# TCOF1 wt Allele

National Cancer Institute

## Source

National Cancer Institute. TCOF1 wt Allele, NCI Thesaurus. Code C75598.

Human TCOF1 wild-type allele is located within 5q32-q33.1 and is approximately 43 kb in length. This allele, which encodes treacle protein, may play a fundamental role in early embryonic development, particularly in the development of the craniofacial complex.
Mutations in this gene are associated with Treacher Collins syndrome.