, Hozic N, et al. The molecular basis of antigenic cross-reactivity between the group 2 mite allergens. *J Allergy Clin Immunol.* 2001;107(6):977-984.

743. Cochran DG Cockroaches their biology, distribution and control. In. Geneva, World Health Organization (document number: WHO/CDS/CPC/WHOPES/99.3); 1999.

744. Sporik R, Squillace SP, Ingram JM, Rakes G, Honsinger RW, Platts-Mills TA. Mite, cat, and cockroach exposure, allergen sensitization, and asthma in children: a case-control study of three schools. *Thorax.* 1999;54(8):675-680.

745. Pomés A, Melén E, Vailes LD, Retief JD, Arruda LK, Chapman MD. Novel allergen structures with tandem amino acid repeats derived from German and American cockroach. *J Biol Chem.* 1998;273(46):30801-30807.

746. Satinover SM, Reefer AJ, Pomés A, Chapman MD, Platts-Mills TA, Woodfolk JA. Specific IgE and IgG antibody-binding patterns to recombinant cockroach allergens. *J Allergy Clin Immunol.* 2005;115(4):803-809.

747. Gustchina A, Li M, Wünschmann S, Chapman MD, Pomés A, Wlodawer A. Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition. *J Mol Biol.* 2005;348(2):433-444.

748. Glesner J, Wünschmann S, Li M, et al. Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with

monoclonal antibodies that inhibit IgE antibody binding. *PLoS One.* 2011;6(7):e22223.

749. Li M, Gustchina A, Alexandratos J, et al. Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. *J Biol Chem.* 2008;283(33):22806-22814.

750. Do DC, Yang S, Yao X, Hamilton RG, Schroeder JT, Gao P. N-glycan in cockroach allergen regulates human basophil function. *Immun Inflamm Dis.* 2017;5(4):386-399.

751. Jeng KC, Liu MT, Wu CH, Wong DW, Lan JL. American cockroach Cr-PI allergen induces lymphocyte proliferation and cytokine production in atopic patients. *Clin Exp Allergy.* 1996;26(3):349-356.

752. Hindley J, Wünschmann S, Satinover SM, et al. Bla g 6: a troponin C allergen from *Blattella germanica* with IgE binding calcium dependence. *J Allergy Clin Immunol.* 2006;117(6):1389-1395.

753. Sookrung N, Chaicumpa W, Tungtrongchitr A, et al. *Periplaneta americana* arginine kinase as a major cockroach allergen among Thai patients with major cockroach allergies. *Environ Health Perspect.* 2006;114(6):875-880.

754. Glesner J, Filep S, Vailes LD, et al. Allergen content in German cockroach extracts and sensitization profiles to a new expanded set of cockroach allergens determine *in vitro* extract potency for IgE reactivity. *J Allergy Clin Immunol.* 2019;143(4):1474-1481.e1478.

755. Binder M, Mahler V, Hayek B, et al. Molecular and immunological characterization of arginine kinase from the Indianmeal moth, *Plodia interpunctella*, a novel cross-reactive invertebrate pan-allergen. *J Immunol.* 2001;167(9):5470-5477.

756. Sudha VT, Arora N, Gaur SN, Pasha S, Singh BP. Identification of a serine protease as a major allergen (Per a 10) of *Periplaneta americana*. *Allergy.* 2008;63(6):768-776.

757. Jeong KY, Kim CR, Park J, Han IS, Park JW, Yong TS. Identification of novel allergenic components from German cockroach fecal extract by a proteomic approach. *Int Arch Allergy Immunol.* 2013;161(4):315-324.

758. Fang Y, Long C, Bai X, et al. Two new types of allergens from the cockroach, *Periplaneta americana*. *Allergy.* 2015;70(12):1674-1678.

759. Pomés A, Schulten V, Glesner J, et al. IgE and T Cell reactivity to a comprehensive panel of cockroach allergens in relation to disease. *Front Immunol.* 2020;11:621700.

760. Bernton HS, Brown H. Insect allergy - Preliminary studies of the cockroach. *J Allergy.* 1964;35:506-513.

761. Kang B, Vellody D, Homburger H, Yunginger JW. Cockroach cause of allergic asthma. Its specificity and immunologic profile. *J Allergy Clin Immunol.* 1979;63(2):80-86.

762. Pomés A, Glesner J, Calatroni A, et al. Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort. *J Allergy Clin Immunol.* 2019;144(4):935-944.

763. Lee MF, Song PP, Hwang GY, Lin SJ, Chen YH. Sensitization to Per a 2 of the American cockroach correlates with more clinical severity among airway allergic patients in Taiwan. *Ann Allergy Asthma Immunol.* 2012;108(4):243-248.

764. Hulett AC, Dockhorn RJ. House dust, mite (*D. farinae*) and cockroach allergy in a midwestern population. *Ann Allergy.* 1979;42(3):160-165.

765. Call RS, Smith TF, Morris E, Chapman MD, Platts-Mills TA. Risk factors for asthma in inner city children. *J Pediatr.* 1992;121(6):862-866.

766. Gelber LE, Seltzer LH, Bouzoukis JK, Pollart SM, Chapman MD, Platts-Mills TA. Sensitization and exposure to indoor allergens as risk factors for asthma among patients presenting to hospital. *Am Rev Respir Dis.* 1993;147(3):573-578.

767. Gruchalla RS, Pongracic J, Plaut M, et al. Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. *J Allergy Clin Immunol.* 2005;115(3):478-485.

768. Rosenstreich DL, Eggleston P, Kattan M, et al. The role of cockroach allergy and exposure to cockroach allergen in causing
729. Zakzuk J, Benedetti I, Fernández-Caldas E, Caraballo L. The influence of chitin on the immune response to the house dust mite allergen Blo T 12. *Int Arch Allergy Immunol.* 2014;163(2): 119-129.

730. Gour N, Lajoie S, Smole U, et al. Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases. *Sci Immunol.* 2018;3(20).

731. Kim G, Hong M, Kashif A, et al. Der f 38 Is a Novel TLR4-Binding Allergen Related to Allergy Pathogenesis from Dermatophagoides farinae. *Int J Mol Sci.* 2021;22(16).

732. Casset A, Mari A, Purohit A, et al. Varying allergen composition and content affects the in vivo allergenic activity of commercial Dermatophagoides pteronyssinus extracts. *Int Arch Allergy Immunol.* 2012;159(3):253-262.

733. Huang HJ, Resch-Marat Y, Rodriguez-Dominguez A, et al. Underestimation of house dust mite-specific IgE with extract-based ImmunoCAPs compared with molecular ImmunoCAPs. *J Allergy Clin Immunol.* 2018;142(5):1656-1659.e1659.

734. Soto-Quiros M, Avila L, Platts-Mills TA, et al. High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus. *J Allergy Clin Immunol.* 2012;129(6):1499-1505.e1495.

735. Mourao EMM, Rosario NA. Conjunctival Provocation Test With Blomia tropicalis. *Front Allergy.* 2021;2:673462.

736. Zakzuk J, Lozano A, Caraballo L. Allergological Importance of Invertebrate Glutathione Transferases in Tropical Environments. *Front Allergy.* 2021;2:695262.

737. Platts-Mills TA, Thomas WR, Alberse RC, Vervloet D, Champman MD. Dust mite allergens and asthma: report of a second international workshop. *J Allergy Clin Immunol.* 1992;89:1046-1060.

738. Kerrebijn K. Endogenous factors in childhood CNSLD. In: NGM O, van der Lende R, eds. *Bronchitis III, The Netherlands: Royal Vangorcum Assen*; 1970:38-48.

739. Charpin D, Kleisbauer JP, Lanteaume A, et al. Asthma and allergy to house-dust mites in populations living in high altitudes. *Chest.* 1988;93(4):758-761.

740. Piacentini GL, Del Giudice MJ, Bodini A, et al. Exhaled NO reduced on allergen avoidance. *Allergy.* 2001;56(3):251-252.

741. Glesner J, Vailes LD, Schlachter C, et al. Antigenic Determinants of Der p 1: Specificity and Cross-Reactivity Associated with IgE Antibody Recognition. *J Immunol.* 2017;198(3):1334-1344.

742. Smith AM, Benjamin DC, Hozic N, et al. The molecular basis of antigenic cross-reactivity between the group 2 mite allergens. *J Allergy Clin Immunol.* 2001;107(6):977-984.

743. Cochran DG Cockroaches their biology, distribution and control. In. Geneva, World Health Organization (document number: WHO/CDS/CPC/WHOPES/99.3); 1999.

744. Sporik R, Squillace SP, Ingram JM, Rakes G, Honsinger RW, Platts-Mills TA. Mite, cat, and cockroach exposure, allergen sensitization, and asthma in children: a case-control study of three schools. *Thorax.* 1999;54(8):675-680.

745. Pomés A, Melén E, Vailes LD, Retief JD, Arruda LK, Chapman MD. Novel allergen structures with tandem amino acid repeats derived from German and American cockroach. *J Biol Chem.* 1998;273(46):30801-30807.

746. Satinover SM, Reefer AJ, Pomés A, Chapman MD, Platts-Mills TA, Woodfolk JA. Specific IgE and IgG antibody-binding patterns to recombinant cockroach allergens. *J Allergy Clin Immunol.* 2005;115(4):803-809.

747. Gustchina A, Li M, Wünschmann S, Chapman MD, Pomés A, Wlodawer A. Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition. *J Mol Biol.* 2005;348(2):433-444.

748. Glesner J, Wünschmann S, Li M, et al. Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with

monoclonal antibodies that inhibit IgE antibody binding. *PLoS One.* 2011;6(7):e22223.

749. Li M, Gustchina A, Alexandratos J, et al. Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. *J Biol Chem.* 2008;283(33):22806-22814.

750. Do DC, Yang S, Yao X, Hamilton RG, Schroeder JT, Gao P. N-glycan in cockroach allergen regulates human basophil function. *Immun Inflamm Dis.* 2017;5(4):386-399.

751. Jeng KC, Liu MT, Wu CH, Wong DW, Lan JL. American cockroach Cr-PI allergen induces lymphocyte proliferation and cytokine production in atopic patients. *Clin Exp Allergy.* 1996;26(3):349-356.

752. Hindley J, Wünschmann S, Satinover SM, et al. Bla g 6: a troponin C allergen from *Blattella germanica* with IgE binding calcium dependence. *J Allergy Clin Immunol.* 2006;117(6):1389-1395.

753. Sookrung N, Chaicumpa W, Tungtrongchitr A, et al. *Periplaneta americana* arginine kinase as a major cockroach allergen among Thai patients with major cockroach allergies. *Environ Health Perspect.* 2006;114(6):875-880.

754. Glesner J, Filep S, Vailes LD, et al. Allergen content in German cockroach extracts and sensitization profiles to a new expanded set of cockroach allergens determine *in vitro* extract potency for IgE reactivity. *J Allergy Clin Immunol.* 2019;143(4):1474-1481.e1478.

755. Binder M, Mahler V, Hayek B, et al. Molecular and immunological characterization of arginine kinase from the Indianmeal moth, *Plodia interpunctella*, a novel cross-reactive invertebrate pan-allergen. *J Immunol.* 2001;167(9):5470-5477.

756. Sudha VT, Arora N, Gaur SN, Pasha S, Singh BP. Identification of a serine protease as a major allergen (Per a 10) of *Periplaneta americana*. *Allergy.* 2008;63(6):768-776.

757. Jeong KY, Kim CR, Park J, Han IS, Park JW, Yong TS. Identification of novel allergenic components from German cockroach fecal extract by a proteomic approach. *Int Arch Allergy Immunol.* 2013;161(4):315-324.

758. Fang Y, Long C, Bai X, et al. Two new types of allergens from the cockroach, *Periplaneta americana*. *Allergy.* 2015;70(12):1674-1678.

759. Pomés A, Schulten V, Glesner J, et al. IgE and T Cell reactivity to a comprehensive panel of cockroach allergens in relation to disease. *Front Immunol.* 2020;11:621700.

760. Bernton HS, Brown H. Insect allergy - Preliminary studies of the cockroach. *J Allergy.* 1964;35:506-513.

761. Kang B, Vellody D, Homburger H, Yunginger JW. Cockroach cause of allergic asthma. Its specificity and immunologic profile. *J Allergy Clin Immunol.* 1979;63(2):80-86.

762. Pomés A, Glesner J, Calatroni A, et al. Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort. *J Allergy Clin Immunol.* 2019;144(4):935-944.

763. Lee MF, Song PP, Hwang GY, Lin SJ, Chen YH. Sensitization to Per a 2 of the American cockroach correlates with more clinical severity among airway allergic patients in Taiwan. *Ann Allergy Asthma Immunol.* 2012;108(4):243-248.

764. Hulett AC, Dockhorn RJ. House dust, mite (*D. farinae*) and cockroach allergy in a midwestern population. *Ann Allergy.* 1979;42(3):160-165.

765. Call RS, Smith TF, Morris E, Chapman MD, Platts-Mills TA. Risk factors for asthma in inner city children. *J Pediatr.* 1992;121(6):862-866.

766. Gelber LE, Seltzer LH, Bouzoukis JK, Pollart SM, Chapman MD, Platts-Mills TA. Sensitization and exposure to indoor allergens as risk factors for asthma among patients presenting to hospital. *Am Rev Respir Dis.* 1993;147(3):573-578.

767. Gruchalla RS, Pongracic J, Plaut M, et al. Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. *J Allergy Clin Immunol.* 2005;115(3):478-485.

768. Rosenstreich DL, Eggleston P, Kattan M, et al. The role of cockroach allergy and exposure to cockroach allergen in causing
morbidity among inner-city children with asthma. *N Engl J Med*. 1997;336(19):1356-1363.

769. Liao C, Hu H, Huang Z, et al. Shrimp and cockroach co-sensitization in Southern China: Association with moth sensitization. *Allergy Asthma Proc*. 2020;41(3):e54-e60.

770. Acevedo N, Mohr J, Zakzuk J, et al. Proteomic and immunochemical characterization of glutathione transferase as a new allergen of the nematode Ascaris lumbricoides. *PLoS One*. 2013;8(11):e78353.

771. Westritschnig K, Sibanda E, Thomas W, et al. Analysis of the sensitization profile towards allergens in central Africa. *Clin Exp Allergy*. 2003;33(1):22-27.

772. Barbosa MC, Santos AB, Ferriani VP, Pomés A, Chapman MD, Arruda LK. Efficacy of recombinant allergens for diagnosis of cockroach allergy in patients with asthma and/or rhinitis. *Int Arch Allergy Immunol*. 2013;161(3):213-219.

773. Acevedo N, Erler A, Briza P, Puccio F, Ferreira F, Caraballo L. Allergenicity of *Ascaris lumbricoides* tropomyosin and IgE sensitization among asthmatic patients in a tropical environment. *Int Arch Allergy Immunol*. 2011;154(3):195-206.

774. Pomés A, Arruda LK. Investigating cockroach allergens: aiming to improve diagnosis and treatment of cockroach allergic patients. *Methods*. 2014;66(1):75-85.

775. Ahumada V, García E, Dennis R, et al. IgE responses to Ascaris and mite tropomyosins are risk factors for asthma. *Clin Exp Allergy*. 2015;45(7):1189-1200.

776. Birrueta G, Frazier A, Pomés A, et al. Variability in German Cockroach Extract Composition Greatly Impacts T Cell Potency in Cockroach-Allergic Donors. *Front Immunol*. 2019;10:313.

777. Mindaye ST, David NA, Zarkesh Esfahani SA, et al. Measurement of German cockroach allergens and their isoforms in allergen extracts with mass spectrometry. *Clin Exp Allergy*. 2020;50(6):741-751.

778. Chuang JG, Su SN, Chiang BL, Lee HJ, Chow LP. Proteome mining for novel IgE-binding proteins from the German cockroach (*Blattella germanica*) and allergen profiling of patients. *Proteomics*. 2010;10(21):3854-3867.

779. Finn PW, Boudreau JO, He H, et al. Children at risk for asthma: home allergen levels, lymphocyte proliferation, and wheeze. *J Allergy Clin Immunol*. 2000;105(5):933-942.

780. Pomés A, Schal C. *Cockroach and Other Inhalant Insect Allergens*, in *Allergens and Allergen Immunotherapy for Allergic Diseases, Subcutaneous, Sublingual and Oral*, L.D. Lockey R, Editor. CRC Press/Taylor & Francis Group; 2020.

781. Srivastava D, Gaur SN, Arora N, Singh BP. Clinico-immunological changes post-immunotherapy with *Periplaneta americana*. *Eur J Clin Invest*. 2011;41(8):879-888.

782. Meechan P, Tungtrongchitr A, Chaisri U, et al. Intranasal, liposome-adjuvanted cockroach allergy vaccines made of refined major allergen and whole-body extract of *Periplaneta americana*. *Int Arch Allergy Immunol*. 2013;161(4):351-362.

783. Konradsen JR, Fujisawa T, van Hage M, et al. Allergy to furry animals: New insights, diagnostic approaches, and challenges. *J Allergy Clin Immunol*. 2015;135(3):616-625.

784. Polovic N, Wadén K, Binnmyr J, et al. Dog saliva - an important source of dog allergens. *Allergy*. 2013;68(5):585-592.

785. Zahradnik E, Raulf M. Respiratory Allergens from Furred Mammals: Environmental and Occupational Exposure. *Vet Sci*. 2017;4(3).

786. Almqvist C, Wickman M, Perfetti L, et al. Worsening of asthma in children allergic to cats, after indirect exposure to cat at school. *Am J Respir Crit Care Med*. 2001;163(3 Pt 1):694-698.

787. Ritz BR, Hoelscher B, Frye C, Meyer I, Heinrich J. Allergic sensitization owing to 'second-hand' cat exposure in schools. *Allergy*. 2002;57(4):357-361.

788. Pecquet C. New pets and allergies. *Eur J Dermatol*. 2012;22(1):14-22.

789. Maeda Y, Akiyama K. Anaphylaxis after a cat bite. *Allergol Int*. 2012;61:511-512.

790. Guida G, Nebiolo F, Heffler E, Bergia R, Rolla G. Anaphylaxis after a horse bite. *Allergy*. 2005;60(8):1088-1089.

791. Torres JA, Sastre J, Vivanco F, Sanz Maroto A, de Las HM, Pastor-Vargas C. Clinical Characteristics of Patients Sensitized to Siberian Hamster. *J Investig Allergol Clin Immunol*. 2016;26(2):113-115.

792. Butt A, Rashid D, Lockey RF. Do hypoallergenic cats and dogs exist? *Ann Allergy Asthma Immunol*. 2012;108(2):74-76.

793. Zahradnik E, Sander I, Brüning T, Raulf M. Allergen Levels in the Hair of Different Cattle Breeds. *Int Arch Allergy Immunol*. 2015;167(1):9-15.

794. Zahradnik E, Janssen-Weets B, Sander I, et al. Lower allergen levels in hypoallergenic Curly Horses? A comparison among breeds by measurements of horse allergens in hair and air samples. *PLoS One*. 2018;13(12):e0207871.

795. Hilger C, Kohnen M, Grigioni F, Lehners C, Hentges F. Allergic cross-reactions between cat and pig serum albumin. Study at the protein and DNA levels. *Allergy*. 1997;52(2):179-187.

796. Martini M, Swiontek K, Antonicelli L, et al. Lysozyme, a new allergen in donkey's milk. *Clin Exp Allergy*. 2018;48(11):1521-1523.

797. Khurana T, Newman-Lindsay S, Young PR, Slater JE. The NPC2 protein: A novel dog allergen. *Ann Allergy Asthma Immunol*. 2016;116(5):440-446.e442.

798. Schmitz R, Ellert U, Kalcklösch M, Dahm S, Thamm M. Patterns of sensitization to inhalant and food allergens - findings from the German Health Interview and Examination Survey for Children and Adolescents. *Int Arch Allergy Immunol*. 2013;162(3):263-270.

799. Melén E, Bergström A, Kull I, et al. Male sex is strongly associated with IgE-sensitization to airborne but not food allergens: results up to age 24 years from the BAMSE birth cohort. *Clin Transl Allergy*. 2020;10:15.

800. Warm K, Lindberg A, Lundbäck B, Rönmark E. Increase in sensitization to common airborne allergens among adults - two population-based studies 15 years apart. *Allergy Asthma Clin Immunol*. 2013;9(1):20.

801. Heinzerling LM, Burbach GJ, Edenharter G, et al. GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe. *Allergy*. 2009;64(10):1498-1506.

802. Dávila I, Domínguez-Ortega J, Navarro-Pulido A, et al. Consensus document on dog and cat allergy. *Allergy*. 2018;73(6):1206-1222.

803. Schoos AM, Nwaru BI, Borres MP. Component-resolved diagnostics in pet allergy: Current perspectives and future directions. *J Allergy Clin Immunol*. 2021;147(4):1164-1173.

804. Grönlund H, Adédoyin J, Reininger R, et al. Higher immunoglobulin E antibody levels to recombinant Fel d 1 in cat-allergic children with asthma compared with rhinoconjunctivitis. *Clin Exp Allergy*. 2008;38(8):1275-1281.

805. Suzuki S, Nwaru BI, Ekerljung L, et al. Characterization of sensitization to furry animal allergen components in an adult population. *Clin Exp Allergy*. 2019;49(4):495-505.

806. Bjerg A, Winberg A, Berthold M, Mattsson L, Borres MP, Rönmark E. A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren. *Pediatr Allergy Immunol*. 2015;26(6):557-563.

807. Tsolakis N, Malinovschi A, Nordvall L, et al. Sensitization to minor cat allergen components is associated with type-2 biomarkers in young asthmatics. *Clin Exp Allergy*. 2018;48(9):1186-1194.

808. Patelis A, Gunnbjornsdottir M, Alving K, et al. Allergen extract vs. component sensitization and airway inflammation, responsiveness and new-onset respiratory disease. *Clin Exp Allergy*. 2016;46(5):730-740.

809. Wisniewski JA, Agrawal R, Minnicozzi S, et al. Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis. *Clin Exp Allergy*. 2013;43(10):1160-1170.
morbidity among inner-city children with asthma. *N Engl J Med*. 1997;336(19):1356-1363.

769. Liao C, Hu H, Huang Z, et al. Shrimp and cockroach co-sensitization in Southern China: Association with moth sensitization. *Allergy Asthma Proc*. 2020;41(3):e54-e60.

770. Acevedo N, Mohr J, Zakzuk J, et al. Proteomic and immunochemical characterization of glutathione transferase as a new allergen of the nematode Ascaris lumbricoides. *PLoS One*. 2013;8(11):e78353.

771. Westritschnig K, Sibanda E, Thomas W, et al. Analysis of the sensitization profile towards allergens in central Africa. *Clin Exp Allergy*. 2003;33(1):22-27.

772. Barbosa MC, Santos AB, Ferriani VP, Pomés A, Chapman MD, Arruda LK. Efficacy of recombinant allergens for diagnosis of cockroach allergy in patients with asthma and/or rhinitis. *Int Arch Allergy Immunol*. 2013;161(3):213-219.

773. Acevedo N, Erler A, Briza P, Puccio F, Ferreira F, Caraballo L. Allergicicity of *Ascaris lumbricoides* tropomyosin and IgE sensitization among asthmatic patients in a tropical environment. *Int Arch Allergy Immunol*. 2011;154(3):195-206.

774. Pomés A, Arruda LK. Investigating cockroach allergens: aiming to improve diagnosis and treatment of cockroach allergic patients. *Methods*. 2014;66(1):75-85.

775. Ahumada V, García E, Dennis R, et al. IgE responses to Ascaris and mite tropomyosins are risk factors for asthma. *Clin Exp Allergy*. 2015;45(7):1189-1200.

776. Birrueta G, Frazier A, Pomés A, et al. Variability in German Cockroach Extract Composition Greatly Impacts T Cell Potency in Cockroach-Allergic Donors. *Front Immunol*. 2019;10:313.

777. Mindaye ST, David NA, Zarkesh Esfahani SA, et al. Measurement of German cockroach allergens and their isoforms in allergen extracts with mass spectrometry. *Clin Exp Allergy*. 2020;50(6):741-751.

778. Chuang JG, Su SN, Chiang BL, Lee HJ, Chow LP. Proteome mining for novel IgE-binding proteins from the German cockroach (*Blattella germanica*) and allergen profiling of patients. *Proteomics*. 2010;10(21):3854-3867.

779. Finn PW, Boudreau JO, He H, et al. Children at risk for asthma: home allergen levels, lymphocyte proliferation, and wheeze. *J Allergy Clin Immunol*. 2000;105(5):933-942.

780. Pomés A, Schal C. *Cockroach and Other Inhalant Insect Allergens*, in *Allergens and Allergen Immunotherapy for Allergic Diseases, Subcutaneous, Sublingual and Oral*, L.D. Lockey R, Editor. CRC Press/Taylor & Francis Group; 2020.

781. Srivastava D, Gaur SN, Arora N, Singh BP. Clinico-immunological changes post-immunotherapy with *Periplaneta americana*. *Eur J Clin Invest*. 2011;41(8):879-888.

782. Meechan P, Tungtrongchitr A, Chaisri U, et al. Intranasal, liposome-adjuvanted cockroach allergy vaccines made of refined major allergen and whole-body extract of *Periplaneta americana*. *Int Arch Allergy Immunol*. 2013;161(4):351-362.

783. Konradsen JR, Fujisawa T, van Hage M, et al. Allergy to furry animals: New insights, diagnostic approaches, and challenges. *J Allergy Clin Immunol*. 2015;135(3):616-625.

784. Polovic N, Wadén K, Binnmyr J, et al. Dog saliva - an important source of dog allergens. *Allergy*. 2013;68(5):585-592.

785. Zahradnik E, Raulf M. Respiratory Allergens from Furred Mammals: Environmental and Occupational Exposure. *Vet Sci*. 2017;4(3).

786. Almqvist C, Wickman M, Perfetti L, et al. Worsening of asthma in children allergic to cats, after indirect exposure to cat at school. *Am J Respir Crit Care Med*. 2001;163(3 Pt 1):694-698.

787. Ritz BR, Hoelscher B, Frye C, Meyer I, Heinrich J. Allergic sensitization owing to 'second-hand' cat exposure in schools. *Allergy*. 2002;57(4):357-361.

788. Pecquet C. New pets and allergies. *Eur J Dermatol*. 2012;22(1):14-22.

789. Maeda Y, Akiyama K. Anaphylaxis after a cat bite. *Allergol Int*. 2012;61:511-512.

790. Guida G, Nebiolo F, Heffler E, Bergia R, Rolla G. Anaphylaxis after a horse bite. *Allergy*. 2005;60(8):1088-1089.

791. Torres JA, Sastre J, Vivanco F, Sanz Maroto A, de Las HM, Pastor-Vargas C. Clinical Characteristics of Patients Sensitized to Siberian Hamster. *J Investig Allergol Clin Immunol*. 2016;26(2):113-115.

792. Butt A, Rashid D, Lockey RF. Do hypoallergenic cats and dogs exist? *Ann Allergy Asthma Immunol*. 2012;108(2):74-76.

793. Zahradnik E, Sander I, Brüning T, Raulf M. Allergen Levels in the Hair of Different Cattle Breeds. *Int Arch Allergy Immunol*. 2015;167(1):9-15.

794. Zahradnik E, Janssen-Weets B, Sander I, et al. Lower allergen levels in hypoallergenic Curly Horses? A comparison among breeds by measurements of horse allergens in hair and air samples. *PLoS One*. 2018;13(12):e0207871.

795. Hilger C, Kohnen M, Grigioni F, Lehners C, Hentges F. Allergic cross-reactions between cat and pig serum albumin. Study at the protein and DNA levels. *Allergy*. 1997;52(2):179-187.

796. Martini M, Swiontek K, Antonicelli L, et al. Lysozyme, a new allergen in donkey's milk. *Clin Exp Allergy*. 2018;48(11):1521-1523.

797. Khurana T, Newman-Lindsay S, Young PR, Slater JE. The NPC2 protein: A novel dog allergen. *Ann Allergy Asthma Immunol*. 2016;116(5):440-446.e442.

798. Schmitz R, Ellert U, Kalcklösch M, Dahm S, Thamm M. Patterns of sensitization to inhalant and food allergens - findings from the German Health Interview and Examination Survey for Children and Adolescents. *Int Arch Allergy Immunol*. 2013;162(3):263-270.

799. Melén E, Bergström A, Kull I, et al. Male sex is strongly associated with IgE-sensitization to airborne but not food allergens: results up to age 24 years from the BAMSE birth cohort. *Clin Transl Allergy*. 2020;10:15.

800. Warm K, Lindberg A, Lundbäck B, Rönmark E. Increase in sensitization to common airborne allergens among adults - two population-based studies 15 years apart. *Allergy Asthma Clin Immunol*. 2013;9(1):20.

801. Heinzerling LM, Burbach GJ, Edenharter G, et al. GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe. *Allergy*. 2009;64(10):1498-1506.

802. Dávila I, Domínguez-Ortega J, Navarro-Pulido A, et al. Consensus document on dog and cat allergy. *Allergy*. 2018;73(6):1206-1222.

803. Schoos AM, Nwaru BI, Borres MP. Component-resolved diagnostics in pet allergy: Current perspectives and future directions. *J Allergy Clin Immunol*. 2021;147(4):1164-1173.

804. Grönlund H, Adédoyin J, Reininger R, et al. Higher immunoglobulin E antibody levels to recombinant Fel d 1 in cat-allergic children with asthma compared with rhinoconjunctivitis. *Clin Exp Allergy*. 2008;38(8):1275-1281.

805. Suzuki S, Nwaru BI, Ekerljung L, et al. Characterization of sensitization to furry animal allergen components in an adult population. *Clin Exp Allergy*. 2019;49(4):495-505.

806. Bjerg A, Winberg A, Berthold M, Mattsson L, Borres MP, Rönmark E. A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren. *Pediatr Allergy Immunol*. 2015;26(6):557-563.

807. Tsolakis N, Malinovschi A, Nordvall L, et al. Sensitization to minor cat allergen components is associated with type-2 biomarkers in young asthmatics. *Clin Exp Allergy*. 2018;48(9):1186-1194.

808. Patelis A, Gunnbjornsdottir M, Alving K, et al. Allergen extract vs. component sensitization and airway inflammation, responsiveness and new-onset respiratory disease. *Clin Exp Allergy*. 2016;46(5):730-740.

809. Wisniewski JA, Agrawal R, Minnicozzi S, et al. Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis. *Clin Exp Allergy*. 2013;43(10):1160-1170.
810. Casale TB, Cruz C. Anaphylaxis to cat in a child with exclusive sensitivity to Fel d 1. *J Allergy Clin Immunol Pract.* 2013;1(4):416-417.

811. Käck U, Asarnoj A, Grönlund H, et al. Molecular allergy diagnostics refine characterization of children sensitized to dog dander. *J Allergy Clin Immunol.* 2018;142(4):1113-1120.e1119.

812. Schoos AM, Bønnelykke K, Chawes BL, Stokholm J, Bisgaard H, Kristensen B. Precision allergy: Separate allergies to male and female dogs. *J Allergy Clin Immunol Pract.* 2017;5(6):1754-1756.

813. Schoos AM, Chawes BL, Bloch J, et al. Children Monosensitized to Can f 5 Show Different Reactions to Male and Female Dog Allergen Extract Provocation: A Randomized Controlled Trial. *J Allergy Clin Immunol Pract.* 2020;8(5):1592-1597.e1592.

814. Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, et al. Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity. *Clin Exp Allergy.* 2008;38(2):374-381.

815. Schoos AM, Kattan JD, Gimenez G, Sampson HA. Sensitization phenotypes based on protein groups and associations to allergic diseases in children. *J Allergy Clin Immunol.* 2016;137(4):1277-1280.

816. Nordlund B, Konradsen JR, Kull I, et al. IgE antibodies to animal-derived lipocalin, kallikrein and secretoglobin are markers of bronchial inflammation in severe childhood asthma. *Allergy.* 2012;67(5):661-669.

817. Konradsen JR, Nordlund B, Onell A, Borres MP, Grönlund H, Hedlin G. Severe childhood asthma and allergy to furry animals: refined assessment using molecular-based allergy diagnostics. *Pediatr Allergy Immunol.* 2014;25(2):187-192.

818. Nwaru BI, Suzuki S, Ekerljung L, et al. Furry Animal Allergen Component Sensitization and Clinical Outcomes in Adult Asthma and Rhinitis. *J Allergy Clin Immunol Pract.* 2019;7(4):1230-1238. e1234.

819. Burnett M. Wegienka G, Havstad S, et al. Relationship of dog- and cat-specific IgE and IgG4 levels to allergic symptoms on pet exposure. *J Allergy Clin Immunol Pract.* 2013;1(4):350-353.

820. Zahradnik E, Sander I, Kleinmüller O, et al. Animal Allergens, Endotoxin, and β-(1,3)-Glucan in Small Animal Practices: Exposure Levels at Work and in Homes of Veterinary Staff. *Ann Work Expo Health.* 2022;66(1):27-40.

821. Nilsson OB, Binnmyr J, Zoltowska A, Saarne T, van Hage M, Grönlund H. Characterization of the dog lipocalin allergen Can f 6: the role in cross-reactivity with cat and horse. *Allergy.* 2012;67(6):751-757.

822. Swiontek K, Kler S, Lehners C, Ollert M, Hentges F, Hilger C. Component-resolved diagnosis using guinea-pig allergens elucidates allergen sensitization profiles in allergy to furry animals. *Clin Exp Allergy.* 2021;51(6):829-835.

823. Hilger C, Kler S, Arumugam K, et al. Identification and isolation of a Fel d 1-like molecule as a major rabbit allergen. *J Allergy Clin Immunol.* 2014;133(3):759-766.

824. Zahradnik E, Sander I, Bruckmaier L, et al. Development of a sandwich ELISA to measure exposure to occupational cow hair allergens. *Int Arch Allergy Immunol.* 2011;155(3):225-233.

825. Uriarte SA, Grönlund H, Wintersand A, Bronge J, Sastre J. Clinical and Immunologic Changes due to Subcutaneous Immunotherapy With Cat and Dog Extracts Using an Ultrarush Up-Dosing Phase: A Real-Life Study. *J Investig Allergol Clin Immunol.* 2022;32(2): 133-140.

826. Uriarte SA, Sastre J. Subcutaneous Immunotherapy With High-Dose Cat and Dog Extracts: A Real-life Study. *J Investig Allergol Clin Immunol.* 2020;30(3):169-174.

827. Satyaraj E, Wedner HJ, Bousquet J. Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen. *Allergy.* 2019;74 Suppl 107(Suppl 107):5-17.

828. Mora C, Tittensor DP, Adl S, Simpson AG, Worm B. How many species are there on Earth and in the ocean? *PLoS Biol.* 2011;9(8):e1001127.

829. Canova C, Heinrich J, Anto JM, et al. The influence of sensitization to pollens and moulds on seasonal variations in asthma attacks. *Eur Respir J.* 2013;42(4):935-945.

830. D'Amato G, Chong-Neto HJ, Monge Ortega OP, et al. The effects of climate change on respiratory allergy and asthma induced by pollen and mold allergens. *Allergy.* 2020;75(9):2219-2228.

831. Holme JA, Øya E, Afanou AKJ, Øvrevik J, Eduard W. Characterization and pro-inflammatory potential of indoor mold particles. *Indoor Air.* 2020;30(4):662-681.

832. Low SY, Dannemiller K, Yao M, Yamamoto N, Peccia J. The allergicicity of Aspergillus fumigatus conidia is influenced by growth temperature. *Fungal Biol.* 2011;115(7):625-632.

833. Grewling Ł, Bogawski P, Szymańska A, Nowak M, Kostecki Ł, Smith M. Particle size distribution of the major Alternaria alternata allergen, Alt a 1, derived from airborne spores and subspore fragments. *Fungal Biol.* 2020;124(3-4):219-227.

834. Twaroch TE, Arcalis E, Sterflinger K, Stöger E, Swoboda I, Valenta R. Predominant localization of the major Alternaria allergen Alt a 1 in the cell wall of airborne spores. *J Allergy Clin Immunol.* 2012;129:1148-1149.

835. O'Driscoll BR, Powell G, Chew F, et al. Comparison of skin prick tests with specific serum immunoglobulin E in the diagnosis of fundamental sensitization in patients with severe asthma. *Clin Exp Allergy.* 2009;39(11):1677-1683.

836. Kespohl S, Raulf M. Mold allergens and their importance in molecular allergy diagnosis. In: Kleine-Tebbe J, Jakob T, eds. *Molecular Allergy Diagnostics*. Springer International Publishing Switzerland; 2017:445-458.

837. Chou H, Tam MF, Lee SS, et al. A vacuolar serine protease (Rho m 2) is a major allergen of Rhodotorula mucilaginosa and belongs to a class of highly conserved pan-fungal allergens. *Int Arch Allergy Immunol.* 2005;138(2):134-141.

838. Gupta R, Sharma V, Sridhara S, Singh BP, Arora N. Identification of serine protease as a major allergen of Curvularia lunata. *Allergy.* 2004;59(4):421-427.

839. Shen HD, Chou H, Tam MF, Chang CY, Lai HY, Wang SR. Molecular and immunological characterization of Pen ch 18, the vacuolar serine protease major allergen of Penicillium chrysogenum. *Allergy.* 2003;58(10):993-1002.

840. Simon-Nobbe B, Denk U, Pöll V, Rid M, Breitenbach M. The spectrum of fungal allergy. *Int Arch Allergy Immunol.* 2008;145(1):58-86.

841. Twaroch TE, Curin M, Valenta R, Swoboda I. Mold allergens in respiratory allergy: from structure to therapy. *Allergy Asthma Immunol Res.* 2015;7(3):205-220.

842. Hoff M, Trüeb RM, Ballmer-Weber BK, Vieths S, Wuethrich B. Immediate-type hypersensitivity reaction to ingestion of mycoprotein (Quorn) in a patient allergic to molds caused by acidic ribosomal protein P2. *J Allergy Clin Immunol.* 2003;111(5):1106-1110.

843. Karmakar B, Saha B, Jana K, Gupta BS. Identification and biochemical characterization of Asp t 36, a new fungal allergen from Aspergillus terreus. *J Biol Chem.* 2020;295(51):17852-17864.

844. Simon-Nobbe B, Probst G, Kajava AV, et al. IgE-binding epitopes of enolases, a class of highly conserved fungal allergens. *J Allergy Clin Immunol.* 2000;106(5):887-895.

845. Simon-Nobbe B, Denk U, Schneider PB, et al. NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarum. *J Biol Chem.* 2006;281(24):16354-16360.

846. Schneider PB, Denk U, Breitenbach M, et al. Alternaria alternata NADP-dependent mannitol dehydrogenase is an important fungal allergen. *Clin Exp Allergy.* 2006;36(12):1513-1524.

847. Hemmann S, Blaser K, Crameri R. Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes. *Am J Respir Crit Care Med.* 1997;156(6):1956-1962.

848. Chou H, Tam MF, Chiang CH, Chou CT, Tai HY, Shen HD. Transaldolases are novel and immunoglobulin E cross-reacting fungal allergens. *Clin Exp Allergy.* 2011;41(5):739-749.
810. Casale TB, Cruz C. Anaphylaxis to cat in a child with exclusive sensitivity to Fel d 1. *J Allergy Clin Immunol Pract.* 2013;1(4):416-417.

811. Käck U, Asarnoj A, Grönlund H, et al. Molecular allergy diagnostics refine characterization of children sensitized to dog dander. *J Allergy Clin Immunol.* 2018;142(4):1113-1120.e1119.

812. Schoos AM, Bønnelykke K, Chawes BL, Stokholm J, Bisgaard H, Kristensen B. Precision allergy: Separate allergies to male and female dogs. *J Allergy Clin Immunol Pract.* 2017;5(6):1754-1756.

813. Schoos AM, Chawes BL, Bloch J, et al. Children Monosensitized to Can f 5 Show Different Reactions to Male and Female Dog Allergen Extract Provocation: A Randomized Controlled Trial. *J Allergy Clin Immunol Pract.* 2020;8(5):1592-1597.e1592.

814. Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, et al. Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity. *Clin Exp Allergy.* 2008;38(2):374-381.

815. Schoos AM, Kattan JD, Gimenez G, Sampson HA. Sensitization phenotypes based on protein groups and associations to allergic diseases in children. *J Allergy Clin Immunol.* 2016;137(4):1277-1280.

816. Nordlund B, Konradsen JR, Kull I, et al. IgE antibodies to animal-derived lipocalin, kallikrein and secretoglobin are markers of bronchial inflammation in severe childhood asthma. *Allergy.* 2012;67(5):661-669.

817. Konradsen JR, Nordlund B, Onell A, Borres MP, Grönlund H, Hedlin G. Severe childhood asthma and allergy to furry animals: refined assessment using molecular-based allergy diagnostics. *Pediatr Allergy Immunol.* 2014;25(2):187-192.

818. Nwaru BI, Suzuki S, Ekerljung L, et al. Furry Animal Allergen Component Sensitization and Clinical Outcomes in Adult Asthma and Rhinitis. *J Allergy Clin Immunol Pract.* 2019;7(4):1230-1238. e1234.

819. Burnett M. Wegienka G, Havstad S, et al. Relationship of dog- and cat-specific IgE and IgG4 levels to allergic symptoms on pet exposure. *J Allergy Clin Immunol Pract.* 2013;1(4):350-353.

820. Zahradnik E, Sander I, Kleinmüller O, et al. Animal Allergens, Endotoxin, and β-(1,3)-Glucan in Small Animal Practices: Exposure Levels at Work and in Homes of Veterinary Staff. *Ann Work Expo Health.* 2022;66(1):27-40.

821. Nilsson OB, Binnmyr J, Zoltowska A, Saarne T, van Hage M, Grönlund H. Characterization of the dog lipocalin allergen Can f 6: the role in cross-reactivity with cat and horse. *Allergy.* 2012;67(6):751-757.

822. Swiontek K, Kler S, Lehners C, Ollert M, Hentges F, Hilger C. Component-resolved diagnosis using guinea-pig allergens elucidates allergen sensitization profiles in allergy to furry animals. *Clin Exp Allergy.* 2021;51(6):829-835.

823. Hilger C, Kler S, Arumugam K, et al. Identification and isolation of a Fel d 1-like molecule as a major rabbit allergen. *J Allergy Clin Immunol.* 2014;133(3):759-766.

824. Zahradnik E, Sander I, Bruckmaier L, et al. Development of a sandwich ELISA to measure exposure to occupational cow hair allergens. *Int Arch Allergy Immunol.* 2011;155(3):225-233.

825. Uriarte SA, Grönlund H, Wintersand A, Bronge J, Sastre J. Clinical and Immunologic Changes due to Subcutaneous Immunotherapy With Cat and Dog Extracts Using an Ultrarush Up-Dosing Phase: A Real-Life Study. *J Investig Allergol Clin Immunol.* 2022;32(2): 133-140.

826. Uriarte SA, Sastre J. Subcutaneous Immunotherapy With High-Dose Cat and Dog Extracts: A Real-life Study. *J Investig Allergol Clin Immunol.* 2020;30(3):169-174.

827. Satyaraj E, Wedner HJ, Bousquet J. Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen. *Allergy.* 2019;74 Suppl 107(Suppl 107):5-17.

828. Mora C, Tittensor DP, Adl S, Simpson AG, Worm B. How many species are there on Earth and in the ocean? *PLoS Biol.* 2011;9(8):e1001127.

829. Canova C, Heinrich J, Anto JM, et al. The influence of sensitization to pollens and moulds on seasonal variations in asthma attacks. *Eur Respir J.* 2013;42(4):935-945.

830. D'Amato G, Chong-Neto HJ, Monge Ortega OP, et al. The effects of climate change on respiratory allergy and asthma induced by pollen and mold allergens. *Allergy.* 2020;75(9):2219-2228.

831. Holme JA, Øya E, Afanou AKJ, Øvrevik J, Eduard W. Characterization and pro-inflammatory potential of indoor mold particles. *Indoor Air.* 2020;30(4):662-681.

832. Low SY, Dannemiller K, Yao M, Yamamoto N, Peccia J. The allergicicity of Aspergillus fumigatus conidia is influenced by growth temperature. *Fungal Biol.* 2011;115(7):625-632.

833. Grewling Ł, Bogawski P, Szymańska A, Nowak M, Kostecki Ł, Smith M. Particle size distribution of the major Alternaria alternata allergen, Alt a 1, derived from airborne spores and subspore fragments. *Fungal Biol.* 2020;124(3-4):219-227.

834. Twaroch TE, Arcalis E, Sterflinger K, Stöger E, Swoboda I, Valenta R. Predominant localization of the major Alternaria allergen Alt a 1 in the cell wall of airborne spores. *J Allergy Clin Immunol.* 2012;129:1148-1149.

835. O'Driscoll BR, Powell G, Chew F, et al. Comparison of skin prick tests with specific serum immunoglobulin E in the diagnosis of fundamental sensitization in patients with severe asthma. *Clin Exp Allergy.* 2009;39(11):1677-1683.

836. Kespohl S, Raulf M. Mold allergens and their importance in molecular allergy diagnosis. In: Kleine-Tebbe J, Jakob T, eds. *Molecular Allergy Diagnostics*. Springer International Publishing Switzerland; 2017:445-458.

837. Chou H, Tam MF, Lee SS, et al. A vacuolar serine protease (Rho m 2) is a major allergen of Rhodotorula mucilaginosa and belongs to a class of highly conserved pan-fungal allergens. *Int Arch Allergy Immunol.* 2005;138(2):134-141.

838. Gupta R, Sharma V, Sridhara S, Singh BP, Arora N. Identification of serine protease as a major allergen of Curvularia lunata. *Allergy.* 2004;59(4):421-427.

839. Shen HD, Chou H, Tam MF, Chang CY, Lai HY, Wang SR. Molecular and immunological characterization of Pen ch 18, the vacuolar serine protease major allergen of Penicillium chrysogenum. *Allergy.* 2003;58(10):993-1002.

840. Simon-Nobbe B, Denk U, Pöll V, Rid M, Breitenbach M. The spectrum of fungal allergy. *Int Arch Allergy Immunol.* 2008;145(1):58-86.

841. Twaroch TE, Curin M, Valenta R, Swoboda I. Mold allergens in respiratory allergy: from structure to therapy. *Allergy Asthma Immunol Res.* 2015;7(3):205-220.

842. Hoff M, Trüeb RM, Ballmer-Weber BK, Vieths S, Wuethrich B. Immediate-type hypersensitivity reaction to ingestion of mycoprotein (Quorn) in a patient allergic to molds caused by acidic ribosomal protein P2. *J Allergy Clin Immunol.* 2003;111(5):1106-1110.

843. Karmakar B, Saha B, Jana K, Gupta BS. Identification and biochemical characterization of Asp t 36, a new fungal allergen from Aspergillus terreus. *J Biol Chem.* 2020;295(51):17852-17864.

844. Simon-Nobbe B, Probst G, Kajava AV, et al. IgE-binding epitopes of enolases, a class of highly conserved fungal allergens. *J Allergy Clin Immunol.* 2000;106(5):887-895.

845. Simon-Nobbe B, Denk U, Schneider PB, et al. NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarum. *J Biol Chem.* 2006;281(24):16354-16360.

846. Schneider PB, Denk U, Breitenbach M, et al. Alternaria alternata NADP-dependent mannitol dehydrogenase is an important fungal allergen. *Clin Exp Allergy.* 2006;36(12):1513-1524.

847. Hemmann S, Blaser K, Crameri R. Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes. *Am J Respir Crit Care Med.* 1997;156(6):1956-1962.

848. Chou H, Tam MF, Chiang CH, Chou CT, Tai HY, Shen HD. Transaldolases are novel and immunoglobulin E cross-reacting fungal allergens. *Clin Exp Allergy.* 2011;41(5):739-749.
849. Chou H, Wu KG, Yeh CC, et al. The transaldolase, a novel allergen of Fusarium proliferatum, demonstrates IgE cross-reactivity with its human analogue. *PLoS One*. 2014;9(7):e103488.

850. Asturias JA II, Ferrer A, et al. Diagnosis of Alternaria alternata sensitization with natural and recombinant Alt a 1 allergens. *J Allergy Clin Immunol*. 2005;115:1210-1217. doi:10.1016/j.jaci.2005.02.012

851. Hernandez-Ramirez G, Barber D, Tome-Amat J, Garrido-Arandia M, Diaz-Perales A. Alternaria as an Inducer of Allergic Sensitization. *J Fungi (Basel)*. 2021;7(10).

852. Chruszcz M, Chapman MD, Osinski T, et al. Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi. *J Allergy Clin Immunol*. 2012;130(1):241-247.e249.

853. Crameri R. Recombinant Aspergillus fumigatus allergens: from the nucleotide sequences to clinical applications. *Int Arch Allergy Immunol*. 1998;115(2):99-114.

854. Crameri R, Hemmann S, Ismail C, Menz G, Blaser K. Disease-specific recombinant allergens for the diagnosis of allergic bronchopulmonary aspergillosis. *Int Immunol*. 1998;10(8):1211-1216.

855. Agarwal R, Chakrabarti A, Shah A, et al. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. *Clin Exp Allergy*. 2013;43(8):850-873.

856. Muthu V, Singh P, Choudhary H, et al. Diagnostic Cutoffs and Clinical Utility of Recombinant Aspergillus fumigatus Antigens in the Diagnosis of Allergic Bronchopulmonary Aspergillosis. *J Allergy Clin Immunol Pract*. 2020;8(2):579-587.

857. Esch RE, Codina R. Fungal raw materials used to produce allergen extracts. *Ann Allergy Asthma Immunol*. 2017;118(4):399-405.

858. Kespohl S, Maryska S, Zahradnik E, Sander I, Brüning T, Raulf-Heimsoth M. Biochemical and immunological analysis of mould skin prick test solution: current status of standardization. *Clin Exp Allergy*. 2013;43(11):1286-1296.

859. Vailes LD, Perzanowski MS, Wheatley LM, Platts-Mills TA, Chapman MD. IgE and IgG antibody responses to recombinant Alt a 1 as a marker of sensitization to Alternaria in asthma and atopic dermatitis. *Clin Exp Allergy*. 2001;31(12):1891-1895.

860. López Couso VP, Tortajada-Girbés M, Rodríguez Gil D, Martínez Quesada J, Palacios PR. Fungi Sensitization in Spain: Importance of the Alternaria alternata Species and Its Major Allergen Alt a 1 in the Allergenicity. *J Fungi (Basel)*. 2021;7(8).

861. Tabar Al, Prieto L, Alba P, et al. Double-blind, randomized, placebo-controlled trial of allergen-specific immunotherapy with the major allergen Alt a 1. *J Allergy Clin Immunol*. 2019;144(1):216-223.e213.

862. Morales-Amparano MB, Huerta-Ocampo J, Pastor-Palacios G, Teran LM. The Role of Enolases in Allergic Disease. *J Allergy Clin Immunol Pract*. 2021;9(8):3026-3032.

863. Muthu V, Sehgal IS, Dhooria S, Aggarwal AN, Agarwal R. Utility of recombinant Aspergillus fumigatus antigens in the diagnosis of allergic bronchopulmonary aspergillosis: A systematic review and diagnostic test accuracy meta-analysis. *Clin Exp Allergy*. 2018;48(9):1107-1136.

864. Joest M. Allergic bronchopulmonary aspergillosis (ABPA) in an atopic patient with difficult-to-expectorate airway secretions. *Allergol Select*. 2021;5:157-161.

865. Rosenberg M, Patterson R, Mintzer R, Cooper BJ, Roberts M, Harris KE. Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. *Ann Intern Med*. 1977;86(4):405-414.

866. Kurup VP, Banerjee B, Hemmann S, Greenberger PA, Blaser K, Crameri R. Selected recombinant Aspergillus fumigatus allergens bind specifically to IgE in ABPA. *Clin Exp Allergy*. 2000;30(7):988-993.

867. Klimek L, Werfel T, Vogelberg C, Jung K. Authorised allergen products for intracutaneous testing may no longer be available in Germany: Allergy textbooks have to be re-written. *Allergo J Int*. 2015;24(3):84-93.

868. Kespohl S, Liebers V, Maryska S, et al. What should be tested in patients with suspected mold exposure? Usefulness of serological markers for the diagnosis. *Allergol Select*. 2022;6:118-132.

869. Kespohl S, Raulf M. Mold Sensitization in Asthmatic and Non-asthmatic Subjects Diagnosed with Extract-Based Versus Component-Based Allergens. *Adv Exp Med Biol*. 2019;1153:79-89.

870. Oh J, Byrd AL, Deming C, et al. Biogeography and individuality shape function in the human skin metagenome. *Nature*. 2014;514(7520):59-64.

871. De Benedetto A, Kubo A, Beck LA. Skin barrier disruption: a requirement for allergen sensitisation? *J Invest Dermatol*. 2012;132(3 Pt 2):949-963.

872. Kong HH, Oh J, Deming C, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. *Genome Res*. 2012;22(5):850-859.

873. Langan SM, Irvine AD, Weidinger S. Atopic dermatitis. *Lancet*. 2020;396(10247):345-360.

874. Laughter MR, Maymone MBC, Mashayekhi S, et al. The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990-2017. *Br J Dermatol*. 2021;184(2):304-309.

875. Patrick GJ, Archer NK, Miller LS. Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis. *J Invest Dermatol*. 2021;141(2):274-284.

876. Brodská P, Panzner P, Pizinger K, Schmid-Grendelmeier P. IgE-mediated sensitization to malassezia in atopic dermatitis: more common in male patients and in head and neck type. *Dermatitis*. 2014;25(3):120-126.

877. Glatz M, Buchner M, von Bartenwerffer W, et al. Malassezia spp.-specific immunoglobulin E level is a marker for severity of atopic dermatitis in adults. *Acta Derm Venereol*. 2015;95(2):191-196.

878. Kaffenberger BH, Mathis J, Zirwas MJ. A retrospective descriptive study of oral azole antifungal agents in patients with patch test-negative head and neck predominant atopic dermatitis. *J Am Acad Dermatol*. 2014;71(3):480-483.

879. Cabañes FJ. Malassezia yeasts: how many species infect humans and animals? *PLoS Pathog*. 2014;10(2):e1003892.

880. Saunders CW, Scheynius A, Heitman J. Malassezia fungi are specialized to live on skin and associated with dandruff, eczema, and other skin diseases. *PLoS Pathog*. 2012;8(6):e1002701.

881. Findley K, Oh J, Yang J, et al. Topographic diversity of fungal and bacterial communities in human skin. *Nature*. 2013;498(7454):367-370.

882. Gaitanis G, Magiatis P, Hantschke M, Bassukas ID, Velegraki A. The Malassezia genus in skin and systemic diseases. *Clin Microbiol Rev*. 2012;25(1):106-141.

883. Glatz M, Bosshard PP, Hoetzenecker W, Schmid-Grendelmeier P. The Role of Malassezia spp. in Atopic Dermatitis. *J Clin Med*. 2015;4(6):1217-1228.

884. Lang CCV, Masenga J, Semango G, et al. Evidence for different immune signatures and sensitization patterns in sub-Saharan African vs. Central European atopic dermatitis patients. *J Eur Acad Dermatol Venereol*. 2021;35(2):e140-e142.

885. Glaser AG, Limacher A, Flückiger S, Scheynius A, Scapozza L, Crameri R. Analysis of the cross-reactivity and of the 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family. *Biochem J*. 2006;396(1):41-49.

886. Limacher A, Glaser AG, Meier C, et al. Cross-reactivity and 1.4-A crystal structure of Malassezia sympodialis thioredoxin (Mala s 13), a member of a new pan-allergen family. *J Immunol*. 2007;178(1):389-396.

887. Vilhelmsson M, Glaser AG, Martinez DB, et al. Mutational analysis of amino acid residues involved in IgE-binding to the Malassezia sympodialis allergen Mala s 11. *Mol Immunol*. 2008;46(2):294-303.
849. Chou H, Wu KG, Yeh CC, et al. The transaldolase, a novel allergen of Fusarium proliferatum, demonstrates IgE cross-reactivity with its human analogue. *PLoS One*. 2014;9(7):e103488.

850. Asturias JA II, Ferrer A, et al. Diagnosis of Alternaria alternata sensitization with natural and recombinant Alt a 1 allergens. *J Allergy Clin Immunol*. 2005;115:1210-1217. doi:10.1016/j.jaci.2005.02.012

851. Hernandez-Ramirez G, Barber D, Tome-Amat J, Garrido-Arandia M, Diaz-Perales A. Alternaria as an Inducer of Allergic Sensitization. *J Fungi (Basel)*. 2021;7(10).

852. Chruszcz M, Chapman MD, Osinski T, et al. Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi. *J Allergy Clin Immunol*. 2012;130(1):241-247.e249.

853. Crameri R. Recombinant Aspergillus fumigatus allergens: from the nucleotide sequences to clinical applications. *Int Arch Allergy Immunol*. 1998;115(2):99-114.

854. Crameri R, Hemmann S, Ismail C, Menz G, Blaser K. Disease-specific recombinant allergens for the diagnosis of allergic bronchopulmonary aspergillosis. *Int Immunol*. 1998;10(8):1211-1216.

855. Agarwal R, Chakrabarti A, Shah A, et al. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. *Clin Exp Allergy*. 2013;43(8):850-873.

856. Muthu V, Singh P, Choudhary H, et al. Diagnostic Cutoffs and Clinical Utility of Recombinant Aspergillus fumigatus Antigens in the Diagnosis of Allergic Bronchopulmonary Aspergillosis. *J Allergy Clin Immunol Pract*. 2020;8(2):579-587.

857. Esch RE, Codina R. Fungal raw materials used to produce allergen extracts. *Ann Allergy Asthma Immunol*. 2017;118(4):399-405.

858. Kespohl S, Maryska S, Zahradnik E, Sander I, Brüning T, Raulf-Heimsoth M. Biochemical and immunological analysis of mould skin prick test solution: current status of standardization. *Clin Exp Allergy*. 2013;43(11):1286-1296.

859. Vailes LD, Perzanowski MS, Wheatley LM, Platts-Mills TA, Chapman MD. IgE and IgG antibody responses to recombinant Alt a 1 as a marker of sensitization to Alternaria in asthma and atopic dermatitis. *Clin Exp Allergy*. 2001;31(12):1891-1895.

860. López Couso VP, Tortajada-Girbés M, Rodríguez Gil D, Martínez Quesada J, Palacios PR. Fungi Sensitization in Spain: Importance of the Alternaria alternata Species and Its Major Allergen Alt a 1 in the Allergenicity. *J Fungi (Basel)*. 2021;7(8).

861. Tabar Al, Prieto L, Alba P, et al. Double-blind, randomized, placebo-controlled trial of allergen-specific immunotherapy with the major allergen Alt a 1. *J Allergy Clin Immunol*. 2019;144(1):216-223.e213.

862. Morales-Amparano MB, Huerta-Ocampo J, Pastor-Palacios G, Teran LM. The Role of Enolases in Allergic Disease. *J Allergy Clin Immunol Pract*. 2021;9(8):3026-3032.

863. Muthu V, Sehgal IS, Dhooria S, Aggarwal AN, Agarwal R. Utility of recombinant Aspergillus fumigatus antigens in the diagnosis of allergic bronchopulmonary aspergillosis: A systematic review and diagnostic test accuracy meta-analysis. *Clin Exp Allergy*. 2018;48(9):1107-1136.

864. Joest M. Allergic bronchopulmonary aspergillosis (ABPA) in an atopic patient with difficult-to-expectorate airway secretions. *Allergol Select*. 2021;5:157-161.

865. Rosenberg M, Patterson R, Mintzer R, Cooper BJ, Roberts M, Harris KE. Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. *Ann Intern Med*. 1977;86(4):405-414.

866. Kurup VP, Banerjee B, Hemmann S, Greenberger PA, Blaser K, Crameri R. Selected recombinant Aspergillus fumigatus allergens bind specifically to IgE in ABPA. *Clin Exp Allergy*. 2000;30(7):988-993.

867. Klimek L, Werfel T, Vogelberg C, Jung K. Authorised allergen products for intracutaneous testing may no longer be available in Germany: Allergy textbooks have to be re-written. *Allergo J Int*. 2015;24(3):84-93.

868. Kespohl S, Liebers V, Maryska S, et al. What should be tested in patients with suspected mold exposure? Usefulness of serological markers for the diagnosis. *Allergol Select*. 2022;6:118-132.

869. Kespohl S, Raulf M. Mold Sensitization in Asthmatic and Non-asthmatic Subjects Diagnosed with Extract-Based Versus Component-Based Allergens. *Adv Exp Med Biol*. 2019;1153:79-89.

870. Oh J, Byrd AL, Deming C, et al. Biogeography and individuality shape function in the human skin metagenome. *Nature*. 2014;514(7520):59-64.

871. De Benedetto A, Kubo A, Beck LA. Skin barrier disruption: a requirement for allergen sensitisation? *J Invest Dermatol*. 2012;132(3 Pt 2):949-963.

872. Kong HH, Oh J, Deming C, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. *Genome Res*. 2012;22(5):850-859.

873. Langan SM, Irvine AD, Weidinger S. Atopic dermatitis. *Lancet*. 2020;396(10247):345-360.

874. Laughter MR, Maymone MBC, Mashayekhi S, et al. The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990-2017. *Br J Dermatol*. 2021;184(2):304-309.

875. Patrick GJ, Archer NK, Miller LS. Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis. *J Invest Dermatol*. 2021;141(2):274-284.

876. Brodská P, Panzner P, Pizinger K, Schmid-Grendelmeier P. IgE-mediated sensitization to malassezia in atopic dermatitis: more common in male patients and in head and neck type. *Dermatitis*. 2014;25(3):120-126.

877. Glatz M, Buchner M, von Bartenwerffer W, et al. Malassezia spp.-specific immunoglobulin E level is a marker for severity of atopic dermatitis in adults. *Acta Derm Venereol*. 2015;95(2):191-196.

878. Kaffenberger BH, Mathis J, Zirwas MJ. A retrospective descriptive study of oral azole antifungal agents in patients with patch test-negative head and neck predominant atopic dermatitis. *J Am Acad Dermatol*. 2014;71(3):480-483.

879. Cabañes FJ. Malassezia yeasts: how many species infect humans and animals? *PLoS Pathog*. 2014;10(2):e1003892.

880. Saunders CW, Scheynius A, Heitman J. Malassezia fungi are specialized to live on skin and associated with dandruff, eczema, and other skin diseases. *PLoS Pathog*. 2012;8(6):e1002701.

881. Findley K, Oh J, Yang J, et al. Topographic diversity of fungal and bacterial communities in human skin. *Nature*. 2013;498(7454):367-370.

882. Gaitanis G, Magiatis P, Hantschke M, Bassukas ID, Velegraki A. The Malassezia genus in skin and systemic diseases. *Clin Microbiol Rev*. 2012;25(1):106-141.

883. Glatz M, Bosshard PP, Hoetzenecker W, Schmid-Grendelmeier P. The Role of Malassezia spp. in Atopic Dermatitis. *J Clin Med*. 2015;4(6):1217-1228.

884. Lang CCV, Masenga J, Semango G, et al. Evidence for different immune signatures and sensitization patterns in sub-Saharan African vs. Central European atopic dermatitis patients. *J Eur Acad Dermatol Venereol*. 2021;35(2):e140-e142.

885. Glaser AG, Limacher A, Flückiger S, Scheynius A, Scapozza L, Crameri R. Analysis of the cross-reactivity and of the 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family. *Biochem J*. 2006;396(1):41-49.

886. Limacher A, Glaser AG, Meier C, et al. Cross-reactivity and 1.4-A crystal structure of Malassezia sympodialis thioredoxin (Mala s 13), a member of a new pan-allergen family. *J Immunol*. 2007;178(1):389-396.

887. Vilhelmsson M, Glaser AG, Martinez DB, et al. Mutational analysis of amino acid residues involved in IgE-binding to the Malassezia sympodialis allergen Mala s 11. *Mol Immunol*. 2008;46(2):294-303.
888. Schmid-Grendelmeier P, Flückiger S, Disch R, et al. IgEmediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. *J Allergy Cin Immunol.* 2005;115(5):1068-1075.

889. Altrichter S, Schumacher P, Alraboni O, et al. Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients. *Clin Transl Allergy.* 2020;10:18.

890. Johansson C, Sandström MH, Bartosik J, et al. Atopy patch test reactions to Malassezia allergens differentiate subgroups of atopic dermatitis patients. *Br J Dermatol.* 2003;148(3):479-488.

891. Sehnal D, Bittrich S, Deshpande M, et al. Mol+ Viewer: modern web app for 3D visualization and analysis of large biomolecular structures. *Nucleic Acids Res.* 2021;49:W431-W437. doi:10.1093/nar/gkab314

892. Scheynius A, Johansson C, Buentke E, Zargari A, Linder MT. Atopic eczema/dermatitis syndrome and Malassezia. *Int Arch Allergy Immunol.* 2002;127(3):161-169.

893. Darabi K, Hostetler SG, Bechtel MA, Zirwas M. The role of Malassezia in atopic dermatitis affecting the head and neck of adults. *J Am Acad Dermatol.* 2009;60(1):125-136.

894. Seland C, Zargari A, Möllby R, Rasool O, Scheynius A. Higher pH level, corresponding to that on the skin of patients with atopic eczema, stimulates the release of Malassezia sympodialis allergens. *Allergy.* 2006;61(8):1002-1008.

895. Ramirez de Knott HM, McCormick TS, Kalka K, et al. Cutaneous hypersensitivity to Malassezia sympodialis and dust mite in adult atopic dermatitis with a textile pattern. *Contact Dermatitis.* 2006;54(2):92-99.

896. Svejgaard E, Larsen P, Deleuran M, Ternowitz T, Roed-Petersen J, Nilsson J. Treatment of head and neck dermatitis comparing itraconazole 200 mg and 400 mg daily for 1 week with placebo. *J Eur Acad Dermatol Venereol.* 2004;18(4):445-449.

897. Lintu P, Savolainen J, Kortekangas-Savolainen O, Kalimo K. Systemic ketoconazole is an effective treatment of atopic dermatitis with IgE-mediated hypersensitivity to yeasts. *Allergy.* 2001;56(6):512-517.

898. Buttafuoco A, Schmid-Grendelmeier P, Glatz M. *Ther Umsch.* 2016;73:463-468.

899. Sparber F, De Gregorio C, Steckholzer S, et al. The skin commensal yeast malassezia triggers a type 17 response that coordinates anti-fungal immunity and exacerbates skin inflammation. *Cell Host Microbe.* 2019;25(3):389-403.

900. Balaji H, Heratizadeh A, Wichmann K, et al. Malassezia sympodialis thioredoxin-specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis. *J Allergy Clin Immunol.* 2011;128(1):92-99.e94.

901. Bjerre RD, Bandier J, Skov L, Engstrand L, Johansen JD. The role of the skin microbiome in atopic dermatitis: a systematic review. *Br J Dermatol.* 2017;177(5):1272-1278.

902. Nordengrün MMS, Völker U, Bröker BM, Gómez-Gascón L. The quest for bacterial allergens. *Int J Med Microbiol.* 2018;308(6):738-750.

903. Rachid RS-VE, Chatila TA. The microbial origins of food allergy. *J Allergy Clin Immunol.* 2021;147(3):808-813. doi:10.1016/j.jaci.2020.12.624

904. Hoh RAJS, Lee J-Y, Martin BA, et al. Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy. *Sci Immunol.* 2020;5(45):eaay4209.

905. Petersen J, Ciacchi L, Tran MT, et al. T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease. *Nat Struct Mol Biol.* 2020;27(1):49-61.

906. Hua XGJ, Pu A, Yu G, Shi J. Allergy associations with the adult fecal microbiota: analysis of the American Gut Project. *EBioMedicine.*

907. FAO/WHO. *Edible Insects. Future Prospects for Food and Feed Security*. Food and Agriculture Organization of the United Nations; 2013:171.

908. Jongema Y. World list of edible insects. 2017. https://www.wur.nl/upload_mm/8/a/6/0dfc700-3929-4a74-8b69-f02fd35a1696_Worldwide%20list%20of%20edible%20insects%202017.pdf

909. Czolk R, Klueber J, Sørensen M, et al. IgE-mediated peanut allergy: current and novel predictive biomarkers for clinical phenotypes using multi-omics approaches. *Front Immunol.* 2021;11(3653):594350.

910. FDA. *Food Defect Levels Handbook*. FDA; 2018.

911. EFSA Panel on Dietetic Products NaANP, Nutrition, Nda A et al. Guidance on the preparation and submission of an application for authorisation of a novel food in the context of Regulation (EU) 2015/2283 (Revision 1)2. EFSA J. 2021;19(3):e06555. doi:10.2903/j.efsa.2021.6555

912. EFSA Panel on Nutrition NFaFAN, Turck D, Castenmiller J, et al. Safety of dried yellow mealworm (Tenebrio molitor larva) as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2021;19(1):e06343. doi:10.2903/j.efsa.2021.6343

913. Barennes H, Phimmasane M, Rajaonarivo C. Insect Consumption to Address Undernutrition, a National Survey on the Prevalence of Insect Consumption among Adults and Vendors in Laos. *PLoS One.* 2015;10(8):e0136458.

914. Ji K, Chen J, Li M, et al. Anaphylactic shock and lethal anaphylaxis caused by food consumption in China. *Trends Food Sci Technol.* 2009;20(5):227-231.

915. Lee SC, Kim SR, Park KH, Lee JH, Park JW. Clinical Features and Culprit Food Allergens of Korean Adult Food Allergy Patients: A Cross-Sectional Single-Institute Study. *Allergy Asthma Immunol Res.* 2019;11(5):723-735.

916. Jeong KY, Hong CS, Yong TS. Domestic arthropods and their allergens. *Protein Pept Lett.* 2007;14(10):934-942.

917. De Marchi L, Wangorsch A, Zoccatelli G. Allergens from Edible Insects: Cross-reactivity and Effects of Processing. *Curr Allergy Asthma Rep.* 2021;21(5):35.

918. Broekman H, Knulst AC, den Hartog Jager CF, et al. Primary respiratory and food allergy to mealworm. *J Allergy Clin Immunol.* 2017;140(2):600-603.e607.

919. Verhoeckx K, Broekman H, Knulst A, Houben G. Allergenicity assessment strategy for novel food proteins and protein sources. *Regul Toxicol Pharmacol.* 2016;79:118-124.

920. Phiriyangkul P et al. Effect of food thermal processing on allergenicity proteins in Bombay locust (*Patanga Succincta*). *Int J Food Eng.* 2015;1:23-28. doi:10.18178/ijfe.1.1.23-28

921. Kamemura N, Sugimoto M, Tamehiro N, et al. Cross-allergenicity of crustacean and the edible insect Gryllus bimaculatus in patients with shrimp allergy. *Mol Immunol.* 2019;106:127-134.

922. de Las Marinas MD, Cerdá JC, López-Matas MA, et al. Hexamerin-like protein 2, a cricket allergen involved in occupational and food allergy. *Clin Exp Allergy.* 2021;51(6):858-860.

923. De Marchi L, Mainente F, Leonardi M, et al. Allergenicity assessment of the edible cricket Acheta domesticus in terms of thermal and gastrointestinal processing and IgE cross-reactivity with shrimp. *Food Chem.* 2021;359:129878.

924. Srinroch C, Srisomsap C, Chokchaichamnankit D, Punyarit P, Phiriyangkul P. Identification of novel allergen in edible insect, Gryllus bimaculatus and its cross-reactivity with Macrobrachium spp. allergens. *Food Chem.* 2015;184:160-166.

925. Azzi A, Clark SA, Ellington WR, Chapman MS. The role of phosphagen specificity loops in arginine kinase. *Protein Sci.* 2004;13(3):575-585.

926. Zhao X, Li L, Kuang Z, Luo G, Li B. Proteomic and immunological identification of two new allergens from silkworm (Bombyx mori L.) pupae. *Cent Eur J Immunol.* 2015;40(1):30-34.

927. Jeong KY, Son M, Lee JY, Park KH, Lee JH, Park JW. Allergenic characterization of 27-kDa glycoprotein, a novel heat stable allergen, from the pupa of silkworm, *Bombyx mori*. *J Korean Med Sci.* 2016;31(1):18-24.
888. Schmid-Grendelmeier P, Flückiger S, Disch R, et al. IgEmediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. *J Allergy Clin Immunol.* 2005;115(5):1068-1075.

889. Altrichter S, Schumacher P, Alraboni O, et al. Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients. *Clin Transl Allergy.* 2020;10:18.

890. Johansson C, Sandström MH, Bartosik J, et al. Atopy patch test reactions to Malassezia allergens differentiate subgroups of atopic dermatitis patients. *Br J Dermatol.* 2003;148(3):479-488.

891. Sehnal D, Bittrich S, Deshpande M, et al. Mol+ Viewer: modern web app for 3D visualization and analysis of large biomolecular structures. *Nucleic Acids Res.* 2021;49:W431-W437. doi:10.1093/nar/gkab314

892. Scheynius A, Johansson C, Buentke E, Zargari A, Linder MT. Atopic eczema/dermatitis syndrome and Malassezia. *Int Arch Allergy Immunol.* 2002;127(3):161-169.

893. Darabi K, Hostetler SG, Bechtel MA, Zirwas M. The role of Malassezia in atopic dermatitis affecting the head and neck of adults. *J Am Acad Dermatol.* 2009;60(1):125-136.

894. Seland C, Zargari A, Möllby R, Rasool O, Scheynius A. Higher pH level, corresponding to that on the skin of patients with atopic eczema, stimulates the release of Malassezia sympodialis allergens. *Allergy.* 2006;61(8):1002-1008.

895. Ramirez de Knott HM, McCormick TS, Kalka K, et al. Cutaneous hypersensitivity to Malassezia sympodialis and dust mite in adult atopic dermatitis with a textile pattern. *Contact Dermatitis.* 2006;54(2):92-99.

896. Svejgaard E, Larsen P, Deleuran M, Ternowitz T, Roed-Petersen J, Nilsson J. Treatment of head and neck dermatitis comparing itraconazole 200 mg and 400 mg daily for 1 week with placebo. *J Eur Acad Dermatol Venereol.* 2004;18(4):445-449.

897. Lintu P, Savolainen J, Kortekangas-Savolainen O, Kalimo K. Systemic ketoconazole is an effective treatment of atopic dermatitis with IgE-mediated hypersensitivity to yeasts. *Allergy.* 2001;56(6):512-517.

898. Buttafuoco A, Schmid-Grendelmeier P, Glatz M. *Ther Umsch.* 2016;73:463-468.

899. Sparber F, De Gregorio C, Steckholzer S, et al. The skin commensal yeast malassezia triggers a type 17 response that coordinates anti-fungal immunity and exacerbates skin inflammation. *Cell Host Microbe.* 2019;25(3):389-403.

900. Balaji H, Heratizadeh A, Wichmann K, et al. Malassezia sympodialis thioredoxin-specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis. *J Allergy Clin Immunol.* 2011;128(1):92-99.e94.

901. Bjerre RD, Bandier J, Skov L, Engstrand L, Johansen JD. The role of the skin microbiome in atopic dermatitis: a systematic review. *Br J Dermatol.* 2017;177(5):1272-1278.

902. Nordengrün MMS, Völker U, Bröker BM, Gómez-Gascón L. The quest for bacterial allergens. *Int J Med Microbiol.* 2018;308(6):738-750.

903. Rachid RS-VE, Chatila TA. The microbial origins of food allergy. *J Allergy Clin Immunol.* 2021;147(3):808-813. doi:10.1016/j.jaci.2020.12.624

904. Hoh RAJS, Lee J-Y, Martin BA, et al. Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy. *Sci Immunol.* 2020;5(45):eaay4209.

905. Petersen J, Ciacchi L, Tran MT, et al. T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease. *Nat Struct Mol Biol.* 2020;27(1):49-61.

906. Hua XGJ, Pu A, Yu G, Shi J. Allergy associations with the adult fecal microbiota: analysis of the American Gut Project. *EBioMedicine.*

907. FAO/WHO. *Edible Insects. Future Prospects for Food and Feed Security*. Food and Agriculture Organization of the United Nations; 2013:171.

908. Jongema Y. World list of edible insects. 2017. https://www.wur.nl/upload_mm/8/a/6/0dfc700-3929-4a74-8b69-f02fd35a1696_Worldwide%20list%20of%20edible%20insects%202017.pdf

909. Czolk R, Klueber J, Sørensen M, et al. IgE-mediated peanut allergy: current and novel predictive biomarkers for clinical phenotypes using multi-omics approaches. *Front Immunol.* 2021;11(3653):594350.

910. FDA. *Food Defect Levels Handbook*. FDA; 2018.

911. EFSA Panel on Dietetic Products NaANP, Nutrition, Nda A et al. Guidance on the preparation and submission of an application for authorisation of a novel food in the context of Regulation (EU) 2015/2283 (Revision 1)2. EFSA J. 2021;19(3):e06555. doi:10.2903/j.efsa.2021.6555

912. EFSA Panel on Nutrition NFaFAN, Turck D, Castenmiller J, et al. Safety of dried yellow mealworm (Tenebrio molitor larva) as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2021;19(1):e06343. doi:10.2903/j.efsa.2021.6343

913. Barennes H, Phimmasane M, Rajaonarivo C. Insect Consumption to Address Undernutrition, a National Survey on the Prevalence of Insect Consumption among Adults and Vendors in Laos. *PLoS One.* 2015;10(8):e0136458.

914. Ji K, Chen J, Li M, et al. Anaphylactic shock and lethal anaphylaxis caused by food consumption in China. *Trends Food Sci Technol.* 2009;20(5):227-231.

915. Lee SC, Kim SR, Park KH, Lee JH, Park JW. Clinical Features and Culprit Food Allergens of Korean Adult Food Allergy Patients: A Cross-Sectional Single-Institute Study. *Allergy Asthma Immunol Res.* 2019;11(5):723-735.

916. Jeong KY, Hong CS, Yong TS. Domestic arthropods and their allergens. *Protein Pept Lett.* 2007;14(10):934-942.

917. De Marchi L, Wangorsch A, Zoccatelli G. Allergens from Edible Insects: Cross-reactivity and Effects of Processing. *Curr Allergy Asthma Rep.* 2021;21(5):35.

918. Broekman H, Knulst AC, den Hartog Jager CF, et al. Primary respiratory and food allergy to mealworm. *J Allergy Clin Immunol.* 2017;140(2):600-603.e607.

919. Verhoeckx K, Broekman H, Knulst A, Houben G. Allergenicity assessment strategy for novel food proteins and protein sources. *Regul Toxicol Pharmacol.* 2016;79:118-124.

920. Phiriyangkul P et al. Effect of food thermal processing on allergenicity proteins in Bombay locust (*Patanga Succincta*). *Int J Food Eng.* 2015;1:23-28. doi:10.18178/ijfe.1.1.23-28

921. Kamemura N, Sugimoto M, Tamehiro N, et al. Cross-allergenicity of crustacean and the edible insect Gryllus bimaculatus in patients with shrimp allergy. *Mol Immunol.* 2019;106:127-134.

922. de Las Marinas MD, Cerdá JC, López-Matas MA, et al. Hexamerin-like protein 2, a cricket allergen involved in occupational and food allergy. *Clin Exp Allergy.* 2021;51(6):858-860.

923. De Marchi L, Mainente F, Leonardi M, et al. Allergenicity assessment of the edible cricket Acheta domesticus in terms of thermal and gastrointestinal processing and IgE cross-reactivity with shrimp. *Food Chem.* 2021;359:129878.

924. Srinroch C, Srisomsap C, Chokchaichamnankit D, Punyarit P, Phiriyangkul P. Identification of novel allergen in edible insect, Gryllus bimaculatus and its cross-reactivity with Macrobrachium spp. allergens. *Food Chem.* 2015;184:160-166.

925. Azzi A, Clark SA, Ellington WR, Chapman MS. The role of phosphagen specificity loops in arginine kinase. *Protein Sci.* 2004;13(3):575-585.

926. Zhao X, Li L, Kuang Z, Luo G, Li B. Proteomic and immunological identification of two new allergens from silkworm (Bombyx mori L.) pupae. *Cent Eur J Immunol.* 2015;40(1):30-34.

927. Jeong KY, Son M, Lee JY, Park KH, Lee JH, Park JW. Allergenic characterization of 27-kDa glycoprotein, a novel heat stable allergen, from the pupa of silkworm, *Bombyx mori*. *J Korean Med Sci.* 2016;31(1):18-24.
928. Leoni C, Volpicella M, Dileo M, Gattulli BAR, Ceci LR. Chitinases as Food Allergens. *Molecules*. 2019;24(11).

929. Li MX, Hwang PM. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. *Gene*. 2015;571(2):153-166.

930. Burmester T. Evolution and function of the insect hexamerins. *EJE*. 1999;96(3):213-225.

931. Rane AS, Joshi RS, Giri AP. Molecular determinant for specificity: Differential interaction of α-amylases with their proteinaceous inhibitors. *Biochim Biophys Acta Gen Subj*. 1864;2020(12):129703.

932. Barre A, Pichereaux C, Simplicien M, Burlet-Schiltz O, Benoist H, Rougé P. A Proteomic- and Bioinformatic-Based Identification of Specific Allergens from Edible Insects: Probes for Future Detection as Food Ingredients. *Foods*. 2021;10(2).

933. de Gier S, Verhoeckx K. Insect (food) allergy and allergens. *Mol Immunol*. 2018;100:82-106.

934. Broekman H, Verhoeckx KC, den Hartog Jager CF, et al. Majority of shrimp-allergic patients are allergic to mealworm. *J Allergy Clin Immunol*. 2016;137(4):1261-1263.

935. Broekman H, Knulst AC, de Jong G, et al. Is mealworm or shrimp allergy indicative for food allergy to insects? *Mol Nutr Food Res*. 2017;61(9).

936. Nebbia S, Lamberti C, Giorgis V, et al. The cockroach allergen-like protein is involved in primary respiratory and food allergy to yellow mealworm (Tenebrio molitor). *Clin Exp Allergy*. 2019;49(10):1379-1382.

937. Bose U, Broadbent JA, Juhász A, et al. Protein extraction protocols for optimal proteome measurement and arginine kinase quantitation from cricket Acheta domesticus for food safety assessment. *Food Chem*. 2021;348:129110.

938. Broekman H, Knulst A, den Hartog JS, et al. Effect of thermal processing on mealworm allergenicity. *Mol Nutr Food Res*. 2015;59(9):1855-1864.

939. Pali-Schöll I, Meinlschmidt P, Larenas-Linnemann D, et al. Edible insects: Cross-recognition of IgE from crustacean- and house dust mite allergic patients, and reduction of allergenicity by food processing. *World Allergy Organ J*. 2019;12(1):100006.

940. Mankouri F, Sereme Y, Michel M, et al. Immediate Hypersensitivity to Mealworm and Cricket: Beyond Shrimp and House Dust Mite Cross-Reactivity. *J Investig Allergol Clin Immunol*. 2021;32(1):64-66.

941. Kung SJ, Fenemore B, Potter PC. Anaphylaxis to Mopane worms (*Imbrasia belina*). *Ann Allergy Asthma Immunol*. 2011;106:538-540.

942. Hustinx-Broekman HCHP, Allergenic risks of mealworm and other insects, in Universiteit Utrecht. doctoral thesis 201. Allergenic risks of mealworm and other insects, in Universiteit Utrecht. doctoral thesis 2017, Utrecht. https://dspace.library.uu.nl/handle/1874/349295.

943. Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. *J Allergy Clin Immunol*. 2010;126(6):1105-1118.

944. Schoemaker AA, Sprikkelman AB, Grimshaw KE, et al. Incidence and natural history of challenge-proven cow's milk allergy in European children-EuroPrevall birth cohort. *Allergy*. 2015;70(8):963-972.

945. Restani P, Beretta B, Fiocchi A, Ballabio C, Galli CL. Cross-reactivity between mammalian proteins. *Ann Allergy Asthma Immunol*. 2002;89(6 Suppl 1):11-15.

946. Tsabouri S, Douros K, Priftis KN. Cow's milk allergenicity. *Endoc Metab Immune Disord Drug Targets*. 2014;14(1):16-26.

947. Fiocchi A, Dahdah L, Albarini M, Martelli A. Cow's milk allergy in children and adults. *Chem Immunol Allergy*. 2015;101:114-123.

948. Bloom KA, Huang FR, Bencharitiwong R, et al. Effect of heat treatment on milk and egg proteins allergenicity. *Pediatr Allergy Immunol*. 2014;25(8):740-746.

949. Bijl E, van Valenberg HJ, Huppertz T, van Hooijdonk AC. Protein, casein, and micellar salts in milk: current content and historical perspectives. *J Dairy Sci*. 2013;96(9):5455-5464.

950. de Kruif CG, Huppertz T, Urban VS, Petukhov AV. Casein micelles and their internal structure. *Adv Colloid Interface Sci*. 2012;171-172:36-52.

951. Werfel SJ, Cooke SK, Sampson HA. Clinical reactivity to beef in children allergic to cow's milk. *J Allergy Clin Immunol*. 1997;99(3):293-300.

952. Restani P, Ballabio C, Tripodi S, Fiocchi A. Meat allergy. *Curr Opin Allergy Clin Immunol*. 2009;9(3):265-269.

953. Restani P, Ballabio C, Di Lorenzo C, Tripodi S, Fiocchi A. Molecular aspects of milk allergens and their role in clinical events. *Anal Bioanal Chem*. 2009;395(1):47-56.

954. Vicente-Serrano J, Caballero ML, Rodríguez-Pérez R, et al. Sensitization to serum albumins in children allergic to cow's milk and epithelia. *Pediatr Allergy Immunol*. 2007;18(6):503-507.

955. Chatchatee P, Järvinen KM, Bardina L, Vila L, Beyer K, Sampson HA. Identification of IgE and IgG binding epitopes on beta- and kappa-casein in cow's milk allergic patients. *Clin Exp Allergy*. 2001;31(8):1256-1262.

956. Chatchatee P, Järvinen KM, Bardina L, Beyer K, Sampson HA. Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow's milk allergy. *J Allergy Clin Immunol*. 2001;107(2):379-383.

957. Lorenz AR, Scheurer S, Vieths S. Food allergens: molecular and immunological aspects, allergen databases and cross-reactivity. *Chem Immunol Allergy*. 2015;101:18-29.

958. Kim JS, Nowak-Węgrzyn A, Sicherer SH, Noone S, Moshier EL, Sampson HA. Dietary baked milk accelerates the resolution of cow's milk allergy in children. *J Allergy Clin Immunol*. 2011;128(1):125-131.e122.

959. Ford LS, Bloom KA, Nowak-Węgrzyn AH, Shreffler WG, Masilamani M, Sampson HA. Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk tolerance. *J Allergy Clin Immunol*. 2013;131(1):180-186.e181-183.

960. Caubet JC, Nowak-Węgrzyn A, Moshier E, Godbold J, Wang J, Sampson HA. Utility of casein-specific IgE levels in predicting reactivity to baked milk. *J Allergy Clin Immunol*. 2013;131(1):222-224. e221-224.

961. Wang J, Lin J, Bardina L, et al. Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. *J Allergy Clin Immunol*. 2010;125(3):695-702. 702.e691-702.e696.

962. Wanich N, Nowak-Węgrzyn A, Sampson HA, Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. *J Allergy Clin Immunol*. 2009;123(4):789-794.e720.

963. Mack DP, Chan ES, Shaker M, et al. Novel Approaches to Food Allergy Management During COVID-19 Inspire Long-Term Change. *J Allergy Clin Immunol Pract*. 2020;8(9):2851-2857.

964. Ball HB, Luyt D. Home-based cow's milk reintroduction using a milk ladder in children less than 3 years old with IgE-mediated cow's milk allergy. *Clin Exp Allergy*. 2019;49(6):911-920.

965. Mac Mahon J, Hourihane JO, Byrne A. A virtual management approach to infant egg allergy developed in response to pandemic-imposed restrictions. *Clin Exp Allergy*. 2021;51:360-363.

966. Yonkof JR, Mikhail IJ, Prince BT, Stukus D. Delayed and Severe Reactions to Baked Egg and Baked Milk Challenges. *J Allergy Clin Immunol Pract*. 2021;9(1):283-289.e282.

967. Nowak-Węgrzyn A, Lawson K, Masilamani M, Kattan J, Bahnsen HT, Sampson HA. Increased Tolerance to Less Extensively Heat-Denatured (Baked) Milk Products in Milk-Allergic Children. *J Allergy Clin Immunol Pract*. 2018;6(2):486-495.e485.

968. D'Auria E, Salvatore S, Pozzi E, et al. Cow's Milk Allergy: Immunomodulation by Dietary Intervention. *Nutrients*. 2019;11(6).
928. Leoni C, Volpicella M, Dileo M, Gattulli BAR, Ceci LR. Chitinases as Food Allergens. *Molecules*. 2019;24(11).

929. Li MX, Hwang PM. Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. *Gene*. 2015;571(2):153-166.

930. Burmester T. Evolution and function of the insect hexamerins. *EJE*. 1999;96(3):213-225.

931. Rane AS, Joshi RS, Giri AP. Molecular determinant for specificity: Differential interaction of α-amylases with their proteinaceous inhibitors. *Biochim Biophys Acta Gen Subj*. 1864;2020(12):129703.

932. Barre A, Pichereaux C, Simplicien M, Burlet-Schiltz O, Benoist H, Rougé P. A Proteomic- and Bioinformatic-Based Identification of Specific Allergens from Edible Insects: Probes for Future Detection as Food Ingredients. *Foods*. 2021;10(2).

933. de Gier S, Verhoeckx K. Insect (food) allergy and allergens. *Mol Immunol*. 2018;100:82-106.

934. Broekman H, Verhoeckx KC, den Hartog Jager CF, et al. Majority of shrimp-allergic patients are allergic to mealworm. *J Allergy Clin Immunol*. 2016;137(4):1261-1263.

935. Broekman H, Knulst AC, de Jong G, et al. Is mealworm or shrimp allergy indicative for food allergy to insects? *Mol Nutr Food Res*. 2017;61(9).

936. Nebbia S, Lamberti C, Giorgis V, et al. The cockroach allergen-like protein is involved in primary respiratory and food allergy to yellow mealworm (Tenebrio molitor). *Clin Exp Allergy*. 2019;49(10):1379-1382.

937. Bose U, Broadbent JA, Juhász A, et al. Protein extraction protocols for optimal proteome measurement and arginine kinase quantitation from cricket Acheta domesticus for food safety assessment. *Food Chem*. 2021;348:129110.

938. Broekman H, Knulst A, den Hartog JS, et al. Effect of thermal processing on mealworm allergenicity. *Mol Nutr Food Res*. 2015;59(9):1855-1864.

939. Pali-Schöll I, Meinlschmidt P, Larenas-Linnemann D, et al. Edible insects: Cross-recognition of IgE from crustacean- and house dust mite allergic patients, and reduction of allergenicity by food processing. *World Allergy Organ J*. 2019;12(1):100006.

940. Mankouri F, Sereme Y, Michel M, et al. Immediate Hypersensitivity to Mealworm and Cricket: Beyond Shrimp and House Dust Mite Cross-Reactivity. *J Investig Allergol Clin Immunol*. 2021;32(1):64-66.

941. Kung SJ, Fenemore B, Potter PC. Anaphylaxis to Mopane worms (*Imbrasia belina*). *Ann Allergy Asthma Immunol*. 2011;106:538-540.

942. Hustinx-Broekman HCHP, Allergenic risks of mealworm and other insects, in Universiteit Utrecht. doctoral thesis 201. Allergenic risks of mealworm and other insects, in Universiteit Utrecht. doctoral thesis 2017, Utrecht. https://dspace.library.uu.nl/handle/1874/349295.

943. Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. *J Allergy Clin Immunol*. 2010;126(6):1105-1118.

944. Schoemaker AA, Sprikkelman AB, Grimshaw KE, et al. Incidence and natural history of challenge-proven cow's milk allergy in European children-EuroPrevall birth cohort. *Allergy*. 2015;70(8):963-972.

945. Restani P, Beretta B, Fiocchi A, Ballabio C, Galli CL. Cross-reactivity between mammalian proteins. *Ann Allergy Asthma Immunol*. 2002;89(6 Suppl 1):11-15.

946. Tsabouri S, Douros K, Priftis KN. Cow's milk allergenicity. *Endoc Metab Immune Disord Drug Targets*. 2014;14(1):16-26.

947. Fiocchi A, Dahdah L, Albarini M, Martelli A. Cow's milk allergy in children and adults. *Chem Immunol Allergy*. 2015;101:114-123.

948. Bloom KA, Huang FR, Bencharitiwong R, et al. Effect of heat treatment on milk and egg proteins allergenicity. *Pediatr Allergy Immunol*. 2014;25(8):740-746.

949. Bijl E, van Valenberg HJ, Huppertz T, van Hooijdonk AC. Protein, casein, and micellar salts in milk: current content and historical perspectives. *J Dairy Sci*. 2013;96(9):5455-5464.

950. de Kruif CG, Huppertz T, Urban VS, Petukhov AV. Casein micelles and their internal structure. *Adv Colloid Interface Sci*. 2012;171-172:36-52.

951. Werfel SJ, Cooke SK, Sampson HA. Clinical reactivity to beef in children allergic to cow's milk. *J Allergy Clin Immunol*. 1997;99(3):293-300.

952. Restani P, Ballabio C, Tripodi S, Fiocchi A. Meat allergy. *Curr Opin Allergy Clin Immunol*. 2009;9(3):265-269.

953. Restani P, Ballabio C, Di Lorenzo C, Tripodi S, Fiocchi A. Molecular aspects of milk allergens and their role in clinical events. *Anal Bioanal Chem*. 2009;395(1):47-56.

954. Vicente-Serrano J, Caballero ML, Rodríguez-Pérez R, et al. Sensitization to serum albumins in children allergic to cow's milk and epithelia. *Pediatr Allergy Immunol*. 2007;18(6):503-507.

955. Chatchatee P, Järvinen KM, Bardina L, Vila L, Beyer K, Sampson HA. Identification of IgE and IgG binding epitopes on beta- and kappa-casein in cow's milk allergic patients. *Clin Exp Allergy*. 2001;31(8):1256-1262.

956. Chatchatee P, Järvinen KM, Bardina L, Beyer K, Sampson HA. Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow's milk allergy. *J Allergy Clin Immunol*. 2001;107(2):379-383.

957. Lorenz AR, Scheurer S, Vieths S. Food allergens: molecular and immunological aspects, allergen databases and cross-reactivity. *Chem Immunol Allergy*. 2015;101:18-29.

958. Kim JS, Nowak-Węgrzyn A, Sicherer SH, Noone S, Moshier EL, Sampson HA. Dietary baked milk accelerates the resolution of cow's milk allergy in children. *J Allergy Clin Immunol*. 2011;128(1):125-131.e122.

959. Ford LS, Bloom KA, Nowak-Węgrzyn AH, Shreffler WG, Masilamani M, Sampson HA. Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk tolerance. *J Allergy Clin Immunol*. 2013;131(1):180-186.e181-183.

960. Caubet JC, Nowak-Węgrzyn A, Moshier E, Godbold J, Wang J, Sampson HA. Utility of casein-specific IgE levels in predicting reactivity to baked milk. *J Allergy Clin Immunol*. 2013;131(1):222-224. e221-224.

961. Wang J, Lin J, Bardina L, et al. Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. *J Allergy Clin Immunol*. 2010;125(3):695-702. 702.e691-702.e696.

962. Wanich N, Nowak-Węgrzyn A, Sampson HA, Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. *J Allergy Clin Immunol*. 2009;123(4):789-794.e720.

963. Mack DP, Chan ES, Shaker M, et al. Novel Approaches to Food Allergy Management During COVID-19 Inspire Long-Term Change. *J Allergy Clin Immunol Pract*. 2020;8(9):2851-2857.

964. Ball HB, Luyt D. Home-based cow's milk reintroduction using a milk ladder in children less than 3 years old with IgE-mediated cow's milk allergy. *Clin Exp Allergy*. 2019;49(6):911-920.

965. Mac Mahon J, Hourihane JO, Byrne A. A virtual management approach to infant egg allergy developed in response to pandemic-imposed restrictions. *Clin Exp Allergy*. 2021;51:360-363.

966. Yonkof JR, Mikhail IJ, Prince BT, Stukus D. Delayed and Severe Reactions to Baked Egg and Baked Milk Challenges. *J Allergy Clin Immunol Pract*. 2021;9(1):283-289.e282.

967. Nowak-Węgrzyn A, Lawson K, Masilamani M, Kattan J, Bahnsen HT, Sampson HA. Increased Tolerance to Less Extensively Heat-Denatured (Baked) Milk Products in Milk-Allergic Children. *J Allergy Clin Immunol Pract*. 2018;6(2):486-495.e485.

968. D'Auria E, Salvatore S, Pozzi E, et al. Cow's Milk Allergy: Immunomodulation by Dietary Intervention. *Nutrients*. 2019;11(6).
969. Groetch M, Nowak-Wegrzyn A. Practical approach to nutrition and dietary intervention in pediatric food allergy. *Pediatr Allergy Immunol.* 2013;24(3):212-221.

970. Dupont C, Kalach N, Soulaines P, Legoué-Morillon S, Piloquet H, Benhamou PH. Cow's milk epicutaneous immunotherapy in children: a pilot trial of safety, acceptability, and impact on allergic reactivity. *J Allergy Clin Immunol.* 2010;125:1165-1167.

971. Shek LP, Soderstrom L, Ahlstedt S, Beyer K, Sampson HA. Determination of food specific IgE levels over time can predict the development of tolerance in cow's milk and hen's egg allergy. *J Allergy Clin Immunol.* 2004;114(2):387-391.

972. Skripak JM, Matsui EC, Mudd K, Wood RA. The natural history of IgE-mediated cow's milk allergy. *J Allergy Clin Immunol.* 2007;120(5):1172-1177.

973. Leung J, Hundal NV, Katz AJ, et al. Tolerance of baked milk in patients with cow's milk-mediated eosinophilic esophagitis. *J Allergy Clin Immunol.* 2013;132(5):1215-1216.e1211.

974. Martelli A, De Chiara A, Corvo M, Restani P, Fiocchi A. Beef allergy in children with cow's milk allergy; cow's milk allergy in children with beef allergy. *Ann Allergy Asthma Immunol.* 2002;89(6 Suppl 1):38-43.

975. Commins SP, Satinover SM, Hosen J, et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. *J Allergy Clin Immunol.* 2009;123(2):426-433. doi:10.1016/j.jaci.2008.10.052

976. Savage J, Johns CB. Food allergy: epidemiology and natural history. *Immunol Allergy Clin North Am.* 2015;35(1):45-59.

977. Savage J, Sicherer S, Wood R. The Natural History of Food Allergy. *J Allergy Clin Immunol Pract.* 2016;4(2):196-203. quiz 204.

978. Abrams EM, Sicherer SH. Cow's milk allergy prevention. *Ann Allergy Asthma Immunol.* 2021;127(1):36-41.

979. Wood RA, Sicherer SH, Vickery BP, et al. The natural history of milk allergy in an observational cohort. *J Allergy Clin Immunol.* 2013;131(3):805-812.

980. Høst A, Halken S, Jacobsen HP, Christensen AE, Herskind AM, Plesner K. Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood. *Pediatr Allergy Immunol.* 2002;13(s15):23-28.

981. Lam HY, van Hoffen E, Michelsen A, et al. Cow's milk allergy in adults is rare but severe: both casein and whey proteins are involved. *Clin Exp Allergy.* 2008;38(6):995-1002.

982. Halken S, Muraro A, de Silva D, et al. EAACI guideline: Preventing the development of food allergy in infants and young children (2020 update). *Pediatr Allergy Immunol.* 2021;32(5):843-858.

983. Sakihara T, Otsuji K, Arakaki Y, Hamada K, Sugiura S, Ito K. Randomized trial of early infant formula introduction to prevent cow's milk allergy. *J Allergy Clin Immunol.* 2021;147(1):224-232.e228.

984. Albin S, Nowak-Wegrzyn A. Potential treatments for food allergy. *Immunol Allergy Clin North Am.* 2015;35(1):77-100.

985. Pajno GBF-RM, Arasi S, et al. EAACI Allergen Immunotherapy Guidelines Group. EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy. *Allergy.* 2018;73(4):799-815. doi:10.1111/all.13319

986. Escudero C, Quirce S, Fernández-Nieto M, Miguel J, Cuesta J, Sastre J. Egg white proteins as inhalant allergens associated with baker's asthma. *Allergy.* 2003;58(7):616-620.

987. Brough HA, Santos AF, Makinson K, et al. Peanut protein in household dust is related to household peanut consumption and is biologically active. *J Allergy Clin Immunol.* 2013;132(3):630-638.

988. Ballmer-Weber BK, Fernandez-Rivas M, Beyer K, et al. How much is too much? Threshold dose distributions for 5 food allergens. *J Allergy Clin Immunol.* 2015;135(4):964-971.

989. Logan K, Du Toit G, Giovannini M, Turcanu V, Lack G. Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance. *Annu Rev Cell Dev Biol.* 2020;36:511-528.

990. Martorell Aragonés A, Boné Calvo J, CGA M, Nevot Falcó S, MPM A. Allergy to egg proteins. *Allergol Immunopathol (Madr).* 2001;29(2):84-95.

991. Cooke SK, Sampson HA. Allergenic properties of ovomucoid in man. *J Immunol.* 1997;159(4):2026-2032.

992. Mine Y, Yang M. Recent advances in the understanding of egg allergens: basic, industrial, and clinical perspectives. *J Agric Food Chem.* 2008;56(13):4874-4900.

993. Urisu A, Ando H, Morita Y, et al. Allergenic activity of heated and ovomucoid-depleted egg white. *J Allergy Clin Immunol.* 1997;100(2):171-176.

994. Eigenmann PA. Anaphylactic reactions to raw eggs after negative challenges with cooked eggs. *J Allergy Clin Immunol.* 2000;105(3):587-588.

995. Calvani M, Arasi S, Bianchi A, et al. Is it possible to make a diagnosis of raw, heated, and baked egg allergy in children using cutoffs? A systematic review. *Pediatr Allergy Immunol.* 2015;26(6):509-521.

996. Benhamou AH, Caubet JC, Eigenmann PA, et al. State of the art and new horizons in the diagnosis and management of egg allergy. *Allergy.* 2010;65(3):283-289.

997. Eigenmann PA. Are specific immunoglobulin E titres reliable for prediction of food allergy? *Clin Exp Allergy.* 2005;35:247-249.

998. Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. *J Allergy Clin Immunol.* 2001;107(5):891-896.

999. Boyano Martínez T, García-Ara C, Díaz-Pena JM, Muñoz FM, García Sánchez G, Esteban MM. Validity of specific IgE antibodies in children with egg allergy. *Clin Exp Allergy.* 2001;31(9):1464-1469.

1000. Celik-Bilgili S, Mehl A, Verstege A, et al. The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges. *Clin Exp Allergy.* 2005;35(3):268-273.

1001. Benhamou AH, Zamora SA, Eigenmann PA. Correlation between specific immunoglobulin E levels and the severity of reactions in egg allergic patients. *Pediatr Allergy Immunol.* 2008;19(2):173-179.

1002. Ando H, Movérare R, Kondo Y, et al. Utility of ovomucoid-specific IgE concentrations in predicting symptomatic egg allergy. *J Allergy Clin Immunol.* 2008;122(3):583-588.

1003. Benhamou Senouf AH, Borres MP, Eigenmann PA. Native and denatured egg white protein IgE tests discriminate hen's egg allergic from egg-tolerant children. *Pediatr Allergy Immunol.* 2015;26(1):12-17.

1004. Sirin Kose S, Asilsoy S, Uzuner N, Karaman O, Anal O. Outcomes of Baked Milk and Egg Challenge in Cow's Milk and Hen's Egg Allergy: Can Tolerance Be Predicted with Allergen-Specific IgE and Prick-to-Prick Test? *Int Arch Allergy Immunol.* 2019;180(4):264-273.

1005. Dang TD, Peters RL, Koplin JJ, et al. Egg allergen specific IgE diversity predicts resolution of egg allergy in the population cohort HealthNuts. *Allergy.* 2019;74(2):318-326.

1006. Gradman J, Mortz CG, Eller E, Bindslev-Jensen C. Relationship between specific IgE to egg components and natural history of egg allergy in Danish children. *Pediatr Allergy Immunol.* 2016;27(8):825-830.

1007. Sicherer SH, Wood RA, Vickery BP, et al. The natural history of egg allergy in an observational cohort. *J Allergy Clin Immunol.* 2014;133(2):492-499.

1008. Pérez-Quintero O, Martínez-Azcona O, Balboa V, Vila L. Daily baked egg intake may accelerate the development of tolerance to raw egg in egg-allergic children. *Eur J Pediatr.* 2020;179(4):679-682.

1009. Kuehn A, Scheuermann T, Hilger C, Hentges F. Important variations in parvalbumin content in common fish species: a factor possibly contributing to variable allergenicity. *Int Arch Allergy Immunol.* 2010;153(4):359-366.

1010. Ruethers T, Taki AC, Karnaneedi S, et al. Expanding the allergen repertoire of salmon and catfish. *Allergy.* 2021;76(5):1443-1453.
969. Groetch M, Nowak-Wegrzyn A. Practical approach to nutrition and dietary intervention in pediatric food allergy. *Pediatr Allergy Immunol.* 2013;24(3):212-221.

970. Dupont C, Kalach N, Soulaines P, Legoué-Morillon S, Piloquet H, Benhamou PH. Cow's milk epicutaneous immunotherapy in children: a pilot trial of safety, acceptability, and impact on allergic reactivity. *J Allergy Clin Immunol.* 2010;125:1165-1167.

971. Shek LP, Soderstrom L, Ahlstedt S, Beyer K, Sampson HA. Determination of food specific IgE levels over time can predict the development of tolerance in cow's milk and hen's egg allergy. *J Allergy Clin Immunol.* 2004;114(2):387-391.

972. Skripak JM, Matsui EC, Mudd K, Wood RA. The natural history of IgE-mediated cow's milk allergy. *J Allergy Clin Immunol.* 2007;120(5):1172-1177.

973. Leung J, Hundal NV, Katz AJ, et al. Tolerance of baked milk in patients with cow's milk-mediated eosinophilic esophagitis. *J Allergy Clin Immunol.* 2013;132(5):1215-1216.e1211.

974. Martelli A, De Chiara A, Corvo M, Restani P, Fiocchi A. Beef allergy in children with cow's milk allergy; cow's milk allergy in children with beef allergy. *Ann Allergy Asthma Immunol.* 2002;89(6 Suppl 1):38-43.

975. Commins SP, Satinover SM, Hosen J, et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. *J Allergy Clin Immunol.* 2009;123(2):426-433. doi:10.1016/j.jaci.2008.10.052

976. Savage J, Johns CB. Food allergy: epidemiology and natural history. *Immunol Allergy Clin North Am.* 2015;35(1):45-59.

977. Savage J, Sicherer S, Wood R. The Natural History of Food Allergy. *J Allergy Clin Immunol Pract.* 2016;4(2):196-203. quiz 204.

978. Abrams EM, Sicherer SH. Cow's milk allergy prevention. *Ann Allergy Asthma Immunol.* 2021;127(1):36-41.

979. Wood RA, Sicherer SH, Vickery BP, et al. The natural history of milk allergy in an observational cohort. *J Allergy Clin Immunol.* 2013;131(3):805-812.

980. Høst A, Halken S, Jacobsen HP, Christensen AE, Herskind AM, Plesner K. Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood. *Pediatr Allergy Immunol.* 2002;13(s15):23-28.

981. Lam HY, van Hoffen E, Michelsen A, et al. Cow's milk allergy in adults is rare but severe: both casein and whey proteins are involved. *Clin Exp Allergy.* 2008;38(6):995-1002.

982. Halken S, Muraro A, de Silva D, et al. EAACI guideline: Preventing the development of food allergy in infants and young children (2020 update). *Pediatr Allergy Immunol.* 2021;32(5):843-858.

983. Sakihara T, Otsuji K, Arakaki Y, Hamada K, Sugiura S, Ito K. Randomized trial of early infant formula introduction to prevent cow's milk allergy. *J Allergy Clin Immunol.* 2021;147(1):224-232.e228.

984. Albin S, Nowak-Wegrzyn A. Potential treatments for food allergy. *Immunol Allergy Clin North Am.* 2015;35(1):77-100.

985. Pajno GBF-RM, Arasi S, et al. EAACI Allergen Immunotherapy Guidelines Group. EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy. *Allergy.* 2018;73(4):799-815. doi:10.1111/all.13319

986. Escudero C, Quirce S, Fernández-Nieto M, Miguel J, Cuesta J, Sastre J. Egg white proteins as inhalant allergens associated with baker's asthma. *Allergy.* 2003;58(7):616-620.

987. Brough HA, Santos AF, Makinson K, et al. Peanut protein in household dust is related to household peanut consumption and is biologically active. *J Allergy Clin Immunol.* 2013;132(3):630-638.

988. Ballmer-Weber BK, Fernandez-Rivas M, Beyer K, et al. How much is too much? Threshold dose distributions for 5 food allergens. *J Allergy Clin Immunol.* 2015;135(4):964-971.

989. Logan K, Du Toit G, Giovannini M, Turcanu V, Lack G. Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance. *Annu Rev Cell Dev Biol.* 2020;36:511-528.

990. Martorell Aragonés A, Boné Calvo J, CGA M, Nevot Falcó S, MPM A. Allergy to egg proteins. *Allergol Immunopathol (Madr).* 2001;29(2):84-95.

991. Cooke SK, Sampson HA. Allergenic properties of ovomucoid in man. *J Immunol.* 1997;159(4):2026-2032.

992. Mine Y, Yang M. Recent advances in the understanding of egg allergens: basic, industrial, and clinical perspectives. *J Agric Food Chem.* 2008;56(13):4874-4900.

993. Urisu A, Ando H, Morita Y, et al. Allergenic activity of heated and ovomucoid-depleted egg white. *J Allergy Clin Immunol.* 1997;100(2):171-176.

994. Eigenmann PA. Anaphylactic reactions to raw eggs after negative challenges with cooked eggs. *J Allergy Clin Immunol.* 2000;105(3):587-588.

995. Calvani M, Arasi S, Bianchi A, et al. Is it possible to make a diagnosis of raw, heated, and baked egg allergy in children using cutoffs? A systematic review. *Pediatr Allergy Immunol.* 2015;26(6):509-521.

996. Benhamou AH, Caubet JC, Eigenmann PA, et al. State of the art and new horizons in the diagnosis and management of egg allergy. *Allergy.* 2010;65(3):283-289.

997. Eigenmann PA. Are specific immunoglobulin E titres reliable for prediction of food allergy? *Clin Exp Allergy.* 2005;35:247-249.

998. Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. *J Allergy Clin Immunol.* 2001;107(5):891-896.

999. Boyano Martínez T, García-Ara C, Díaz-Pena JM, Muñoz FM, García Sánchez G, Esteban MM. Validity of specific IgE antibodies in children with egg allergy. *Clin Exp Allergy.* 2001;31(9):1464-1469.

1000. Celik-Bilgili S, Mehl A, Verstege A, et al. The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges. *Clin Exp Allergy.* 2005;35(3):268-273.

1001. Benhamou AH, Zamora SA, Eigenmann PA. Correlation between specific immunoglobulin E levels and the severity of reactions in egg allergic patients. *Pediatr Allergy Immunol.* 2008;19(2):173-179.

1002. Ando H, Movérare R, Kondo Y, et al. Utility of ovomucoid-specific IgE concentrations in predicting symptomatic egg allergy. *J Allergy Clin Immunol.* 2008;122(3):583-588.

1003. Benhamou Senouf AH, Borres MP, Eigenmann PA. Native and denatured egg white protein IgE tests discriminate hen's egg allergic from egg-tolerant children. *Pediatr Allergy Immunol.* 2015;26(1):12-17.

1004. Sirin Kose S, Asilsoy S, Uzuner N, Karaman O, Anal O. Outcomes of Baked Milk and Egg Challenge in Cow's Milk and Hen's Egg Allergy: Can Tolerance Be Predicted with Allergen-Specific IgE and Prick-to-Prick Test? *Int Arch Allergy Immunol.* 2019;180(4):264-273.

1005. Dang TD, Peters RL, Koplin JJ, et al. Egg allergen specific IgE diversity predicts resolution of egg allergy in the population cohort HealthNuts. *Allergy.* 2019;74(2):318-326.

1006. Gradman J, Mortz CG, Eller E, Bindslev-Jensen C. Relationship between specific IgE to egg components and natural history of egg allergy in Danish children. *Pediatr Allergy Immunol.* 2016;27(8):825-830.

1007. Sicherer SH, Wood RA, Vickery BP, et al. The natural history of egg allergy in an observational cohort. *J Allergy Clin Immunol.* 2014;133(2):492-499.

1008. Pérez-Quintero O, Martinez-Azcona O, Balboa V, Vila L. Daily baked egg intake may accelerate the development of tolerance to raw egg in egg-allergic children. *Eur J Pediatr.* 2020;179(4):679-682.

1009. Kuehn A, Scheuermann T, Hilger C, Hentges F. Important variations in parvalbumin content in common fish species: a factor possibly contributing to variable allergenicity. *Int Arch Allergy Immunol.* 2010;153(4):359-366.

1010. Ruethers T, Taki AC, Karnaneedi S, et al. Expanding the allergen repertoire of salmon and catfish. *Allergy.* 2021;76(5):1443-1453.
1011. Hanaoka K, Takahagi S, Ishii K, et al. Type-I-hypersensitivity to 15 kDa, 28 kDa and 54 kDa proteins in vitellogenin specific to Gadus chalcogrammus roe. *Allergol Int.* 2020;69(2):253-260.

1012. Kalic T, Kamath SD, Ruethers T, et al. Collagen-An Important Fish Allergen for Improved Diagnosis. *J Allergy Clin Immunol Pract.* 2020;8(9):3084-3092.e3010.

1013. Douglas JD, McSharry C, Blaikie L, Morrow T, Miles S, Franklin D. Occupational asthma caused by automated salmon processing. *Lancet.* 1995;346(8977):737-740.

1014. Mason HJ, Carder M, Money A, et al. Occupational Asthma and Its Causation in the UK Seafood Processing Industry. *Ann Work Expo Health.* 2020;64(8):817-825.

1015. Ruethers T, Taki AC, Johnston EB, et al. Seafood allergy: A comprehensive review of fish and shellfish allergens. *Mol Immunol.* 2018;100:28-57.

1016. Peixoto S, Monteiro T, Carvalho M, et al. Vertebrate Tropomyosin as an Allergen. *J Investig Allergol Clin Immunol.* 2018;28(1):51-53.

1017. Aibinu IE, Smooker PM, Lopata AL. Anisakis Nematodes in Fish and Shellfish- from infection to allergies. *Int J Parasitol Parasites Wildl.* 2019;9:384-393.

1018. Davis CM, Gupta RS, Aktas ON, Diaz V, Kamath SD, Lopata AL. Clinical Management of Seafood Allergy. *J Allergy Clin Immunol Pract.* 2020;8(1):37-44.

1019. Debenedetti AL, Madrid E, Trelis M, et al. Prevalence and risk of anisakid larvae in fresh fish frequently consumed in Spain: an overview. *Fishes.* 2019;4:1-16.

1020. Lanfranchi AL, Sardella NH. Anisakids survival after microwaving, freezing and salting fish from Argentina. *Food Sci Technol Res.* 2010;16:499-504.

1021. Audicana MT, Ansotegui IJ, de Corres LF, Kennedy MW. Anisakis simplex: dangerous-dead and alive? *Trends Parasitol.* 2002;18(1):20-25.

1022. Dickel H, Kuehn A, Dickel B, et al. Assessment of the effects of a work-related allergy to seafood on the reduction of earning capacity in the context of BK No. 5101. *Allergol Select.* 2021;5:33-44.

1023. Bonlokke JH, Bang B, Aasmoe L, et al. Exposures and Health Effects of Bioaerosols in Seafood Processing Workers - a Position Statement. *J Agromedicine.* 2019;24(4):441-448.

1024. Kuehn A, Hilger C, Lehners-Weber C, et al. Identification of enolases and aldolases as important fish allergens in cod, salmon and tuna: component resolved diagnosis using parvalbumin and the new allergens. *Clin Exp Allergy.* 2013;43(7):811-822.

1025. Kuehn A, Hilger C, Hentges F. Anaphylaxis provoked by ingestion of marshmallows containing fish gelatin. *J Allergy Clin Immunol.* 2009;123:708-709.

1026. Ueno R, Takaoka Y, Shimojo N, et al. A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen. *Asia Pac Allergy.* 2020;10:e35.

1027. Fæste CK, Jonscher KR, Dooper MM, et al. Characterisation of potential novel allergens in the fish parasite Anisakis simplex. *EuPA Open Proteom.* 2014;4:140-155.

1028. Armentia A, Santos J, Serrano Z, et al. Molecular diagnosis of allergy to Anisakis simplex and Gymnorhynchus gigas fish parasites. *Allergol Immunopathol (Madr).* 2017;45(5):463-472.

1029. González-Fernández J, Rivas L, Luque-Ortega JR, et al. Recombinant vs native Anisakis haemoglobin (Ani s 13): Its appraisal as a new gold standard for the diagnosis of allergy. *Exp Parasitol.* 2017;181:119-129.

1030. de Las Vecillas L, Bartolomé-Zavala B, Asensio E, et al. Hypersensitivity to Chironomid Larvae in a Nonatopic Patient: Safe Diagnosis Tools to Identify a Potent Allergen. *J Investig Allergol Clin Immunol.* 2018;28(4):259-260.

1031. Radauer C, Dublin M, Wagner S, Mari A, Breiteneder H. Allergens are distributed into few protein families and possess a restricted number of biochemical functions. *J Allergy Clin Immunol.* 2008;121(4):847-852.e847.

1032. Moonesinghe H, Mackenzie H, Venter C, et al. Prevalence of fish and shellfish allergy: A systematic review. *Ann Allergy Asthma Immunol.* 2016;117(3):264-272.e264.

1033. Lyons SA, Clausen M, Knulst AC, et al. Prevalence of Food Sensitization and Food Allergy in Children Across Europe. *J Allergy Clin Immunol Pract.* 2020;8(8):2736-2746.e2739.

1034. Lyons SA, Burney PGJ, Ballmer-Weber BK, et al. Food Allergy in Adults: Substantial Variation in Prevalence and Causative Foods Across Europe. *J Allergy Clin Immunol Pract.* 2019;7(6):1920-1928. e1911.

1035. Xepapadaki P, Christopoulou G, Stavroulakis G, et al. Natural History of IgE-Mediated Fish Allergy in Children. *J Allergy Clin Immunol Pract.* 2021;9(8):3147-3156.e3145.

1036. Sørensen M, Kuehn A, Mills ENC, et al. Cross-reactivity in fish allergy: A double-blind, placebo-controlled food-challenge trial. *J Allergy Clin Immunol.* 2017;140(4):1170-1172.

1037. Kuehn A, Fischer J, Hilger C, Sparla C, Biedermann T, Hentges F. Correlation of clinical monosensitivity to cod with specific IgE to enolase and aldolase. *Ann Allergy Asthma Immunol.* 2014;113(6):670-671.e672.

1038. Brusca I, Graci S, Barrale M, et al. Use of a comprehensive diagnostic algorithm for Anisakis allergy in a high seroprevalence Mediterranean setting. *Eur Ann Allergy Clin Immunol.* 2020;52(3):131-141.

1039. de las Vecillas L, Muñoz-Cacho P, López-Hoyos M, et al. Analysis of Ani s 7 and Ani s 1 allergens as biomarkers of sensitization and allergy severity in human anisakiasis. *Sci Rep.* 2020;10(1):11275.

1040. Cuéllar C, Daschner A, Valls A, et al. Ani s 1 and Ani s 7 recombinant allergens are able to differentiate distinct Anisakis simplex-associated allergic clinical disorders. *Arch Dermatol Res.* 2012;304(4):283-288.

1041. Daschner A, Fernández-Figares V, Rodero M, et al. Specific IgG4: possible role in the pathogenesis and a new marker in the diagnosis of Anisakis-associated allergic disease. *Scand J Immunol.* 2014;79(2):120-126.

1042. Sampson HA, Ho DG. Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. *J Allergy Clin Immunol.* 1997;100(4):444-451.

1043. Infante S, Pérez-Pallisé E, Skrabski F, et al. Poor prognosis of food protein-induced enterocolitis syndrome to fish. *Pediatr Allergy Immunol.* 2021;32(3):560-565.

1044. Mazzucco W, Raia DD, Marotta C, et al. Anisakis sensitisation in different population groups and public health impact: A systematic review. *PLoS One.* 2018;13(9):e0203671. Published 2018 Sep 20.

1045. Kuehn A, Codreanu-Morel F, Lehners-Weber C, et al. Cross-reactivity to fish and chicken meat - a new clinical syndrome. *Allergy.* 2016;71(12):1772-1781.

1046. Turner P, Ng I, Kemp A, Campbell D. Seafood allergy in children: a descriptive study. *Ann Allergy Asthma Immunol.* 2011;106(6):494-501.

1047. Chokshi NY, Maskatia Z, Miller S, Guffey D, Minard CG, Davis CM. Risk factors in pediatric shrimp allergy. *Allergy Asthma Proc.* 2015;36(4):65-71.

1048. Kamath SD, Rahman AM, Voskamp A, et al. Effect of heat processing on antibody reactivity to allergen variants and fragments of black tiger prawn: A comprehensive allergenomic approach. *Mol Nutr Food Res.* 2014;58(5):1144-1155.

1049. Koeberl M, Clarke D, Lopata AL. Next generation of food allergen quantification using mass spectrometric systems. *J Proteome Res.* 2014;13(8):3499-3509.

1050. Kamath SD, Thomassen MR, Saptarshi SR, et al. Molecular and immunological approaches in quantifying the air-borne food allergen tropomyosin in crab processing facilities. *Int J Hyg Environ Health.* 2014;217(7):740-750.

1051. Baynova K, Leguísamo S, Bartolomé B, Prados M. Occupational allergic contact urticaria caused by the crustaceans Palaemon
1011. Hanaoka K, Takahagi S, Ishii K, et al. Type-I-hypersensitivity to 15 kDa, 28 kDa and 54 kDa proteins in vitellogenin specific to Gadus chalcogrammus roe. *Allergol Int.* 2020;69(2):253-260.

1012. Kalic T, Kamath SD, Ruethers T, et al. Collagen-An Important Fish Allergen for Improved Diagnosis. *J Allergy Clin Immunol Pract.* 2020;8(9):3084-3092.e3010.

1013. Douglas JD, McSharry C, Blaikie L, Morrow T, Miles S, Franklin D. Occupational asthma caused by automated salmon processing. *Lancet.* 1995;346(8977):737-740.

1014. Mason HJ, Carder M, Money A, et al. Occupational Asthma and Its Causation in the UK Seafood Processing Industry. *Ann Work Expo Health.* 2020;64(8):817-825.

1015. Ruethers T, Taki AC, Johnston EB, et al. Seafood allergy: A comprehensive review of fish and shellfish allergens. *Mol Immunol.* 2018;100:28-57.

1016. Peixoto S, Monteiro T, Carvalho M, et al. Vertebrate Tropomyosin as an Allergen. *J Investig Allergol Clin Immunol.* 2018;28(1):51-53.

1017. Aibinu IE, Smooker PM, Lopata AL. Anisakis Nematodes in Fish and Shellfish- from infection to allergies. *Int J Parasitol Parasites Wildl.* 2019;9:384-393.

1018. Davis CM, Gupta RS, Aktas ON, Diaz V, Kamath SD, Lopata AL. Clinical Management of Seafood Allergy. *J Allergy Clin Immunol Pract.* 2020;8(1):37-44.

1019. Debenedetti AL, Madrid E, Trelis M, et al. Prevalence and risk of anisakid larvae in fresh fish frequently consumed in Spain: an overview. *Fishes.* 2019;4:1-16.

1020. Lanfranchi AL, Sardella NH. Anisakids survival after microwaving, freezing and salting fish from Argentina. *Food Sci Technol Res.* 2010;16:499-504.

1021. Audicana MT, Ansotegui IJ, de Corres LF, Kennedy MW. Anisakis simplex: dangerous-dead and alive? *Trends Parasitol.* 2002;18(1):20-25.

1022. Dickel H, Kuehn A, Dickel B, et al. Assessment of the effects of a work-related allergy to seafood on the reduction of earning capacity in the context of BK No. 5101. *Allergol Select.* 2021;5:33-44.

1023. Bonlokke JH, Bang B, Aasmoe L, et al. Exposures and Health Effects of Bioaerosols in Seafood Processing Workers - a Position Statement. *J Agromedicine.* 2019;24(4):441-448.

1024. Kuehn A, Hilger C, Lehners-Weber C, et al. Identification of enolases and aldolases as important fish allergens in cod, salmon and tuna: component resolved diagnosis using parvalbumin and the new allergens. *Clin Exp Allergy.* 2013;43(7):811-822.

1025. Kuehn A, Hilger C, Hentges F. Anaphylaxis provoked by ingestion of marshmallows containing fish gelatin. *J Allergy Clin Immunol.* 2009;123:708-709.

1026. Ueno R, Takaoka Y, Shimojo N, et al. A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen. *Asia Pac Allergy.* 2020;10:e35.

1027. Fæste CK, Jonscher KR, Dooper MM, et al. Characterisation of potential novel allergens in the fish parasite Anisakis simplex. *EuPA Open Proteom.* 2014;4:140-155.

1028. Armentia A, Santos J, Serrano Z, et al. Molecular diagnosis of allergy to Anisakis simplex and Gymnorhynchus gigas fish parasites. *Allergol Immunopathol (Madr).* 2017;45(5):463-472.

1029. González-Fernández J, Rivas L, Luque-Ortega JR, et al. Recombinant vs native Anisakis haemoglobin (Ani s 13): Its appraisal as a new gold standard for the diagnosis of allergy. *Exp Parasitol.* 2017;181:119-129.

1030. de Las Vecillas L, Bartolomé-Zavala B, Asensio E, et al. Hypersensitivity to Chironomid Larvae in a Nonatopic Patient: Safe Diagnosis Tools to Identify a Potent Allergen. *J Investig Allergol Clin Immunol.* 2018;28(4):259-260.

1031. Radauer C, Dublin M, Wagner S, Mari A, Breiteneder H. Allergens are distributed into few protein families and possess a restricted number of biochemical functions. *J Allergy Clin Immunol.* 2008;121(4):847-852.e847.

1032. Moonesinghe H, Mackenzie H, Venter C, et al. Prevalence of fish and shellfish allergy: A systematic review. *Ann Allergy Asthma Immunol.* 2016;117(3):264-272.e264.

1033. Lyons SA, Clausen M, Knulst AC, et al. Prevalence of Food Sensitization and Food Allergy in Children Across Europe. *J Allergy Clin Immunol Pract.* 2020;8(8):2736-2746.e2739.

1034. Lyons SA, Burney PGJ, Ballmer-Weber BK, et al. Food Allergy in Adults: Substantial Variation in Prevalence and Causative Foods Across Europe. *J Allergy Clin Immunol Pract.* 2019;7(6):1920-1928. e1911.

1035. Xepapadaki P, Christopoulou G, Stavroulakis G, et al. Natural History of IgE-Mediated Fish Allergy in Children. *J Allergy Clin Immunol Pract.* 2021;9(8):3147-3156.e3145.

1036. Sørensen M, Kuehn A, Mills ENC, et al. Cross-reactivity in fish allergy: A double-blind, placebo-controlled food-challenge trial. *J Allergy Clin Immunol.* 2017;140(4):1170-1172.

1037. Kuehn A, Fischer J, Hilger C, Sparla C, Biedermann T, Hentges F. Correlation of clinical monosensitivity to cod with specific IgE to enolase and aldolase. *Ann Allergy Asthma Immunol.* 2014;113(6):670-671.e672.

1038. Brusca I, Graci S, Barrale M, et al. Use of a comprehensive diagnostic algorithm for Anisakis allergy in a high seroprevalence Mediterranean setting. *Eur Ann Allergy Clin Immunol.* 2020;52(3):131-141.

1039. de las Vecillas L, Muñoz-Cacho P, López-Hoyos M, et al. Analysis of Ani s 7 and Ani s 1 allergens as biomarkers of sensitization and allergy severity in human anisakiasis. *Sci Rep.* 2020;10(1):11275.

1040. Cuéllar C, Daschner A, Valls A, et al. Ani s 1 and Ani s 7 recombinant allergens are able to differentiate distinct Anisakis simplex-associated allergic clinical disorders. *Arch Dermatol Res.* 2012;304(4):283-288.

1041. Daschner A, Fernández-Figares V, Rodero M, et al. Specific IgG4: possible role in the pathogenesis and a new marker in the diagnosis of Anisakis-associated allergic disease. *Scand J Immunol.* 2014;79(2):120-126.

1042. Sampson HA, Ho DG. Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. *J Allergy Clin Immunol.* 1997;100(4):444-451.

1043. Infante S, Pérez-Pallisé E, Skrabski F, et al. Poor prognosis of food protein-induced enterocolitis syndrome to fish. *Pediatr Allergy Immunol.* 2021;32(3):560-565.

1044. Mazzucco W, Raia DD, Marotta C, et al. Anisakis sensitisation in different population groups and public health impact: A systematic review. *PLoS One.* 2018;13(9):e0203671. Published 2018 Sep 20.

1045. Kuehn A, Codreanu-Morel F, Lehners-Weber C, et al. Cross-reactivity to fish and chicken meat - a new clinical syndrome. *Allergy.* 2016;71(12):1772-1781.

1046. Turner P, Ng I, Kemp A, Campbell D. Seafood allergy in children: a descriptive study. *Ann Allergy Asthma Immunol.* 2011;106(6):494-501.

1047. Chokshi NY, Maskatia Z, Miller S, Guffey D, Minard CG, Davis CM. Risk factors in pediatric shrimp allergy. *Allergy Asthma Proc.* 2015;36(4):65-71.

1048. Kamath SD, Rahman AM, Voskamp A, et al. Effect of heat processing on antibody reactivity to allergen variants and fragments of black tiger prawn: A comprehensive allergenomic approach. *Mol Nutr Food Res.* 2014;58(5):1144-1155.

1049. Koeberl M, Clarke D, Lopata AL. Next generation of food allergen quantification using mass spectrometric systems. *J Proteome Res.* 2014;13(8):3499-3509.

1050. Kamath SD, Thomassen MR, Saptarshi SR, et al. Molecular and immunological approaches in quantifying the air-borne food allergen tropomyosin in crab processing facilities. *Int J Hyg Environ Health.* 2014;217(7):740-750.

1051. Baynova K, Leguísamo S, Bartolomé B, Prados M. Occupational allergic contact urticaria caused by the crustaceans Palaemon
serratus and Procambarus clarkii. Contact Dermatitis. 2015;73(1):53-54.

1052. Lopata AL, Jeebhay MF. Airborne seafood allergens as a cause of occupational allergy and asthma. *Curr Allergy Asthma Rep.* 2013;13(3):288-297.

1053. Calleja Algarra A, Aragón Miguel R, Ortiz de Frutos FJ, Tous Romero F. Hand Lesions After Contact With Shellfish: Beyond Patch Testing. *Actas Dermosifiliogr (Engl Ed).* 2021;112(3):274-275.

1054. Jeebhay MF, Moscato G, Bang BE, et al. Food processing and occupational respiratory allergy- An EAACI position paper. *Allergy*. 2019;74(10):1852-1871.

1055. Nieuwenhuizen NE, Lopata AL. Anisakis-a food-borne parasite that triggers allergic host defences. *Int J Parasitol.* 2013;43(12-13):1047-1057.

1056. Shanti KN, Martin BM, Nagpal S, Metcalfe DD, Rao PV. Identification of tropomyosin as the major shrimp allergen and characterization of its IgE-binding epitopes. *J Immunol.* 1993;151(10):5354-5363.

1057. Kamath SD, Scheiblhofer S, Johnson CM, et al. Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin. *Allergy*. 2020;75(11):2909-2919.

1058. Guillen D, Fiandor A, Del Pozo V, et al. Anaphylaxis caused by hemocyanin contained in shrimp cephalothorax. *Ann Allergy Asthma Immunol.* 2014;113(6):674-675.e672.

1059. Yang S, Huang H, Wang F, Aweya JJ, Zheng Z, Zhang Y. Prediction and characterization of a novel hemocyanin-derived antimicrobial peptide from shrimp Litopenaeus vannamei. *Amino Acids.* 2018;50(8):995-1005.

1060. Mendoza-Porras O, Kamath S, Harris JO, et al. Resolving hemocyanin isoform complexity in haemolymph of black tiger shrimp Penaeus monodon - implications in aquaculture, medicine and food safety. *J Proteomics.* 2020;218:103689.

1061. Nugraha R, Kamath SD, Johnston E, et al. Rapid and comprehensive discovery of unreported shellfish allergens using large-scale transcriptomic and proteomic resources. *J Allergy Clin Immunol.* 2018;141(4):1501-1504.e1508.

1062. Rona RJ, Keil T, Summers C, et al. The prevalence of food allergy: a meta-analysis. *J Allergy Clin Immunol.* 2007;120(3):638-646.

1063. Wang HT, Warren CM, Gupta RS, Davis CM. Prevalence and Characteristics of Shellfish Allergy in the Pediatric Population of the United States. *J Allergy Clin Immunol Pract.* 2020;8(4):1359-1370.e1352.

1064. Gámez C, Sánchez-García S, Ibáñez MD, et al. Tropomyosin IgE-positive results are a good predictor of shrimp allergy. *Allergy*. 2011;66(10):1375-1383.

1065. Yang AC, Arruda LK, Santos AB, et al. Measurement of IgE antibodies to shrimp tropomyosin is superior to skin prick testing with commercial extract and measurement of IgE to shrimp for predicting clinically relevant allergic reactions after shrimp ingestion. *J Allergy Clin Immunol.* 2010;125(4):872-878.

1066. Pascal MKS, Faber M. Diagnosis and management of shellfish allergy: current approach and future needs. *Curr Treat Options Allergy.* 2018;1-17. doi:10.1007/s40521-018-0186-0

1067. Wai CYY, Leung NYH, Leung ASY, Wong GWK, Leung TF. Seafood Allergy in Asia: Geographical Specificity and Beyond. *Front Allergy.* 2021;2:676903.

1068. Abramovitch JB, Kamath S, Varese N, et al. IgE Reactivity of Blue Swimmer Crab (Portunus pelagicus) Tropomyosin, Por p 1, and Other Allergens; Cross-Reactivity with Black Tiger Prawn and Effects of Heating. *PLoS One.* 2013;8(6):e67487.

1069. Vidal C, Bartolomé B, Rodríguez V, Armisén M, Linneberg A, González-Quintela A. Sensitization pattern of crustacean-allergic individuals can indicate allergy to molluscs. *Allergy*. 2015;70(11):1493-1496.

1070. Giuffrida MG, Villalta D, Mistrello G, Amato S, Asero R. Shrimp allergy beyond Tropomyosin in Italy: clinical relevance of Arginine

Kinase, Sarcoplasmic calcium binding protein and Hemocyanin. *Eur Ann Allergy Clin Immunol.* 2014;46(5):172-177.

1071. Thomassen MR, Kamath SD, Bang BE, et al. Occupational Allergic Sensitization Among Workers Processing King Crab (Paralithodes camtschaticus) and Edible Crab (Cancer pagurus) in Norway and Identification of Novel Putative Allergenic Proteins. *Front Allergy.* 2021;2:718824.

1072. Cox AL, Eigenmann PA, Sicherer SH. Clinical Relevance of Cross-Reactivity in Food Allergy. *J Allergy Clin Immunol Pract.* 2021;9(1):82-99.

1073. Wang J, Calatroni A, Visness CM, Sampson HA. Correlation of specific IgE to shrimp with cockroach and dust mite exposure and sensitization in an inner-city population. *J Allergy Clin Immunol.* 2011;128(4):834-837.

1074. Nowak-Wegrzyn A, Berin MC, Mehr S. Food Protein-Induced Enterocolitis Syndrome. *J Allergy Clin Immunol Pract.* 2020;8(1):24-35.

1075. Asaumi T, Yanagida N, Sato S, Shukuya A, Nishino M, Ebisawa M. Provocation tests for the diagnosis of food-dependent exercise-induced anaphylaxis. *Pediatr Allergy Immunol.* 2016;27(1):44-49.

1076. Caubet JC, Cianferoni A, Groetch M, Nowak-Wegrzyn A. Food protein-induced enterocolitis syndrome. *Clin Exp Allergy.* 2019;49(9):1178-1190.

1077. Warren CM, Aktas ON, Gupta RS, Davis CM. Prevalence and characteristics of adult shellfish allergy in the United States. *J Allergy Clin Immunol.* 2019;144(5):1435-1438.e1435.

1078. Morgan JE, O'Neil CE, Daul CB, Lehrer SB. Species-specific shrimp allergens: RAST and RAST-inhibition studies. *J Allergy Clin Immunol.* 1989;83(6):1112-1117.

1079. Jirapongsananuruk O, Sripramong C, Pacharn P, et al. Specific allergy to Penaeus monodon (seawater shrimp) or Macrobrachium rosenbergii (freshwater shrimp) in shrimp-allergic children. *Clin Exp Allergy.* 2008;38(6):1038-1047.

1080. Liu GY, Mei XJ, Hu MJ, et al. Analysis of the Allergenic Epitopes of Tropomyosin from Mud Crab Using Phage Display and Site-Directed Mutagenesis. *J Agric Food Chem.* 2018;66(34):9127-9137.

1081. Wong L, Tham EH, Lee BW. An update on shellfish allergy. *Curr Opin Allergy Clin Immunol.* 2019;19(3):236-242.

1082. Nugraha R, Kamath SD, Johnston E, Karnaneedi S, Ruethers T, Lopata AL. Conservation Analysis of B-Cell Allergen Epitopes to Predict Clinical Cross-Reactivity Between Shellfish and Inhalant Invertebrate Allergens. *Front Immunol.* 2019;10:2676.

1083. Ayuso R, Lehrer SB, Lopez M, et al. Identification of bovine IgG as a major cross-reactive vertebrate meat allergen. *Allergy*. 2000;55(4):348-354.

1084. Mahdavinia M, Tobin MC, Fierstein JL, et al. African American Children Are More Likely to Be Allergic to Shellfish and Finfish: Findings from FORWARD, a Multisite Cohort Study. *J Allergy Clin Immunol Pract.* 2021;9(7):2867-2872.e2861.

1085. Ayuso RS-GS, Lin J, et al. Greater epitope recognition of shrimp allergens by children than by adults suggests that shrimp sensitization decreases with age. *J Allergy Clin Immunol.* 2010;125(6):1286-1293.e3. doi:10.1016/j.jaci.2010.03.010

1086. Thalayasingam M, Gerez IF, Yap GC, et al. Clinical and immunochemical profiles of food challenge proven or anaphylactic shrimp allergy in tropical Singapore. *Clin Exp Allergy.* 2015;45(3):687-697.

1087. Teo SL, Gerez IF, Ang EY, Shek LP. Food-dependent exercise-induced anaphylaxis - a review of 5 cases. *Ann Acad Med Singapore.* 2009;38(10):905-909.

1088. Kandyil RM, Davis CM. Shellfish allergy in children. *Pediatr Allergy Immunol.* 2009;20(5):408-414. quiz 414.

1089. Fiocchi A, Restani P, Riva E. Beef allergy in children. *Nutrition.* 2000;16(6):454-457.