# Discussions of Antibiotic Resistance on Social Media Platforms: Text Mining and Mixed Methods Content Analysis Study

Jocelyne Arquembourg, Philippe Glaser, France Roblot, Isabelle Metzler, Mélanie Gallant-Dewavrin, Hugues Feutze Nanguem, Adel Mebarki, Paméla Voillot, Stéphane Schück

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Jocelyne Arquembourg, Philippe Glaser, France Roblot, Isabelle Metzler, Mélanie Gallant-Dewavrin, et al.. Discussions of Antibiotic Resistance on Social Media Platforms: Text Mining and Mixed Methods Content Analysis Study. JMIR Formative Research, 2025, 9, pp.e37160-e37160. 10.2196/37160. pasteur-05453204

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Original Paper

# Discussions of Antibiotic Resistance on Social Media Platforms: Text Mining and Mixed Methods Content Analysis Study

Jocelyne Arquembourg<fnref n="1" />*, PhD; Philippe Glaser<fnref n="2" />*, PhD; France Roblot<fnref n="3" />*, PhD, MD; Isabelle Metzler<fnref n="4" />, MSc; Mélanie Gallant-Dewavrin<fnref n="5" />, MSc; Hugues Feutze Nanguem<fnref n="6" />,<fnref n="7" />, MPA; Adel Mebarki<fnref n="8" />, MBA; Paméla Voillot<fnref n="8" />*, MSc; Stéphane Schück<fnref n="8" />, MD

**Corresponding Author:**

Paméla Voillot,
Kap Code
146 Rue Montmartre
Paris, 75002
France
Phone: 33 625530241
Email: pamela.voillot@kapcode.fr

## Abstract

**Background:** With the increasing popularity of web 2.0 apps, social media has made it possible for individuals to post messages on antibiotic ineffectiveness. In such online conversations, patients discuss their quality of life (QoL). Social media have become key tools for finding and disseminating medical information.

**Objective:** To identify the main themes of discussion, the difficulties encountered by patients with respect to antibiotic ineffectiveness and the impact on their QoL (physical, psychological, social, or financial).

**Methods:** A noninterventional retrospective study was carried out by collecting social media posts in French language written by internet users mentioning their experience with antibiotics, and the impact of their ineffectiveness on their QoL. Messages posted between January 2014 and July 2020 were extracted from French-speaking publicly available online forums.

**Results:** A total of 3773 messages were included in the analysis corpus after extraction and filtering. These messages were posted by 2335 individual web users, most of them being women around 35 years of age. Inefficacy of treatment options and the lack of information regarding the use of antibiotics were among the most discussed topics. QoL was discussed in 63% of the 3773 messages posted. The most common is the physical impact (78%). Patients discussed the persistence of symptoms and adverse effects. The second kind of impact is psychological (65%), characterized by feelings of anxiety or despair about the situation.

**Conclusions:** This social media analysis allowed us to identify a strong impact of the perceived ineffectiveness of antibiotic therapy on patients' daily life particularly in terms of physical and psychological consequences. These results provide health care experts information directly generated by patients regarding their own experiences. Social media studies constitute a complementary source of evidence that could be used to optimize messages to the public about appropriate use of antibiotics.

JMIR Form Res 2025;9:e37160; doi: 10.2196/37160

<footnote n="1">¹Laboratoire 13, Telecom Paris, Telecom Paris, Palaiseau, France</footnote>

<footnote n="2">²Unité EERA Institut Pasteur, CNRS UMR3525, Université de Paris, Paris, France</footnote>

<footnote n="3">³CHRU Poitiers, INSERM U1070, CHRU Poitiers, Poitiers, France</footnote>

<footnote n="4">⁴Association France Spondyloarthrites, Association France Spondyloarthrites, Tulle, France</footnote>

<footnote n="5">⁵Association HTaPFrance, Association HTaPFrance, Meursault, France</footnote>

<footnote n="6">⁶CREDIMI: Center for Research on International Market and Investment Law, University of Burgundy, Dijon, France</footnote>

<footnote n="7">⁷Pfizer, Paris, France</footnote>

<footnote n="8">⁸Kap Code, Paris, France</footnote>

<footnote>*these authors contributed equally</footnote>
**Keywords:** antibiotic ineffectiveness; antibiotic resistance; health-related quality of life; real-world; social media; quality of life; quantitative; qualitative; app; application; online; medical information; French; users; antibiotic; social media use

Introduction

When antibiotics were first introduced in the middle of the
20th century, they were hailed as wonder drugs. Patients and
physicians alike were amazed at the almost miraculous effect
of these drugs on serious bacterial infections. For the past 70
years, physicians have come to expect that antibiotics would
cure almost all their patient's bacterial infections, and patients
expect that the miracle drugs will still work wonders. Despite
an increasing rate of antibiotic resistance globally, they
remain one of the most cost-effective, life-saving medicines
contributing to an extended lifespan [1].

Commonly prescribed antibiotics are becoming less
effective in everyday populations over time as a result of
inappropriate prescriptions, unnecessary use, or their overuse
in both humans and animals. At the same time, research and
development on new antibiotics has slowed down [2]. It is to
note that almost all the new antibiotics that have been brought
to market in recent decades are variations of antibiotic drugs
classes that had been discovered by the 1980s.

The European Surveillance of Antimicrobial Consumption
Network showed that large variations in antibiotic use and
antibiotic resistance rates exist across Europe, with higher use
in Southern Europe including France and lower in Northern
Europe [3].

In general, social media refers to forms of electronic
communication (such as websites for social networking and
microblogging) through which users create online commun-
ities to share information, opinions, personal messages,
photos, videos, and other contents within internet apps [4].
Laudon and Traver [5] describe online social networking as
an online social area for people who share common ties that
can interact with one another. Organizations are able to use
the internet to connect with consumers in the health care
field. Consumers heavily rely on information found online
and use internet to gather health care information and connect
with other patients to garner support and learn about similar
conditions. Individuals will use social media to post reviews
or other comments that support or possibly deter others from
choosing that type of health care in the future. It is essen-
tial for providers to be active on social media and provide
accurate information and connect with readers. Certain groups
use online channels more often depending on the topic they
are searching for. And people responsible for others, such as
parents or caregivers, search health topics even more. Almost

90% of adult users accessed popular social media sites to find
and share health information [6]. People aged 18 to 24 years
are twice as likely to use social media to discuss health issues
than people aged between 45 to 54 years [7].

The digitizing of health care data, as well as advance-
ments in computer processing and data storage, has enabled
the development of advanced algorithms in the form of
artificial intelligence (AI) [8]. AI tools are strongly related
with data mining and AI is nowadays ranked among the
top-10 technology, whichever the application [9]. Despite
their limitations, AI tools and techniques that are still in
their infancy already provide substantial benefits in provid-
ing in-depth knowledge on individuals’ health and predicting
population health risks. Their use for medicine and public
health is expected to increase substantially in the near future
[10].

Health is a multifaceted concept and there is no single
indicator that can adequately assess its impact in relation
to quality of life (QoL). The framework for measuring the
QoL includes, among others, information on the share of the
population with unmet needs for medical and dental care and
a contrasting set of health determinant indicators [11]. In this
study, we collected on the web and sought to analyze the
messages and complaints of patients with antibiotic treatment
failure using innovative tools, without prejudging the cause of
the failure (misuse or antibiotic resistance) in order to identify
the main topics of discussion, and to identify the difficulties
encountered by patients regarding antibiotic ineffectiveness
and the impact on their quality of life (physical, psychologi-
cal, social, or financial).

Methods

Study Design and Population

This was a noninterventional retrospective study using a text
mining approach to retrieve information from social media
posts (data available in the public domain) written by French
speaking internet users between 2014 and 2020 (Figure 1).
The study was conducted in 2 phases, data collection using
the published Detec't webcrawler [12,13] developed by Kap
Code (Paris, France) to collect antibiotic resistance-related
posts and quantitative and qualitative analyses to identify
trends and characterize key topics discussed by French
speaking users.
<figure><img src="image_2.png" /><figcaption>**Figure 1.** Study framework.</figcaption></figure>

## Data Extraction

A web crawler is an engine that browses through hyperlinks and stores them for future download of associated web pages (identified by the visited hyperlinks) [14]. Scraping of messages was performed according to the HTML structure of each forum. All discussions containing at least one of the keywords or one of their synonyms, coupled with the search for a lexical field of inefficiency within the same

message (eg, inefficient or does not work), were automatically retrieved with all the associated metadata and anonymized before being stored in a study-specific database.

Messages associated with antibiotic's supposed inefficiency were retrieved from 46 French sources (such as Doctissimo [Reworld Media], Twitter [rebranded as X], and listed in Table 1) dating from 2014 to 2020.

<table><caption>**Table 1.** Data sources. Messages about lack of efficacy of antibiotics and antibiotic resistance were retrieved from 46 French sources.</caption><thead><tr><td>Forums</td><td>Posts, n</td><td>Users, n</td></tr></thead><tbody><tr><td>Twitter (X)</td><td>888</td><td>475</td></tr><tr><td>Doctissimo</td><td>885</td><td>621</td></tr><tr><td>Atoute</td><td>396</td><td>131</td></tr><tr><td>Futura-Sciences</td><td>260</td><td>135</td></tr><tr><td>Au féminin</td><td>171</td><td>126</td></tr><tr><td>Meamedica</td><td>125</td><td>124</td></tr><tr><td>Les impatientes</td><td>123</td><td>54</td></tr><tr><td>Psychologies</td><td>94</td><td>43</td></tr><tr><td>Onmeda</td><td>94</td><td>85</td></tr><tr><td>Journal des femmes</td><td>79</td><td>62</td></tr><tr><td>Maladies rares</td><td>77</td><td>67</td></tr><tr><td>Thyroide</td><td>72</td><td>46</td></tr><tr><td>YouTube</td><td>71</td><td>68</td></tr><tr><td>Psychoactif</td><td>68</td><td>42</td></tr><tr><td>Lymphome espoiri</td><td>61</td><td>41</td></tr><tr><td>Vinted</td><td>53</td><td>40</td></tr><tr><td>Vulgaris Medical</td><td>49</td><td>38</td></tr><tr><td>Ligue contre le cancer</td><td>47</td><td>43</td></tr><tr><td>Andlil</td><td>39</td><td>18</td></tr><tr><td>Alarm.asso</td><td>38</td><td>15</td></tr><tr><td>Maman pour la vie</td><td>37</td><td>29</td></tr><tr><td>Pedia Blog</td><td>13</td><td>7</td></tr></tbody></table>
<table><thead><tr><td>Forums</td><td>Posts, n</td><td>Users, n</td></tr></thead><tbody><tr><td>Forum HardWare</td><td>10</td><td>7</td></tr><tr><td>Other sites</td><td>23</td><td>18</td></tr><tr><td>Total</td><td>3773</td><td>2335</td></tr></tbody></table>

The analysis corpus (Figure 2) consisted of the corpus filtered after the removal of messages containing predetermined keywords written in a language other than French,

post containing animal-related vocabulary, and messages containing at least 1 of the study-specific exclusion words listed in Multimedia Appendix 1.

<figure><img src="image_3.png" /><figcaption>**Figure 2.** Flowchart presenting the steps for creating the analysis corpus.</figcaption></figure>

# Data Analysis

## Age and Gender

Web users' gender is determined through the identification of regular expressions for each gender. First names and gender-associated suffix and prefix are first searched in the username. Then, content of all available messages is screened for gender-specific lexical fields and gender agreements of adjectives and verbs. Finally, a score is computed for each gender and a prediction for the user is obtained by comparing them.

Web users' ages are identified by a 2-fold method. First, regular expressions of age are identified in the total of the user posts. Then, if no expressions were found, a probabilistic

machine learning model predicts an age based on several features. Among them, the model considers syntactic aspects of posts as well as expressed feeling and the source on which the user expresses himself.

## Topic Model

A topic model was applied to identify the themes addressed in each message. Topic models consist of text mining approach aiming to automatically identify the abstract themes addressed in a collection of documents. Such models are based on the hypothesis that each document in the corpus corresponds to a distribution of several topics. A biterm topic model (BTM) was used to identify the topics without previous knowledge. A topic is defined as a subject of discussion, which amounts to tokens that frequently appear
together in a corpus. The BTM considers the whole corpus as a mixture of topics, where each posts' co-occurring pair of tokens (the biterm) is drawn from a specific topic independently, and modeled topics are probability distributions over the biterms [15].

Topics being probability distributions over tokens of the corpus of study, they can be characterized by the highest per-topic probability tokens. Weighting these probabilities through term-frequency inverse document frequency weighting allows to allocate a higher importance to topic-specific tokens. In this case, the per-topic probability of a token was weighted by the inverse of the probabilities of this token in other topics. For each topic, tokens were ranked from highest to lowest weighted probabilities. The first 15 tokens are designated as the set of characteristic tokens and used to manually name the topic.

## QoL

QoL impacts were identified; thanks to an algorithm previously developed [16] on the basis of 2 standardized questionnaires measuring health-related QoL (EQ5D and SF36). The algorithm is 2-fold. First, it indicates if an impact is expressed and, second, thanks to 5 specific models, it indicates the nature of the impact (physical, psychic, activity-related, relational, or financial). The 6 models (1 for the first step and 5 for the second) are extreme gradient boosting models trained on annotated patients posts related

various pathologies. Features involved in both steps of the algorithm describe expressed feelings, grammar, conjugation, and lexical fields of health-related QoL-related features, integrating semantic fields specific to the social media domain, allowing it to capture the patient experience as closely as possible. This algorithm was used to automatically create groups of posts as per type of impact, which were subsequently manually reviewed.

## Ethical Considerations

This study included data from publicly available sources; private groups and web pages were thus excluded from our data extraction process. We did not seek approval as users automatically grant their consent for the reuse of their data when they post on public platforms. Furthermore, the results of this study do not contain any identifiable information and are presented in aggregate. Information such as the name, username or handle, geographic locations, or any other sensitive data were not included.

## Results

### Description of the Population and Posts

After filtering and formatting, the analysis corpus contained a total of 3773 messages corresponding to 2335 different web users, with a mean of 1.62 posts per user (Figure 3).

<figure><img src="image_4.png" /><figcaption>**Figure 3.** Methodology.</figcaption></figure>

Data showed that there is no specific forum for the sharing of information on activities relating to lack of efficacy of antibiotics and antibiotic resistance and a disparity of sources with a significant proportion of extracted data coming from X and Doctissimo with 888 (23.5%) and 885 (23.5%) posts out of 3773, respectively (Table 1). Furthermore, there was no connection between sources, suggesting a lack of structuring and of visibility of information networks.

We observed fluctuations in the evolution of the volume of messages between January 2014 and July 2020 (Figure 4). We observe a seasonality effect mainly during the “cold” and flu periods, from November to March.
<figure><img src="image_5.png" /><figcaption>**Figure 4.** Fluctuations in the evolution of the volume of messages between January 2014 and July 2020.</figcaption></figure>

Most users were determined as being women (2015/2337, 86.22%), and the average age was estimated of about 35 years (Figure 5). This is consistent with the results of many studies that point out that women express more personal

issues in social networks [17,18]. Furthermore, mothers are more likely to seek advice and help about their infants' health from multiple sources, including social media [19].

<figure><img src="image_6.png" /><figcaption>**Figure 5.** Age distribution.</figcaption></figure>
## Discussion Themes and Topics

As shown in Table 2, the BTM identified 13 main themes of discussion. The largest category of topics was related to the inefficacy of treatment options (“ineffective antibiotics” [597/3770, 15.84%]), especially for ambulatory diseases such as cystitis (356/3770, 9.44%), acne (226/3770, 5.99%),

or dental disorders (109/3770, 2.89%), followed closely by the lack of information regarding their use (“antibiotics and pregnancy,” 402/3770, 10.66%). Furthermore, our findings showed a certain degree of superficiality in the knowledge regarding antibiotics resistance (351/3770, 9.31%) and antibiotics overuse (301/3770, 7.98%).

<table><caption>**Table 2.** Distribution of posts by overall topic category. Application of a biterm topic model that automatically identifies the different topics addressed within the message corpus. Each theme is associated with a set of characteristic words which allows to define them. A message can only be associated with 1 theme.</caption><thead><tr><td>Topics</td><td>n (%)</td></tr></thead><tbody><tr><td>Ineffective antibiotics</td><td>597 (15.84)</td></tr><tr><td>Antibiotics and ear, nose, and throat disorder</td><td>461 (12.23)</td></tr><tr><td>Antibiotics and pregnancy</td><td>402 (10.66)</td></tr><tr><td>Persistent urinary infections</td><td>356 (9.44)</td></tr><tr><td>Mechanisms of resistance</td><td>351 (9.31)</td></tr><tr><td>Antibiotics overuse</td><td>301 (7.98)</td></tr><tr><td>Inappropriate use of antibiotics</td><td>272 (7.21)</td></tr><tr><td>Medical data exchanges</td><td>238 (6.31)</td></tr><tr><td>Antibiotics and acne</td><td>226 (5.99)</td></tr><tr><td>Gastrointestinal impact of antibiotics</td><td>137 (3.63)</td></tr><tr><td>Dental disorders and antibiotics</td><td>109 (2.89)</td></tr><tr><td>Sensitivity analysis antibiogram</td><td>77 (2.04)</td></tr><tr><td>Nosocomial infection</td><td>66 (1.75)</td></tr></tbody></table>

## QoL

QoL is an important criterion for evaluating the effects of a disease and of treatment interventions. In this study, the personal experience of the users in terms of impact on QoL was assessed as physical well-being, social well-being, financial well-being, emotional or psychological well-being, and day-to-day activities. Among the 3773 messages posted, 63% (2384) contained at least 1 impact related to the ineffectiveness of antibiotic treatment on their daily life (Table 3). The most reported impact is physical (1866, 78% of messages), with patients discussing the persistence

of symptoms (pain and fatigue), and adverse effects (diarrhea and joint pain). Psychological impact (1551, 65% of messages) is characterized by feelings of anxiety, fear, or despair, with some messages even mentioning depression. Current activities (745, 31% of messages) were also impacted, with sick leave, professional difficulties, or a decrease in regular physical activities. Social impact (602, 25% of messages) was marked by family or sexual problems and feelings of social isolation. Financial impact was less discussed in only 1% (28) of the messages, with messages essentially related to unnecessary expenses or care coverage.

<table><caption>**Table 3.** Impact of antibiotic treatment ineffectiveness on patients' quality of life.</caption><thead><tr><td>Impact</td><td>n (%)</td></tr></thead><tbody><tr><td>Physical</td><td>1866 (39)</td></tr><tr><td>Psychological</td><td>1551 (32)</td></tr><tr><td>Day-to-day activities</td><td>745 (16)</td></tr><tr><td>Social</td><td>602 (13)</td></tr><tr><td>Financial</td><td>28 (1)</td></tr></tbody></table>

## Discussion

### Principal Findings

Using a web-based tool, we have been able to assess retrospectively how (web user) patients perceive lack of efficacy of antibiotics in France over the last 7 years. Most users were women, and the average age was of about 35 years (Figure 5). Discussions were mainly about therapeutic

wandering, without a strong knowledge about antibiotics mechanism of action and antibiotic resistance. This situation might be due to some lack of knowledge and interest on the subject, highlighting the wandering without addressing the essential points at the origin of the lack of efficacy like prescription of antibiotics in case of viral infection. Furthermore, we showed that there is a strong impact of perceived ineffectiveness of antibiotic therapy on the QoL
of the patients, especially a strong physical and psychological impact for diverse infections and situations.

## Limitations of the Study

This study is to our knowledge the first analysis of messages posted on social media and related to antibiotic resistance in human medicine. It also shows several limitations. First, by focusing only on terms in the French language, we will have underreported the total volume of messages related to antibiotics resistance, and thus, these results are not generalizable at a worldwide scale. Furthermore, using social media to analyze patients' reactions excludes patients who do not have access to the internet or who are not familiar with the use of online discussions.

Extraction bias and a limited amount of data compared with similar studies related to other patient groups (such as breast cancer) were the second limitation. Even if a reasonable sized set of keywords was used, keyword selection in social media studies can induce varying levels of extraction bias, accentuated by a low volume of data.

Another limitation of using social media is the lack of complete information about individual cases. There is also the problem of discovering demographic information—only limited or no information regarding individual user demographics (such as age and origin) may be available.

Despite these limitations, social media represent an ideal place where patients can freely and spontaneously discuss their experiences along with their therapy, thus providing valuable information on their QoL difficult to access by other means. Nevertheless, these observations should be interpreted cautiously, since social media data may include a higher frequency of erroneous information, and patients posting on social media forums may not be representative of the wider patient population.

## Implications and Future Research

Messages published on social networks should be integrated into the assessment of patient's QoL, as they can help to characterise the patient's experience in a more individualized and spontaneous way. Furthermore, it seems important to further explore certain subpopulations (eg, pregnant women, children, or even older adults via their parents or caregivers).

To the extent that the most dominant topics can be interpreted as unmet informational needs, our study highlights

the refinement of practical implications such as the improvement of existing tools, and further reinforcement of the use of available tools (such as antibiotic susceptibility testing or rapid detection tests), and as well as the communication around them.

The ability of internet users to attribute this perceived ineffectiveness to inadequate prescribing or antibiotic resistance is not perceptible in this study and could be the subject of further analysis.

This study suggested to carry out a study segmented by year to examine the evolution of the different subjects (QoL, topics, and treatments) over the years and to observe the global evolutions. Furthermore, similar studies in another country, such as Germany or the United Kingdom, should be planned to compare messages posted between three countries with similar way of life and growth domestic product.

## Conclusion

Given that health information is shared extensively on social networks, such services can potentially be used to gather important real-time health data and may provide a venue to identify potential misuse or misunderstanding of antibiotics, promote positive behavior change, and disseminate valid information related to QoL and to bacterial and nonbacterial infections.

One of the most important challenge for health care professionals is to educate people about antibiotics, their adverse effects, and to encourage them to stop the misuse of such drugs. Our study illustrates the current situation concerning the lack of efficacy of antibiotics and the paucity of valuable information and treatment options for wandering patients. In our case, nothing allows us to affirm that these are therapeutic failures related to antibiotic resistance, inappropriate prescriptions or misuse by patients. However, it can provide health care experts with direct patient input on their experience in real-life conditions. This web analysis made it possible to collect, for the first time, the expression of patients who have failed antibiotic therapy. While the extent of these failures is difficult to demonstrate, these patients' experiences tell us how they feel. This research deserves to be continued to better understand the evolution of this phenomenon.

## Acknowledgments

Medical writing support was provided by Nathalie Baudry of the microenterprise NB-Pharmaconsult. The study was funded by Pfizer SAS.

## Conflicts of Interest

LO has disclosed that he is employee of Pfizer. FNH, PV, and SS have disclosed that they are employees of Kap Code, a CRO, which contracted with Pfizer to carry out this study.
PG, JA, IM, and MG-D have nothing to declare.

## Multimedia Appendix 1

List of exclusion words used to filter the extraction of messages.

[DOCX File (Microsoft Word File), 25 KB-Multimedia Appendix 1]
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## Abbreviations

**AI:** artificial intelligence

**BTM:** biterm topic model

**QoL:** quality of life

Edited by Amaryllis Mavragani; peer-reviewed by Jingheng Cai, Tristan Delory; submitted 24.02.2022; final revised version received 26.09.2022; accepted 27.09.2022; published 25.04.2025

Please cite as:

Arquembourg J, Glaser P, Roblot F, Metzler I, Gallant-Dewavrin M, Nanguem HF, Mebarki A, Voillot P, Schück S

Discussions of Antibiotic Resistance on Social Media Platforms: Text Mining and Mixed Methods Content Analysis Study
JMIR Form Res 2025;9:e37160

URL: https://formative.jmir.org/2025/1/e37160

doi: 10.2196/37160

© Jocelyne Arquembourg, Philippe Glaser, France Roblot, Isabelle Metzler, Mélanie Gallant-Dewavrin, Hugues Feutze Nanguem, Adel Mebarki, Paméla Voillot, Stéphane Schück. Originally published in JMIR Formative Research (https://formative.jmir.org), 25.04.2025. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Formative Research, is properly cited. The complete bibliographic information, a link to the original publication on https://formative.jmir.org, as well as this copyright and license information must be included.