# Characterization of the passive mechanics at three different structural levels of the muscle

Philippe Pouletaut, Yoann Tatarenko, M Li, Venus Joumaa, Mashhour

Chakouch, John R. Hawse, Walter Herzog, Simon Chatelin, Sabine

Bensamoun

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Philippe Pouletaut, Yoann Tatarenko, M Li, Venus Joumaa, Mashhour Chakouch, et al.. Characterization of the passive mechanics at three different structural levels of the muscle. Rencontres du GDR MECABIO Santé 2022, Groupe De Recherche (GRD) Mecabio Santé; GDR Réparer l'Humain, Nov 2022, Paris, France. hal-03880223

HAL Id: hal-03880223

https://hal.science/hal-03880223

Submitted on 1 Dec 2022

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Characterization of the passive mechanics at three different structural levels of the
muscle

P. Pouletaut<fnref n="1" />, Y. Tatarenko<fnref n="1" />,<fnref n="4" />, M. Li<fnref n="2" />, V. Joumaa<fnref n="2" />, M. Chakouch<fnref n="1" />, J.R. Hawse<fnref n="3" />, W. Herzog<fnref n="2" />, S. Chatelin<fnref n="4" />, S.F. Bensamoun<fnref n="1" />

Skeletal muscle is a multiscale tissue whose mechanical properties are usually characterized at only one level. The links between the mechanical responses of myofibrils, fibers, fascicles and the entire muscle are poorly understood and largely under-investigated. Thus, the purpose of this study was to experimentally measure the passive properties of muscle at different scales (macroscopic: muscle, microscopic: fiber, submicron: myofibril). Soleus and extensor digitorum longus (EDL) of mice (slow and fast muscles) were extracted and examined at these three scales. Passive mechanical (ramp, relaxation) tests were applied at each scale to compare the passive properties (Young's modulus, static and dynamic stresses) within a given scale and across scales. This study provides a better understanding of the passive mechanical links between various scales, and might help in multi-scale modeling approaches of skeletal muscles.

<footnote n="1">¹Sorbonne University, Université de Technologie de Compiègne, CNRS UMR 7338, Biomechanics and Bioengineering, Compiègne, France</footnote>

<footnote n="2">²University of Calgary, Faculty of Kinesiology, Human Performance Laboratory, Calgary, Alberta, Canada</footnote>

<footnote n="3">³Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, USA</footnote>

<footnote n="4">⁴ICube, CNRS UMR 7357, University of Strasbourg, Strasbourg, France</footnote>