# From Sugars to Nutritional Products – Active Ingredients

Werner Bonrath, Hans Kroon, Ulla Létinois, Maurus Marty*, Oliver May, Marc-André Müller, Jan Schütz, and Bettina Wüstenberg

In this article (CHIMIA 2021, 75, 757–765), Scheme 13 and the paragraph describing it on page 764:

Another access to (all-*rac*)-α-tocopherol from renewable furans uses long chain alkynes such as a C₂₂-dienyne (Scheme 13).[93] The side-chain is constructed starting from phytol which can be oxidized to phytal. After addition of acetylene and dehydration, a C₂₂-dienyne is obtained and easily converted with 2,5-DMF to the desired phenol. Acid catalyzed ring closure to the corresponding chromane, then oxidation to the quinone, followed by hydrogenation gave access to (all-*rac*)-β-tocopherol.

need to be replaced by the following text and the scheme depicted below:

Another access to (all-*rac*)-α-tocopherol from renewable furans uses a long chain C₂₂-enyne (Scheme 13),[93] which was constructed from 6,10,14-trimethylpentadecan-2-one and bromotriphenyl(4-(triisopropylsilyl)but-3-yn-1-yl)phosphorane. This C₂₂-enyne was converted with 2,5-DMF to the desired phenol derivative. Oxidation to the quinone, followed by reduction and acid-catalyzed ring closure to the corresponding chromane, resulted in (all-*rac*)-β-tocopherol which can be transformed to (all-*rac*)-α-tocopherol by standard methylation procedures.

<figure><img src="image_1.png" /><figcaption>Scheme 13. (all-*rac*)-β-Tocopherol synthesis from dimethylfuran and C22-enyne.</figcaption></figure>

The authors are thankful to Dr. T. Netscher for recognizing the incorrect content and they apologize for the inconveniences caused.

<footnote>[93] U. Létinois, T. Netscher, WO Patent Appl. No. WO2016096566, **2016**.</footnote>

<footnote>*Correspondence: Dr. M. Marty, E-mail: Maurus.Marty@DSM.com, DSM Nutritional Products</footnote>