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							Issue
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<div>
											BIO Web Conf.
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<div><strong>Volume </strong>209, 2026				</div>
				
					                The 1<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> International Conference on Biological Technology and Engineering for Sustainable Nature (IC-BioTEStA 2025)
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					Article Number
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<td>03007</td>
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					Number of page(s)
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<td>9</td>
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<th>Section</th>
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<td>Biomedical and Pharmaceutical Sciences</td>
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<th>DOI</th>
<td></td>
<td>
<a href="https://doi.org/10.1051/bioconf/202620903007">
					https://doi.org/10.1051/bioconf/202620903007
				</a>
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<th>Published online</th>
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				09 January 2026
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## Correlation Between Estrogen Receptor Alpha and Progesterone Receptor Expression in Stromal Tissue and Tumor Size of Archived Fibroadenoma Mammae Specimens

Kemala Anita Isdiawan3, Aris Rosidah2 and Dini Sri Damayanti11

1 Department of Medicine, Faculty of Medicine, Universitas Islam Malang, Malang 65144, Indonesia. 2 Department of Medicine, Faculty of Medicine, Universitas Islam Malang, Malang 65144, Indonesia. 3 Department of Medicine, Faculty of Medicine, Universitas Islam Malang, Malang 65144, Indonesia.

1 Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Fibroadenoma of the Breast (FAM) is a benign fibroepithelial breast tumor influenced by estrogen and progesterone through their binding to Estrogen Receptor-a (ER-a) and Progesterone Receptor (PR). These receptors are thought to contribute to mammary tissue proliferation; however, the role of stromal ER-a and PR in determining tumor size remains unclear. This study aimed to analyze the correlation between stromal ER-a and PR expression and FAM tumor size using archived specimens from RSI UNISMA. An analytic observational study with a cross-sectional design was conducted on 24 archived FAM tissue samples, with tumor size obtained from medical records. ER-a and PR expression in stromal tissue were evaluated using immunohistochemistry and quantified with ImageJ software. Data were analyzed using Spearman correlation with p<0.05. Tumor sizes ranged from 2-10 cm, with a mean ER-a expression of 2.46% and PR expression of 5.58%. Spearman test showed no significant correlation between stromal ER-a or PR expression and tumor size (p>0.05), although ER-a and PR contributed 23% and 11% respectively to tumor size variation. In conclusion, stromal ER-a and PR expression were not significantly associated with FAM tumor size, likely due to their dominant expression in ductal epithelial rather than stromal tissue.

Key words: ER-a / Fibroadenoma Mammae / Tumor size / PR

© The Authors, published by EDP Sciences, 2026

This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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