# Development and evaluation of the gender-specific CONSTANCES job exposure matrix for physical risk factors in France

Francesca Wuytack, Bradley Evanoff, Ann Marie Dale, Fabien Gilbert, Marc Fadel, Annette Leclerc, Alexis Descatha

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## To cite this version:

Francesca Wuytack, Bradley Evanoff, Ann Marie Dale, Fabien Gilbert, Marc Fadel, et al.. Development and evaluation of the gender-specific CONSTANCES job exposure matrix for physical risk factors in France. Scandinavian Journal of Work, Environment and Health, 2023, 10.5271/sjweh.4118. hal-04210150

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Scand J Work Environ Health. 2023;49(8):549-557. doi:10.5271/sjweh.4118

# Development and evaluation of the gender-specific CONSTANCES job exposure matrix for physical risk factors in France

by Francesca Wuytack, PhD,<fnref n="1" /> Bradley A Evanoff, MD, MPH,<fnref n="2" /> Ann Marie Dale, PhD,<fnref n="2" /> Fabien Gilbert, MSc,<fnref n="1" />,<fnref n="3" /> Marc Fadel, MD,<fnref n="1" /> Annette Leclerc, PhD,<fnref n="3" /> Alexis Descatha, MD, PhD <fnref n="1" />,<fnref n="4" />

Wuytack F, Evanoff BA, Dale AM, Gilbert F, Fadel M, Leclerc A, Descatha A. Development and evaluation of the gender-specific CONSTANCES job exposure matrix for physical risk factors in France. *Scand J Work Environ Health.* 2023;49(8):549-557.

**Objectives** This study aimed to construct and evaluate a gender-specific job exposure matrix (JEM) for 27 physical work exposures, based on self-report.

**Methods** We constructed a JEM using questionnaire data on current physical exposures from 29 381 male and 35 900 female asymptomatic workers aged 18-69 years in the French CONSTANCES cohort study. We excluded workers with musculoskeletal pain to reduce potential reporting bias. We grouped 27 self-reported physical exposures using the French national job codes and stratified by gender. We compared individual and group-based exposures using the performance indicators Cohen's kappa (κ), sensitivity, specificity, and area under the receiver operating curve (AUC).

**Results** JEM validation showed fair-to-moderate agreement (κ 0.21-0.60) for most physical exposures for both genders except for 'reach behind' (poor), 'bend neck' (poor), 'finger pinch' (poor), 'standing' (good), 'use computer screen' (good), and 'use keyboard or scanner' (good). We found the highest AUC for 'standing' (men 0.85/ women 0.87), 'kneel/squat' (men 0.80/women 0.81), 'use computer screen' (men/women 0.81), and 'use keyboard or scanner' (men 0.82/ women 0.84). The AUC was <0.60 for only three exposures: 'bend neck' (men 0.58/women 0.57), 'finger pinch' (men 0.56/ women 0.55), and 'reach behind' (men 0.54/ women 0.51).

**Conclusion** The constructed JEM validation measures were comparable for men and women for all exposures. Further research will examine the predictive ability of this gender-specific JEM for musculoskeletal disorders and the relevance of gender-stratification in this process, knowing accuracy of each exposure.

**Key terms** exposure measurement; gender; musculoskeletal disorder; physical exposure.

The Global Burden of Disease study reports that musculo-skeletal disorders (MSD) are a leading cause of disability and sick leave worldwide (1), and physical exposures at work are one of the major determinants of MSD (2-4). Job exposure matrices (JEM) have been used to estimate physical work exposures and predict the risk of MSD (5-7). A JEM is a method in occupational health research that allows estimating workers' exposures to occupational risk factors based on job titles or occupational codes rather than individual exposure data. By estimating exposures based on job titles or occupational codes, JEM allow exposure assignment to individuals in large population cohorts where individual exposure assessment would be

infeasible. Using a JEM is less expensive than collecting individual exposure data, and reduces some types of information bias compared to individual self-reported exposures. JEM can also provide exposure data when individual data collection is difficult or impossible (8, 9). While use of JEM can be a valid and efficient method to estimate work exposures in the absence of individual exposure data, they cannot capture exposure variation between workers in the same job, and thus may lead to non-differential classification of exposures, potentially reducing effect sizes compared to the use of individual exposures (6, 10). Despite these limitations, JEM can be useful in a variety of settings, including occupational

Correspondence to: Alexis Descatha, INSERM U1085, ESTER team, Faculté de santé - Département Médecine, 28 rue Roger Amsler, CS 74521, 49045 Angers cedex, France. [E-mail: alexis descatha@inserm.fr]

<footnote n="1">¹ Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, IRSET-ESTER, SFR ICAT, CAPTV CDC, Angers, France.</footnote>

<footnote n="2">² Division of General Medical Sciences, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.</footnote>

<footnote n="3">³ Unité "Cohortes en Population" UMS 011 Inserm/Université de Paris/, Villejuif, France.</footnote>

<footnote n="4">⁴ Department of Occupational Medicine, Epidemiology and Prevention, Donald and Barbara Zucker School of Medicine, Hofstra/Northwell, USA.</footnote>
health research, estimates of exposure at the population
level, and compensation and surveillance efforts (11).

While most existing JEM are gender-neutral, there is
increasing interest in examining differences in exposure
by gender. Gender may influence the effects of occupation
on health through gender differences in the content and
requirements of jobs, different exposures to work factors,
and gender differences in the impact of work exposures.
Gender-specific (stratified by gender) JEM were recently
developed in Norway (6) and Finland (5). Hanvold et al
(6) concluded that gender stratification seemed impor-
tant to increase the accuracy of group-based exposure
estimation, since they found that the variance explained
by the mechanical exposures they examined was higher
among men than women. Solovieva et al (10) found that
men more frequently reported high physical exposures
than women when looking at individual exposure data.
When examining the predictive validity of their gender-
specific JEM for low-back pain, odd ratios decreased
for some exposures when using group-based rather than
individual self-reported exposures, with some differences
seen between men and women (10). Subsequently, strati-
fication by gender has been recommended in occupational
health research (12, 13). Men and women executing the
same job are not always exposed in the same way and, for
some occupational groups, men and women do not report
the same level of physical exposures despite having the
same occupation (14). All of these factors suggest that
gender-specific JEM may provide more accurate exposure
assessment than JEM that do not account for gender.

This study builds on a previous JEM for physical
work exposures developed in France (15). The Cohorte
des consultants des Centres d'examens de santé (CON-
STANCES) cohort study JEM used self-reported expo-
sure data on physical risk factors from a preliminary
sample (35 526 participants) (16). In their conclusion,
the authors recommended that future work on the full
CONSTANCES cohort should consider gender-specific
stratification given the potential influence of gender
on the frequency and magnitude of awkward postures
and physical workload (17). The objective of the cur-
rent study was to construct a gender-specific JEM for
physical work exposures using a larger sample of the
CONSTANCES cohort data and to evaluate its perfor-
mance by comparing group-based exposure estimates
with individual exposure estimates.

Methods

Population

We used data from the CONSTANCES cohort study,
a large population-based study in France. We included

CONSTANCES participants recruited between 2012
and 2019, aged 18–69 years, who had a job that could
be coded based on their questionnaire response (www.
constances.fr) (16). We only included participants who
were currently working. The CONSTANCES study
is restricted to individuals living in one of the CON-
STANCES ‘départements’ and affiliated to the National
Health Insurance Fund, which includes all salaried
workers and their families, whether they are profession-
ally active, unemployed or retired (>85% of the French
population). The study population does not include
agricultural and self-employed workers.

Measures

At inclusion, data were collected using a validated ques-
tionnaire including gender, musculoskeletal pain, and
job title, as well as work exposures (18, 19). Musculo-
skeletal pain was defined as pain in the past seven days
of ≥6/10 intensity in any of the areas indicated (hand/
wrist, neck, shoulder, elbow, low back, knee/leg). Sev-
eral studies have found that people with musculoskeletal
pain may overestimate workplace physical exposures
(20–22), thus we chose to include only asymptomatic
workers in the analysis. Participants with missing data
on musculoskeletal pain were also excluded.

Job titles were assigned a 4-digit French *Profession et Categorie Sociale* (PCS) occupational code (23). This system includes 486 job codes that can be grouped into eight broad job categories based on the first digit of the code (of which six include current workers; the other two categories being retired people and people not currently working). To obtain reliable estimates, PCS jobs with <10 responses were grouped with comparable jobs to create adequately sized ‘occupational groups’ (a minimum of 10 valid responses for each exposure for each job group. Grouping was done independently by two experts, with disagreement resolved by consensus as previously described (15). This merging process was done separately for male and female workers. There were 280 and 352 occupational groups among female and male workers, respectively.

Physical work exposures were obtained for each job
from a standardized self-reported questionnaire including
27 physical work exposures (15). We stratified data by
gender and then compiled the exposures for each occu-
pational group for men and women separately. Exposures
were measured on 4- and 5-point ordinal scales except
for the exposure ‘physical intensity’ which was measured
on a 15-point scale. Individual ordinal exposure esti-
mates were dichotomized using the cut-off point based
on the SALTSA criteria (for evaluating the work-relat-
edness of upper-extremity musculoskeletal disorders),
where applicable (24). For exposures with no relevant
SALTSA criteria, we dichotomized as follows: a score
of 1 (never/nearly never) and 2 [rarely (<2 hours/day)] were considered less exposed, and 3 [often (2–4 hours/day)] and 4 (always or nearly always) were considered exposed. In addition, we created continuous group-based exposures from the original ordinal scale using a method described in the existing gender-neutral CONSTANCES JEM by Evanoff et al (15); we converted the ordinal exposure measures to a continuous scale (time exposed in minutes): 5 minutes (rating of 1=never or nearly never), 60 minutes [rating of 2=rarely (<2 hours per day)], 180 minutes [rating of 3=often (2–4 hours per day)] and 360 minutes (rating of 4=always or nearly always).

## Analyses

To construct the gender-specific JEM, we stratified the data by gender and created the exposure estimates by occupational groups for males and females. Then we calculated individual and group-based (JEM) exposure estimates. For the individual exposures, we used the dichotomized exposure variables as described above to categorize workers as exposed or not exposed. We constructed and evaluated the gender-specific JEM using methods comparable to JEM previously developed in Norway (6) and Finland (5). To calculate the occupational group-based estimates, we stratified the data by gender, and calculated group-based exposure estimates separately for men and women for each exposure within each occupational group. To define exposed and not exposed workers (ie, the JEM proportion of workers exposed) for each occupational group, we dichotomized group-based exposures as follows: if a pre-specified proportion of workers in an occupational group were exposed (based on thresholds for work-related exposure level of the individual self-report data), then the occupational group was considered exposed (score of 1), otherwise, the group was classified as non-exposed (score of 0) for that physical exposure. We computed results using four pre-specified cut off levels (20%, 30%, 40%, or 50%) and then chose the optimal cut-off level for each of the 27 exposures based on the performance indicators (sensitivity, specificity, AUC, κ). We considered all four performance indicators in deciding the optimal cut-off, but gave priority to the highest area under the receiver operating characteristics curve (AUC) and to specificity (see supplementary material, www.sjweh.fi/article/4118, appendix 1). In addition, we calculated the following measures for the group-based estimates (15): mean [standard deviation (SD)], continuous mean (SD), median (and 25th and 75th quartiles), bias-corrected mean, and bias-corrected continuous mean. We obtained the bias-corrected mean and bias-corrected continuous mean using empirical quantile mapping whereby mean values that were within every 1% quantile range were adjusted to reflect the respective 1% quantiles of the individual-level reported values (15, 25).

To evaluate the performance of the gender-specific JEM, we computed performance indicators separately for the male and female JEM and compared results. We used four performance indicators to compare the group-based exposure estimates with the individual exposure measures (proportion of workers exposed based on individual self-reported data) (i): Cohen's κ coefficient to measure agreement (ii), sensitivity (proportion of exposed individuals in the individual-based estimates that are identified as exposed in the group-based estimates) (iii), specificity (proportion of less exposed individuals in the individual-based estimates that are identified as less exposed in the group-based estimates), and (iv) AUC to measure the ability of the JEM to classify exposed and non-exposed individuals. We applied the following classification for Cohen's kappa coefficient: poor (<0.21), fair (0.21–0.40), moderate (0.41–0.60), good (0.61–0.80) and excellent (0.81–1) agreement (26). We also estimated the variance (R²) in individual exposure estimates that was explained by the occupational groups using analysis of variance (ANOVA). For this ANOVA, the continuous exposure measures were used as dependent variable. Statistical analyses were conducted in Stata 17 (27) and R V4.3.0 software (28) with Qmap and Haven packages.

## Results

### Description of sample

The CONSTANCES data set included a total of 205 203 participants. We excluded non-working participants and participants with incomplete or missing PCS codes (figure 1). Subsequently, 112 062 workers were included in the data set for analysis. After excluding workers with musculoskeletal pain, as defined above, we included 29 381 male and 35 900 female asymptomatic workers.

The mean age for men was 43.5 years (SD 10.4) and 43.2 years (SD 10.4) for women, and the mean body mass index (BMI) was 25.3 kg/m² (SD 3.9) and 24.1 kg/m² (SD 4.7) for men and women respectively. The most common of the six occupational categories (based on the first digit of the PCS code) for men was “executives and higher intellectual entrepreneurs” (including jobs such as doctors, engineers etc). The most common category for women was “intermediate profession” (including jobs such as schoolteachers, nurses etc) (table 1).

### Evaluation of the gender-specific JEM

The JEM are accessible in the supplementary material. Distribution of JEM is presented in table 2. The JEM performance measures (κ, sensitivity, specificity, AUC)
<figure><img src="image_3.png" /><figcaption>**Figure 1.** Flowchart of participants of the French CONSTANCES cohort included in the study</figcaption></figure>

using the different cut-offs (20%, 30%, 40%, 50%) to estimate the group-based exposure estimates, stratified by gender, are outlined in full in supplementary appendix 1. For most exposures the optimal cut-off was 20% or 30% (table 3). The exceptions were exposures that are common in many jobs (standing, change tasks, rest eyes, use computer screen, use keyboard or scanner), for which the optimal cut-off was 50%. The optimal cut-offs were the same for both genders.

The performance measures of the constructed gender-specific JEM were comparable for both genders across most exposures (table 3). Agreement (κ) was fair-to-moderate for most physical exposures for both genders except for the exposures of ‘reach behind’ (poor), ‘bend neck’ (poor), ‘standing’ (good), ‘use computer screen’ (good), and ‘use keyboard or scanner’ (good). We found the highest AUC for ‘standing’ (men 0.85/women 0.87), ‘kneel/squat’ (men 0.80/women 0.81), ‘use computer screen’ (men/women 0.81), and ‘use keyboard or scanner’ (men 0.82/women 0.84). The AUC was <0.60 for only three exposures: ‘bend neck’ (men 0.58/women 0.57), ‘finger pinch’ (men 0.56/women 0.55), and ‘reach behind’ (men 0.54/women 0.51).

Examining the performance of the JEM by looking at the explained variance (R²) is shown in table 3. The

<table><caption>**Table 1.** Characteristics of working participants of the French CONSTANCES cohort with complete profession and social category codes.</caption><thead><tr><th rowspan="2">Occupational category</th><th>Male</th><th>Female</th></tr><tr><th>(N=29 381)</th><th>(N=35 900)</th></tr><tr><th></th><th>N (%)</th><th>N (%)</th></tr></thead><tbody><tr><td>Farmers</td><td>14 (0.05)</td><td>8 (0.02)</td></tr><tr><td>Craftsmen, traders and entrepreneurs</td><td>598 (2.0)</td><td>225 (0.6)</td></tr><tr><td>Executives and higher intellectual professions</td><td>12 120 (42.3)</td><td>10 037 (28.0)</td></tr><tr><td>Intermediate professions</td><td>9011 (30.7)</td><td>15 894 (44.3)</td></tr><tr><td>Salaried employees</td><td>2776 (9.4)</td><td>8802 (24.5)</td></tr></tbody></table>

amount of variance in individual exposures explained by the occupational groups ranged from 9% (bend neck, reach behind) to 51% (standing) in men, and 3% (reach behind) to 61% (standing) in women. The largest differences in the performance measures between genders were: ‘drive machinery’ (R²: male 0.30; female 0.09); ‘use vibrating tools’ (R²: male 0.38; female 0.17); ‘rotate forearm’ (R²: male 0.34; female 0.11); ‘press base of hand’ (R²: male 0.32; female 0.07) and ‘work outdoors’ (R²: male 0.34, female 0.19).

## Discussion

We constructed and evaluated a gender-specific JEM for 27 physical work exposures based on self-reported data from a large national French cohort study. The gender-specific JEM showed fair-to-moderate agreement with individual self-reported physical exposure measures at work. These findings are comparable to other existing gender-specific physical exposures JEM in Finland (5) and Norway (6). JEM provide crude estimates of exposures, and it is to be expected that the accuracy of estimation varies across factors. Our JEM performed less well for the exposures reaching behind, bending neck and pinching finger. In these groups, occupational group explained little of the variation in individual exposures. For neck flexion, Hanvold et al (6) also found a lower JEM performance (AUC male 0.61; AUC female 0.62) but they did not examine reaching behind and finger pinching. Solovieva et al (5) did not examine these three exposures. We found that lower cut-offs (20%-30%) performed better for less prevalent exposures when assessing κ, sensitivity, specificity, and AUC, while a higher cut-off (50%) performed better for more prevalent exposures. This emphasizes the importance of careful selection of cut-off levels in constructing group-based exposure measures (6). To develop the JEM, we included only asymptomatic workers since symptomatic workers have been found to report higher physical exposures than asymptomatic workers in the same jobs (15, 20, 21). Also, past analyses of a JEM created from the CONSTANCES cohort showed that excluding workers with
<table><caption>**Table 2.** Distribution of the job exposure matrix. [SD=standard deviation, P=percentile].</caption><thead><tr><th></th><th>N</th><th>Mean</th><th>SD</th><th>Minimum</th><th>5<sup>th</sup> P</th><th>25<sup>th</sup> P</th><th>Median</th><th>75<sup>th</sup> P</th><th>95<sup>th</sup> P</th><th>Maximum</th></tr></thead><tbody><tr><td><strong>Men</strong></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Physical intensity</td><td>28 883</td><td>9.90</td><td>3.22</td><td>6</td><td>6</td><td>7</td><td>9</td><td>13</td><td>15</td><td>20</td></tr><tr><td>Standing</td><td>29 012</td><td>2.58</td><td>1.06</td><td>1</td><td>1</td><td>2</td><td>2</td><td>4</td><td>4</td><td>4</td></tr><tr><td>Repetition</td><td>28 585</td><td>1.65</td><td>1.02</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td><td>4</td></tr><tr><td>Change tasks</td><td>28 685</td><td>3.01</td><td>1.06</td><td>1</td><td>1</td><td>2</td><td>3</td><td>4</td><td>4</td><td>4</td></tr><tr><td>Rest eyes</td><td>28 717</td><td>3.24</td><td>1.05</td><td>1</td><td>1</td><td>3</td><td>4</td><td>4</td><td>4</td><td>4</td></tr><tr><td>Knee or squat</td><td>29 011</td><td>1.49</td><td>0.84</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>3</td><td>4</td></tr><tr><td>Bend trunk</td><td>28 962</td><td>1.54</td><td>0.88</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td><td>4</td></tr><tr><td>Drive machinery</td><td>29 005</td><td>1.18</td><td>0.59</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td></tr><tr><td>Drive car or truck</td><td>29 008</td><td>1.56</td><td>0.99</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td><td>4</td></tr><tr><td>Handle objects 1–4 kg</td><td>28 728</td><td>1.24</td><td>1.40</td><td>0</td><td>0</td><td>0</td><td>1</td><td>2</td><td>4</td><td>4</td></tr><tr><td>Handle objects >4 kg</td><td>28 653</td><td>0.90</td><td>1.28</td><td>0</td><td>0</td><td>0</td><td>0</td><td>2</td><td>4</td><td>4</td></tr><tr><td>Carry loads <10 kg</td><td>28 612</td><td>0.96</td><td>1.14</td><td>0</td><td>0</td><td>0</td><td>1</td><td>2</td><td>3</td><td>4</td></tr><tr><td>Carry loads 10–25 kg</td><td>28 702</td><td>0.82</td><td>0.97</td><td>0</td><td>0</td><td>0</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Carry loads >25 kg</td><td>28 678</td><td>0.71</td><td>0.82</td><td>0</td><td>0</td><td>0</td><td>1</td><td>1</td><td>2</td><td>4</td></tr><tr><td>Use vibrating tools</td><td>28 820</td><td>1.18</td><td>0.58</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Use computer screen</td><td>28 903</td><td>3.23</td><td>1.07</td><td>1</td><td>1</td><td>3</td><td>4</td><td>4</td><td>4</td><td>4</td></tr><tr><td>Use keyboard or scanner</td><td>28 866</td><td>3.14</td><td>1.13</td><td>1</td><td>1</td><td>2</td><td>4</td><td>4</td><td>4</td><td>4</td></tr><tr><td>Bend neck</td><td>28 815</td><td>2.19</td><td>1.06</td><td>1</td><td>1</td><td>1</td><td>2</td><td>3</td><td>4</td><td>4</td></tr><tr><td>Arms above shoulder</td><td>28 891</td><td>1.33</td><td>0.67</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Reach behind</td><td>28 893</td><td>1.23</td><td>0.52</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td></tr><tr><td>Arms abducted</td><td>28 831</td><td>1.35</td><td>0.74</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Bend elbow</td><td>28 786</td><td>1.37</td><td>0.78</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Rotate forearm</td><td>28 845</td><td>1.29</td><td>0.69</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Bend wrist</td><td>28 817</td><td>1.36</td><td>0.77</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Press base of hand</td><td>28 837</td><td>1.17</td><td>0.53</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td></tr><tr><td>Finger pinch</td><td>28 833</td><td>1.38</td><td>0.79</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Work outdoors</td><td>29 176</td><td>1.51</td><td>0.90</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td><td>4</td></tr><tr><td><strong>Women</strong></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Physical intensity</td><td>35 131</td><td>9.69</td><td>3.19</td><td>6</td><td>6</td><td>7</td><td>9</td><td>12</td><td>15</td><td>20</td></tr><tr><td>Standing</td><td>35 420</td><td>2.59</td><td>1.15</td><td>1</td><td>1</td><td>2</td><td>2</td><td>4</td><td>4</td><td>4</td></tr><tr><td>Repetition</td><td>34 545</td><td>1.74</td><td>1.08</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td><td>4</td></tr><tr><td>Change tasks</td><td>34 625</td><td>2.86</td><td>1.13</td><td>1</td><td>1</td><td>2</td><td>3</td><td>4</td><td>4</td><td>4</td></tr><tr><td>Rest eyes</td><td>34 592</td><td>2.98</td><td>1.17</td><td>1</td><td>1</td><td>2</td><td>3</td><td>4</td><td>4</td><td>4</td></tr><tr><td>Knee or squat</td><td>35 400</td><td>1.62</td><td>0.93</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td><td>4</td></tr><tr><td>Bend trunk</td><td>35 282</td><td>1.69</td><td>0.98</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td><td>4</td></tr><tr><td>Drive machinery</td><td>35 409</td><td>1.03</td><td>0.24</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>4</td></tr><tr><td>Drive car or truck</td><td>35 404</td><td>1.23</td><td>0.65</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Handle objects 1–4 kg</td><td>34 852</td><td>1.05</td><td>1.27</td><td>0</td><td>0</td><td>0</td><td>1</td><td>2</td><td>4</td><td>4</td></tr><tr><td>Handle objects >4 kg</td><td>34 751</td><td>0.70</td><td>1.13</td><td>0</td><td>0</td><td>0</td><td>0</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Carry loads <10 kg</td><td>34 651</td><td>0.78</td><td>1.00</td><td>0</td><td>0</td><td>0</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Carry loads 10–25 kg</td><td>34 674</td><td>0.66</td><td>0.81</td><td>0</td><td>0</td><td>0</td><td>1</td><td>1</td><td>2</td><td>4</td></tr><tr><td>Carry loads >25 kg</td><td>34 705</td><td>0.61</td><td>0.74</td><td>0</td><td>0</td><td>0</td><td>1</td><td>1</td><td>2</td><td>4</td></tr><tr><td>Use vibrating tools</td><td>35 015</td><td>1.04</td><td>0.29</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>4</td></tr><tr><td>Use computer screen</td><td>35 131</td><td>3.24</td><td>1.04</td><td>1</td><td>1</td><td>3</td><td>4</td><td>4</td><td>4</td><td>4</td></tr><tr><td>Use keyboard or scanner</td><td>35 073</td><td>3.15</td><td>1.11</td><td>1</td><td>1</td><td>2</td><td>4</td><td>4</td><td>4</td><td>4</td></tr><tr><td>Bend neck</td><td>34 949</td><td>2.50</td><td>1.10</td><td>1</td><td>1</td><td>1</td><td>3</td><td>3</td><td>4</td><td>4</td></tr><tr><td>Arms above shoulder</td><td>35 087</td><td>1.35</td><td>0.68</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Reach behind</td><td>35 078</td><td>1.24</td><td>0.53</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td></tr><tr><td>Arms abducted</td><td>34 992</td><td>1.30</td><td>0.70</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Bend elbow</td><td>34 919</td><td>1.30</td><td>0.73</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Rotate forearm</td><td>35 063</td><td>1.10</td><td>0.41</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td></tr><tr><td>Bend wrist</td><td>34 983</td><td>1.26</td><td>0.69</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Press base of hand</td><td>35 017</td><td>1.05</td><td>0.29</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>4</td></tr><tr><td>Finger pinch</td><td>34 995</td><td>1.37</td><td>0.82</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>3</td><td>4</td></tr><tr><td>Work outdoors</td><td>35 570</td><td>1.21</td><td>0.53</td><td>1</td><td>1</td><td>1</td><td>1</td><td>1</td><td>2</td><td>4</td></tr></tbody></table>

musculoskeletal symptoms created more homogenous exposure groups (16). The physical exposures in our JEM explained 4–64% of the variance in individually reported exposures. This is comparable to the Norwegian gender-specific JEM where the explained variance ranged from 7–41% (6). The wider range of explained variance in our study could be due to the larger number of physical exposures examined. Hanvold et al (6) concluded that gender-specific group-based exposure levels could be important to improve the accuracy of exposure estimates because

the explained variance estimates (for the eight exposures examined) were somewhat higher among men. We found that the variance in individual exposure explained by occupational group was not always higher among men across the 27 exposures we examined, and the differences were often small. The Finnish gender-specific JEM did not examine the explained variance measure (7). These data on individual variance and group level data will also be useful in choosing exposure measures for studies of association between work exposures and MSDs.
<table><caption>**Table 3.** Agreement measures between individual- and group-based work exposures using the optimal cut-off level by gender. [κ=kappa; AUC=area receiver operating characteristics under the curve; SENS=sensitivity; SPEC=specificity; EG=exposed group; EI=exposed individual.]</caption><thead><tr><th rowspan="2">Physical exposure</th><th rowspan="2">Cut-off</th><th colspan="6">Male asymptomatic workers</th><th colspan="6">Female asymptomatic workers</th></tr><tr><th>κ</th><th>SENS (%)</th><th>SPEC (%)</th><th>AUC</th><th>EG<sup>a</sup> (%)</th><th>EI (%)</th><th>R<sup>2 b</sup></th><th>R<sup>2 c</sup></th><th>κ</th><th>SENS (%)</th><th>SPEC (%)</th><th>AUC</th><th>EG (%)</th><th>EI (%)</th><th>R<sup>2 b</sup></th><th>R<sup>2 c</sup></th></tr></thead><tbody><tr><td>Physical intensity</td><td>20</td><td>0.35</td><td>72.44</td><td>82.71</td><td>0.76</td><td>22.97</td><td>10.30</td><td>0.21</td><td>0.37</td><td>0.33</td><td>64.37</td><td>85.93</td><td>0.75</td><td>18.46</td><td>8.72</td><td>0.19</td><td>0.34</td></tr><tr><td>Standing</td><td>50</td><td>0.70</td><td>78.43</td><td>86.27</td><td>0.85</td><td>45.25</td><td>48.71</td><td>0.51</td><td>0.58</td><td>0.74</td><td>88.50</td><td>85.16</td><td>0.87</td><td>51.13</td><td>49.27</td><td>0.61</td><td>0.64</td></tr><tr><td>Repetition</td><td>20</td><td>0.26</td><td>54.39</td><td>84.44</td><td>0.68</td><td>19.44</td><td>9.99</td><td>0.14</td><td>0.20</td><td>0.26</td><td>51.00</td><td>82.83</td><td>0.67</td><td>21.32</td><td>12.25</td><td>0.14</td><td>0.18</td></tr><tr><td>Change tasks</td><td>50</td><td>0.23</td><td>90.16</td><td>31.51</td><td>0.60</td><td>84.10</td><td>72.06</td><td>0.12</td><td>0.11</td><td>0.20</td><td>86.25</td><td>32.10</td><td>0.59</td><td>80.02</td><td>66.08</td><td>0.08</td><td>0.08</td></tr><tr><td>Rest eyes</td><td>50</td><td>0.36</td><td>93.07</td><td>36.28</td><td>0.66</td><td>86.44</td><td>77.43</td><td>0.19</td><td>0.20</td><td>0.35</td><td>89.25</td><td>42.91</td><td>0.66</td><td>78.96</td><td>68.00</td><td>0.20</td><td>0.21</td></tr><tr><td>Knee or squat</td><td>30</td><td>0.46</td><td>71.02</td><td>84.00</td><td>0.80</td><td>23.70</td><td>14.00</td><td>0.29</td><td>0.33</td><td>0.48</td><td>81.90</td><td>79.72</td><td>0.81</td><td>31.61</td><td>18.39</td><td>0.33</td><td>0.38</td></tr><tr><td>Bend trunk</td><td>30</td><td>0.46</td><td>68.99</td><td>83.16</td><td>0.78</td><td>25.22</td><td>16.08</td><td>0.25</td><td>0.30</td><td>0.48</td><td>77.65</td><td>79.01</td><td>0.78</td><td>33.92</td><td>22.81</td><td>0.30</td><td>0.33</td></tr><tr><td>Drive machinery</td><td>20</td><td>0.41</td><td>51.12</td><td>96.21</td><td>0.72</td><td>6.12</td><td>4.94</td><td>0.30</td><td>0.35</td><td>0.20</td><td>19.03</td><td>99.52</td><td>0.59</td><td>0.62</td><td>0.76</td><td>0.09</td><td>0.10</td></tr><tr><td>Drive car or truck</td><td>20</td><td>0.46</td><td>68.06</td><td>86.08</td><td>0.77</td><td>22.90</td><td>16.59</td><td>0.33</td><td>0.39</td><td>0.37</td><td>49.90</td><td>94.49</td><td>0.72</td><td>8.09</td><td>5.81</td><td>0.28</td><td>0.35</td></tr><tr><td>Handle objects 1-4 kg</td><td>30</td><td>0.41</td><td>54.19</td><td>91.23</td><td>0.73</td><td>13.73</td><td>10.92</td><td>0.24</td><td>0.39</td><td>0.30</td><td>36.14</td><td>95.68</td><td>0.64</td><td>6.30</td><td>6.85</td><td>0.17</td><td>0.31</td></tr><tr><td>Handle objects >4 kg</td><td>20</td><td>0.33</td><td>65.64</td><td>88.40</td><td>0.77</td><td>15.04</td><td>6.37</td><td>0.20</td><td>0.39</td><td>0.31</td><td>49.71</td><td>94.14</td><td>0.72</td><td>7.62</td><td>4.02</td><td>0.16</td><td>0.33</td></tr><tr><td>Carry loads <10 kg</td><td>20</td><td>0.30</td><td>43.71</td><td>94.52</td><td>0.69</td><td>7.23</td><td>4.58</td><td>0.15</td><td>0.33</td><td>0.25</td><td>37.95</td><td>95.91</td><td>0.67</td><td>5.07</td><td>2.90</td><td>0.10</td><td>0.24</td></tr><tr><td>Carry loads 10-25 kg</td><td>20</td><td>0.27</td><td>36.39</td><td>97.14</td><td>0.67</td><td>3.68</td><td>2.43</td><td>0.12</td><td>0.30</td><td>0.19</td><td>28.02</td><td>97.98</td><td>0.63</td><td>2.37</td><td>1.34</td><td>0.09</td><td>0.23</td></tr><tr><td>Carry loads >25 kg</td><td>20</td><td>0.23</td><td>25.25</td><td>98.83</td><td>0.62</td><td>1.51</td><td>1.41</td><td>0.10</td><td>0.24</td><td>0.29</td><td>47.04</td><td>98.27</td><td>0.73</td><td>2.20</td><td>1.02</td><td>0.12</td><td>0.28</td></tr><tr><td>Use vibrating tools</td><td>20</td><td>0.47</td><td>71.40</td><td>90.56</td><td>0.78</td><td>16.19</td><td>10.91</td><td>0.38</td><td>0.30</td><td>0.27</td><td>32.52</td><td>97.47</td><td>0.65</td><td>3.37</td><td>2.81</td><td>0.17</td><td>0.17</td></tr><tr><td>Use a computer screen</td><td>50</td><td>0.60</td><td>91.52</td><td>69.17</td><td>0.80</td><td>77.14</td><td>76.30</td><td>0.47</td><td>0.47</td><td>0.62</td><td>90.47</td><td>71.79</td><td>0.81</td><td>75.29</td><td>75.61</td><td>0.47</td><td>0.46</td></tr><tr><td>Use keyboard or scanner</td><td>50</td><td>0.64</td><td>85.24</td><td>74.01</td><td>0.82</td><td>59.26</td><td>56.16</td><td>0.44</td><td>0.52</td><td>0.68</td><td>84.01</td><td>83.99</td><td>0.84</td><td>54.44</td><td>56.51</td><td>0.53</td><td>0.57</td></tr><tr><td>Bend neck</td><td>30</td><td>0.17</td><td>25.53</td><td>91.15</td><td>0.58</td><td>11.13</td><td>13.66</td><td>0.07</td><td>0.09</td><td>0.16</td><td>30.49</td><td>84.44</td><td>0.57</td><td>18.83</td><td>21.87</td><td>0.06</td><td>0.06</td></tr><tr><td>Arms above shoulder</td><td>20</td><td>0.28</td><td>66.47</td><td>84.79</td><td>0.71</td><td>19.17</td><td>7.72</td><td>0.19</td><td>0.26</td><td>0.26</td><td>46.11</td><td>88.80</td><td>0.67</td><td>14.03</td><td>8.10</td><td>0.13</td><td>0.18</td></tr><tr><td>Reach behind</td><td>20</td><td>0.11</td><td>15.17</td><td>98.56</td><td>0.54</td><td>1.90</td><td>3.40</td><td>0.07</td><td>0.09</td><td>0.05</td><td>2.72</td><td>99.83</td><td>0.51</td><td>0.27</td><td>3.67</td><td>0.03</td><td>0.04</td></tr><tr><td>Arms abducted</td><td>20</td><td>0.32</td><td>65.28</td><td>83.98</td><td>0.73</td><td>20.78</td><td>9.67</td><td>0.17</td><td>0.21</td><td>0.31</td><td>53.59</td><td>88.48</td><td>0.71</td><td>14.99</td><td>8.24</td><td>0.15</td><td>0.18</td></tr><tr><td>Bend elbow</td><td>20</td><td>0.33</td><td>66.68</td><td>83.04</td><td>0.72</td><td>22.37</td><td>10.86</td><td>0.19</td><td>0.23</td><td>0.31</td><td>47.87</td><td>89.72</td><td>0.69</td><td>13.77</td><td>9.30</td><td>0.14</td><td>0.17</td></tr><tr><td>Rotate forearm</td><td>20</td><td>0.45</td><td>66.84</td><td>92.97</td><td>0.75</td><td>11.74</td><td>7.87</td><td>0.34</td><td>0.38</td><td>0.22</td><td>20.27</td><td>98.81</td><td>0.60</td><td>1.63</td><td>2.31</td><td>0.11</td><td>0.14</td></tr><tr><td>Bend wrist</td><td>20</td><td>0.32</td><td>61.25</td><td>85.47</td><td>0.71</td><td>19.42</td><td>10.48</td><td>0.19</td><td>0.21</td><td>0.28</td><td>41.54</td><td>91.88</td><td>0.67</td><td>10.66</td><td>7.59</td><td>0.12</td><td>0.14</td></tr><tr><td>Press base of hand</td><td>20</td><td>0.44</td><td>64.58</td><td>90.92</td><td>0.74</td><td>15.51</td><td>11.59</td><td>0.32</td><td>0.25</td><td>0.16</td><td>14.87</td><td>98.33</td><td>0.57</td><td>2.08</td><td>3.13</td><td>0.07</td><td>0.04</td></tr><tr><td>Finger pinch</td><td>20</td><td>0.17</td><td>18.00</td><td>97.67</td><td>0.56</td><td>3.00</td><td>4.26</td><td>0.09</td><td>0.15</td><td>0.15</td><td>11.89</td><td>98.70</td><td>0.55</td><td>1.83</td><td>5.00</td><td>0.06</td><td>0.10</td></tr><tr><td>Work outdoors</td><td>20</td><td>0.46</td><td>68.89</td><td>87.37</td><td>0.77</td><td>20.94</td><td>14.77</td><td>0.34</td><td>0.42</td><td>0.31</td><td>43.49</td><td>95.52</td><td>0.70</td><td>5.97</td><td>3.82</td><td>0.19</td><td>0.27</td></tr></tbody></table>

In subsequent research, we will assess the predictive ability of this gender-specific CONSTANCES JEM for several MSD. While the agreement measures of this JEM are generally comparable for men and women, previous research has highlighted that differences can exist in physical self-reported exposures between men and women in the same occupational group (14). We will examine the impact of gender stratification when testing the predictive ability of the JEM for several MSDs. This is particularly important since women have higher years lost due to disability due to MSD than men (1). However, further steps are necessary to study the potential gain of gender stratification in terms of the predictive ability of JEM.

## Strengths and limitations

To our knowledge, this is the first gender-specific JEM of physical exposures using a large cohort (CONSTANCES) that included such a large range of physical exposures in the JEM. The 27 exposures that we measured provide a comprehensive list of physical characteristics of occupational groups. This will allow for a detailed examination of physical exposures in relation to various MSD in future studies.

Some limitations should be considered. We included

a large and nationally representative study population, although the CONSTANCES sample under-represents agricultural and self-employed workers (16). We used self-reported data on physical exposures to construct the JEM, and workers might over- or underestimate exposures, leading to exposure misclassification. However, self-reported data have been shown to be useful in examining associations with MSD (29), and direct measurement is expensive and difficult to apply to large cohorts (30). We excluded workers who reported significant pain at the time of the questionnaire to reduce the potential for biased reporting of exposures due to symptoms, and because estimates based on asymptomatic workers resulted in lower within-group variance of reported exposures and created more homogeneous exposure groups in a previous JEM created using CONSTANCES data (16). Use of asymptomatic workers also reduced the mean exposures of the occupational groups, and may have reduced the representativeness of the cohort, especially with a substantial proportion as expected in such population (31, 32). However, the accuracy and reliability of the JEM's application should be analyzed in future studies. For ease of comparison across multiple jobs and exposures, we dichotomized jobs as "exposed" or "less exposed," as has been done in some other JEM studies. This dichotomization may have led to loss of

<footnote>a Exposed group refers to the percentage of exposed individuals for each exposure using the group-exposure (JEM) measure estimates.</footnote>

<footnote>b Variance in individual exposures explained by occupational group using ordinal exposure data as dependent variable.</footnote>

<footnote>c Variance in individual exposures explained by occupational group using continuous exposure data as dependent variable.</footnote>
information and could have reduced our ability to detect
gender-related differences in work exposures. Finally,
JEM capture an overall estimation of exposures at the
time the exposure data were collected, and physical
exposures in some jobs may change over time.

Concluding remarks

We developed a gender-specific JEM for 27 physical exposures based on a large French cohort. In both genders, the JEM showed fair-to-moderate agreement with individual exposure measures. While taking into account its limitations, the JEM can provide a useful tool for exposure estimation when data on individual exposures are lacking (11, 33), and might be applied for most each exposure knowing their accuracy. The findings of the JEM validation measures were comparable for men and women for all exposures. The JEM performed less well for three exposures: reaching behind, finger pinch-ing, and bending the neck. This suggests using caution when applying the JEM for these exposures, and the need for evaluating this ability of these JEM exposures at predicting MSD risk. JEM provide a useful tool for researchers to estimate occupational exposures among men and women in large scale epidemiological studies, especially when exposure assessment is not available. Beyond MSD outcomes, assessing biomechanical expo-sure on a large epidemiological scale could be useful for other research domains, including but not restricted to mental health, burden related to work in an occupational exposome approach or even work trajectories (34). Future research will examine the predictive ability of this gender-specific JEM for MSD and the relevance of gender-stratification in this process by comparing find-ings to a gender-neutral JEM.

Acknowledgments

We would like to thank Sabrina Pitet for her help in
merging PCS groups.

Funding

This project was part of the “TEC-TOP project” which
was funded by a regional public fund of the Pays-de-la-
Loire Region, Angers Loire Metropole, University of
Angers and CHU Angers. The funder had no role in the
study design, the collection, analysis and interpretation
of the data, the writing of the report, and the decision to
submit the paper for publication.

The CONSTANCES cohort study is an “Infrastruc-
ture nationale en Biologie et Santé” and benefits from
a grant from the French National Agency for Research

(ANR-11-INBS-0002). CONSTANCES is also partly
funded by Merck Sharp & Dohme (MSD), AstraZeneca,
Lundbeck and L'Oréal through Inserm-Transfert. None
of these funding sources had any role in the design of
the study, collection and analysis of data or decision to
publish.

Conflicts of interests

The authors declare no conflicts of interest. The authors
are paid by their institution. AD is also paid as editor
of the Archives des Maladies professionnelles et de
l'Environnement (Elsevier).

Ethical approval

The procedures followed were in accordance with
the Helsinki Declaration as revised in 2008. Ethi-
cal approval was granted for CONSTANCES by the
Comité d’Evaluation Ethique de l’Inserm (IRB0000388,
FWA00005831), and by the CCTIRS and CNIL (15-636
and 2017-172 respectively) as part of the overarching
Comett – Musculoskeletal Observatory Cohort study.

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Received for publication: 21 February 2023