# Correction: The hinge segment of human NADPH-cytochrome P450 reductase in conformational switching: the critical role of ionic strength

Diana Campelo, Thomas Lautier, Philippe Urban, Francisco Esteves, Sophie

Bozonnet, Gilles Truan, Michel Kranendonk

<figure><img src="image_1.png" /></figure>

## To cite this version:

Diana Campelo, Thomas Lautier, Philippe Urban, Francisco Esteves, Sophie Bozonnet, et al., Correction: The hinge segment of human NADPH-cytochrome P450 reductase in conformational switching: the critical role of ionic strength. Frontiers in Pharmacology, 2018, 9, 10.3389/fphar.2018.00175. [https://doi.org/10.3389/fphar.2018.00175](https://doi.org/10.3389/fphar.2018.00175)

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Submitted on 25 May 2020

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<figure><img src="image_2.png" /></figure>
# Correction: The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength

OPEN ACCESS

Edited and reviewed by:

Ulrich M. Zanger,
Dr. Margarete Fischer-Bosch Institut
für Klinische Pharmakologie (IKP),
Germany

*Correspondence:

Gilles Truan
gilles.truan@insa-toulouse.fr

Michel Kranendonk
michel.kranendonk@nms.unl.pt

**Specialty section:**

This article was submitted to
Pharmacogenetics and
Pharmacogenomics,
a section of the journal
Frontiers in Pharmacology

Received: 13 February 2018

Accepted: 16 February 2018

Published: 19 March 2018

**Citation:**

Campelo D, Lautier T, Urban P, Esteves F, Bozonnet S, Truan G and Kranendonk M (2018) Correction: The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength. *Front. Pharmacol.* 9:175. doi: 10.3389/fphar.2018.00175

Diana Campelo<fnref n="1" />†, Thomas Lautier²†, Philippe Urban², Francisco Esteves<fnref n="1" />, Sophie Bozonnet², Gilles Truan²* and Michel Kranendonk<fnref n="1" />*

**Keywords:** diflavin reductase, protein dynamics, multidomain proteins, conformational exchange, electron transfer, protein-protein interaction

## A correction on

### The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength

by Campelo, D., Lautier, T., Urban, P., Esteves, F., Bozonnet, S., Truan, G., et al. (2017). *Front. Pharmacol.* 8:755. doi: 10.3389/fphar.2017.00755

There is a mistake in the values of the y axis of **Figure 1**. The correct version of **Figure 1** appears below. The authors apologize for the mistake. This error does not change the scientific conclusions of the article in any way.

The original article has been updated.

**Conflict of Interest Statement:** The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2018 Campelo, Lautier, Urban, Esteves, Bozonnet, Truan and Kranendonk. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

<footnote>† These authors have contributed
equally to this work.</footnote>

<footnote n="1">¹ Center for Toxicogenomics and Human Health (ToxOmics), Genetics, Oncology and Human Toxicology, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal, ² LISBP, Université de Toulouse, CNRS, INRA, INSA, Toulouse, France</footnote>
<figure><img src="image_3.png" /><figcaption>**FIGURE 1** | Variation of *k*<sub>obs</sub> in function of the ionic strength. The activity of the soluble, WT form of human CPR was assayed with various acceptors, namely cytochrome *c* (**A**), DCPIP (**B**) or ferricyanide (**C**).</figcaption></figure>