# Beneficial role of physical activity in counteracting musculoskeletal disorders induced by early movement restriction

Julien Girardie, Mélanie Van Gaever, Orlane Dupuis, Erwan Dupont,
Marie-Hélène Canu

► To cite this version:

Julien Girardie, Mélanie Van Gaever, Orlane Dupuis, Erwan Dupont, Marie-Hélène Canu. Beneficial role of physical activity in counteracting musculoskeletal disorders induced by early movement restriction. EURON PhD Days, Feb 2024, Lille, France. 2024. hal-04477238

HAL Id: hal-04477238

https://hal.science/hal-04477238v1

Submitted on 26 Feb 2024

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# BENEFICIAL ROLE OF PHYSICAL ACTIVITY IN COUNTERACTING MUSCULOSKELETAL DISORDERS INDUCED BY EARLY MOVEMENT RESTRICTION

J. GIRARDIE, M. VAN GAEVER, O. DUPUIS, E. DUPONT, M.-H. CANU

Univ. Lille, Univ. Artois, Univ. Littoral Côte d'Opale

ULR 7369 - URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Loos, France

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Région
Hauts-de-France

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Unité de
Recherche
Pluridisciplinaire
Sport
Santé
Société

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## BACKGROUND

Insufficient physical activity, often associated to a sedentary lifestyle, is a health risk for many children and adolescents, especially those with chronic illnesses, accidents that require prolonged bed rest, or developmental coordination disorders (DCD). DCD can lead to motor skill difficulties, cognitive problems, and executive function disorders. Physical hypoactivity during childhood can lead to a variety of sensorimotor disorders including behavioral, metabolic, spinal and muscular alterations and can increase the risk of non-communicable diseases in the future.

Therefore, understanding use-dependent plasticity in children experiencing early hypoactivity is crucial. Otherwise, physical activity is widely recognized for its beneficial effects on general health, including muscles and brain and appears to be necessary for the harmonious maturation of the neuromuscular system.

**However, despite the importance of the topic, the ability of physical activity to counteract the deleterious effects of early sensorimotor restriction (SMR) remains to be demonstrated.**

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## METHODS

<figure><img src="image_6.png" /><figcaption>### GROUPS</figcaption></figure>

<figure><img src="image_7.png" /><figcaption>### IMMUNOHISTOCHEMISTRY</figcaption></figure>

<figure><img src="image_8.png" /><figcaption>### ANALYSIS</figcaption></figure>

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## RESULTS

### Soleus

<figure><img src="image_11.png" /><figcaption>Fiber area distribution of soleus (P60)</figcaption></figure>

**Persistant atrophy** is observed in **SMR SED** group, which is **partially prevented by activity**.

**No change in fiber type composition** is observed whatever the group.

### EDL

<figure><img src="image_12.png" /><figcaption>Fiber area distribution of EDL (P60)</figcaption></figure>

**No atrophy** is observed whatever the groups.

**A fast-to-slow transition** is observed in the SMR SED group.

<figure><img src="image_13.png" /></figure>

## CONCLUSION

To sum up, early SMR from birth to P28 has persistent detrimental effects that are not completely prevented by continued exercise from P28 to P60. Nevertheless, physical activity seems to be an interesting countermeasure to reverse some of the changes induced by early SMR.

However, **this type of physical activity** does not prevent all the alterations induced by the early sensorimotor restriction. Indeed, we used voluntary physical activity here. It could be interesting to evaluate the effect of a more controlled and standardized exercise protocol.