# SIRT1 wt Allele

National Cancer Institute

## Source

National Cancer Institute. SIRT 1 wt Allele. NCI Thesaurus. Code C80114.

Human SIRT 1 wild-type allele is located in the vicinity of 10q21.3 and is approximately 34 kb in length. This allele, which encodes NAD-dependent protein deacetylase sirtuin-1 protein, may play a role in the attenuation of protein acetylation. Genetic variation may be associated with the relapse of acute lymphoblastic leukemia.